Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| PTPDC1 | A2A3K4 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| MTMR11 | A4FU01 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PP2D1 | A8MPX8 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| EYA2 | O00167 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PPP6C | O00743 | AURKA, MAP3K7, MBP, H2AFX, PRKDC, | Non-protein substrates of this phosphatase are not reported yet |
| PTPRT | O14522 | CTNND1, CDH1, STAT3, PXN, | Non-protein substrates of this phosphatase are not reported yet |
| CTDSP2 | O14595 | POLR2A, SMAD3, SMAD2, SMAD1, | Non-protein substrates of this phosphatase are not reported yet |
| PPEF1 | O14829 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PPEF2 | O14830 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| GAK | O14976 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| CTDSPL | O15194 | RB1, SMAD3, CAMK2G, SMAD2, SMAD1, | Non-protein substrates of this phosphatase are not reported yet |
| PPM1G | O15355 | HIST1H2AG, H2AFX, COIL, SMN1, HIST1H2BM, DDX20, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP11 | O75319 | MBP, | Non-protein substrates of this phosphatase are not reported yet |
| PTP4A3 | O75365 | SLC9A3R1, ITGB1, KRT8, EZR, STMN1, NCL, BCAR1, | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate, |
| SBF1 | O95248 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| EPM2A | O95278 | GSK3B, NFU1, | amylopectin, glycogen, |
| CTDNEP1 | O95476 | BMPR1A, LPIN1, | Non-protein substrates of this phosphatase are not reported yet |
| EYA4 | O95677 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| ACPP | P15309 | ERBB2, | adenosine 5'-monophosphate, phosphatidic acid, 1-acyl-sn-glycerol 3-phosphate, glycerol 2-phosphate, thiamine(1+) monophosphate, |
| PTPRA | P18433 | FYN, LYN, SRC, PTPRA, BCAR1, EGFR, | Non-protein substrates of this phosphatase are not reported yet |
| PTPRD | P23468 | STAT3, | Non-protein substrates of this phosphatase are not reported yet |
| PTPRE | P23469 | INSR, FYN, YES1, SRC, MAPK3, MAPK1, KCNB1, | Non-protein substrates of this phosphatase are not reported yet |
| PTPRG | P23470 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PTPN3 | P26045 | GHR, CD247, MAPK12, VCP, EPS15, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN4 | P29074 | CD247, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN9 | P43378 | EGFR, ERBB2, NSF, | Non-protein substrates of this phosphatase are not reported yet |
| PPM1F | P49593 | PAK1, CAMK1, CAMK4, CAMK2A, | Non-protein substrates of this phosphatase are not reported yet |
| UBASH3A | P57075 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PTPN12 | Q05209 | PSTPIP1, ABL1, SRC, WAS, BCAR1, PTK2, PTK2B, EGFR, ERBB2, | Non-protein substrates of this phosphatase are not reported yet |
| CTDSPL2 | Q05D32 | POLR2A, | Non-protein substrates of this phosphatase are not reported yet |
| PUDP | Q08623 | Protein substrates of this phosphatase are not reported yet | pseudouridine 5'-phosphate, |
| PTP4A2 | Q12974 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PTPRS | Q13332 | EGFR, NTRK1, NTRK3, NTRK2, | Non-protein substrates of this phosphatase are not reported yet |
| PTPRK | Q15262 | EGFR, CTNNB1, AFDN, PARD3, PKP3, PKP4, CTNND1, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN14 | Q15678 | CTNNB1, | Non-protein substrates of this phosphatase are not reported yet |
| CDKN3 | Q16667 | CDK2, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN21 | Q16825 | SRC, | Non-protein substrates of this phosphatase are not reported yet |
| PTPRO | Q16827 | EPHB2, EPHA4, NTRK3, | Non-protein substrates of this phosphatase are not reported yet |
| PLPPR5 | Q32ZL2 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| TIMM50 | Q3ZCQ8 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| DUSP28 | Q4G0W2 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PTPN20 | Q4JDL3 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PPM1J | Q5JR12 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PPM1L | Q5SGD2 | MAP3K7, MAP3K5, COL4A3BP, | Non-protein substrates of this phosphatase are not reported yet |
| NT5DC1 | Q5TFE4 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| DUSP27 | Q5VZP5 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| TNS2 | Q63HR2 | Protein substrates of this phosphatase are not reported yet | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate, |
| TNS3 | Q68CZ2 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| DUPD1 | Q68J44 | MAPK3, MAPK1, MAPK14, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP13 | Q6B8I1 | MBP, | Non-protein substrates of this phosphatase are not reported yet |
| PLPPR3 | Q6T4P5 | Protein substrates of this phosphatase are not reported yet | phosphatidic acid, |
| TPTE2 | Q6XPS3 | Protein substrates of this phosphatase are not reported yet | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate, 1D-myo-inositol 1,3,4,5-tetrakisphosphate, 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate, |
| ACP7 | Q6ZNF0 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PLPPR4 | Q7Z2D5 | Protein substrates of this phosphatase are not reported yet | phosphatidic acid, 1-acyl-sn-glycerol 3-phosphate, |
| HDDC2 | Q7Z4H3 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| NT5DC3 | Q86UY8 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| MDP1 | Q86V88 | Protein substrates of this phosphatase are not reported yet | keto-D-fructose 6-phosphate, aldehydo-D-arabinose 5-phosphate, aldehydo-D-ribose 5-phosphate, D-ribofuranose 5-phosphate, fructoselysine 6-phosphate, D-fructofuranose 6-phosphate, |
| SBF2 | Q86WG5 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| RPAP2 | Q8IXW5 | POLR2A, | Non-protein substrates of this phosphatase are not reported yet |
| PLPP6 | Q8IY26 | Protein substrates of this phosphatase are not reported yet | presqualene diphosphate, phosphatidic acid, 2-trans,6-trans-farnesyl diphosphate, |
| PPM1K | Q8N3J5 | BCKDHA, | Non-protein substrates of this phosphatase are not reported yet |
| PPM1N | Q8N819 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PLPP7 | Q8NBV4 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| DUSP18 | Q8NEJ0 | MAPK8, | Non-protein substrates of this phosphatase are not reported yet |
| PPTC7 | Q8NI37 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PLPPR1 | Q8TBJ4 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PXYLP1 | Q8TE99 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| UBASH3B | Q8TF42 | EGFR, CBL, ZAP70, SYK, PTK2, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP19 | Q8WTR2 | MAPK9, | Non-protein substrates of this phosphatase are not reported yet |
| STYX | Q8WUJ0 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PTPMT1 | Q8WUK0 | Protein substrates of this phosphatase are not reported yet | 1-(3-sn-phosphatidyl)-sn-glycerol 3-phosphate, |
| UBLCP1 | Q8WVY7 | POLR2A, | Non-protein substrates of this phosphatase are not reported yet |
| PPM1E | Q8WY54 | PAK1, CAMK4, | Non-protein substrates of this phosphatase are not reported yet |
| PTPRU | Q92729 | EGFR, CTNNB1, | Non-protein substrates of this phosphatase are not reported yet |
| PTP4A1 | Q93096 | ATF7, | Non-protein substrates of this phosphatase are not reported yet |
| PLPPR2 | Q96GM1 | Protein substrates of this phosphatase are not reported yet | phosphatidic acid, |
| PPM1M | Q96MI6 | IKBKB, | Non-protein substrates of this phosphatase are not reported yet |
| MTMR9 | Q96QG7 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PNKP | Q96T60 | Protein substrates of this phosphatase are not reported yet | 3'-phosphopolynucleotide, |
| EYA3 | Q99504 | H2AFX, POLR2A, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN18 | Q99952 | PSTPIP1, ABL1, FYN, ARHGAP35, ERBB2, | Non-protein substrates of this phosphatase are not reported yet |
| CPPED1 | Q9BRF8 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| HDHD3 | Q9BSH5 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| DUSP26 | Q9BV47 | TP53, MAPK14, KIFAP3, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP23 | Q9BVJ7 | MBP, MAPK3, CTNNB1, | Non-protein substrates of this phosphatase are not reported yet |
| ACP4 | Q9BZG2 | ERBB4, | Non-protein substrates of this phosphatase are not reported yet |
| MTMR12 | Q9C0I1 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| CTDSP1 | Q9GZU7 | POLR2A, SMAD3, SMAD2, SMAD1, MYC, AKT1, REST, | Non-protein substrates of this phosphatase are not reported yet |
| ILKAP | Q9H0C8 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| HDHD2 | Q9H0R4 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| DUSP15 | Q9H1R2 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PTPN23 | Q9H3S7 | CDH1, SRC, CTNNB1, PTK2, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP21 | Q9H596 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| NT5DC2 | Q9H857 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| TNS1 | Q9HBL0 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PTPRH | Q9HD43 | LCK, SRC, BCAR1, DOK1, EGFR, | Non-protein substrates of this phosphatase are not reported yet |
| ACP6 | Q9NPH0 | Protein substrates of this phosphatase are not reported yet | 1-acyl-sn-glycerol 3-phosphate, |
| DUSP22 | Q9NRW4 | MBP, ESR1, MAPK1, STAT3, MAPK8, MAPK14, | Non-protein substrates of this phosphatase are not reported yet |
| PHPT1 | Q9NRX4 | KCNN4, HIST1H1C, ACLY, HIST1H4A, GNB1, | poly(lysine) polymer, |
| MTMR10 | Q9NXD2 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PDP1 | Q9P0J1 | PDHA1, PDHA2, SMAD1, | Non-protein substrates of this phosphatase are not reported yet |
| PDP2 | Q9P2J9 | PDHA1, PDHA2, SMAD1, | Non-protein substrates of this phosphatase are not reported yet |
| PALD1 | Q9ULE6 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PPM1H | Q9ULR3 | CDKN1B, CSE1L, | Non-protein substrates of this phosphatase are not reported yet |
| DUSP12 | Q9UNI6 | GCK, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN22 | Q9Y2R2 | LCK, CD247, ZAP70, SKAP2, | Non-protein substrates of this phosphatase are not reported yet |
| CTDP1 | Q9Y5B0 | POLR2A, MASTL, | Non-protein substrates of this phosphatase are not reported yet |
| STYXL1 | Q9Y6J8 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| DUSP14 | O95147 | MAPK3, MAPK9, MAPK14, | Non-protein substrates of this phosphatase are not reported yet |
| TPTE | P56180 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| Protein substrates in this pathway |
| Non-protein substrates in this pathway |
Non-protein substrates involved in this pathway are unknown (yet!)