Top MBP
Localization (UniProt annotation) Myelin membrane; Peripheral membraneprotein; Cytoplasmic side Note=Cytoplasmic side of myelin Isoform 3: Nucleus Note=Targeted to nucleus inoligodendrocytes Function (UniProt annotation) The classic group of MBP isoforms (isoform 4-isoform 14)are with PLP the most abundant protein components of the myelinmembrane in the CNS They have a role in both its formation andstabilization The smaller isoforms might have an important rolein remyelination of denuded axons in multiple sclerosis The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) maypreferentially have a role in the early developing brain longbefore myelination, maybe as components of transcriptionalcomplexes, and may also be involved in signaling pathways in T-cells and neural cells Differential splicing events combined withoptional post-translational modifications give a wide spectrum ofisomers, with each of them potentially having a specializedfunction Induces T-cell proliferation Catalytic Activity (UniProt annotation) N/A Protein Sequence MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQDTAVTDSKRTADPKNAWQDA
HPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTIQEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARH
GFLPRHRDTGILDSIGRFFGGDRGAPKRGSGKDSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKG
RGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR
ELM Motif Motif Instance Description Motif Regex NA NA NA NA
MBP is dephosphorylated by following phosphatases:
Phosphatase Gene Name Phosphatase UniProt_AC DephosphoSite and sequence (+/-5) in MBP (P02686) Bioassay Type PubMed ID View in Europe PMC Reliability of the interaction PPP1CA P62136 NA In vitro 8617739 , 16585947 , Europe PMC PPP1CB P62140 NA In vitro 8617739 , 16585947 , Europe PMC PPP1CC P36873 NA In vitro 8617739 , 16585947 , Europe PMC PPP2CA P67775 NA In vitro 9644267 , 10866685 , 16895907 , Europe PMC PPP2CB P62714 NA In vitro 9644267 , 10866685 , 16895907 , Europe PMC DUSP22 Q9NRW4 NA In vitro 12204117 , Europe PMC DUSP23 Q9BVJ7 NA In vitro 15281913 , Europe PMC DUSP11 O75319 NA In vitro 10347225 , Europe PMC PPP6C O00743 NA In vitro 16895907 , Europe PMC PTPN13 Q12923 NA In vitro 7929060 , Europe PMC DUSP13 Q9UII6 NA In vitro 10585869 , Europe PMC
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source APTX Two-hybrid, two hybrid physical, physical association 16713569 , (Europe PMC )0.37 BioGRID, IntAct ATN1 Two-hybrid, two hybrid physical, physical association 16713569 , (Europe PMC )0.37 BioGRID, IntAct ATXN1 Two-hybrid, two hybrid physical, physical association 16713569 , (Europe PMC )0.37 BioGRID, IntAct CDK1 Biochemical Activity physical 17906618 , (Europe PMC )NA BioGRID CDK5 Biochemical Activity physical 17906618 , (Europe PMC )NA BioGRID CDK7 Biochemical Activity physical 15328539 , (Europe PMC )NA BioGRID CDK8 Biochemical Activity physical 15328539 , (Europe PMC )NA BioGRID CDK9 Biochemical Activity physical 15328539 , 8170997 , (Europe PMC )NA BioGRID CTDSP1 Affinity Capture-MS, Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , 28514442 , (Europe PMC )0.49, 0.56 BioGRID, IntAct CTDSPL Affinity Capture-MS, two hybrid array, two hybrid prey pooling approach physical, physical association 28514442 , (Europe PMC )0.49 BioGRID, IntAct DDX58 Affinity Capture-Western physical 23264040 , (Europe PMC )NA BioGRID HIPK2 Biochemical Activity physical 11120354 , (Europe PMC )NA BioGRID HLA-DRA Co-crystal Structure physical 9782128 , (Europe PMC )NA BioGRID HNRNPL Affinity Capture-RNA physical 28611215 , (Europe PMC )NA BioGRID IDE Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID IKBKE Biochemical Activity physical 17599067 , (Europe PMC )NA BioGRID IRAK4 Biochemical Activity physical 15927069 , (Europe PMC )NA BioGRID LIMK1 Biochemical Activity physical 8537403 , (Europe PMC )NA BioGRID LIMK2 Biochemical Activity physical 8537403 , (Europe PMC )NA BioGRID LRRK2 Biochemical Activity physical 16269541 , 17260967 , 17584768 , 17706965 , 19826009 , 21806997 , (Europe PMC )NA BioGRID MAP3K1 Biochemical Activity physical 12624112 , (Europe PMC )NA BioGRID MAP3K3 Biochemical Activity physical 24975362 , (Europe PMC )NA BioGRID MAP3K5 Biochemical Activity physical 19293155 , (Europe PMC )NA BioGRID MAPK1 Affinity Capture-Western, Biochemical Activity, protein kinase assay phosphorylation reaction, physical 10371216 , 10464310 , 10958680 , 10978313 , 11258664 , 11570821 , 11983899 , 12588875 , 12944901 , 14530346 , 17255944 , 17906618 , 22778266 , 8846788 , 9596579 , (Europe PMC )0.44 BioGRID, IntAct, MINT MAPK11 Biochemical Activity physical 17906618 , (Europe PMC )NA BioGRID MAPK12 Biochemical Activity physical 17906618 , (Europe PMC )NA BioGRID MAPK13 Biochemical Activity physical 17906618 , (Europe PMC )NA BioGRID MAPK14 Biochemical Activity physical 10708586 , 10978313 , 12429732 , 17906618 , (Europe PMC )NA BioGRID MAPK3 Biochemical Activity physical 11570821 , 14530346 , 17906618 , 19910486 , (Europe PMC )NA BioGRID MAPK8 Biochemical Activity physical 10978313 , (Europe PMC )NA BioGRID MELK Biochemical Activity physical 16216881 , (Europe PMC )NA BioGRID MUS81 Synthetic Growth Defect genetic 24104479 , (Europe PMC )NA BioGRID MYH6 Affinity Capture-MS physical 26496610 , (Europe PMC )NA BioGRID NLN Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PKN1 Biochemical Activity physical 15791647 , (Europe PMC )NA BioGRID PLP1 Co-purification, Reconstituted Complex physical 2467009 , 6083474 , (Europe PMC )NA BioGRID PPP2R5C Biochemical Activity physical 15380617 , (Europe PMC )NA BioGRID PRKCA Biochemical Activity physical 15927069 , (Europe PMC )NA BioGRID PRKCB Biochemical Activity physical 24681954 , (Europe PMC )NA BioGRID PRKCD Biochemical Activity physical 12097319 , (Europe PMC )NA BioGRID PRKCI Biochemical Activity physical 21315177 , (Europe PMC )NA BioGRID PRKCZ Biochemical Activity physical 17639074 , 21315177 , (Europe PMC )NA BioGRID PRKDC Biochemical Activity physical 15147269 , (Europe PMC )NA BioGRID PRMT5 Biochemical Activity physical 11152681 , (Europe PMC )NA BioGRID PTPRA Biochemical Activity physical 23532252 , (Europe PMC )NA BioGRID RPS6KA5 Biochemical Activity physical 9873047 , (Europe PMC )NA BioGRID RPS6KA6 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SQSTM1 Reconstituted Complex physical 14702098 , (Europe PMC )NA BioGRID STK3 Biochemical Activity physical 20212043 , (Europe PMC )NA BioGRID STK39 Biochemical Activity physical 10980603 , (Europe PMC )NA BioGRID TBK1 Biochemical Activity physical 17599067 , (Europe PMC )NA BioGRID TLK1 Biochemical Activity physical 12955071 , (Europe PMC )NA BioGRID TRPM7 Biochemical Activity physical 14594813 , (Europe PMC )NA BioGRID TSSK6 Biochemical Activity physical 15870294 , (Europe PMC )NA BioGRID ULK1 Biochemical Activity physical 23524951 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source APTX Two-hybrid, two hybrid physical, physical association 16713569 , (Europe PMC )0.37 BioGRID, IntAct ATN1 Two-hybrid, two hybrid physical, physical association 16713569 , (Europe PMC )0.37 BioGRID, IntAct ATXN1 Two-hybrid, two hybrid physical, physical association 16713569 , (Europe PMC )0.37 BioGRID, IntAct CTDSP1 Affinity Capture-MS, Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , 28514442 , (Europe PMC )0.49, 0.56 BioGRID, IntAct CTDSPL Affinity Capture-MS, two hybrid array, two hybrid prey pooling approach physical, physical association 28514442 , (Europe PMC )0.49 BioGRID, IntAct HLA-DMA surface plasmon resonance association 21131964 , (Europe PMC )0.35 IntAct HLA-DRB1 fluorescence polarization spectroscopy association, physical association 21131964 , 23260142 , (Europe PMC )0.35, 0.40 IntAct MAPK1 Affinity Capture-Western, Biochemical Activity, protein kinase assay phosphorylation reaction, physical 10371216 , 10464310 , 10958680 , 10978313 , 11258664 , 11570821 , 11983899 , 12588875 , 12944901 , 14530346 , 17255944 , 17906618 , 22778266 , 8846788 , 9596579 , (Europe PMC )0.44 BioGRID, IntAct, MINT PBK protein kinase assay phosphorylation reaction 10779557 , (Europe PMC )0.44 IntAct, MINT PDGFRL two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT RXRB display technology physical association 20195357 , (Europe PMC )0.40 IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source APP anti bait coimmunoprecipitation association 16049941 , (Europe PMC )0.35 IntAct APTX Two-hybrid, two hybrid physical, physical association 16713569 , (Europe PMC )0.37 BioGRID, IntAct ATN1 Two-hybrid, two hybrid physical, physical association 16713569 , (Europe PMC )0.37 BioGRID, IntAct ATXN1 Two-hybrid, two hybrid physical, physical association 16713569 , (Europe PMC )0.37 BioGRID, IntAct CDK1 Biochemical Activity physical 17906618 , (Europe PMC )NA BioGRID CDK5 Biochemical Activity physical 17906618 , (Europe PMC )NA BioGRID CDK7 Biochemical Activity physical 15328539 , (Europe PMC )NA BioGRID CDK8 Biochemical Activity physical 15328539 , (Europe PMC )NA BioGRID CDK9 Biochemical Activity physical 15328539 , 8170997 , (Europe PMC )NA BioGRID CTDSP1 Affinity Capture-MS, Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , 28514442 , (Europe PMC )0.49, 0.56 BioGRID, IntAct CTDSPL Affinity Capture-MS, two hybrid array, two hybrid prey pooling approach physical, physical association 28514442 , (Europe PMC )0.49 BioGRID, IntAct DDX58 Affinity Capture-Western physical 23264040 , (Europe PMC )NA BioGRID HIPK2 Biochemical Activity physical 11120354 , (Europe PMC )NA BioGRID HLA-DMA surface plasmon resonance association 21131964 , (Europe PMC )0.35 IntAct HLA-DRA Co-crystal Structure physical 9782128 , (Europe PMC )NA BioGRID HLA-DRB1 fluorescence polarization spectroscopy association, physical association 21131964 , 23260142 , (Europe PMC )0.35, 0.40 IntAct HNRNPL Affinity Capture-RNA physical 28611215 , (Europe PMC )NA BioGRID IDE Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID IKBKE Biochemical Activity physical 17599067 , (Europe PMC )NA BioGRID IRAK4 Biochemical Activity physical 15927069 , (Europe PMC )NA BioGRID LIMK1 Biochemical Activity physical 8537403 , (Europe PMC )NA BioGRID LIMK2 Biochemical Activity physical 8537403 , (Europe PMC )NA BioGRID LRRK2 Biochemical Activity physical 16269541 , 17260967 , 17584768 , 17706965 , 19826009 , 21806997 , (Europe PMC )NA BioGRID MAP3K1 Biochemical Activity physical 12624112 , (Europe PMC )NA BioGRID MAP3K3 Biochemical Activity physical 24975362 , (Europe PMC )NA BioGRID MAP3K5 Biochemical Activity physical 19293155 , (Europe PMC )NA BioGRID MAPK1 Affinity Capture-Western, Biochemical Activity, protein kinase assay phosphorylation reaction, physical 10371216 , 10464310 , 10958680 , 10978313 , 11258664 , 11570821 , 11983899 , 12588875 , 12944901 , 14530346 , 17255944 , 17906618 , 22778266 , 8846788 , 9596579 , (Europe PMC )0.44 BioGRID, IntAct, MINT MAPK11 Biochemical Activity physical 17906618 , (Europe PMC )NA BioGRID MAPK12 Biochemical Activity physical 17906618 , (Europe PMC )NA BioGRID MAPK13 Biochemical Activity physical 17906618 , (Europe PMC )NA BioGRID MAPK14 Biochemical Activity physical 10708586 , 10978313 , 12429732 , 17906618 , (Europe PMC )NA BioGRID MAPK3 Biochemical Activity physical 11570821 , 14530346 , 17906618 , 19910486 , (Europe PMC )NA BioGRID MAPK8 Biochemical Activity physical 10978313 , (Europe PMC )NA BioGRID MELK Biochemical Activity physical 16216881 , (Europe PMC )NA BioGRID MUS81 Synthetic Growth Defect genetic 24104479 , (Europe PMC )NA BioGRID MYH6 Affinity Capture-MS physical 26496610 , (Europe PMC )NA BioGRID NLN Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PBK protein kinase assay phosphorylation reaction 10779557 , (Europe PMC )0.44 IntAct, MINT PDGFRL two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT PKN1 Biochemical Activity physical 15791647 , (Europe PMC )NA BioGRID PLP1 Co-purification, Reconstituted Complex physical 2467009 , 6083474 , (Europe PMC )NA BioGRID PPP2R5C Biochemical Activity physical 15380617 , (Europe PMC )NA BioGRID PRKCA Biochemical Activity physical 15927069 , (Europe PMC )NA BioGRID PRKCB Biochemical Activity physical 24681954 , (Europe PMC )NA BioGRID PRKCD Biochemical Activity physical 12097319 , (Europe PMC )NA BioGRID PRKCI Biochemical Activity physical 21315177 , (Europe PMC )NA BioGRID PRKCZ Biochemical Activity physical 17639074 , 21315177 , (Europe PMC )NA BioGRID PRKDC Biochemical Activity physical 15147269 , (Europe PMC )NA BioGRID PRMT5 Biochemical Activity physical 11152681 , (Europe PMC )NA BioGRID PTPRA Biochemical Activity physical 23532252 , (Europe PMC )NA BioGRID RPS6KA5 Biochemical Activity physical 9873047 , (Europe PMC )NA BioGRID RPS6KA6 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID RXRB display technology physical association 20195357 , (Europe PMC )0.40 IntAct SQSTM1 Reconstituted Complex physical 14702098 , (Europe PMC )NA BioGRID STK3 Biochemical Activity physical 20212043 , (Europe PMC )NA BioGRID STK39 Biochemical Activity physical 10980603 , (Europe PMC )NA BioGRID TBK1 Biochemical Activity physical 17599067 , (Europe PMC )NA BioGRID TLK1 Biochemical Activity physical 12955071 , (Europe PMC )NA BioGRID TRPM7 Biochemical Activity physical 14594813 , (Europe PMC )NA BioGRID TSSK6 Biochemical Activity physical 15870294 , (Europe PMC )NA BioGRID ULK1 Biochemical Activity physical 23524951 , (Europe PMC )NA BioGRID
Phosphorylating Kinases Phosphoresidues Detection Method PubMed IDs Source
Visualize a network of protein kinases and phosphatases phosphorylating and dephosphorylating this protein respectively
KIS S299_GRDSRSGsPMARR , LTP 10880969 ,(Europe PMC )PhosphoELM , MAPK1 T229_HFFKNIVtPRTPPPS , T232_KNIVTPRtPPPSQGK , T99_IRLFSRDtPGREDNT , LTP, in vitro 12760422 , 15380617 , 1939237 ,(Europe PMC )HPRD, PhosphoELM , PhosphoSitePlus , MAPK3 T232_KNIVTPRtPPPSQGK , LTP 1939237 ,(Europe PMC )PhosphoELM , PhosphoSitePlus , PRKACA S122_DELQTIQsDSAATSE , S133_ATSESLDsMASQKRP , S13_GKRELNAsKASTNSE , S141_MASQKRPsQRHGSKY , S146_RPSQRHGsKYLATAS , S148_SQRHGSKsLATASTM , S151_HGSKYLAsASTMDHA , S159_ASTMDHAsHGFLPRH , S162_MDHARHGsLPRHRDT , S177_GILDSIGsFFGGDRG , S188_GDRGAPKsGSGKDSH , S190_RGAPKRGsGKDSHHP , S266_FGYGGRAsDYKSAHK , S295_FKLGGRDsRSGSPMA , S57_DANQNNGsSSQDTAV , S8_MGNHAGKsELNAEKA , T169_FLPRHRDtGILDSIG , T36_KRNLGELtRTTSEDN , in vitro 2413024 ,(Europe PMC )HPRD, PRKCA S116_DRPSESDsLQTIQED , S122_DELQTIQsDSAATSE , S133_ATSESLDsMASQKRP , S13_GKRELNAsKASTNSE , S141_MASQKRPsQRHGSKY , S142_ASQKRPSsRHGSKYL , S146_RPSQRHGsKYLATAS , S148_SQRHGSKsLATASTM , S151_HGSKYLAsASTMDHA , S152_GSKYLATsSTMDHAR , S159_ASTMDHAsHGFLPRH , S162_MDHARHGsLPRHRDT , S167_HGFLPRHsDTGILDS , S177_GILDSIGsFFGGDRG , S178_ILDSIGRsFGGDRGA , S188_GDRGAPKsGSGKDSH , S190_RGAPKRGsGKDSHHP , S249_GLSLSRFsWGAEGQR , S266_FGYGGRAsDYKSAHK , S285_VDAQGTLsKIFKLGG , S295_FKLGGRDsRSGSPMA , S57_DANQNNGsSSQDTAV , S8_MGNHAGKsELNAEKA , in vitro 2413024 ,(Europe PMC )HPRD, Unknown S114_FKDRPSEsDELQTIQ , S205_ARTAHYGsLPQKSHG , S72_TDSKRTAsPKNAWQD , S96_PHLIRLFsRDAPGRE , S98_LIRLFSRsAPGREDN , T122_DELQTIQtDSAATSE , T229_HFFKNIVtPRTPPPS , T96_PHLIRLFtRDAPGRE , HTP, in vitro, in vivo 17081983 , 20058876 , 2449425 ,(Europe PMC )HPRD, PhosphoELM ,
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