Top PPP6C
Download FASTA sequences of PPP6C-substrates in Humans
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-204005 COPII-mediated vesicle transport. COPII components (known as Sec13p, Sec23p, Sec24p, Sec31p, and Sar1p in yeast) traffic cargo from the endoplasmic reticulum to the ER-Golgi intermediate compartment (ERGIC). COPII-coated vesicles were originally discovered in the yeast Saccharomyces cerevisiae using genetic approaches coupled with a cell-free assay. The mammalian counterpart of this pathway is represented here. Newly synthesized proteins destined for secretion are sorted into COPII-coated vesicles at specialized regions of the ER. These vesicles leave the ER, become uncoated and subsequently fuse with the ERGIC membrane
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ACLY Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID ANKRD28 Affinity Capture-MS, Proximity Label-MS, anti tag coimmunoprecipitation, molecular sieving, proximity-dependent biotin identification, pull down association, colocalization, physical, physical association 18186651 , 21187329 , 24255178 , 27880917 , 28330616 , (Europe PMC )0.79 BioGRID, IntAct, MINT ANKRD44 Affinity Capture-MS, anti tag coimmunoprecipitation, pull down association, physical 21187329 , 24255178 , 26186194 , 28330616 , 28514442 , (Europe PMC )0.64 BioGRID, IntAct, MINT ANKRD52 Affinity Capture-MS, anti tag coimmunoprecipitation, pull down association, physical 21187329 , 24255178 , 27880917 , 28330616 , (Europe PMC )0.64 BioGRID, IntAct, MINT ARAF Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 25852190 , (Europe PMC )0.35 BioGRID, IntAct ARHGEF2 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 24255178 , 27880917 , (Europe PMC )0.35 BioGRID, IntAct AURKA Affinity Capture-MS, genetic interference genetic interaction, physical 21187329 , 23443559 , (Europe PMC )0.17 BioGRID, IntAct, MINT AURKB Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID BRCA1 Affinity Capture-MS, Affinity Capture-Western physical 22990118 , 26831064 , (Europe PMC )NA BioGRID CEP19 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP44 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CSNK1D Affinity Capture-Western physical 23864707 , (Europe PMC )NA BioGRID EEF1AKMT3 Affinity Capture-MS physical 23349634 , (Europe PMC )NA BioGRID EGFR Affinity Capture-MS physical 23956138 , (Europe PMC )NA BioGRID ELAVL1 Affinity Capture-RNA physical 19322201 , (Europe PMC )NA BioGRID FBXO6 Affinity Capture-MS physical 22268729 , (Europe PMC )NA BioGRID IGBP1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, pull down, tandem affinity purification, two hybrid, two hybrid array, two hybrid prey pooling approach association, physical, physical association 16085932 , 18186651 , 24255178 , 26496610 , 27880917 , 28330616 , 9647778 , Europe PMC )0.93 BioGRID, IntAct ILK Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 25852190 , (Europe PMC )0.35 BioGRID, IntAct KRT8 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID MAP3K7 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, phosphatase assay dephosphorylation reaction, physical, physical association 17079228 , 19955178 , (Europe PMC )0.60 BioGRID, IntAct, MINT MAST3 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 25852190 , (Europe PMC )0.35 BioGRID, IntAct MOB1A Affinity Capture-Western, Proximity Label-MS, anti tag coimmunoprecipitation, proximity-dependent biotin identification association, colocalization, physical 24255178 , (Europe PMC )0.46 BioGRID, IntAct MOB1B Affinity Capture-Western, Proximity Label-MS, anti tag coimmunoprecipitation, confocal microscopy, proximity-dependent biotin identification association, colocalization, physical 24255178 , (Europe PMC )0.51 BioGRID, IntAct MYC Affinity Capture-MS, tandem affinity purification association, physical 17314511 , (Europe PMC )0.35 BioGRID, IntAct NOS2 Affinity Capture-MS physical 23438482 , (Europe PMC )NA BioGRID NTRK1 Affinity Capture-MS physical 25921289 , (Europe PMC )NA BioGRID PCGF1 Affinity Capture-MS physical 26687479 , (Europe PMC )NA BioGRID PIDD1 Affinity Capture-MS physical 21415862 , (Europe PMC )NA BioGRID POU5F1 Affinity Capture-MS physical 26687479 , (Europe PMC )NA BioGRID PPP6R1 Affinity Capture-MS, Proximity Label-MS, anti tag coimmunoprecipitation, chromatography technology, proximity-dependent biotin identification, pull down association, colocalization, physical, physical association 16769727 , 18186651 , 20065038 , 21187329 , 24255178 , 27880917 , 28330616 , (Europe PMC )0.86 BioGRID, IntAct, MINT PPP6R2 Affinity Capture-MS, Proximity Label-MS, anti tag coimmunoprecipitation, proximity-dependent biotin identification, pull down association, colocalization, physical, physical association 16769727 , 18186651 , 20065038 , 21187329 , 24255178 , 27880917 , 28330616 , 28514442 , (Europe PMC )0.83 BioGRID, IntAct, MINT PPP6R3 Affinity Capture-MS, Co-fractionation, Proximity Label-MS, anti tag coimmunoprecipitation, pull down association, physical, physical association 18186651 , 20065038 , 21187329 , 22939629 , 24255178 , 26344197 , 27880917 , 28330616 , (Europe PMC )0.74 BioGRID, IntAct, MINT PRKDC Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down association, physical 20065038 , 24255178 , 28330616 , (Europe PMC )0.53 BioGRID, IntAct RNF2 Affinity Capture-MS physical 24457600 , (Europe PMC )NA BioGRID SRRT Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID STK40 Affinity Capture-MS physical 28089446 , (Europe PMC )NA BioGRID TAB2 Affinity Capture-Western physical 19955178 , (Europe PMC )NA BioGRID TBK1 Affinity Capture-MS physical 14743216 , (Europe PMC )NA BioGRID TIPRL Affinity Capture-MS, Reconstituted Complex, anti tag coimmunoprecipitation association, direct interaction, physical, physical association 16085932 , 17384681 , 24255178 , 27880917 , (Europe PMC )0.70 BioGRID, IntAct, MINT TUBB6 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 24255178 , (Europe PMC )0.35 BioGRID, IntAct USP7 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID VCP Affinity Capture-MS physical 23383273 , (Europe PMC )NA BioGRID XPO1 Affinity Capture-MS physical 26673895 , (Europe PMC )NA BioGRID ZNRF2 Affinity Capture-Western, Biochemical Activity physical 27244671 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ANKRD44 Affinity Capture-MS, anti tag coimmunoprecipitation, pull down association, physical 21187329 , 24255178 , 26186194 , 28330616 , 28514442 , (Europe PMC )0.64 BioGRID, IntAct, MINT ANKRD52 Affinity Capture-MS, anti tag coimmunoprecipitation, pull down association, physical 21187329 , 24255178 , 27880917 , 28330616 , (Europe PMC )0.64 BioGRID, IntAct, MINT ARAF Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 25852190 , (Europe PMC )0.35 BioGRID, IntAct ARHGEF2 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 24255178 , 27880917 , (Europe PMC )0.35 BioGRID, IntAct AURKA Affinity Capture-MS, genetic interference genetic interaction, physical 21187329 , 23443559 , (Europe PMC )0.17 BioGRID, IntAct, MINT BCKDHA pull down association 28330616 , (Europe PMC )0.35 IntAct BCKDHB pull down association 28330616 , (Europe PMC )0.35 IntAct CCT2 pull down association 28330616 , (Europe PMC )0.35 IntAct CCT3 pull down association 28330616 , (Europe PMC )0.35 IntAct CCT4 pull down association 28330616 , (Europe PMC )0.35 IntAct CCT5 pull down association 28330616 , (Europe PMC )0.35 IntAct CCT6A pull down association 28330616 , (Europe PMC )0.35 IntAct CCT7 pull down association 28330616 , (Europe PMC )0.35 IntAct CEP19 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP44 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct DBT pull down association 28330616 , (Europe PMC )0.35 IntAct DLD pull down association 28330616 , (Europe PMC )0.35 IntAct ESR2 tandem affinity purification association 25604459 , (Europe PMC )0.35 IntAct HSPA8 pull down association 29568061 , (Europe PMC )0.35 IntAct IGBP1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, pull down, tandem affinity purification, two hybrid, two hybrid array, two hybrid prey pooling approach association, physical, physical association 16085932 , 18186651 , 24255178 , 26496610 , 27880917 , 28330616 , 9647778 , Europe PMC )0.93 BioGRID, IntAct ILK Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 25852190 , (Europe PMC )0.35 BioGRID, IntAct MAP3K7 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, phosphatase assay dephosphorylation reaction, physical, physical association 17079228 , 19955178 , (Europe PMC )0.60 BioGRID, IntAct, MINT MAST3 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 25852190 , (Europe PMC )0.35 BioGRID, IntAct MOB1A Affinity Capture-Western, Proximity Label-MS, anti tag coimmunoprecipitation, proximity-dependent biotin identification association, colocalization, physical 24255178 , (Europe PMC )0.46 BioGRID, IntAct MOB1B Affinity Capture-Western, Proximity Label-MS, anti tag coimmunoprecipitation, confocal microscopy, proximity-dependent biotin identification association, colocalization, physical 24255178 , (Europe PMC )0.51 BioGRID, IntAct MYC Affinity Capture-MS, tandem affinity purification association, physical 17314511 , (Europe PMC )0.35 BioGRID, IntAct NFKBIE tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct PPP4C anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct PPP6R1 Affinity Capture-MS, Proximity Label-MS, anti tag coimmunoprecipitation, chromatography technology, proximity-dependent biotin identification, pull down association, colocalization, physical, physical association 16769727 , 18186651 , 20065038 , 21187329 , 24255178 , 27880917 , 28330616 , (Europe PMC )0.86 BioGRID, IntAct, MINT PPP6R2 Affinity Capture-MS, Proximity Label-MS, anti tag coimmunoprecipitation, proximity-dependent biotin identification, pull down association, colocalization, physical, physical association 16769727 , 18186651 , 20065038 , 21187329 , 24255178 , 27880917 , 28330616 , 28514442 , (Europe PMC )0.83 BioGRID, IntAct, MINT PPP6R3 Affinity Capture-MS, Co-fractionation, Proximity Label-MS, anti tag coimmunoprecipitation, pull down association, physical, physical association 18186651 , 20065038 , 21187329 , 22939629 , 24255178 , 26344197 , 27880917 , 28330616 , (Europe PMC )0.74 BioGRID, IntAct, MINT PRKDC Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down association, physical 20065038 , 24255178 , 28330616 , (Europe PMC )0.53 BioGRID, IntAct RIPK4 anti tag coimmunoprecipitation association 26972000 , (Europe PMC )0.35 IntAct TCP1 pull down association 28330616 , (Europe PMC )0.35 IntAct TIPRL Affinity Capture-MS, Reconstituted Complex, anti tag coimmunoprecipitation association, direct interaction, physical, physical association 16085932 , 17384681 , 24255178 , 27880917 , (Europe PMC )0.70 BioGRID, IntAct, MINT TPM4 pull down association 28330616 , (Europe PMC )0.35 IntAct TUBB6 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 24255178 , (Europe PMC )0.35 BioGRID, IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ANKRD44 Affinity Capture-MS, anti tag coimmunoprecipitation, pull down association, physical 21187329 , 24255178 , 26186194 , 28330616 , 28514442 , (Europe PMC )0.64 BioGRID, IntAct, MINT ANKRD52 Affinity Capture-MS, anti tag coimmunoprecipitation, pull down association, physical 21187329 , 24255178 , 27880917 , 28330616 , (Europe PMC )0.64 BioGRID, IntAct, MINT AURKA Affinity Capture-MS, genetic interference genetic interaction, physical 21187329 , 23443559 , (Europe PMC )0.17 BioGRID, IntAct, MINT MAP3K7 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, phosphatase assay dephosphorylation reaction, physical, physical association 17079228 , 19955178 , (Europe PMC )0.60 BioGRID, IntAct, MINT PPP6R1 Affinity Capture-MS, Proximity Label-MS, anti tag coimmunoprecipitation, chromatography technology, proximity-dependent biotin identification, pull down association, colocalization, physical, physical association 16769727 , 18186651 , 20065038 , 21187329 , 24255178 , 27880917 , 28330616 , (Europe PMC )0.86 BioGRID, IntAct, MINT PPP6R2 Affinity Capture-MS, Proximity Label-MS, anti tag coimmunoprecipitation, proximity-dependent biotin identification, pull down association, colocalization, physical, physical association 16769727 , 18186651 , 20065038 , 21187329 , 24255178 , 27880917 , 28330616 , 28514442 , (Europe PMC )0.83 BioGRID, IntAct, MINT PPP6R3 Affinity Capture-MS, Co-fractionation, Proximity Label-MS, anti tag coimmunoprecipitation, pull down association, physical, physical association 18186651 , 20065038 , 21187329 , 22939629 , 24255178 , 26344197 , 27880917 , 28330616 , (Europe PMC )0.74 BioGRID, IntAct, MINT TIPRL Affinity Capture-MS, Reconstituted Complex, anti tag coimmunoprecipitation association, direct interaction, physical, physical association 16085932 , 17384681 , 24255178 , 27880917 , (Europe PMC )0.70 BioGRID, IntAct, MINT
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ACLY Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID ANKRD28 Affinity Capture-MS, Proximity Label-MS, anti tag coimmunoprecipitation, molecular sieving, proximity-dependent biotin identification, pull down association, colocalization, physical, physical association 18186651 , 21187329 , 24255178 , 27880917 , 28330616 , (Europe PMC )0.79 BioGRID, IntAct, MINT ANKRD44 Affinity Capture-MS, anti tag coimmunoprecipitation, pull down association, physical 21187329 , 24255178 , 26186194 , 28330616 , 28514442 , (Europe PMC )0.64 BioGRID, IntAct, MINT ANKRD52 Affinity Capture-MS, anti tag coimmunoprecipitation, pull down association, physical 21187329 , 24255178 , 27880917 , 28330616 , (Europe PMC )0.64 BioGRID, IntAct, MINT ARAF Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 25852190 , (Europe PMC )0.35 BioGRID, IntAct ARHGEF2 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 24255178 , 27880917 , (Europe PMC )0.35 BioGRID, IntAct AURKA Affinity Capture-MS, genetic interference genetic interaction, physical 21187329 , 23443559 , (Europe PMC )0.17 BioGRID, IntAct, MINT AURKB Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID BCKDHA pull down association 28330616 , (Europe PMC )0.35 IntAct BCKDHB pull down association 28330616 , (Europe PMC )0.35 IntAct BRCA1 Affinity Capture-MS, Affinity Capture-Western physical 22990118 , 26831064 , (Europe PMC )NA BioGRID CCT2 pull down association 28330616 , (Europe PMC )0.35 IntAct CCT3 pull down association 28330616 , (Europe PMC )0.35 IntAct CCT4 pull down association 28330616 , (Europe PMC )0.35 IntAct CCT5 pull down association 28330616 , (Europe PMC )0.35 IntAct CCT6A pull down association 28330616 , (Europe PMC )0.35 IntAct CCT7 pull down association 28330616 , (Europe PMC )0.35 IntAct CEP19 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP44 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CSNK1D Affinity Capture-Western physical 23864707 , (Europe PMC )NA BioGRID DBT pull down association 28330616 , (Europe PMC )0.35 IntAct DLD pull down association 28330616 , (Europe PMC )0.35 IntAct EEF1AKMT3 Affinity Capture-MS physical 23349634 , (Europe PMC )NA BioGRID EGFR Affinity Capture-MS physical 23956138 , (Europe PMC )NA BioGRID ELAVL1 Affinity Capture-RNA physical 19322201 , (Europe PMC )NA BioGRID ESR2 tandem affinity purification association 25604459 , (Europe PMC )0.35 IntAct FBXO6 Affinity Capture-MS physical 22268729 , (Europe PMC )NA BioGRID HSPA8 pull down association 29568061 , (Europe PMC )0.35 IntAct IGBP1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, pull down, tandem affinity purification, two hybrid, two hybrid array, two hybrid prey pooling approach association, physical, physical association 16085932 , 18186651 , 24255178 , 26496610 , 27880917 , 28330616 , 9647778 , Europe PMC )0.93 BioGRID, IntAct ILK Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 25852190 , (Europe PMC )0.35 BioGRID, IntAct KRT8 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID MAP3K7 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, phosphatase assay dephosphorylation reaction, physical, physical association 17079228 , 19955178 , (Europe PMC )0.60 BioGRID, IntAct, MINT MAST3 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 25852190 , (Europe PMC )0.35 BioGRID, IntAct MOB1A Affinity Capture-Western, Proximity Label-MS, anti tag coimmunoprecipitation, proximity-dependent biotin identification association, colocalization, physical 24255178 , (Europe PMC )0.46 BioGRID, IntAct MOB1B Affinity Capture-Western, Proximity Label-MS, anti tag coimmunoprecipitation, confocal microscopy, proximity-dependent biotin identification association, colocalization, physical 24255178 , (Europe PMC )0.51 BioGRID, IntAct MYC Affinity Capture-MS, tandem affinity purification association, physical 17314511 , (Europe PMC )0.35 BioGRID, IntAct NFKBIE tandem affinity purification physical association 14743216 , (Europe PMC )0.40 IntAct NOS2 Affinity Capture-MS physical 23438482 , (Europe PMC )NA BioGRID NTRK1 Affinity Capture-MS physical 25921289 , (Europe PMC )NA BioGRID PCGF1 Affinity Capture-MS physical 26687479 , (Europe PMC )NA BioGRID PIDD1 Affinity Capture-MS physical 21415862 , (Europe PMC )NA BioGRID POU5F1 Affinity Capture-MS physical 26687479 , (Europe PMC )NA BioGRID PPP4C anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct PPP6R1 Affinity Capture-MS, Proximity Label-MS, anti tag coimmunoprecipitation, chromatography technology, proximity-dependent biotin identification, pull down association, colocalization, physical, physical association 16769727 , 18186651 , 20065038 , 21187329 , 24255178 , 27880917 , 28330616 , (Europe PMC )0.86 BioGRID, IntAct, MINT PPP6R2 Affinity Capture-MS, Proximity Label-MS, anti tag coimmunoprecipitation, proximity-dependent biotin identification, pull down association, colocalization, physical, physical association 16769727 , 18186651 , 20065038 , 21187329 , 24255178 , 27880917 , 28330616 , 28514442 , (Europe PMC )0.83 BioGRID, IntAct, MINT PPP6R3 Affinity Capture-MS, Co-fractionation, Proximity Label-MS, anti tag coimmunoprecipitation, pull down association, physical, physical association 18186651 , 20065038 , 21187329 , 22939629 , 24255178 , 26344197 , 27880917 , 28330616 , (Europe PMC )0.74 BioGRID, IntAct, MINT PRKDC Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down association, physical 20065038 , 24255178 , 28330616 , (Europe PMC )0.53 BioGRID, IntAct RIPK4 anti tag coimmunoprecipitation association 26972000 , (Europe PMC )0.35 IntAct RNF2 Affinity Capture-MS physical 24457600 , (Europe PMC )NA BioGRID SRRT Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID STK40 Affinity Capture-MS physical 28089446 , (Europe PMC )NA BioGRID TAB2 Affinity Capture-Western physical 19955178 , (Europe PMC )NA BioGRID TBK1 Affinity Capture-MS physical 14743216 , (Europe PMC )NA BioGRID TCP1 pull down association 28330616 , (Europe PMC )0.35 IntAct TIPRL Affinity Capture-MS, Reconstituted Complex, anti tag coimmunoprecipitation association, direct interaction, physical, physical association 16085932 , 17384681 , 24255178 , 27880917 , (Europe PMC )0.70 BioGRID, IntAct, MINT TPM4 pull down association 28330616 , (Europe PMC )0.35 IntAct TUBB6 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 24255178 , (Europe PMC )0.35 BioGRID, IntAct USP7 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID VCP Affinity Capture-MS physical 23383273 , (Europe PMC )NA BioGRID XPO1 Affinity Capture-MS physical 26673895 , (Europe PMC )NA BioGRID ZNRF2 Affinity Capture-Western, Biochemical Activity physical 27244671 , (Europe PMC )NA BioGRID
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