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Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
PRKDC
Gene Name  | PRKDC (QuickGO) | (A quick tutorial to explore the interctive visulaization) Representative structure: 5LUQ |
| Synonyms | PRKDC, HYRC, HYRC1 | |
| Protein Name | PRKDC | |
| Alternative Name(s) | DNA-dependent protein kinase catalytic subunit;DNA-PK catalytic subunit;DNA-PKcs;2.7.11.1;DNPK1;p460; | |
| Protein Family | Belongs to the PI3/PI4-kinase family | |
| EntrezGene ID | 5591 (Comparitive Toxicogenomics) | |
| UniProt AC (Human) | P78527 (protein sequence) | |
| Enzyme Class | 2.7.11.1 (BRENDA ) | |
| Molecular Weight | 469089 Dalton | |
| Protein Length | 4128 amino acids (AA) | |
| Genome Browsers | NCBI | ENSG00000253729 (Ensembl) | UCSC | |
| Crosslinking annotations | Query our ID-mapping table | |
| Orthologues | Quest For Orthologues (QFO) | GeneTree | eggNOG - KOG0891 | eggNOG - COG5032 | |
| Phosphorylation Network | Visualize | |
| Domain organization, Expression, Diseases | (show / hide) |
| Protein Domain | InterPro | Pfam | SMART | 3D Structure | PDB | DrugPort | ModBase | SwissModel |
| Polypeptide organization (Pfam)  | |||
| Gene Expression | Gene Expression Atlas | Disease | OMIM | DisGeNet | ClinVar |
| Protein-protein interactions | STRING | IntAct | MINT | BioGRID | ||
| Phosphosites | Phospho.ELM | PhosphoSitePlus |
| Localization, Function, Catalytic activity and Sequence | (show / hide) |
| Localization (UniProt annotation) | |||
| Nucleus Nucleus, nucleolus | |||
| Function (UniProt annotation) | |||
| Serine/threonine-protein kinase that acts as a molecularsensor for DNA damage Involved in DNA non-homologous end joining(NHEJ) required for double-strand break (DSB) repair and V(D)Jrecombination Must be bound to DNA to express its catalyticproperties Promotes processing of hairpin DNA structures in V(D)Jrecombination by activation of the hairpin endonuclease artemis(DCLRE1C) The assembly of the DNA-PK complex at DNA ends is alsorequired for the NHEJ ligation step Required to protect and alignbroken ends of DNA May also act as a scaffold protein to aid thelocalization of DNA repair proteins to the site of damage Foundat the ends of chromosomes, suggesting a further role in themaintenance of telomeric stability and the prevention ofchromosomal end fusion Also involved in modulation oftranscription Recognizes the substrate consensus sequence [ST]-QPhosphorylates 'Ser-139' of histone variant H2AX/H2AFX, therebyregulating DNA damage response mechanism Phosphorylates DCLRE1C,c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1,DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2Can phosphorylate C1D not only in the presence of linear DNA butalso in the presence of supercoiled DNA Ability to phosphorylatep53/TP53 in the presence of supercoiled DNA is dependent on C1DContributes to the determination of the circadian period length byantagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1protein stability, most likely through an indirect mechanismInteracts with CRY1 and CRY2; negatively regulates CRY1phosphorylation Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNPcomplex, a complex that serves as a platform for IRF3phosphorylation and subsequent innate immune response activationthrough the cGAS-STING pathway | |||
| Catalytic Activity (UniProt annotation) | |||
| ATP + a protein = ADP + a phosphoprotein | |||
| Protein Sequence | |||
| MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRE CREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGEL ALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEE DPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFL KQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQT DTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCIS TVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILADEAFFSVNSSSESL NHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAE FFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYL KTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMM KSYVAWDREKRLSFAVPFREMKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQ LYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCGRCIREFLKWS IKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKS LGTIQQCCDAIDHLCRIIEKKHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLLLAALECYNTFIGERTVGALQ VLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGNRTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLK KDLCNTHLMRVLVQTLCEPASIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPD AQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCLPSLDLSCKQLASGLLELAFA FGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGM LDQSFRERANQKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLA DTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYVDCMKKFLDALELSQSPMLLE LMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLESVYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFF STIVVDAIDVLKSRFTKLNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCY DAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMER KKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDV LELEMDELNRHECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPY AKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKT LVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAA EVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEV VLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVEFVSHPSTTCREQMYNILMWI HDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATN FLLEMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQ QHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDFGKKRLGLPGDEVDNKVKGAA GRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQR DPIIAKQLFSSLFSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGC LASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFTSEIGTKQITQSALLAE ARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDCYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETY LPYMIRSKLKLLLQGEADQSLLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVL LHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPL PEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSY CRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRIL ELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQ AYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEE ITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNL KECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQ DQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYK DWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGI GDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTN TMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAV ARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM | |||
| Motif information from Eukaryotic Linear Motif atlas (ELM) | (show / hide) |
| ELM Motif | Motif Instance
| Description | Motif Regex |
| CLV_C14_Caspase3-7 | 2710-DEVDN-2714 | Caspase cleavage motif | [DSTE][^P][^DEWHFYC]D[GSAN] |
| Gene Ontology (P: Process; F: Function and C: Component terms) | (show / hide) | |
| GO:0000784 | C:nuclear chromosome |
| GO:0001756 | telomeric region |
| GO:0001933 | P:somitogenesis |
| GO:0002218 | P:negative regulation of protein phosphorylation |
| GO:0002326 | P:activation of innate immune response |
| GO:0002328 | P:B cell lineage commitment |
| GO:0002360 | P:pro-B cell differentiation |
| GO:0002638 | P:T cell lineage commitment |
| GO:0003690 | P:negative regulation of immunoglobulin production |
| GO:0003723 | F:double-stranded DNA binding |
| GO:0004672 | F:RNA binding |
| GO:0004674 | F:protein kinase activity |
| GO:0004677 | F:protein serine/threonine kinase activity |
| GO:0005524 | F:DNA-dependent protein kinase activity |
| GO:0005634 | F:ATP binding |
| GO:0005654 | C:nucleus |
| GO:0005667 | C:nucleoplasm |
| GO:0005730 | C:transcription factor complex |
| GO:0005829 | C:nucleolus |
| GO:0005958 | C:cytosol |
| GO:0006302 | C:DNA-dependent protein kinase-DNA ligase 4 complex |
| GO:0006303 | P:double-strand break repair |
| GO:0006464 | P:double-strand break repair via nonhomologous end joining |
| GO:0006468 | P:cellular protein modification process |
| GO:0007420 | P:protein phosphorylation |
| GO:0007507 | P:brain development |
| GO:0008134 | P:heart development |
| GO:0008283 | F:transcription factor binding |
| GO:0008630 | P:cell proliferation |
| GO:0010332 | P:intrinsic apoptotic signaling pathway in response to DNA damage |
| GO:0014823 | P:response to gamma radiation |
| GO:0016020 | P:response to activity |
| GO:0016233 | C:membrane |
| GO:0016567 | P:telomere capping |
| GO:0018105 | P:protein ubiquitination |
| GO:0019899 | P:peptidyl-serine phosphorylation |
| GO:0019904 | F:enzyme binding |
| GO:0031648 | F:protein domain specific binding |
| GO:0032481 | P:protein destabilization |
| GO:0032869 | P:positive regulation of type I interferon production |
| GO:0032991 | P:cellular response to insulin stimulus |
| GO:0032993 | C:protein-containing complex |
| GO:0033077 | C:protein-DNA complex |
| GO:0033152 | P:T cell differentiation in thymus |
| GO:0033153 | P:immunoglobulin V(D)J recombination |
| GO:0035234 | P:T cell receptor V(D)J recombination |
| GO:0042752 | P:ectopic germ cell programmed cell death |
| GO:0043065 | P:regulation of circadian rhythm |
| GO:0043066 | P:positive regulation of apoptotic process |
| GO:0045087 | P:negative regulation of apoptotic process |
| GO:0045944 | P:innate immune response |
| GO:0048146 | P:positive regulation of transcription by RNA polymerase II |
| GO:0048511 | P:positive regulation of fibroblast proliferation |
| GO:0048536 | P:rhythmic process |
| GO:0048538 | P:spleen development |
| GO:0048639 | P:thymus development |
| GO:0048660 | P:positive regulation of developmental growth |
| GO:0070419 | P:regulation of smooth muscle cell proliferation |
| GO:0072431 | C:nonhomologous end joining complex |
| GO:0097681 | P:signal transduction involved in mitotic G1 DNA damage checkpoint |
| GO:2000773 | P:double-strand break repair via alternative nonhomologous end joining |
| GO:2001229 | P:negative regulation of cellular senescence |
PRKDC is dephosphorylated by following phosphatases:
| Phosphatase Gene Name | Phosphatase UniProt_AC | DephosphoSite and sequence (+/-5) in PRKDC (P78527) | Bioassay Type | PubMed ID | View in Europe PMC | Reliability of the interaction |
| PPP6C | O00743 | NA | In vivo | 19198648, | Europe PMC |  |
| Pathway ID | Pathway Name | Pathway Description (KEGG) |
| hsa03450 | Non-homologous end-joining | Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone. |
| hsa04110 | Cell cycle | Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation. |
| Pathway ID | Pathway Name | Pathway Description (KEGG) |
| R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA. | Presence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon (IFN)-regulatory factors (DAI) (also called Z-DNA-binding protein 1, ZBP1), absent in melanoma 2 (AIM2), RNA polymerase III (Pol III), IFN-inducible protein IFI16, leucine-rich repeat flightless interacting protein-1 (LRRFIP1), DEAH-box helicases (DHX9 and DHX36), DEAD-box helicase DDX41, meiotic recombination 11 homolog A (MRE11), DNA-dependent protein kinase (DNA-PK), cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING). Detection of cytosolic DNA requires multiple and possibly redundant sensors leading to activation of the transcription factor NF-kappaB and TBK1-mediated phosphorylation of the transcription factor IRF3. Cytosolic DNA also activates caspase-1-dependent maturation of the pro-inflammatory cytokines interleukin IL-1beta and IL-18. This pathway is mediated by AIM2 |
| R-HSA-3270619 | IRF3-mediated induction of type I IFN. | TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3) are central regulators of type-I interferon induction during bacterial or viral infection. TBK1 was found to form complexes with distinct scaffolding proteins that appeared to target TBK1 to different subcellular compartments [Hemmi H et al 2004; Oganesyan G et al 2006; Chariot A et al 2002; Huang J et al 2005]. STING interacted with both TBK1 and IRF3. Once STING is stimulated, its C-terminus served as a signaling scaffold to recruit IRF3 anhd TBK1, which led to TBK1-dependent phosphorylation of IRF3. Phosphorylation of IRF3 promoted its dimerization and translocation to the nucleus, where it triggered the transcription of interferon stimulated genes (ISGs) (Tanaka Y and Chen ZJ 2012) |
| R-HSA-5693571 | Nonhomologous End-Joining (NHEJ). | The nonhomologous end joining (NHEJ) pathway is initiated in response to the formation of DNA double-strand breaks (DSBs) induced by DNA-damaging agents, such as ionizing radiation. DNA DSBs are recognized by the MRN complex (MRE11A:RAD50:NBN), leading to ATM activation and ATM-dependent recruitment of a number of DNA damage checkpoint and repair proteins to DNA DSB sites (Lee and Paull 2005). The ATM phosphorylated MRN complex, MDC1 and H2AFX-containing nucleosomes (gamma-H2AX) serve as scaffolds for the formation of nuclear foci known as ionizing radiation induced foci (IRIF) (Gatei et al. 2000, Paull et al. 2000, Stewart et al. 2003, Stucki et al. 2005). Ultimately, both BRCA1:BARD1 heterodimers and TP53BP1 (53BP1) are recruited to IRIF (Wang et al. 2007, Pei et al. 2011, Mallette et al. 2012), which is necessary for ATM-mediated CHEK2 activation (Wang et al. 2002, Wilson et al. 2008). In G1 cells, TP53BP1 promotes NHEJ by recruiting RIF1 and PAX1IP, which displaces BRCA1:BARD1 and associated proteins from the DNA DSB site and prevents resection of DNA DSBs needed for homologous recombination repair (HRR) (Escribano-Diaz et al. 2013, Zimmermann et al. 2013, Callen et al. 2013). TP53BP1 also plays an important role in ATM-mediated phosphorylation of DCLRE1C (ARTEMIS) (Riballo et al. 2004, Wang et al. 2014). Ku70:Ku80 heterodimer (also known as the Ku complex or XRCC5:XRCC6) binds DNA DSB ends, competing away the MRN complex and preventing MRN-mediated resection of DNA DSB ends (Walker et al. 2001, Sun et al. 2012). The catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs, PRKDC) is then recruited to DNA-bound Ku to form the DNA-PK holoenzyme. Two DNA-PK complexes, one at each side of the break, bring DNA DSB ends together, joining them in a synaptic complex (Gottlieb 1993, Yoo and Dynan 2000). DNA-PK complex recruits DCLRE1C (ARTEMIS) to DNA DSB ends (Ma et al. 2002). PRKDC-mediated phosphorylation of DCLRE1C, as well as PRKDC autophosphorylation, enables DCLRE1C to trim 3'- and 5'-overhangs at DNA DSBs, preparing them for ligation (Ma et al. 2002, Ma et al. 2005, Niewolik et al. 2006). The binding of inositol phosphate may additionally stimulate the catalytic activity of PRKDC (Hanakahi et al. 2000). Other factors, such as polynucleotide kinase (PNK), TDP1 or TDP2 may remove unligatable damaged nucleotides from 5'- and 3'-ends of the DSB, converting them to ligatable substrates (Inamdar et al. 2002, Gomez-Herreros et al. 2013). DNA ligase 4 (LIG4) in complex with XRCC4 (XRCC4:LIG4) is recruited to ligatable DNA DSB ends together with the XLF (NHEJ1) homodimer and DNA polymerases mu (POLM) and/or lambda (POLL) (McElhinny et al. 2000, Hsu et al. 2002, Malu et al. 2002, Ahnesorg et al. 2006, Mahajan et al. 2002, Lee et al. 2004, Fan and Wu 2004). After POLL and/or POLM fill 1- or 2-nucleotide long single strand gaps at aligned DNA DSB ends, XRCC4:LIG4 performs the ligation of broken DNA strands, thus completing NHEJ. The presence of NHEJ1 homodimer facilitates the ligation step, especially at mismatched DSB ends (Tsai et al. 2007). Depending on other types of DNA damage present at DNA DSBs, NHEJ can result in error-free products, produce dsDNA with microdeletions and/or mismatched bases, or result in translocations (reviewed by Povrik et al. 2012) |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins. | E3 ubiquitin ligases catalyze the transfer of an ubiquitin from an E2-ubiquitin conjugate to a target protein. Generally, ubiquitin is transferred via formation of an amide bond to a particular lysine residue of the target protein, but ubiquitylation of cysteine, serine and threonine residues in a few targeted proteins has also been demonstrated (reviewed in McDowell and Philpott 2013, Berndsen and Wolberger 2014). Based on protein homologies, families of E3 ubiquitin ligases have been identified that include RING-type ligases (reviewed in Deshaies et al. 2009, Metzger et al. 2012, Metzger et al. 2014), HECT-type ligases (reviewed in Rotin et al. 2009, Metzger et al. 2012), and RBR-type ligases (reviewed in Dove et al. 2016). A subset of the RING-type ligases participate in CULLIN-RING ligase complexes (CRLs which include SCF complexes, reviewed in Lee and Zhou 2007, Genschik et al. 2013, Skaar et al. 2013, Lee et al. 2014).Some E3-E2 combinations catalyze mono-ubiquitination of the target protein (reviewed in Nakagawa and Nakayama 2015). Other E3-E2 combinations catalyze conjugation of further ubiquitin monomers to the initial ubiquitin, forming polyubiquitin chains. (It may also be possible for some E3-E2 combinations to preassemble polyubiquitin and transfer it as a unit to the target protein.) Ubiquitin contains several lysine (K) residues and a free alpha amino group to which further ubiquitin can be conjugated. Thus different types of polyubiquitin are possible: K11 linked polyubiquitin is observed in endoplasmic reticulum-associated degradation (ERAD), K29 linked polyubiquitin is observed in lysosomal degradation, K48 linked polyubiquitin directs target proteins to the proteasome for degradation, whereas K63 linked polyubiquitin generally acts as a scaffold to recruit other proteins in several cellular processes, notably DNA repair (reviewed in Komander et al. 2009) |
| Interacting partner | Detection method | Interaction type | PubMed IDs | Interaction Score | Source |
| ADRB2 | Affinity Capture-MS | physical | 23798571, (Europe PMC) | NA | BioGRID |
| AHSA1 | Affinity Capture-Western | physical | 22504172, (Europe PMC) | NA | BioGRID |
| AICDA | Affinity Capture-Western, Reconstituted Complex | physical | 15634916, (Europe PMC) | NA | BioGRID |
| AIRE | Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation | association, physical, physical association | 20085707, (Europe PMC) | 0.50 | BioGRID, IntAct |
| AKT1 | Affinity Capture-Western, Biochemical Activity, Negative Genetic, Reconstituted Complex | genetic, physical | 15262962, 15678105, 28319113, (Europe PMC) | NA | BioGRID |
| AKT2 | Biochemical Activity | physical | 15678105, 16221682, (Europe PMC) | NA | BioGRID |
| AKTIP | Affinity Capture-Western | physical | 27535835, (Europe PMC) | NA | BioGRID |
| ALOX15 | Affinity Capture-Western | physical | 18785202, (Europe PMC) | NA | BioGRID |
| ANAPC2 | Affinity Capture-Western | physical | 26221070, (Europe PMC) | NA | BioGRID |
| AP1B1 | Protein-peptide | physical | 10608806, (Europe PMC) | NA | BioGRID |
| AP2M1 | Affinity Capture-MS | physical | 19380743, (Europe PMC) | NA | BioGRID |
| AR | Affinity Capture-MS, anti bait coimmunoprecipitation | association, physical, physical association | 15640154, 26175416, (Europe PMC) | 0.35, 0.50 | BioGRID, IntAct |
| ARHGEF6 | Affinity Capture-Western | physical | 19918261, (Europe PMC) | NA | BioGRID |
| ASB5 | Affinity Capture-MS | physical | 24337577, (Europe PMC) | NA | BioGRID |
| ATG101 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| ATG4C | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| ATM | Affinity Capture-Western, Protein-peptide | physical | 10464290, 10608806, (Europe PMC) | NA | BioGRID |
| ATOH1 | Affinity Capture-MS | physical | 27542412, (Europe PMC) | NA | BioGRID |
| ATRIP | Reconstituted Complex | physical | 15758953, (Europe PMC) | NA | BioGRID |
| ATRX | Affinity Capture-MS | physical | 23329831, (Europe PMC) | NA | BioGRID |
| AUP1 | Affinity Capture-MS | physical | 22119785, (Europe PMC) | NA | BioGRID |
| BAG3 | Affinity Capture-MS | physical | 23824909, (Europe PMC) | NA | BioGRID |
| BECN1 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| BIRC5 | Affinity Capture-Western | physical | 20394854, (Europe PMC) | NA | BioGRID |
| BMI1 | Affinity Capture-Western | physical | 20668194, (Europe PMC) | NA | BioGRID |
| BRCA1 | Protein-peptide | physical | 10608806, (Europe PMC) | NA | BioGRID |
| C1D | Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid | physical | 9679063, (Europe PMC) | NA | BioGRID |
| CAMKK2 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| CASP3 | Biochemical Activity | physical | 8804412, (Europe PMC) | NA | BioGRID |
| CCDC8 | Affinity Capture-MS | physical | 24711643, (Europe PMC) | NA | BioGRID |
| CCNB1 | Affinity Capture-Western, Reconstituted Complex | physical | 26221070, (Europe PMC) | NA | BioGRID |
| CDC5L | Affinity Capture-MS, Co-purification, anti bait coimmunoprecipitation | association, physical | 11101529, 20467437, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| CDC73 | Affinity Capture-MS | physical | 27462432, (Europe PMC) | NA | BioGRID |
| CDK2 | Affinity Capture-MS | physical | 21319273, (Europe PMC) | NA | BioGRID |
| CDK4 | Negative Genetic | genetic | 28319113, (Europe PMC) | NA | BioGRID |
| CDK9 | Negative Genetic | genetic | 28319113, (Europe PMC) | NA | BioGRID |
| CENPA | Affinity Capture-MS, tandem affinity purification | association, physical | 20080577, (Europe PMC) | 0.35 | BioGRID, IntAct |
| CFTR | Affinity Capture-MS, anti bait coimmunoprecipitation | association, physical | 17110338, 26618866, (Europe PMC) | 0.35 | BioGRID, IntAct |
| CHAF1A | Affinity Capture-MS | physical | 21209461, (Europe PMC) | NA | BioGRID |
| CHD1L | Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation | physical, physical association | 19661379, 19666485, (Europe PMC) | 0.40 | BioGRID, IntAct |
| CHEK1 | Negative Genetic, Protein-peptide, Reconstituted Complex | genetic, physical | 10608806, 12756247, 28319113, (Europe PMC) | NA | BioGRID |
| CHEK2 | Biochemical Activity | physical | 10713094, (Europe PMC) | NA | BioGRID |
| CHUK | Biochemical Activity, Reconstituted Complex | physical | 9632806, (Europe PMC) | NA | BioGRID |
| CIB1 | Affinity Capture-Western, Reconstituted Complex, Two-hybrid | physical | 15190070, 9372844, (Europe PMC) | NA | BioGRID |
| CLK1 | Biochemical Activity | physical | 26167880, (Europe PMC) | NA | BioGRID |
| CLN3 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, 23464991, (Europe PMC) | 0.40 | BioGRID, IntAct |
| COPS5 | Affinity Capture-MS | physical | 21145461, (Europe PMC) | NA | BioGRID |
| CRY1 | Affinity Capture-MS | physical | 25756610, (Europe PMC) | NA | BioGRID |
| CRY2 | Affinity Capture-MS | physical | 25756610, (Europe PMC) | NA | BioGRID |
| CSNK2A1 | Affinity Capture-Western, Co-localization | physical | 22404984, (Europe PMC) | NA | BioGRID |
| CTDP1 | Biochemical Activity, Protein-peptide | physical | 21450944, (Europe PMC) | NA | BioGRID |
| CTPS2 | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| CUL3 | Affinity Capture-MS | physical | 21145461, (Europe PMC) | NA | BioGRID |
| CUL5 | Affinity Capture-MS | physical | 21145461, (Europe PMC) | NA | BioGRID |
| CUL7 | Affinity Capture-MS | physical | 24711643, (Europe PMC) | NA | BioGRID |
| CWC27 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| CYLD | Affinity Capture-MS | physical | 27591049, (Europe PMC) | NA | BioGRID |
| DCAF1 | Biochemical Activity | physical | 22184063, (Europe PMC) | NA | BioGRID |
| DCLRE1B | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 26496610, (Europe PMC) | 0.35 | BioGRID, IntAct |
| DCLRE1C | Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation | association, physical, physical association | 11955432, 15456891, 15936993, 16857680, 22529269, (Europe PMC) | 0.61 | BioGRID, IntAct |
| DDA1 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| DDX5 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| DHX38 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| DHX9 | Affinity Capture-Western, Biochemical Activity, Co-fractionation | physical | 15613478, (Europe PMC) | NA | BioGRID |
| DNAJC7 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 26496610, (Europe PMC) | 0.35 | BioGRID, IntAct |
| E4F1 | Protein-peptide | physical | 10608806, (Europe PMC) | NA | BioGRID |
| EED | Affinity Capture-MS | physical | 24457600, (Europe PMC) | NA | BioGRID |
| EFTUD2 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| EGFR | Affinity Capture-MS, proximity ligation assay | physical, physical association | 23178489, 23956138, (Europe PMC) | 0.40 | BioGRID, IntAct |
| EHD1 | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| EIF2S2 | Co-purification | physical | 9442054, (Europe PMC) | NA | BioGRID |
| EIF4EBP1 | Biochemical Activity | physical | 10713094, (Europe PMC) | NA | BioGRID |
| ELAVL1 | Affinity Capture-RNA | physical | 19322201, (Europe PMC) | NA | BioGRID |
| ELP1 | Affinity Capture-MS | physical | 18303054, (Europe PMC) | NA | BioGRID |
| EMD | Affinity Capture-MS | physical | 23443559, (Europe PMC) | NA | BioGRID |
| EP300 | Reconstituted Complex, anti bait coimmunoprecipitation | association, physical | 20808282, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| EPHA1 | Affinity Capture-MS | physical | 28514442, (Europe PMC) | NA | BioGRID |
| ERG | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, chromatin immunoprecipitation assay, pull down | association, direct interaction, physical | 21575865, 24591637, (Europe PMC) | 0.35, 0.44, 0.46 | BioGRID, IntAct |
| ESR1 | Affinity Capture-MS, Affinity Capture-Western, affinity chromatography technology | association, physical | 16794079, 21182205, (Europe PMC) | 0.35 | BioGRID, IntAct |
| FAF2 | Affinity Capture-MS | physical | 22119785, (Europe PMC) | NA | BioGRID |
| FANCD2 | Synthetic Lethality | genetic | 24036544, (Europe PMC) | NA | BioGRID |
| FBXO6 | Affinity Capture-MS | physical | 22268729, (Europe PMC) | NA | BioGRID |
| FLII | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| FN1 | Affinity Capture-MS | physical | 19738201, (Europe PMC) | NA | BioGRID |
| FOXRED2 | Affinity Capture-MS | physical | 22119785, (Europe PMC) | NA | BioGRID |
| FZR1 | Affinity Capture-Western | physical | 26221070, (Europe PMC) | NA | BioGRID |
| GRK5 | Affinity Capture-MS | physical | 22952844, (Europe PMC) | NA | BioGRID |
| GSK3A | Biochemical Activity | physical | 15678105, (Europe PMC) | NA | BioGRID |
| GSK3B | Biochemical Activity | physical | 15678105, (Europe PMC) | NA | BioGRID |
| GTF2I | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| GZMB | Biochemical Activity | physical | 8760815, (Europe PMC) | NA | BioGRID |
| H2AFX | Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation | association, physical | 14627815, 15613478, 18406329, 20085707, 20356835, 22184063, (Europe PMC) | 0.35 | BioGRID, IntAct |
| H3F3A | Affinity Capture-MS | physical | 20504901, (Europe PMC) | NA | BioGRID |
| HDAC11 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 23752268, (Europe PMC) | 0.35 | BioGRID, IntAct |
| HDAC3 | Biochemical Activity | physical | 17242407, (Europe PMC) | NA | BioGRID |
| HDAC5 | Affinity Capture-MS | physical | 21081666, (Europe PMC) | NA | BioGRID |
| HDGF | Affinity Capture-MS, Affinity Capture-Western, pull down, tandem affinity purification | association, physical | 21907836, (Europe PMC) | 0.46 | BioGRID, IntAct |
| HDLBP | Affinity Capture-Western | physical | 15723802, (Europe PMC) | NA | BioGRID |
| HIST1H1A | Biochemical Activity | physical | 20356835, (Europe PMC) | NA | BioGRID |
| HIST1H1C | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex | physical | 18258596, (Europe PMC) | NA | BioGRID |
| HIST1H3A | Co-localization, proximity-dependent biotin identification, tandem affinity purification | association, physical | 20080577, 22404984, 29568061, (Europe PMC) | 0.53 | BioGRID, IntAct |
| HIST1H3E | Affinity Capture-MS, Co-purification | physical | 20080577, 20504901, 26527279, (Europe PMC) | NA | BioGRID |
| HNRNPA1 | Biochemical Activity | physical | 14704337, (Europe PMC) | NA | BioGRID |
| HNRNPC | Biochemical Activity | physical | 14704337, (Europe PMC) | NA | BioGRID |
| HOXB7 | Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down | association, physical, physical association | 17308091, (Europe PMC) | 0.50 | BioGRID, IntAct |
| HSF1 | Reconstituted Complex | physical | 9325337, (Europe PMC) | NA | BioGRID |
| HSP90AA1 | Affinity Capture-MS | physical | 16263121, (Europe PMC) | NA | BioGRID |
| HSP90AB1 | Affinity Capture-MS, anti bait coimmunoprecipitation | association, physical | 16263121, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| HSPA5 | Affinity Capture-MS | physical | 26496610, (Europe PMC) | NA | BioGRID |
| HSPA8 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| IGF1R | Negative Genetic | genetic | 28319113, (Europe PMC) | NA | BioGRID |
| IKBKB | Biochemical Activity | physical | 9632806, (Europe PMC) | NA | BioGRID |
| ILF2 | Affinity Capture-MS, Affinity Capture-Western, Co-purification, affinity chromatography technology | association, physical | 17389650, 20808282, 9442054, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| ILF3 | Affinity Capture-Western, Co-purification | physical | 21969602, 9442054, (Europe PMC) | NA | BioGRID |
| ILK | Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification | association, physical | 23455922, 25852190, (Europe PMC) | 0.53 | BioGRID, IntAct |
| IQCB1 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 21565611, (Europe PMC) | 0.35 | BioGRID, IntAct |
| ITGA4 | Affinity Capture-MS | physical | 22623428, (Europe PMC) | NA | BioGRID |
| JUN | Biochemical Activity, anti bait coimmunoprecipitation | association, physical | 25609649, 8464713, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| KAT2A | Biochemical Activity | physical | 9488450, (Europe PMC) | NA | BioGRID |
| KAT5 | Affinity Capture-Western | physical | 16603769, (Europe PMC) | NA | BioGRID |
| KAT8 | Affinity Capture-MS, Affinity Capture-Western | physical | 20479123, (Europe PMC) | NA | BioGRID |
| KEAP1 | Affinity Capture-MS | physical | 27621311, (Europe PMC) | NA | BioGRID |
| LGR4 | Affinity Capture-MS | physical | 24639526, (Europe PMC) | NA | BioGRID |
| LIG4 | Affinity Capture-Western, Biochemical Activity, Protein-peptide, anti bait coimmunoprecipitation | association, physical | 10608806, 15194694, 22529269, (Europe PMC) | 0.35 | BioGRID, IntAct |
| LMNA | Affinity Capture-Western, anti tag coimmunoprecipitation | association, physical | 21346760, (Europe PMC) | 0.35 | BioGRID, IntAct |
| LNX1 | Affinity Capture-MS | physical | 29121065, (Europe PMC) | NA | BioGRID |
| LPAR4 | Affinity Capture-MS | physical | 28514442, (Europe PMC) | NA | BioGRID |
| LRRFIP1 | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| LRRK2 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 17400507, 19826009, (Europe PMC) | 0.35 | BioGRID, IntAct |
| LYN | Reconstituted Complex | physical | 9748231, (Europe PMC) | NA | BioGRID |
| MAPK8 | Biochemical Activity | physical | 11749722, (Europe PMC) | NA | BioGRID |
| MAPK9 | Affinity Capture-Western, Biochemical Activity | physical | 11749722, 22366412, (Europe PMC) | NA | BioGRID |
| MBP | Biochemical Activity | physical | 15147269, (Europe PMC) | NA | BioGRID |
| MCM2 | Affinity Capture-MS | physical | 25963833, (Europe PMC) | NA | BioGRID |
| MDC1 | Affinity Capture-MS, Affinity Capture-Western, Co-localization, Reconstituted Complex | physical | 15377652, (Europe PMC) | NA | BioGRID |
| METTL1 | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| MEX3C | Affinity Capture-MS | physical | 26471122, (Europe PMC) | NA | BioGRID |
| MGMT | Affinity Capture-MS | physical | 16226712, (Europe PMC) | NA | BioGRID |
| MKNK1 | Two-hybrid, two hybrid pooling approach | physical, physical association | 20936779, (Europe PMC) | 0.37 | BioGRID, IntAct |
| MLH1 | Affinity Capture-MS | physical | 17148452, (Europe PMC) | NA | BioGRID |
| MRE11 | Protein-peptide | physical | 10608806, (Europe PMC) | NA | BioGRID |
| MSH6 | Affinity Capture-Western | physical | 21075794, (Europe PMC) | NA | BioGRID |
| MSL3 | Affinity Capture-Western | physical | 20479123, (Europe PMC) | NA | BioGRID |
| MTF1 | Affinity Capture-MS | physical | 28416769, (Europe PMC) | NA | BioGRID |
| MTNR1B | Two-hybrid, two hybrid | physical, physical association | 26514267, (Europe PMC) | 0.37 | BioGRID, IntAct |
| MTOR | Negative Genetic, anti bait coimmunoprecipitation | association, genetic | 24365180, 28319113, (Europe PMC) | 0.35 | BioGRID, IntAct |
| MYC | Affinity Capture-MS, Synthetic Lethality, tandem affinity purification | association, genetic, physical | 17314511, 25495526, (Europe PMC) | 0.35 | BioGRID, IntAct |
| NBN | Affinity Capture-MS, Reconstituted Complex | physical | 15758953, (Europe PMC) | NA | BioGRID |
| NCF1 | Biochemical Activity | physical | 9914162, (Europe PMC) | NA | BioGRID |
| NCF2 | Biochemical Activity | physical | 9914162, (Europe PMC) | NA | BioGRID |
| NCF4 | Biochemical Activity | physical | 9914162, (Europe PMC) | NA | BioGRID |
| NCOA6 | Affinity Capture-MS, Biochemical Activity | physical | 10823961, (Europe PMC) | NA | BioGRID |
| NFATC2 | Affinity Capture-MS | physical | 27637333, (Europe PMC) | NA | BioGRID |
| NIPSNAP2 | Affinity Capture-MS | physical | 20562859, (Europe PMC) | NA | BioGRID |
| NOS2 | Affinity Capture-MS | physical | 23438482, (Europe PMC) | NA | BioGRID |
| NOTCH1 | Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, tandem affinity purification | association, physical | 23022380, (Europe PMC) | 0.46 | BioGRID, IntAct, MINT |
| NR1H4 | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down | association, physical, physical association | 19833092, (Europe PMC) | 0.56 | BioGRID, IntAct |
| NR3C1 | Biochemical Activity | physical | 9038175, (Europe PMC) | NA | BioGRID |
| NTRK1 | Affinity Capture-MS | physical | 25921289, (Europe PMC) | NA | BioGRID |
| NUCB1 | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| NUP107 | Proximity Label-MS | physical | 24927568, (Europe PMC) | NA | BioGRID |
| NUP35 | Proximity Label-MS | physical | 24927568, (Europe PMC) | NA | BioGRID |
| NUP85 | Proximity Label-MS | physical | 24927568, (Europe PMC) | NA | BioGRID |
| OBSL1 | Affinity Capture-MS | physical | 24711643, (Europe PMC) | NA | BioGRID |
| PAN2 | Affinity Capture-MS | physical | 23398456, (Europe PMC) | NA | BioGRID |
| PARP1 | Affinity Capture-Western, anti bait coimmunoprecipitation | association, physical | 16794079, 20085707, 21575865, (Europe PMC) | 0.53 | BioGRID, IntAct |
| PCNA | Affinity Capture-MS | physical | 12171929, (Europe PMC) | NA | BioGRID |
| PDX1 | Biochemical Activity | physical | 16166097, (Europe PMC) | NA | BioGRID |
| PGR | Affinity Capture-Western, Biochemical Activity | physical | 10750018, (Europe PMC) | NA | BioGRID |
| PHGDH | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| PHKG2 | Affinity Capture-MS, tandem affinity purification | association, physical | 23455922, (Europe PMC) | 0.35 | BioGRID, IntAct |
| PIDD1 | Affinity Capture-MS | physical | 21415862, (Europe PMC) | NA | BioGRID |
| PINK1 | Affinity Capture-MS | physical | 21151955, (Europe PMC) | NA | BioGRID |
| PMS2 | Affinity Capture-MS | physical | 17148452, (Europe PMC) | NA | BioGRID |
| PNKP | Affinity Capture-MS | physical | 15385968, (Europe PMC) | NA | BioGRID |
| POT1 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 26496610, (Europe PMC) | 0.35 | BioGRID, IntAct |
| POU2F1 | Biochemical Activity | physical | 14612514, 17213819, (Europe PMC) | NA | BioGRID |
| POU5F1 | Affinity Capture-MS | physical | 26687479, (Europe PMC) | NA | BioGRID |
| PPP2CA | Affinity Capture-Western | physical | 20065038, (Europe PMC) | NA | BioGRID |
| PPP6C | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down | association, physical | 20065038, 24255178, 28330616, (Europe PMC) | 0.53 | BioGRID, IntAct |
| PPP6R1 | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex | physical | 20065038, (Europe PMC) | NA | BioGRID |
| PPP6R2 | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex | physical | 20065038, 28514442, (Europe PMC) | NA | BioGRID |
| PPP6R3 | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex | physical | 20065038, (Europe PMC) | NA | BioGRID |
| PRDX1 | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| PRKAB2 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| PRKDC | Biochemical Activity | physical | 10750018, 20065038, (Europe PMC) | NA | BioGRID |
| PRPF8 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| PTER | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| RAD17 | Protein-peptide | physical | 10608806, (Europe PMC) | NA | BioGRID |
| RAD21 | Affinity Capture-Western, Co-fractionation | physical | 22145905, 22939629, (Europe PMC) | NA | BioGRID |
| RANBP2 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| RASSF1 | Protein-peptide | physical | 10608806, (Europe PMC) | NA | BioGRID |
| RBBP8 | Protein-peptide | physical | 10608806, (Europe PMC) | NA | BioGRID |
| RBM25 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| RECQL5 | Affinity Capture-MS | physical | 19270065, (Europe PMC) | NA | BioGRID |
| RELA | Affinity Capture-MS, tandem affinity purification | physical, physical association | 14743216, 25331947, (Europe PMC) | 0.40 | BioGRID, IntAct |
| RFC2 | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| RNF144A | Affinity Capture-Western, Biochemical Activity, Reconstituted Complex | physical | 24979766, (Europe PMC) | NA | BioGRID |
| RPA1 | Affinity Capture-MS, Reconstituted Complex | physical | 10064605, 21504906, 24332808, (Europe PMC) | NA | BioGRID |
| RPA2 | Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex | physical | 10064605, 10713094, 16540648, 24332808, 8943020, 9295339, (Europe PMC) | NA | BioGRID |
| RPA3 | Affinity Capture-MS | physical | 24332808, (Europe PMC) | NA | BioGRID |
| RPS11 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| RRM2 | Negative Genetic | genetic | 28319113, (Europe PMC) | NA | BioGRID |
| RTCB | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| RTRAF | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| RUVBL1 | Affinity Capture-MS, pull down | association, physical | 20371770, (Europe PMC) | 0.35 | BioGRID, IntAct |
| RYK | Affinity Capture-MS | physical | 21875946, (Europe PMC) | NA | BioGRID |
| SAP25 | Affinity Capture-MS | physical | 16449650, (Europe PMC) | NA | BioGRID |
| SCARNA22 | Affinity Capture-RNA | physical | 22751105, (Europe PMC) | NA | BioGRID |
| SF3B6 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| SHC1 | Affinity Capture-MS | physical | 19380743, (Europe PMC) | NA | BioGRID |
| SIRT6 | Affinity Capture-MS, Affinity Capture-Western, Co-localization | physical | 20157594, 24169447, (Europe PMC) | NA | BioGRID |
| SIRT7 | Affinity Capture-MS | physical | 22586326, (Europe PMC) | NA | BioGRID |
| SKI | Affinity Capture-MS | physical | 25670202, (Europe PMC) | NA | BioGRID |
| SMARCA5 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| SMARCAD1 | Affinity Capture-MS | physical | 21549307, (Europe PMC) | NA | BioGRID |
| SNRPA | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| SNW1 | Affinity Capture-MS, anti bait coimmunoprecipitation | association, physical | 20467437, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| SP1 | Biochemical Activity | physical | 8422676, (Europe PMC) | NA | BioGRID |
| SRF | Biochemical Activity | physical | 8407951, (Europe PMC) | NA | BioGRID |
| SRP14 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| SRP54 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| SRSF10 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| STAU1 | Affinity Capture-MS | physical | 23125841, (Europe PMC) | NA | BioGRID |
| SUMO2 | Reconstituted Complex | physical | 19394292, (Europe PMC) | NA | BioGRID |
| TELO2 | Affinity Capture-MS, Affinity Capture-Western, affinity chromatography technology, anti bait coimmunoprecipitation, tandem affinity purification | association, physical | 18160036, 20427287, 20801936, (Europe PMC) | 0.60 | BioGRID, IntAct |
| TERF1 | Affinity Capture-Western | physical | 18160036, (Europe PMC) | NA | BioGRID |
| TES | Affinity Capture-MS | physical | 28378594, (Europe PMC) | NA | BioGRID |
| THOC6 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| THRA | Affinity Capture-MS, Reconstituted Complex | physical | 17242407, (Europe PMC) | NA | BioGRID |
| THRB | Affinity Capture-MS, Reconstituted Complex | physical | 17242407, (Europe PMC) | NA | BioGRID |
| THYN1 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| TINF2 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 26496610, (Europe PMC) | 0.35 | BioGRID, IntAct |
| TP53 | Affinity Capture-Western, Biochemical Activity, Protein-peptide | physical | 10608806, 10713094, 12756247, 19918261, 25362358, 9363941, 9679063, 9744860, (Europe PMC) | NA | BioGRID |
| TPR | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| TRA2B | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| TRIM25 | Affinity Capture-MS | physical | 29117863, (Europe PMC) | NA | BioGRID |
| TTI1 | Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, pull down | association, physical | 20371770, 20427287, 20810650, (Europe PMC) | 0.53 | BioGRID, IntAct |
| TTI2 | Affinity Capture-MS, tandem affinity purification | association, physical | 20801936, (Europe PMC) | 0.35 | BioGRID, IntAct |
| U2AF2 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| UBAC2 | Affinity Capture-MS | physical | 22119785, (Europe PMC) | NA | BioGRID |
| UBE2I | Biochemical Activity | physical | 19596686, (Europe PMC) | NA | BioGRID |
| UBXN6 | Affinity Capture-MS | physical | 22337587, (Europe PMC) | NA | BioGRID |
| USF1 | Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay | association, phosphorylation reaction, physical, physical association | 19303849, (Europe PMC) | 0.62 | BioGRID, IntAct |
| VCAM1 | Affinity Capture-MS, cross-linking study | association, physical | 19738201, 22623428, (Europe PMC) | 0.35 | BioGRID, IntAct |
| VHL | Negative Genetic | genetic | 28319113, (Europe PMC) | NA | BioGRID |
| WRN | Affinity Capture-Western, Biochemical Activity, Protein-peptide | physical | 10608806, 11889123, (Europe PMC) | NA | BioGRID |
| XPA | Biochemical Activity, anti tag coimmunoprecipitation | association, physical | 16540648, 20304803, (Europe PMC) | 0.35 | BioGRID, IntAct |
| XRCC1 | Affinity Capture-Western | physical | 18678286, (Europe PMC) | NA | BioGRID |
| XRCC4 | Affinity Capture-Western, Co-fractionation | physical | 15194694, 15520013, 22939629, (Europe PMC) | NA | BioGRID |
| XRCC5 | Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-fractionation, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay, proximity ligation assay, x-ray crystallography | association, direct interaction, phosphorylation reaction, physical, physical association | 10446239, 10750018, 12393188, 15520013, 15758953, 16857680, 17308091, 19303849, 20023628, 20085707, 20711232, 21679440, 22404984, 26344197, 26496610, 9312071, (Europe PMC) | 0.88 | BioGRID, IntAct |
| XRCC6 | Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-fractionation, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay, proximity ligation assay | association, phosphorylation reaction, physical, physical association | 10064605, 10750018, 15520013, 17308091, 19303849, 20711232, 21575865, 21969602, 22939629, 26175416, 26496610, 8422676, (Europe PMC) | 0.87 | BioGRID, IntAct |
| YBX1 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| YWHAQ | Affinity Capture-MS, Reconstituted Complex | physical | 15161933, 20618440, (Europe PMC) | NA | BioGRID |
| YY1 | Co-purification, cosedimentation through density gradient, pull down | association, physical, physical association | 18026119, (Europe PMC) | 0.50 | BioGRID, IntAct |
| ZNF746 | Affinity Capture-MS | physical | 25315684, (Europe PMC) | NA | BioGRID |
| Interacting partner | Detection method | Interaction type | PubMed IDs | Interaction Score | Source |
| APEX1 | affinity chromatography technology | association | 20808282, (Europe PMC) | 0.35 | IntAct, MINT |
| APLF | pull down | association | 17396150, (Europe PMC) | 0.35 | IntAct, MINT |
| AR | Affinity Capture-MS, anti bait coimmunoprecipitation | association, physical, physical association | 15640154, 26175416, (Europe PMC) | 0.35, 0.50 | BioGRID, IntAct |
| ATG101 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| ATG4C | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| BECN1 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| CAMKK2 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| CBFA2T2 | anti tag coimmunoprecipitation | association | 27281218, (Europe PMC) | 0.35 | IntAct |
| CBX3 | tandem affinity purification | association | 21888893, (Europe PMC) | 0.35 | IntAct |
| CCNC | chromatography technology | physical association | 19047373, (Europe PMC) | 0.40 | IntAct |
| CD81 | anti bait coimmunoprecipitation | association | 26212323, (Europe PMC) | 0.35 | IntAct |
| CDC5L | Affinity Capture-MS, Co-purification, anti bait coimmunoprecipitation | association, physical | 11101529, 20467437, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| CDK8 | anti bait coimmunoprecipitation | physical association | 19047373, (Europe PMC) | 0.40 | IntAct |
| CENPA | Affinity Capture-MS, tandem affinity purification | association, physical | 20080577, (Europe PMC) | 0.35 | BioGRID, IntAct |
| CFTR | Affinity Capture-MS, anti bait coimmunoprecipitation | association, physical | 17110338, 26618866, (Europe PMC) | 0.35 | BioGRID, IntAct |
| CHD1L | Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation | physical, physical association | 19661379, 19666485, (Europe PMC) | 0.40 | BioGRID, IntAct |
| CLN3 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, 23464991, (Europe PMC) | 0.40 | BioGRID, IntAct |
| CSNK2A2 | proximity ligation assay | physical association | 20711232, (Europe PMC) | 0.40 | IntAct |
| DCLRE1B | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 26496610, (Europe PMC) | 0.35 | BioGRID, IntAct |
| DCLRE1C | Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation | association, physical, physical association | 11955432, 15456891, 15936993, 16857680, 22529269, (Europe PMC) | 0.61 | BioGRID, IntAct |
| DDA1 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| DEAF1 | pull down | physical association | 22442688, (Europe PMC) | 0.40 | IntAct |
| DNAJC7 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 26496610, (Europe PMC) | 0.35 | BioGRID, IntAct |
| DTNBP1 | pull down | association | 19142223, (Europe PMC) | 0.35 | IntAct |
| DUX4 | pull down | association | 26816005, (Europe PMC) | 0.35 | IntAct |
| E2F3 | pull down | association | 22157815, (Europe PMC) | 0.35 | IntAct, MINT |
| EGFR | Affinity Capture-MS, proximity ligation assay | physical, physical association | 23178489, 23956138, (Europe PMC) | 0.40 | BioGRID, IntAct |
| ENSG00000096060 | chromatin immunoprecipitation assay | association | 21575865, (Europe PMC) | 0.35 | IntAct |
| ENSG00000124126 | chromatin immunoprecipitation assay | association | 26175416, (Europe PMC) | 0.35 | IntAct |
| ENSG00000132470 | chromatin immunoprecipitation assay | association | 26175416, (Europe PMC) | 0.35 | IntAct |
| ENSG00000134318 | chromatin immunoprecipitation assay | association | 26175416, (Europe PMC) | 0.35 | IntAct |
| ENSG00000142515 | chromatin immunoprecipitation assay | association | 21575865, 26175416, (Europe PMC) | 0.53 | IntAct |
| ENSG00000144837 | chromatin immunoprecipitation assay | association | 21575865, 26175416, (Europe PMC) | 0.53 | IntAct |
| ENSG00000160182 | chromatin immunoprecipitation assay | association | 25303530, (Europe PMC) | 0.35 | IntAct |
| ENSG00000169710 | chromatin immunoprecipitation assay | association | 19303849, (Europe PMC) | 0.35 | IntAct |
| ENSG00000184012 | chromatin immunoprecipitation assay | association | 21575865, 26175416, (Europe PMC) | 0.53 | IntAct |
| ENSG00000196208 | chromatin immunoprecipitation assay | association | 25303530, (Europe PMC) | 0.35 | IntAct |
| ENSG00000196620 | chromatin immunoprecipitation assay | association | 26175416, (Europe PMC) | 0.35 | IntAct |
| ENSG00000197888 | chromatin immunoprecipitation assay | association | 26175416, (Europe PMC) | 0.35 | IntAct |
| EP300 | Reconstituted Complex, anti bait coimmunoprecipitation | association, physical | 20808282, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| ERG | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, chromatin immunoprecipitation assay, pull down | association, direct interaction, physical | 21575865, 24591637, (Europe PMC) | 0.35, 0.44, 0.46 | BioGRID, IntAct |
| ESR1 | Affinity Capture-MS, Affinity Capture-Western, affinity chromatography technology | association, physical | 16794079, 21182205, (Europe PMC) | 0.35 | BioGRID, IntAct |
| ESR2 | affinity chromatography technology | association | 21182203, (Europe PMC) | 0.35 | IntAct |
| ETS1 | anti tag coimmunoprecipitation, pull down | association, direct interaction | 21575865, (Europe PMC) | 0.52 | IntAct |
| ETV1 | anti tag coimmunoprecipitation, pull down | association, direct interaction | 21575865, (Europe PMC) | 0.52 | IntAct |
| GABARAP | anti tag coimmunoprecipitation | association | 20562859, (Europe PMC) | 0.35 | IntAct |
| GABARAPL1 | anti tag coimmunoprecipitation | association | 20562859, (Europe PMC) | 0.35 | IntAct |
| GABARAPL2 | anti tag coimmunoprecipitation | association | 20562859, (Europe PMC) | 0.35 | IntAct |
| GOLPH3 | protein kinase assay | phosphorylation reaction | 24485452, (Europe PMC) | 0.44 | IntAct |
| GRB2 | pull down | association | 12577067, (Europe PMC) | 0.35 | IntAct |
| H2AFX | Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation | association, physical | 14627815, 15613478, 18406329, 20085707, 20356835, 22184063, (Europe PMC) | 0.35 | BioGRID, IntAct |
| HDAC11 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 23752268, (Europe PMC) | 0.35 | BioGRID, IntAct |
| HDGF | Affinity Capture-MS, Affinity Capture-Western, pull down, tandem affinity purification | association, physical | 21907836, (Europe PMC) | 0.46 | BioGRID, IntAct |
| HIST1H3A | Co-localization, proximity-dependent biotin identification, tandem affinity purification | association, physical | 20080577, 22404984, 29568061, (Europe PMC) | 0.53 | BioGRID, IntAct |
| HOXB7 | Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down | association, physical, physical association | 17308091, (Europe PMC) | 0.50 | BioGRID, IntAct |
| HSP90AB1 | Affinity Capture-MS, anti bait coimmunoprecipitation | association, physical | 16263121, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| HSPA5 | anti tag coimmunoprecipitation | association | 26496610, (Europe PMC) | 0.35 | IntAct |
| IGFBP3 | anti bait coimmunoprecipitation, proximity ligation assay | association, physical association | 23178489, (Europe PMC) | 0.50 | IntAct |
| IKBKG | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| ILF2 | Affinity Capture-MS, Affinity Capture-Western, Co-purification, affinity chromatography technology | association, physical | 17389650, 20808282, 9442054, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| ILK | Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification | association, physical | 23455922, 25852190, (Europe PMC) | 0.53 | BioGRID, IntAct |
| IQCB1 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 21565611, (Europe PMC) | 0.35 | BioGRID, IntAct |
| ISG15 | pull down | association | 26259872, (Europe PMC) | 0.35 | IntAct |
| JUN | Biochemical Activity, anti bait coimmunoprecipitation | association, physical | 25609649, 8464713, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| LIG4 | Affinity Capture-Western, Biochemical Activity, Protein-peptide, anti bait coimmunoprecipitation | association, physical | 10608806, 15194694, 22529269, (Europe PMC) | 0.35 | BioGRID, IntAct |
| LMNA | Affinity Capture-Western, anti tag coimmunoprecipitation | association, physical | 21346760, (Europe PMC) | 0.35 | BioGRID, IntAct |
| LRRK2 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 17400507, 19826009, (Europe PMC) | 0.35 | BioGRID, IntAct |
| MAP1LC3A | anti tag coimmunoprecipitation | association | 20562859, (Europe PMC) | 0.35 | IntAct |
| MAP1LC3B | anti tag coimmunoprecipitation | association | 20562859, (Europe PMC) | 0.35 | IntAct |
| MAP3K3 | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| MAPKAP1 | anti bait coimmunoprecipitation | association, physical association | 24365180, (Europe PMC) | 0.50 | IntAct |
| MED13 | anti bait coimmunoprecipitation | physical association | 19047373, (Europe PMC) | 0.40 | IntAct |
| MKNK1 | Two-hybrid, two hybrid pooling approach | physical, physical association | 20936779, (Europe PMC) | 0.37 | BioGRID, IntAct |
| MTNR1B | Two-hybrid, two hybrid | physical, physical association | 26514267, (Europe PMC) | 0.37 | BioGRID, IntAct |
| MTOR | Negative Genetic, anti bait coimmunoprecipitation | association, genetic | 24365180, 28319113, (Europe PMC) | 0.35 | BioGRID, IntAct |
| MYC | Affinity Capture-MS, Synthetic Lethality, tandem affinity purification | association, genetic, physical | 17314511, 25495526, (Europe PMC) | 0.35 | BioGRID, IntAct |
| NFKB1 | tandem affinity purification | association | 25609649, (Europe PMC) | 0.35 | IntAct, MINT |
| NFKB2 | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| NFKBIE | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| NIPSNAP2 | anti tag coimmunoprecipitation | physical association | 20562859, (Europe PMC) | 0.40 | IntAct |
| NOTCH1 | Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, tandem affinity purification | association, physical | 23022380, (Europe PMC) | 0.46 | BioGRID, IntAct, MINT |
| NR1H4 | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down | association, physical, physical association | 19833092, (Europe PMC) | 0.56 | BioGRID, IntAct |
| NR5A1 | anti tag coimmunoprecipitation | association | 24635384, (Europe PMC) | 0.35 | IntAct |
| PARP1 | Affinity Capture-Western, anti bait coimmunoprecipitation | association, physical | 16794079, 20085707, 21575865, (Europe PMC) | 0.53 | BioGRID, IntAct |
| PHKG2 | Affinity Capture-MS, tandem affinity purification | association, physical | 23455922, (Europe PMC) | 0.35 | BioGRID, IntAct |
| POT1 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 26496610, (Europe PMC) | 0.35 | BioGRID, IntAct |
| PPEF1 | pull down | association | 28330616, (Europe PMC) | 0.35 | IntAct |
| PPP6C | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down | association, physical | 20065038, 24255178, 28330616, (Europe PMC) | 0.53 | BioGRID, IntAct |
| PRKAB2 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| PRKCD | anti tag coimmunoprecipitation | association | 16611985, (Europe PMC) | 0.35 | IntAct |
| RARA | pull down | association, physical association | 25303530, (Europe PMC) | 0.50 | IntAct |
| RELA | Affinity Capture-MS, tandem affinity purification | physical, physical association | 14743216, 25331947, (Europe PMC) | 0.40 | BioGRID, IntAct |
| RELB | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| RIPK3 | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| RIPK4 | anti tag coimmunoprecipitation | association | 26972000, (Europe PMC) | 0.35 | IntAct |
| RUVBL1 | Affinity Capture-MS, pull down | association, physical | 20371770, (Europe PMC) | 0.35 | BioGRID, IntAct |
| SNW1 | Affinity Capture-MS, anti bait coimmunoprecipitation | association, physical | 20467437, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| SPI1 | anti tag coimmunoprecipitation, pull down | association, direct interaction | 21575865, (Europe PMC) | 0.52 | IntAct |
| TELO2 | Affinity Capture-MS, Affinity Capture-Western, affinity chromatography technology, anti bait coimmunoprecipitation, tandem affinity purification | association, physical | 18160036, 20427287, 20801936, (Europe PMC) | 0.60 | BioGRID, IntAct |
| TINF2 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 26496610, (Europe PMC) | 0.35 | BioGRID, IntAct |
| TNFRSF1A | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| TNFRSF1B | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| TOP1 | anti bait coimmunoprecipitation, pull down | association | 15848144, (Europe PMC) | 0.46 | IntAct |
| TOP2A | anti bait coimmunoprecipitation, anti tag coimmunoprecipitation | association | 20085707, (Europe PMC) | 0.46 | IntAct |
| TPTE | proximity-dependent biotin identification, pull down | association | 28330616, (Europe PMC) | 0.46 | IntAct |
| TRADD | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| TTI1 | Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, pull down | association, physical | 20371770, 20427287, 20810650, (Europe PMC) | 0.53 | BioGRID, IntAct |
| TTI2 | Affinity Capture-MS, tandem affinity purification | association, physical | 20801936, (Europe PMC) | 0.35 | BioGRID, IntAct |
| USF1 | Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay | association, phosphorylation reaction, physical, physical association | 19303849, (Europe PMC) | 0.62 | BioGRID, IntAct |
| VCAM1 | Affinity Capture-MS, cross-linking study | association, physical | 19738201, 22623428, (Europe PMC) | 0.35 | BioGRID, IntAct |
| XPA | Biochemical Activity, anti tag coimmunoprecipitation | association, physical | 16540648, 20304803, (Europe PMC) | 0.35 | BioGRID, IntAct |
| XRCC5 | Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-fractionation, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay, proximity ligation assay, x-ray crystallography | association, direct interaction, phosphorylation reaction, physical, physical association | 10446239, 10750018, 12393188, 15520013, 15758953, 16857680, 17308091, 19303849, 20023628, 20085707, 20711232, 21679440, 22404984, 26344197, 26496610, 9312071, (Europe PMC) | 0.88 | BioGRID, IntAct |
| XRCC6 | Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-fractionation, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay, proximity ligation assay | association, phosphorylation reaction, physical, physical association | 10064605, 10750018, 15520013, 17308091, 19303849, 20711232, 21575865, 21969602, 22939629, 26175416, 26496610, 8422676, (Europe PMC) | 0.87 | BioGRID, IntAct |
| YWHAB | coimmunoprecipitation | physical association | 15324660, (Europe PMC) | 0.40 | IntAct, MINT |
| YWHAG | coimmunoprecipitation | physical association | 15324660, (Europe PMC) | 0.40 | IntAct, MINT |
| YWHAZ | pull down, tandem affinity purification | association, physical association | 15161933, 20618440, (Europe PMC) | 0.35, 0.40 | IntAct, MINT |
| YY1 | Co-purification, cosedimentation through density gradient, pull down | association, physical, physical association | 18026119, (Europe PMC) | 0.50 | BioGRID, IntAct |
| ZIC2 | protein kinase assay | phosphorylation reaction | 18097573, (Europe PMC) | 0.44 | IntAct, MINT |
| Interacting partner | Detection method | Interaction type | PubMed IDs | Interaction Score | Source |
| APLF | pull down | association | 17396150, (Europe PMC) | 0.35 | IntAct, MINT |
| CDC5L | Affinity Capture-MS, Co-purification, anti bait coimmunoprecipitation | association, physical | 11101529, 20467437, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| E2F3 | pull down | association | 22157815, (Europe PMC) | 0.35 | IntAct, MINT |
| EP300 | Reconstituted Complex, anti bait coimmunoprecipitation | association, physical | 20808282, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| HSP90AB1 | Affinity Capture-MS, anti bait coimmunoprecipitation | association, physical | 16263121, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| ILF2 | Affinity Capture-MS, Affinity Capture-Western, Co-purification, affinity chromatography technology | association, physical | 17389650, 20808282, 9442054, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| JUN | Biochemical Activity, anti bait coimmunoprecipitation | association, physical | 25609649, 8464713, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| NFKB1 | tandem affinity purification | association | 25609649, (Europe PMC) | 0.35 | IntAct, MINT |
| NOTCH1 | Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, tandem affinity purification | association, physical | 23022380, (Europe PMC) | 0.46 | BioGRID, IntAct, MINT |
| SNW1 | Affinity Capture-MS, anti bait coimmunoprecipitation | association, physical | 20467437, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| YWHAB | coimmunoprecipitation | physical association | 15324660, (Europe PMC) | 0.40 | IntAct, MINT |
| YWHAG | coimmunoprecipitation | physical association | 15324660, (Europe PMC) | 0.40 | IntAct, MINT |
| YWHAZ | pull down, tandem affinity purification | association, physical association | 15161933, 20618440, (Europe PMC) | 0.35, 0.40 | IntAct, MINT |
| ZIC2 | protein kinase assay | phosphorylation reaction | 18097573, (Europe PMC) | 0.44 | IntAct, MINT |
| Interacting partner | Detection method | Interaction type | PubMed IDs | Interaction Score | Source |
| ADRB2 | Affinity Capture-MS | physical | 23798571, (Europe PMC) | NA | BioGRID |
| AHSA1 | Affinity Capture-Western | physical | 22504172, (Europe PMC) | NA | BioGRID |
| AICDA | Affinity Capture-Western, Reconstituted Complex | physical | 15634916, (Europe PMC) | NA | BioGRID |
| AIRE | Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation | association, physical, physical association | 20085707, (Europe PMC) | 0.50 | BioGRID, IntAct |
| AKT1 | Affinity Capture-Western, Biochemical Activity, Negative Genetic, Reconstituted Complex | genetic, physical | 15262962, 15678105, 28319113, (Europe PMC) | NA | BioGRID |
| AKT2 | Biochemical Activity | physical | 15678105, 16221682, (Europe PMC) | NA | BioGRID |
| AKTIP | Affinity Capture-Western | physical | 27535835, (Europe PMC) | NA | BioGRID |
| ALOX15 | Affinity Capture-Western | physical | 18785202, (Europe PMC) | NA | BioGRID |
| ANAPC2 | Affinity Capture-Western | physical | 26221070, (Europe PMC) | NA | BioGRID |
| AP1B1 | Protein-peptide | physical | 10608806, (Europe PMC) | NA | BioGRID |
| AP2M1 | Affinity Capture-MS | physical | 19380743, (Europe PMC) | NA | BioGRID |
| APEX1 | affinity chromatography technology | association | 20808282, (Europe PMC) | 0.35 | IntAct, MINT |
| APLF | pull down | association | 17396150, (Europe PMC) | 0.35 | IntAct, MINT |
| AR | Affinity Capture-MS, anti bait coimmunoprecipitation | association, physical, physical association | 15640154, 26175416, (Europe PMC) | 0.35, 0.50 | BioGRID, IntAct |
| ARHGEF6 | Affinity Capture-Western | physical | 19918261, (Europe PMC) | NA | BioGRID |
| ASB5 | Affinity Capture-MS | physical | 24337577, (Europe PMC) | NA | BioGRID |
| ATG101 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| ATG4C | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| ATM | Affinity Capture-Western, Protein-peptide | physical | 10464290, 10608806, (Europe PMC) | NA | BioGRID |
| ATOH1 | Affinity Capture-MS | physical | 27542412, (Europe PMC) | NA | BioGRID |
| ATRIP | Reconstituted Complex | physical | 15758953, (Europe PMC) | NA | BioGRID |
| ATRX | Affinity Capture-MS | physical | 23329831, (Europe PMC) | NA | BioGRID |
| AUP1 | Affinity Capture-MS | physical | 22119785, (Europe PMC) | NA | BioGRID |
| BAG3 | Affinity Capture-MS | physical | 23824909, (Europe PMC) | NA | BioGRID |
| BECN1 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| BIRC5 | Affinity Capture-Western | physical | 20394854, (Europe PMC) | NA | BioGRID |
| BMI1 | Affinity Capture-Western | physical | 20668194, (Europe PMC) | NA | BioGRID |
| BRCA1 | Protein-peptide | physical | 10608806, (Europe PMC) | NA | BioGRID |
| C1D | Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid | physical | 9679063, (Europe PMC) | NA | BioGRID |
| CAMKK2 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| CASP3 | Biochemical Activity | physical | 8804412, (Europe PMC) | NA | BioGRID |
| CBFA2T2 | anti tag coimmunoprecipitation | association | 27281218, (Europe PMC) | 0.35 | IntAct |
| CBX3 | tandem affinity purification | association | 21888893, (Europe PMC) | 0.35 | IntAct |
| CCDC8 | Affinity Capture-MS | physical | 24711643, (Europe PMC) | NA | BioGRID |
| CCNB1 | Affinity Capture-Western, Reconstituted Complex | physical | 26221070, (Europe PMC) | NA | BioGRID |
| CCNC | chromatography technology | physical association | 19047373, (Europe PMC) | 0.40 | IntAct |
| CD81 | anti bait coimmunoprecipitation | association | 26212323, (Europe PMC) | 0.35 | IntAct |
| CDC5L | Affinity Capture-MS, Co-purification, anti bait coimmunoprecipitation | association, physical | 11101529, 20467437, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| CDC73 | Affinity Capture-MS | physical | 27462432, (Europe PMC) | NA | BioGRID |
| CDK2 | Affinity Capture-MS | physical | 21319273, (Europe PMC) | NA | BioGRID |
| CDK4 | Negative Genetic | genetic | 28319113, (Europe PMC) | NA | BioGRID |
| CDK8 | anti bait coimmunoprecipitation | physical association | 19047373, (Europe PMC) | 0.40 | IntAct |
| CDK9 | Negative Genetic | genetic | 28319113, (Europe PMC) | NA | BioGRID |
| CENPA | Affinity Capture-MS, tandem affinity purification | association, physical | 20080577, (Europe PMC) | 0.35 | BioGRID, IntAct |
| CFTR | Affinity Capture-MS, anti bait coimmunoprecipitation | association, physical | 17110338, 26618866, (Europe PMC) | 0.35 | BioGRID, IntAct |
| CHAF1A | Affinity Capture-MS | physical | 21209461, (Europe PMC) | NA | BioGRID |
| CHD1L | Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation | physical, physical association | 19661379, 19666485, (Europe PMC) | 0.40 | BioGRID, IntAct |
| CHEK1 | Negative Genetic, Protein-peptide, Reconstituted Complex | genetic, physical | 10608806, 12756247, 28319113, (Europe PMC) | NA | BioGRID |
| CHEK2 | Biochemical Activity | physical | 10713094, (Europe PMC) | NA | BioGRID |
| CHUK | Biochemical Activity, Reconstituted Complex | physical | 9632806, (Europe PMC) | NA | BioGRID |
| CIB1 | Affinity Capture-Western, Reconstituted Complex, Two-hybrid | physical | 15190070, 9372844, (Europe PMC) | NA | BioGRID |
| CLK1 | Biochemical Activity | physical | 26167880, (Europe PMC) | NA | BioGRID |
| CLN3 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, 23464991, (Europe PMC) | 0.40 | BioGRID, IntAct |
| COPS5 | Affinity Capture-MS | physical | 21145461, (Europe PMC) | NA | BioGRID |
| CRY1 | Affinity Capture-MS | physical | 25756610, (Europe PMC) | NA | BioGRID |
| CRY2 | Affinity Capture-MS | physical | 25756610, (Europe PMC) | NA | BioGRID |
| CSNK2A1 | Affinity Capture-Western, Co-localization | physical | 22404984, (Europe PMC) | NA | BioGRID |
| CSNK2A2 | proximity ligation assay | physical association | 20711232, (Europe PMC) | 0.40 | IntAct |
| CTDP1 | Biochemical Activity, Protein-peptide | physical | 21450944, (Europe PMC) | NA | BioGRID |
| CTPS2 | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| CUL3 | Affinity Capture-MS | physical | 21145461, (Europe PMC) | NA | BioGRID |
| CUL5 | Affinity Capture-MS | physical | 21145461, (Europe PMC) | NA | BioGRID |
| CUL7 | Affinity Capture-MS | physical | 24711643, (Europe PMC) | NA | BioGRID |
| CWC27 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| CYLD | Affinity Capture-MS | physical | 27591049, (Europe PMC) | NA | BioGRID |
| DCAF1 | Biochemical Activity | physical | 22184063, (Europe PMC) | NA | BioGRID |
| DCLRE1B | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 26496610, (Europe PMC) | 0.35 | BioGRID, IntAct |
| DCLRE1C | Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation | association, physical, physical association | 11955432, 15456891, 15936993, 16857680, 22529269, (Europe PMC) | 0.61 | BioGRID, IntAct |
| DDA1 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| DDX5 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| DEAF1 | pull down | physical association | 22442688, (Europe PMC) | 0.40 | IntAct |
| DHX38 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| DHX9 | Affinity Capture-Western, Biochemical Activity, Co-fractionation | physical | 15613478, (Europe PMC) | NA | BioGRID |
| DNAJC7 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 26496610, (Europe PMC) | 0.35 | BioGRID, IntAct |
| DTNBP1 | pull down | association | 19142223, (Europe PMC) | 0.35 | IntAct |
| DUX4 | pull down | association | 26816005, (Europe PMC) | 0.35 | IntAct |
| E2F3 | pull down | association | 22157815, (Europe PMC) | 0.35 | IntAct, MINT |
| E4F1 | Protein-peptide | physical | 10608806, (Europe PMC) | NA | BioGRID |
| EED | Affinity Capture-MS | physical | 24457600, (Europe PMC) | NA | BioGRID |
| EFTUD2 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| EGFR | Affinity Capture-MS, proximity ligation assay | physical, physical association | 23178489, 23956138, (Europe PMC) | 0.40 | BioGRID, IntAct |
| EHD1 | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| EIF2S2 | Co-purification | physical | 9442054, (Europe PMC) | NA | BioGRID |
| EIF4EBP1 | Biochemical Activity | physical | 10713094, (Europe PMC) | NA | BioGRID |
| ELAVL1 | Affinity Capture-RNA | physical | 19322201, (Europe PMC) | NA | BioGRID |
| ELP1 | Affinity Capture-MS | physical | 18303054, (Europe PMC) | NA | BioGRID |
| EMD | Affinity Capture-MS | physical | 23443559, (Europe PMC) | NA | BioGRID |
| ENSG00000096060 | chromatin immunoprecipitation assay | association | 21575865, (Europe PMC) | 0.35 | IntAct |
| ENSG00000124126 | chromatin immunoprecipitation assay | association | 26175416, (Europe PMC) | 0.35 | IntAct |
| ENSG00000132470 | chromatin immunoprecipitation assay | association | 26175416, (Europe PMC) | 0.35 | IntAct |
| ENSG00000134318 | chromatin immunoprecipitation assay | association | 26175416, (Europe PMC) | 0.35 | IntAct |
| ENSG00000142515 | chromatin immunoprecipitation assay | association | 21575865, 26175416, (Europe PMC) | 0.53 | IntAct |
| ENSG00000144837 | chromatin immunoprecipitation assay | association | 21575865, 26175416, (Europe PMC) | 0.53 | IntAct |
| ENSG00000160182 | chromatin immunoprecipitation assay | association | 25303530, (Europe PMC) | 0.35 | IntAct |
| ENSG00000169710 | chromatin immunoprecipitation assay | association | 19303849, (Europe PMC) | 0.35 | IntAct |
| ENSG00000184012 | chromatin immunoprecipitation assay | association | 21575865, 26175416, (Europe PMC) | 0.53 | IntAct |
| ENSG00000196208 | chromatin immunoprecipitation assay | association | 25303530, (Europe PMC) | 0.35 | IntAct |
| ENSG00000196620 | chromatin immunoprecipitation assay | association | 26175416, (Europe PMC) | 0.35 | IntAct |
| ENSG00000197888 | chromatin immunoprecipitation assay | association | 26175416, (Europe PMC) | 0.35 | IntAct |
| EP300 | Reconstituted Complex, anti bait coimmunoprecipitation | association, physical | 20808282, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| EPHA1 | Affinity Capture-MS | physical | 28514442, (Europe PMC) | NA | BioGRID |
| ERG | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, chromatin immunoprecipitation assay, pull down | association, direct interaction, physical | 21575865, 24591637, (Europe PMC) | 0.35, 0.44, 0.46 | BioGRID, IntAct |
| ESR1 | Affinity Capture-MS, Affinity Capture-Western, affinity chromatography technology | association, physical | 16794079, 21182205, (Europe PMC) | 0.35 | BioGRID, IntAct |
| ESR2 | affinity chromatography technology | association | 21182203, (Europe PMC) | 0.35 | IntAct |
| ETS1 | anti tag coimmunoprecipitation, pull down | association, direct interaction | 21575865, (Europe PMC) | 0.52 | IntAct |
| ETV1 | anti tag coimmunoprecipitation, pull down | association, direct interaction | 21575865, (Europe PMC) | 0.52 | IntAct |
| FAF2 | Affinity Capture-MS | physical | 22119785, (Europe PMC) | NA | BioGRID |
| FANCD2 | Synthetic Lethality | genetic | 24036544, (Europe PMC) | NA | BioGRID |
| FBXO6 | Affinity Capture-MS | physical | 22268729, (Europe PMC) | NA | BioGRID |
| FLII | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| FN1 | Affinity Capture-MS | physical | 19738201, (Europe PMC) | NA | BioGRID |
| FOXRED2 | Affinity Capture-MS | physical | 22119785, (Europe PMC) | NA | BioGRID |
| FZR1 | Affinity Capture-Western | physical | 26221070, (Europe PMC) | NA | BioGRID |
| GABARAP | anti tag coimmunoprecipitation | association | 20562859, (Europe PMC) | 0.35 | IntAct |
| GABARAPL1 | anti tag coimmunoprecipitation | association | 20562859, (Europe PMC) | 0.35 | IntAct |
| GABARAPL2 | anti tag coimmunoprecipitation | association | 20562859, (Europe PMC) | 0.35 | IntAct |
| GOLPH3 | protein kinase assay | phosphorylation reaction | 24485452, (Europe PMC) | 0.44 | IntAct |
| GRB2 | pull down | association | 12577067, (Europe PMC) | 0.35 | IntAct |
| GRK5 | Affinity Capture-MS | physical | 22952844, (Europe PMC) | NA | BioGRID |
| GSK3A | Biochemical Activity | physical | 15678105, (Europe PMC) | NA | BioGRID |
| GSK3B | Biochemical Activity | physical | 15678105, (Europe PMC) | NA | BioGRID |
| GTF2I | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| GZMB | Biochemical Activity | physical | 8760815, (Europe PMC) | NA | BioGRID |
| H2AFX | Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation | association, physical | 14627815, 15613478, 18406329, 20085707, 20356835, 22184063, (Europe PMC) | 0.35 | BioGRID, IntAct |
| H3F3A | Affinity Capture-MS | physical | 20504901, (Europe PMC) | NA | BioGRID |
| HDAC11 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 23752268, (Europe PMC) | 0.35 | BioGRID, IntAct |
| HDAC3 | Biochemical Activity | physical | 17242407, (Europe PMC) | NA | BioGRID |
| HDAC5 | Affinity Capture-MS | physical | 21081666, (Europe PMC) | NA | BioGRID |
| HDGF | Affinity Capture-MS, Affinity Capture-Western, pull down, tandem affinity purification | association, physical | 21907836, (Europe PMC) | 0.46 | BioGRID, IntAct |
| HDLBP | Affinity Capture-Western | physical | 15723802, (Europe PMC) | NA | BioGRID |
| HIST1H1A | Biochemical Activity | physical | 20356835, (Europe PMC) | NA | BioGRID |
| HIST1H1C | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex | physical | 18258596, (Europe PMC) | NA | BioGRID |
| HIST1H3A | Co-localization, proximity-dependent biotin identification, tandem affinity purification | association, physical | 20080577, 22404984, 29568061, (Europe PMC) | 0.53 | BioGRID, IntAct |
| HIST1H3E | Affinity Capture-MS, Co-purification | physical | 20080577, 20504901, 26527279, (Europe PMC) | NA | BioGRID |
| HNRNPA1 | Biochemical Activity | physical | 14704337, (Europe PMC) | NA | BioGRID |
| HNRNPC | Biochemical Activity | physical | 14704337, (Europe PMC) | NA | BioGRID |
| HOXB7 | Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down | association, physical, physical association | 17308091, (Europe PMC) | 0.50 | BioGRID, IntAct |
| HSF1 | Reconstituted Complex | physical | 9325337, (Europe PMC) | NA | BioGRID |
| HSP90AA1 | Affinity Capture-MS | physical | 16263121, (Europe PMC) | NA | BioGRID |
| HSP90AB1 | Affinity Capture-MS, anti bait coimmunoprecipitation | association, physical | 16263121, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| HSPA5 | Affinity Capture-MS | physical | 26496610, (Europe PMC) | NA | BioGRID |
| HSPA5 | anti tag coimmunoprecipitation | association | 26496610, (Europe PMC) | 0.35 | IntAct |
| HSPA8 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| IGF1R | Negative Genetic | genetic | 28319113, (Europe PMC) | NA | BioGRID |
| IGFBP3 | anti bait coimmunoprecipitation, proximity ligation assay | association, physical association | 23178489, (Europe PMC) | 0.50 | IntAct |
| IKBKB | Biochemical Activity | physical | 9632806, (Europe PMC) | NA | BioGRID |
| IKBKG | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| ILF2 | Affinity Capture-MS, Affinity Capture-Western, Co-purification, affinity chromatography technology | association, physical | 17389650, 20808282, 9442054, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| ILF3 | Affinity Capture-Western, Co-purification | physical | 21969602, 9442054, (Europe PMC) | NA | BioGRID |
| ILK | Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification | association, physical | 23455922, 25852190, (Europe PMC) | 0.53 | BioGRID, IntAct |
| IQCB1 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 21565611, (Europe PMC) | 0.35 | BioGRID, IntAct |
| ISG15 | pull down | association | 26259872, (Europe PMC) | 0.35 | IntAct |
| ITGA4 | Affinity Capture-MS | physical | 22623428, (Europe PMC) | NA | BioGRID |
| JUN | Biochemical Activity, anti bait coimmunoprecipitation | association, physical | 25609649, 8464713, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| KAT2A | Biochemical Activity | physical | 9488450, (Europe PMC) | NA | BioGRID |
| KAT5 | Affinity Capture-Western | physical | 16603769, (Europe PMC) | NA | BioGRID |
| KAT8 | Affinity Capture-MS, Affinity Capture-Western | physical | 20479123, (Europe PMC) | NA | BioGRID |
| KEAP1 | Affinity Capture-MS | physical | 27621311, (Europe PMC) | NA | BioGRID |
| LGR4 | Affinity Capture-MS | physical | 24639526, (Europe PMC) | NA | BioGRID |
| LIG4 | Affinity Capture-Western, Biochemical Activity, Protein-peptide, anti bait coimmunoprecipitation | association, physical | 10608806, 15194694, 22529269, (Europe PMC) | 0.35 | BioGRID, IntAct |
| LMNA | Affinity Capture-Western, anti tag coimmunoprecipitation | association, physical | 21346760, (Europe PMC) | 0.35 | BioGRID, IntAct |
| LNX1 | Affinity Capture-MS | physical | 29121065, (Europe PMC) | NA | BioGRID |
| LPAR4 | Affinity Capture-MS | physical | 28514442, (Europe PMC) | NA | BioGRID |
| LRRFIP1 | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| LRRK2 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 17400507, 19826009, (Europe PMC) | 0.35 | BioGRID, IntAct |
| LYN | Reconstituted Complex | physical | 9748231, (Europe PMC) | NA | BioGRID |
| MAP1LC3A | anti tag coimmunoprecipitation | association | 20562859, (Europe PMC) | 0.35 | IntAct |
| MAP1LC3B | anti tag coimmunoprecipitation | association | 20562859, (Europe PMC) | 0.35 | IntAct |
| MAP3K3 | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| MAPK8 | Biochemical Activity | physical | 11749722, (Europe PMC) | NA | BioGRID |
| MAPK9 | Affinity Capture-Western, Biochemical Activity | physical | 11749722, 22366412, (Europe PMC) | NA | BioGRID |
| MAPKAP1 | anti bait coimmunoprecipitation | association, physical association | 24365180, (Europe PMC) | 0.50 | IntAct |
| MBP | Biochemical Activity | physical | 15147269, (Europe PMC) | NA | BioGRID |
| MCM2 | Affinity Capture-MS | physical | 25963833, (Europe PMC) | NA | BioGRID |
| MDC1 | Affinity Capture-MS, Affinity Capture-Western, Co-localization, Reconstituted Complex | physical | 15377652, (Europe PMC) | NA | BioGRID |
| MED13 | anti bait coimmunoprecipitation | physical association | 19047373, (Europe PMC) | 0.40 | IntAct |
| METTL1 | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| MEX3C | Affinity Capture-MS | physical | 26471122, (Europe PMC) | NA | BioGRID |
| MGMT | Affinity Capture-MS | physical | 16226712, (Europe PMC) | NA | BioGRID |
| MKNK1 | Two-hybrid, two hybrid pooling approach | physical, physical association | 20936779, (Europe PMC) | 0.37 | BioGRID, IntAct |
| MLH1 | Affinity Capture-MS | physical | 17148452, (Europe PMC) | NA | BioGRID |
| MRE11 | Protein-peptide | physical | 10608806, (Europe PMC) | NA | BioGRID |
| MSH6 | Affinity Capture-Western | physical | 21075794, (Europe PMC) | NA | BioGRID |
| MSL3 | Affinity Capture-Western | physical | 20479123, (Europe PMC) | NA | BioGRID |
| MTF1 | Affinity Capture-MS | physical | 28416769, (Europe PMC) | NA | BioGRID |
| MTNR1B | Two-hybrid, two hybrid | physical, physical association | 26514267, (Europe PMC) | 0.37 | BioGRID, IntAct |
| MTOR | Negative Genetic, anti bait coimmunoprecipitation | association, genetic | 24365180, 28319113, (Europe PMC) | 0.35 | BioGRID, IntAct |
| MYC | Affinity Capture-MS, Synthetic Lethality, tandem affinity purification | association, genetic, physical | 17314511, 25495526, (Europe PMC) | 0.35 | BioGRID, IntAct |
| NBN | Affinity Capture-MS, Reconstituted Complex | physical | 15758953, (Europe PMC) | NA | BioGRID |
| NCF1 | Biochemical Activity | physical | 9914162, (Europe PMC) | NA | BioGRID |
| NCF2 | Biochemical Activity | physical | 9914162, (Europe PMC) | NA | BioGRID |
| NCF4 | Biochemical Activity | physical | 9914162, (Europe PMC) | NA | BioGRID |
| NCOA6 | Affinity Capture-MS, Biochemical Activity | physical | 10823961, (Europe PMC) | NA | BioGRID |
| NFATC2 | Affinity Capture-MS | physical | 27637333, (Europe PMC) | NA | BioGRID |
| NFKB1 | tandem affinity purification | association | 25609649, (Europe PMC) | 0.35 | IntAct, MINT |
| NFKB2 | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| NFKBIE | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| NIPSNAP2 | Affinity Capture-MS | physical | 20562859, (Europe PMC) | NA | BioGRID |
| NIPSNAP2 | anti tag coimmunoprecipitation | physical association | 20562859, (Europe PMC) | 0.40 | IntAct |
| NOS2 | Affinity Capture-MS | physical | 23438482, (Europe PMC) | NA | BioGRID |
| NOTCH1 | Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, tandem affinity purification | association, physical | 23022380, (Europe PMC) | 0.46 | BioGRID, IntAct, MINT |
| NR1H4 | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down | association, physical, physical association | 19833092, (Europe PMC) | 0.56 | BioGRID, IntAct |
| NR3C1 | Biochemical Activity | physical | 9038175, (Europe PMC) | NA | BioGRID |
| NR5A1 | anti tag coimmunoprecipitation | association | 24635384, (Europe PMC) | 0.35 | IntAct |
| NTRK1 | Affinity Capture-MS | physical | 25921289, (Europe PMC) | NA | BioGRID |
| NUCB1 | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| NUP107 | Proximity Label-MS | physical | 24927568, (Europe PMC) | NA | BioGRID |
| NUP35 | Proximity Label-MS | physical | 24927568, (Europe PMC) | NA | BioGRID |
| NUP85 | Proximity Label-MS | physical | 24927568, (Europe PMC) | NA | BioGRID |
| OBSL1 | Affinity Capture-MS | physical | 24711643, (Europe PMC) | NA | BioGRID |
| PAN2 | Affinity Capture-MS | physical | 23398456, (Europe PMC) | NA | BioGRID |
| PARP1 | Affinity Capture-Western, anti bait coimmunoprecipitation | association, physical | 16794079, 20085707, 21575865, (Europe PMC) | 0.53 | BioGRID, IntAct |
| PCNA | Affinity Capture-MS | physical | 12171929, (Europe PMC) | NA | BioGRID |
| PDX1 | Biochemical Activity | physical | 16166097, (Europe PMC) | NA | BioGRID |
| PGR | Affinity Capture-Western, Biochemical Activity | physical | 10750018, (Europe PMC) | NA | BioGRID |
| PHGDH | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| PHKG2 | Affinity Capture-MS, tandem affinity purification | association, physical | 23455922, (Europe PMC) | 0.35 | BioGRID, IntAct |
| PIDD1 | Affinity Capture-MS | physical | 21415862, (Europe PMC) | NA | BioGRID |
| PINK1 | Affinity Capture-MS | physical | 21151955, (Europe PMC) | NA | BioGRID |
| PMS2 | Affinity Capture-MS | physical | 17148452, (Europe PMC) | NA | BioGRID |
| PNKP | Affinity Capture-MS | physical | 15385968, (Europe PMC) | NA | BioGRID |
| POT1 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 26496610, (Europe PMC) | 0.35 | BioGRID, IntAct |
| POU2F1 | Biochemical Activity | physical | 14612514, 17213819, (Europe PMC) | NA | BioGRID |
| POU5F1 | Affinity Capture-MS | physical | 26687479, (Europe PMC) | NA | BioGRID |
| PPEF1 | pull down | association | 28330616, (Europe PMC) | 0.35 | IntAct |
| PPP2CA | Affinity Capture-Western | physical | 20065038, (Europe PMC) | NA | BioGRID |
| PPP6C | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down | association, physical | 20065038, 24255178, 28330616, (Europe PMC) | 0.53 | BioGRID, IntAct |
| PPP6R1 | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex | physical | 20065038, (Europe PMC) | NA | BioGRID |
| PPP6R2 | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex | physical | 20065038, 28514442, (Europe PMC) | NA | BioGRID |
| PPP6R3 | Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex | physical | 20065038, (Europe PMC) | NA | BioGRID |
| PRDX1 | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| PRKAB2 | Affinity Capture-MS, anti tag coimmunoprecipitation | physical, physical association | 20562859, (Europe PMC) | 0.40 | BioGRID, IntAct |
| PRKCD | anti tag coimmunoprecipitation | association | 16611985, (Europe PMC) | 0.35 | IntAct |
| PRKDC | Biochemical Activity | physical | 10750018, 20065038, (Europe PMC) | NA | BioGRID |
| PRPF8 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| PTER | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| RAD17 | Protein-peptide | physical | 10608806, (Europe PMC) | NA | BioGRID |
| RAD21 | Affinity Capture-Western, Co-fractionation | physical | 22145905, 22939629, (Europe PMC) | NA | BioGRID |
| RANBP2 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| RARA | pull down | association, physical association | 25303530, (Europe PMC) | 0.50 | IntAct |
| RASSF1 | Protein-peptide | physical | 10608806, (Europe PMC) | NA | BioGRID |
| RBBP8 | Protein-peptide | physical | 10608806, (Europe PMC) | NA | BioGRID |
| RBM25 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| RECQL5 | Affinity Capture-MS | physical | 19270065, (Europe PMC) | NA | BioGRID |
| RELA | Affinity Capture-MS, tandem affinity purification | physical, physical association | 14743216, 25331947, (Europe PMC) | 0.40 | BioGRID, IntAct |
| RELB | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| RFC2 | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| RIPK3 | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| RIPK4 | anti tag coimmunoprecipitation | association | 26972000, (Europe PMC) | 0.35 | IntAct |
| RNF144A | Affinity Capture-Western, Biochemical Activity, Reconstituted Complex | physical | 24979766, (Europe PMC) | NA | BioGRID |
| RPA1 | Affinity Capture-MS, Reconstituted Complex | physical | 10064605, 21504906, 24332808, (Europe PMC) | NA | BioGRID |
| RPA2 | Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex | physical | 10064605, 10713094, 16540648, 24332808, 8943020, 9295339, (Europe PMC) | NA | BioGRID |
| RPA3 | Affinity Capture-MS | physical | 24332808, (Europe PMC) | NA | BioGRID |
| RPS11 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| RRM2 | Negative Genetic | genetic | 28319113, (Europe PMC) | NA | BioGRID |
| RTCB | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| RTRAF | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| RUVBL1 | Affinity Capture-MS, pull down | association, physical | 20371770, (Europe PMC) | 0.35 | BioGRID, IntAct |
| RYK | Affinity Capture-MS | physical | 21875946, (Europe PMC) | NA | BioGRID |
| SAP25 | Affinity Capture-MS | physical | 16449650, (Europe PMC) | NA | BioGRID |
| SCARNA22 | Affinity Capture-RNA | physical | 22751105, (Europe PMC) | NA | BioGRID |
| SF3B6 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| SHC1 | Affinity Capture-MS | physical | 19380743, (Europe PMC) | NA | BioGRID |
| SIRT6 | Affinity Capture-MS, Affinity Capture-Western, Co-localization | physical | 20157594, 24169447, (Europe PMC) | NA | BioGRID |
| SIRT7 | Affinity Capture-MS | physical | 22586326, (Europe PMC) | NA | BioGRID |
| SKI | Affinity Capture-MS | physical | 25670202, (Europe PMC) | NA | BioGRID |
| SMARCA5 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| SMARCAD1 | Affinity Capture-MS | physical | 21549307, (Europe PMC) | NA | BioGRID |
| SNRPA | Co-fractionation | physical | 22863883, (Europe PMC) | NA | BioGRID |
| SNW1 | Affinity Capture-MS, anti bait coimmunoprecipitation | association, physical | 20467437, (Europe PMC) | 0.35 | BioGRID, IntAct, MINT |
| SP1 | Biochemical Activity | physical | 8422676, (Europe PMC) | NA | BioGRID |
| SPI1 | anti tag coimmunoprecipitation, pull down | association, direct interaction | 21575865, (Europe PMC) | 0.52 | IntAct |
| SRF | Biochemical Activity | physical | 8407951, (Europe PMC) | NA | BioGRID |
| SRP14 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| SRP54 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| SRSF10 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| STAU1 | Affinity Capture-MS | physical | 23125841, (Europe PMC) | NA | BioGRID |
| SUMO2 | Reconstituted Complex | physical | 19394292, (Europe PMC) | NA | BioGRID |
| TELO2 | Affinity Capture-MS, Affinity Capture-Western, affinity chromatography technology, anti bait coimmunoprecipitation, tandem affinity purification | association, physical | 18160036, 20427287, 20801936, (Europe PMC) | 0.60 | BioGRID, IntAct |
| TERF1 | Affinity Capture-Western | physical | 18160036, (Europe PMC) | NA | BioGRID |
| TES | Affinity Capture-MS | physical | 28378594, (Europe PMC) | NA | BioGRID |
| THOC6 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| THRA | Affinity Capture-MS, Reconstituted Complex | physical | 17242407, (Europe PMC) | NA | BioGRID |
| THRB | Affinity Capture-MS, Reconstituted Complex | physical | 17242407, (Europe PMC) | NA | BioGRID |
| THYN1 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| TINF2 | Affinity Capture-MS, anti tag coimmunoprecipitation | association, physical | 26496610, (Europe PMC) | 0.35 | BioGRID, IntAct |
| TNFRSF1A | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| TNFRSF1B | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| TOP1 | anti bait coimmunoprecipitation, pull down | association | 15848144, (Europe PMC) | 0.46 | IntAct |
| TOP2A | anti bait coimmunoprecipitation, anti tag coimmunoprecipitation | association | 20085707, (Europe PMC) | 0.46 | IntAct |
| TP53 | Affinity Capture-Western, Biochemical Activity, Protein-peptide | physical | 10608806, 10713094, 12756247, 19918261, 25362358, 9363941, 9679063, 9744860, (Europe PMC) | NA | BioGRID |
| TPR | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| TPTE | proximity-dependent biotin identification, pull down | association | 28330616, (Europe PMC) | 0.46 | IntAct |
| TRA2B | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| TRADD | tandem affinity purification | physical association | 14743216, (Europe PMC) | 0.40 | IntAct |
| TRIM25 | Affinity Capture-MS | physical | 29117863, (Europe PMC) | NA | BioGRID |
| TTI1 | Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, pull down | association, physical | 20371770, 20427287, 20810650, (Europe PMC) | 0.53 | BioGRID, IntAct |
| TTI2 | Affinity Capture-MS, tandem affinity purification | association, physical | 20801936, (Europe PMC) | 0.35 | BioGRID, IntAct |
| U2AF2 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| UBAC2 | Affinity Capture-MS | physical | 22119785, (Europe PMC) | NA | BioGRID |
| UBE2I | Biochemical Activity | physical | 19596686, (Europe PMC) | NA | BioGRID |
| UBXN6 | Affinity Capture-MS | physical | 22337587, (Europe PMC) | NA | BioGRID |
| USF1 | Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay | association, phosphorylation reaction, physical, physical association | 19303849, (Europe PMC) | 0.62 | BioGRID, IntAct |
| VCAM1 | Affinity Capture-MS, cross-linking study | association, physical | 19738201, 22623428, (Europe PMC) | 0.35 | BioGRID, IntAct |
| VHL | Negative Genetic | genetic | 28319113, (Europe PMC) | NA | BioGRID |
| WRN | Affinity Capture-Western, Biochemical Activity, Protein-peptide | physical | 10608806, 11889123, (Europe PMC) | NA | BioGRID |
| XPA | Biochemical Activity, anti tag coimmunoprecipitation | association, physical | 16540648, 20304803, (Europe PMC) | 0.35 | BioGRID, IntAct |
| XRCC1 | Affinity Capture-Western | physical | 18678286, (Europe PMC) | NA | BioGRID |
| XRCC4 | Affinity Capture-Western, Co-fractionation | physical | 15194694, 15520013, 22939629, (Europe PMC) | NA | BioGRID |
| XRCC5 | Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-fractionation, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay, proximity ligation assay, x-ray crystallography | association, direct interaction, phosphorylation reaction, physical, physical association | 10446239, 10750018, 12393188, 15520013, 15758953, 16857680, 17308091, 19303849, 20023628, 20085707, 20711232, 21679440, 22404984, 26344197, 26496610, 9312071, (Europe PMC) | 0.88 | BioGRID, IntAct |
| XRCC6 | Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-fractionation, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay, proximity ligation assay | association, phosphorylation reaction, physical, physical association | 10064605, 10750018, 15520013, 17308091, 19303849, 20711232, 21575865, 21969602, 22939629, 26175416, 26496610, 8422676, (Europe PMC) | 0.87 | BioGRID, IntAct |
| YBX1 | Co-fractionation | physical | 22939629, (Europe PMC) | NA | BioGRID |
| YWHAB | coimmunoprecipitation | physical association | 15324660, (Europe PMC) | 0.40 | IntAct, MINT |
| YWHAG | coimmunoprecipitation | physical association | 15324660, (Europe PMC) | 0.40 | IntAct, MINT |
| YWHAQ | Affinity Capture-MS, Reconstituted Complex | physical | 15161933, 20618440, (Europe PMC) | NA | BioGRID |
| YWHAZ | pull down, tandem affinity purification | association, physical association | 15161933, 20618440, (Europe PMC) | 0.35, 0.40 | IntAct, MINT |
| YY1 | Co-purification, cosedimentation through density gradient, pull down | association, physical, physical association | 18026119, (Europe PMC) | 0.50 | BioGRID, IntAct |
| ZIC2 | protein kinase assay | phosphorylation reaction | 18097573, (Europe PMC) | 0.44 | IntAct, MINT |
| ZNF746 | Affinity Capture-MS | physical | 25315684, (Europe PMC) | NA | BioGRID |