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Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
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336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
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299 KEGG pathways;
876 Reactome pathways;
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last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023

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DEPOD - Download

Human phosphatases in DEPOD and other phosphatase-databases (Phosphatome.net and iEKPD)

Human phosphatase mapping
Phosphatases (GeneName, GeneID, UniProt_AC, EC number, CATH number, Activity status)
DEPOD-2015 Family
DEPOD-2019 (CATH based superfamily, Family, Subfamily)
Phosphatome.net (SCOP Fold, SCOP fold-based superfamily, SCOP Family, SCOP Subfamily, Included in phosphatome or not)
iEKPD (Type, Group, Family)
Historic classification (Substrate specificity based Superfamily, Family, Subfamily)

Phosphataserelated Gene Ontology (GO) terms used to compile the list of human phosphatases in DEPOD

Phosphatase-related GO terms
GO term
Type
Description

Human phosphatase-substrate interaction and dephosphorylation sites

Interactions between human phosphatases and their protein substrates along with the dephosphorylation sites
New pairs added to DEPOD-2019
Phosphatase UniProt_AC numbers
Phosphatase entry names in DEPOD
Substrate UniProt_AC numbers
Substrate entry names in DEPOD
Dephosphorylation sites
5-amino acid window around the dephosphorylation site
Bioassay type
PubMed IDs
Reliability score

Interactions between human phosphatases and their non-protein substrates along with the dephosphorylation sites
Phosphatase UniProt_AC numbers
Phosphatase entry names in DEPOD
Substrate ChEBI ID
Substrate KEGG ID
Substrate ChEBI name
Dephosphorylation sites
Bioassay type
PubMed IDs
Reliability score

Relations between protein kinases, protein phosphatases and their common substrate proteins (PSKRs)

Inter-relations between human phosphatases, kinases and their common substrates
Substrate UniProt_AC
Substrate gene names
Phosphosite and 5 amino acid window around it
Phosphorylating protein kinases (taken from PhosphoSitePlus, PhosphoELM and HPRD)
Bioassay/s (from aforementioned databases)
Literature support (from aforementioned databases)
Source database/s
Dephosphosite and 5 amino window around it
Dephosphorylating protein phosphatases
Literature support

Pathways mapped on phosphatases and their substrates

KEGG pathways and the phosphatases and their protein substrates involved therein
Reactome pathways and the phosphatases and their protein substrates involved therein

Pathway ID (KEGG or REACTOME)
Pathway Name
Pathway description
Dephosphorylated proteins involved in the pathway
Dephosphorylating phosphatases involved in the pathway

Mapping of DEPOD entries across different databases

Mapping across different databases
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