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Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
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336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
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299 KEGG pathways;
876 Reactome pathways;
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last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023

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Pathways involving human phosphatases and their substrates

KEGG pathID PathName
hsa00010Glycolysis / Gluconeogenesis - Homo sapiens (human)
hsa00020Citrate cycle (TCA cycle) - Homo sapiens (human)
hsa00030Pentose phosphate pathway - Homo sapiens (human)
hsa00040Pentose and glucuronate interconversions - Homo sapiens (human)
hsa00051Fructose and mannose metabolism - Homo sapiens (human)
hsa00052Galactose metabolism - Homo sapiens (human)
hsa00100Steroid biosynthesis - Homo sapiens (human)
hsa00190Oxidative phosphorylation - Homo sapiens (human)
hsa00220Arginine biosynthesis - Homo sapiens (human)
hsa00230Purine metabolism - Homo sapiens (human)
hsa00240Pyrimidine metabolism - Homo sapiens (human)
hsa00250Alanine, aspartate and glutamate metabolism - Homo sapiens (human)
hsa00260Glycine, serine and threonine metabolism - Homo sapiens (human)
hsa00270Cysteine and methionine metabolism - Homo sapiens (human)
hsa00280Valine, leucine and isoleucine degradation - Homo sapiens (human)
hsa00310Lysine degradation - Homo sapiens (human)
hsa00330Arginine and proline metabolism - Homo sapiens (human)
hsa00400Phenylalanine, tyrosine and tryptophan biosynthesis - Homo sapiens (human)
hsa00410beta-Alanine metabolism - Homo sapiens (human)
hsa00430Taurine and hypotaurine metabolism - Homo sapiens (human)
hsa00440Phosphonate and phosphinate metabolism - Homo sapiens (human)
hsa00500Starch and sucrose metabolism - Homo sapiens (human)
hsa00510N-Glycan biosynthesis - Homo sapiens (human)
hsa00520Amino sugar and nucleotide sugar metabolism - Homo sapiens (human)
hsa00521NA
hsa00523NA
hsa00524Neomycin, kanamycin and gentamicin biosynthesis - Homo sapiens (human)
hsa00525NA
hsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human)
hsa00534Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human)
hsa00540NA
hsa00561Glycerolipid metabolism - Homo sapiens (human)
hsa00562Inositol phosphate metabolism - Homo sapiens (human)
hsa00564Glycerophospholipid metabolism - Homo sapiens (human)
hsa00565Ether lipid metabolism - Homo sapiens (human)
hsa00590Arachidonic acid metabolism - Homo sapiens (human)
hsa00600Sphingolipid metabolism - Homo sapiens (human)
hsa00620Pyruvate metabolism - Homo sapiens (human)
hsa00630Glyoxylate and dicarboxylate metabolism - Homo sapiens (human)
hsa00640Propanoate metabolism - Homo sapiens (human)
hsa00650Butanoate metabolism - Homo sapiens (human)
hsa00680NA
hsa00710NA
hsa00730Thiamine metabolism - Homo sapiens (human)
hsa00740Riboflavin metabolism - Homo sapiens (human)
hsa00750Vitamin B6 metabolism - Homo sapiens (human)
hsa00760Nicotinate and nicotinamide metabolism - Homo sapiens (human)
hsa00770Pantothenate and CoA biosynthesis - Homo sapiens (human)
hsa00790Folate biosynthesis - Homo sapiens (human)
hsa00900Terpenoid backbone biosynthesis - Homo sapiens (human)
hsa00906NA
hsa00908NA
hsa00909NA
hsa00920Sulfur metabolism - Homo sapiens (human)
hsa00970Aminoacyl-tRNA biosynthesis - Homo sapiens (human)
hsa00981NA
hsa00983Drug metabolism - other enzymes - Homo sapiens (human)
hsa00999NA
hsa01057NA
hsa01060NA
hsa01061NA
hsa01062NA
hsa01063NA
hsa01064NA
hsa01065NA
hsa01066NA
hsa01070NA
hsa01100Metabolic pathways - Homo sapiens (human)
hsa01110NA
hsa01120NA
hsa01130NA
hsa01200Carbon metabolism - Homo sapiens (human)
hsa01230Biosynthesis of amino acids - Homo sapiens (human)
hsa01503NA
hsa01521EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
hsa01522Endocrine resistance - Homo sapiens (human)
hsa01523Antifolate resistance - Homo sapiens (human)
hsa01524Platinum drug resistance - Homo sapiens (human)
hsa02010ABC transporters - Homo sapiens (human)
hsa02060NA
hsa03013RNA transport - Homo sapiens (human)
hsa03015mRNA surveillance pathway - Homo sapiens (human)
hsa03020RNA polymerase - Homo sapiens (human)
hsa03030DNA replication - Homo sapiens (human)
hsa03040Spliceosome - Homo sapiens (human)
hsa03320PPAR signaling pathway - Homo sapiens (human)
hsa03410Base excision repair - Homo sapiens (human)
hsa03420Nucleotide excision repair - Homo sapiens (human)
hsa03430Mismatch repair - Homo sapiens (human)
hsa03440Homologous recombination - Homo sapiens (human)
hsa03450Non-homologous end-joining - Homo sapiens (human)
hsa03460Fanconi anemia pathway - Homo sapiens (human)
hsa04010MAPK signaling pathway - Homo sapiens (human)
hsa04012ErbB signaling pathway - Homo sapiens (human)
hsa04014Ras signaling pathway - Homo sapiens (human)
hsa04015Rap1 signaling pathway - Homo sapiens (human)
hsa04020Calcium signaling pathway - Homo sapiens (human)
hsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
hsa04024cAMP signaling pathway - Homo sapiens (human)
hsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
hsa04062Chemokine signaling pathway - Homo sapiens (human)
hsa04064NF-kappa B signaling pathway - Homo sapiens (human)
hsa04066HIF-1 signaling pathway - Homo sapiens (human)
hsa04068FoxO signaling pathway - Homo sapiens (human)
hsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
hsa04071Sphingolipid signaling pathway - Homo sapiens (human)
hsa04072Phospholipase D signaling pathway - Homo sapiens (human)
hsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
hsa04110Cell cycle - Homo sapiens (human)
hsa04114Oocyte meiosis - Homo sapiens (human)
hsa04115p53 signaling pathway - Homo sapiens (human)
hsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
hsa04136Autophagy - other - Homo sapiens (human)
hsa04137Mitophagy - animal - Homo sapiens (human)
hsa04138NA
hsa04140Autophagy - animal - Homo sapiens (human)
hsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
hsa04142Lysosome - Homo sapiens (human)
hsa04144Endocytosis - Homo sapiens (human)
hsa04145Phagosome - Homo sapiens (human)
hsa04146Peroxisome - Homo sapiens (human)
hsa04150mTOR signaling pathway - Homo sapiens (human)
hsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
hsa04152AMPK signaling pathway - Homo sapiens (human)
hsa04210Apoptosis - Homo sapiens (human)
hsa04211Longevity regulating pathway - Homo sapiens (human)
hsa04212NA
hsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
hsa04215Apoptosis - multiple species - Homo sapiens (human)
hsa04216Ferroptosis - Homo sapiens (human)
hsa04217Necroptosis - Homo sapiens (human)
hsa04218Cellular senescence - Homo sapiens (human)
hsa04260Cardiac muscle contraction - Homo sapiens (human)
hsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
hsa04270Vascular smooth muscle contraction - Homo sapiens (human)
hsa04310Wnt signaling pathway - Homo sapiens (human)
hsa04340Hedgehog signaling pathway - Homo sapiens (human)
hsa04350TGF-beta signaling pathway - Homo sapiens (human)
hsa04360Axon guidance - Homo sapiens (human)
hsa04370VEGF signaling pathway - Homo sapiens (human)
hsa04371Apelin signaling pathway - Homo sapiens (human)
hsa04380Osteoclast differentiation - Homo sapiens (human)
hsa04390Hippo signaling pathway - Homo sapiens (human)
hsa04392Hippo signaling pathway - multiple species - Homo sapiens (human)
hsa04510Focal adhesion - Homo sapiens (human)
hsa04512ECM-receptor interaction - Homo sapiens (human)
hsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
hsa04520Adherens junction - Homo sapiens (human)
hsa04530Tight junction - Homo sapiens (human)
hsa04540Gap junction - Homo sapiens (human)
hsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
hsa04611Platelet activation - Homo sapiens (human)
hsa04612Antigen processing and presentation - Homo sapiens (human)
hsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
hsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
hsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
hsa04623Cytosolic DNA-sensing pathway - Homo sapiens (human)
hsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
hsa04630JAK-STAT signaling pathway - Homo sapiens (human)
hsa04640Hematopoietic cell lineage - Homo sapiens (human)
hsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
hsa04657IL-17 signaling pathway - Homo sapiens (human)
hsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
hsa04659Th17 cell differentiation - Homo sapiens (human)
hsa04660T cell receptor signaling pathway - Homo sapiens (human)
hsa04662B cell receptor signaling pathway - Homo sapiens (human)
hsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
hsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
hsa04668TNF signaling pathway - Homo sapiens (human)
hsa04670Leukocyte transendothelial migration - Homo sapiens (human)
hsa04710Circadian rhythm - Homo sapiens (human)
hsa04713Circadian entrainment - Homo sapiens (human)
hsa04714Thermogenesis - Homo sapiens (human)
hsa04720Long-term potentiation - Homo sapiens (human)
hsa04721Synaptic vesicle cycle - Homo sapiens (human)
hsa04722Neurotrophin signaling pathway - Homo sapiens (human)
hsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
hsa04724Glutamatergic synapse - Homo sapiens (human)
hsa04725Cholinergic synapse - Homo sapiens (human)
hsa04726Serotonergic synapse - Homo sapiens (human)
hsa04727GABAergic synapse - Homo sapiens (human)
hsa04728Dopaminergic synapse - Homo sapiens (human)
hsa04730Long-term depression - Homo sapiens (human)
hsa04740Olfactory transduction - Homo sapiens (human)
hsa04742Taste transduction - Homo sapiens (human)
hsa04744Phototransduction - Homo sapiens (human)
hsa04745NA
hsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
hsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
hsa04910Insulin signaling pathway - Homo sapiens (human)
hsa04911Insulin secretion - Homo sapiens (human)
hsa04912GnRH signaling pathway - Homo sapiens (human)
hsa04913Ovarian steroidogenesis - Homo sapiens (human)
hsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
hsa04915Estrogen signaling pathway - Homo sapiens (human)
hsa04916Melanogenesis - Homo sapiens (human)
hsa04917Prolactin signaling pathway - Homo sapiens (human)
hsa04918Thyroid hormone synthesis - Homo sapiens (human)
hsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
hsa04920Adipocytokine signaling pathway - Homo sapiens (human)
hsa04921Oxytocin signaling pathway - Homo sapiens (human)
hsa04922Glucagon signaling pathway - Homo sapiens (human)
hsa04923Regulation of lipolysis in adipocytes - Homo sapiens (human)
hsa04924Renin secretion - Homo sapiens (human)
hsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
hsa04926Relaxin signaling pathway - Homo sapiens (human)
hsa04927Cortisol synthesis and secretion - Homo sapiens (human)
hsa04928Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
hsa04930Type II diabetes mellitus - Homo sapiens (human)
hsa04931Insulin resistance - Homo sapiens (human)
hsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
hsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
hsa04934Cushing syndrome - Homo sapiens (human)
hsa04940Type I diabetes mellitus - Homo sapiens (human)
hsa04950Maturity onset diabetes of the young - Homo sapiens (human)
hsa04960Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
hsa04961Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
hsa04962Vasopressin-regulated water reabsorption - Homo sapiens (human)
hsa04966Collecting duct acid secretion - Homo sapiens (human)
hsa04970Salivary secretion - Homo sapiens (human)
hsa04971Gastric acid secretion - Homo sapiens (human)
hsa04972Pancreatic secretion - Homo sapiens (human)
hsa04973Carbohydrate digestion and absorption - Homo sapiens (human)
hsa04974Protein digestion and absorption - Homo sapiens (human)
hsa04975Fat digestion and absorption - Homo sapiens (human)
hsa04976Bile secretion - Homo sapiens (human)
hsa04977Vitamin digestion and absorption - Homo sapiens (human)
hsa04978Mineral absorption - Homo sapiens (human)
hsa04979Cholesterol metabolism - Homo sapiens (human)
hsa05010Alzheimer disease - Homo sapiens (human)
hsa05012Parkinson disease - Homo sapiens (human)
hsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
hsa05016Huntington disease - Homo sapiens (human)
hsa05020Prion diseases - Homo sapiens (human)
hsa05030Cocaine addiction - Homo sapiens (human)
hsa05031Amphetamine addiction - Homo sapiens (human)
hsa05032Morphine addiction - Homo sapiens (human)
hsa05034Alcoholism - Homo sapiens (human)
hsa05100Bacterial invasion of epithelial cells - Homo sapiens (human)
hsa05110Vibrio cholerae infection - Homo sapiens (human)
hsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
hsa05130Pathogenic Escherichia coli infection - Homo sapiens (human)
hsa05131Shigellosis - Homo sapiens (human)
hsa05132Salmonella infection - Homo sapiens (human)
hsa05133Pertussis - Homo sapiens (human)
hsa05134Legionellosis - Homo sapiens (human)
hsa05140Leishmaniasis - Homo sapiens (human)
hsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
hsa05143African trypanosomiasis - Homo sapiens (human)
hsa05144Malaria - Homo sapiens (human)
hsa05145Toxoplasmosis - Homo sapiens (human)
hsa05146Amoebiasis - Homo sapiens (human)
hsa05150Staphylococcus aureus infection - Homo sapiens (human)
hsa05152Tuberculosis - Homo sapiens (human)
hsa05160Hepatitis C - Homo sapiens (human)
hsa05161Hepatitis B - Homo sapiens (human)
hsa05162Measles - Homo sapiens (human)
hsa05163Human cytomegalovirus infection - Homo sapiens (human)
hsa05164Influenza A - Homo sapiens (human)
hsa05165Human papillomavirus infection - Homo sapiens (human)
hsa05166Human T-cell leukemia virus 1 infection - Homo sapiens (human)
hsa05167Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
hsa05168Herpes simplex infection - Homo sapiens (human)
hsa05169Epstein-Barr virus infection - Homo sapiens (human)
hsa05170Human immunodeficiency virus 1 infection - Homo sapiens (human)
hsa05200Pathways in cancer - Homo sapiens (human)
hsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
hsa05203Viral carcinogenesis - Homo sapiens (human)
hsa05205Proteoglycans in cancer - Homo sapiens (human)
hsa05206MicroRNAs in cancer - Homo sapiens (human)
hsa05210Colorectal cancer - Homo sapiens (human)
hsa05211Renal cell carcinoma - Homo sapiens (human)
hsa05212Pancreatic cancer - Homo sapiens (human)
hsa05213Endometrial cancer - Homo sapiens (human)
hsa05214Glioma - Homo sapiens (human)
hsa05215Prostate cancer - Homo sapiens (human)
hsa05216Thyroid cancer - Homo sapiens (human)
hsa05217Basal cell carcinoma - Homo sapiens (human)
hsa05218Melanoma - Homo sapiens (human)
hsa05219Bladder cancer - Homo sapiens (human)
hsa05220Chronic myeloid leukemia - Homo sapiens (human)
hsa05221Acute myeloid leukemia - Homo sapiens (human)
hsa05222Small cell lung cancer - Homo sapiens (human)
hsa05223Non-small cell lung cancer - Homo sapiens (human)
hsa05224Breast cancer - Homo sapiens (human)
hsa05225Hepatocellular carcinoma - Homo sapiens (human)
hsa05226Gastric cancer - Homo sapiens (human)
hsa05230Central carbon metabolism in cancer - Homo sapiens (human)
hsa05231Choline metabolism in cancer - Homo sapiens (human)
hsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
hsa05322Systemic lupus erythematosus - Homo sapiens (human)
hsa05323Rheumatoid arthritis - Homo sapiens (human)
hsa05332Graft-versus-host disease - Homo sapiens (human)
hsa05340Primary immunodeficiency - Homo sapiens (human)
hsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
hsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)
hsa05416Viral myocarditis - Homo sapiens (human)
hsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)


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