Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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KEGG Pathway - Adipocytokine signaling pathway - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| G6PC | P35575 | Protein substrates of this phosphatase are not reported yet | alpha-D-glucose 6-phosphate, beta-D-glucose 6-phosphate, |
| PTPN11 | Q06124 | SPRY2, SPRY1, JAK2, MPZL1, EGFR, PDGFRB, SRC, SELE, IRS1, KDR, STAT1, STAT5A, PXN, STAT5B, SIRPA, ARHGAP5, GAB1, PTK2B, PAG1, GAB2, MAP3K4, ERBB2, LCK, CD28, ERBB2, PDCD1, ERBB4, | Non-protein substrates of this phosphatase are not reported yet |
| G6PC3 | Q9BUM1 | Protein substrates of this phosphatase are not reported yet | alpha-D-glucose 6-phosphate, beta-D-glucose 6-phosphate, |
| G6PC2 | Q9NQR9 | Protein substrates of this phosphatase are not reported yet | alpha-D-glucose 6-phosphate, beta-D-glucose 6-phosphate, |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| IKBKB | O14920 | PPP2CA, PPP2CB, PPM1A, PPM1B, PPM1M, |
| CHUK | O15111 | PPP2CA, PPP2CB, |
| JAK2 | O60674 | PTPRC, PTPN1, PTPN6, PTPN11, |
| CD36 | P16671 | ALPI, |
| NFKBIA | P25963 | PTPN1, PTPN13, PPP3CB, PPP3CC, PPP2CB, PPP2CA, PPP3CA, |
| AKT1 | P31749 | ACP1, PHLPP1, PHLPP2, PPP2CA, PPP2CB, PPP1CA, PPP1CB, PPP1CC, CTDSP1, |
| AKT2 | P31751 | PHLPP1, PHLPP2, |
| IRS1 | P35568 | PTPN1, PTPN13, PTPN11, PPP1CA, PPP1CB, PPP1CC, |
| STAT3 | P40763 | DUSP22, PTPN1, PTPRD, PTPRT, PTPN2, |
| MAPK8 | P45983 | DUSP22, DUSP8, DUSP18, DUSP1, DUSP9, DUSP10, PPP2CA, PPP2CB, DUSP3, |
| MAPK9 | P45984 | DUSP19, DUSP1, DUSP4, DUSP9, DUSP10, DUSP16, DUSP3, DUSP14, |
| MAPK10 | P53779 | DUSP16, |
| RELA | Q04206 | PPP2CA, PPP4C, PPP2CB, |
| PTPN11 | Q06124 | PTPN1, |
| TRAF2 | Q12933 | PPP2CA, PPP2CB, |
| PRKAA1 | Q13131 | PPP2CA, PPP2CB, |
| AKT3 | Q9Y243 | PHLPP1, PHLPP2, PPP2CA, PPP2CB, |
| Non-protein substrates in this pathway |
Non-protein substrates involved in this pathway are unknown (yet!)