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Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
SPRY2
Gene Name  | SPRY2 (QuickGO) | (A quick tutorial to explore the interctive visulaization) Representative structure: 3BUM |
| Synonyms | SPRY2 | |
| Protein Name | SPRY2 | |
| Alternative Name(s) | Protein sprouty homolog 2;Spry-2; | |
| Protein Family | Belongs to the sprouty family | |
| EntrezGene ID | 10253 (Comparitive Toxicogenomics) | |
| UniProt AC (Human) | O43597 (protein sequence) | |
| Enzyme Class | N/A | |
| Molecular Weight | 34688 Dalton | |
| Protein Length | 315 amino acids (AA) | |
| Genome Browsers | NCBI | ENSG00000136158 (Ensembl) | UCSC | |
| Crosslinking annotations | Query our ID-mapping table | |
| Orthologues | Quest For Orthologues (QFO) | GeneTree | eggNOG - ENOG410IHQY | eggNOG - ENOG4111S05 | |
| Phosphorylation Network | Visualize | |
| Domain organization, Expression, Diseases | (show / hide) |
| Protein Domain | InterPro | Pfam | SMART | 3D Structure | PDB | DrugPort | ModBase | SwissModel |
| Polypeptide organization (Pfam)  | |||
| Gene Expression | Gene Expression Atlas | Disease | OMIM | DisGeNet | COSMIC | ClinVar |
| Protein-protein interactions | STRING | IntAct | MINT | BioGRID | ||
| Phosphosites | Phospho.ELM | PhosphoSitePlus |
| Localization, Function, Catalytic activity and Sequence | (show / hide) |
| Localization (UniProt annotation) | |||
| Cytoplasm, cytoskeleton Cell projection, ruffle membrane Note=Associated with microtubulesin unstimulated cells but is translocated to the membrane rufflesin cells stimulated ith EGF (epidermal growth factor) | |||
| Function (UniProt annotation) | |||
| May function as an antagonist of fibroblast growthfactor (FGF) pathways and may negatively modulate respiratoryorganogenesis | |||
| Catalytic Activity (UniProt annotation) | |||
| N/A | |||
| Protein Sequence | |||
| MEARAQSGNGSQPLLQTPRDGGRQRGEPDPRDALTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHE RLHGLPEHRQPPRLQHSQVHSSARAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGSSFSSGPVADGIIRVQPKSELKP GELKPLSKEDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADN PCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT | |||
| Motif information from Eukaryotic Linear Motif atlas (ELM) | (show / hide) |
| ELM Motif | Motif Instance
| Description | Motif Regex |
| NA | NA | NA | NA |
| Gene Ontology (P: Process; F: Function and C: Component terms) | (show / hide) | |
| GO:0000132 | P:establishment of mitotic spindle orientation |
| GO:0005634 | C:nucleus |
| GO:0005829 | C:cytosol |
| GO:0005856 | C:cytoskeleton |
| GO:0005874 | C:microtubule |
| GO:0005886 | C:plasma membrane |
| GO:0007605 | P:sensory perception of sound |
| GO:0008285 | P:negative regulation of cell proliferation |
| GO:0010628 | P:positive regulation of gene expression |
| GO:0010801 | P:negative regulation of peptidyl-threonine phosphorylation |
| GO:0015630 | C:microtubule cytoskeleton |
| GO:0016020 | C:membrane |
| GO:0016525 | P:negative regulation of angiogenesis |
| GO:0019901 | F:protein kinase binding |
| GO:0030291 | F:protein serine/threonine kinase inhibitor activity |
| GO:0030335 | P:positive regulation of cell migration |
| GO:0031345 | P:negative regulation of cell projection organization |
| GO:0032587 | C:ruffle membrane |
| GO:0033138 | P:positive regulation of peptidyl-serine phosphorylation |
| GO:0034260 | P:negative regulation of GTPase activity |
| GO:0035924 | P:cellular response to vascular endothelial growth factor stimulus |
| GO:0040037 | P:negative regulation of fibroblast growth factor receptor signaling pathway |
| GO:0042059 | P:negative regulation of epidermal growth factor receptor signaling pathway |
| GO:0042472 | P:inner ear morphogenesis |
| GO:0043066 | P:negative regulation of apoptotic process |
| GO:0043407 | P:negative regulation of MAP kinase activity |
| GO:0043539 | F:protein serine/threonine kinase activator activity |
| GO:0045165 | P:cell fate commitment |
| GO:0045595 | P:regulation of cell differentiation |
| GO:0046580 | P:negative regulation of Ras protein signal transduction |
| GO:0051387 | P:negative regulation of neurotrophin TRK receptor signaling pathway |
| GO:0051897 | P:positive regulation of protein kinase B signaling |
| GO:0060437 | P:lung growth |
| GO:0060449 | P:bud elongation involved in lung branching |
| GO:0070373 | P:negative regulation of ERK1 and ERK2 cascade |
| GO:0070374 | P:positive regulation of ERK1 and ERK2 cascade |
| GO:1900747 | P:negative regulation of vascular endothelial growth factor signaling pathway |
| GO:1990830 | P:cellular response to leukemia inhibitory factor |
SPRY2 is dephosphorylated by following phosphatases:
| Phosphatase Gene Name | Phosphatase UniProt_AC | DephosphoSite and sequence (+/-5) in SPRY2 (O43597) | Bioassay Type | PubMed ID | View in Europe PMC | Reliability of the interaction |
| PTPN11 | Q06124 | NA | In vitro and in vivo | 15031289, | Europe PMC |  |
| Pathway ID | Pathway Name | Pathway Description (KEGG) |
| hsa05206 | MicroRNAs in cancer | MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article. |
| Pathway ID | Pathway Name | Pathway Description (KEGG) |
| R-HSA-1295596 | Spry regulation of FGF signaling. | Sprouty was initially characterized as a negative regulator of FGFR signaling in Drosophila. Human cells contain four genes encoding Sprouty proteins, of which Spry2 is the best studied and most widely expressed. Spry proteins modulate the duration and extent of signaling through the MAPK cascade after FGF stimulation, although the mechanism appears to depend on the particular biological context. Some studies have suggested that Sprouty binds to GRB2 and interferes with the recruitment of GRB2-SOS1 to the receptor, while others have shown that Sprouty interferes with the MAPK cascade at the level of RAF activation. In addition to modulating the MAPK pathway in response to FGF stimulation, Sprouty itself appears to be subject to complex post-translational modification that regulates its activity and stability |
| R-HSA-182971 | EGFR downregulation. | Regulation of receptor tyrosine kinase (RTK) activity is implicated in the control of almost all cellular functions. One of the best understood RTKs is epidermal growth factor receptor (EGFR). Growth factors can bind to EGFR and activate it to initiate signalling cascades within the cell. EGFRs can also be recruited to clathrin-coated pits which can be internalised into endocytic vesicles. From here, EGFRs can either be recycled back to the plasma membrane or directed to lysosomes for destruction.This provides a mechanism by which EGFR signalling is negatively regulated and controls the strength and duration of EGFR-induced signals. It also prevents EGFR hyperactivation as commonly seen in tumorigenesis.The proto-oncogene Cbl can negatively regulate EGFR signalling. The Cbl family of RING-type ubiquitin ligases are able to poly-ubiquitinate EGFR, an essential step in EGFR degradation. All Cbl proteins have a unique domain that recognises phosphorylated tyrosine residues on activated EGFRs. They also direct the ubiquitination and degradation of activated EGFRs by recruiting ubiquitin-conjugation enzymes. Cbl proteins function by specifically targeting activated EGFRs and mediating their down-regulation, thus providing a means by which signaling processes can be negatively regulated.Cbl also promotes receptor internalization via it's interaction with an adaptor protein, CIN85 (Cbl-interacting protein of 85kDa). CIN85 binds to Cbl via it's SH3 domain and is enhanced by the EGFR-induced tyrosine phosphorylation of Cbl. The proline-rich region of CIN85 interacts with endophilins which are regulatory components of clathrin-coated vesicles (CCVs). Endophilins bind to membranes and induce membrane curvature, in conjunction with other proteins involved in CCV formation. The rapid recruitment of endophilin to the activated receptor complex by CIN85 is the mechanism which controls receptor internalization |
| Interacting partner | Detection method | Interaction type | PubMed IDs | Interaction Score | Source |
| AQP1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| ATRIP | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| BRAF | Affinity Capture-Western, Reconstituted Complex | physical | 19690147, (Europe PMC) | NA | BioGRID |
| C19orf66 | Two-hybrid | physical | 25416956, (Europe PMC) | NA | BioGRID |
| CAB39 | Affinity Capture-MS | physical | 26186194, (Europe PMC) | NA | BioGRID |
| CATSPER1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| CBL | Affinity Capture-Western, Co-crystal Structure, FRET, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, isothermal titration calorimetry, x-ray crystallography | association, direct interaction, physical, physical association | 11053437, 11983899, 12234920, 12593795, 12593796, 12815057, 15004239, 15962011, 16246327, 16479008, 16893902, 17255109, 17974561, 18273061, 20124286, 20461437, 20877636, 21596750, (Europe PMC) | 0.86 | BioGRID, IntAct, MINT |
| CHRD | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| CREB5 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| CRIP2 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| CRMP1 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| CSTB | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| CTH | Affinity Capture-MS | physical | 28514442, (Europe PMC) | NA | BioGRID |
| CTNNA3 | Affinity Capture-MS | physical | 23718855, (Europe PMC) | NA | BioGRID |
| CTSB | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| DGCR6 | Two-hybrid | physical | 24722188, (Europe PMC) | NA | BioGRID |
| DNM2 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| EGLN1 | Affinity Capture-Western | physical | 22006925, (Europe PMC) | NA | BioGRID |
| EGLN2 | Affinity Capture-Western | physical | 22006925, (Europe PMC) | NA | BioGRID |
| EGLN3 | Affinity Capture-Western | physical | 22006925, (Europe PMC) | NA | BioGRID |
| EIF4E2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| ELAVL1 | Affinity Capture-RNA | physical | 19322201, (Europe PMC) | NA | BioGRID |
| FAIM | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| FAM219A | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| FBN1 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| FRS2 | Affinity Capture-Western | physical | 15004239, (Europe PMC) | NA | BioGRID |
| FRS3 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| GNE | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| GP9 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| GPRIN2 | Two-hybrid, two hybrid pooling approach | physical, physical association | 16189514, (Europe PMC) | 0.37 | BioGRID, IntAct |
| GRAP2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| GRB2 | Affinity Capture-Western, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, filter binding | association, direct interaction, physical, physical association | 10940627, 15004239, 16893902, 17255109, 17974561, (Europe PMC) | 0.59 | BioGRID, IntAct, MINT |
| HEXIM2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| HGS | Affinity Capture-Western | physical | 17320394, (Europe PMC) | NA | BioGRID |
| HIF1A | Affinity Capture-Western, Co-localization | physical | 27281823, (Europe PMC) | NA | BioGRID |
| HRAS | Affinity Capture-Western | physical | 18048363, (Europe PMC) | NA | BioGRID |
| HSD3B7 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 21516116, 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| ITSN1 | Two-hybrid | physical | 22558309, (Europe PMC) | NA | BioGRID |
| KDM1A | Two-hybrid, two hybrid | physical, physical association | 23455924, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| KIF1A | Two-hybrid | physical | 24722188, (Europe PMC) | NA | BioGRID |
| KRTAP10-1 | Two-hybrid | physical | 25416956, (Europe PMC) | NA | BioGRID |
| KRTAP10-11 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP10-3 | Two-hybrid | physical | 25416956, (Europe PMC) | NA | BioGRID |
| KRTAP10-5 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP10-8 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP10-9 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP4-11 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP4-12 | Two-hybrid, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 16189514, 25416956, (Europe PMC) | 0.67 | BioGRID, IntAct |
| KRTAP4-7 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP5-6 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP5-9 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP9-2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP9-4 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LASP1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LCE1B | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LCE2D | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LCE3C | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LCE3E | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LCE4A | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LONRF1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| MAPKBP1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| MDFI | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| MEOX2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| MID2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| MKNK1 | Affinity Capture-Western, Biochemical Activity | physical | 16479008, (Europe PMC) | NA | BioGRID |
| MLLT6 | Two-hybrid | physical | 25416956, (Europe PMC) | NA | BioGRID |
| NCK2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| NEDD4 | Affinity Capture-Western, Reconstituted Complex | physical | 19864419, (Europe PMC) | NA | BioGRID |
| NR1H2 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| NUBP1 | Two-hybrid | physical | 21900206, (Europe PMC) | NA | BioGRID |
| OTX1 | Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 21516116, 25416956, (Europe PMC) | 0.67 | BioGRID, IntAct, MINT |
| PACSIN3 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| PLS1 | Affinity Capture-MS | physical | 26186194, 28514442, (Europe PMC) | NA | BioGRID |
| PLSCR1 | Two-hybrid, two hybrid pooling approach | physical, physical association | 16189514, (Europe PMC) | 0.37 | BioGRID, IntAct |
| PPP2CA | Affinity Capture-Western | physical | 17255109, 17974561, (Europe PMC) | NA | BioGRID |
| PPP2R1A | Affinity Capture-Western | physical | 17255109, (Europe PMC) | NA | BioGRID |
| PRKAB2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 24722188, 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| PRKCD | Affinity Capture-Western, Far Western | physical | 19458088, (Europe PMC) | NA | BioGRID |
| PRKD1 | Affinity Capture-Western, Far Western | physical | 19458088, (Europe PMC) | NA | BioGRID |
| PTGER3 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| RAF1 | Affinity Capture-Western | physical | 12717443, (Europe PMC) | NA | BioGRID |
| RTF2 | Two-hybrid | physical | 21900206, (Europe PMC) | NA | BioGRID |
| RUNX1T1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| S100A13 | Affinity Capture-MS | physical | 28514442, (Europe PMC) | NA | BioGRID |
| SDHB | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| SEMA5B | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| SH3KBP1 | Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation | association, physical, physical association | 15962011, 25416956, (Europe PMC) | 0.50 | BioGRID, IntAct, MINT |
| SIAH2 | Reconstituted Complex | physical | 16888801, (Europe PMC) | NA | BioGRID |
| SNX3 | Affinity Capture-MS | physical | 26186194, 28514442, (Europe PMC) | NA | BioGRID |
| SPRY1 | Affinity Capture-Western, Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 15004239, 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| SPRY2 | Two-hybrid, two hybrid array | physical, physical association | 25416956, (Europe PMC) | 0.37 | BioGRID, IntAct |
| SPRY4 | Affinity Capture-Western | physical | 15004239, (Europe PMC) | NA | BioGRID |
| STK16 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| TCAF1 | Two-hybrid | physical | 25416956, (Europe PMC) | NA | BioGRID |
| TES | Affinity Capture-MS | physical | 28514442, (Europe PMC) | NA | BioGRID |
| TESK1 | Affinity Capture-Western | physical | 17974561, (Europe PMC) | NA | BioGRID |
| TMEM14B | Two-hybrid | physical | 21516116, (Europe PMC) | NA | BioGRID |
| TNS2 | Two-hybrid, two hybrid array | physical, physical association | 25814554, (Europe PMC) | 0.37 | BioGRID, IntAct |
| TRAF2 | Two-hybrid, two hybrid pooling approach | physical, physical association | 16189514, (Europe PMC) | 0.37 | BioGRID, IntAct |
| TRIM51 | Two-hybrid, two hybrid pooling approach | physical, physical association | 16189514, (Europe PMC) | 0.37 | BioGRID, IntAct |
| TXNDC5 | Two-hybrid | physical | 25416956, (Europe PMC) | NA | BioGRID |
| UBASH3A | Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 21516116, 25416956, (Europe PMC) | 0.67 | BioGRID, IntAct, MINT |
| UBASH3B | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| UBE2D2 | Affinity Capture-MS | physical | 26186194, 28514442, (Europe PMC) | NA | BioGRID |
| UBE2E3 | Affinity Capture-MS | physical | 26186194, (Europe PMC) | NA | BioGRID |
| UBR1 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| USP20 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| VANGL1 | Affinity Capture-MS | physical | 26186194, (Europe PMC) | NA | BioGRID |
| VANGL2 | Affinity Capture-MS | physical | 26186194, (Europe PMC) | NA | BioGRID |
| VHL | Affinity Capture-Western | physical | 22006925, (Europe PMC) | NA | BioGRID |
| VPS25 | Affinity Capture-Western, Two-hybrid | physical | 21543492, (Europe PMC) | NA | BioGRID |
| VPS36 | Two-hybrid | physical | 21543492, (Europe PMC) | NA | BioGRID |
| ZBTB16 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| ZDHHC17 | Affinity Capture-MS, Affinity Capture-Western, Two-hybrid | physical | 24705354, 25416956, 26186194, 28514442, (Europe PMC) | NA | BioGRID |
| ZFP36 | Affinity Capture-RNA | physical | 21784977, (Europe PMC) | NA | BioGRID |
| ZNF266 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| ZNF417 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| ZNF587 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| Interacting partner | Detection method | Interaction type | PubMed IDs | Interaction Score | Source |
| AQP1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| ATRIP | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| CATSPER1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| CBL | Affinity Capture-Western, Co-crystal Structure, FRET, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, isothermal titration calorimetry, x-ray crystallography | association, direct interaction, physical, physical association | 11053437, 11983899, 12234920, 12593795, 12593796, 12815057, 15004239, 15962011, 16246327, 16479008, 16893902, 17255109, 17974561, 18273061, 20124286, 20461437, 20877636, 21596750, (Europe PMC) | 0.86 | BioGRID, IntAct, MINT |
| CHRD | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| CHRNG | two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid | physical association | 25910212, (Europe PMC) | 0.56 | IntAct |
| CREB5 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| CRIP2 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| CRMP1 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| CSTB | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| CTSB | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| DNM2 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| EBI-10171679 | two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical association | 25416956, (Europe PMC) | 0.56 | IntAct |
| EBI-10173330 | two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical association | 25416956, (Europe PMC) | 0.56 | IntAct |
| EBI-16428938 | two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical association | 26871637, (Europe PMC) | 0.56 | IntAct |
| EIF4E2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| FAIM | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| FAM219A | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| FBN1 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| FRS3 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| GNE | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| GP9 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| GPRIN2 | Two-hybrid, two hybrid pooling approach | physical, physical association | 16189514, (Europe PMC) | 0.37 | BioGRID, IntAct |
| GRAP2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| GRB2 | Affinity Capture-Western, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, filter binding | association, direct interaction, physical, physical association | 10940627, 15004239, 16893902, 17255109, 17974561, (Europe PMC) | 0.59 | BioGRID, IntAct, MINT |
| GRN | two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid | physical association | 25910212, (Europe PMC) | 0.56 | IntAct |
| HEXIM2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| HSD3B7 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 21516116, 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KDM1A | Two-hybrid, two hybrid | physical, physical association | 23455924, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| KRTAP10-11 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP10-5 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP10-8 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP10-9 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP4-11 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP4-12 | Two-hybrid, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 16189514, 25416956, (Europe PMC) | 0.67 | BioGRID, IntAct |
| KRTAP4-7 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP5-6 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP5-9 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP9-2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP9-4 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LASP1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LCE1B | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LCE2D | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LCE3C | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LCE3E | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LCE4A | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LONRF1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| MAPKBP1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| MDFI | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| MEOX2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| MID2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| NCK2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| NR1H2 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| NUBP1 | two hybrid | physical association | 21900206, (Europe PMC) | 0.37 | IntAct, MINT |
| OTX1 | Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 21516116, 25416956, (Europe PMC) | 0.67 | BioGRID, IntAct, MINT |
| PACSIN3 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| PLSCR1 | Two-hybrid, two hybrid pooling approach | physical, physical association | 16189514, (Europe PMC) | 0.37 | BioGRID, IntAct |
| PRKAB2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 24722188, 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| PTGER3 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| RTFDC1 | two hybrid | physical association | 21900206, (Europe PMC) | 0.37 | IntAct, MINT |
| RUNX1T1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| RYDEN | two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical association | 25416956, (Europe PMC) | 0.56 | IntAct |
| SDHB | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| SEMA5B | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| SH3KBP1 | Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation | association, physical, physical association | 15962011, 25416956, (Europe PMC) | 0.50 | BioGRID, IntAct, MINT |
| SPRY1 | Affinity Capture-Western, Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 15004239, 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| SPRY2 | Two-hybrid, two hybrid array | physical, physical association | 25416956, (Europe PMC) | 0.37 | BioGRID, IntAct |
| STK16 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| TCAF1 | two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical association | 25416956, (Europe PMC) | 0.56 | IntAct |
| TNS2 | Two-hybrid, two hybrid array | physical, physical association | 25814554, (Europe PMC) | 0.37 | BioGRID, IntAct |
| TRAF2 | Two-hybrid, two hybrid pooling approach | physical, physical association | 16189514, (Europe PMC) | 0.37 | BioGRID, IntAct |
| TRIM51 | Two-hybrid, two hybrid pooling approach | physical, physical association | 16189514, (Europe PMC) | 0.37 | BioGRID, IntAct |
| UBASH3A | Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 21516116, 25416956, (Europe PMC) | 0.67 | BioGRID, IntAct, MINT |
| UBASH3B | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| UBR1 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| USP20 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| ZBTB16 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| ZDHHC17 | two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical association | 25416956, (Europe PMC) | 0.56 | IntAct |
| ZNF266 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| ZNF417 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| ZNF587 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| Interacting partner | Detection method | Interaction type | PubMed IDs | Interaction Score | Source |
| CRIP2 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| CRMP1 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| CSTB | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| CTSB | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| DNM2 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| FAM219A | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| FBN1 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| GRB2 | Affinity Capture-Western, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, filter binding | association, direct interaction, physical, physical association | 10940627, 15004239, 16893902, 17255109, 17974561, (Europe PMC) | 0.59 | BioGRID, IntAct, MINT |
| KDM1A | Two-hybrid, two hybrid | physical, physical association | 23455924, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| NR1H2 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| NUBP1 | two hybrid | physical association | 21900206, (Europe PMC) | 0.37 | IntAct, MINT |
| OTX1 | Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 21516116, 25416956, (Europe PMC) | 0.67 | BioGRID, IntAct, MINT |
| RTFDC1 | two hybrid | physical association | 21900206, (Europe PMC) | 0.37 | IntAct, MINT |
| SDHB | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| SEMA5B | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| SH3KBP1 | Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation | association, physical, physical association | 15962011, 25416956, (Europe PMC) | 0.50 | BioGRID, IntAct, MINT |
| UBASH3A | Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 21516116, 25416956, (Europe PMC) | 0.67 | BioGRID, IntAct, MINT |
| UBR1 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| ZBTB16 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| ZNF266 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| Interacting partner | Detection method | Interaction type | PubMed IDs | Interaction Score | Source |
| AQP1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| ATRIP | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| BRAF | Affinity Capture-Western, Reconstituted Complex | physical | 19690147, (Europe PMC) | NA | BioGRID |
| C19orf66 | Two-hybrid | physical | 25416956, (Europe PMC) | NA | BioGRID |
| CAB39 | Affinity Capture-MS | physical | 26186194, (Europe PMC) | NA | BioGRID |
| CATSPER1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| CBL | Affinity Capture-Western, Co-crystal Structure, FRET, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, isothermal titration calorimetry, x-ray crystallography | association, direct interaction, physical, physical association | 11053437, 11983899, 12234920, 12593795, 12593796, 12815057, 15004239, 15962011, 16246327, 16479008, 16893902, 17255109, 17974561, 18273061, 20124286, 20461437, 20877636, 21596750, (Europe PMC) | 0.86 | BioGRID, IntAct, MINT |
| CHRD | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| CHRNG | two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid | physical association | 25910212, (Europe PMC) | 0.56 | IntAct |
| CREB5 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| CRIP2 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| CRMP1 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| CSTB | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| CTH | Affinity Capture-MS | physical | 28514442, (Europe PMC) | NA | BioGRID |
| CTNNA3 | Affinity Capture-MS | physical | 23718855, (Europe PMC) | NA | BioGRID |
| CTSB | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| DGCR6 | Two-hybrid | physical | 24722188, (Europe PMC) | NA | BioGRID |
| DNM2 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| EBI-10171679 | two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical association | 25416956, (Europe PMC) | 0.56 | IntAct |
| EBI-10173330 | two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical association | 25416956, (Europe PMC) | 0.56 | IntAct |
| EBI-16428938 | two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical association | 26871637, (Europe PMC) | 0.56 | IntAct |
| EGLN1 | Affinity Capture-Western | physical | 22006925, (Europe PMC) | NA | BioGRID |
| EGLN2 | Affinity Capture-Western | physical | 22006925, (Europe PMC) | NA | BioGRID |
| EGLN3 | Affinity Capture-Western | physical | 22006925, (Europe PMC) | NA | BioGRID |
| EIF4E2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| ELAVL1 | Affinity Capture-RNA | physical | 19322201, (Europe PMC) | NA | BioGRID |
| FAIM | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| FAM219A | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| FBN1 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| FRS2 | Affinity Capture-Western | physical | 15004239, (Europe PMC) | NA | BioGRID |
| FRS3 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| GNE | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| GP9 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| GPRIN2 | Two-hybrid, two hybrid pooling approach | physical, physical association | 16189514, (Europe PMC) | 0.37 | BioGRID, IntAct |
| GRAP2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| GRB2 | Affinity Capture-Western, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, filter binding | association, direct interaction, physical, physical association | 10940627, 15004239, 16893902, 17255109, 17974561, (Europe PMC) | 0.59 | BioGRID, IntAct, MINT |
| GRN | two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid | physical association | 25910212, (Europe PMC) | 0.56 | IntAct |
| HEXIM2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| HGS | Affinity Capture-Western | physical | 17320394, (Europe PMC) | NA | BioGRID |
| HIF1A | Affinity Capture-Western, Co-localization | physical | 27281823, (Europe PMC) | NA | BioGRID |
| HRAS | Affinity Capture-Western | physical | 18048363, (Europe PMC) | NA | BioGRID |
| HSD3B7 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 21516116, 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| ITSN1 | Two-hybrid | physical | 22558309, (Europe PMC) | NA | BioGRID |
| KDM1A | Two-hybrid, two hybrid | physical, physical association | 23455924, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| KIF1A | Two-hybrid | physical | 24722188, (Europe PMC) | NA | BioGRID |
| KRTAP10-1 | Two-hybrid | physical | 25416956, (Europe PMC) | NA | BioGRID |
| KRTAP10-11 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP10-3 | Two-hybrid | physical | 25416956, (Europe PMC) | NA | BioGRID |
| KRTAP10-5 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP10-8 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP10-9 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP4-11 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP4-12 | Two-hybrid, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 16189514, 25416956, (Europe PMC) | 0.67 | BioGRID, IntAct |
| KRTAP4-7 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP5-6 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP5-9 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP9-2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| KRTAP9-4 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LASP1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LCE1B | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LCE2D | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LCE3C | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LCE3E | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LCE4A | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| LONRF1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| MAPKBP1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| MDFI | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| MEOX2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| MID2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| MKNK1 | Affinity Capture-Western, Biochemical Activity | physical | 16479008, (Europe PMC) | NA | BioGRID |
| MLLT6 | Two-hybrid | physical | 25416956, (Europe PMC) | NA | BioGRID |
| NCK2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| NEDD4 | Affinity Capture-Western, Reconstituted Complex | physical | 19864419, (Europe PMC) | NA | BioGRID |
| NR1H2 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| NUBP1 | Two-hybrid | physical | 21900206, (Europe PMC) | NA | BioGRID |
| NUBP1 | two hybrid | physical association | 21900206, (Europe PMC) | 0.37 | IntAct, MINT |
| OTX1 | Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 21516116, 25416956, (Europe PMC) | 0.67 | BioGRID, IntAct, MINT |
| PACSIN3 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| PLS1 | Affinity Capture-MS | physical | 26186194, 28514442, (Europe PMC) | NA | BioGRID |
| PLSCR1 | Two-hybrid, two hybrid pooling approach | physical, physical association | 16189514, (Europe PMC) | 0.37 | BioGRID, IntAct |
| PPP2CA | Affinity Capture-Western | physical | 17255109, 17974561, (Europe PMC) | NA | BioGRID |
| PPP2R1A | Affinity Capture-Western | physical | 17255109, (Europe PMC) | NA | BioGRID |
| PRKAB2 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 24722188, 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| PRKCD | Affinity Capture-Western, Far Western | physical | 19458088, (Europe PMC) | NA | BioGRID |
| PRKD1 | Affinity Capture-Western, Far Western | physical | 19458088, (Europe PMC) | NA | BioGRID |
| PTGER3 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| RAF1 | Affinity Capture-Western | physical | 12717443, (Europe PMC) | NA | BioGRID |
| RTF2 | Two-hybrid | physical | 21900206, (Europe PMC) | NA | BioGRID |
| RTFDC1 | two hybrid | physical association | 21900206, (Europe PMC) | 0.37 | IntAct, MINT |
| RUNX1T1 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| RYDEN | two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical association | 25416956, (Europe PMC) | 0.56 | IntAct |
| S100A13 | Affinity Capture-MS | physical | 28514442, (Europe PMC) | NA | BioGRID |
| SDHB | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| SEMA5B | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| SH3KBP1 | Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation | association, physical, physical association | 15962011, 25416956, (Europe PMC) | 0.50 | BioGRID, IntAct, MINT |
| SIAH2 | Reconstituted Complex | physical | 16888801, (Europe PMC) | NA | BioGRID |
| SNX3 | Affinity Capture-MS | physical | 26186194, 28514442, (Europe PMC) | NA | BioGRID |
| SPRY1 | Affinity Capture-Western, Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 15004239, 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| SPRY2 | Two-hybrid, two hybrid array | physical, physical association | 25416956, (Europe PMC) | 0.37 | BioGRID, IntAct |
| SPRY4 | Affinity Capture-Western | physical | 15004239, (Europe PMC) | NA | BioGRID |
| STK16 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| TCAF1 | Two-hybrid | physical | 25416956, (Europe PMC) | NA | BioGRID |
| TCAF1 | two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical association | 25416956, (Europe PMC) | 0.56 | IntAct |
| TES | Affinity Capture-MS | physical | 28514442, (Europe PMC) | NA | BioGRID |
| TESK1 | Affinity Capture-Western | physical | 17974561, (Europe PMC) | NA | BioGRID |
| TMEM14B | Two-hybrid | physical | 21516116, (Europe PMC) | NA | BioGRID |
| TNS2 | Two-hybrid, two hybrid array | physical, physical association | 25814554, (Europe PMC) | 0.37 | BioGRID, IntAct |
| TRAF2 | Two-hybrid, two hybrid pooling approach | physical, physical association | 16189514, (Europe PMC) | 0.37 | BioGRID, IntAct |
| TRIM51 | Two-hybrid, two hybrid pooling approach | physical, physical association | 16189514, (Europe PMC) | 0.37 | BioGRID, IntAct |
| TXNDC5 | Two-hybrid | physical | 25416956, (Europe PMC) | NA | BioGRID |
| UBASH3A | Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 21516116, 25416956, (Europe PMC) | 0.67 | BioGRID, IntAct, MINT |
| UBASH3B | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| UBE2D2 | Affinity Capture-MS | physical | 26186194, 28514442, (Europe PMC) | NA | BioGRID |
| UBE2E3 | Affinity Capture-MS | physical | 26186194, (Europe PMC) | NA | BioGRID |
| UBR1 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| USP20 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| VANGL1 | Affinity Capture-MS | physical | 26186194, (Europe PMC) | NA | BioGRID |
| VANGL2 | Affinity Capture-MS | physical | 26186194, (Europe PMC) | NA | BioGRID |
| VHL | Affinity Capture-Western | physical | 22006925, (Europe PMC) | NA | BioGRID |
| VPS25 | Affinity Capture-Western, Two-hybrid | physical | 21543492, (Europe PMC) | NA | BioGRID |
| VPS36 | Two-hybrid | physical | 21543492, (Europe PMC) | NA | BioGRID |
| ZBTB16 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| ZDHHC17 | Affinity Capture-MS, Affinity Capture-Western, Two-hybrid | physical | 24705354, 25416956, 26186194, 28514442, (Europe PMC) | NA | BioGRID |
| ZDHHC17 | two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical association | 25416956, (Europe PMC) | 0.56 | IntAct |
| ZFP36 | Affinity Capture-RNA | physical | 21784977, (Europe PMC) | NA | BioGRID |
| ZNF266 | Two-hybrid, two hybrid | physical, physical association | 21900206, (Europe PMC) | 0.37 | BioGRID, IntAct, MINT |
| ZNF417 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| ZNF587 | Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid | physical, physical association | 25416956, (Europe PMC) | 0.56 | BioGRID, IntAct |
| Phosphorylating Kinases | Phosphoresidues | Detection Method | PubMed IDs | Source |
| DYRK1A | T75_KPAPRPStQHKHERL, | LTP | 18678649,(Europe PMC) | PhosphoELM, PhosphoSitePlus, |
| MKNK1 | S112_APLSRSIsTVSSGSR, S121_VSSGSRSsTRTSTSS, | NA | NA | PhosphoSitePlus, |
| MKNK2 | S112_APLSRSIsTVSSGSR, S121_VSSGSRSsTRTSTSS, | NA | NA | PhosphoSitePlus, |
| SRC | Y55_AIRNTNEyTEGPTVV, | LTP | 15564375,(Europe PMC) | PhosphoELM, PhosphoSitePlus, |
| Unknown | S139_EQRLLGSsFSSGPVA, Y227_CCVKGLFyHCSNDDE, Y55_AIRNTNEyTEGPTVV, | LTP, in vivo | 12593795, 12815057, 15637081, 16000370, 18578522,(Europe PMC) | HPRD, PhosphoELM, |