Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
299 KEGG pathways;
876 Reactome pathways;
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023




Gene Name PTPN11 (QuickGO)
Interactive visualization PTPN11 structures
(A quick tutorial to explore the interctive visulaization)

Synonyms PTPN11, PTP2C, SHPTP2
Protein Name PTPN11
Alternative Name(s)
Tyrosine-protein phosphatase non-receptor type 11;;Protein-tyrosine phosphatase 1D;PTP-1D;Protein-tyrosine phosphatase 2C;PTP-2C;SH-PTP2;SHP-2;Shp2;SH-PTP3;
EntrezGene ID5781   (Comparitive Toxicogenomics)
UniProt AC (Human) Q06124 (protein sequence)
Enzyme ClassEC (BRENDA )
Molecular Weight68436 Dalton
Protein Length597 amino acids (AA)
Genome Browsers NCBI | ENSG00000179295 (Ensembl) | UCSC
Crosslinking annotations Query our ID-mapping table
Orthologues Quest For Orthologues (QFO) | GeneTree
Classification Superfamily: Class I Cys-based PTPs --> Family: NR-PTP | Historic class: Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CATH ID: | SCOP Fold: CC1
Phosphatase activityactive | Catalytic signature motif: unknown
Phosphorylation Network Visualize
Domain organization, Expression, Diseases(show / hide)
Localization, Function, Catalytic activity and Sequence(show / hide)
Motif information from Eukaryotic Linear Motif atlas (ELM)(show / hide)
Gene Ontology (P: Process; F: Function and C: Component terms)(show / hide)