DEPOD - human DEPhOsphorylation Database

Basic Information
Phosphatases
Pathway
Interacting Proteins
Phosphorylating Kinases

Gene Name	EGFR (QuickGO)	Interactive visualization of EGFR structures (A quick tutorial to explore the interctive visulaization) Representative structure: 4R5S
Synonyms	EGFR, ERBB, ERBB1, HER1
Protein Name	EGFR
Alternative Name(s)	Epidermal growth factor receptor;2.7.10.1;Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1;
Protein Family	Belongs to the protein kinase superfamily Tyr proteinkinase family EGF receptor subfamily
EntrezGene ID	1956 (Comparitive Toxicogenomics)
UniProt AC (Human)	P00533 (protein sequence)
Enzyme Class	2.7.10.1 (BRENDA )
Molecular Weight	134277 Dalton
Protein Length	1210 amino acids (AA)
Genome Browsers	NCBI \| ENSG00000146648 (Ensembl) \| UCSC
Crosslinking annotations	Query our ID-mapping table
Orthologues	Quest For Orthologues (QFO) \| GeneTree \| eggNOG - KOG1025 \| eggNOG - ENOG410XNSR
Phosphorylation Network	Visualize

Domain organization, Expression, Diseases

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Localization, Function, Catalytic activity and Sequence

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Localization (UniProt annotation)
Cell membrane Endoplasmic reticulum membrane ;Single-pass type I membrane protein Golgi apparatus membrane;Single-pass type I membrane protein Nucleus membrane; Single-passtype I membrane protein Endosome Endosome membrane Nucleus Note=In response to EGF,translocated from the cell membrane to the nucleus via Golgi andER (PubMed:20674546) Endocytosed upon activation by ligand(PubMed:2790960, PubMed:17182860, PubMed:27153536) Colocalizedwith GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055) Isoform 2: Secreted
Function (UniProt annotation)
Receptor tyrosine kinase binding ligands of the EGFfamily and activating several signaling cascades to convertextracellular cues into appropriate cellular responses(PubMed:2790960, PubMed:10805725, PubMed:27153536) Known ligandsinclude EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin,epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960,PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079,PubMed:12297049, PubMed:27153536, PubMed:20837704) Ligand bindingtriggers receptor homo- and/or heterodimerization andautophosphorylation on key cytoplasmic residues Thephosphorylated receptor recruits adapter proteins like GRB2 whichin turn activates complex downstream signaling cascades Activatesat least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules(PubMed:27153536) May also activate the NF-kappa-B signalingcascade (PubMed:11116146) Also directly phosphorylates otherproteins like RGS16, activating its GTPase activity and probablycoupling the EGF receptor signaling to the G protein-coupledreceptor signaling (PubMed:11602604) Also phosphorylates MUC1 andincreases its interaction with SRC and CTNNB1/beta-catenin(PubMed:11483589) Plays a role in enhancing learning and memoryperformance (By similarity) Isoform 2 may act as an antagonist of EGF action (Microbial infection) Acts as a receptor for hepatitis Cvirus (HCV) in hepatocytes and facilitates its cell entryMediates HCV entry by promoting the formation of the CD81-CLDN1receptor complexes that are essential for HCV entry and byenhancing membrane fusion of cells expressing HCV envelopeglycoproteins
Catalytic Activity (UniProt annotation)
ATP + a [protein]-L-tyrosine = ADP + a[protein]-L-tyrosine phosphate
Protein Sequence
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLK TIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVE SIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEE DGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKE ITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHP ECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNG PKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLD YVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW MALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSSLSA TSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPS RDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV APQSSEFIGA

Motif information from Eukaryotic Linear Motif atlas (ELM)

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Gene Ontology (P: Process; F: Function and C: Component terms)

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GO:0000139	C:Golgi membrane
GO:0000165	P:MAPK cascade
GO:0001503	P:ossification
GO:0001618	F:virus receptor activity
GO:0001892	P:embryonic placenta development
GO:0001934	P:positive regulation of protein phosphorylation
GO:0001942	P:hair follicle development
GO:0003682	F:chromatin binding
GO:0003690	F:double-stranded DNA binding
GO:0004709	F:MAP kinase kinase kinase activity
GO:0004713	F:protein tyrosine kinase activity
GO:0004714	F:transmembrane receptor protein tyrosine kinase activity
GO:0004888	F:transmembrane signaling receptor activity
GO:0005006	F:epidermal growth factor-activated receptor activity
GO:0005088	F:Ras guanyl-nucleotide exchange factor activity
GO:0005178	F:integrin binding
GO:0005516	F:calmodulin binding
GO:0005524	F:ATP binding
GO:0005615	C:extracellular space
GO:0005634	C:nucleus
GO:0005737	C:cytoplasm
GO:0005768	C:endosome
GO:0005789	C:endoplasmic reticulum membrane
GO:0005886	C:plasma membrane
GO:0005925	C:focal adhesion
GO:0006357	P:regulation of transcription by RNA polymerase II
GO:0006412	P:translation
GO:0006970	P:response to osmotic stress
GO:0007165	P:signal transduction
GO:0007166	P:cell surface receptor signaling pathway
GO:0007173	P:epidermal growth factor receptor signaling pathway
GO:0007202	P:activation of phospholipase C activity
GO:0007435	P:salivary gland morphogenesis
GO:0007494	P:midgut development
GO:0007611	P:learning or memory
GO:0007623	P:circadian rhythm
GO:0008283	P:cell proliferation
GO:0008284	P:positive regulation of cell proliferation
GO:0009986	C:cell surface
GO:0010008	C:endosome membrane
GO:0010750	P:positive regulation of nitric oxide mediated signal transduction
GO:0010960	P:magnesium ion homeostasis
GO:0014066	P:regulation of phosphatidylinositol 3-kinase signaling
GO:0016020	C:membrane
GO:0016021	C:integral component of membrane
GO:0016101	P:diterpenoid metabolic process
GO:0016323	C:basolateral plasma membrane
GO:0016324	C:apical plasma membrane
GO:0018108	P:peptidyl-tyrosine phosphorylation
GO:0019899	F:enzyme binding
GO:0019901	F:protein kinase binding
GO:0019903	F:protein phosphatase binding
GO:0021795	P:cerebral cortex cell migration
GO:0030139	C:endocytic vesicle
GO:0030307	P:positive regulation of cell growth
GO:0030324	P:lung development
GO:0030335	P:positive regulation of cell migration
GO:0030665	C:clathrin-coated vesicle membrane
GO:0031625	F:ubiquitin protein ligase binding
GO:0031659	P:positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0031901	C:early endosome membrane
GO:0031965	C:nuclear membrane
GO:0032930	P:positive regulation of superoxide anion generation
GO:0032991	C:protein-containing complex
GO:0033138	P:positive regulation of peptidyl-serine phosphorylation
GO:0033590	P:response to cobalamin
GO:0033594	P:response to hydroxyisoflavone
GO:0034614	P:cellular response to reactive oxygen species
GO:0038083	P:peptidyl-tyrosine autophosphorylation
GO:0038128	P:ERBB2 signaling pathway
GO:0042059	P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0042060	P:wound healing
GO:0042177	P:negative regulation of protein catabolic process
GO:0042327	P:positive regulation of phosphorylation
GO:0042698	P:ovulation cycle
GO:0042743	P:hydrogen peroxide metabolic process
GO:0042802	F:identical protein binding
GO:0043006	P:activation of phospholipase A2 activity by calcium-mediated signaling
GO:0043066	P:negative regulation of apoptotic process
GO:0043235	C:receptor complex
GO:0043406	P:positive regulation of MAP kinase activity
GO:0043586	P:tongue development
GO:0045121	C:membrane raft
GO:0045202	C:synapse
GO:0045296	F:cadherin binding
GO:0045739	P:positive regulation of DNA repair
GO:0045740	P:positive regulation of DNA replication
GO:0045746	P:negative regulation of Notch signaling pathway
GO:0045780	P:positive regulation of bone resorption
GO:0045893	P:positive regulation of transcription
GO:0045907	DNA-templated
GO:0045930	P:positive regulation of vasoconstriction
GO:0045944	P:negative regulation of mitotic cell cycle
GO:0046328	P:positive regulation of transcription by RNA polymerase II
GO:0046777	P:regulation of JNK cascade
GO:0046934	P:protein autophosphorylation
GO:0046982	F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048143	F:protein heterodimerization activity
GO:0048146	P:astrocyte activation
GO:0048408	P:positive regulation of fibroblast proliferation
GO:0048471	F:epidermal growth factor binding
GO:0048546	C:perinuclear region of cytoplasm
GO:0048661	P:digestive tract morphogenesis
GO:0048812	P:positive regulation of smooth muscle cell proliferation
GO:0050679	P:neuron projection morphogenesis
GO:0050729	P:positive regulation of epithelial cell proliferation
GO:0050730	P:positive regulation of inflammatory response
GO:0050999	P:regulation of peptidyl-tyrosine phosphorylation
GO:0051015	P:regulation of nitric-oxide synthase activity
GO:0051205	F:actin filament binding
GO:0051592	P:protein insertion into membrane
GO:0051897	P:response to calcium ion
GO:0051968	P:positive regulation of protein kinase B signaling
GO:0060571	P:positive regulation of synaptic transmission
GO:0061024	glutamatergic
GO:0061029	P:morphogenesis of an epithelial fold
GO:0070141	P:membrane organization
GO:0070372	P:eyelid development in camera-type eye
GO:0070374	P:response to UV-A
GO:0070435	P:regulation of ERK1 and ERK2 cascade
GO:0071230	P:positive regulation of ERK1 and ERK2 cascade
GO:0071260	C:Shc-EGFR complex
GO:0071276	P:cellular response to amino acid stimulus
GO:0071364	P:cellular response to mechanical stimulus
GO:0071392	P:cellular response to cadmium ion
GO:0071549	P:cellular response to epidermal growth factor stimulus
GO:0090263	P:cellular response to estradiol stimulus
GO:0097421	P:cellular response to dexamethasone stimulus
GO:0097489	P:positive regulation of canonical Wnt signaling pathway
GO:0097755	P:liver regeneration
GO:0098609	C:multivesicular body
GO:1900020	internal vesicle lumen
GO:1901185	P:positive regulation of blood vessel diameter
GO:1901224	P:cell-cell adhesion
GO:1902722	P:positive regulation of protein kinase C activity
GO:1903078	P:negative regulation of ERBB signaling pathway
GO:1903800	P:positive regulation of NIK/NF-kappaB signaling
GO:1905208	P:positive regulation of prolactin secretion
GO:2000145	P:positive regulation of protein localization to plasma membrane

KEGG Pathway
Reactome Pathway

Pathway ID	Pathway Name	Pathway Description (KEGG)
hsa01521	EGFR tyrosine kinase inhibitor resistance	EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which activate down- stream pathways, are associated with cancers, especially lung cancer. Several tyrosine kinase inhibitor (TKI) therapies against EGFR are currently administered and are initially effective in cancer patients who have EGFR mutations or aberrant activation of EGFR. However, the development of TKI resistance is common and results in the recurrence of tumors. Studies over the last decade have identified mechanisms that drive resistance to EGFR TKI treatment. Most outstanding mechanisms are: the secondary EGFR mutation (T790M), activation of alternative pathways (c-Met, HGF, AXL), aberrance of the downstream pathways (K-RAS mutations, loss of PTEN), impairment of the EGFR-TKIs-mediated apoptosis pathway (BCL2-like 11/BIM deletion polymorphism), histologic transformation, etc.
hsa01522	Endocrine resistance	Endocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SERMs, e.g. tamoxifen), estrogen synthesis inhibitors (e.g. aromatase inhibitors (AIs) such as anastrozole, letrozole, and exemestane), and selective estrogen receptor down-regulators (SERDs, e.g. fulvestrant). However, resistance to these agents has become a major clinical obstacle. Mechanisms of endocrine resistance include loss of ER-alpha expression, altered expression of coactivators or coregulators that play a critical role in ER-mediated gene transcription, ligand-independent growth factor signaling cascades that activate kinases and ER-phosphorylation, altered availability of active tamoxifen metabolites regulated by drug-metabolizing enzymes, such as CYP2D6, and deregulation of the cell cycle and apoptotic machinery.
hsa04010	MAPK signaling pathway	The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
hsa04012	ErbB signaling pathway	The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. Signaling effectors containing binding pockets for pY-containing peptides are recruited to activated receptors and induce the various signaling pathways. The Shc- and/or Grb2-activated mitogen-activated protein kinase (MAPK) pathway is a common target downstream of all ErbB receptors. Similarly, the phosphatidylinositol-3-kinase (PI-3K) pathway is directly or indirectly activated by most ErbBs. Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kinase Src, or the Cbl E3 ubiquitin protein ligase.
hsa04014	Ras signaling pathway	The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
hsa04015	Rap1 signaling pathway	Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
hsa04020	Calcium signaling pathway	Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
hsa04066	HIF-1 signaling pathway	Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a constitutively-expressed HIF-1beta subunit. Under normoxia, HIF-1 alpha undergoes hydroxylation at specific prolyl residues which leads to an immediate ubiquitination and subsequent proteasomal degradation of the subunit. In contrast, under hypoxia, HIF-1 alpha subunit becomes stable and interacts with coactivators such as p300/CBP to modulate its transcriptional activity. Eventually, HIF-1 acts as a master regulator of numerous hypoxia-inducible genes under hypoxic conditions. The target genes of HIF-1 encode proteins that increase O2 delivery and mediate adaptive responses to O2 deprivation. Despite its name, HIF-1 is induced not only in response to reduced oxygen availability but also by other stimulants, such as nitric oxide, or various growth factors.
hsa04068	FoxO signaling pathway	The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
hsa04072	Phospholipase D signaling pathway	Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively.
hsa04144	Endocytosis	Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
hsa04151	PI3K-Akt signaling pathway	The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
hsa04510	Focal adhesion	Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
hsa04520	Adherens junction	Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
hsa04540	Gap junction	Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
hsa04630	Jak-STAT signaling pathway	The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
hsa04810	Regulation of actin cytoskeleton
hsa04912	GnRH signaling pathway	Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
hsa04915	Estrogen signaling pathway	Estrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. Estrogen mediates its cellular actions through two signaling pathways classified as nuclear-initiated steroid signalingand membrane-initiated steroid signaling. In the nuclearpathway, estrogen binds either ERalpha or ERbeta, which in turn translocates to the nucleus, binds DNA at ERE elements and activates the expression of ERE-dependent genes. In membranepathway, Estrogen can exert its actions through a subpopulation of ER at the plasma membrane (mER) or novel G-protein coupled E2 receptors (GPER). Upon activation of these receptors various signaling pathways (i.e. Ca2+, cAMP, protein kinase cascades) are rapidly activated and ultimately influence downstream transcription factors.
hsa04921	Oxytocin signaling pathway	Oxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and peripheral effects. However, its best-known and most well-established roles are stimulation of uterine contractions during parturition and milk release during lactation. Oxytocin also influences cardiovascular regulation and various social behaviors. The actions of OT are all mediated by one type of OT receptor (OTR). This is a transmembrane receptor belonging to the G-protein-coupled receptor superfamily. The main signaling pathway is the Gq/PLC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. In the cardiovascular system, OTR is associated with the ANP-cGMP and NO-cGMP pathways, which reduce the force and rate of contraction and increase vasodilatation.
hsa04926	Relaxin signaling pathway	Human relaxin-2 (relaxin), originally identified as a peptidic hormone of pregnancy, is now known to exert a range of pleiotropic effects including vasodilatory, anti-fibrotic and angiogenic effects in both males and females. It belongs to the so-called relaxin peptide family which includes the insulin-like peptides INSL3 and INSL5, and relaxin-3 (H3) as well as relaxin. INSL3 has clearly defined specialist roles in male and female reproduction, relaxin-3 is primarily a neuropeptide involved in stress and metabolic control, and INSL5 is widely distributed particularly in the gastrointestinal tract. These members of relaxin peptide family exert such effects binding to different kinds of receptors, classified as relaxin family peptide (RXFP) receptors: RXFP1, RXFP2, RXFP3, and RXFP4. These G protein-coupled receptors predominantly bind relaxin, INSL3, relaxin-3, and INSL-5, respectively. RXFP1 activates a wide spectrum of signaling pathways to generate second messengers that include cAMP and nitric oxide, whereas RXFP2 activates a subset of these pathways. Both RXFP3 and RXFP4 inhibit cAMP production, and RXFP3 activate MAP kinases.
hsa04928	Parathyroid hormone synthesis, secretion and action	Parathyroid hormone (PTH) is a key regulator of calcium and phosphorus homeostasis. The principal regulators of PTH secretion are extracellular ionized calcium (Ca2+) and 1,25-dihydroxyvitamin D (1,25(OH)2D3). Under conditions of dietary Ca restriction, a decrement in serum Ca concentration induces release of PTH from the parathyroid gland. PTH acts on bone and kidney to stimulate bone turnover, increase the circulating levels of 1,25(OH)2D3 and calcium and inhibit the reabsorption of phosphate from the glomerular filtrate. This hormone exerts its actions via binding to the PTH/PTH-related peptide receptor (PTH1R). PTH1R primarily activates two sub-types of heterotrimeric Gproteins: Gs and Gq , which in turn regulate the activity of adenylyl cyclases and phospholipase C (PLC) that control the flow of cAMP/PKA and IP/PKC signaling cascades, respectively.
hsa04934	Cushing syndrome	Cushing syndrome (CS) is a rare disorder resulting from prolonged exposure to excess glucocorticoids via exogenous and endogenous sources. The typical clinical features of CS are related to hypercortisolism and include accumulation of central fat, moon facies, neuromuscular weakness, osteoporosis or bone fractures, metabolic complications, and mood changes. Traditionally, endogenous CS is classified as adrenocorticotropic hormone (ACTH)-dependent (about 80%) or ACTH- independent (about 20%). Among ACTH-dependent forms, pituitary corticotroph adenoma (Cushing's disease) is most common. Most pituitary tumors are sporadic, resulting from monoclonal expansion of a single mutated cell. Recently recurrent activating somatic driver mutations in the ubiquitin-specific protease 8 gene (USP8) were identified in almost half of corticotroph adenoma. Germline mutations in MEN1 (encoding menin), AIP (encoding aryl-hydrocarbon receptor-interacting protein), PRKAR1A (encoding cAMP-dependent protein kinase type I alpha regulatory subunit) and CDKN1B (encoding cyclin-dependent kinase inhibitor 1B; also known as p27 Kip1) have been identified in familial forms of pituitary adenomas. However, the frequency of familial pituitary adenomas is less than 5% in patients with pituitary adenomas. Among ACTH-independent CS, adrenal adenoma is most common. Rare adrenal causes of CS include primary bilateral macronodular adrenal hyperplasia (BMAH) or primary pigmented nodular adrenocortical disease (PPNAD).
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	Two major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA).VacA binds to lipid rafts and glycosylphosphatidylinositol-anchored proteins (GPI-APs) of the target cell membrane. After insertion into the plasma membrane, VacA channels are endocytosed and eventually reach late endosomal compartments, increasing their permeability to anions with enhancement of the electrogenic vacuolar ATPase (v-ATPase) proton pump. In the presence of weak bases, osmotically active acidotropic ions will accumulate in the endosomes. This leads to water influx and vesicle swelling, an essential step in vacuole formation. In addition, it is reported that the VacA cleavage product binds to the tyrosine phosphatase receptor zeta (Ptprz) on epithelial cells and the induced signaling leads to the phosphorylation of the G protein-coupled receptor kinase-interactor 1 (Git1) and induces ulcerogenesis in mice.The other virulence factor cag T4SS mediates the translocation of the effector protein CagA, which is subsequently phosphorylated by a Src kinase. Phosphorylated CagA interacts with the protein tyrosine phosphatase SHP-2, thus stimulating its phosphatase activity. Activated SHP-2 is able to induce MAPK signalling through Ras/Raf-dependent and -independent mechanisms. Deregulation of this pathway by CagA may lead to abnormal proliferation and movement of gastric epithelial cells.
hsa05160	Hepatitis C	Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
hsa05163	Human cytomegalovirus infection	Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
hsa05165	Human papillomavirus infection	Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
hsa05200	Pathways in cancer
hsa05205	Proteoglycans in cancer	Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR: 00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
hsa05206	MicroRNAs in cancer	MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
hsa05210	Colorectal cancer	Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined oncogenes and tumour suppressor genes (TSG). Two major mechanisms of genomic instability have been identified in sporadic CRC progression. The first, known as chromosomal instability (CIN), results from a series of genetic changes that involve the activation of oncogenes such as K-ras and inactivation of TSG such as p53, DCC/Smad4, and APC. The second, known as microsatellite instability (MSI), results from inactivation of the DNA mismatch repair genes MLH1 and/or MSH2 by hypermethylation of their promoter, and secondary mutation of genes with coding microsatellites, such as transforming growth factor receptor II (TGF-RII) and BAX. Hereditary syndromes have germline mutations in specific genes (mutation in the tumour suppressor gene APC on chromosome 5q in FAP, mutated DNA mismatch repair genes in HNPCC).
hsa05212	Pancreatic cancer	Infiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA). Normal duct epithelium progresses to infiltrating cancer through a series of histologically defined precursors (PanINs). The overexpression of HER-2/neu and activating point mutations in the K-ras gene occur early, inactivation of the p16 gene at an intermediate stage, and the inactivation of p53, SMAD4, and BRCA2 occur relatively late. Activated K-ras engages multiple effector pathways. Although EGF receptors are conventionally regarded as upstream activators of RAS proteins, they can also act as RAS signal transducers via RAS-induced autocrine activation of the EGFR family ligands. Moreover, PDA shows extensive genomic instability and aneuploidy. Telomere attrition and mutations in p53 and BRCA2 are likely to contribute to these phenotypes. Inactivation of the SMAD4 tumour suppressor gene leads to loss of the inhibitory influence of the transforming growth factor-beta signalling pathway.
hsa05213	Endometrial cancer	Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
hsa05214	Glioma	Gliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (astrocytomas), oligodendrocytes (oligodendrogliomas), mixtures of various glial cells (for example,oligoastrocytomas) and ependymal cells (ependymomas). The most malignant form of infiltrating astrocytoma - glioblastoma multiforme (GBM) - is one of the most aggressive human cancers. GBM may develop de novo (primary glioblastoma) or by progression from low-grade or anaplastic astrocytoma (secondary glioblastoma). Primary glioblastomas develop in older patients and typically show genetic alterations (EGFR amplification, p16/INK4a deletion, and PTEN mutations) at frequencies of 24-34%. Secondary glioblastomas develop in younger patients and frequently show overexpression of PDGF and CDK4 as well as p53 mutations (65%) and loss of Rb playing major roles in such transformations. Loss of PTEN has been implicated in both pathways, although it is much more common in the pathogenesis of primary GBM.
hsa05215	Prostate cancer	Prostate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. Androgen receptor (AR) is a transcription factor that is normally activated by its androgen ligand. During androgen withdrawal therapy, the AR signal transduction pathway also could be activated by amplification of the AR gene, by AR gene mutations, or by altered activity of AR coactivators. Through these mechanisms, tumor cells lead to the emergence of androgen-independent prostate cancer.
hsa05218	Melanoma	Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes. The only known environmental risk factor is exposure to ultraviolet (UV) light and in people with fair skin the risk is greatly increased. Melanoma pathogenesis is also driven by genetic factors. Oncogenic NRAS mutations activate both effector pathways Raf-MEK-ERK and PI3K-Akt. The Raf-MEK-ERK pathway may also be activated via mutations in the BRAF gene. The PI3K-Akt pathway may be activated through loss or mutation of the inhibitory tumor suppressor gene PTEN. These mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Melanoma development has been shown to be strongly associated with inactivation of the p16INK4a/cyclin dependent kinases 4 and 6/retinoblastoma protein (p16INK4a/CDK4,6/pRb) and p14ARF/human double minute 2/p53 (p14ARF/HMD2/p53) tumor suppressor pathways. MITF and TP53 are implicated in further melanoma progression.
hsa05219	Bladder cancer	The urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carcinoma are bladder carcinomas, and urothelial carcinomas of the renal pelvis and ureter account for only approximately 7% of the total. Urothelial tumours arise and evolve through divergent phenotypic pathways. Some tumours progress from urothelial hyperplasia to low-grade non-invasive superficial papillary tumours. More aggressive variants arise either from flat, high-grade carcinoma in situ (CIS) and progress to invasive tumours, or they arise de novo as invasive tumours. Low-grade papillary tumors frequently show a constitutive activation of the receptor tyrosine kinase-Ras pathway, exhibiting activating mutations in the HRAS and fibroblast growth factor receptor 3 (FGFR3) genes. In contrast, CIS and invasive tumors frequently show alterations in the TP53 and RB genes and pathways. Invasion and metastases are promoted by several factors that alter the tumour microenvironment, including the aberrant expression of E-cadherins (E-cad), matrix metalloproteinases (MMPs), angiogenic factors such as vascular endothelial growth factor (VEGF).
hsa05223	Non-small cell lung cancer	Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heterogeneous group of cancers, consisting mainly of squamous cell (SCC), adeno (AC) and large-cell carcinoma. Molecular mechanisms altered in NSCLC include activation of oncogenes, such as K-RAS, EGFR and EML4-ALK, and inactivation of tumorsuppressor genes, such as p53, p16INK4a, RAR-beta, and RASSF1. Point mutations within the K-RAS gene inactivate GTPase activity and the p21-RAS protein continuously transmits growth signals to the nucleus. Mutations or overexpression of EGFR leads to a proliferative advantage. EML4-ALK fusion leads to constitutive ALK activation, which causes cell proliferation, invasion, and inhibition of apoptosis. Inactivating mutation of p53 can lead to more rapid proliferation and reduced apoptosis. The protein encoded by the p16INK4a inhibits formation of CDK-cyclin-D complexes by competitive binding of CDK4 and CDK6. Loss of p16INK4a expression is a common feature of NSCLC. RAR-beta is a nuclear receptor that bears vitamin-A-dependent transcriptional activity. RASSF1A is able to form heterodimers with Nore-1, an RAS effector.Therefore loss of RASSF1A might shift the balance of RAS activity towards a growth-promoting effect.
hsa05224	Breast cancer	Breast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gland. The molecular subtypes of breast cancer, which are based on the presence or absence of hormone receptors (estrogen and progesterone subtypes) and human epidermal growth factor receptor-2 (HER2), include: hormone receptor positive and HER2 negative (luminal A subtype), hormone receptor positive and HER2 positive (luminal B subtype), hormone receptor negative and HER2 positive (HER2 positive), and hormone receptor negative and HER2 negative (basal-like or triple-negative breast cancers (TNBCs)). Hormone receptor positive breast cancers are largely driven by the estrogen/ER pathway. In HER2 positive breast tumours, HER2 activates the PI3K/AKT and the RAS/RAF/MAPK pathways, and stimulate cell growth, survival and differentiation. In patients suffering from TNBC, the deregulation of various signalling pathways (Notch and Wnt/beta-catenin), EGFR protein have been confirmed. In the case of breast cancer only 8% of all cancers are hereditary, a phenomenon linked to genetic changes in BRCA1 or BRCA2. Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers.
hsa05225	Hepatocellular carcinoma	Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.
hsa05226	Gastric cancer	Gastric cancer (GC) is one of the world's most common cancers. According to Lauren's histological classification gastric cancer is divided into two distinct histological groups - the intestinal and diffuse types. Several genetic changes have been identified in intestinal-type GC. The intestinal metaplasia is characterized by mutations in p53 gene, reduced expression of retinoic acid receptor beta (RAR-beta) and hTERT expression. Gastric adenomas furthermore display mutations in the APC gene, reduced p27 expression and cyclin E amplification. In addition, amplification and overexpression of c-ErbB2, reduced TGF-beta receptor type I (TGFBRI) expression and complete loss of p27 expression are commonly observed in more advanced GC. The main molecular changes observed in diffuse-type GCs include loss of E-cadherin function by mutations in CDH1 and amplification of MET and FGFR2F.
hsa05230	Central carbon metabolism in cancer	Malignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamental differences in the central metabolic pathways operating in malignant tissue. He showed that cancer cells consume a large amount of glucose, maintain high rate of glycolysis and convert a majority of glucose into lactic acid even under normal oxygen concentrations (Warburg's Effects). More recently, it has been recognized that the 'Warburg effect' encompasses a similarly increased utilization of glutamine. From the intermediate molecules provided by enhanced glycolysis and glutaminolysis, cancer cells synthesize most of the macromolecules required for the duplication of their biomass and genome. These cancer-specific alterations represent a major consequence of genetic mutations and the ensuing changes of signalling pathways in cancer cells. Three transcription factors, c-MYC, HIF-1 and p53, are key regulators and coordinate regulation of cancer metabolism in different ways, and many other oncogenes and tumor suppressor genes cluster along the signaling pathways that regulate c-MYC, HIF-1 and p53.
hsa05231	Choline metabolism in cancer	Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS and PI3K-AKT pathways, and transcription factors associated with oncogenesis such as hypoxia-inducible factor 1 (HIF1) mediate overexpression and activation of choline cycle enzymes, which causes increased levels of choline-containing precursors and breakdown products of membrane phospholipids. These products of choline phospholipid metabolism, such as phosphocholine (PCho), diacylglycerol (DAG) and phosphatidic acid, may function as second messengers that are essential for the mitogenic activity of growth factors, particularly in the activation of the ras-raf-1-MAPK cascade and protein kinase C pathway.

Pathway ID	Pathway Name	Pathway Description (KEGG)
R-HSA-1227986	Signaling by ERBB2.	ERBB2, also known as HER2 or NEU, is a receptor tyrosine kinase (RTK) belonging to the EGFR family. ERBB2 possesses an extracellular domain that does not bind any known ligand, contrary to other EGFR family members, a single transmembrane domain, and an intracellular domain consisting of an active kinase and a C-tail with multiple tyrosine phosphorylation sites. Inactive ERBB2 is associated with a chaperone heat shock protein 90 (HSP90) and its co-chaperone CDC37 (Xu et al. 2001, Citri et al. 2004, Xu et al. 2005). In addition, ERBB2 is associated with ERBB2IP (also known as ERBIN or LAP2), a protein responsible for proper localization of ERBB2. In epithelial cells, ERBB2IP restricts expression of ERBB2 to basolateral plasma membrane regions (Borg et al. 2000).\nERBB2 becomes activated by forming a heterodimer with another ligand-activated EGFR family member, either EGFR, ERBB3 or ERBB4, which is accompanied by dissociation of chaperoning proteins HSP90 and CDC37 (Citri et al. 2004), as well as ERBB2IP (Borg et al. 2000) from ERBB2. ERBB2 heterodimers function to promote cell proliferation, cell survival and differentiation, depending on the cellular context. ERBB2 can also be activated by homodimerization when it is overexpressed, in cancer for example. \nIn cells expressing both ERBB2 and EGFR, EGF stimulation of EGFR leads to formation of both ERBB2:EGFR heterodimers (Wada et al. 1990, Karunagaran et al. 1996) and EGFR homodimers. Heterodimers of ERBB2 and EGFR trans-autophosphorylate on twelve tyrosine residues, six in the C-tail of EGFR and six in the C-tail of ERBB2 - Y1023, Y1139, Y1196, Y1221, Y1222 and Y1248 (Margolis et al. 1989, Hazan et al. 1990,Walton et al. 1990, Helin et al. 1991, Ricci et al. 1995, Pinkas-Kramarski 1996). Phosphorylated tyrosine residues in the C-tail of EGFR and ERBB2 serve as docking sites for downstream signaling molecules. Three key signaling pathways activated by ERBB2:EGFR heterodimers are RAF/MAP kinase cascade, PI3K-induced AKT signaling, and signaling by phospholipase C gamma (PLCG1). Downregulation of EGFR signaling is mediated by ubiquitin ligase CBL, and is shown under Signaling by EGFR.\nIn cells expressing ERBB2 and ERBB3, ERBB3 activated by neuregulin NRG1 or NRG2 binding (Tzahar et al. 1994) forms a heterodimer with ERBB2 (Pinkas-Kramarski et al. 1996, Citri et al. 2004). ERBB3 is the only EGFR family member with no kinase activity, and can only function in heterodimers, with ERBB2 being its preferred heterodimerization partner. After heterodimerization, ERBB2 phosphorylates ten tyrosine residues in the C-tail of ERBB3, Y1054, Y1197, Y1199, Y1222, Y1224, Y1260, Y1262, Y1276, Y1289 and Y1328 (Prigent et al. 1994, Pinkas-Kramarski et al. 1996, Vijapurkar et al. 2003, Li et al. 2007) that subsequently serve as docking sites for downstream signaling molecules, resulting in activation of PI3K-induced AKT signaling and RAF/MAP kinase cascade. Signaling by ERBB3 is downregulated by the action of RNF41 ubiquitin ligase, also known as NRDP1. \nIn cells expressing ERBB2 and ERBB4, ligand stimulated ERBB4 can either homodimerize or form heterodimers with ERBB2 (Li et al. 2007), resulting in trans-autophosphorylation of ERBB2 and ERBB4 on C-tail tyrosine residues that will subsequently serve as docking sites for downstream signaling molecules, leading to activation of RAF/MAP kinase cascade and, in the case of ERBB4 CYT1 isoforms, PI3K-induced AKT signaling (Hazan et al. 1990, Cohen et al. 1996, Li et al. 2007, Kaushansky et al. 2008). Signaling by ERBB4 is downregulated by the action of WWP1 and ITCH ubiquitin ligases, and is shown under Signaling by ERBB4
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.	Signaling by EGFR is frequently activated in cancer through activating mutations in the coding sequence of the EGFR gene, resulting in expression of a constitutively active mutant protein. Epidermal growth factor receptor kinase domain mutants are present in ~16% of non-small-cell lung cancers (NSCLCs), but are also found in other cancer types, such as breast cancer, colorectal cancer, ovarian cancer and thyroid cancer. EGFR kinase domain mutants harbor activating mutations in exons 18-21 which code for the kinase domain (amino acids 712-979) . Small deletions, insertions or substitutions of amino acids within the kinase domain lock EGFR in its active conformation in which the enzyme can dimerize and undergo autophosphorylation spontaneously, without ligand binding (although ligand binding ability is preserved), and activate downstream signaling pathways that promote cell survival (Greulich et al. 2005, Zhang et al. 2006, Yun et al. 2007, Red Brewer et al. 2009). Point mutations in the extracellular domain of EGFR are frequently found in glioblastoma. Similar to kinase domain mutations, point mutations in the extracellular domain result in constitutively active EGFR proteins that signal in the absence of ligands, but ligand binding ability and responsiveness are preserved (Lee et al. 2006). EGFR kinase domain mutants need to maintain association with the chaperone heat shock protein 90 (HSP90) for proper functioning (Shimamura et al. 2005, Lavictoire et al. 2003). CDC37 is a co-chaperone of HSP90 that acts as a scaffold and regulator of interaction between HSP90 and its protein kinase clients. CDC37 is frequently over-expressed in cancers involving mutant kinases and acts as an oncogene (Roe et al. 2004, reviewed by Gray Jr. et al. 2008). Over-expression of the wild-type EGFR or EGFR cancer mutants results in aberrant activation of downstream signaling cascades, namely RAS/RAF/MAP kinase signaling and PI3K/AKT signaling, and possibly signaling by PLCG1, which leads to increased cell proliferation and survival, providing selective advantage to cancer cells that harbor activating mutations in the EGFR gene (Sordella et al. 2004, Huang et al. 2007). While growth factor activated wild-type EGFR is promptly down-regulated by internalization and degradation, cancer mutants of EGFR demonstrate prolonged activation (Lynch et al. 2004). Association of HSP90 with EGFR kinase domain mutants negatively affects CBL-mediated ubiquitination, possibly through decreasing the affinity of EGFR kinase domain mutants for phosphorylated CBL, so that CBL dissociates from the complex upon phosphorylation and cannot perform ubiquitination (Yang et al. 2006, Padron et al. 2007). Various molecular therapeutics are being developed to target aberrantly activated EGFR in cancer. Non-covalent (reversible) small tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib, selectively bind kinase domain of EGFR, competitively inhibiting ATP binding and subsequent autophosphorylation of EGFR dimers. EGFR kinase domain mutants sensitive to non-covalent TKIs exhibit greater affinity for TKIs than ATP compared with the wild-type EGFR protein, and are therefore preferential targets of non-covalent TKI therapeutics (Yun et al. 2007). EGFR proteins that harbor point mutations in the extracellular domain also show sensitivity to non-covalent tyrosine kinase inhibitors (Lee et al. 2006). EGFR kinase domain mutants harboring small insertions in exon 20 or a secondary T790M mutation are resistant to reversible TKIs (Balak et al. 2006) due to increased affinity for ATP (Yun et al. 2008), and are targets of covalent (irreversible) TKIs that form a covalent bond with EGFR cysteine residue C397. However, effective concentrations of covalent TKIs also inhibit wild-type EGFR, causing severe side effects (Zhou et al. 2009). Hence, covalent TKIs have not shown much promise in clinical trials (Reviewed by Pao and Chmielecki in 2010)
R-HSA-1236394	Signaling by ERBB4.	ERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular ligand binding domain, a single transmembrane domain and a cytoplasmic domain which contains an active tyrosine kinase and a C-tail with multiple phosphorylation sites. At least three and possibly four splicing isoforms of ERBB4 exist that differ in their C-tail and/or the extracellular juxtamembrane regions: ERBB4 JM-A CYT1, ERBB4 JM-A CYT2 and ERBB4 JM-B CYT1 (the existence of ERBB4 JM-B CYT2 has not been confirmed). ERBB4 becomes activated by binding one of its seven ligands, three of which, HB-EGF, epiregulin EPR and betacellulin BTC, are EGF-like (Elenius et al. 1997, Riese et al. 1998), while four, NRG1, NRG2, NRG3 and NRG4, belong to the neuregulin family (Tzahar et al. 1994, Carraway et al. 1997, Zhang et al. 1997, Hayes et al. 2007). Upon ligand binding, ERBB4 forms homodimers (Sweeney et al. 2000) or it heterodimerizes with ERBB2 (Li et al. 2007). Dimers of ERBB4 undergo trans-autophosphorylation on tyrosine residues in the C-tail (Cohen et al. 1996, Kaushansky et al. 2008, Hazan et al. 1990, Li et al. 2007), triggering downstream signaling cascades. The pathway Signaling by ERBB4 only shows signaling by ERBB4 homodimers. Signaling by heterodimers of ERBB4 and ERBB2 is shown in the pathway Signaling by ERBB2. Ligand-stimulated ERBB4 is also able to form heterodimers with ligand-stimulated EGFR (Cohen et al. 1996) and ligand-stimulated ERBB3 (Riese et al. 1995). Dimers of ERBB4 with EGFR and dimers of ERBB4 with ERBB3 were demonstrated in mouse cell lines in which human ERBB4 and EGFR or ERBB3 were exogenously expressed. These heterodimers undergo trans-autophosphorylation, but their downstream signaling and physiological significance have not been studied. All splicing isoforms of ERBB4 possess two tyrosine residues in the C-tail that serve as docking sites for SHC1 (Kaushansky et al. 2008, Pinkas-Kramarski et al. 1996, Cohen et al. 1996). Once bound to ERBB4, SHC1 becomes phosphorylated on tyrosine residues by the tyrosine kinase activity of ERBB4, which enables it to recruit the complex of GRB2 and SOS1, resulting in the guanyl-nucleotide exchange on RAS and activation of RAF and MAP kinase cascade (Kainulainen et al. 2000). The CYT1 isoforms of ERBB4 also possess a C-tail tyrosine residue that, upon trans-autophosphorylation, serves as a docking site for the p85 alpha subunit of PI3K (Kaushansky et al. 2008, Cohen et al. 1996), leading to assembly of an active PI3K complex that converts PIP2 to PIP3 and activates AKT signaling (Kainulainen et al. 2000). Besides signaling as a transmembrane receptor, ligand activated homodimers of ERBB4 JM-A isoforms (ERBB4 JM-A CYT1 and ERBB4 JM-A CYT2) undergo proteolytic cleavage by ADAM17 (TACE) in the juxtamembrane region, resulting in shedding of the extracellular domain and formation of an 80 kDa membrane bound ERBB4 fragment known as ERBB4 m80 (Rio et al. 2000, Cheng et al. 2003). ERBB4 m80 undergoes further proteolytic cleavage, mediated by the gamma-secretase complex, which releases the soluble 80 kDa ERBB4 intracellular domain, known as ERBB4 s80 or E4ICD, into the cytosol (Ni et al. 2001). ERBB4 s80 is able to translocate to the nucleus, promote nuclear translocation of various transcription factors, and act as a transcription co-factor. ERBB4 plays and important role in the development of the nervous system. In neuronal precursors, ERBB4 s80 binds the complex of TAB and NCOR1, helps to move the complex into the nucleus, and is a co-factor of TAB:NCOR1-mediated inhibition of expression of astrocyte differentiation genes GFAP and S100B (Sardi et al. 2006). Erbb4 deficiency in somatostatin-expressing neurons of the thalamic reticular nucleus alters behaviors dependent on sensory selection (Ahrens et al. 2015). NRG1-activated ERBB4 signaling enhances AMPA receptor responses through PKC-dependent AMPA receptor exocytosis. This results in an increased excitatory input to parvalbumin-expressing inhibitory neurons in the visual cortex and regulates visual cortical plasticity (Sun et al. 2016). NRG1-activated ERBB4 signaling is involved in GABAergic activity in amygdala which mediates fear conditioning (fear memory) (Lu et al. 2014). Conditional Erbb4 deletion from fast-spiking interneurons, chandelier and basket cells, of the cerebral cortex leads to synaptic defects associated with increased locomotor activity and abnormal emotional, social and cognitive function that can be linked to some of the schizophrenia features. The level of GAD1 (GAD67) protein is reduced in the cortex of conditional Erbb4 mutants. GAD1 is a GABA synthesizing enzyme. Cortical mRNA levels of GAD67 are consistently decreased in schizophrenia (Del Pino et al. 2014). Erbb4 is expressed in the GABAergic neurons of the bed nucleus stria terminalis, a part of the extended amygdala. Inhibition of NRG1-triggered ERBB4 signaling induces anxiety-like behavior, which depends on GABAergic neurotransmission. NRG1-ERBB4 signaling stimulates presynaptic GABA release, but the exact mechanism is not known (Geng et al. 2016). NRG1 protects cortical interneurons against ischemic brain injury through ERBB4-mediated increase in GABAergic transmission (Guan et al. 2015). NRG2-activated ERBB4 can reduce the duration of GABAergic transmission by binding to GABA receptors at the postsynaptic membrane via their GABRA1 subunit and promoting endocytosis of GABA receptors (Mitchell et al. 2013). NRG1 promotes synchronization of prefrontal cortex interneurons in an ERBB4 dependent manner (Hou et al. 2014). NRG1-ERBB4 signaling protects neurons from the cell death induced by a mutant form of the amyloid precursor protein (APP) (Woo et al. 2012).In mammary cells, ERBB4 s80 recruits STAT5A transcription factor in the cytosol, shuttles it to the nucleus, and acts as the STAT5A co-factor in binding to and promoting transcription from the beta-casein (CSN2) promoter, and may be involved in the regulation of other lactation-related genes (Williams et al. 2004, Muraoka-Cook et al. 2008). ERBB4 s80 was also shown to bind activated estrogen receptor in the nucleus and act as its transcriptional co-factor in promoting transcription of some estrogen-regulated genes, such as progesterone receptor gene NR3C3 and CXCL12 i.e. SDF1 (Zhu et al. 2006). In human breast cancer cell lines, ERBB4 activation enhances anchorage-independent colony formation in soft agar but inhibits cell growth in a monolayer culture. Different ERBB4 ligands induce different gene expression changes in breast cancer cell lines. Some of the genes induced in response to ERBB4 signaling in breast cancer cell lines are RAB2, EPS15R and GATA4. It is not known if these gene are direct transcriptional targets of ERBB4 (Amin et al. 2004).ERBB4 increases activity of the transcription factor SREBF2, resulting in increased expression of SREBF2-target genes involved in cholesterol biosynthesis. The mechanism is not known and may involve facilitation of SREBF2 cleavage through ERBB4-mediated PI3K signaling (Haskins et al. 2016).The C-tail of ERBB4 possesses several WW-domain binding motifs (three in CYT1 isoform and two in CYT2 isoform), which enable interaction of ERBB4 with WW-domain containing proteins. ERBB4 s80, through WW-domain binding motifs, interacts with YAP1 transcription factor, a known proto-oncogene, and may be a co-regulator of YAP1-mediated transcription (Komuro et al. 2003, Omerovic et al. 2004). The tumor suppressor WWOX, another WW-domain containing protein, competes with YAP1 in binding to ERBB4 s80 and prevents translocation of ERBB4 s80 to the nucleus (Aqeilan et al. 2005). ERBB4 s80 is also able to translocate to the mitochondrial matrix, presumably when its nuclear translocation is inhibited. Once in the mitochondrion, the BH3 domain of ERBB4, characteristic of BCL2 family members, may enable it to act as a pro-apoptotic factor (Naresh et al. 2006). Activation of ERBB4 in breast cancer cell lines leads to JNK-dependent increase in BRCA1 mRNA level and mitotic cell cycle delay, but the exact mechanism has not been elucidated (Muraoka-Cook et al. 2006). WW-domain binding motifs in the C-tail of ERBB4 play an important role in the downregulation of ERBB4 receptor signaling, enabling the interaction of intact ERBB4, ERBB4 m80 and ERBB4 s80 with NEDD4 family of E3 ubiquitin ligases WWP1 and ITCH. The interaction of WWP1 and ITCH with intact ERBB4 is independent of receptor activation and autophosphorylation. Binding of WWP1 and ITCH ubiquitin ligases leads to ubiquitination of ERBB4 and its cleavage products, and subsequent degradation through both proteasomal and lysosomal routes (Omerovic et al. 2007, Feng et al. 2009). In addition, the s80 cleavage product of ERBB4 JM-A CYT-1 isoform is the target of NEDD4 ubiquitin ligase. NEDD4 binds ERBB4 JM-A CYT-1 s80 (ERBB4jmAcyt1s80) through its PIK3R1 interaction site and mediates ERBB4jmAcyt1s80 ubiquitination, thereby decreasing the amount of ERBB4jmAcyt1s80 that reaches the nucleus (Zeng et al. 2009)
R-HSA-1250196	SHC1 events in ERBB2 signaling.	All ERBB2 heterodimers, ERBB2:EGFR, ERBB2:ERBB3 and ERBB2:ERBB4, are able to activate RAF/MAP kinase cascade by recruiting SHC1 (Pinkas-Kramarski et al. 1996, Sepp-Lorenzino et al. 1996) to phosphorylated C-tail tyrosine residues in either EGFR (Y1148 and Y1173), ERBB2 (Y1196, Y1221, Y1222 and Y1248), ERBB3 (Y1328) or ERBB4 (Y1188 and Y1242 in JM-A CYT1 isoform, Y1178 and Y1232 in JM-B CYT1 isoform, Y1172 and Y1226 in JM-A CYT2 isoform). SHC1 recruitment is followed by phosphorylation (Segatto et al. 1993, Soler et al. 1994), and the phosphorylated SHC1 recruits GRB2:SOS1 complex (Xie et al. 1995), which leads to SOS1-mediated guanyl-nucleotide exchange on RAS (Xie et al. 1995) and downstream activation of RAF and MAP kinases
R-HSA-1251932	PLCG1 events in ERBB2 signaling.	Activation of PLCG1 signaling is observed only in the presence of ERBB2:EGFR heterodimers, with PLCG1 binding to phosphorylated tyrosine Y992 and Y1173 in the C-tail of EGFR (Chattopadhyay et al. 1999), and potentially Y1023 in the C-tail of ERBB2 (Fazioli et al. 1991, Cohen et al. 1996)
R-HSA-1257604	PIP3 activates AKT signaling.	Signaling by AKT is one of the key outcomes of receptor tyrosine kinase (RTK) activation. AKT is activated by the cellular second messenger PIP3, a phospholipid that is generated by PI3K. In ustimulated cells, PI3K class IA enzymes reside in the cytosol as inactive heterodimers composed of p85 regulatory subunit and p110 catalytic subunit. In this complex, p85 stabilizes p110 while inhibiting its catalytic activity. Upon binding of extracellular ligands to RTKs, receptors dimerize and undergo autophosphorylation. The regulatory subunit of PI3K, p85, is recruited to phosphorylated cytosolic RTK domains either directly or indirectly, through adaptor proteins, leading to a conformational change in the PI3K IA heterodimer that relieves inhibition of the p110 catalytic subunit. Activated PI3K IA phosphorylates PIP2, converting it to PIP3; this reaction is negatively regulated by PTEN phosphatase. PIP3 recruits AKT to the plasma membrane, allowing TORC2 to phosphorylate a conserved serine residue of AKT. Phosphorylation of this serine induces a conformation change in AKT, exposing a conserved threonine residue that is then phosphorylated by PDPK1 (PDK1). Phosphorylation of both the threonine and the serine residue is required to fully activate AKT. The active AKT then dissociates from PIP3 and phosphorylates a number of cytosolic and nuclear proteins that play important roles in cell survival and metabolism. For a recent review of AKT signaling, please refer to Manning and Cantley, 2007
R-HSA-177929	Signaling by EGFR.	The epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational change that unmasks the dimerization interface in the extracellular domain of EGFR, leading to receptor homo- or heterodimerization at the cell surface. Dimerization of the extracellular regions of EGFR triggers additional conformational change of the cytoplasmic EGFR regions, enabling the kinase domains of two EGFR molecules to achieve the catalytically active conformation. Ligand activated EGFR dimers trans-autophosphorylate on tyrosine residues in the cytoplasmic tail of the receptor. Phosphorylated tyrosines serve as binding sites for the recruitment of signal transducers and activators of intracellular substrates, which then stimulate intracellular signal transduction cascades that are involved in regulating cellular proliferation, differentiation, and survival. Recruitment of complexes containing GRB2 and SOS1 to phosphorylated EGFR dimers either directly, through phosphotyrosine residues that serve as GRB2 docking sites, or indirectly, through SHC1 recruitment, promotes GDP to GTP exchange on RAS, resulting in the activation of RAF/MAP kinase cascade. Binding of complexes of GRB2 and GAB1 to phosphorylated EGFR dimers leads to formation of the active PI3K complex, conversion of PIP2 into PIP3, and activation of AKT signaling. Phospholipase C-gamma1 (PLCG1) can also be recruited directly, through EGFR phosphotyrosine residues that serve as PLCG1 docking sites, which leads to PLCG1 phosphorylation by EGFR and activation of DAG and IP3 signaling. EGFR signaling is downregulated by the action of ubiquitin ligase CBL. CBL binds directly to the phosphorylated EGFR dimer through the phosphotyrosine Y1045 in the C-tail of EGFR, and after CBL is phosphorylated by EGFR, it becomes active and ubiquitinates phosphorylated EGFR dimers, targeting them for degradation. For a recent review of EGFR signaling, please refer to Avraham and Yarden, 2011
R-HSA-179812	GRB2 events in EGFR signaling.	Autophosphorylated EGFR tyrosine residues are docking sites for many downstream effectors in EGFR signaling. The adaptor protein GRB2 binds to phosphotyrosine residues in the C-tail of EGFR through its SH2 domain. GRB2 is constitutively associated with SOS, a guanine nucleotide exchange factor of RAS. GRB2 binding to phosphorylated EGFR results in the recruitment of SOS to the plasma membrane where it comes in proximity to RAS. This mechanism has been seen to be the model for RAS activation
R-HSA-180292	GAB1 signalosome.	GAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also known as PI3Kp85), which subsequently recruits PIK3 catalytic subunit PIK3CA (also known as PI3Kp110). PIK3, in complex with EGFR, GRB2 and GAB1, catalyzes phosphorylation of PIP2 and its conversion to PIP3, which leads to the activation of the AKT signaling
R-HSA-180336	SHC1 events in EGFR signaling.	GRB2 can bind EGFR directly or through another SH2-containing protein, SHC1. This association leads to RAS activation
R-HSA-182971	EGFR downregulation.	Regulation of receptor tyrosine kinase (RTK) activity is implicated in the control of almost all cellular functions. One of the best understood RTKs is epidermal growth factor receptor (EGFR). Growth factors can bind to EGFR and activate it to initiate signalling cascades within the cell. EGFRs can also be recruited to clathrin-coated pits which can be internalised into endocytic vesicles. From here, EGFRs can either be recycled back to the plasma membrane or directed to lysosomes for destruction.This provides a mechanism by which EGFR signalling is negatively regulated and controls the strength and duration of EGFR-induced signals. It also prevents EGFR hyperactivation as commonly seen in tumorigenesis.The proto-oncogene Cbl can negatively regulate EGFR signalling. The Cbl family of RING-type ubiquitin ligases are able to poly-ubiquitinate EGFR, an essential step in EGFR degradation. All Cbl proteins have a unique domain that recognises phosphorylated tyrosine residues on activated EGFRs. They also direct the ubiquitination and degradation of activated EGFRs by recruiting ubiquitin-conjugation enzymes. Cbl proteins function by specifically targeting activated EGFRs and mediating their down-regulation, thus providing a means by which signaling processes can be negatively regulated.Cbl also promotes receptor internalization via it's interaction with an adaptor protein, CIN85 (Cbl-interacting protein of 85kDa). CIN85 binds to Cbl via it's SH3 domain and is enhanced by the EGFR-induced tyrosine phosphorylation of Cbl. The proline-rich region of CIN85 interacts with endophilins which are regulatory components of clathrin-coated vesicles (CCVs). Endophilins bind to membranes and induce membrane curvature, in conjunction with other proteins involved in CCV formation. The rapid recruitment of endophilin to the activated receptor complex by CIN85 is the mechanism which controls receptor internalization
R-HSA-1963640	GRB2 events in ERBB2 signaling.	ERBB2:EGFR and ERBB2:ERBB4 can directly recruit GRB2:SOS1 complex through phosphorylated C-tail tyrosines of EGFR (Y1068 and Y1086) and ERBB2 (Y1139) that serve as docking sites for GRB2 (Xie et al. 1995, Sepp-Lorenzino et al. 1996), which, again, results in SOS1-mediated guanyl-nucleotide exchange on RAS and activation of RAF and MAP kinases (Janes et al. 1994, Sepp-Lorenzino et al. 1996)
R-HSA-1963642	PI3K events in ERBB2 signaling.	ERBB2:ERBB3 and ERBB2:ERBB4cyt1 heterodimers activate PI3K signaling by direct binding of PI3K regulatory subunit p85 (Yang et al. 2007, Cohen et al. 1996, Kaushansky et al. 2008) to phosphorylated tyrosine residues in the C-tail of ERBB3 (Y1054, Y1197, Y1222, Y1224, Y1276 and Y1289) and ERBB4 CYT1 isoforms (Y1056 in JM-A CYT1 isoform and Y1046 in JM-B CYT1 isoform). Regulatory subunit p85 subsequently recruits catalytic subunit p110 of PI3K, resulting in the formation of active PI3K, conversion of PIP2 to PIP3, and PIP3-mediated activation of AKT signaling (Junttila et al. 2009, Kainulainen et al. 2000). Heterodimers of ERBB2 and EGFR recruit PI3K indirectly, through GRB2:GAB1 complex (Jackson et al. 2004), which again leads to PIP3-mediated activation of AKT signaling
R-HSA-212718	EGFR interacts with phospholipase C-gamma.	Activated epidermal growth factor receptors (EGFR) can stimulate phosphatidylinositol (PI) turnover. Activated EGFR can activate phospholipase C-gamma1 (PLC-gamma1, i.e. PLCG1) which hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). IP3 is instrumental in the release of calcium from intracellular stores and DAG is involved in protein kinase C activation
R-HSA-2179392	EGFR Transactivation by Gastrin.	Gastrin, through the action of diacylglycerol produced from downstream G alpha (q) events, transactivates EGFR via a PKC-mediated pathway by activation of MMP3 (Matrix Metalloproteinase 3) which allows formation of mature HBEGF (heparin-binding epidermal growth factor) by cleaving pro-HBEGF. Mature HBEGF is then free to bind the EGFR, resulting in EGFR activation (Dufresne et al. 2006, Liebmann 2011)
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer.	Signaling by PI3K/AKT is frequently constitutively activated in cancer via gain-of-function mutations in one of the two PI3K subunits - PI3KCA (encoding the catalytic subunit p110alpha) or PIK3R1 (encoding the regulatory subunit p85alpha). Gain-of-function mutations activate PI3K signaling by diverse mechanisms. Mutations affecting the helical domain of PIK3CA and mutations affecting nSH2 and iSH2 domains of PIK3R1 impair inhibitory interactions between these two subunits while preserving their association. Mutations in the catalytic domain of PIK3CA enable the kinase to achieve an active conformation. PI3K complexes with gain-of-function mutations therefore produce PIP3 and activate downstream AKT in the absence of growth factors (Huang et al. 2007, Zhao et al. 2005, Miled et al. 2007, Horn et al. 2008, Sun et al. 2010, Jaiswal et al. 2009, Zhao and Vogt 2010, Urick et al. 2011)
R-HSA-445144	Signal transduction by L1.	Besides adhesive roles in cell cell interaction, L1 functions as a signal transducing receptor providing neurons with cues from their environment for axonal growth and guidance. L1 associates with beta1 integrins on the cell surface to induce a signaling pathway involving sequential activation of pp60csrc, Vav2 -GEF, Rac1, PAK1, MEK and ERK1/2. L1 stimulates cell migration and neurite outgrowth through the MAP kinases ERK1/2. CHL1 also associates with integrins and activates a MAPK signaling pathway via pp60c-src, MEK and ERK1/2. L1 also binds the Sema3A receptor neuropilin1 and acts as an obligate coreceptor to mediate Sema3A induced growth cone collapse and axon repulsion. This repulsion can be converted to attraction by homophilic binding of L1 on an apposing cell in trans with L1 complexed with Neuropilin1 (NP1) in the responding neuron.L1 also interacts with FGF receptor and activates PLC gamma and DAG, resulting in the production of arachidonic acid and subsequent opening of voltage-gated channels
R-HSA-5637810	Constitutive Signaling by EGFRvIII.	In glioblastoma, the most prevalent EGFR mutation, present in ~25% of tumors, is the deletion of the ligand binding domain of EGFR, accompanied with amplification of the mutated allele, which results in over-expression of the mutant protein known as EGFRvIII. EGFRvIII mutant is not able to bind a ligand, but dimerizes and autophosphorylates spontaneously and is therefore constitutively active (Fernandes et al. 2001). Point mutations in the extracellular domain of EGFR are also frequently found in glioblastoma, but ligand binding ability and responsiveness are preserved (Lee et al. 2006). Similar to EGFR kinase domain mutants, EGFRvIII mutant needs to maintain association with the chaperone heat shock protein 90 (HSP90) for proper functioning (Shimamura et al. 2005, Lavictoire et al. 2003). CDC37 is a co-chaperone of HSP90 that acts as a scaffold and regulator of interaction between HSP90 and its protein kinase clients. CDC37 is frequently over-expressed in cancers involving mutant kinases and acts as an oncogene (Roe et al. 2004, reviewed by Gray Jr. et al. 2008). Expression of EGFRvIII mutant results in aberrant activation of downstream signaling cascades, namely RAS/RAF/MAP kinase signaling and PI3K/AKT signaling, and possibly signaling by PLCG1, which leads to increased cell proliferation and survival, providing selective advantage to cancer cells that harbor EGFRvIII (Huang et al. 2007). EGFRvIII mutant does not autophosorylate on the tyrosine residue Y1045, a docking site for CBL, and is therefore unable to recruit CBL ubiquitin ligase, which enables it to escape degradation (Han et al
R-HSA-5638303	Inhibition of Signaling by Overexpressed EGFR.	Recombinant monoclonal antibody Cetuximab acts as an antagonist of EGFR ligand binding, and is approved for the treatment of tumors that over-express wild-type EGFR receptor (Cunningham et al. 2004, Li et al. 2005, Burtness et al. 2005). Effective concentrations of covalent tyrosine kinase inhibitors (TKIs) inhibit wild-type EGFR, causing severe side effects (Zhou et al. 2009). Hence, covalent TKIs have not shown much promise in clinical trials (Reviewed by Pao and Chmielecki in 2010)
R-HSA-5673001	RAF/MAP kinase cascade.	The RAS-RAF-MEK-ERK pathway regulates processes such as proliferation, differentiation, survival, senescence and cell motility in response to growth factors, hormones and cytokines, among others. Binding of these stimuli to receptors in the plasma membrane promotes the GEF-mediated activation of RAS at the plasma membrane and initiates the three-tiered kinase cascade of the conventional MAPK cascades. GTP-bound RAS recruits RAF (the MAPK kinase kinase), and promotes its dimerization and activation (reviewed in Cseh et al, 2014; Roskoski, 2010; McKay and Morrison, 2007; Wellbrock et al, 2004). Activated RAF phosphorylates the MAPK kinase proteins MEK1 and MEK2 (also known as MAP2K1 and MAP2K2), which in turn phophorylate the proline-directed kinases ERK1 and 2 (also known as MAPK3 and MAPK1) (reviewed in Roskoski, 2012a, b; Kryiakis and Avruch, 2012). Activated ERK proteins may undergo dimerization and have identified targets in both the nucleus and the cytosol; consistent with this, a proportion of activated ERK protein relocalizes to the nucleus in response to stimuli (reviewed in Roskoski 2012b; Turjanski et al, 2007; Plotnikov et al, 2010; Cargnello et al, 2011). Although initially seen as a linear cascade originating at the plasma membrane and culminating in the nucleus, the RAS/RAF MAPK cascade is now also known to be activated from various intracellular location. Temporal and spatial specificity of the cascade is achieved in part through the interaction of pathway components with numerous scaffolding proteins (reviewed in McKay and Morrison, 2007; Brown and Sacks, 2009). The importance of the RAS/RAF MAPK cascade is highlighted by the fact that components of this pathway are mutated with high frequency in a large number of human cancers. Activating mutations in RAS are found in approximately one third of human cancers, while ~8% of tumors express an activated form of BRAF (Roberts and Der, 2007; Davies et al, 2002; Cantwell-Dorris et al, 2011)
R-HSA-6785631	ERBB2 Regulates Cell Motility.	Activated ERBB2 heterodimers regulate cell motility through association with MEMO1. MEMO1 retains activated RHOA GTPase and its associated protein DIAPH1 at the plasma membrane, thus linking ERBB2 activation with the microtubule and actin dynamics downstream of the RHOA:GTP:DIAPH1 complex (Marone et al. 2004, Qiu et al. 2008, Zaoui et al. 2008, Zaoui et al. 2010)
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.	Phosphatidylinositol-5-phosphate (PI5P) may modulate PI3K/AKT signaling in several ways. PI5P is used as a substrate for production of phosphatidylinositol-4,5-bisphosphate, PI(4,5)P2 (Rameh et al. 1997, Clarke et al. 2008, Clarke et al. 2010, Clarke and Irvine 2013, Clarke et al. 2015), which serves as a substrate for activated PI3K, resulting in the production of PIP3 (Mandelker et al. 2009, Burke et al. 2011). The majority of PI(4,5)P2 in the cell, however, is produced from the phosphatidylinositol-4-phosphate (PI4P) substrate (Zhang et al. 1997, Di Paolo et al. 2002, Oude Weernink et al. 2004, Halstead et al. 2006, Oude Weernink et al. 2007). PIP3 is necessary for the activating phosphorylation of AKT. AKT1 can be deactivated by the protein phosphatase 2A (PP2A) complex that contains a regulatory subunit B56-beta (PPP2R5B) or B56-gamma (PPP2R5C). PI5P inhibits AKT1 dephosphorylation by PP2A through an unknown mechanism (Ramel et al. 2009). Increased PI5P levels correlate with inhibitory phosphorylation(s) of the PP2A complex. MAPK1 (ERK2) and MAPK3 (ERK1) are involved in inhibitory phosphorylation of PP2A, in a process that involves IER3 (IEX-1) (Letourneux et al. 2006, Rocher et al. 2007). It is uncertain, however, whether PI5P is in any way involved in ERK-mediated phosphorylation of PP2A or if it regulates another PP2A kinase
R-HSA-8847993	ERBB2 Activates PTK6 Signaling.	PTK6 (BRK) is activated downstream of ERBB2 (HER) (Xiang et al. 2008, Peng et al. 2015) and other receptor tyrosine kinases, such as EGFR (Kamalati et al. 1996) and MET (Castro and Lange 2010). However, it is not clear if MET and EGFR activate PTK6 directly or act through ERBB2, since it is known that ERBB2 forms heterodimers with EGFR (Spivak-Kroizman et al. 1992), and MET can heterodimerize with both EGFR and ERBB2 (Tanizaki et al. 2011)
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis.	Recruitment of plasma membrane-localized cargo into clathrin-coated endocytic vesicles is mediated by interaction with a variety of clathrin-interacting proteins collectively called CLASPs (clathrin-associated sorting proteins). CLASP proteins, which may be monomeric or tetrameric, are recruited to the plasma membrane through interaction with phosphoinsitides and recognize linear or conformational sequences or post-translational modifications in the cytoplasmic tails of the cargo protein. Through bivalent interactions with clathrin and/or other CLASP proteins, they bridge the recruitment of the cargo to the emerging clathrin coated pit (reviewed in Traub and Bonifacino, 2013). The tetrameric AP-2 complex, first identified in early studies of clathrin-mediated endocytosis, was at one time thought to be the primary CLASP protein involved in cargo recognition at the plasma membrane, and indeed plays a key role in the endocytosis of cargo carrying dileucine- or tyrosine-based motifs. A number of studies have been performed to test whether AP-2 is essential for all forms of clathrin-mediated endocytosis (Keyel et al, 2006; Motely et al, 2003; Huang et al, 2004; Boucrot et al, 2010; Henne et al, 2010; Johannessen et al, 2006; Gu et al, 2013; reviewed in Traub, 2009; McMahon and Boucrot, 2011). Although depletion of AP-2 differentially affects the endocytosis of different cargo, extensive depletion of AP-2 through RNAi reduces clathrin-coated pit formation by 80-90%, and the CCPs that do form still contain AP-2, highlighting the critcical role of this complex in CME (Johannessen et al, 2006; Boucrot et al, 2010; Henne et al, 2010).In addition to AP-2, a wide range of other CLASPs including proteins of the beta-arrestin, stonin and epsin families, engage sorting motifs in other cargo and interact either with clathrin, AP-2 or each other to facilitate assembly of a clathin-coated pit (reviewed in Traub and Bonifacino, 2013)
R-HSA-8856828	Clathrin-mediated endocytosis.	Clathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1975; reviewed in Robinson, 2015; McMahon and Boucrot, 2011; Kirchhausen et al, 2014). CME contributes to signal transduction by regulating the cell surface expression and signaling of receptor tyrosine kinases (RTKs) and G-protein coupled receptors (GPCRs). Most RTKs exhibit a robust increase in internalization rate after binding specific ligands; however, some RTKs may also exhibit significant ligand-independent internalization (reviewed in Goh and Sorkin, 2013). CME controls RTK and GPCR signaling by organizing signaling both within the plasma membrane and on endosomes (reviewed in Eichel et al, 2016; Garay et al, 2015; Vieira et al, 1996; Sorkin and von Zastrow, 2014; Di Fiori and von Zastrow, 2014; Barbieri et al, 2016). CME also contributes to the uptake of material such as metabolites, hormones and other proteins from the extracellular space, and regulates membrane composition by recycling membrane components and/or targeting them for degradation. Clathrin-mediated endocytosis involves initiation of clathrin-coated pit (CCP) formation, cargo selection, coat assembly and stabilization, membrane scission and vesicle uncoating. Although for simplicity in this pathway, the steps leading to a mature CCP are represented in a linear and temporally distinct fashion, the formation of a clathrin-coated vesicle is a highly heterogeneous process and clear temporal boundaries between these processes may not exist (see for instance Taylor et al, 2011; Antonescu et al, 2011; reviewed in Kirchhausen et al, 2014). Cargo selection in particular is a critical aspect of the formation of a mature and stable CCP, and many of the proteins involved in the initiation and maturation of a CCP contribute to cargo selection and are themselves stabilized upon incorporation of cargo into the nascent vesicle (reviewed in Kirchhausen et al, 2014; McMahon and Boucrot, 2011).Although the clathrin triskelion was identified early as a major component of the coated vesicles, clathrin does not bind directly to membranes or to the endocytosed cargo. Vesicle formation instead relies on many proteins and adaptors that can bind the plasma membrane and interact with cargo molecules. Cargo selection depends on the recognition of endocytic signals in cytoplasmic tails of the cargo proteins by adaptors that interact with components of the vesicle's inner coat. The classic adaptor for clathrin-coated vesicles is the tetrameric AP-2 complex, which along with clathrin was identified early as a major component of the coat. Some cargo indeed bind directly to AP-2, but subsequent work has revealed a large family of proteins collectively known as CLASPs (clathrin- associated sorting proteins) that mediate the recruitment of diverse cargo into the emerging clathrin-coated vesicles (reviewed in Traub and Bonifacino, 2013). Many of these CLASP proteins themselves interact with AP-2 and clathrin, coordinating cargo recruitment with coat formation (Schmid et al, 2006; Edeling et al, 2006; reviewed in Traub and Bonifacino, 2013; Kirchhausen et al, 2014). Initiation of CCP formation is also influenced by lipid composition, regulated by clathrin-associated phosphatases and kinases (reviewed in Picas et al, 2016). The plasma membrane is enriched in PI(4,5)P2. Many of the proteins involved in initiating clathrin-coated pit formation bind to PI(4,5)P2 and induce membrane curvature through their BAR domains (reviewed in McMahon and Boucrot, 2011; Daumke et al, 2014). Epsin also contributes to early membrane curvature through its Epsin N-terminal homology (ENTH) domain, which promotes membrane curvature by inserting into the lipid bilayer (Ford et al, 2002). Following initiation, some CCPs progress to formation of vesicles, while others undergo disassembly at the cell surface without producing vesicles (Ehrlich et al, 2004; Loerke et al, 2009; Loerke et al, 2011; Aguet et al, 2013; Taylor et al, 2011). The assembly and stabilization of nascent CCPs is regulated by several proteins and lipids (Mettlen et al, 2009; Antonescu et al, 2011).Maturation of the emerging clathrin-coated vesicle is accompanied by further changes in the lipid composition of the membrane and increased membrane curvature, promoted by the recruitment of N-BAR domain containing proteins (reviewed in Daumke et al, 2014; Ferguson and De Camilli, 2012; Picas et al, 2016). Some N-BAR domain containing proteins also contribute to the recruitment of the large GTPase dynamin, which is responsible for scission of the mature vesicle from the plasma membrane (Koh et al, 2007; Lundmark and Carlsson, 2003; Soulet et al, 2005; David et al, 1996; Owen et al, 1998; Shupliakov et al, 1997; Taylor et al, 2011; Ferguson et al, 2009; Aguet et al, 2013; Posor et al, 2013; Chappie et al, 2010; Shnyrova et al, 2013; reviewed in Mettlen et al, 2009; Daumke et al, 2014). After vesicle scission, the clathrin coat is dissociated from the new vesicle by the ATPase HSPA8 (also known as HSC70) and its DNAJ cofactor auxilin, priming the vesicle for fusion with a subsequent endocytic compartment and releasing clathrin for reuse (reviewed in McMahon and Boucrot, 2011; Sousa and Laufer, 2015)
R-HSA-8857538	PTK6 promotes HIF1A stabilization.	HBEGF-stimulated formation of EGFR heterodimers with GPNMB triggers PTK6-mediated phosphorylation and stabilization of the hypoxia inducible factor 1 alpha (HIF1A) under normoxic conditions. This process depends on the presence of a long non-coding RNA LINC01139 (LINK-A) (Lin et al. 2016)
R-HSA-8863795	Downregulation of ERBB2 signaling.	Signaling by ERBB2 can be downregulated by ubiquitination and subsequent proteasome-dependent degradation of ERBB2 or activated ERBB2 heterodimers. In addition, protein tyrosine phosphatases that dephosphorylate tyrosine residues in the C-terminus of ERBB2 prevent the recruitment of adapter proteins involved in signal transduction, thus attenuating ERBB2 signaling.STUB1 (CHIP) and CUL5 are E3 ubiquitin ligases that can target non-activated ERBB2 for proteasome-dependent degradation (Xu et al. 2002, Ehrlich et al. 2009). RNF41 (NRDP1) is an E3 ubiquitin ligase that targets ERBB3 and activated heterodimers of ERBB2 and ERBB3 for proteasome-dependent degradation by ubiquitinating ERBB3 (Cao et al. 2007).Two protein tyrosine phosphatases of the PEST family, PTPN12 and PTPN18, dephosphorylate tyrosine residues in the C-terminus of ERBB2, thus preventing signal transduction to RAS and PI3K effectors (Sun et al. 2011, Wang et al. 2014)
R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.	TFAP2A and TFAP2C directly stimulate transcription of the estrogen receptor ESR1 gene (McPherson and Weigel 1999). TFAP2A expression correlates with ESR1 expression in breast cancer, and TFAP2C is frequently overexpressed in estrogen-positive breast cancer and endometrial cancer (deConinck et al. 1995, Turner et al. 1998). TFAP2A, TFAP2C, as well as TFAP2B can directly stimulate the expression of ERBB2, another important breast cancer gene (Bosher et al. 1996). Association of TFAP2A with the YY1 transcription factor significantly increases the ERBB2 transcription rate (Begon et al. 2005). In addition to ERBB2, the expression of another receptor tyrosine kinase, KIT, is also stimulated by TFAP2A and TFAP2B (Huang et al. 1998), while the expression of the VEGF receptor tyrosine kinase ligand VEGFA is repressed by TFAP2A (Ruiz et al. 2004, Li et al. 2012). TFAP2A stimulates transcription of the transforming growth factor alpha (TGFA) gene (Wang et al. 1997). TFAP2C regulates EGFR expression in luminal breast cancer (De Andrade et al. 2016). In placenta, TFAP2A and TFAP2C directly stimulate transcription of both subunits of the human chorionic gonadotropin, CGA and CGB (Johnson et al. 1997, LiCalsi et al. 2000)
R-HSA-9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus.	NOTCH3 receptor can be activated by DLL/JAG ligands DLL1, JAG1, and JAG2 (Shimizu et al. 2000), as well as DLL4 (Claxton and Fruttiger 2004, Indraccolo et al. 2009). Ligand binding induces a conformational change in NOTCH3, which exposes the S2 site in the extracellular region of NOTCH3. The S2 site is cleaved by ADAM10 metalloprotease, generating the membrane anchored NOTCH3 fragment NEXT3. The NEXT3 fragment of NOTCH3 is further cleaved at the S3 site by the gamma secretase complex, releasing the intracellular domain NICD3 into the cytosol (Groot et al. 2014). Besides DLL/JAG ligands, NOTCH3 signaling can also be activated by binding of NOTCH3 to YBX1 (YB 1) (Rauen et al. 2009). NICD3 traffics to the nucleus where it acts as a transcription factor. WWP2, an E3 ubiquitin ligase, negatively regulates NOTCH3 signaling by ubiquitinating NEXT3 and NICD3 in the cytosol and targeting them for lysosome-mediated degradation (Jung et al. 2014). NOTCH3 signaling is also negatively regulated by binding to TACC3 (Bargo et al. 2010) and by EGFR-mediated phosphorylation (Arasada et al. 2014)

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Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
AAMDC	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AAMP	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AASDH	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ABCA1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ABCD3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ABCF2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ABL1	PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
ABL2	PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
ACACA	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ACACB	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ACADSB	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ACOT9	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
ACP1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ACTA2	Affinity Capture-MS	physical	19531499, (Europe PMC)	NA	BioGRID
ACTB	Affinity Capture-Western	physical	22366308, (Europe PMC)	NA	BioGRID
ACTN4	Affinity Capture-Luminescence, PCA, Two-hybrid	physical	24658140, 25402006, (Europe PMC)	NA	BioGRID
ACTR2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ADAM5	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ADAR	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ADRM1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
AFG3L2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AGTPBP1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
AHNAK	Affinity Capture-MS, PCA, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	20029029, 24189400, (Europe PMC)	0.55	BioGRID, IntAct
AHSA1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
AHSG	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
AIFM1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AIP	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
AK4	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AKAP12	PCA, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.51	BioGRID, IntAct
AKAP17A	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
AKT1	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
AKT2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AKTIP	Affinity Capture-Western	physical	25151576, 27535835, (Europe PMC)	NA	BioGRID
ALCAM	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
ALDH3A2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
ALDH7A1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ALDOA	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
ANKRD13A	Affinity Capture-MS, Affinity Capture-Western	physical	22298428, 23956138, (Europe PMC)	NA	BioGRID
ANKRD13B	Affinity Capture-Western	physical	22298428, (Europe PMC)	NA	BioGRID
ANKRD13D	Affinity Capture-Western	physical	22298428, (Europe PMC)	NA	BioGRID
ANKS1A	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, anti tag coimmunoprecipitation, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.66	BioGRID, IntAct, MINT
ANKS1B	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
ANO5	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
ANXA1	Affinity Capture-MS, anti tag coimmunoprecipitation, imaging technique, tandem affinity purification, ubiquitin reconstruction	association, colocalization, physical, physical association	15581623, 20029029, 24189400, (Europe PMC)	0.70	BioGRID, IntAct, MINT
AP1B1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
AP1G1	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
AP1G2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
AP1M1	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
AP1M2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
AP1S1	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
AP1S2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AP2A1	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	20029029, 23956138, 24189400, 24797263, (Europe PMC)	0.53	BioGRID, IntAct
AP2A2	Affinity Capture-MS, tandem affinity purification	association, physical	23956138, 24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
AP2B1	Affinity Capture-MS, tandem affinity purification	association, physical	23956138, 24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
AP2M1	Affinity Capture-MS, PCA, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	20029029, 23956138, 24189400, 24797263, (Europe PMC)	0.55	BioGRID, IntAct
AP2S1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
AP3D1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AP3M1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AP3S1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
APBA3	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
APBB1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
APBB2	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, luminescence based mammalian interactome mapping, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.66	BioGRID, IntAct, MINT
APBB3	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
APEX1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
API5	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
APOB	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
APP	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
APPL1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
APRT	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AR	Affinity Capture-Western, Co-localization	physical	15288768, 15305378, (Europe PMC)	NA	BioGRID
AREG	Reconstituted Complex	physical	10085134, (Europe PMC)	NA	BioGRID
ARF4	Affinity Capture-Western, Two-hybrid	physical	12446727, (Europe PMC)	NA	BioGRID
ARF6	Affinity Capture-MS, PCA	physical	20029029, 24797263, (Europe PMC)	NA	BioGRID
ARFGEF1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
ARFGEF3	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
ARHGAP1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ARHGAP29	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ARHGAP32	Affinity Capture-Western	physical	12446789, (Europe PMC)	NA	BioGRID
ARHGEF2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ARHGEF5	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
ARHGEF7	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
ARL1	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
ARMC6	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ARMC8	Affinity Capture-MS, tandem affinity purification	association, physical	23956138, 24189400, (Europe PMC)	0.35	BioGRID, IntAct
ARMCX5	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ARRB1	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
ARRB2	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
ASNS	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ATAD1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ATAD3B	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ATF7IP2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ATIC	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
ATP1A1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, 24797263, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
ATP1B1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
ATP2A2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	15657067, 23956138, 24189400, (Europe PMC)	0.53	BioGRID, IntAct
ATP2B1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ATP2B4	Affinity Capture-MS	physical	24189400, (Europe PMC)	NA	BioGRID
ATP5F1A	Affinity Capture-MS	physical	24189400, 24797263, (Europe PMC)	NA	BioGRID
ATP5F1C	Affinity Capture-MS, Two-hybrid	physical	16169070, 19531499, (Europe PMC)	NA	BioGRID
ATP5MG	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ATP5PB	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ATP6V1H	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
ATR	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
ATXN10	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, (Europe PMC)	0.35	BioGRID, IntAct
ATXN2	Affinity Capture-Western	physical	18602463, (Europe PMC)	NA	BioGRID
ATXN7L3B	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
BABAM2	Affinity Capture-MS	physical	24780295, (Europe PMC)	NA	BioGRID
BAG2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
BAG5	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
BAIAP2	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	24189400, 24658140, 25402006, (Europe PMC)	0.55	BioGRID, IntAct
BBC3	Affinity Capture-Western	physical	20153921, (Europe PMC)	NA	BioGRID
BBS10	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
BCCIP	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
BCLAF1	Affinity Capture-MS	physical	18271526, 24797263, 28065597, (Europe PMC)	NA	BioGRID
BIRC2	Affinity Capture-Western	physical	23972990, (Europe PMC)	NA	BioGRID
BIRC3	Affinity Capture-Western	physical	23972990, (Europe PMC)	NA	BioGRID
BLK	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
BLM	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
BMX	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
BPTF	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
BRAF	Negative Genetic	genetic	28319113, (Europe PMC)	NA	BioGRID
BTAF1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
BTBD18	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
BUB3	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
BZW1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
BZW2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
C2orf49	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
C6orf120	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CALM1	Affinity Capture-MS, Affinity Capture-Western, PCA, Reconstituted Complex, Two-hybrid	physical	12359306, 14960328, 16799092, 24658140, 25402006, (Europe PMC)	NA	BioGRID
CALR	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CALU	Co-fractionation	physical	22939629, (Europe PMC)	NA	BioGRID
CAMLG	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	12919676, 24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
CANX	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
CAP2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CAPRIN1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CARS2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CASP1	Biochemical Activity	physical	11226410, (Europe PMC)	NA	BioGRID
CAV1	Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, PCA, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	10781609, 12388423, 15273741, 15657067, 16407214, 16799092, 19446582, 22411794, 24658140, 25402006, 9374534, (Europe PMC)	0.75	BioGRID, IntAct
CAV2	Affinity Capture-MS, PCA, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	15273741, 16799092, 24658140, 25402006, (Europe PMC)	0.55	BioGRID, IntAct
CAV3	Affinity Capture-Western, Reconstituted Complex	physical	9374534, (Europe PMC)	NA	BioGRID
CAVIN1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
CBL	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, far western blotting, fluorescence microscopy, isothermal titration calorimetry, pull down, x-ray crystallography	association, colocalization, direct interaction, physical, physical association	10086340, 10428778, 10635327, 11239464, 11370743, 11408594, 12061819, 12593795, 12604776, 12734385, 12803489, 14505571, 14627991, 15107835, 15117950, 15159412, 15210722, 15282549, 15383614, 15465819, 15657067, 15668240, 15677445, 15735736, 15962011, 16105874, 16246327, 16729043, 16849543, 16914641, 16923119, 16969069, 17182860, 17242169, 17486068, 17545148, 17880946, 17971399, 17995934, 18271526, 18273061, 18316398, 18508924, 19155296, 19225046, 19531499, 19578043, 19713535, 19836242, 19947936, 20124286, 20308550, 20562913, 20877636, 20940296, 21772844, 22203672, 22266821, 22394513, 22591401, 22833562, 22976291, 23153581, 23158001, 23175185, 23418353, 23457600, 23774213, 23799367, 23897813, 24714105, 24797263, 25140053, 25521828, 25872741, 26055326, 26177020, 27059931, 28198003, 28791635, 7592693, 7657591, 7782294, 8662998, 9121472, 9130710, 9756944, (Europe PMC)	0.96	BioGRID, IntAct, MINT
CBLB	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation	association, physical	10086340, 10635327, 11375397, 15657067, 16702950, 16729043, 18271526, 19531499, 20308550, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
CBLC	Affinity Capture-Western, Co-crystal Structure, Protein-peptide, Reconstituted Complex	physical	10362357, 10571044, 22888118, (Europe PMC)	NA	BioGRID
CBR1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
CBX2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CBY1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CCDC146	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CCDC47	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CCDC50	Affinity Capture-Western	physical	16803894, (Europe PMC)	NA	BioGRID
CCDC60	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CCDC88A	Co-localization	physical	15882442, (Europe PMC)	NA	BioGRID
CD2AP	Affinity Capture-Western	physical	12672817, (Europe PMC)	NA	BioGRID
CD300LB	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CD44	Affinity Capture-Western	physical	12093135, 15597342, 23265944, (Europe PMC)	NA	BioGRID
CD58	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CD59	FRET, fluorescent resonance energy transfer	direct interaction, physical	12577067, (Europe PMC)	0.44	BioGRID, IntAct
CD82	Affinity Capture-Western	physical	10985391, (Europe PMC)	NA	BioGRID
CDC25A	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	11912208, (Europe PMC)	NA	BioGRID
CDC25C	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
CDC37	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, luminescence based mammalian interactome mapping, tandem affinity purification	association, physical, physical association	12471035, 23956138, 24189400, 25036637, (Europe PMC)	0.62	BioGRID, IntAct
CDH1	Affinity Capture-MS, Affinity Capture-Western, Co-localization, PCA, Proximity Label-MS, Two-hybrid, proximity ligation assay, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	10969083, 24189400, 24658140, 25241761, 25402006, 25468996, (Europe PMC)	0.68	BioGRID, IntAct
CDH2	Affinity Capture-Western	physical	19033391, (Europe PMC)	NA	BioGRID
CDH5	PCA, Two-hybrid	physical	24658140, 25402006, (Europe PMC)	NA	BioGRID
CDIPT	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CDK1	Affinity Capture-MS, PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	15657067, 18271526, 23956138, 24658140, 25402006, (Europe PMC)	0.55	BioGRID, IntAct
CDK13	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CDK5	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CEBPB	Affinity Capture-Western	physical	12095417, (Europe PMC)	NA	BioGRID
CEBPZ	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CEMIP2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CEND1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
CENPL	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CEP104	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CEP170	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CERS2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CES4A	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CFL1	PCA, ubiquitin reconstruction	physical, physical association	20029029, 24658140, (Europe PMC)	0.55	BioGRID, IntAct
CFTR	Affinity Capture-MS	physical	26618866, (Europe PMC)	NA	BioGRID
CHCHD3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CHD6	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CHMP4A	Affinity Capture-Western	physical	23477725, (Europe PMC)	NA	BioGRID
CIP2A	Affinity Capture-MS, Affinity Capture-Western	physical	23956138, (Europe PMC)	NA	BioGRID
CIRBP	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CISH	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, luminescence based mammalian interactome mapping, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.66	BioGRID, IntAct, MINT
CKAP2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CKMT1A	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CLCN5	Affinity Capture-MS	physical	24780295, (Europe PMC)	NA	BioGRID
CLNK	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
CLPP	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CLPX	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CLTA	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
CLTCL1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
CLU	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CMSS1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CNBP	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CNOT9	Affinity Capture-Western, Reconstituted Complex	physical	20878056, (Europe PMC)	NA	BioGRID
CNP	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CNPY3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CNTF	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CNTN2	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
COA3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
COG1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
COG4	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
COG5	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
COG6	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
COG7	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
COL17A1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
COL1A1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
COL1A2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
COL9A3	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
COPA	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
COQ8A	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
COX2	Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Protein-peptide	physical	15282306, 24797263, (Europe PMC)	NA	BioGRID
CPVL	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CRCT1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CRK	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, PCA, Protein-peptide, Two-hybrid, luminescence based mammalian interactome mapping, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	10595738, 16273093, 16729043, 24658140, 25402006, 9617486, 9642287, (Europe PMC)	0.51, 0.59	BioGRID, IntAct, MINT
CRKL	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, proximity ligation assay, pull down, ubiquitin reconstruction	physical, physical association	16729043, 18271526, 23397142, 24658140, 25402006, (Europe PMC)	0.69	BioGRID, IntAct, MINT
CSE1L	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
CSK	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, pull down, ubiquitin reconstruction	physical, physical association	16729043, 24658140, 24797263, 25402006, (Europe PMC)	0.57	BioGRID, IntAct, MINT
CSNK1A1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CSNK2A1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CSRP1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
CSTA	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
CSTF3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CTBP1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CTBP2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CTCFL	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CTDSPL	Proximity Label-MS	physical	27880917, (Europe PMC)	NA	BioGRID
CTGF	Affinity Capture-Western	physical	23175185, (Europe PMC)	NA	BioGRID
CTNNA1	Affinity Capture-MS, Co-localization, anti bait coimmunoprecipitation, proximity ligation assay, tandem affinity purification	association, physical, physical association	15657067, 24189400, 25241761, (Europe PMC)	0.67	BioGRID, IntAct
CTNNA2	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
CTNNB1	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, tandem affinity purification	association, physical	11950845, 24189400, 9233779, 9535896, (Europe PMC)	0.35	BioGRID, IntAct
CTNND1	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	15657067, 24189400, 24658140, 24797263, 25402006, 27316454, 9535896, (Europe PMC)	0.66	BioGRID, IntAct
CTSD	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
CTTN	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	24658140, 24797263, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
CUL4B	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
CYS1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
DARS	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
DAZL	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
DBR1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
DCBLD2	Biochemical Activity	physical	25061874, (Europe PMC)	NA	BioGRID
DCN	Reconstituted Complex, Two-hybrid	physical	12105206, 9988678, (Europe PMC)	NA	BioGRID
DCTN2	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
DDX20	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
DDX47	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
DDX5	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
DDX60	Affinity Capture-MS	physical	18271526, (Europe PMC)	NA	BioGRID
DEFA1	Affinity Capture-MS	physical	28514442, (Europe PMC)	NA	BioGRID
DERL1	Affinity Capture-Western	physical	23306155, (Europe PMC)	NA	BioGRID
DHCR24	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
DHFR	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
DHRS7B	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
DHX16	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
DHX38	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
DHX9	Affinity Capture-MS	physical	24780295, (Europe PMC)	NA	BioGRID
DIMT1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
DIP2A	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
DIS3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
DIXDC1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
DNAAF5	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
DNAH7	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
DNAH8	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
DNAJA1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
DNAJA2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	15657067, 23956138, 24189400, 24797263, (Europe PMC)	0.53	BioGRID, IntAct
DNAJA3	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical	15657067, 23698466, 23956138, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
DNAJB11	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
DNAJB12	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
DNAJC11	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
DNAJC13	Affinity Capture-MS, fluorescence microscopy	colocalization, physical	21510942, 28065597, (Europe PMC)	0.27	BioGRID, IntAct, MINT
DNAJC4	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
DNM1L	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
DNM2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
DOCK10	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
DOCK4	Affinity Capture-MS	physical	18271526, (Europe PMC)	NA	BioGRID
DOK1	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
DOK2	Reconstituted Complex	physical	10508618, (Europe PMC)	NA	BioGRID
DOK4	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
DOK5	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
DOK6	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
DOP1A	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
DOP1B	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
DPEP3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
DPM1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
DPP4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
DRD2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
DSG2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
DUSP14	Affinity Capture-Western	physical	28065597, (Europe PMC)	NA	BioGRID
DUSP18	Affinity Capture-Western	physical	28065597, (Europe PMC)	NA	BioGRID
DUSP19	Two-hybrid	physical	28065597, (Europe PMC)	NA	BioGRID
DUSP3	Biochemical Activity	physical	1281549, (Europe PMC)	NA	BioGRID
DYNC1H1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
DYNC1LI1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
DYRK3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
E2F4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ECPAS	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
EDEM1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
EEF1A1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, (Europe PMC)	0.35	BioGRID, IntAct
EEF1B2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
EEF1G	Affinity Capture-MS, PCA, ubiquitin reconstruction	physical, physical association	20029029, 28065597, (Europe PMC)	0.37	BioGRID, IntAct
EFCAB3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
EGF	Affinity Capture-Luminescence, Affinity Capture-MS, Co-crystal Structure, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, fluorescence-activated cell sorting, molecular sieving, proximity ligation assay, saturation binding, scintillation proximity assay, surface plasmon resonance, transmission electron microscopy, x ray scattering, x-ray crystallography	direct interaction, physical, physical association	10085134, 12093292, 12297050, 12620237, 17697999, 18271526, 19531499, 21439278, 21822280, 22729867, 23597562, 25080504, 25241761, 25453753, 26280537, 2790960, (Europe PMC)	0.96	BioGRID, IntAct, MINT
EGFR	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-purification, FRET, PCA, Reconstituted Complex, anti tag coimmunoprecipitation, beta galactosidase complementation, comigration in non denaturing gel electrophoresis, fluorescence correlation spectroscopy, fluorescence microscopy, fluorescent resonance energy transfer, light scattering, nuclear magnetic resonance, phosphotransferase assay, protein cross-linking with a bifunctional reagent, protein kinase assay, proximity ligation assay, ubiquitin reconstruction, x-ray crystallography	colocalization, direct interaction, phosphorylation reaction, phosphotransfer reaction, physical, physical association	11087732, 12297049, 12297050, 12620237, 14576349, 16777603, 17148612, 18042729, 18271526, 19225046, 19560417, 19563760, 19650109, 20007378, 20029029, 20359299, 20456371, 21278786, 21480528, 21482778, 21775422, 22232519, 22579287, 23273428, 23374349, 23436906, 23595626, 23636329, 23794705, 23956138, 23972990, 24077285, 24135280, 24797263, 25453753, 2732223, 28065597, 2915986, 6321473, 8870675, 9092812, (Europe PMC)	0.98	BioGRID, IntAct
EHD1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
EHD4	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
EIF1AY	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
EIF2AK2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
EIF2B1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
EIF2B2	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
EIF2B3	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
EIF2B4	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
EIF2B5	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
EIF3B	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
EIF3F	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
EIF3K	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
EIF3M	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
EIF4B	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
EIF4G2	Affinity Capture-MS	physical	24797263, 28065597, (Europe PMC)	NA	BioGRID
EIF5B	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ELP1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ELP4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
EMC3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
EMD	Affinity Capture-MS, Co-fractionation	physical	20937808, 24797263, 28065597, (Europe PMC)	NA	BioGRID
EML6	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
EPB41L2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
EPHA2	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
EPN1	Affinity Capture-Western	physical	15701692, 19054389, 21226813, (Europe PMC)	NA	BioGRID
EPRS	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
EPS15	Affinity Capture-Western, Co-localization, anti bait coimmunoprecipitation	association, physical	15701692, 16429130, 16499958, 19109251, 21226813, 9049247, (Europe PMC)	0.35	BioGRID, IntAct
EPS8	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	11408594, 24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
ERBB2	Affinity Capture-MS, Affinity Capture-Western, Co-localization, anti bait coimmunoprecipitation, beta galactosidase complementation, protein cross-linking with a bifunctional reagent, protein kinase assay, proximity ligation assay, pull down, tandem affinity purification	association, physical, physical association	10572067, 11408594, 15657067, 16207817, 16516204, 16843263, 17148612, 17307140, 17486068, 18803307, 19060928, 19650109, 20211985, 21044682, 21203579, 21278786, 23436906, 23866081, 24189400, 24557338, 25241761, (Europe PMC)	0.96	BioGRID, IntAct, MINT
ERBB3	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, beta galactosidase complementation, protein cross-linking with a bifunctional reagent, proximity ligation assay, tandem affinity purification	association, physical, physical association	10527633, 10572067, 17148612, 18803307, 21278786, 22439932, 23436906, 23866081, 24189400, (Europe PMC)	0.92	BioGRID, IntAct
ERBB4	Affinity Capture-Western, FRET, anti bait coimmunoprecipitation	physical, physical association	10572067, 23153581, 25140053, (Europe PMC)	0.40	BioGRID, IntAct
ERCC1	Affinity Capture-MS, Affinity Capture-Western, Co-localization, anti bait coimmunoprecipitation, confocal microscopy, proximity ligation assay	association, colocalization, physical, physical association	24780295, (Europe PMC)	0.60	BioGRID, IntAct
ERCC2	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
ERCC4	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
EREG	Affinity Capture-Luminescence	physical	9419975, (Europe PMC)	NA	BioGRID
ERRFI1	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, anti bait coimmunoprecipitation, classical fluorescence spectroscopy, tandem affinity purification, x-ray crystallography	association, direct interaction, physical	18046415, 18271526, 18776048, 19531499, 19815557, 23273428, 23956138, 24189400, 24797263, 26280531, 28065597, (Europe PMC)	0.83	BioGRID, IntAct
ESR1	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	physical, physical association	17284441, 20935677, 28065597, (Europe PMC)	0.40, 0.52	BioGRID, IntAct, MINT
ESRRB	Affinity Capture-MS	physical	24189400, (Europe PMC)	NA	BioGRID
ETF1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
EWSR1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
EXOC3	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	23956138, 25594178, (Europe PMC)	0.40	BioGRID, IntAct
EXOC4	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical, physical association	23956138, 25594178, (Europe PMC)	0.50	BioGRID, IntAct
EXOC5	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
EXOC6	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
EXOC6B	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
EXOC7	Affinity Capture-MS, anti bait coimmunoprecipitation, fluorescence microscopy	colocalization, physical, physical association	23956138, 25594178, (Europe PMC)	0.46	BioGRID, IntAct
EXOC8	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	23956138, 25594178, (Europe PMC)	0.40	BioGRID, IntAct
EXOSC3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
EYS	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
EZR	PCA, ubiquitin reconstruction	physical, physical association	24658140, (Europe PMC)	0.37	BioGRID, IntAct
FADS2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
FAF2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
FAH	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
FAM126B	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
FAM129B	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	26721396, (Europe PMC)	NA	BioGRID
FAM186A	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
FAM66E	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
FAM98A	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
FAR1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
FARSA	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
FBL	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
FBLN7	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
FBXO25	Biochemical Activity	physical	23940030, (Europe PMC)	NA	BioGRID
FBXO6	Affinity Capture-MS	physical	22268729, 23956138, (Europe PMC)	NA	BioGRID
FDFT1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
FDPS	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
FEN1	Affinity Capture-MS	physical	24780295, (Europe PMC)	NA	BioGRID
FER	Affinity Capture-MS, Affinity Capture-Western	physical	18271526, 7623846, (Europe PMC)	NA	BioGRID
FES	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
FGR	Affinity Capture-Luminescence, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
FKBP4	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
FKBP8	PCA, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.58	BioGRID, IntAct
FLOT2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
FN1	PCA, anti tag coimmunoprecipitation	physical, physical association	20029029, (Europe PMC)	0.40	BioGRID, IntAct
FN3KRP	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
FOS	Co-localization, proximity ligation assay	physical, physical association	25241761, (Europe PMC)	0.40	BioGRID, IntAct
FOXO3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
FRK	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
FUS	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
G3BP1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
GAB1	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	11432805, 18271526, 21278788, 23066441, 24658140, 25402006, 9890893, (Europe PMC)	0.55	BioGRID, IntAct
GABARAPL2	PCA, pull down, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.51	BioGRID, IntAct
GABRA3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
GAPDH	Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	16799092, 20029029, 23956138, 24658140, 25402006, (Europe PMC)	0.72	BioGRID, IntAct
GBF1	Affinity Capture-MS	physical	23956138, 28065597, (Europe PMC)	NA	BioGRID
GCLM	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
GCN1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
GEMIN4	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
GEMIN6	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
GIGYF2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
GLUL	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
GNAS	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
GNB2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
GOLGB1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
GOT1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
GPATCH2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
GPATCH8	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
GPM6B	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
GPNMB	Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down	direct interaction, physical, physical association	26751287, (Europe PMC)	0.52, 0.54	BioGRID, IntAct
GPR149	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
GRAP2	Affinity Capture-Luminescence, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
GRB10	PCA, Reconstituted Complex, Two-hybrid, pull down, two hybrid, ubiquitin reconstruction	direct interaction, physical, physical association	24658140, 25402006, 9506989, (Europe PMC)	0.65	BioGRID, IntAct, MINT
GRB14	Reconstituted Complex	physical	8647858, (Europe PMC)	NA	BioGRID
GRB2	Affinity Capture-MS, Affinity Capture-Western, PCA, Protein-peptide, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, competition binding, protein array, pull down, surface plasmon resonance, tandem affinity purification, ubiquitin reconstruction	association, direct interaction, physical, physical association	10026169, 10085134, 10229072, 10595738, 11370743, 11408594, 11896612, 11960376, 12577067, 1322798, 14679214, 15657067, 16273093, 16729043, 16799092, 17242169, 17971399, 18271526, 19254954, 19289468, 19531499, 19836242, 20124286, 20473329, 21278786, 21278788, 21596750, 21706016, 23178716, 23799367, 23956138, 24189400, 24658140, 24797263, 25402006, 27059931, 7506413, 7510700, 7518560, 7527043, 7592693, 7650032, 8647858, 8662998, 8810340, 8887653, 8940013, 9020117, 9050991, 9416834, 9886492, (Europe PMC)	0.98	BioGRID, IntAct, MINT
GRID1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
GRIK4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
GRM4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
GRN	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
GSDME	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
GSTK1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
GSTP1	Affinity Capture-Western, Biochemical Activity	physical	19254954, 26429914, (Europe PMC)	NA	BioGRID
GSTT1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
H1FX	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
H2AFX	Affinity Capture-MS, Affinity Capture-Western	physical	21704408, 28065597, (Europe PMC)	NA	BioGRID
HADHB	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
HBA1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
HBA2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
HBEGF	Affinity Capture-Western, Reconstituted Complex	physical	12725245, 15358134, (Europe PMC)	NA	BioGRID
HCFC1	Affinity Capture-MS	physical	18271526, (Europe PMC)	NA	BioGRID
HCK	PCA, Two-hybrid, proximity ligation assay, ubiquitin reconstruction	physical, physical association	23397142, 24658140, 25402006, (Europe PMC)	0.57	BioGRID, IntAct
HDAC1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HDAC6	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay, ubiquitin reconstruction	association, phosphorylation reaction, physical, physical association	20029029, 20133936, 24658140, 25402006, (Europe PMC)	0.75	BioGRID, IntAct
HDAC7	Affinity Capture-Luminescence, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
HDGF	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HEATR3	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
HEATR4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HECW2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HELLS	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
HERC1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HERC2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HEXDC	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HEXIM1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
HGS	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation	physical, physical association	15212941, 18508924, 20308550, 23153581, 23477725, 23602387, 25588945, (Europe PMC)	0.40	BioGRID, IntAct
HIP1	Affinity Capture-Western	physical	17440072, (Europe PMC)	NA	BioGRID
HIST1H2AA	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
HIST2H2AA3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HK1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
HK2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
HLA-A	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
HLA-B	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HMGA1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HMGB1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HMGB2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HMGN2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HNRNPH1	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	15657067, 18271526, 24189400, (Europe PMC)	0.53	BioGRID, IntAct
HNRNPK	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
HNRNPL	Affinity Capture-RNA	physical	28611215, (Europe PMC)	NA	BioGRID
HOOK2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
HOXC10	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
HPN	Biochemical Activity	physical	19911255, (Europe PMC)	NA	BioGRID
HRNR	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HSD11B1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HSD17B10	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
HSD17B12	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
HSP90AA1	Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	12006493, 12471035, 16024644, 16849543, 20029029, 23956138, 24189400, 24658140, 25402006, (Europe PMC)	0.67	BioGRID, IntAct
HSP90AB1	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	12471035, 15657067, 20029029, 22939624, 23956138, 24189400, 24658140, 25402006, (Europe PMC)	0.84	BioGRID, IntAct
HSP90B1	Affinity Capture-MS, PCA, ubiquitin reconstruction	physical, physical association	12471035, 20029029, 28065597, (Europe PMC)	0.37	BioGRID, IntAct
HSPA1A	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid	physical	20029029, 24189400, 24658140, 25402006, (Europe PMC)	NA	BioGRID
HSPA1B	Co-localization	physical	25241761, (Europe PMC)	NA	BioGRID
HSPA2	Affinity Capture-MS, tandem affinity purification	association, physical	23956138, 24189400, (Europe PMC)	0.35	BioGRID, IntAct
HSPA4	Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	12006493, 18271526, 20029029, 24658140, 25402006, (Europe PMC)	0.55	BioGRID, IntAct
HSPA5	Affinity Capture-MS	physical	12471035, 23956138, 24189400, 28065597, (Europe PMC)	NA	BioGRID
HSPA8	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, anti bait coimmunoprecipitation, luminescence based mammalian interactome mapping, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	12471035, 15657067, 20029029, 23956138, 24189400, 24658140, 25402006, 28065597, (Europe PMC)	0.72	BioGRID, IntAct
HSPA9	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	15657067, 20029029, 24189400, 28065597, (Europe PMC)	0.66	BioGRID, IntAct
HSPB1	Affinity Capture-MS, anti bait coimmunoprecipitation, proximity ligation assay, tandem affinity purification	association, physical, physical association	15657067, 23397142, 24189400, (Europe PMC)	0.67	BioGRID, IntAct
HTATSF1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
HTR3A	Affinity Capture-MS	physical	28514442, (Europe PMC)	NA	BioGRID
HTT	Affinity Capture-Western	physical	9079622, (Europe PMC)	NA	BioGRID
HUWE1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
HYOU1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
IARS	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
ICAM1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
IDH2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
IDH3A	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
IDH3B	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
IDH3G	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
IFIT5	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
IGF1R	Affinity Capture-Western	physical	17047074, 17307140, (Europe PMC)	NA	BioGRID
IGFBP2	Affinity Capture-Western, Co-localization	physical	25893308, (Europe PMC)	NA	BioGRID
IGHG1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
IGHG3	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
IGHV1-2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
IGKC	Affinity Capture-MS	physical	23956138, 28065597, (Europe PMC)	NA	BioGRID
IGLL5	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
IKBKG	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
IL1RAPL2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ILF2	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
ILF3	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
ILKAP	Two-hybrid	physical	28065597, (Europe PMC)	NA	BioGRID
ILVBL	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
IMMT	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
INCENP	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ING4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
INPPL1	Affinity Capture-Western	physical	11349134, 19713535, (Europe PMC)	NA	BioGRID
IPO11	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
IPO13	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
IPO4	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
IPO5	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
IPO7	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
IPO8	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
IPO9	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
IQGAP1	Affinity Capture-Western, anti bait coimmunoprecipitation, confocal microscopy, pull down	colocalization, direct interaction, physical, physical association	19114553, 21349850, (Europe PMC)	0.63	BioGRID, IntAct
IQGAP3	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
IRAK1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
IRS1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
IRS2	Affinity Capture-MS	physical	18271526, (Europe PMC)	NA	BioGRID
IRS4	Affinity Capture-MS, Protein-peptide, protein array	direct interaction, physical	16273093, 24797263, (Europe PMC)	0.44	BioGRID, IntAct, MINT
ITCH	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ITGB1	FRET	physical	23595626, (Europe PMC)	NA	BioGRID
ITGB2	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
ITGB4	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
ITIH2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
ITK	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
ITPA	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ITSN2	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
JAK1	Affinity Capture-MS	physical	18271526, (Europe PMC)	NA	BioGRID
JAK2	Affinity Capture-Western, Biochemical Activity, Protein-peptide, protein array	direct interaction, physical	10358079, 16273093, 23838182, (Europe PMC)	0.44	BioGRID, IntAct, MINT
JPT1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
JUP	Affinity Capture-MS, PCA, Reconstituted Complex, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 24797263, 25402006, 9535896, (Europe PMC)	0.37	BioGRID, IntAct
KATNBL1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
KBTBD7	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
KCNQ1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
KCTD9P2	PCA	physical	20029029, (Europe PMC)	NA	BioGRID
KEAP1	Affinity Capture-Western, Biochemical Activity	physical	25628777, (Europe PMC)	NA	BioGRID
KIAA1217	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
KIF1A	Affinity Capture-MS	physical	24797263, 28065597, (Europe PMC)	NA	BioGRID
KPNB1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
KRAS	Synthetic Lethality	genetic	26627737, (Europe PMC)	NA	BioGRID
KRT1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
KRT10	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
KRT16	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
KRT2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
KRT3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
KRT5	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
KRT86	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
KRT9	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
KRTAP10-9	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
KRTAP15-1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
KRTAP16-1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
L1CAM	Affinity Capture-Western	physical	22815787, (Europe PMC)	NA	BioGRID
LANCL1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
LANCL2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
LARP4	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
LAT	Affinity Capture-Luminescence, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
LCA5L	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
LCP2	Affinity Capture-Luminescence, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
LGALS1	Affinity Capture-MS, Affinity Capture-Western	physical	19225046, 23956138, (Europe PMC)	NA	BioGRID
LGALS3	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation	physical, physical association	19225046, 21258405, 23956138, (Europe PMC)	0.40	BioGRID, IntAct
LGALS8	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
LIMA1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
LINC01139	Affinity Capture-RNA, Protein-RNA	physical	26751287, (Europe PMC)	NA	BioGRID
LMBR1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
LMNA	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
LOC400499	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
LONP1	Affinity Capture-MS	physical	24797263, 28065597, (Europe PMC)	NA	BioGRID
LRIG1	Affinity Capture-Western	physical	15282549, 15345710, 18542056, (Europe PMC)	NA	BioGRID
LRIG2	Affinity Capture-Western	physical	25353163, (Europe PMC)	NA	BioGRID
LRP1	Affinity Capture-MS, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, 28065597, (Europe PMC)	0.37	BioGRID, IntAct
LRP8	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
LRPPRC	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
LRRC40	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
LRRK1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
LRRTM4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
LRSAM1	Affinity Capture-Western	physical	15256501, (Europe PMC)	NA	BioGRID
LRWD1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
LSM14A	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
LSR	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
LTK	Affinity Capture-Western, Reconstituted Complex	physical	7650032, (Europe PMC)	NA	BioGRID
LTN1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
LUC7L3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
LYN	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, protein kinase assay, ubiquitin reconstruction	association, phosphorylation reaction, physical, physical association	16799092, 23764002, 23866081, 24658140, 25402006, (Europe PMC)	0.40, 0.54, 0.76	BioGRID, IntAct
MAGED2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MAP1LC3A	Affinity Capture-MS	physical	22963397, (Europe PMC)	NA	BioGRID
MAP2K2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
MAP2K3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
MAP2K4	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
MAP3K12	Affinity Capture-Western, PCA, anti bait coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	20029029, (Europe PMC)	0.48	BioGRID, IntAct
MAP3K14	Affinity Capture-Western	physical	11116146, (Europe PMC)	NA	BioGRID
MAP3K3	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
MAP4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MAP4K1	Co-fractionation, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, 9346925, (Europe PMC)	0.37	BioGRID, IntAct
MAPK14	Biochemical Activity, proximity ligation assay	physical, physical association	23397142, 7535770, (Europe PMC)	0.40	BioGRID, IntAct
MAPK15	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MAPK8	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
MAPK8IP1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
MAPK8IP2	PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
MAPK9	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
MAPT	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
MARS	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
MAS1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MAST1	PCA	physical	20029029, (Europe PMC)	NA	BioGRID
MAST2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MATR3	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
MCM3	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
MCM4	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
MCM6	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
MDH1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
MEGF6	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
MET	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, protein kinase assay, tandem affinity purification	association, phosphorylation reaction, physical, physical association	20624308, 21918175, 23866081, 24189400, 24362532, 26551075, (Europe PMC)	0.80	BioGRID, IntAct
MFAP1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MGARP	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
MGST1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
MICB	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MIER1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MIF	Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down	physical, physical association	26280537, (Europe PMC)	0.59	BioGRID, IntAct
MINOS1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
MIR22HG	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MLXIPL	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MMS19	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
MOB4	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
MON2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
MPC2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
MPV17	Co-fractionation	physical	22939629, (Europe PMC)	NA	BioGRID
MPZL2	Affinity Capture-Western	physical	28065597, (Europe PMC)	NA	BioGRID
MRGPRG-AS1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MRM3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
MRPL10	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
MRPL43	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MRPL9	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
MRTO4	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
MTBP	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MTCO2P1	Affinity Capture-MS	physical	19531499, (Europe PMC)	NA	BioGRID
MTG1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MTMR8	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MTOR	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
MUC1	Affinity Capture-Luminescence, Affinity Capture-Western, Biochemical Activity, Co-localization, PCA, Two-hybrid, anti bait coimmunoprecipitation, coimmunoprecipitation, cross-linking study, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	11278868, 11483589, 16983337, 21258405, 24658140, 25402006, (Europe PMC)	0.77	BioGRID, IntAct, MINT
MUC16	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
MYCBP	Affinity Capture-MS	physical	18271526, (Europe PMC)	NA	BioGRID
MYH9	Affinity Capture-Western	physical	22366308, (Europe PMC)	NA	BioGRID
MYO1B	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
MYO1C	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
MYO1D	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
MYO9A	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
NAA10	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
NABP2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
NADSYN1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
NBEAL2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
NCAM1	Reconstituted Complex	physical	17995934, (Europe PMC)	NA	BioGRID
NCAPG	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
NCAPG2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
NCAPH	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
NCAPH2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
NCDN	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
NCK1	Affinity Capture-Western, PCA, Protein-peptide, Reconstituted Complex, Two-hybrid, coimmunoprecipitation, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	10026169, 1333047, 16273093, 24658140, 25402006, 8662998, 9362449, (Europe PMC)	0.70	BioGRID, IntAct, MINT
NCK2	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Reconstituted Complex, Two-hybrid, ubiquitin reconstruction	physical, physical association	10026169, 24658140, 25402006, 9737977, 9843575, (Europe PMC)	0.37	BioGRID, IntAct
NCL	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical	24780295, 25261371, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
NCLN	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
NDFIP1	Affinity Capture-Western	physical	20534535, (Europe PMC)	NA	BioGRID
NDFIP2	Affinity Capture-Western	physical	20534535, (Europe PMC)	NA	BioGRID
NDN	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
NDUFA9	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
NDUFS1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
NDUFS3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
NEDD4	Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy	colocalization, physical, physical association	19953087, 29455656, (Europe PMC)	0.46	BioGRID, IntAct
NEK8	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
NELL1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
NF1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
NF2	Affinity Capture-Western	physical	25043298, (Europe PMC)	NA	BioGRID
NGLY1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
NLRP10	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
NOL6	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
NOSIP	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
NPHP4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
NPM1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
NR3C1	Affinity Capture-Luminescence, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
NRG1	Affinity Capture-Western, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, 7730382, (Europe PMC)	0.37	BioGRID, IntAct
NSF	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
NSUN2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
NSUN5	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
NT5DC2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
NTHL1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
NTPCR	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
NTRK1	Affinity Capture-MS	physical	25921289, (Europe PMC)	NA	BioGRID
NTRK2	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
NUBP2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
NUCKS1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
NUMB	Protein-peptide	physical	16273093, (Europe PMC)	NA	BioGRID
NUMBL	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
NUP153	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
NUP85	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
NUP93	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
NXF2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
OAT	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
OAZ1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
ODF3L2	Affinity Capture-MS, Affinity Capture-Western	physical	18271526, (Europe PMC)	NA	BioGRID
OLFM1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
OPA1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
OR2F2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
OR2W3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ORC5	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
OS9	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
OSBP	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
OSMR	Affinity Capture-Western	physical	27110918, (Europe PMC)	NA	BioGRID
OTUD7B	Affinity Capture-Western	physical	22179831, (Europe PMC)	NA	BioGRID
OXSR1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
P3H1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
P4HB	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
PAGE3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PAK1	PCA, Two-hybrid	physical	24658140, 25402006, (Europe PMC)	NA	BioGRID
PAK4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PANK4	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PARP1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
PC	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PCDHB11	Affinity Capture-MS	physical	28514442, (Europe PMC)	NA	BioGRID
PCDHGA3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PCNA	Affinity Capture-Western, Biochemical Activity	physical	17115032, (Europe PMC)	NA	BioGRID
PCNX1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PDAP1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PDCD6IP	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	12771190, 15456872, 15557335, 24658140, 25402006, (Europe PMC)	0.57	BioGRID, IntAct, MINT
PDE1C	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PDGFRA	Affinity Capture-Luminescence, PCA, Two-hybrid, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.58	BioGRID, IntAct
PDGFRB	Affinity Capture-Western	physical	9506992, (Europe PMC)	NA	BioGRID
PDIA3	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
PDK1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PDK3	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PDP1	Reconstituted Complex	physical	24486017, (Europe PMC)	NA	BioGRID
PDS5A	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PDXDC1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PELO	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PEX19	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, (Europe PMC)	0.35	BioGRID, IntAct
PFKFB3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PFKL	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
PFKM	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PFKP	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
PGRMC1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PHGDH	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
PHLDA1	Affinity Capture-MS, tandem affinity purification	association, physical	23956138, 24189400, (Europe PMC)	0.35	BioGRID, IntAct
PICALM	Co-fractionation	physical	22939629, (Europe PMC)	NA	BioGRID
PID1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PIGS	Co-fractionation	physical	26344197, (Europe PMC)	NA	BioGRID
PIK3C2B	Affinity Capture-Luminescence, PCA, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, competition binding, luminescence based mammalian interactome mapping, pull down, ubiquitin reconstruction	association, direct interaction, physical, physical association	10805725, 11533253, 24658140, 25402006, (Europe PMC)	0.76	BioGRID, IntAct
PIK3CB	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
PIK3R1	Affinity Capture-MS, Affinity Capture-Western, Co-localization, Protein-peptide, coimmunoprecipitation, competition binding, protein array, proximity ligation assay	association, direct interaction, physical, physical association	16273093, 19531499, 21701776, 25241761, 7797556, 8662998, (Europe PMC)	0.78	BioGRID, IntAct, MINT
PIK3R2	Affinity Capture-MS, PCA, Protein-peptide, Reconstituted Complex, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	1334406, 16273093, 19531499, 23956138, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
PIK3R3	Co-localization, PCA, Protein-peptide, Two-hybrid, protein array, proximity ligation assay, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25241761, 25402006, (Europe PMC)	0.70	BioGRID, IntAct, MINT
PIM1	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
PIN4	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PLAA	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
PLCG1	Affinity Capture-MS, Affinity Capture-Western, Protein-peptide, coimmunoprecipitation, cross-linking study, far western blotting, protein array, pull down	association, direct interaction, physical, physical association	11983899, 12061819, 12803489, 14568990, 16273093, 19605547, 24797263, 7693694, 7993895, 9020117, 9207933, 9756944, (Europe PMC)	0.85	BioGRID, IntAct, MINT
PLCG2	Affinity Capture-Luminescence, Co-localization, PCA, Protein-peptide, Two-hybrid, luminescence based mammalian interactome mapping, protein array, proximity ligation assay, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25241761, 25402006, (Europe PMC)	0.74	BioGRID, IntAct, MINT
PLD2	Affinity Capture-Western	physical	9837959, (Europe PMC)	NA	BioGRID
PLD3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PLEKHA7	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PLK1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PLS3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PLSCR1	Affinity Capture-Western, Co-fractionation	physical	12009895, (Europe PMC)	NA	BioGRID
PLVAP	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PML	Affinity Capture-Western, Co-localization, Reconstituted Complex	physical	23563092, (Europe PMC)	NA	BioGRID
PMM2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PNO1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
POLDIP2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
POLR2A	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PON2	Affinity Capture-MS	physical	24797263, 26186194, 28514442, (Europe PMC)	NA	BioGRID
PPARG	Affinity Capture-Western, Biochemical Activity	physical	26718225, (Europe PMC)	NA	BioGRID
PPARGC1A	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
PPIB	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PPM1A	Affinity Capture-Western, Two-hybrid	physical	28065597, (Europe PMC)	NA	BioGRID
PPM1B	Two-hybrid	physical	28065597, (Europe PMC)	NA	BioGRID
PPM1F	Affinity Capture-Western	physical	28065597, (Europe PMC)	NA	BioGRID
PPP2R1A	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
PPP2R1B	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
PPP2R2A	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
PPP2R3A	Affinity Capture-Western	physical	19825976, (Europe PMC)	NA	BioGRID
PPP2R5C	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PPP2R5E	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
PPP3CB	Two-hybrid	physical	28065597, (Europe PMC)	NA	BioGRID
PPP5C	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PPP6C	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
PPP6R1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
PRCC	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PRDX1	Affinity Capture-MS, PCA, ubiquitin reconstruction	physical, physical association	18271526, 20029029, 23956138, (Europe PMC)	0.37	BioGRID, IntAct
PRICKLE1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PRIM1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PRKAA1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PRKACA	Affinity Capture-Western, Biochemical Activity	physical	12589790, 9050991, (Europe PMC)	NA	BioGRID
PRKAG1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PRKAR1A	Affinity Capture-Western	physical	9050991, (Europe PMC)	NA	BioGRID
PRKAR1B	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PRKCA	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	12878187, 24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
PRKCB	Biochemical Activity	physical	9815893, (Europe PMC)	NA	BioGRID
PRKCE	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
PRKCZ	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
PRKDC	Affinity Capture-MS, proximity ligation assay	physical, physical association	23178489, 23956138, (Europe PMC)	0.40	BioGRID, IntAct
PRKN	Affinity Capture-Western	physical	25877876, (Europe PMC)	NA	BioGRID
PRMT3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PRR14	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PRSS42	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PSMA3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PSMA4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
PSMA7	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PSMD1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PSMD2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
PSMD4	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PSPC1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PTCH1	Affinity Capture-MS	physical	26186194, 28514442, (Europe PMC)	NA	BioGRID
PTEN	Affinity Capture-Western	physical	26531778, (Europe PMC)	NA	BioGRID
PTGDS	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PTGES3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PTK2	Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	10806474, 15657067, 24658140, 25402006, (Europe PMC)	0.55	BioGRID, IntAct
PTK2B	Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical	10777553, 10980697, 15657067, (Europe PMC)	0.35	BioGRID, IntAct
PTK6	Affinity Capture-Western, Protein-peptide, protein array	direct interaction, physical	16273093, 8940083, (Europe PMC)	0.44	BioGRID, IntAct, MINT
PTPN1	Affinity Capture-Luminescence, Biochemical Activity, Co-crystal Structure, PCA, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy, protein kinase assay, ubiquitin reconstruction	colocalization, phosphorylation reaction, physical, physical association	10889023, 24658140, 25402006, 25796184, 7693694, 8621392, 9050838, 9355745, (Europe PMC)	0.82	BioGRID, IntAct, MINT
PTPN11	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Protein-peptide, Two-hybrid, protein array, pull down	direct interaction, physical, physical association	16273093, 16729043, 20473329, 28065597, 7673163, 8959326, 9756944, (Europe PMC)	0.61	BioGRID, IntAct, MINT
PTPN12	Affinity Capture-Luminescence, PCA, Two-hybrid, bimolecular fluorescence complementation, ubiquitin reconstruction	physical, physical association	20029029, 21376233, 24658140, 25402006, 28065597, (Europe PMC)	0.67	BioGRID, IntAct
PTPN18	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
PTPN2	Affinity Capture-Western, genetic interference	genetic interaction, physical	11514572, 15592458, (Europe PMC)	0.17	BioGRID, IntAct, MINT
PTPN20	Affinity Capture-MS, Two-hybrid	physical	28065597, (Europe PMC)	NA	BioGRID
PTPN22	Affinity Capture-Luminescence, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
PTPN23	Affinity Capture-Western	physical	23477725, (Europe PMC)	NA	BioGRID
PTPN6	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, pull down	association, physical	28065597, 7673163, 9733788, (Europe PMC)	0.35	BioGRID, IntAct, MINT
PTPN7	Two-hybrid	physical	28065597, (Europe PMC)	NA	BioGRID
PTPRA	Affinity Capture-Western, Two-hybrid	physical	28065597, (Europe PMC)	NA	BioGRID
PTPRB	Biochemical Activity, Two-hybrid, phosphatase assay	dephosphorylation reaction, physical	19167335, 28065597, 8870675, (Europe PMC)	0.44	BioGRID, IntAct
PTPRD	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
PTPRF	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
PTPRH	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid	physical	28065597, (Europe PMC)	NA	BioGRID
PTPRJ	Affinity Capture-Western, FRET, phosphatase assay	dephosphorylation reaction, physical	19167335, 19836242, (Europe PMC)	0.44	BioGRID, IntAct
PTPRK	Affinity Capture-MS	physical	26186194, 28514442, (Europe PMC)	NA	BioGRID
PTPRR	Two-hybrid	physical	28065597, (Europe PMC)	NA	BioGRID
PTPRT	Affinity Capture-MS, Two-hybrid	physical	28065597, (Europe PMC)	NA	BioGRID
PTPRU	Biochemical Activity	physical	8870675, (Europe PMC)	NA	BioGRID
PUM1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PUS1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
PYCR2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
RAB18	Affinity Capture-MS	physical	24797263, 28065597, (Europe PMC)	NA	BioGRID
RAB1A	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RAB31	Affinity Capture-Western, Reconstituted Complex	physical	19725050, (Europe PMC)	NA	BioGRID
RAB3A	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
RABGEF1	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy	association, colocalization, physical, physical association	16499958, 28065597, (Europe PMC)	0.60	BioGRID, IntAct
RAF1	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
RANBP1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
RANGAP1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
RAP1GDS1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
RAPGEF1	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
RARS	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
RASA1	Protein-peptide, Reconstituted Complex, protein array	direct interaction, physical	1385407, 16273093, 8647858, (Europe PMC)	0.44	BioGRID, IntAct, MINT
RASA4B	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RASGEF1B	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RBM10	Affinity Capture-MS	physical	18271526, 24797263, 28065597, (Europe PMC)	NA	BioGRID
RBM25	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
RBM39	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RBM41	Affinity Capture-MS	physical	18271526, (Europe PMC)	NA	BioGRID
RCC2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RCN2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
REEP4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RER1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
RET	Affinity Capture-Western, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, 28460442, (Europe PMC)	0.37	BioGRID, IntAct
RFC3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
RFC4	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
RFC5	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
RGS16	Affinity Capture-Western, Biochemical Activity	physical	11602604, (Europe PMC)	NA	BioGRID
RGS2	Biochemical Activity	physical	11602604, (Europe PMC)	NA	BioGRID
RGS4	Biochemical Activity, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	11602604, 24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
RIN1	Affinity Capture-Western, anti tag coimmunoprecipitation, confocal microscopy	colocalization, physical, physical association	17403676, (Europe PMC)	0.46	BioGRID, IntAct
RIN2	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
RIOK1	Affinity Capture-MS	physical	18271526, (Europe PMC)	NA	BioGRID
RIOK2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
RIPK1	Affinity Capture-Western	physical	11116146, (Europe PMC)	NA	BioGRID
RLIM	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RNF115	Affinity Capture-Western, Biochemical Activity	physical	23418353, (Europe PMC)	NA	BioGRID
RNF125	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RNF126	Affinity Capture-Western, Biochemical Activity	physical	23418353, (Europe PMC)	NA	BioGRID
RNF213	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
ROBO4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RPA1	Affinity Capture-MS	physical	24332808, (Europe PMC)	NA	BioGRID
RPA2	Affinity Capture-MS	physical	24332808, (Europe PMC)	NA	BioGRID
RPA3	Affinity Capture-MS	physical	24332808, (Europe PMC)	NA	BioGRID
RPF1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RPL14	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RPL17	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
RPL22	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
RPL23	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
RPL3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RPL38	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
RPL4	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
RPL6	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RPL7	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RPLP2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RPN1	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
RPRD1A	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
RPS15	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
RPS15A	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
RPS20	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RPS26P11	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
RPS27	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RPS3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RPS6KA3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
RRAD	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex	physical	25313011, 28065597, (Europe PMC)	NA	BioGRID
RSRC2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RUNDC3B	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RUSC2	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
RUVBL2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
RWDD1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
S100A10	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
S100A4	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
S100A7	Affinity Capture-MS	physical	16799092, (Europe PMC)	NA	BioGRID
S100A9	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
SAAL1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
SAMHD1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SAMM50	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SCAMP3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SCD	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SCFD1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SCGB1D4	Affinity Capture-MS	physical	28514442, (Europe PMC)	NA	BioGRID
SCYL1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SCYL2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SDF2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SDF2L1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SEC13	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
SEC16A	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SEC61A1	Affinity Capture-MS, Affinity Capture-Western	physical	20937808, 23956138, (Europe PMC)	NA	BioGRID
SEC61B	Affinity Capture-Western, Co-fractionation	physical	19602593, 20937808, (Europe PMC)	NA	BioGRID
SEL1L	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
SELENOP	PCA	physical	20029029, (Europe PMC)	NA	BioGRID
SERAC1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
SERBP1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SERPINB12	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SERPINB4	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
SERTAD4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SESN2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SETX	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SFN	Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	15657067, 16799092, 24189400, 24658140, 25402006, (Europe PMC)	0.78	BioGRID, IntAct
SFPQ	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
SFXN3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SGPL1	Affinity Capture-MS	physical	23956138, 24189400, (Europe PMC)	NA	BioGRID
SGSM2	Two-hybrid, two hybrid pooling approach	physical, physical association	16169070, (Europe PMC)	0.37	BioGRID, IntAct
SH2B1	PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
SH2B3	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SH2D1A	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SH2D2A	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SH2D3A	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	10187783, 24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
SH2D3C	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SH3BGRL	Affinity Capture-MS, pull down, ubiquitin reconstruction	physical, physical association	16729043, 20029029, (Europe PMC)	0.57	BioGRID, IntAct, MINT
SH3GL2	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	11894095, 15456872, 24658140, 24854121, 25402006, (Europe PMC)	0.57	BioGRID, IntAct, MINT
SH3GL3	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SH3KBP1	Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical, physical association	11894095, 12177062, 12734385, 12771190, 15456872, 16849543, 21635887, (Europe PMC)	0.62	BioGRID, IntAct, MINT
SHANK2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SHC1	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Protein-peptide, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, competition binding, experimental interaction detection, luminescence based mammalian interactome mapping, protein array, protein kinase assay, pull down, tandem affinity purification, ubiquitin reconstruction, x-ray crystallography	association, direct interaction, phosphorylation reaction, physical, physical association	10049786, 10595738, 10635327, 10766863, 11370743, 11408594, 15657067, 16273093, 16729043, 18271526, 19531499, 20473329, 20935677, 21278788, 23178716, 23799367, 23956138, 24189400, 24430869, 24658140, 24797263, 25402006, 26551075, 28065597, 7506413, 7518560, 7542744, 8034616, 8662998, 8810340, 9130710, 9544989, 9756944, (Europe PMC)	0.58, 0.97	BioGRID, IntAct, MINT
SHC2	Affinity Capture-Western, Protein-peptide, protein array	direct interaction, physical	16273093, 24430869, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SHC3	Affinity Capture-Western, Protein-peptide, Reconstituted Complex, protein array	direct interaction, physical	16273093, 8662772, 9507002, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SHC4	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Reconstituted Complex, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24430869, 24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
SKIV2L	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SLA	PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
SLA2	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SLC12A2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SLC13A5	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SLC1A5	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SLC25A13	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SLC39A11	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
SLC39A7	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SLC3A1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SLC3A2	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	15657067, 16799092, 24189400, 24797263, (Europe PMC)	0.64	BioGRID, IntAct
SLC45A2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SLC45A4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SLC7A5	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
SLCO3A1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SLFN11	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SLITRK3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SMC1A	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SMC2	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
SMC3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SMG1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SMIM5	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SMTNL1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SMURF2	Affinity Capture-Western, Reconstituted Complex	physical	21750651, (Europe PMC)	NA	BioGRID
SNCA	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SNRPA1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SNRPD1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
SNRPD2	Affinity Capture-MS	physical	19531499, (Europe PMC)	NA	BioGRID
SNRPF	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SNX1	Affinity Capture-Western	physical	9819414, (Europe PMC)	NA	BioGRID
SNX2	Affinity Capture-MS, Affinity Capture-Western	physical	24797263, 9819414, (Europe PMC)	NA	BioGRID
SNX29	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SNX4	Affinity Capture-Western	physical	9819414, (Europe PMC)	NA	BioGRID
SNX6	Affinity Capture-Western	physical	11279102, (Europe PMC)	NA	BioGRID
SNX9	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SOCS1	Affinity Capture-Western	physical	12070153, (Europe PMC)	NA	BioGRID
SOCS3	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	12070153, 24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SOCS4	Protein-peptide	physical	17997974, (Europe PMC)	NA	BioGRID
SOCS5	Affinity Capture-Western	physical	15590694, (Europe PMC)	NA	BioGRID
SOCS6	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SORBS2	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
SOS1	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation	physical, physical association	10675333, 18271526, 19289468, 19531499, 20473329, 23956138, 24797263, 26005835, 7510700, 9447973, (Europe PMC)	0.40	BioGRID, IntAct
SOS2	Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	10675333, 18271526, 19531499, 23956138, 24658140, 24797263, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SPAG7	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SPAG8	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SPARCL1	PCA	physical	20029029, (Europe PMC)	NA	BioGRID
SPATC1L	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SPCS2	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
SPEN	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SPINDOC	Affinity Capture-MS	physical	18271526, (Europe PMC)	NA	BioGRID
SPRR1A	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
SPTLC1	Affinity Capture-MS	physical	23956138, 24797263, 28065597, (Europe PMC)	NA	BioGRID
SRC	Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	10358079, 10777553, 10971656, 17158602, 17284441, 20333651, 20624308, 20935677, 21268077, 21278788, 21573184, 23175185, 24189400, 24658140, 25402006, 28065597, (Europe PMC)	0.82	BioGRID, IntAct, MINT
SRPRA	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SRPRB	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SRRM1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SRRM2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SRRM4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SRSF11	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SRSF2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SSB	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SSBP1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SSH1	Affinity Capture-Western	physical	28065597, (Europe PMC)	NA	BioGRID
SSR4	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SSRP1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ST8SIA4	Affinity Capture-MS	physical	28514442, (Europe PMC)	NA	BioGRID
STAM2	Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, confocal microscopy	colocalization, physical, physical association	15212941, 17403676, (Europe PMC)	0.46	BioGRID, IntAct
STAP2	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
STAT1	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, anti tag coimmunoprecipitation, competition binding, electrophoretic mobility shift assay, luminescence based mammalian interactome mapping, ubiquitin reconstruction	association, physical, physical association	10358079, 12070153, 15284024, 23956138, 24658140, 24797263, 25402006, (Europe PMC)	0.71	BioGRID, IntAct, MINT
STAT2	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
STAT3	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-localization, PCA, Two-hybrid	physical	10358079, 15284024, 15485908, 15950906, 18258752, 20145033, 21573184, 23956138, 24135280, 24189400, 24658140, 25241761, 25402006, 9756944, (Europe PMC)	NA	BioGRID
STAT5A	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-localization, PCA, Two-hybrid, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	10358079, 16729043, 22729867, 24135280, 24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
STAT5B	Affinity Capture-Western, Co-localization, pull down	physical, physical association	10558875, 16729043, 22729867, (Europe PMC)	0.40	BioGRID, IntAct, MINT
STIL	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
STIP1	PCA, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.51	BioGRID, IntAct
STK26	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
STOM	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
STPG4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
STRAP	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
STT3A	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
STUB1	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid	physical	20029029, 24658140, 24722501, 25402006, 27475501, (Europe PMC)	NA	BioGRID
STYX	Two-hybrid	physical	28065597, (Europe PMC)	NA	BioGRID
SUB1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SUCLA2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SUGP2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SULT1A1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
SUPT5H	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SUSD1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
SWT1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
SYK	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SYT17	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TAB1	Affinity Capture-MS, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	18271526, 24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
TAF4	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TARS	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TARS2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TBK1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TBL3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TBRG4	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
TCIRG1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TCOF1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TCP1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TECR	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
TEKT2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TELO2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
TFRC	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TGFA	Co-crystal Structure, PCA, Two-hybrid, ubiquitin reconstruction, x-ray crystallography	direct interaction, physical, physical association	12297049, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct
THADA	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
THEM6	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
THOP1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TIMM23	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TIMM50	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
TJP1	Affinity Capture-Western	physical	12708492, (Europe PMC)	NA	BioGRID
TLN1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
TLR2	PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	17126326, 24658140, 25402006, (Europe PMC)	0.57	BioGRID, IntAct, MINT
TM9SF3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TMBIM1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TMCO3	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
TMEM159	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TMEM25	Affinity Capture-MS	physical	26186194, (Europe PMC)	NA	BioGRID
TMEM267	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TMEM97	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TNC	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TNFRSF10B	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TNFRSF1A	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
TNIK	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TNK2	Affinity Capture-MS, Affinity Capture-Western, Co-localization, anti bait coimmunoprecipitation	association, physical	15657067, 17182860, 18271526, 18435854, 19815557, 20086093, 20359967, 24413169, (Europe PMC)	0.35	BioGRID, IntAct
TNPO1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
TNPO2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
TNPO3	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
TNS3	Affinity Capture-Luminescence, PCA, Two-hybrid, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.58	BioGRID, IntAct
TNS4	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
TOM1L1	Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy	colocalization, physical, physical association	19798056, (Europe PMC)	0.56	BioGRID, IntAct, MINT
TOMM22	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TOMM70	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TOP1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
TOPAZ1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TOR1AIP1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TOR4A	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
TP53	Synthetic Growth Defect, Synthetic Lethality	genetic	23284306, 27438146, (Europe PMC)	NA	BioGRID
TPI1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
TPM1	PCA	physical	20029029, (Europe PMC)	NA	BioGRID
TPM3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TPM4	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TPP1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
TRA2B	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TRAF2	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	18271526, 23972990, 24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
TRAF3IP1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TRAFD1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TRAPPC3	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
TRAPPC5	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TRHDE	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TRIM23	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TRIM28	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
TRIML2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TRMT10C	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TRMT1L	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TRMT2A	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TRPM3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TRPV1	Affinity Capture-Western, Reconstituted Complex	physical	19155296, (Europe PMC)	NA	BioGRID
TSG101	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TTC27	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
TTC37	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TTI1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
TTI2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
TTN	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
TUBA1A	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, anti bait coimmunoprecipitation, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	15657067, 16799092, 24189400, 24658140, 25402006, (Europe PMC)	0.66	BioGRID, IntAct
TUBA4A	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	16799092, 23956138, 24189400, (Europe PMC)	0.53	BioGRID, IntAct
TUBB	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, (Europe PMC)	0.35	BioGRID, IntAct
TUBB2A	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
TUBB3	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
TUBB4A	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
TUBB4B	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
TUBB6	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
TUBG1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TUBGCP2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
TUFM	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
TXN	Affinity Capture-Luminescence, PCA, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	15657067, 20029029, 24658140, (Europe PMC)	0.72	BioGRID, IntAct
U2AF2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
UBA2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
UBAP2L	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
UBASH3A	Affinity Capture-Western	physical	15107835, 15159412, (Europe PMC)	NA	BioGRID
UBASH3B	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	15159412, 17880946, 18271526, 23956138, 24189400, 24797263, (Europe PMC)	0.46	BioGRID, IntAct
UBC	Affinity Capture-MS, Affinity Capture-Western	physical	11916981, 19531499, (Europe PMC)	NA	BioGRID
UBE2G2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
UBE2J2	Affinity Capture-Western	physical	29069742, (Europe PMC)	NA	BioGRID
UBE2S	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
UBE2V2	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
UBR4	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
UCHL1	PCA, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.51	BioGRID, IntAct
UCK2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
UFL1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
UMPS	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
UNC80	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
UQCRC2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
UROD	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
USP2	Affinity Capture-Western	physical	22370483, (Europe PMC)	NA	BioGRID
USP31	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
USP34	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
USP8	Affinity Capture-Western, Biochemical Activity	physical	16120644, 23153581, 23333852, 23477725, 25485838, 25853104, (Europe PMC)	NA	BioGRID
USP9X	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
UTP15	Affinity Capture-MS	physical	24797263, 28065597, (Europe PMC)	NA	BioGRID
VAC14	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
VAPA	Affinity Capture-MS, PCA, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	20029029, 23956138, (Europe PMC)	0.51	BioGRID, IntAct
VARS	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
VAV1	Affinity Capture-Western, PCA, Protein-peptide, Two-hybrid, ubiquitin reconstruction	physical, physical association	10938113, 16273093, 24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
VAV2	Affinity Capture-MS, Affinity Capture-Western, pull down	association, physical	10938113, 12454019, 18271526, 19531499, 20940296, 24797263, (Europe PMC)	0.35	BioGRID, IntAct, MINT
VAV3	Affinity Capture-MS, Affinity Capture-Western	physical	10938113, 24797263, (Europe PMC)	NA	BioGRID
VPS13A	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
VPS4B	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
VRK1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
WAS	Affinity Capture-Western	physical	9307968, (Europe PMC)	NA	BioGRID
WASF3	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
WASL	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
WBP2	Affinity Capture-Western	physical	27578003, (Europe PMC)	NA	BioGRID
WDR26	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
WDR6	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
WIPI2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
WWC2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
XIAP	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
XPO1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
XPO4	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
XPO5	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
XPO6	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
XPO7	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
XPOT	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
XRCC5	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
XRN2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	24189400, 24780295, (Europe PMC)	0.53	BioGRID, IntAct
XRRA1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
YAP1	Affinity Capture-Western	physical	12807903, (Europe PMC)	NA	BioGRID
YARS	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
YBEY	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
YBX1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
YES1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical, physical association	15657067, 23866081, 24797263, (Europe PMC)	0.56	BioGRID, IntAct
YTHDF1	Affinity Capture-MS	physical	24189400, (Europe PMC)	NA	BioGRID
YWHAB	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
YWHAQ	PCA, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	15657067, 20029029, 24189400, 24658140, 25402006, (Europe PMC)	0.81	BioGRID, IntAct
YWHAZ	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, anti bait coimmunoprecipitation, filter binding, fluorescence microscopy, ubiquitin reconstruction	association, colocalization, physical, physical association	15225635, 15657067, 19531499, 23956138, 24658140, 25402006, (Europe PMC)	0.70	BioGRID, IntAct
ZAP70	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
ZBTB14	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ZBTB22	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ZC3H4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ZC3HAV1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ZCCHC18	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ZFR	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ZFYVE21	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ZFYVE28	Co-localization	physical	19460345, (Europe PMC)	NA	BioGRID
ZMYM4	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ZNF114	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ZNF516	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ZNF573	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ZW10	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
ZZZ3	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID

Visualize Download

Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
ABL2	PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
ACSL3	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
ACTN4	ubiquitin reconstruction	physical association	24658140, (Europe PMC)	0.37	IntAct
ADRM1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
AGER	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	physical association	16954185, (Europe PMC)	0.52	IntAct
AGO2	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, bimolecular fluorescence complementation, protein kinase assay, pull down	association, direct interaction, phosphorylation reaction, physical association	23636329, (Europe PMC)	0.68	IntAct
AHNAK	Affinity Capture-MS, PCA, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	20029029, 24189400, (Europe PMC)	0.55	BioGRID, IntAct
AHSA1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
AIP	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
AKAP12	PCA, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.51	BioGRID, IntAct
AKT1	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
ALCAM	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
ALDOA	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
ANKS1A	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, anti tag coimmunoprecipitation, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.66	BioGRID, IntAct, MINT
ANKS1B	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
ANO5	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
ANXA1	Affinity Capture-MS, anti tag coimmunoprecipitation, imaging technique, tandem affinity purification, ubiquitin reconstruction	association, colocalization, physical, physical association	15581623, 20029029, 24189400, (Europe PMC)	0.70	BioGRID, IntAct, MINT
ANXA2	anti bait coimmunoprecipitation, confocal microscopy	colocalization, physical association	25136068, (Europe PMC)	0.46	IntAct
AOPEP	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
AP1B1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
AP2A1	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	20029029, 23956138, 24189400, 24797263, (Europe PMC)	0.53	BioGRID, IntAct
AP2A2	Affinity Capture-MS, tandem affinity purification	association, physical	23956138, 24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
AP2B1	Affinity Capture-MS, tandem affinity purification	association, physical	23956138, 24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
AP2M1	Affinity Capture-MS, PCA, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	20029029, 23956138, 24189400, 24797263, (Europe PMC)	0.55	BioGRID, IntAct
AP2S1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
APBA3	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
APBB1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
APBB2	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, luminescence based mammalian interactome mapping, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.66	BioGRID, IntAct, MINT
APBB3	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
APEX1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
APOB	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
APP	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
APPL1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
ARF6	ubiquitin reconstruction	physical association	20029029, (Europe PMC)	0.37	IntAct
ARHGEF7	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
ARMC8	Affinity Capture-MS, tandem affinity purification	association, physical	23956138, 24189400, (Europe PMC)	0.35	BioGRID, IntAct
ARPC5	ubiquitin reconstruction	physical association	20029029, (Europe PMC)	0.37	IntAct
ARRB1	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
ARRB2	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
ATIC	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
ATP1A1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, 24797263, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
ATP1B1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
ATP2A2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	15657067, 23956138, 24189400, (Europe PMC)	0.53	BioGRID, IntAct
ATP2B4	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
ATP5F1A	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
ATP5F1B	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
ATP5F1C	two hybrid pooling approach	physical association	16169070, (Europe PMC)	0.37	IntAct
ATXN10	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, (Europe PMC)	0.35	BioGRID, IntAct
AURKA	anti tag coimmunoprecipitation, protein array, proximity ligation assay	direct interaction, physical association	23520446, (Europe PMC)	0.60	IntAct
AXL	anti bait coimmunoprecipitation, proximity ligation assay	physical association	25873175, (Europe PMC)	0.52	IntAct
BABAM2	anti bait coimmunoprecipitation	association	24780295, (Europe PMC)	0.35	IntAct
BAIAP2	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	24189400, 24658140, 25402006, (Europe PMC)	0.55	BioGRID, IntAct
BCAR1	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
BCAR3	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
BECN1	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy	association, colocalization, physical association	24034250, (Europe PMC)	0.63	IntAct
BLK	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
BMX	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
CAMLG	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	12919676, 24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
CANX	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
CAPN7	fluorescence microscopy	colocalization	24953135, (Europe PMC)	0.27	IntAct, MINT
CAV1	Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, PCA, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	10781609, 12388423, 15273741, 15657067, 16407214, 16799092, 19446582, 22411794, 24658140, 25402006, 9374534, (Europe PMC)	0.75	BioGRID, IntAct
CAV2	Affinity Capture-MS, PCA, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	15273741, 16799092, 24658140, 25402006, (Europe PMC)	0.55	BioGRID, IntAct
CAVIN1	anti bait coimmunoprecipitation	association	18776048, (Europe PMC)	0.35	IntAct
CBL	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, far western blotting, fluorescence microscopy, isothermal titration calorimetry, pull down, x-ray crystallography	association, colocalization, direct interaction, physical, physical association	10086340, 10428778, 10635327, 11239464, 11370743, 11408594, 12061819, 12593795, 12604776, 12734385, 12803489, 14505571, 14627991, 15107835, 15117950, 15159412, 15210722, 15282549, 15383614, 15465819, 15657067, 15668240, 15677445, 15735736, 15962011, 16105874, 16246327, 16729043, 16849543, 16914641, 16923119, 16969069, 17182860, 17242169, 17486068, 17545148, 17880946, 17971399, 17995934, 18271526, 18273061, 18316398, 18508924, 19155296, 19225046, 19531499, 19578043, 19713535, 19836242, 19947936, 20124286, 20308550, 20562913, 20877636, 20940296, 21772844, 22203672, 22266821, 22394513, 22591401, 22833562, 22976291, 23153581, 23158001, 23175185, 23418353, 23457600, 23774213, 23799367, 23897813, 24714105, 24797263, 25140053, 25521828, 25872741, 26055326, 26177020, 27059931, 28198003, 28791635, 7592693, 7657591, 7782294, 8662998, 9121472, 9130710, 9756944, (Europe PMC)	0.96	BioGRID, IntAct, MINT
CBLB	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation	association, physical	10086340, 10635327, 11375397, 15657067, 16702950, 16729043, 18271526, 19531499, 20308550, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
CBR1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
CCAR2	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
CD59	FRET, fluorescent resonance energy transfer	direct interaction, physical	12577067, (Europe PMC)	0.44	BioGRID, IntAct
CDC25C	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
CDC37	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, luminescence based mammalian interactome mapping, tandem affinity purification	association, physical, physical association	12471035, 23956138, 24189400, 25036637, (Europe PMC)	0.62	BioGRID, IntAct
CDCP1	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
CDH1	Affinity Capture-MS, Affinity Capture-Western, Co-localization, PCA, Proximity Label-MS, Two-hybrid, proximity ligation assay, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	10969083, 24189400, 24658140, 25241761, 25402006, 25468996, (Europe PMC)	0.68	BioGRID, IntAct
CDK1	Affinity Capture-MS, PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	15657067, 18271526, 23956138, 24658140, 25402006, (Europe PMC)	0.55	BioGRID, IntAct
CEND1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
CFL1	PCA, ubiquitin reconstruction	physical, physical association	20029029, 24658140, (Europe PMC)	0.55	BioGRID, IntAct
CHD5	ubiquitin reconstruction	physical association	24658140, (Europe PMC)	0.37	IntAct
CHIA	anti bait coimmunoprecipitation	physical association	18824549, (Europe PMC)	0.40	IntAct
CISH	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, luminescence based mammalian interactome mapping, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.66	BioGRID, IntAct, MINT
CKAP4	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
CLNK	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
CLTA	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
CLTCL1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
CMTM8	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy	colocalization, physical association	16263120, (Europe PMC)	0.56	IntAct, MINT
CNTN2	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
COL17A1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
COL9A3	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
CRK	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, PCA, Protein-peptide, Two-hybrid, luminescence based mammalian interactome mapping, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	10595738, 16273093, 16729043, 24658140, 25402006, 9617486, 9642287, (Europe PMC)	0.51, 0.59	BioGRID, IntAct, MINT
CRKL	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, proximity ligation assay, pull down, ubiquitin reconstruction	physical, physical association	16729043, 18271526, 23397142, 24658140, 25402006, (Europe PMC)	0.69	BioGRID, IntAct, MINT
CSE1L	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
CSK	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, pull down, ubiquitin reconstruction	physical, physical association	16729043, 24658140, 24797263, 25402006, (Europe PMC)	0.57	BioGRID, IntAct, MINT
CSRP1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
CSTA	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
CTNNA1	Affinity Capture-MS, Co-localization, anti bait coimmunoprecipitation, proximity ligation assay, tandem affinity purification	association, physical, physical association	15657067, 24189400, 25241761, (Europe PMC)	0.67	BioGRID, IntAct
CTNNA2	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
CTNNB1	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, tandem affinity purification	association, physical	11950845, 24189400, 9233779, 9535896, (Europe PMC)	0.35	BioGRID, IntAct
CTNND1	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	15657067, 24189400, 24658140, 24797263, 25402006, 27316454, 9535896, (Europe PMC)	0.66	BioGRID, IntAct
CTTN	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	24658140, 24797263, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
CYLC2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
DBR1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
DCTN2	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
DHX9	anti bait coimmunoprecipitation	association	24780295, (Europe PMC)	0.35	IntAct
DNAJA1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
DNAJA2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	15657067, 23956138, 24189400, 24797263, (Europe PMC)	0.53	BioGRID, IntAct
DNAJA3	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical	15657067, 23698466, 23956138, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
DNAJB11	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
DNAJC13	Affinity Capture-MS, fluorescence microscopy	colocalization, physical	21510942, 28065597, (Europe PMC)	0.27	BioGRID, IntAct, MINT
DNAJC4	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
DOK1	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
DOK4	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
DOK5	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
DOK6	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
DYNC1H1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
EBI-4399559	anti bait coimmunoprecipitation	association, physical association	20308550, (Europe PMC)	0.50	IntAct
EEA1	fluorescence microscopy	colocalization	22971756, 24597955, (Europe PMC)	0.43	IntAct, MINT
EEF1A1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, (Europe PMC)	0.35	BioGRID, IntAct
EEF1G	Affinity Capture-MS, PCA, ubiquitin reconstruction	physical, physical association	20029029, 28065597, (Europe PMC)	0.37	BioGRID, IntAct
EFNB1	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
EGF	Affinity Capture-Luminescence, Affinity Capture-MS, Co-crystal Structure, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, fluorescence-activated cell sorting, molecular sieving, proximity ligation assay, saturation binding, scintillation proximity assay, surface plasmon resonance, transmission electron microscopy, x ray scattering, x-ray crystallography	direct interaction, physical, physical association	10085134, 12093292, 12297050, 12620237, 17697999, 18271526, 19531499, 21439278, 21822280, 22729867, 23597562, 25080504, 25241761, 25453753, 26280537, 2790960, (Europe PMC)	0.96	BioGRID, IntAct, MINT
EGFR	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-purification, FRET, PCA, Reconstituted Complex, anti tag coimmunoprecipitation, beta galactosidase complementation, comigration in non denaturing gel electrophoresis, fluorescence correlation spectroscopy, fluorescence microscopy, fluorescent resonance energy transfer, light scattering, nuclear magnetic resonance, phosphotransferase assay, protein cross-linking with a bifunctional reagent, protein kinase assay, proximity ligation assay, ubiquitin reconstruction, x-ray crystallography	colocalization, direct interaction, phosphorylation reaction, phosphotransfer reaction, physical, physical association	11087732, 12297049, 12297050, 12620237, 14576349, 16777603, 17148612, 18042729, 18271526, 19225046, 19560417, 19563760, 19650109, 20007378, 20029029, 20359299, 20456371, 21278786, 21480528, 21482778, 21775422, 22232519, 22579287, 23273428, 23374349, 23436906, 23595626, 23636329, 23794705, 23956138, 23972990, 24077285, 24135280, 24797263, 25453753, 2732223, 28065597, 2915986, 6321473, 8870675, 9092812, (Europe PMC)	0.98	BioGRID, IntAct
EIF2B3	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
ENGASE	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
EPHA2	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
EPHB4	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
EPS15	Affinity Capture-Western, Co-localization, anti bait coimmunoprecipitation	association, physical	15701692, 16429130, 16499958, 19109251, 21226813, 9049247, (Europe PMC)	0.35	BioGRID, IntAct
EPS8	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	11408594, 24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
ERBB2	Affinity Capture-MS, Affinity Capture-Western, Co-localization, anti bait coimmunoprecipitation, beta galactosidase complementation, protein cross-linking with a bifunctional reagent, protein kinase assay, proximity ligation assay, pull down, tandem affinity purification	association, physical, physical association	10572067, 11408594, 15657067, 16207817, 16516204, 16843263, 17148612, 17307140, 17486068, 18803307, 19060928, 19650109, 20211985, 21044682, 21203579, 21278786, 23436906, 23866081, 24189400, 24557338, 25241761, (Europe PMC)	0.96	BioGRID, IntAct, MINT
ERBB3	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, beta galactosidase complementation, protein cross-linking with a bifunctional reagent, proximity ligation assay, tandem affinity purification	association, physical, physical association	10527633, 10572067, 17148612, 18803307, 21278786, 22439932, 23436906, 23866081, 24189400, (Europe PMC)	0.92	BioGRID, IntAct
ERBB4	Affinity Capture-Western, FRET, anti bait coimmunoprecipitation	physical, physical association	10572067, 23153581, 25140053, (Europe PMC)	0.40	BioGRID, IntAct
ERCC1	Affinity Capture-MS, Affinity Capture-Western, Co-localization, anti bait coimmunoprecipitation, confocal microscopy, proximity ligation assay	association, colocalization, physical, physical association	24780295, (Europe PMC)	0.60	BioGRID, IntAct
ERCC2	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
ERCC4	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
ERRFI1	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, anti bait coimmunoprecipitation, classical fluorescence spectroscopy, tandem affinity purification, x-ray crystallography	association, direct interaction, physical	18046415, 18271526, 18776048, 19531499, 19815557, 23273428, 23956138, 24189400, 24797263, 26280531, 28065597, (Europe PMC)	0.83	BioGRID, IntAct
ESR1	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	physical, physical association	17284441, 20935677, 28065597, (Europe PMC)	0.40, 0.52	BioGRID, IntAct, MINT
EXOC2	anti bait coimmunoprecipitation	physical association	25594178, (Europe PMC)	0.40	IntAct
EXOC3	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	23956138, 25594178, (Europe PMC)	0.40	BioGRID, IntAct
EXOC4	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical, physical association	23956138, 25594178, (Europe PMC)	0.50	BioGRID, IntAct
EXOC7	Affinity Capture-MS, anti bait coimmunoprecipitation, fluorescence microscopy	colocalization, physical, physical association	23956138, 25594178, (Europe PMC)	0.46	BioGRID, IntAct
EXOC8	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	23956138, 25594178, (Europe PMC)	0.40	BioGRID, IntAct
EZR	PCA, ubiquitin reconstruction	physical, physical association	24658140, (Europe PMC)	0.37	BioGRID, IntAct
FABP5	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
FAH	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
FANCC	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
FEN1	anti bait coimmunoprecipitation	association	24780295, (Europe PMC)	0.35	IntAct
FES	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
FGR	Affinity Capture-Luminescence, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
FHL2	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
FKBP4	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
FKBP5	luminescence based mammalian interactome mapping	physical association	25036637, (Europe PMC)	0.40	IntAct
FKBP8	PCA, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.58	BioGRID, IntAct
FN1	PCA, anti tag coimmunoprecipitation	physical, physical association	20029029, (Europe PMC)	0.40	BioGRID, IntAct
FOS	Co-localization, proximity ligation assay	physical, physical association	25241761, (Europe PMC)	0.40	BioGRID, IntAct
FRAT2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
FRK	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
FUS	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
GAB1	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	11432805, 18271526, 21278788, 23066441, 24658140, 25402006, 9890893, (Europe PMC)	0.55	BioGRID, IntAct
GAB2	anti tag coimmunoprecipitation	association	16253990, 19172738, (Europe PMC)	0.53	IntAct, MINT
GABARAPL2	PCA, pull down, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.51	BioGRID, IntAct
GAPDH	Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	16799092, 20029029, 23956138, 24658140, 25402006, (Europe PMC)	0.72	BioGRID, IntAct
GGCT	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
GOLM1	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy, pull down	association, colocalization, direct interaction, physical association	27569582, (Europe PMC)	0.64	IntAct
GOT1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
GPM6B	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
GPNMB	Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down	direct interaction, physical, physical association	26751287, (Europe PMC)	0.52, 0.54	BioGRID, IntAct
GPS1	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
GRAP2	Affinity Capture-Luminescence, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
GRB10	PCA, Reconstituted Complex, Two-hybrid, pull down, two hybrid, ubiquitin reconstruction	direct interaction, physical, physical association	24658140, 25402006, 9506989, (Europe PMC)	0.65	BioGRID, IntAct, MINT
GRB2	Affinity Capture-MS, Affinity Capture-Western, PCA, Protein-peptide, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, competition binding, protein array, pull down, surface plasmon resonance, tandem affinity purification, ubiquitin reconstruction	association, direct interaction, physical, physical association	10026169, 10085134, 10229072, 10595738, 11370743, 11408594, 11896612, 11960376, 12577067, 1322798, 14679214, 15657067, 16273093, 16729043, 16799092, 17242169, 17971399, 18271526, 19254954, 19289468, 19531499, 19836242, 20124286, 20473329, 21278786, 21278788, 21596750, 21706016, 23178716, 23799367, 23956138, 24189400, 24658140, 24797263, 25402006, 27059931, 7506413, 7510700, 7518560, 7527043, 7592693, 7650032, 8647858, 8662998, 8810340, 8887653, 8940013, 9020117, 9050991, 9416834, 9886492, (Europe PMC)	0.98	BioGRID, IntAct, MINT
GRK2	anti tag coimmunoprecipitation, imaging technique	colocalization, physical association	15620700, (Europe PMC)	0.46	IntAct, MINT
GSN	ubiquitin reconstruction	physical association	20029029, (Europe PMC)	0.37	IntAct
GSTT1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
H1FX	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
HCK	PCA, Two-hybrid, proximity ligation assay, ubiquitin reconstruction	physical, physical association	23397142, 24658140, 25402006, (Europe PMC)	0.57	BioGRID, IntAct
HDAC6	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay, ubiquitin reconstruction	association, phosphorylation reaction, physical, physical association	20029029, 20133936, 24658140, 25402006, (Europe PMC)	0.75	BioGRID, IntAct
HDAC7	Affinity Capture-Luminescence, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
HEMGN	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
HEXIM1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
HGS	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation	physical, physical association	15212941, 18508924, 20308550, 23153581, 23477725, 23602387, 25588945, (Europe PMC)	0.40	BioGRID, IntAct
HIST1H1E	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
HIST1H2AA	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
HIST1H2BC	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
HIST1H3A	fluorescence microscopy	colocalization	12577067, (Europe PMC)	0.27	IntAct
HIST1H4A	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
HLA-A	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
HNRNPF	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
HNRNPH1	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	15657067, 18271526, 24189400, (Europe PMC)	0.53	BioGRID, IntAct
HNRNPK	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
HOXC10	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
HSP90AA1	Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	12006493, 12471035, 16024644, 16849543, 20029029, 23956138, 24189400, 24658140, 25402006, (Europe PMC)	0.67	BioGRID, IntAct
HSP90AB1	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	12471035, 15657067, 20029029, 22939624, 23956138, 24189400, 24658140, 25402006, (Europe PMC)	0.84	BioGRID, IntAct
HSP90B1	Affinity Capture-MS, PCA, ubiquitin reconstruction	physical, physical association	12471035, 20029029, 28065597, (Europe PMC)	0.37	BioGRID, IntAct
HSPA1L	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
HSPA2	Affinity Capture-MS, tandem affinity purification	association, physical	23956138, 24189400, (Europe PMC)	0.35	BioGRID, IntAct
HSPA4	Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	12006493, 18271526, 20029029, 24658140, 25402006, (Europe PMC)	0.55	BioGRID, IntAct
HSPA5	anti bait coimmunoprecipitation, tandem affinity purification	association	15657067, 24189400, (Europe PMC)	0.53	IntAct
HSPA8	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, anti bait coimmunoprecipitation, luminescence based mammalian interactome mapping, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	12471035, 15657067, 20029029, 23956138, 24189400, 24658140, 25402006, 28065597, (Europe PMC)	0.72	BioGRID, IntAct
HSPA9	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	15657067, 20029029, 24189400, 28065597, (Europe PMC)	0.66	BioGRID, IntAct
HSPB1	Affinity Capture-MS, anti bait coimmunoprecipitation, proximity ligation assay, tandem affinity purification	association, physical, physical association	15657067, 23397142, 24189400, (Europe PMC)	0.67	BioGRID, IntAct
HSPD1	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
ICAM1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
IGFBP3	anti bait coimmunoprecipitation, proximity ligation assay	association, physical association	23178489, (Europe PMC)	0.58	IntAct
IKBKG	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
ILF2	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
ILF3	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
ILVBL	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
IQGAP1	Affinity Capture-Western, anti bait coimmunoprecipitation, confocal microscopy, pull down	colocalization, direct interaction, physical, physical association	19114553, 21349850, (Europe PMC)	0.63	BioGRID, IntAct
IRS1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
IRS4	Affinity Capture-MS, Protein-peptide, protein array	direct interaction, physical	16273093, 24797263, (Europe PMC)	0.44	BioGRID, IntAct, MINT
ITGB2	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
ITGB4	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
ITK	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
ITSN2	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
JAK2	Affinity Capture-Western, Biochemical Activity, Protein-peptide, protein array	direct interaction, physical	10358079, 16273093, 23838182, (Europe PMC)	0.44	BioGRID, IntAct, MINT
JUP	Affinity Capture-MS, PCA, Reconstituted Complex, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 24797263, 25402006, 9535896, (Europe PMC)	0.37	BioGRID, IntAct
KCTD9	ubiquitin reconstruction	physical association	20029029, (Europe PMC)	0.37	IntAct
KPNA1	anti bait coimmunoprecipitation	physical association	20692258, (Europe PMC)	0.40	IntAct, MINT
KPNB1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
KRT1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
KRT14	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
KRT17	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
KRT5	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
KRT6A	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
LAMP1	fluorescence microscopy	colocalization	21510942, 24597955, (Europe PMC)	0.43	IntAct, MINT
LAPTM4B	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy	association, colocalization, physical association	25594178, (Europe PMC)	0.60	IntAct
LAT	Affinity Capture-Luminescence, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
LCP2	Affinity Capture-Luminescence, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
LGALS3	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation	physical, physical association	19225046, 21258405, 23956138, (Europe PMC)	0.40	BioGRID, IntAct
LINGO1	anti bait coimmunoprecipitation	physical association	17726113, (Europe PMC)	0.40	IntAct
LMNA	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
LRP1	Affinity Capture-MS, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, 28065597, (Europe PMC)	0.37	BioGRID, IntAct
LRRC59	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
LRRK1	anti tag coimmunoprecipitation, protein array	direct interaction, physical association	24947832, (Europe PMC)	0.54	IntAct
LYN	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, protein kinase assay, ubiquitin reconstruction	association, phosphorylation reaction, physical, physical association	16799092, 23764002, 23866081, 24658140, 25402006, (Europe PMC)	0.40, 0.54, 0.76	BioGRID, IntAct
MAP3K12	Affinity Capture-Western, PCA, anti bait coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	20029029, (Europe PMC)	0.48	BioGRID, IntAct
MAP3K3	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
MAP4K1	Co-fractionation, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, 9346925, (Europe PMC)	0.37	BioGRID, IntAct
MAPK14	Biochemical Activity, proximity ligation assay	physical, physical association	23397142, 7535770, (Europe PMC)	0.40	BioGRID, IntAct
MAPK8	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
MAPK8IP1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
MAPK8IP2	PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
MAPK9	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
MAPKAPK3	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
MAPT	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
MAST1	anti tag coimmunoprecipitation, ubiquitin reconstruction	physical association	20029029, (Europe PMC)	0.51	IntAct
MATR3	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
MCM3	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
MCM4	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
MCM5	anti bait coimmunoprecipitation	association	23764002, (Europe PMC)	0.35	IntAct
MCM6	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
MCM7	anti bait coimmunoprecipitation	association	23764002, (Europe PMC)	0.35	IntAct
MDH1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
MEGF6	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
MET	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, protein kinase assay, tandem affinity purification	association, phosphorylation reaction, physical, physical association	20624308, 21918175, 23866081, 24189400, 24362532, 26551075, (Europe PMC)	0.80	BioGRID, IntAct
MGARP	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
MIF	Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down	physical, physical association	26280537, (Europe PMC)	0.59	BioGRID, IntAct
MMP14	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
MOB4	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
MUC1	Affinity Capture-Luminescence, Affinity Capture-Western, Biochemical Activity, Co-localization, PCA, Two-hybrid, anti bait coimmunoprecipitation, coimmunoprecipitation, cross-linking study, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	11278868, 11483589, 16983337, 21258405, 24658140, 25402006, (Europe PMC)	0.77	BioGRID, IntAct, MINT
NANS	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
NCK1	Affinity Capture-Western, PCA, Protein-peptide, Reconstituted Complex, Two-hybrid, coimmunoprecipitation, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	10026169, 1333047, 16273093, 24658140, 25402006, 8662998, 9362449, (Europe PMC)	0.70	BioGRID, IntAct, MINT
NCK2	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Reconstituted Complex, Two-hybrid, ubiquitin reconstruction	physical, physical association	10026169, 24658140, 25402006, 9737977, 9843575, (Europe PMC)	0.37	BioGRID, IntAct
NCL	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical	24780295, 25261371, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
NDN	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
NDUFA4	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
NEDD4	Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy	colocalization, physical, physical association	19953087, 29455656, (Europe PMC)	0.46	BioGRID, IntAct
NELL1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
NPM1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
NQO2	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
NR3C1	Affinity Capture-Luminescence, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
NRG1	Affinity Capture-Western, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, 7730382, (Europe PMC)	0.37	BioGRID, IntAct
NTRK2	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
NUDCD3	luminescence based mammalian interactome mapping	physical association	25036637, (Europe PMC)	0.40	IntAct
NUMB	protein array	direct interaction	16273093, (Europe PMC)	0.44	IntAct, MINT
NUMBL	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
OAZ1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
OLFM1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PAG1	anti bait coimmunoprecipitation	physical association	23866081, (Europe PMC)	0.40	IntAct
PAK1	ubiquitin reconstruction	physical association	24658140, (Europe PMC)	0.37	IntAct
PARP1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
PDCD6IP	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	12771190, 15456872, 15557335, 24658140, 25402006, (Europe PMC)	0.57	BioGRID, IntAct, MINT
PDGFRA	Affinity Capture-Luminescence, PCA, Two-hybrid, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.58	BioGRID, IntAct
PDK3	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PEX19	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, (Europe PMC)	0.35	BioGRID, IntAct
PHLDA1	Affinity Capture-MS, tandem affinity purification	association, physical	23956138, 24189400, (Europe PMC)	0.35	BioGRID, IntAct
PIK3C2A	anti bait coimmunoprecipitation	association	10805725, (Europe PMC)	0.35	IntAct
PIK3C2B	Affinity Capture-Luminescence, PCA, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, competition binding, luminescence based mammalian interactome mapping, pull down, ubiquitin reconstruction	association, direct interaction, physical, physical association	10805725, 11533253, 24658140, 25402006, (Europe PMC)	0.76	BioGRID, IntAct
PIK3R1	Affinity Capture-MS, Affinity Capture-Western, Co-localization, Protein-peptide, coimmunoprecipitation, competition binding, protein array, proximity ligation assay	association, direct interaction, physical, physical association	16273093, 19531499, 21701776, 25241761, 7797556, 8662998, (Europe PMC)	0.78	BioGRID, IntAct, MINT
PIK3R2	Affinity Capture-MS, PCA, Protein-peptide, Reconstituted Complex, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	1334406, 16273093, 19531499, 23956138, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
PIK3R3	Co-localization, PCA, Protein-peptide, Two-hybrid, protein array, proximity ligation assay, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25241761, 25402006, (Europe PMC)	0.70	BioGRID, IntAct, MINT
PIM1	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
PIN4	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PKM	protein kinase assay	phosphorylation reaction	24606918, (Europe PMC)	0.44	IntAct
PKP2	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
PLCG1	Affinity Capture-MS, Affinity Capture-Western, Protein-peptide, coimmunoprecipitation, cross-linking study, far western blotting, protein array, pull down	association, direct interaction, physical, physical association	11983899, 12061819, 12803489, 14568990, 16273093, 19605547, 24797263, 7693694, 7993895, 9020117, 9207933, 9756944, (Europe PMC)	0.85	BioGRID, IntAct, MINT
PLCG2	Affinity Capture-Luminescence, Co-localization, PCA, Protein-peptide, Two-hybrid, luminescence based mammalian interactome mapping, protein array, proximity ligation assay, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25241761, 25402006, (Europe PMC)	0.74	BioGRID, IntAct, MINT
PLCH1	ubiquitin reconstruction	physical association	20029029, (Europe PMC)	0.37	IntAct
PNPLA2	ubiquitin reconstruction	physical association	20029029, (Europe PMC)	0.37	IntAct
PPP2CB	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
PPP5C	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PRCC	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PRDX1	Affinity Capture-MS, PCA, ubiquitin reconstruction	physical, physical association	18271526, 20029029, 23956138, (Europe PMC)	0.37	BioGRID, IntAct
PRKAR1B	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PRKCA	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	12878187, 24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
PRKCE	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
PRKCZ	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
PRKDC	Affinity Capture-MS, proximity ligation assay	physical, physical association	23178489, 23956138, (Europe PMC)	0.40	BioGRID, IntAct
PSMA7	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PSMD4	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PTGDS	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
PTK2	Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	10806474, 15657067, 24658140, 25402006, (Europe PMC)	0.55	BioGRID, IntAct
PTK2B	Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical	10777553, 10980697, 15657067, (Europe PMC)	0.35	BioGRID, IntAct
PTK6	Affinity Capture-Western, Protein-peptide, protein array	direct interaction, physical	16273093, 8940083, (Europe PMC)	0.44	BioGRID, IntAct, MINT
PTPN1	Affinity Capture-Luminescence, Biochemical Activity, Co-crystal Structure, PCA, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy, protein kinase assay, ubiquitin reconstruction	colocalization, phosphorylation reaction, physical, physical association	10889023, 24658140, 25402006, 25796184, 7693694, 8621392, 9050838, 9355745, (Europe PMC)	0.82	BioGRID, IntAct, MINT
PTPN11	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Protein-peptide, Two-hybrid, protein array, pull down	direct interaction, physical, physical association	16273093, 16729043, 20473329, 28065597, 7673163, 8959326, 9756944, (Europe PMC)	0.61	BioGRID, IntAct, MINT
PTPN12	Affinity Capture-Luminescence, PCA, Two-hybrid, bimolecular fluorescence complementation, ubiquitin reconstruction	physical, physical association	20029029, 21376233, 24658140, 25402006, 28065597, (Europe PMC)	0.67	BioGRID, IntAct
PTPN18	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
PTPN2	Affinity Capture-Western, genetic interference	genetic interaction, physical	11514572, 15592458, (Europe PMC)	0.17	BioGRID, IntAct, MINT
PTPN22	Affinity Capture-Luminescence, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
PTPN6	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, pull down	association, physical	28065597, 7673163, 9733788, (Europe PMC)	0.35	BioGRID, IntAct, MINT
PTPRB	Biochemical Activity, Two-hybrid, phosphatase assay	dephosphorylation reaction, physical	19167335, 28065597, 8870675, (Europe PMC)	0.44	BioGRID, IntAct
PTPRC	phosphatase assay	dephosphorylation reaction	19167335, (Europe PMC)	0.44	IntAct
PTPRD	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
PTPRF	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
PTPRG	anti bait coimmunoprecipitation	physical association	25970784, (Europe PMC)	0.40	IntAct
PTPRJ	Affinity Capture-Western, FRET, phosphatase assay	dephosphorylation reaction, physical	19167335, 19836242, (Europe PMC)	0.44	BioGRID, IntAct
PXN	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
RAB11A	anti bait coimmunoprecipitation	physical association	27569582, (Europe PMC)	0.40	IntAct
RAB3A	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
RAB7A	anti bait coimmunoprecipitation	association	18776048, (Europe PMC)	0.35	IntAct
RABGEF1	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy	association, colocalization, physical, physical association	16499958, 28065597, (Europe PMC)	0.60	BioGRID, IntAct
RACK1	anti bait coimmunoprecipitation	physical association	23866081, (Europe PMC)	0.40	IntAct
RAF1	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
RAP1GDS1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
RAPGEF1	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
RAPH1	anti bait coimmunoprecipitation	physical association	24076656, (Europe PMC)	0.40	IntAct, MINT
RASA1	Protein-peptide, Reconstituted Complex, protein array	direct interaction, physical	1385407, 16273093, 8647858, (Europe PMC)	0.44	BioGRID, IntAct, MINT
RBM25	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
RET	Affinity Capture-Western, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, 28460442, (Europe PMC)	0.37	BioGRID, IntAct
RGS4	Biochemical Activity, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	11602604, 24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
RIN1	Affinity Capture-Western, anti tag coimmunoprecipitation, confocal microscopy	colocalization, physical, physical association	17403676, (Europe PMC)	0.46	BioGRID, IntAct
RIN2	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
ROR1	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association, physical association	22439932, (Europe PMC)	0.58	IntAct
RPL17	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
RPS15	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
RPS18	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
RPS26P11	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
RPS4X	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
RUBCN	anti bait coimmunoprecipitation	association, physical association	24034250, 25594178, (Europe PMC)	0.56	IntAct
RUSC2	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
S100A11	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
S100A4	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
S100A9	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
SEC13	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
SELENOP {ECO:0000303\|PubMed:27645994,	ubiquitin reconstruction	physical association	20029029, (Europe PMC)	0.37	IntAct
SERAC1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
SERPINB4	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
SFN	Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	15657067, 16799092, 24189400, 24658140, 25402006, (Europe PMC)	0.78	BioGRID, IntAct
SFPQ	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
SGPL1	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
SGSM2	Two-hybrid, two hybrid pooling approach	physical, physical association	16169070, (Europe PMC)	0.37	BioGRID, IntAct
SH2B1	PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
SH2B3	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SH2D1A	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SH2D2A	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SH2D3A	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	10187783, 24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
SH2D3C	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SH3BGRL	Affinity Capture-MS, pull down, ubiquitin reconstruction	physical, physical association	16729043, 20029029, (Europe PMC)	0.57	BioGRID, IntAct, MINT
SH3BGRL3	ubiquitin reconstruction	physical association	20029029, (Europe PMC)	0.37	IntAct
SH3D21	ubiquitin reconstruction	physical association	20029029, (Europe PMC)	0.37	IntAct
SH3GL2	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	11894095, 15456872, 24658140, 24854121, 25402006, (Europe PMC)	0.57	BioGRID, IntAct, MINT
SH3GL3	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SH3KBP1	Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical, physical association	11894095, 12177062, 12734385, 12771190, 15456872, 16849543, 21635887, (Europe PMC)	0.62	BioGRID, IntAct, MINT
SHC1	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Protein-peptide, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, competition binding, experimental interaction detection, luminescence based mammalian interactome mapping, protein array, protein kinase assay, pull down, tandem affinity purification, ubiquitin reconstruction, x-ray crystallography	association, direct interaction, phosphorylation reaction, physical, physical association	10049786, 10595738, 10635327, 10766863, 11370743, 11408594, 15657067, 16273093, 16729043, 18271526, 19531499, 20473329, 20935677, 21278788, 23178716, 23799367, 23956138, 24189400, 24430869, 24658140, 24797263, 25402006, 26551075, 28065597, 7506413, 7518560, 7542744, 8034616, 8662998, 8810340, 9130710, 9544989, 9756944, (Europe PMC)	0.58, 0.97	BioGRID, IntAct, MINT
SHC2	Affinity Capture-Western, Protein-peptide, protein array	direct interaction, physical	16273093, 24430869, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SHC3	Affinity Capture-Western, Protein-peptide, Reconstituted Complex, protein array	direct interaction, physical	16273093, 8662772, 9507002, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SHC4	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Reconstituted Complex, Two-hybrid, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24430869, 24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
SLA	PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
SLA2	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SLC25A3	anti bait coimmunoprecipitation, tandem affinity purification	association	15657067, 24189400, (Europe PMC)	0.53	IntAct
SLC25A5	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
SLC3A2	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	15657067, 16799092, 24189400, 24797263, (Europe PMC)	0.64	BioGRID, IntAct
SLC5A1	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	physical association	18455122, (Europe PMC)	0.52	IntAct
SLC7A5	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
SNAP25	ubiquitin reconstruction	physical association	20029029, (Europe PMC)	0.37	IntAct
SNCA	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SNX9	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SOCS3	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	12070153, 24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SOCS6	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SORBS2	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
SOS1	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation	physical, physical association	10675333, 18271526, 19289468, 19531499, 20473329, 23956138, 24797263, 26005835, 7510700, 9447973, (Europe PMC)	0.40	BioGRID, IntAct
SOS2	Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	10675333, 18271526, 19531499, 23956138, 24658140, 24797263, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
SPCS2	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
SPRR1A	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
SRC	Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	10358079, 10777553, 10971656, 17158602, 17284441, 20333651, 20624308, 20935677, 21268077, 21278788, 21573184, 23175185, 24189400, 24658140, 25402006, 28065597, (Europe PMC)	0.82	BioGRID, IntAct, MINT
SSR1	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
STAM2	Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, confocal microscopy	colocalization, physical, physical association	15212941, 17403676, (Europe PMC)	0.46	BioGRID, IntAct
STAP2	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
STAT1	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, anti tag coimmunoprecipitation, competition binding, electrophoretic mobility shift assay, luminescence based mammalian interactome mapping, ubiquitin reconstruction	association, physical, physical association	10358079, 12070153, 15284024, 23956138, 24658140, 24797263, 25402006, (Europe PMC)	0.71	BioGRID, IntAct, MINT
STAT2	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
STAT3	anti bait coimmunoprecipitation, fluorescence microscopy, proximity ligation assay, pull down, tandem affinity purification, ubiquitin reconstruction	association, colocalization, physical association	14966128, 15657067, 24135280, 24189400, 24658140, 25241761, (Europe PMC)	0.89	IntAct, MINT
STAT5A	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-localization, PCA, Two-hybrid, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	10358079, 16729043, 22729867, 24135280, 24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
STAT5B	Affinity Capture-Western, Co-localization, pull down	physical, physical association	10558875, 16729043, 22729867, (Europe PMC)	0.40	BioGRID, IntAct, MINT
STIP1	PCA, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.51	BioGRID, IntAct
STUB1	anti tag coimmunoprecipitation, ubiquitin reconstruction	physical association	20029029, 24658140, (Europe PMC)	0.63	IntAct
STX17	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
SUSD1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
SYK	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SYN1	ubiquitin reconstruction	physical association	20029029, (Europe PMC)	0.37	IntAct
TAB1	Affinity Capture-MS, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	18271526, 24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
TBRG4	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
TGFA	Co-crystal Structure, PCA, Two-hybrid, ubiquitin reconstruction, x-ray crystallography	direct interaction, physical, physical association	12297049, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct
TGFB1	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
TLN1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
TLR2	PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	17126326, 24658140, 25402006, (Europe PMC)	0.57	BioGRID, IntAct, MINT
TLR4	anti bait coimmunoprecipitation	physical association	17126326, (Europe PMC)	0.40	IntAct, MINT
TMCO3	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
TNFRSF1A	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
TNK2	Affinity Capture-MS, Affinity Capture-Western, Co-localization, anti bait coimmunoprecipitation	association, physical	15657067, 17182860, 18271526, 18435854, 19815557, 20086093, 20359967, 24413169, (Europe PMC)	0.35	BioGRID, IntAct
TNS3	Affinity Capture-Luminescence, PCA, Two-hybrid, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.58	BioGRID, IntAct
TNS4	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
TOM1L1	Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy	colocalization, physical, physical association	19798056, (Europe PMC)	0.56	BioGRID, IntAct, MINT
TOP1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
TPI1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
TPT1	anti bait coimmunoprecipitation	physical association	21278788, (Europe PMC)	0.40	IntAct
TRAF2	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	18271526, 23972990, 24658140, 25402006, (Europe PMC)	0.51	BioGRID, IntAct
TRIM28	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, (Europe PMC)	0.35	BioGRID, IntAct
TRIM29	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
TRMO	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
TSTD2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
TUBA1A	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, anti bait coimmunoprecipitation, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	15657067, 16799092, 24189400, 24658140, 25402006, (Europe PMC)	0.66	BioGRID, IntAct
TUBA4A	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	16799092, 23956138, 24189400, (Europe PMC)	0.53	BioGRID, IntAct
TUBB	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, (Europe PMC)	0.35	BioGRID, IntAct
TUFM	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
TXN	Affinity Capture-Luminescence, PCA, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	15657067, 20029029, 24658140, (Europe PMC)	0.72	BioGRID, IntAct
UBASH3B	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	15159412, 17880946, 18271526, 23956138, 24189400, 24797263, (Europe PMC)	0.46	BioGRID, IntAct
UBB	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
UBE2V2	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
UBE4B	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
UCHL1	PCA, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.51	BioGRID, IntAct
UROD	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
VAPA	Affinity Capture-MS, PCA, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	20029029, 23956138, (Europe PMC)	0.51	BioGRID, IntAct
VAV1	Affinity Capture-Western, PCA, Protein-peptide, Two-hybrid, ubiquitin reconstruction	physical, physical association	10938113, 16273093, 24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
VAV2	Affinity Capture-MS, Affinity Capture-Western, pull down	association, physical	10938113, 12454019, 18271526, 19531499, 20940296, 24797263, (Europe PMC)	0.35	BioGRID, IntAct, MINT
VPS13A	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
VPS33B	fluorescence microscopy	colocalization	22677173, (Europe PMC)	0.27	IntAct, MINT
WASF3	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
WASL	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
XPOT	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	15657067, 23956138, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
XRN2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	24189400, 24780295, (Europe PMC)	0.53	BioGRID, IntAct
YES1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical, physical association	15657067, 23866081, 24797263, (Europe PMC)	0.56	BioGRID, IntAct
YTHDF1	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
YWHAB	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
YWHAE	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
YWHAQ	PCA, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	15657067, 20029029, 24189400, 24658140, 25402006, (Europe PMC)	0.81	BioGRID, IntAct
YWHAZ	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, anti bait coimmunoprecipitation, filter binding, fluorescence microscopy, ubiquitin reconstruction	association, colocalization, physical, physical association	15225635, 15657067, 19531499, 23956138, 24658140, 25402006, (Europe PMC)	0.70	BioGRID, IntAct
ZAP70	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
ZNF510	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT

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Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
ABL2	PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
ANKS1A	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, anti tag coimmunoprecipitation, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.66	BioGRID, IntAct, MINT
ANKS1B	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
ANXA1	Affinity Capture-MS, anti tag coimmunoprecipitation, imaging technique, tandem affinity purification, ubiquitin reconstruction	association, colocalization, physical, physical association	15581623, 20029029, 24189400, (Europe PMC)	0.70	BioGRID, IntAct, MINT
AOPEP	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
APBA3	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
APBB1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
APBB2	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, luminescence based mammalian interactome mapping, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.66	BioGRID, IntAct, MINT
APBB3	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
APPL1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
BLK	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
BMX	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
CAPN7	fluorescence microscopy	colocalization	24953135, (Europe PMC)	0.27	IntAct, MINT
CBL	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, far western blotting, fluorescence microscopy, isothermal titration calorimetry, pull down, x-ray crystallography	association, colocalization, direct interaction, physical, physical association	10086340, 10428778, 10635327, 11239464, 11370743, 11408594, 12061819, 12593795, 12604776, 12734385, 12803489, 14505571, 14627991, 15107835, 15117950, 15159412, 15210722, 15282549, 15383614, 15465819, 15657067, 15668240, 15677445, 15735736, 15962011, 16105874, 16246327, 16729043, 16849543, 16914641, 16923119, 16969069, 17182860, 17242169, 17486068, 17545148, 17880946, 17971399, 17995934, 18271526, 18273061, 18316398, 18508924, 19155296, 19225046, 19531499, 19578043, 19713535, 19836242, 19947936, 20124286, 20308550, 20562913, 20877636, 20940296, 21772844, 22203672, 22266821, 22394513, 22591401, 22833562, 22976291, 23153581, 23158001, 23175185, 23418353, 23457600, 23774213, 23799367, 23897813, 24714105, 24797263, 25140053, 25521828, 25872741, 26055326, 26177020, 27059931, 28198003, 28791635, 7592693, 7657591, 7782294, 8662998, 9121472, 9130710, 9756944, (Europe PMC)	0.96	BioGRID, IntAct, MINT
CISH	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, luminescence based mammalian interactome mapping, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.66	BioGRID, IntAct, MINT
CLNK	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
CMTM8	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy	colocalization, physical association	16263120, (Europe PMC)	0.56	IntAct, MINT
CRK	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, PCA, Protein-peptide, Two-hybrid, luminescence based mammalian interactome mapping, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	10595738, 16273093, 16729043, 24658140, 25402006, 9617486, 9642287, (Europe PMC)	0.51, 0.59	BioGRID, IntAct, MINT
CRKL	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, proximity ligation assay, pull down, ubiquitin reconstruction	physical, physical association	16729043, 18271526, 23397142, 24658140, 25402006, (Europe PMC)	0.69	BioGRID, IntAct, MINT
CSK	Affinity Capture-Luminescence, Affinity Capture-MS, PCA, Two-hybrid, pull down, ubiquitin reconstruction	physical, physical association	16729043, 24658140, 24797263, 25402006, (Europe PMC)	0.57	BioGRID, IntAct, MINT
CYLC2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
DNAJC13	Affinity Capture-MS, fluorescence microscopy	colocalization, physical	21510942, 28065597, (Europe PMC)	0.27	BioGRID, IntAct, MINT
DOK4	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
DOK5	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
DOK6	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
EEA1	fluorescence microscopy	colocalization	22971756, 24597955, (Europe PMC)	0.43	IntAct, MINT
EGF	Affinity Capture-Luminescence, Affinity Capture-MS, Co-crystal Structure, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, fluorescence-activated cell sorting, molecular sieving, proximity ligation assay, saturation binding, scintillation proximity assay, surface plasmon resonance, transmission electron microscopy, x ray scattering, x-ray crystallography	direct interaction, physical, physical association	10085134, 12093292, 12297050, 12620237, 17697999, 18271526, 19531499, 21439278, 21822280, 22729867, 23597562, 25080504, 25241761, 25453753, 26280537, 2790960, (Europe PMC)	0.96	BioGRID, IntAct, MINT
ERBB2	Affinity Capture-MS, Affinity Capture-Western, Co-localization, anti bait coimmunoprecipitation, beta galactosidase complementation, protein cross-linking with a bifunctional reagent, protein kinase assay, proximity ligation assay, pull down, tandem affinity purification	association, physical, physical association	10572067, 11408594, 15657067, 16207817, 16516204, 16843263, 17148612, 17307140, 17486068, 18803307, 19060928, 19650109, 20211985, 21044682, 21203579, 21278786, 23436906, 23866081, 24189400, 24557338, 25241761, (Europe PMC)	0.96	BioGRID, IntAct, MINT
ESR1	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	physical, physical association	17284441, 20935677, 28065597, (Europe PMC)	0.40, 0.52	BioGRID, IntAct, MINT
FANCC	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
FES	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
FRAT2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
GAB2	anti tag coimmunoprecipitation	association	16253990, 19172738, (Europe PMC)	0.53	IntAct, MINT
GRB10	PCA, Reconstituted Complex, Two-hybrid, pull down, two hybrid, ubiquitin reconstruction	direct interaction, physical, physical association	24658140, 25402006, 9506989, (Europe PMC)	0.65	BioGRID, IntAct, MINT
GRB2	Affinity Capture-MS, Affinity Capture-Western, PCA, Protein-peptide, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, competition binding, protein array, pull down, surface plasmon resonance, tandem affinity purification, ubiquitin reconstruction	association, direct interaction, physical, physical association	10026169, 10085134, 10229072, 10595738, 11370743, 11408594, 11896612, 11960376, 12577067, 1322798, 14679214, 15657067, 16273093, 16729043, 16799092, 17242169, 17971399, 18271526, 19254954, 19289468, 19531499, 19836242, 20124286, 20473329, 21278786, 21278788, 21596750, 21706016, 23178716, 23799367, 23956138, 24189400, 24658140, 24797263, 25402006, 27059931, 7506413, 7510700, 7518560, 7527043, 7592693, 7650032, 8647858, 8662998, 8810340, 8887653, 8940013, 9020117, 9050991, 9416834, 9886492, (Europe PMC)	0.98	BioGRID, IntAct, MINT
GRK2	anti tag coimmunoprecipitation, imaging technique	colocalization, physical association	15620700, (Europe PMC)	0.46	IntAct, MINT
HEMGN	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
IRS1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
IRS4	Affinity Capture-MS, Protein-peptide, protein array	direct interaction, physical	16273093, 24797263, (Europe PMC)	0.44	BioGRID, IntAct, MINT
JAK2	Affinity Capture-Western, Biochemical Activity, Protein-peptide, protein array	direct interaction, physical	10358079, 16273093, 23838182, (Europe PMC)	0.44	BioGRID, IntAct, MINT
KPNA1	anti bait coimmunoprecipitation	physical association	20692258, (Europe PMC)	0.40	IntAct, MINT
LAMP1	fluorescence microscopy	colocalization	21510942, 24597955, (Europe PMC)	0.43	IntAct, MINT
MAPK8IP1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
MAPK8IP2	PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
MAPKAPK3	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
MUC1	Affinity Capture-Luminescence, Affinity Capture-Western, Biochemical Activity, Co-localization, PCA, Two-hybrid, anti bait coimmunoprecipitation, coimmunoprecipitation, cross-linking study, luminescence based mammalian interactome mapping, ubiquitin reconstruction	physical, physical association	11278868, 11483589, 16983337, 21258405, 24658140, 25402006, (Europe PMC)	0.77	BioGRID, IntAct, MINT
NANS	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
NCK1	Affinity Capture-Western, PCA, Protein-peptide, Reconstituted Complex, Two-hybrid, coimmunoprecipitation, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	10026169, 1333047, 16273093, 24658140, 25402006, 8662998, 9362449, (Europe PMC)	0.70	BioGRID, IntAct, MINT
NUMB	protein array	direct interaction	16273093, (Europe PMC)	0.44	IntAct, MINT
NUMBL	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
PDCD6IP	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	12771190, 15456872, 15557335, 24658140, 25402006, (Europe PMC)	0.57	BioGRID, IntAct, MINT
PIK3R1	Affinity Capture-MS, Affinity Capture-Western, Co-localization, Protein-peptide, coimmunoprecipitation, competition binding, protein array, proximity ligation assay	association, direct interaction, physical, physical association	16273093, 19531499, 21701776, 25241761, 7797556, 8662998, (Europe PMC)	0.78	BioGRID, IntAct, MINT
PIK3R2	Affinity Capture-MS, PCA, Protein-peptide, Reconstituted Complex, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	1334406, 16273093, 19531499, 23956138, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
PIK3R3	Co-localization, PCA, Protein-peptide, Two-hybrid, protein array, proximity ligation assay, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25241761, 25402006, (Europe PMC)	0.70	BioGRID, IntAct, MINT
PLCG1	Affinity Capture-MS, Affinity Capture-Western, Protein-peptide, coimmunoprecipitation, cross-linking study, far western blotting, protein array, pull down	association, direct interaction, physical, physical association	11983899, 12061819, 12803489, 14568990, 16273093, 19605547, 24797263, 7693694, 7993895, 9020117, 9207933, 9756944, (Europe PMC)	0.85	BioGRID, IntAct, MINT
PLCG2	Affinity Capture-Luminescence, Co-localization, PCA, Protein-peptide, Two-hybrid, luminescence based mammalian interactome mapping, protein array, proximity ligation assay, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25241761, 25402006, (Europe PMC)	0.74	BioGRID, IntAct, MINT
PPP2CB	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
PTK6	Affinity Capture-Western, Protein-peptide, protein array	direct interaction, physical	16273093, 8940083, (Europe PMC)	0.44	BioGRID, IntAct, MINT
PTPN1	Affinity Capture-Luminescence, Biochemical Activity, Co-crystal Structure, PCA, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy, protein kinase assay, ubiquitin reconstruction	colocalization, phosphorylation reaction, physical, physical association	10889023, 24658140, 25402006, 25796184, 7693694, 8621392, 9050838, 9355745, (Europe PMC)	0.82	BioGRID, IntAct, MINT
PTPN11	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Protein-peptide, Two-hybrid, protein array, pull down	direct interaction, physical, physical association	16273093, 16729043, 20473329, 28065597, 7673163, 8959326, 9756944, (Europe PMC)	0.61	BioGRID, IntAct, MINT
PTPN2	Affinity Capture-Western, genetic interference	genetic interaction, physical	11514572, 15592458, (Europe PMC)	0.17	BioGRID, IntAct, MINT
PTPN6	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, pull down	association, physical	28065597, 7673163, 9733788, (Europe PMC)	0.35	BioGRID, IntAct, MINT
RAPH1	anti bait coimmunoprecipitation	physical association	24076656, (Europe PMC)	0.40	IntAct, MINT
RASA1	Protein-peptide, Reconstituted Complex, protein array	direct interaction, physical	1385407, 16273093, 8647858, (Europe PMC)	0.44	BioGRID, IntAct, MINT
RIN2	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SH2B1	PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
SH2B3	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SH2D1A	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SH2D2A	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SH3BGRL	Affinity Capture-MS, pull down, ubiquitin reconstruction	physical, physical association	16729043, 20029029, (Europe PMC)	0.57	BioGRID, IntAct, MINT
SH3GL2	Affinity Capture-Luminescence, Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	11894095, 15456872, 24658140, 24854121, 25402006, (Europe PMC)	0.57	BioGRID, IntAct, MINT
SH3KBP1	Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical, physical association	11894095, 12177062, 12734385, 12771190, 15456872, 16849543, 21635887, (Europe PMC)	0.62	BioGRID, IntAct, MINT
SHC1	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Protein-peptide, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, competition binding, experimental interaction detection, luminescence based mammalian interactome mapping, protein array, protein kinase assay, pull down, tandem affinity purification, ubiquitin reconstruction, x-ray crystallography	association, direct interaction, phosphorylation reaction, physical, physical association	10049786, 10595738, 10635327, 10766863, 11370743, 11408594, 15657067, 16273093, 16729043, 18271526, 19531499, 20473329, 20935677, 21278788, 23178716, 23799367, 23956138, 24189400, 24430869, 24658140, 24797263, 25402006, 26551075, 28065597, 7506413, 7518560, 7542744, 8034616, 8662998, 8810340, 9130710, 9544989, 9756944, (Europe PMC)	0.58, 0.97	BioGRID, IntAct, MINT
SHC2	Affinity Capture-Western, Protein-peptide, protein array	direct interaction, physical	16273093, 24430869, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SHC3	Affinity Capture-Western, Protein-peptide, Reconstituted Complex, protein array	direct interaction, physical	16273093, 8662772, 9507002, (Europe PMC)	0.44	BioGRID, IntAct, MINT
SLA	PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
SRC	Affinity Capture-Western, PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	association, physical, physical association	10358079, 10777553, 10971656, 17158602, 17284441, 20333651, 20624308, 20935677, 21268077, 21278788, 21573184, 23175185, 24189400, 24658140, 25402006, 28065597, (Europe PMC)	0.82	BioGRID, IntAct, MINT
STAT1	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Two-hybrid, anti tag coimmunoprecipitation, competition binding, electrophoretic mobility shift assay, luminescence based mammalian interactome mapping, ubiquitin reconstruction	association, physical, physical association	10358079, 12070153, 15284024, 23956138, 24658140, 24797263, 25402006, (Europe PMC)	0.71	BioGRID, IntAct, MINT
STAT3	anti bait coimmunoprecipitation, fluorescence microscopy, proximity ligation assay, pull down, tandem affinity purification, ubiquitin reconstruction	association, colocalization, physical association	14966128, 15657067, 24135280, 24189400, 24658140, 25241761, (Europe PMC)	0.89	IntAct, MINT
STAT5B	Affinity Capture-Western, Co-localization, pull down	physical, physical association	10558875, 16729043, 22729867, (Europe PMC)	0.40	BioGRID, IntAct, MINT
STX17	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
SYK	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
TGFB1	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
TLN1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
TLR2	PCA, Two-hybrid, anti bait coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	17126326, 24658140, 25402006, (Europe PMC)	0.57	BioGRID, IntAct, MINT
TLR4	anti bait coimmunoprecipitation	physical association	17126326, (Europe PMC)	0.40	IntAct, MINT
TNS4	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
TOM1L1	Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy	colocalization, physical, physical association	19798056, (Europe PMC)	0.56	BioGRID, IntAct, MINT
TRMO	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
TSTD2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
VAV2	Affinity Capture-MS, Affinity Capture-Western, pull down	association, physical	10938113, 12454019, 18271526, 19531499, 20940296, 24797263, (Europe PMC)	0.35	BioGRID, IntAct, MINT
VPS33B	fluorescence microscopy	colocalization	22677173, (Europe PMC)	0.27	IntAct, MINT
ZAP70	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
ZNF510	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT

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Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
AAMDC	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AAMP	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AASDH	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ABCA1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ABCD3	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ABCF2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ABL1	PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
ABL2	PCA, Protein-peptide, Two-hybrid, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.59	BioGRID, IntAct, MINT
ACACA	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ACACB	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ACADSB	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ACOT9	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
ACP1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ACSL3	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
ACTA2	Affinity Capture-MS	physical	19531499, (Europe PMC)	NA	BioGRID
ACTB	Affinity Capture-Western	physical	22366308, (Europe PMC)	NA	BioGRID
ACTN4	Affinity Capture-Luminescence, PCA, Two-hybrid	physical	24658140, 25402006, (Europe PMC)	NA	BioGRID
ACTN4	ubiquitin reconstruction	physical association	24658140, (Europe PMC)	0.37	IntAct
ACTR2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ADAM5	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ADAR	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ADRM1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
AFG3L2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AGER	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	physical association	16954185, (Europe PMC)	0.52	IntAct
AGO2	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, bimolecular fluorescence complementation, protein kinase assay, pull down	association, direct interaction, phosphorylation reaction, physical association	23636329, (Europe PMC)	0.68	IntAct
AGTPBP1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
AHNAK	Affinity Capture-MS, PCA, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	20029029, 24189400, (Europe PMC)	0.55	BioGRID, IntAct
AHSA1	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
AHSG	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
AIFM1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AIP	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
AK4	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AKAP12	PCA, anti tag coimmunoprecipitation, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.51	BioGRID, IntAct
AKAP17A	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
AKT1	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
AKT2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AKTIP	Affinity Capture-Western	physical	25151576, 27535835, (Europe PMC)	NA	BioGRID
ALCAM	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
ALDH3A2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
ALDH7A1	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ALDOA	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
ANKRD13A	Affinity Capture-MS, Affinity Capture-Western	physical	22298428, 23956138, (Europe PMC)	NA	BioGRID
ANKRD13B	Affinity Capture-Western	physical	22298428, (Europe PMC)	NA	BioGRID
ANKRD13D	Affinity Capture-Western	physical	22298428, (Europe PMC)	NA	BioGRID
ANKS1A	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, anti tag coimmunoprecipitation, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.66	BioGRID, IntAct, MINT
ANKS1B	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
ANO5	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, (Europe PMC)	0.35	BioGRID, IntAct
ANXA1	Affinity Capture-MS, anti tag coimmunoprecipitation, imaging technique, tandem affinity purification, ubiquitin reconstruction	association, colocalization, physical, physical association	15581623, 20029029, 24189400, (Europe PMC)	0.70	BioGRID, IntAct, MINT
ANXA2	anti bait coimmunoprecipitation, confocal microscopy	colocalization, physical association	25136068, (Europe PMC)	0.46	IntAct
AOPEP	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
AP1B1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
AP1G1	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
AP1G2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
AP1M1	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
AP1M2	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
AP1S1	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
AP1S2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AP2A1	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	20029029, 23956138, 24189400, 24797263, (Europe PMC)	0.53	BioGRID, IntAct
AP2A2	Affinity Capture-MS, tandem affinity purification	association, physical	23956138, 24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
AP2B1	Affinity Capture-MS, tandem affinity purification	association, physical	23956138, 24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
AP2M1	Affinity Capture-MS, PCA, tandem affinity purification, ubiquitin reconstruction	association, physical, physical association	20029029, 23956138, 24189400, 24797263, (Europe PMC)	0.55	BioGRID, IntAct
AP2S1	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 24797263, (Europe PMC)	0.35	BioGRID, IntAct
AP3D1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AP3M1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AP3S1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
APBA3	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
APBB1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
APBB2	Affinity Capture-Luminescence, PCA, Protein-peptide, Two-hybrid, luminescence based mammalian interactome mapping, protein array, ubiquitin reconstruction	direct interaction, physical, physical association	16273093, 24658140, 25402006, (Europe PMC)	0.66	BioGRID, IntAct, MINT
APBB3	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
APEX1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	24780295, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
API5	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
APOB	Affinity Capture-MS, tandem affinity purification	association, physical	24189400, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
APP	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
APPL1	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
APRT	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
AR	Affinity Capture-Western, Co-localization	physical	15288768, 15305378, (Europe PMC)	NA	BioGRID
AREG	Reconstituted Complex	physical	10085134, (Europe PMC)	NA	BioGRID
ARF4	Affinity Capture-Western, Two-hybrid	physical	12446727, (Europe PMC)	NA	BioGRID
ARF6	Affinity Capture-MS, PCA	physical	20029029, 24797263, (Europe PMC)	NA	BioGRID
ARF6	ubiquitin reconstruction	physical association	20029029, (Europe PMC)	0.37	IntAct
ARFGEF1	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
ARFGEF3	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
ARHGAP1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ARHGAP29	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ARHGAP32	Affinity Capture-Western	physical	12446789, (Europe PMC)	NA	BioGRID
ARHGEF2	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ARHGEF5	Affinity Capture-MS	physical	23956138, (Europe PMC)	NA	BioGRID
ARHGEF7	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
ARL1	Affinity Capture-MS	physical	23956138, 24797263, (Europe PMC)	NA	BioGRID
ARMC6	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ARMC8	Affinity Capture-MS, tandem affinity purification	association, physical	23956138, 24189400, (Europe PMC)	0.35	BioGRID, IntAct
ARMCX5	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ARPC5	ubiquitin reconstruction	physical association	20029029, (Europe PMC)	0.37	IntAct
ARRB1	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
ARRB2	PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
ASNS	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ATAD1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ATAD3B	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ATF7IP2	Affinity Capture-MS	physical	28065597, (Europe PMC)	NA	BioGRID
ATIC	PCA, ubiquitin reconstruction	physical, physical association	20029029, (Europe PMC)	0.37	BioGRID, IntAct
ATP1A1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, 24797263, 28065597, (Europe PMC)	0.35	BioGRID, IntAct
ATP1B1	Affinity Capture-MS, anti bait coimmunoprecipitation	association, physical	16799092, (Europe PMC)	0.35	BioGRID, IntAct
ATP2A2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical	15657067, 23956138, 24189400, (Europe PMC)	0.53	BioGRID, IntAct
ATP2B1	Affinity Capture-MS	physical	24797263, (Europe PMC)	NA	BioGRID
ATP2B4	Affinity Capture-MS	physical	24189400, (Europe PMC)	NA	BioGRID
ATP2B4	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
ATP5F1A	Affinity Capture-MS	physical	24189400, 24797263, (Europe PMC)	NA	BioGRID
ATP5F1A	tandem affinity purification	association	24189400, (Europe PMC)	0.35	IntAct
ATP5F1B	anti bait coimmunoprecipitation	association	15657067, (Europe PMC)	0.35	IntAct
ATP5F1C	Affinity Capture-MS, Two-hybrid	physical	16169070, 19531499, (Europe PMC)	NA	BioGRID
ATP5F1C	two hybrid pooling approach	physical association	16169070, (Europe PMC)	0.37	IntAct
ATP5MG	Affinity Capture-MS	physical

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