Top ACP1
Download FASTA sequences of ACP1-substrates in HumansSubstrate Gene Name Substrate UniProt_AC DephosphoSite and sequence (+/-5) Bioassay Type PubMed ID View in Europe PMC Reliability of the interaction EGFR P00533 NA In vitro 9784386 , 2787757 , 7532092 , Europe PMC INSR P06213 NA In vivo 17353188 , 9299573 , Europe PMC PDGFRB P09619 Tyr-857_MRDSNyISKGS In vitro and in vivo 12149261 , Europe PMC FCGR2A P12318 NA In vitro and in vivo 17537991 , Europe PMC SRC P12931 Tyr-424_IEDNEyTARQG, Tyr-535 _STEPQyQPGEN In vitro and in vivo 19088431 , Europe PMC KDR P35968 NA In vitro and in vivo 10608891 , Europe PMC STAT5A P42229 NA In vitro and in vivo 14637146 , Europe PMC PTK2 Q05397 NA In vitro and in vivo 12055185 , Europe PMC LAT O43561 NA In vitro 17537991 , Europe PMC SLC4A1 P02730 NA In vitro 2418829 , Europe PMC FABP4 P15090 NA In vitro 1304913 , Europe PMC ACP1 P24666 NA In vitro 8576112 , 16890200 , Europe PMC AKT1 P31749 Ser-473_HFPQFsYSASG In vivo 17353188 , Europe PMC CTNNB1 P35222 NA In vivo 12438242 , 16287083 , Europe PMC ZAP70 P43403 Tyr-292_LNSDGyTPEPA In vitro 11976341 , Europe PMC
Pathway ID Pathway Name Pathway Description (KEGG) hsa00730 Thiamine metabolism hsa00740 Riboflavin metabolism hsa01100 Metabolic pathways hsa04520 Adherens junction Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ACP1 Affinity Capture-MS, anti bait coimmunoprecipitation physical, physical association 17353931 , 27432908 , (Europe PMC )0.40 BioGRID, IntAct ACTB Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ACTBL2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ADA Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID BARD1 Two-hybrid physical 22990118 , (Europe PMC )NA BioGRID CDK2 Affinity Capture-MS physical 21319273 , (Europe PMC )NA BioGRID COPS5 Affinity Capture-MS physical 21145461 , (Europe PMC )NA BioGRID CTNNB1 Co-localization physical 12438242 , (Europe PMC )NA BioGRID DLD Affinity Capture-MS, cross-linking study association, physical 29128334 , (Europe PMC )0.35 BioGRID, IntAct DNAJC13 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP12 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP28 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID EGFR Affinity Capture-MS physical 24797263 , (Europe PMC )NA BioGRID EPHA2 Affinity Capture-Western, Biochemical Activity physical 12167657 , (Europe PMC )NA BioGRID EPHB1 Affinity Capture-Western, Reconstituted Complex physical 9499402 , (Europe PMC )NA BioGRID EPHB2 Affinity Capture-Western physical 9499402 , (Europe PMC )NA BioGRID FN1 Affinity Capture-MS physical 19738201 , (Europe PMC )NA BioGRID FNBP1L Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct GADD45GIP1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID GOT1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID INSR Affinity Capture-Western physical 9299573 , (Europe PMC )NA BioGRID ITGA4 Affinity Capture-MS physical 22623428 , (Europe PMC )NA BioGRID KDR Two-hybrid physical 10608891 , (Europe PMC )NA BioGRID KEAP1 Affinity Capture-MS physical 27621311 , (Europe PMC )NA BioGRID MCM2 Affinity Capture-MS physical 25963833 , (Europe PMC )NA BioGRID MRPL20 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct PCBP1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PITPNA Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID POTEE Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PPIL3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID RPL12 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SFMBT1 Two-hybrid, two hybrid pooling approach physical, physical association 16189514 , (Europe PMC )0.37 BioGRID, IntAct TALDO1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TES Affinity Capture-MS physical 28378594 , (Europe PMC )NA BioGRID TKT Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TKTL2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID VCAM1 Affinity Capture-MS, cross-linking study association, physical 19738201 , 22623428 , (Europe PMC )0.35 BioGRID, IntAct ZAP70 Affinity Capture-Western physical 11976341 , (Europe PMC )NA BioGRID ZBTB43 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source DLD Affinity Capture-MS, cross-linking study association, physical 29128334 , (Europe PMC )0.35 BioGRID, IntAct EIF1B anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct EIF6 {ECO:0000255|HAMAP-Rule:MF_03132, anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct EPB41 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct FNBP1L Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct IKBKE anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct KSR1 anti tag coimmunoprecipitation association 27086506 , (Europe PMC )0.35 IntAct MRPL20 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct NR3C1 display technology physical association 20195357 , (Europe PMC )0.40 IntAct PAK2 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct SFMBT1 Two-hybrid, two hybrid pooling approach physical, physical association 16189514 , (Europe PMC )0.37 BioGRID, IntAct TNIK anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct VCAM1 Affinity Capture-MS, cross-linking study association, physical 19738201 , 22623428 , (Europe PMC )0.35 BioGRID, IntAct VHL anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ACP1 Affinity Capture-MS, anti bait coimmunoprecipitation physical, physical association 17353931 , 27432908 , (Europe PMC )0.40 BioGRID, IntAct ACTB Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ACTBL2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ADA Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID BARD1 Two-hybrid physical 22990118 , (Europe PMC )NA BioGRID CDK2 Affinity Capture-MS physical 21319273 , (Europe PMC )NA BioGRID COPS5 Affinity Capture-MS physical 21145461 , (Europe PMC )NA BioGRID CTNNB1 Co-localization physical 12438242 , (Europe PMC )NA BioGRID DLD Affinity Capture-MS, cross-linking study association, physical 29128334 , (Europe PMC )0.35 BioGRID, IntAct DNAJC13 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP12 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID DUSP28 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID EGFR Affinity Capture-MS physical 24797263 , (Europe PMC )NA BioGRID EIF1B anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct EIF6 {ECO:0000255|HAMAP-Rule:MF_03132, anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct EPB41 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct EPHA2 Affinity Capture-Western, Biochemical Activity physical 12167657 , (Europe PMC )NA BioGRID EPHB1 Affinity Capture-Western, Reconstituted Complex physical 9499402 , (Europe PMC )NA BioGRID EPHB2 Affinity Capture-Western physical 9499402 , (Europe PMC )NA BioGRID FN1 Affinity Capture-MS physical 19738201 , (Europe PMC )NA BioGRID FNBP1L Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct GADD45GIP1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID GOT1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID IKBKE anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct INSR Affinity Capture-Western physical 9299573 , (Europe PMC )NA BioGRID ITGA4 Affinity Capture-MS physical 22623428 , (Europe PMC )NA BioGRID KDR Two-hybrid physical 10608891 , (Europe PMC )NA BioGRID KEAP1 Affinity Capture-MS physical 27621311 , (Europe PMC )NA BioGRID KSR1 anti tag coimmunoprecipitation association 27086506 , (Europe PMC )0.35 IntAct MCM2 Affinity Capture-MS physical 25963833 , (Europe PMC )NA BioGRID MRPL20 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct NR3C1 display technology physical association 20195357 , (Europe PMC )0.40 IntAct PAK2 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct PCBP1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PITPNA Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID POTEE Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PPIL3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID RPL12 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SFMBT1 Two-hybrid, two hybrid pooling approach physical, physical association 16189514 , (Europe PMC )0.37 BioGRID, IntAct TALDO1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TES Affinity Capture-MS physical 28378594 , (Europe PMC )NA BioGRID TKT Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TKTL2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TNIK anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct VCAM1 Affinity Capture-MS, cross-linking study association, physical 19738201 , 22623428 , (Europe PMC )0.35 BioGRID, IntAct VHL anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct ZAP70 Affinity Capture-Western physical 11976341 , (Europe PMC )NA BioGRID ZBTB43 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID
Phosphorylating Kinases Phosphoresidues Detection Method PubMed IDs Source
Visualize a network of protein kinases and phosphatases phosphorylating and dephosphorylating this protein respectively
FYN Y132_QLIIEDPyYGNDSDF , Y133_LIIEDPYyGNDSDFE , in vitro, in vivo 17016520 , 9038134 ,(Europe PMC )HPRD, LCK Y132_QLIIEDPyYGNDSDF , Y133_LIIEDPYyGNDSDFE , in vitro, in vivo 17016520 , 9038134 ,(Europe PMC )HPRD, PhosphoSitePlus , Unknown S20_CLGNICRsPIAEAVF , T32_AVFRKLVtDQNISEN , Y132_QLIIEDPyYGNDSDF , HTP, in vivo 15951569 , 17016520 , 18083107 , 20068231 ,(Europe PMC )HPRD, PhosphoELM ,
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