Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - Adherens junction - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| PTPRF | P10586 | INSR, MET, PTPRF, CTNNB1, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN1 | P18031 | INPPL1, LAT, JAK2, CTNND1, STAM2, EGFR, ESR1, RAF1, INSR, IGF1R, MET, PDGFRB, GHR, ACTN1, SRC, PTPN1, PLCG1, EPOR, RASA1, NFKBIA, EPHA3, PTPN6, TYK2, CTNNB1, IRS1, STAT3, STAT6, STAT5A, CRK, NSF, GSK3B, STAT5B, BCAR1, CAV1, PTK2, PTPN11, TJP1, GAB1, CTTN, ARHGAP12, LPP, DOK1, TRPV6, ALK, PTK6, PTK6, PAG1, | Non-protein substrates of this phosphatase are not reported yet |
| PTPRB | P23467 | MET, KDR, TEK, EGFR, | Non-protein substrates of this phosphatase are not reported yet |
| ACP1 | P24666 | LAT, EGFR, SLC4A1, INSR, PDGFRB, FCGR2A, SRC, FABP4, ACP1, AKT1, CTNNB1, KDR, STAT5A, ZAP70, PTK2, | FMN, |
| PTPRM | P28827 | CTNND1, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN6 | P29350 | JAK2, CTNND1, NFAT5, EGFR, ESR1, NTRK1, LCK, LYN, ROS1, KIT, ACTN1, SRC, CD33, CD22, NOS1, HOXA10, KDR, CASP8, GAB2, ERBB2, ERBB4, | Non-protein substrates of this phosphatase are not reported yet |
| PTPRJ | Q12913 | LAT, CTNND1, EGFR, FYN, LYN, RET, MET, PDGFRB, SRC, PLCG1, CBL, MAPK3, PIK3R1, MAPK1, KDR, TJP1, OCLN, | Non-protein substrates of this phosphatase are not reported yet |
| Protein substrates in this pathway |
| Non-protein substrates in this pathway |
Non-protein substrates involved in this pathway are unknown (yet!)