DEPOD - human DEPhOsphorylation Database

Basic Information
Phosphatases
Pathway
Interacting Proteins
Phosphorylating Kinases

Gene Name	RASA1 (QuickGO)	Interactive visualization of RASA1 structures (A quick tutorial to explore the interctive visulaization) Representative structure: 2GQI
Synonyms	RASA1, GAP, RASA
Protein Name	RASA1
Alternative Name(s)	Ras GTPase-activating protein 1;GAP;GTPase-activating protein;RasGAP;Ras p21 protein activator;p120GAP;
Protein Family	noSimilarity_annotations
EntrezGene ID	5921 (Comparitive Toxicogenomics)
UniProt AC (Human)	P20936 (protein sequence)
Enzyme Class	N/A
Molecular Weight	116403 Dalton
Protein Length	1047 amino acids (AA)
Genome Browsers	NCBI \| ENSG00000145715 (Ensembl) \| UCSC
Crosslinking annotations	Query our ID-mapping table
Orthologues	Quest For Orthologues (QFO) \| GeneTree \| eggNOG - KOG3508 \| eggNOG - ENOG410XPU1
Phosphorylation Network	Visualize

Domain organization, Expression, Diseases

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Localization, Function, Catalytic activity and Sequence

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Motif information from Eukaryotic Linear Motif atlas (ELM)

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Gene Ontology (P: Process; F: Function and C: Component terms)

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KEGG Pathway
Reactome Pathway

Pathway ID	Pathway Name	Pathway Description (KEGG)
hsa04010	MAPK signaling pathway	The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
hsa04014	Ras signaling pathway	The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
hsa04360	Axon guidance	Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.

Pathway ID	Pathway Name	Pathway Description (KEGG)
R-HSA-186763	Downstream signal transduction.	The role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of around 100 amino acids that can bind a phosphorylated tyrosine residue. These downstream molecules are activated upon binding to, or phosphorylated by, the receptor kinases intrinsic to PDGF receptors.Some of the dowstream molecules are themselves enzymes, such as phosphatidylinositol 3'-kinase (PI3K), phospholipase C (PLC-gamma), the Src family of tyrosine kinases, the tyrosine phosphatase SHP2, and a GTPase activating protein (GAP) for Ras. Others such as Grb2 are adaptor molecules which link the receptor with downstream catalytic molecules
R-HSA-3928662	EPHB-mediated forward signaling.	Multiple EPHB receptors contribute directly to dendritic spine development and morphogenesis. These are more broadly involved in post-synaptic development through activation of focal adhesion kinase (FAK) and Rho family GTPases and their GEFs. Dendritic spine morphogenesis is a vital part of the process of synapse formation and maturation during CNS development. Dendritic spine morphogenesis is characterized by filopodia shortening followed by the formation of mature mushroom-shaped spines (Moeller et al. 2006). EPHBs control neuronal morphology and motility by modulation of the actin cytoskeleton. EPHBs control dendritic filopodia motility, enabling synapse formation. EPHBs exert these effects through interacting with the guanine exchange factors (GEFs) such as intersectin and kalirin. The intersectin-CDC42-WASP-actin and kalirin-RAC-PAK-actin pathways have been proposed to regulate the EPHB receptor mediated morphogenesis and maturation of dendritic spines in cultured hippocampal and cortical neurons (Irie & Yamaguchi 2002, Penzes et al. 2003). EPHBs are also involved in the regulation of dendritic spine morphology through FAK which activates the RHOA-ROCK-LIMK-1 pathway to suppress cofilin activity and inhibit cofilin-mediated dendritic spine remodeling (Shi et al. 2009)
R-HSA-5218921	VEGFR2 mediated cell proliferation.	VEGFR2 stimulates ERK not via GRB2-SOS-RAS, but via pY1175-dependent phosphorylation of PLC gamma and subsequent activation of PKCs. PKC plays an important mediatory role in the proliferative Ras/Raf/MEK/ERK pathway. PKC alpha can intersect the Ras/Raf/MEK/ERK cascade at the level of Ras (Clark et al. 2004) or downstream of Ras through direct phosphorylation of Raf (Kolch et al. 1993). VEGF stimulation leads to Ras activation in a Ras-guanine nucleotide exchange factor (GEF) independent mechanism. It rather relies on modulating the regulation of Ras-GTPase activating protein (GAP) than regulation of Ras-GEFS (Wu et al. 2003)
R-HSA-5658442	Regulation of RAS by GAPs.	The intrinsic GTPase activity of RAS proteins is stimulated by the GAP proteins, of which there are at least 10 in the human genome (reviewed in King et al, 2013)
R-HSA-6802949	Signaling by RAS mutants.	Members of the RAS gene family were the first oncogenes to be identified, and mutations in RAS are present in ~20-30% of human cancers (reviewed in Prior et al, 2012). Mutations in the KRAS gene are the most prevalent, and are found with high frequency in colorectal cancer, non-small cell lung cancer and pancreatic cancer, among others. The reasons for the lower prevalence of HRAS and NRAS mutations in human cancers are not fully understood, but may reflect gene-specific functions as well as differential codon usage and spatio-temporal regulation (reviewed in Prior et al, 2012; Stephen et al, 2014; Pylayeva-Gupta et al, 2011). Activating RAS mutations contribute to cellular proliferation, transformation and survival by activating the MAPK signaling pathway, the AKT pathway and the RAL GDS pathway, among others (reviewed in Stephen et al, 2014; Pylayeva-Gupta et al, 2011).Although the frequency and distribution varies between RAS genes and cancer types, the vast majority of activating RAS mutations occur at one of three residues - G12, G13 and Q61. Mutations at these sites favour the RAS:GTP bound form and yield constitutively active versions of the protein (reviewed in Prior et al, 2012)
R-HSA-8849471	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.	PTK6 promotes cell motility and migration by regulating the activity of RHO GTPases RAC1 (Chen et al. 2004) and RHOA (Shen et al. 2008). PTK6 inhibits RAS GTPase activating protein RASA1 (Shen et al. 2008) and may be involved in MAPK7 (ERK5) activation (Ostrander et al. 2007, Zheng et al

BioGRID
IntAct
MINT
ALL

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Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
ANXA6	Far Western, Reconstituted Complex	physical	10571081, (Europe PMC)	NA	BioGRID
APP	Reconstituted Complex	physical	21832049, (Europe PMC)	NA	BioGRID
ARHGAP35	Affinity Capture-Western, Reconstituted Complex	physical	8189062, 8419471, 9034330, (Europe PMC)	NA	BioGRID
BBS10	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
BTRC	Phenotypic Suppression	genetic	12151397, (Europe PMC)	NA	BioGRID
CAV2	Affinity Capture-Western, Reconstituted Complex	physical	12091389, (Europe PMC)	NA	BioGRID
CD5	Affinity Capture-Western, pull down	association, physical	9603468, (Europe PMC)	0.35	BioGRID, IntAct, MINT
CSK	Reconstituted Complex	physical	7544435, (Europe PMC)	NA	BioGRID
DNAJA3	Affinity Capture-Western, Reconstituted Complex	physical	11116152, (Europe PMC)	NA	BioGRID
DOK1	Affinity Capture-Western, Protein-peptide, Reconstituted Complex	physical	10688886, 10799545, 10822173, 11551902, 15151996, 22974441, 9008161, 9478921, 9822717, (Europe PMC)	NA	BioGRID
DOK2	Affinity Capture-Western	physical	10822173, 9478921, (Europe PMC)	NA	BioGRID
EGFR	Protein-peptide, Reconstituted Complex, protein array	direct interaction, physical	1385407, 16273093, 8647858, (Europe PMC)	0.44	BioGRID, IntAct, MINT
EIF1	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
EPHB2	Affinity Capture-Western, Reconstituted Complex	physical	10644995, 9233798, (Europe PMC)	NA	BioGRID
EPHB3	Affinity Capture-Western, Reconstituted Complex	physical	9674711, (Europe PMC)	NA	BioGRID
ERBB2	Protein-peptide, protein array, two hybrid array	direct interaction, physical, physical association	16273093, 24412244, (Europe PMC)	0.59	BioGRID, IntAct, MINT
ERBB3	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
ERBB4	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
EZH2	Two-hybrid	physical	21900206, (Europe PMC)	NA	BioGRID
FGFR1	Reconstituted Complex	physical	8321198, (Europe PMC)	NA	BioGRID
G3BP1	Affinity Capture-Western	physical	9632780, (Europe PMC)	NA	BioGRID
GRB2	Affinity Capture-Western	physical	12441060, (Europe PMC)	NA	BioGRID
HCK	Affinity Capture-Western, Reconstituted Complex	physical	7782336, (Europe PMC)	NA	BioGRID
HNRNPL	Affinity Capture-RNA	physical	28611215, (Europe PMC)	NA	BioGRID
HRAS	Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Reconstituted Complex, x-ray crystallography	direct interaction, physical	11389730, 26721396, 7628625, 9219684, (Europe PMC)	0.44	BioGRID, IntAct
HTT	Affinity Capture-Western, Reconstituted Complex	physical	9079622, (Europe PMC)	NA	BioGRID
IGF1R	Affinity Capture-Western, Reconstituted Complex, pull down	association, physical	7642582, (Europe PMC)	0.35	BioGRID, IntAct, MINT
INSR	Affinity Capture-Western, pull down	physical, physical association	1331107, 9593725, (Europe PMC)	0.40	BioGRID, IntAct, MINT
KDR	Affinity Capture-Western	physical	10319320, (Europe PMC)	NA	BioGRID
KHDRBS1	Affinity Capture-Western, Reconstituted Complex	physical	11604231, 1385407, 1545818, 8189062, 8419471, 9743338, (Europe PMC)	NA	BioGRID
LCK	Biochemical Activity	physical	11389730, (Europe PMC)	NA	BioGRID
MAP4K4	Affinity Capture-Western	physical	10669731, (Europe PMC)	NA	BioGRID
NCK1	Affinity Capture-MS, Affinity Capture-Western, Far Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, far western blotting, mass spectrometry studies of complexes, pull down	direct interaction, physical, physical association	21664272, 9233798, (Europe PMC)	0.67	BioGRID, IntAct
NFKBIA	Phenotypic Suppression	genetic	12151397, (Europe PMC)	NA	BioGRID
NTRK1	Affinity Capture-MS	physical	25921289, (Europe PMC)	NA	BioGRID
OLIG1	Two-hybrid, two hybrid array, validated two hybrid	physical, physical association	25814554, (Europe PMC)	0.49	BioGRID, IntAct
PDGFRA	Affinity Capture-Western	physical	7682895, (Europe PMC)	NA	BioGRID
PDGFRB	Affinity Capture-Western, coimmunoprecipitation	association, physical	10697503, 11896619, 1314164, 1375321, 8382774, (Europe PMC)	0.64	BioGRID, IntAct, MINT
PLCG1	Affinity Capture-Western, pull down	physical, physical association	8977179, 9020117, 9743338, (Europe PMC)	0.40	BioGRID, IntAct, MINT
PTK2B	Affinity Capture-Western, Reconstituted Complex	physical	10708762, 10713673, (Europe PMC)	NA	BioGRID
PXN	Affinity Capture-Western	physical	10092539, (Europe PMC)	NA	BioGRID
RACK1	Affinity Capture-Western, Reconstituted Complex	physical	11350068, (Europe PMC)	NA	BioGRID
SERPINA4	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SLC9A2	Reconstituted Complex	physical	10187839, (Europe PMC)	NA	BioGRID
SOCS1	Affinity Capture-Western	physical	18556463, (Europe PMC)	NA	BioGRID
SOCS3	Affinity Capture-Western, Reconstituted Complex, coimmunoprecipitation, pull down	association, physical	11331873, (Europe PMC)	0.46	BioGRID, IntAct, MINT
SPSB1	Affinity Capture-Western	physical	15713673, (Europe PMC)	NA	BioGRID
SRC	Affinity Capture-Western, Biochemical Activity	physical	11389730, 1717825, (Europe PMC)	NA	BioGRID
TRMT2A	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
XRCC6	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
YES1	Affinity Capture-Western	physical	1544885, (Europe PMC)	NA	BioGRID
ZAP70	Affinity Capture-Western	physical	7760813, (Europe PMC)	NA	BioGRID
ZNF579	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT

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Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
APC	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
AR	fluorescence polarization spectroscopy	direct interaction	24728074, (Europe PMC)	0.44	IntAct
ATF7	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
AURKA	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
BBS10	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
BCL10	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
BMPR1A	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
BUB1	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
CAPNS1	anti bait coimmunoprecipitation, competition binding	physical association	18761085, (Europe PMC)	0.52	IntAct, MINT
CAV1	protein array, pull down	association, direct interaction	15504032, 20808760, (Europe PMC)	0.59	IntAct, MINT
CD5	Affinity Capture-Western, pull down	association, physical	9603468, (Europe PMC)	0.35	BioGRID, IntAct, MINT
CDKN2A	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
DCC	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
DLC1	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, two hybrid, two hybrid array	physical association	19151751, 24412244, (Europe PMC)	0.71	IntAct, MINT
EGFR	Protein-peptide, Reconstituted Complex, protein array	direct interaction, physical	1385407, 16273093, 8647858, (Europe PMC)	0.44	BioGRID, IntAct, MINT
EIF1	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ERBB2	Protein-peptide, protein array, two hybrid array	direct interaction, physical, physical association	16273093, 24412244, (Europe PMC)	0.59	BioGRID, IntAct, MINT
ERBB3	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
ERBB4	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
EZH2	two hybrid	physical association	21900206, (Europe PMC)	0.37	IntAct, MINT
FYB1	pull down	association	22074159, (Europe PMC)	0.35	IntAct
GAB1	coimmunoprecipitation, fluorescence polarization spectroscopy	association, direct interaction	15574420, 24728074, (Europe PMC)	0.59	IntAct, MINT
HRAS	Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Reconstituted Complex, x-ray crystallography	direct interaction, physical	11389730, 26721396, 7628625, 9219684, (Europe PMC)	0.44	BioGRID, IntAct
IGF1R	Affinity Capture-Western, Reconstituted Complex, pull down	association, physical	7642582, (Europe PMC)	0.35	BioGRID, IntAct, MINT
INSR	Affinity Capture-Western, pull down	physical, physical association	1331107, 9593725, (Europe PMC)	0.40	BioGRID, IntAct, MINT
KHDRBS1	pull down	physical association	7537265, (Europe PMC)	0.40	IntAct
KIT	fluorescence polarization spectroscopy	direct interaction	24728074, (Europe PMC)	0.44	IntAct
MET	fluorescence polarization spectroscopy	direct interaction	24728074, (Europe PMC)	0.44	IntAct
MLH3	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
NCK1	Affinity Capture-MS, Affinity Capture-Western, Far Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, far western blotting, mass spectrometry studies of complexes, pull down	direct interaction, physical, physical association	21664272, 9233798, (Europe PMC)	0.67	BioGRID, IntAct
NRAS	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
OLIG1	Two-hybrid, two hybrid array, validated two hybrid	physical, physical association	25814554, (Europe PMC)	0.49	BioGRID, IntAct
PDGFRB	Affinity Capture-Western, coimmunoprecipitation	association, physical	10697503, 11896619, 1314164, 1375321, 8382774, (Europe PMC)	0.64	BioGRID, IntAct, MINT
PLCG1	Affinity Capture-Western, pull down	physical, physical association	8977179, 9020117, 9743338, (Europe PMC)	0.40	BioGRID, IntAct, MINT
PMS2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
PTPRJ	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
RB1	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
SDC2	coimmunoprecipitation	physical association	22471946, (Europe PMC)	0.40	IntAct
SERPINA4	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SMAD2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
SOCS3	Affinity Capture-Western, Reconstituted Complex, coimmunoprecipitation, pull down	association, physical	11331873, (Europe PMC)	0.46	BioGRID, IntAct, MINT
STK11	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
TERF2IP	anti tag coimmunoprecipitation	physical association	25531777, (Europe PMC)	0.40	IntAct
TRMT2A	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
TSC1	two hybrid	physical association	17355907, (Europe PMC)	0.37	IntAct
XRCC6	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ZNF579	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT

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Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
APC	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
AURKA	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
BBS10	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
BCL10	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
BMPR1A	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
BUB1	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
CAPNS1	anti bait coimmunoprecipitation, competition binding	physical association	18761085, (Europe PMC)	0.52	IntAct, MINT
CAV1	protein array, pull down	association, direct interaction	15504032, 20808760, (Europe PMC)	0.59	IntAct, MINT
CD5	Affinity Capture-Western, pull down	association, physical	9603468, (Europe PMC)	0.35	BioGRID, IntAct, MINT
CDKN2A	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
DCC	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
DLC1	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, two hybrid, two hybrid array	physical association	19151751, 24412244, (Europe PMC)	0.71	IntAct, MINT
EGFR	Protein-peptide, Reconstituted Complex, protein array	direct interaction, physical	1385407, 16273093, 8647858, (Europe PMC)	0.44	BioGRID, IntAct, MINT
EIF1	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ERBB2	Protein-peptide, protein array, two hybrid array	direct interaction, physical, physical association	16273093, 24412244, (Europe PMC)	0.59	BioGRID, IntAct, MINT
ERBB3	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
ERBB4	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
EZH2	two hybrid	physical association	21900206, (Europe PMC)	0.37	IntAct, MINT
GAB1	coimmunoprecipitation, fluorescence polarization spectroscopy	association, direct interaction	15574420, 24728074, (Europe PMC)	0.59	IntAct, MINT
IGF1R	Affinity Capture-Western, Reconstituted Complex, pull down	association, physical	7642582, (Europe PMC)	0.35	BioGRID, IntAct, MINT
INSR	Affinity Capture-Western, pull down	physical, physical association	1331107, 9593725, (Europe PMC)	0.40	BioGRID, IntAct, MINT
MLH3	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
NRAS	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
PDGFRB	Affinity Capture-Western, coimmunoprecipitation	association, physical	10697503, 11896619, 1314164, 1375321, 8382774, (Europe PMC)	0.64	BioGRID, IntAct, MINT
PLCG1	Affinity Capture-Western, pull down	physical, physical association	8977179, 9020117, 9743338, (Europe PMC)	0.40	BioGRID, IntAct, MINT
PMS2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
PTPRJ	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
RB1	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
SERPINA4	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SMAD2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
SOCS3	Affinity Capture-Western, Reconstituted Complex, coimmunoprecipitation, pull down	association, physical	11331873, (Europe PMC)	0.46	BioGRID, IntAct, MINT
STK11	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
TRMT2A	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
XRCC6	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ZNF579	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT

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Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
ABL1	Affinity Capture-Western	physical	1571536, (Europe PMC)	NA	BioGRID
ANXA6	Far Western, Reconstituted Complex	physical	10571081, (Europe PMC)	NA	BioGRID
APC	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
APP	Reconstituted Complex	physical	21832049, (Europe PMC)	NA	BioGRID
AR	fluorescence polarization spectroscopy	direct interaction	24728074, (Europe PMC)	0.44	IntAct
ARHGAP35	Affinity Capture-Western, Reconstituted Complex	physical	8189062, 8419471, 9034330, (Europe PMC)	NA	BioGRID
ATF7	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
AURKA	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
BBS10	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
BCL10	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
BMPR1A	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
BTRC	Phenotypic Suppression	genetic	12151397, (Europe PMC)	NA	BioGRID
BUB1	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
CAPNS1	anti bait coimmunoprecipitation, competition binding	physical association	18761085, (Europe PMC)	0.52	IntAct, MINT
CAV1	protein array, pull down	association, direct interaction	15504032, 20808760, (Europe PMC)	0.59	IntAct, MINT
CAV2	Affinity Capture-Western, Reconstituted Complex	physical	12091389, (Europe PMC)	NA	BioGRID
CD5	Affinity Capture-Western, pull down	association, physical	9603468, (Europe PMC)	0.35	BioGRID, IntAct, MINT
CDKN2A	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
CSK	Reconstituted Complex	physical	7544435, (Europe PMC)	NA	BioGRID
DCC	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
DLC1	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, two hybrid, two hybrid array	physical association	19151751, 24412244, (Europe PMC)	0.71	IntAct, MINT
DNAJA3	Affinity Capture-Western, Reconstituted Complex	physical	11116152, (Europe PMC)	NA	BioGRID
DOK1	Affinity Capture-Western, Protein-peptide, Reconstituted Complex	physical	10688886, 10799545, 10822173, 11551902, 15151996, 22974441, 9008161, 9478921, 9822717, (Europe PMC)	NA	BioGRID
DOK2	Affinity Capture-Western	physical	10822173, 9478921, (Europe PMC)	NA	BioGRID
EGFR	Protein-peptide, Reconstituted Complex, protein array	direct interaction, physical	1385407, 16273093, 8647858, (Europe PMC)	0.44	BioGRID, IntAct, MINT
EIF1	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
EPHB2	Affinity Capture-Western, Reconstituted Complex	physical	10644995, 9233798, (Europe PMC)	NA	BioGRID
EPHB3	Affinity Capture-Western, Reconstituted Complex	physical	9674711, (Europe PMC)	NA	BioGRID
ERBB2	Protein-peptide, protein array, two hybrid array	direct interaction, physical, physical association	16273093, 24412244, (Europe PMC)	0.59	BioGRID, IntAct, MINT
ERBB3	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
ERBB4	Protein-peptide, protein array	direct interaction, physical	16273093, (Europe PMC)	0.44	BioGRID, IntAct, MINT
EZH2	Two-hybrid	physical	21900206, (Europe PMC)	NA	BioGRID
EZH2	two hybrid	physical association	21900206, (Europe PMC)	0.37	IntAct, MINT
FGFR1	Reconstituted Complex	physical	8321198, (Europe PMC)	NA	BioGRID
FYB1	pull down	association	22074159, (Europe PMC)	0.35	IntAct
G3BP1	Affinity Capture-Western	physical	9632780, (Europe PMC)	NA	BioGRID
GAB1	coimmunoprecipitation, fluorescence polarization spectroscopy	association, direct interaction	15574420, 24728074, (Europe PMC)	0.59	IntAct, MINT
GRB2	Affinity Capture-Western	physical	12441060, (Europe PMC)	NA	BioGRID
HCK	Affinity Capture-Western, Reconstituted Complex	physical	7782336, (Europe PMC)	NA	BioGRID
HNRNPL	Affinity Capture-RNA	physical	28611215, (Europe PMC)	NA	BioGRID
HRAS	Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Reconstituted Complex, x-ray crystallography	direct interaction, physical	11389730, 26721396, 7628625, 9219684, (Europe PMC)	0.44	BioGRID, IntAct
HTT	Affinity Capture-Western, Reconstituted Complex	physical	9079622, (Europe PMC)	NA	BioGRID
IGF1R	Affinity Capture-Western, Reconstituted Complex, pull down	association, physical	7642582, (Europe PMC)	0.35	BioGRID, IntAct, MINT
INSR	Affinity Capture-Western, pull down	physical, physical association	1331107, 9593725, (Europe PMC)	0.40	BioGRID, IntAct, MINT
KDR	Affinity Capture-Western	physical	10319320, (Europe PMC)	NA	BioGRID
KHDRBS1	Affinity Capture-Western, Reconstituted Complex	physical	11604231, 1385407, 1545818, 8189062, 8419471, 9743338, (Europe PMC)	NA	BioGRID
KHDRBS1	pull down	physical association	7537265, (Europe PMC)	0.40	IntAct
KIT	fluorescence polarization spectroscopy	direct interaction	24728074, (Europe PMC)	0.44	IntAct
LCK	Biochemical Activity	physical	11389730, (Europe PMC)	NA	BioGRID
MAP4K4	Affinity Capture-Western	physical	10669731, (Europe PMC)	NA	BioGRID
MET	fluorescence polarization spectroscopy	direct interaction	24728074, (Europe PMC)	0.44	IntAct
MLH3	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
NCK1	Affinity Capture-MS, Affinity Capture-Western, Far Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, far western blotting, mass spectrometry studies of complexes, pull down	direct interaction, physical, physical association	21664272, 9233798, (Europe PMC)	0.67	BioGRID, IntAct
NFKBIA	Phenotypic Suppression	genetic	12151397, (Europe PMC)	NA	BioGRID
NRAS	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
NTRK1	Affinity Capture-MS	physical	25921289, (Europe PMC)	NA	BioGRID
OLIG1	Two-hybrid, two hybrid array, validated two hybrid	physical, physical association	25814554, (Europe PMC)	0.49	BioGRID, IntAct
PDGFRA	Affinity Capture-Western	physical	7682895, (Europe PMC)	NA	BioGRID
PDGFRB	Affinity Capture-Western, coimmunoprecipitation	association, physical	10697503, 11896619, 1314164, 1375321, 8382774, (Europe PMC)	0.64	BioGRID, IntAct, MINT
PLCG1	Affinity Capture-Western, pull down	physical, physical association	8977179, 9020117, 9743338, (Europe PMC)	0.40	BioGRID, IntAct, MINT
PMS2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
PTK2B	Affinity Capture-Western, Reconstituted Complex	physical	10708762, 10713673, (Europe PMC)	NA	BioGRID
PTPRJ	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
PXN	Affinity Capture-Western	physical	10092539, (Europe PMC)	NA	BioGRID
RACK1	Affinity Capture-Western, Reconstituted Complex	physical	11350068, (Europe PMC)	NA	BioGRID
RB1	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
SDC2	coimmunoprecipitation	physical association	22471946, (Europe PMC)	0.40	IntAct
SERPINA4	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SLC9A2	Reconstituted Complex	physical	10187839, (Europe PMC)	NA	BioGRID
SMAD2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
SOCS1	Affinity Capture-Western	physical	18556463, (Europe PMC)	NA	BioGRID
SOCS3	Affinity Capture-Western, Reconstituted Complex, coimmunoprecipitation, pull down	association, physical	11331873, (Europe PMC)	0.46	BioGRID, IntAct, MINT
SPSB1	Affinity Capture-Western	physical	15713673, (Europe PMC)	NA	BioGRID
SRC	Affinity Capture-Western, Biochemical Activity	physical	11389730, 1717825, (Europe PMC)	NA	BioGRID
STK11	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
TERF2IP	anti tag coimmunoprecipitation	physical association	25531777, (Europe PMC)	0.40	IntAct
TRMT2A	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
TSC1	two hybrid	physical association	17355907, (Europe PMC)	0.37	IntAct
XRCC6	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
YES1	Affinity Capture-Western	physical	1544885, (Europe PMC)	NA	BioGRID
ZAP70	Affinity Capture-Western	physical	7760813, (Europe PMC)	NA	BioGRID
ZNF579	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT

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RASA1