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KEGG Pathway - Ras signaling pathway - Homo sapiens (human) Name UniProt AC Dephosphorylates following protein substrates: Dephosphorylates following non-protein substrates: PTPN11 Q06124 SPRY2 , SPRY1 , JAK2 , MPZL1 , EGFR , PDGFRB , SRC , SELE , IRS1 , KDR , STAT1 , STAT5A , PXN , STAT5B , SIRPA , ARHGAP5 , GAB1 , PTK2B , PAG1 , GAB2 , MAP3K4 , ERBB2 , LCK , CD28 , ERBB2 , PDCD1 , ERBB4 , Non-protein substrates of this phosphatase are not reported yet
Name UniProt AC Dephosphorylated by: IKBKB O14920 PPP2CA , PPP2CB , PPM1A , PPM1B , PPM1M , CHUK O15111 PPP2CA , PPP2CB , LAT O43561 ACP1 , PTPN1 , PTPRJ , ABL1 P00519 PTPN18 , PTPN12 , EGFR P00533 CDC25A , ACP1 , PTPN1 , PTPN9 , PTPRU , PTPRJ , PTPRK , PTPRS , PTPN6 , PTPN11 , PTPN2 , DUSP3 , UBASH3B , PTPRA , PTPRB , PTPN12 , PTPRH , RAF1 P04049 CDC25A , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPP5C , PTPN1 , NTRK1 P04629 PTPRZ1 , PTPRS , PTPN6 , PRKCB P05771 PHLPP1 , PHLPP2 , PPP1CA , PPP2CA , PPP2CB , INSR P06213 PTPRF , ACP1 , PTPN1 , PTPRE , PTPN2 , DUSP3 , IGF1R P08069 PTPN1 , MET P08581 PTPRF , PTPN1 , PTPRB , PTPRJ , PTPN2 , PDGFRB P09619 ACP1 , PTEN , PTPN1 , PTPRJ , PTPN11 , PTPN2 , DUSP3 , KIT P10721 PTPN6 , PRKCA P17252 PHLPP1 , PHLPP2 , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PRKACA P17612 PPP2CA , PPP2CB , PLCG1 P19174 PTPN1 , PTPRJ , ELK1 P19419 PPP3CA , PPP3CB , PPP3CC , RASA1 P20936 PTPN1 , FGFR2 P21802 DUSP3 , MAPK3 P27361 CDC25A , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP9 , DUSP23 , PTPRE , PTPRJ , DUSP3 , PPP2CA , PTPRR , DUSP14 , PIK3R1 P27986 PPM1A , PTPRJ , MAPK1 P28482 CDC25A , DUSP22 , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP6 , DUSP9 , DUSP7 , DUSP2 , PPP2CA , PPP2CB , PTPRE , PTPRJ , DUSP3 , PTPRR , SHC1 P29353 PTEN , PTPN2 , AKT1 P31749 ACP1 , PHLPP1 , PHLPP2 , PPP2CA , PPP2CB , PPP1CA , PPP1CB , PPP1CC , CTDSP1 , AKT2 P31751 PHLPP1 , PHLPP2 , KDR P35968 ACP1 , PTPRB , PTPRJ , PTPN6 , PTPN11 , PTPN2 , ZAP70 P43403 ACP1 , PTPN22 , UBASH3B , MAPK8 P45983 DUSP22 , DUSP8 , DUSP18 , DUSP1 , DUSP9 , DUSP10 , PPP2CA , PPP2CB , DUSP3 , MAPK9 P45984 DUSP19 , DUSP1 , DUSP4 , DUSP9 , DUSP10 , DUSP16 , DUSP3 , DUSP14 , MAPK10 P53779 DUSP16 , GNB1 P62873 PHPT1 , MAP2K1 Q02750 PPP2CA , PPP2CB , TEK Q02763 PTPRB , RELA Q04206 PPP2CA , PPP4C , PPP2CB , PTPN11 Q06124 PTPN1 , STK4 Q13043 PHLPP1 , PHLPP2 , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PAK1 Q13153 PPM1F , PPM1E , PPP2CA , PPP2CB , PPM1A , PAK2 Q13177 PPM1A , GAB1 Q13480 PTPN1 , PTPN11 , NTRK2 Q16620 PTPRS , KSR2 Q6VAB6 PPP3CA , PPP3CB , PPP3CC , BAD Q92934 ALPL , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPP3CA , PPP3CB , PPP3CC , PPM1B , PPP5C , GAB2 Q9UQC2 PTPN6 , PTPN11 , AKT3 Q9Y243 PHLPP1 , PHLPP2 , PPP2CA , PPP2CB ,
ChEBI ID KEGG ID ChEBIasciiName Molecule Dephosphorylated by: CHEBI:16595 C01245 1D-myo-inositol 1,4,5-trisphosphate INPP5B , INPP5A , INPP5E , INPP5J , INPP5K , OCRL , SYNJ1 , SYNJ2 , CHEBI:16618 C05981 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate TNS2 , FIG4 , INPP5B , INPP5E , INPP5K , OCRL , PTEN , PTPRQ , INPP5F , INPP5D , INPPL1 , SYNJ1 , SYNJ2 , TPTE2 ,