Top
PTPRR
Download FASTA sequences of PTPRR-substrates in Humans
Pathway ID Pathway Name Pathway Description (KEGG) hsa04010 MAPK signaling pathway The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Visualize    Download
Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ALDH18A1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID CBS Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CCT8L1P Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CEP290 Affinity Capture-MS physical 26638075 , (Europe PMC )NA BioGRID DHPS Affinity Capture-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID DNAJC13 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID EGFR Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID EPHA2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB2 Affinity Capture-Western, Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB3 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB4 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID FGFR2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID FGFR4 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID HNRNPL Affinity Capture-RNA physical 28611215 , (Europe PMC )NA BioGRID HSPA4L Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID IGF1R Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID INSR Affinity Capture-Western, Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID KDR Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID LMTK2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID MAD2L1BP Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MAPK1 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, fluorescence microscopy, phosphatase assay, proximity ligation assay, two hybrid array, two hybrid prey pooling approach colocalization, physical, physical association 10419510 , 10601328 , 25241761 , 26186194 , 27880917 , 28514442 , 9857190 , , (Europe PMC )0.49, 0.62 BioGRID, IntAct, MINT MAPK11 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MAPK14 Affinity Capture-MS, fluorescence microscopy, isothermal titration calorimetry, molecular sieving, nuclear magnetic resonance, phosphatase assay, pull down, x ray scattering colocalization, direct interaction, physical, physical association 10601328 , 23932588 , 26186194 , 27432908 , 27880917 , 28514442 , (Europe PMC )0.56, 0.65 BioGRID, IntAct, MINT MAPK1IP1L Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MAPK3 Affinity Capture-MS, Reconstituted Complex physical 10419510 , 27880917 , 9857190 , (Europe PMC )NA BioGRID MAPK7 Affinity Capture-Western, Reconstituted Complex physical 12042304 , (Europe PMC )NA BioGRID MAPKAPK3 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MST1R Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID NTRK1 Affinity Capture-MS, Two-hybrid physical 25921289 , 28065597 , (Europe PMC )NA BioGRID PNMA2 Affinity Capture-MS, Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PTK7 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID PTPRR Affinity Capture-MS, tox-r dimerization assay association, physical 15978577 , 27432908 , (Europe PMC )0.31 BioGRID, IntAct, MINT RET Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ROR1 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ROR2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID RYK Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID SNX6 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID TBC1D5 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID TEK Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID TRIM11 Affinity Capture-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID WASHC5 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID
Visualize    Download
Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source MAPK1 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, fluorescence microscopy, phosphatase assay, proximity ligation assay, two hybrid array, two hybrid prey pooling approach colocalization, physical, physical association 10419510 , 10601328 , 25241761 , 26186194 , 27880917 , 28514442 , 9857190 , , (Europe PMC )0.49, 0.62 BioGRID, IntAct, MINT MAPK14 Affinity Capture-MS, fluorescence microscopy, isothermal titration calorimetry, molecular sieving, nuclear magnetic resonance, phosphatase assay, pull down, x ray scattering colocalization, direct interaction, physical, physical association 10601328 , 23932588 , 26186194 , 27432908 , 27880917 , 28514442 , (Europe PMC )0.56, 0.65 BioGRID, IntAct, MINT PDGFRB phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct PTPRR Affinity Capture-MS, tox-r dimerization assay association, physical 15978577 , 27432908 , (Europe PMC )0.31 BioGRID, IntAct, MINT
Visualize    Download
Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source MAPK14 Affinity Capture-MS, fluorescence microscopy, isothermal titration calorimetry, molecular sieving, nuclear magnetic resonance, phosphatase assay, pull down, x ray scattering colocalization, direct interaction, physical, physical association 10601328 , 23932588 , 26186194 , 27432908 , 27880917 , 28514442 , (Europe PMC )0.56, 0.65 BioGRID, IntAct, MINT PTPRR Affinity Capture-MS, tox-r dimerization assay association, physical 15978577 , 27432908 , (Europe PMC )0.31 BioGRID, IntAct, MINT
Visualize    Download
Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ALDH18A1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID CBS Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CCT8L1P Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CDH2 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct CEP290 Affinity Capture-MS physical 26638075 , (Europe PMC )NA BioGRID DHPS Affinity Capture-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID DNAJC13 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID EGFR Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID EPHA2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB2 Affinity Capture-Western, Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB3 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ERBB4 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID FGFR2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID FGFR4 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID HNRNPL Affinity Capture-RNA physical 28611215 , (Europe PMC )NA BioGRID HSPA4L Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID IGF1R Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID INSR Affinity Capture-Western, Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID KDR Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID LMTK2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID MAD2L1BP Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MAPK1 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, fluorescence microscopy, phosphatase assay, proximity ligation assay, two hybrid array, two hybrid prey pooling approach colocalization, physical, physical association 10419510 , 10601328 , 25241761 , 26186194 , 27880917 , 28514442 , 9857190 , , (Europe PMC )0.49, 0.62 BioGRID, IntAct, MINT MAPK11 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MAPK14 Affinity Capture-MS, fluorescence microscopy, isothermal titration calorimetry, molecular sieving, nuclear magnetic resonance, phosphatase assay, pull down, x ray scattering colocalization, direct interaction, physical, physical association 10601328 , 23932588 , 26186194 , 27432908 , 27880917 , 28514442 , (Europe PMC )0.56, 0.65 BioGRID, IntAct, MINT MAPK1IP1L Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MAPK3 Affinity Capture-MS, Reconstituted Complex physical 10419510 , 27880917 , 9857190 , (Europe PMC )NA BioGRID MAPK7 Affinity Capture-Western, Reconstituted Complex physical 12042304 , (Europe PMC )NA BioGRID MAPKAPK3 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MST1R Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID NTRK1 Affinity Capture-MS, Two-hybrid physical 25921289 , 28065597 , (Europe PMC )NA BioGRID PDGFRB phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct PNMA2 Affinity Capture-MS, Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PTK7 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID PTPRR Affinity Capture-MS, tox-r dimerization assay association, physical 15978577 , 27432908 , (Europe PMC )0.31 BioGRID, IntAct, MINT RET Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ROR1 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID ROR2 Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID RYK Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID SNX6 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID TBC1D5 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID TEK Two-hybrid physical 28065597 , (Europe PMC )NA BioGRID TRIM11 Affinity Capture-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID WASHC5 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID
Phosphorylating Kinases Phosphoresidues Detection Method PubMed IDs Source
Visualize a network of protein kinases and phosphatases phosphorylating and dephosphorylating this protein respectively
MAPK1 T116_LPIPAANtIVVTLQM , T361_EPFVSIPtPREKVAM , in vitro 11493009 ,(Europe PMC )HPRD, MAPK3 T116_LPIPAANtIVVTLQM , T361_EPFVSIPtPREKVAM , in vitro 11493009 ,(Europe PMC )HPRD, PRKACA S339_GLQERRGsNVSLTLD , S94_RPAYDPSsNLLAMDG , in vitro 10601328 ,(Europe PMC )HPRD, Unknown Y125_VVTLQMDyNKLNITL , Y370_REKVAMEyLQSASRI , HTP, in vivo 18083107 ,(Europe PMC )HPRD, PhosphoELM ,