Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
299 KEGG pathways;
876 Reactome pathways;
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023


Human Phosphatases

Superfamily Family CATH code Relationship with historical class
Class I Cys-based PTPs (former Family 1) View tree DSP Class I Cys-based PTPs
Class II Cys-based PTPs (former Family 2) LMWPTP Class II Cys-based PTPs
Class III Cys-based PTPs (former Family 3) CDC25 Class III Cys-based PTPs
PPPL (former Family 5) View tree PPP PPP
NA Purple acid phosphatase

Vacuolar protein sorting 29 (VPS29) family

5'-nucleotidase family

PPM (former Family 6) View tree NA PP2C
HAD (former Family 7) View tree FCP FCP/SCP
Lipin family Lipin family

Asp-based PTPs

NA 5'(3')-deoxyribonucleotidase

DNA 3' phosphatase

HAD-like hydrolase

Pyrimidine 5'-nucleotidase family

5'-nucleotidase type 3

SerB family

Epoxide hydrolase family

eukaryotic PMM family

Histidine phosphatase (HP) (former Family 8) View tree PGAM Phosphoglycerate mutase
PFKFB Phosphoglycerate mutase
Histidine acid phosphatase Histidine acid phosphatase
NA Multiple inositol-polyphosphate phosphatase
Alkaline phosphatase (AP) (former Family 9) NA 3.40.720.10 Alkaline phosphatase
Adenosine/fructose/inositol-x-phosphatases (AFIxP) (former Family 10) View tree NA 3.30.540.10,

FBPase class 1

Inositol monophosphatase

Inositol-5-phosphatases (IP) (former Family 11) View tree NA Inositol-1,4,5-trisphosphate 5-phosphatase
Glucose/Lipid phosphatases (GLPs) (former Family 12) View tree NA

Glucose-6-phosphatase (Glc-6-Pase)

Phosphatidic acid phosphatase (PAP)

Type 2 lipid phosphate phosphatase

SAC domain phosphatases (former Family 13) NANA SAC domain family
Inositol-4-phosphatases (former Family 15) NANA Inositol-3,4-bisphosphate 4-phosphatase
PHP (former Family 16) NANA Janus family
RPAP (former Family 17) NANA RNA polymerase II-associated protein 2 (RPAP2)
SSU72 (former Family 18) NANA SSU72 phosphatase