Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
DEPOD - Phosphatase Search Result
Search results for EC number - 3.1.3.48
Download FASTA sequences in txt format
| Entry name | UniProt AC | Historic Class | SCOP Fold | EC number | CATH ID | Superfamily | Family | Activity status |
| ACP1 | P24666 | Class II Cys-based PTPs -> LMWPTP | CC2 | 3.1.3.2, 3.1.3.48 | 3.40.50.2300 | Class II Cys-based PTPs | LMWPTP | active |
| CDC14A | Q9UNH5 | Class I Cys-based PTPs --> VH1-like or DSPs --> CDC14s | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| CDC14B | O60729 | Class I Cys-based PTPs --> VH1-like or DSPs --> CDC14s | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| CDC14C | A4D256 | Class I Cys-based PTPs --> VH1-like or DSPs --> CDC14s | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| CDC25A | P30304 | Class III Cys-based PTPs --> CDC25s | CC3 | 3.1.3.48 | 3.40.250.10 | Class III Cys-based PTPs | CDC25 | active |
| CDC25B | P30305 | Class III Cys-based PTPs --> CDC25s | CC3 | 3.1.3.48 | 3.40.250.10 | Class III Cys-based PTPs | CDC25 | active |
| CDC25C | P30307 | Class III Cys-based PTPs --> CDC25s | CC3 | 3.1.3.48 | 3.40.250.10 | Class III Cys-based PTPs | CDC25 | active |
| CDKN3 | Q16667 | Class I Cys-based PTPs --> VH1-like or DSPs --> CDC14s | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DNAJC6 | O75061 | Class I Cys-based PTPs --> VH1-like or DSPs --> PTENs | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUPD1 | Q68J44 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP1 | P28562 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP10 | Q9Y6W6 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP12 | Q9UNI6 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP13 | Q6B8I1 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP13 | Q9UII6 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP14 | O95147 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP15 | Q9H1R2 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP16 | Q9BY84 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP18 | Q8NEJ0 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP19 | Q8WTR2 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP2 | Q05923 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP21 | Q9H596 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP22 | Q9NRW4 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP23 | Q9BVJ7 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP26 | Q9BV47 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP28 | Q4G0W2 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP3 | P51452 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP4 | Q13115 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP5 | Q16690 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP6 | Q16828 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP7 | Q16829 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP8 | Q13202 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| DUSP9 | Q99956 | Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| EPM2A | O95278 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| EYA1 | Q99502 | Asp-based PTPs --> EYAs | HAD | 3.1.3.48 | 3.40.50.12350 | HAD | EYA | active |
| EYA2 | O00167 | Asp-based PTPs --> EYAs | HAD | 3.1.3.48 | 3.40.50.12350 | HAD | EYA | active |
| EYA3 | Q99504 | Asp-based PTPs --> EYAs | HAD | 3.1.3.48 | 3.40.50.12350 | HAD | EYA | active |
| EYA4 | O95677 | Asp-based PTPs --> EYAs | HAD | 3.1.3.48 | 3.40.50.12350 | HAD | EYA | active |
| MDP1 | Q86V88 | HAD-like hydrolase | HAD | 3.1.3.-, 3.1.3.48 | 3.40.50.1000 | HAD | NA | active |
| MTMR3 | Q13615 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| MTMR4 | Q9NYA4 | Class I Cys-based PTPs --> VH1-like or DSPs --> Myotubularins | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| PTEN | P60484 | Class I Cys-based PTPs --> VH1-like or DSPs --> PTENs | CC1 | 3.1.3.16, 3.1.3.48, 3.1.3.67 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| PTP4A1 | Q93096 | Class I Cys-based PTPs --> VH1-like or DSPs --> PRLs | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| PTP4A2 | Q12974 | Class I Cys-based PTPs --> VH1-like or DSPs --> PRLs | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| PTP4A3 | O75365 | Class I Cys-based PTPs --> VH1-like or DSPs --> PRLs | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| PTPMT1 | Q8WUK0 | Class I Cys-based PTPs --> VH1-like or DSPs --> Atypical DSPs | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| PTPN1 | P18031 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN11 | Q06124 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN12 | Q05209 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN13 | Q12923 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN14 | Q15678 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN18 | Q99952 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN2 | P17706 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN20 | Q4JDL3 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | NA | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN21 | Q16825 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN22 | Q9Y2R2 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN23 | Q9H3S7 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN3 | P26045 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN4 | P29074 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN5 | P54829 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN6 | P29350 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN7 | P35236 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPN9 | P43378 | Class I Cys-based PTPs --> Classical PTPs --> Non-receptor type PTPs (NR-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | NR-PTP | active |
| PTPRA | P18433 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRB | P23467 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRC | P08575 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRD | P23468 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRE | P23469 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRF | P10586 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRG | P23470 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRH | Q9HD43 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRJ | Q12913 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRK | Q15262 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRM | P28827 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRN2 | Q92932 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRO | Q16827 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRQ | Q9UMZ3 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.-, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRR | Q15256 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRS | Q13332 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRT | O14522 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRU | Q92729 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| PTPRZ1 | P23471 | Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CC1 | 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | R-PTP | active |
| SSH1 | Q8WYL5 | Class I Cys-based PTPs --> VH1-like or DSPs --> Slingshots | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| SSH2 | Q76I76 | Class I Cys-based PTPs --> VH1-like or DSPs --> Slingshots | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| SSH3 | Q8TE77 | Class I Cys-based PTPs --> VH1-like or DSPs --> Slingshots | CC1 | 3.1.3.16, 3.1.3.48 | 3.90.190.10 | Class I Cys-based PTPs | DSP | active |
| UBASH3B | Q8TF42 | Phosphoglycerate mutase | HP | 3.1.3.48 | 3.40.50.1240 | histidine phosphatase (HP) | NA | active |