Top PTPN4
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade. TLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/interleukin-1-receptor (TIR)-domain-containing adapter protein) and MyD88, which leads to the NFkB activation and the induction of pro-inflammatory cytokines. The second pathway is activated by the adapters TRIF (TIR-domain-containing adapter protein inducing interferon-beta) and TRAM (TRIF-related adapter molecule). The combined use of TRIF and TRAM adapters is specific for TLR4 signaling pathway and leads to the induction of type I interferons and delayed activation of NFkB.The previous model of TLR4 signaling pathway described the simultaneous activation of these two signaling pathways at the plasma membrane, however the later studies suggested that upon activation TLR4 first induces TIRAP-MyD88 signaling at the plasma membrane and is then endocytosed and activates TRAM-TRIF signaling from the early endosome [Kagan JC et al 2008; Tanimura N et al 2008; Zanoni I et al 2011]
R-HSA-9008059 Interleukin-37 signaling. Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL37), also known as IL 1F7, is a member of the IL 1 family (Sharma et al. 2008). Isoform b of IL37 (referred just as IL37) is synthesized as a precursor that requires processing (primarily by caspase 1) to attain full receptor agonist or antagonist function (Kumar et al. 2002). Both full length and processed IL37 can bind to the IL 18 binding protein (IL 18BP) and the Interleukin 18 receptor 1 (IL 18R1) (Shi et al. 2003). Upon binding to the IL18R1, IL37 recruits Single Ig IL 1 related receptor (SIGIRR) (Nold-Petry et al. 2015). The IL37:IL18R1 complex can activate phosphorylation of Signal transducer and activator of transcription 3 (STAT3), Tyrosine protein kinase Mer and Phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN and can also inhibit Nuclear factor NF kappa B p105 subunit (NFKB) (Nold-Petry et al. 2015). Processed IL37 can be secreted from the cytosol to the extracellular space or translocated into the nucleus (Bulau et al. 2014). Full length IL37 can also be secreted from the cytosol to the extracellular space (Bulau et al. 2014). Processed IL37 can bind with Mothers against decapentaplegic homolog 3 (SMAD3) in the cytosol and then translocate to the nucleus, where it facilitates transcription of Tyrosine protein phosphatase non receptors (PTPNs) (Nold et al. 2010, Luo et al. 2017). These events ultimately lead to suppression of cytokine production in several types of immune cells resulting in reduced inflammation
Visualize Download
Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ATRX Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct C18orf25 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CADM1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID CRK Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, confocal microscopy, two hybrid colocalization, physical, physical association 21988832 , (Europe PMC )0.54 BioGRID, IntAct CRKL Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CSNK2A1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CSNK2A2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID EEF1A1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct EEF1G Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct GOLIM4 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID GRID2 Affinity Capture-Western, Two-hybrid physical 10748123 , (Europe PMC )NA BioGRID GRIN2A Affinity Capture-Western physical 10748123 , (Europe PMC )NA BioGRID HNRNPL Affinity Capture-RNA physical 28611215 , (Europe PMC )NA BioGRID KAT5 Reconstituted Complex, Two-hybrid, pull down, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.51 BioGRID, IntAct KCTD17 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID LPL Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct LTBP1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID MGMT Affinity Capture-MS physical 16226712 , (Europe PMC )NA BioGRID MPP7 Affinity Capture-MS, pull down association, physical 27880917 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct PAK4 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID PEX19 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID PTPN4 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SHKBP1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID SIRT1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SNRPD1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID TK1 Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT UNC13B Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID YWHAB Affinity Capture-MS, pull down association, physical 27432908 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct YWHAG Affinity Capture-MS, pull down association, physical 27432908 , 27880917 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct YWHAH Affinity Capture-MS, pull down association, physical 27432908 , 27880917 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct YWHAQ Affinity Capture-MS, pull down association, physical 27432908 , 27880917 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct YWHAZ Affinity Capture-MS, pull down association, physical 27432908 , 27880917 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct ZZEF1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct
Visualize Download
Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ATRX Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct CADM1 pull down association 28330616 , (Europe PMC )0.35 IntAct CAPRIN1 pull down association 28330616 , (Europe PMC )0.35 IntAct CRK Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, confocal microscopy, two hybrid colocalization, physical, physical association 21988832 , (Europe PMC )0.54 BioGRID, IntAct EEF1A1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct EEF1G Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct FYN peptide array physical association 17474147 , (Europe PMC )0.40 IntAct GRB2 peptide array physical association 17474147 , (Europe PMC )0.40 IntAct ICAM5 pull down association 28330616 , (Europe PMC )0.35 IntAct KAT5 Reconstituted Complex, Two-hybrid, pull down, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.51 BioGRID, IntAct LPL Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct MAPK12 enzymatic study dephosphorylation reaction 25158884 , (Europe PMC )0.44 IntAct, MINT MPP7 Affinity Capture-MS, pull down association, physical 27880917 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct NCK1 peptide array physical association 17474147 , (Europe PMC )0.40 IntAct PIK3R1 peptide array physical association 17474147 , (Europe PMC )0.40 IntAct SCML1 pull down association 28330616 , (Europe PMC )0.35 IntAct SRRM2 pull down association 28330616 , (Europe PMC )0.35 IntAct TK1 Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT TPR pull down association 28330616 , (Europe PMC )0.35 IntAct YWHAB Affinity Capture-MS, pull down association, physical 27432908 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct YWHAE pull down association 28330616 , (Europe PMC )0.35 IntAct YWHAG Affinity Capture-MS, pull down association, physical 27432908 , 27880917 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct YWHAH Affinity Capture-MS, pull down association, physical 27432908 , 27880917 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct YWHAQ Affinity Capture-MS, pull down association, physical 27432908 , 27880917 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct YWHAZ Affinity Capture-MS, pull down association, physical 27432908 , 27880917 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct ZZEF1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct
Visualize Download
Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ADH5 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID ATRX Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct C18orf25 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CADM1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID CADM1 pull down association 28330616 , (Europe PMC )0.35 IntAct CAPRIN1 pull down association 28330616 , (Europe PMC )0.35 IntAct CRK Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, confocal microscopy, two hybrid colocalization, physical, physical association 21988832 , (Europe PMC )0.54 BioGRID, IntAct CRKL Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CSNK2A1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID CSNK2A2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID EEF1A1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct EEF1G Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct FYN peptide array physical association 17474147 , (Europe PMC )0.40 IntAct GOLIM4 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID GRB2 peptide array physical association 17474147 , (Europe PMC )0.40 IntAct GRID2 Affinity Capture-Western, Two-hybrid physical 10748123 , (Europe PMC )NA BioGRID GRIN2A Affinity Capture-Western physical 10748123 , (Europe PMC )NA BioGRID HNRNPL Affinity Capture-RNA physical 28611215 , (Europe PMC )NA BioGRID ICAM5 pull down association 28330616 , (Europe PMC )0.35 IntAct KAT5 Reconstituted Complex, Two-hybrid, pull down, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.51 BioGRID, IntAct KCTD17 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID LPL Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct LTBP1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID MAPK12 enzymatic study dephosphorylation reaction 25158884 , (Europe PMC )0.44 IntAct, MINT MGMT Affinity Capture-MS physical 16226712 , (Europe PMC )NA BioGRID MPP7 Affinity Capture-MS, pull down association, physical 27880917 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct NCK1 peptide array physical association 17474147 , (Europe PMC )0.40 IntAct PAK4 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID PEX19 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID PIK3R1 peptide array physical association 17474147 , (Europe PMC )0.40 IntAct PTPN4 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SCML1 pull down association 28330616 , (Europe PMC )0.35 IntAct SHKBP1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID SIRT1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SNRPD1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID SRRM2 pull down association 28330616 , (Europe PMC )0.35 IntAct TK1 Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT TPR pull down association 28330616 , (Europe PMC )0.35 IntAct UNC13B Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID YWHAB Affinity Capture-MS, pull down association, physical 27432908 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct YWHAE pull down association 28330616 , (Europe PMC )0.35 IntAct YWHAG Affinity Capture-MS, pull down association, physical 27432908 , 27880917 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct YWHAH Affinity Capture-MS, pull down association, physical 27432908 , 27880917 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct YWHAQ Affinity Capture-MS, pull down association, physical 27432908 , 27880917 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct YWHAZ Affinity Capture-MS, pull down association, physical 27432908 , 27880917 , 28330616 , (Europe PMC )0.35 BioGRID, IntAct ZZEF1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct
Statistics
