Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
REACTOME Pathway - NA
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| PTPN2 | P17706 | WASL, EGFR, INSR, MET, PDGFRB, SRC, JAK1, SHC1, KDR, STAT3, STAT1, STAT6, STAT5A, STAT5B, JAK3, FKBP4, CAV1, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN4 | P29074 | CD247, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN6 | P29350 | JAK2, CTNND1, NFAT5, EGFR, ESR1, NTRK1, LCK, LYN, ROS1, KIT, ACTN1, SRC, CD33, CD22, NOS1, HOXA10, KDR, CASP8, GAB2, ERBB2, ERBB4, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN7 | P35236 | MAPK3, MAPK1, MAPK14, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN9 | P43378 | EGFR, ERBB2, NSF, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN5 | P54829 | FYN, BAK1, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN12 | Q05209 | PSTPIP1, ABL1, SRC, WAS, BCAR1, PTK2, PTK2B, EGFR, ERBB2, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN11 | Q06124 | SPRY2, SPRY1, JAK2, MPZL1, EGFR, PDGFRB, SRC, SELE, IRS1, KDR, STAT1, STAT5A, PXN, STAT5B, SIRPA, ARHGAP5, GAB1, PTK2B, PAG1, GAB2, MAP3K4, ERBB2, LCK, CD28, ERBB2, PDCD1, ERBB4, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN13 | Q12923 | MBP, NFKBIA, IRS1, TRIP6, PDCD10, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN14 | Q15678 | CTNNB1, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN20 | Q4JDL3 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| PTPN18 | Q99952 | PSTPIP1, ABL1, FYN, ARHGAP35, ERBB2, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN23 | Q9H3S7 | CDH1, SRC, CTNNB1, PTK2, | Non-protein substrates of this phosphatase are not reported yet |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| PTPN6 | P29350 | PTPN1, |
| PTPN7 | P35236 | PPP1CA, PPP1CB, PPP1CC, |
| STAT3 | P40763 | DUSP22, PTPN1, PTPRD, PTPRT, PTPN2, |
| SMAD3 | P84022 | MTMR4, PPP2CA, PPP2CB, PPM1A, CTDSP1, CTDSP2, CTDSPL, |
| PTPN11 | Q06124 | PTPN1, |