Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
299 KEGG pathways;
876 Reactome pathways;
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023




Gene Name PTPN6 (QuickGO)
Interactive visualization of PTPN6 structures
(A quick tutorial to explore the interctive visulaization)

Representative structure: 4GRY

SynonymsPTPN6, HCP, PTP1C
Protein NamePTPN6
Alternative Name(s)
Tyrosine-protein phosphatase non-receptor type 6;;Hematopoietic cell protein-tyrosine phosphatase;Protein-tyrosine phosphatase 1C;PTP-1C;Protein-tyrosine phosphatase SHP-1;SH-PTP1;
Protein FamilyBelongs to the protein-tyrosine phosphatase familyNon-receptor class 2 subfamily
EntrezGene ID5777   (Comparitive Toxicogenomics)
UniProt AC (Human)P29350 (protein sequence)
Enzyme Class3.1.3.48 (BRENDA )
Molecular Weight67561 Dalton
Protein Length595 amino acids (AA)
Genome Browsers NCBI | ENSG00000111679 (Ensembl) | UCSC
Crosslinking annotations Query our ID-mapping table
Orthologues Quest For Orthologues (QFO) | GeneTree | eggNOG - KOG0790 | eggNOG - COG5599
Phosphorylation Network Visualize
Domain organization, Expression, Diseases(show / hide)
Localization, Function, Catalytic activity and Sequence(show / hide)
Motif information from Eukaryotic Linear Motif atlas (ELM)(show / hide)
Gene Ontology (P: Process; F: Function and C: Component terms)(show / hide)