Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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KEGG Pathway - JAK-STAT signaling pathway - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| PTPN2 | P17706 | WASL, EGFR, INSR, MET, PDGFRB, SRC, JAK1, SHC1, KDR, STAT3, STAT1, STAT6, STAT5A, STAT5B, JAK3, FKBP4, CAV1, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN6 | P29350 | JAK2, CTNND1, NFAT5, EGFR, ESR1, NTRK1, LCK, LYN, ROS1, KIT, ACTN1, SRC, CD33, CD22, NOS1, HOXA10, KDR, CASP8, GAB2, ERBB2, ERBB4, | Non-protein substrates of this phosphatase are not reported yet |
| PTPN11 | Q06124 | SPRY2, SPRY1, JAK2, MPZL1, EGFR, PDGFRB, SRC, SELE, IRS1, KDR, STAT1, STAT5A, PXN, STAT5B, SIRPA, ARHGAP5, GAB1, PTK2B, PAG1, GAB2, MAP3K4, ERBB2, LCK, CD28, ERBB2, PDCD1, ERBB4, | Non-protein substrates of this phosphatase are not reported yet |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| JAK2 | O60674 | PTPRC, PTPN1, PTPN6, PTPN11, |
| STAM2 | O75886 | PTPN1, |
| EGFR | P00533 | CDC25A, ACP1, PTPN1, PTPN9, PTPRU, PTPRJ, PTPRK, PTPRS, PTPN6, PTPN11, PTPN2, DUSP3, UBASH3B, PTPRA, PTPRB, PTPN12, PTPRH, |
| MYC | P01106 | PPP2CA, PPP2CB, CTDSP1, |
| RAF1 | P04049 | CDC25A, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPP5C, PTPN1, |
| PDGFRB | P09619 | ACP1, PTEN, PTPN1, PTPRJ, PTPN11, PTPN2, DUSP3, |
| BCL2 | P10415 | PPP2CA, PPP2CB, |
| GHR | P10912 | PTPN1, PTPN3, |
| EPOR | P19235 | PTPN1, |
| JAK1 | P23458 | PTPRC, PTPN2, |
| PIK3R1 | P27986 | PPM1A, PTPRJ, |
| PTPN6 | P29350 | PTPN1, |
| TYK2 | P29597 | PTPRC, PTPN1, |
| AKT1 | P31749 | ACP1, PHLPP1, PHLPP2, PPP2CA, PPP2CB, PPP1CA, PPP1CB, PPP1CC, CTDSP1, |
| AKT2 | P31751 | PHLPP1, PHLPP2, |
| IL6ST | P40189 | PPP2CA, PPP2CB, |
| STAT3 | P40763 | DUSP22, PTPN1, PTPRD, PTPRT, PTPN2, |
| STAT1 | P42224 | PTPN11, PTPN2, |
| STAT6 | P42226 | PTPN1, PTPN2, |
| STAT5A | P42229 | ACP1, PTPN1, PTPN11, PTPN2, DUSP3, |
| STAT5B | P51692 | PTPN1, PTPN11, PTPN2, |
| JAK3 | P52333 | PTPRC, PTPN2, |
| PTPN11 | Q06124 | PTPN1, |
| AKT3 | Q9Y243 | PHLPP1, PHLPP2, PPP2CA, PPP2CB, |
| Non-protein substrates in this pathway |
Non-protein substrates involved in this pathway are unknown (yet!)