Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
299 KEGG pathways;
876 Reactome pathways;
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023




Gene Name PTEN (QuickGO)
Interactive visualization PTEN structures
(A quick tutorial to explore the interctive visulaization)

Synonyms PTEN, MMAC1, TEP1
Protein Name PTEN
Alternative Name(s)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;;;;Mutated in multiple advanced cancers 1;Phosphatase and tensin homolog;
EntrezGene ID5728   (Comparitive Toxicogenomics)
UniProt AC (Human) P60484 (protein sequence)
Enzyme ClassEC (BRENDA )
Molecular Weight47166 Dalton
Protein Length403 amino acids (AA)
Genome Browsers NCBI | ENSG00000171862 (Ensembl) | UCSC
Crosslinking annotations Query our ID-mapping table
Orthologues Quest For Orthologues (QFO) | GeneTree
Classification Superfamily: Class I Cys-based PTPs --> Family: DSP --> Subfamily: PTEN-like | Historic class: Class I Cys-based PTPs --> VH1-like or DSPs --> PTENs | CATH ID: | SCOP Fold: CC1
Phosphatase activityactive | Catalytic signature motif: HCKAGKGR
Phosphorylation Network Visualize
Domain organization, Expression, Diseases(show / hide)
Localization, Function, Catalytic activity and Sequence(show / hide)
Motif information from Eukaryotic Linear Motif atlas (ELM)(show / hide)
Gene Ontology (P: Process; F: Function and C: Component terms)(show / hide)