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KEGG Pathway - Cellular senescence - Homo sapiens (human) Name UniProt AC Dephosphorylates following protein substrates: Dephosphorylates following non-protein substrates: PPP3CB P16298 DNM1L , CRYAA , HSPB1 , JUN , MAPT , NEFH , PRKAR2A , ELK1 , FLNA , CANX , CSNK1E , GSK3B , VASP , DNM2 , RCAN1 , DNM1 , GAD2 , NFATC2 , PPP1R1A , SLC10A1 , KSR2 , SSH1 , BAD , GAD1 , PPP1R1B , TFEB , NFKBIA , LASP1 , Non-protein substrates of this phosphatase are not reported yet CDC25A P30304 EGFR , RAF1 , CDK1 , CDK4 , CDK2 , MAPK3 , MAPK1 , CUX1 , Non-protein substrates of this phosphatase are not reported yet PPP1CC P36873 FXYD1 , AURKA , AXIN1 , AHCYL1 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , CASP2 , TNNT2 , CSNK1E , HIST1H3A , CENPE , GAD2 , PTK2 , PRKCD , STK4 , STK3 , ATM , IKZF1 , CAMK2G , POLD3 , PRKD1 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , POLR2A , TTK , RYR2 , Non-protein substrates of this phosphatase are not reported yet PPP3CC P48454 DNM1L , CRYAA , HSPB1 , JUN , MAPT , NEFH , PRKAR2A , ELK1 , FLNA , CANX , CSNK1E , GSK3B , VASP , DNM2 , RCAN1 , DNM1 , GAD2 , NFATC2 , PPP1R1A , SLC10A1 , KSR2 , SSH1 , BAD , GAD1 , PPP1R1B , TFEB , NFKBIA , LASP1 , Non-protein substrates of this phosphatase are not reported yet PTEN P60484 PDGFRB , CREB1 , SHC1 , PTEN , PTK2 , PTK6 , 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate , 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate , 1D-myo-inositol 1,3,4,5-tetrakisphosphate , 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate , 1-phosphatidyl-1D-myo-inositol 3-phosphate , PPP1CA P62136 AURKA , AXIN1 , AHCYL1 , TBC1D4 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , PRKCB , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , EIF2AK2 , LMNB1 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , BRCA1 , CASP2 , TNNT2 , CSNK1E , CDK9 , CASP9 , PPP1CA , GAD2 , PTK2 , PRKCD , STK4 , STK3 , IKZF1 , CAMK2G , POLD3 , PRKD1 , PARD3 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , SF3B1 , POLR2A , RYR2 , SRSF1 , SLC6A3 , SENP3 , Non-protein substrates of this phosphatase are not reported yet PPP1CB P62140 AURKA , AXIN1 , AHCYL1 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , CASP2 , TNNT2 , CSNK1E , GAD2 , PTK2 , PRKCD , STK4 , STK3 , IKZF1 , CAMK2G , POLD3 , PRKD1 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , POLR2A , RYR2 , CDC5L , Non-protein substrates of this phosphatase are not reported yet PPP3CA Q08209 DNM1L , CRYAA , HSPB1 , JUN , MAPT , NEFH , PRKAR2A , ELK1 , FLNA , CANX , CSNK1E , GSK3B , VASP , DNM2 , RCAN1 , DNM1 , GAD2 , NFATC2 , PPP1R1A , SLC10A1 , KSR2 , SSH1 , BAD , GAD1 , PPP1R1B , TFEB , NFKBIA , LASP1 , TRPM3 , ORAI1 , Non-protein substrates of this phosphatase are not reported yet
Name UniProt AC Dephosphorylated by: CHEK1 O14757 PPP2CA , PPP2CB , PPM1D , CHEK2 O96017 PPP2CA , PPP2CB , PPM1D , MYC P01106 PPP2CA , PPP2CB , CTDSP1 , RAF1 P04049 CDC25A , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPP5C , PTPN1 , TP53 P04637 CDC14A , CDC14B , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPM1D , DUSP26 , RB1 P06400 PPP1CA , PPP1CB , PPP1CC , CTDSPL , PPP2CA , PPP2CB , CDK1 P06493 CDC25A , CDC25B , CDC25C , PPP2CA , PPP2CB , CDK4 P11802 CDC25A , CDK2 P24941 CDC25A , CDKN3 , PPP2CA , PPP2CB , PPM1A , PPM1B , MAPK3 P27361 CDC25A , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP9 , DUSP23 , PTPRE , PTPRJ , DUSP3 , PPP2CA , PTPRR , DUSP14 , PIK3R1 P27986 PPM1A , PTPRJ , MAPK1 P28482 CDC25A , DUSP22 , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP6 , DUSP9 , DUSP7 , DUSP2 , PPP2CA , PPP2CB , PTPRE , PTPRJ , DUSP3 , PTPRR , RBL1 P28749 PPP2CA , PPP2CB , CDC25A P30304 CDC14A , CDC14B , AKT1 P31749 ACP1 , PHLPP1 , PHLPP2 , PPP2CA , PPP2CB , PPP1CA , PPP1CB , PPP1CC , CTDSP1 , AKT2 P31751 PHLPP1 , PHLPP2 , TGFBR1 P36897 PPP1CC , PPP1CA , PPP1CB , MAPKAPK2 P49137 PPP2CA , PPP2CB , MAP2K6 P52564 PPM1A , MAPK12 P53778 PTPN3 , PTEN P60484 PTEN , PPP2CA , PPP1CA P62136 PPP1CA , SMAD3 P84022 MTMR4 , PPP2CA , PPP2CB , PPM1A , CTDSP1 , CTDSP2 , CTDSPL , CDK6 Q00534 PPM1A , PPM1B , MDM2 Q00987 PPP2CA , PPP2CB , PPM1D , MAP2K1 Q02750 PPP2CA , PPP2CB , RELA Q04206 PPP2CA , PPP4C , PPP2CB , RBL2 Q08999 PPP2CA , PPP2CB , ATM Q13315 PPP1CC , PPP2CA , PPP2CB , PPM1D , NFATC2 Q13469 PPP3CA , PPP3CB , PPP3CC , SMAD2 Q15796 PPM1A , CTDSP1 , CTDSP2 , CTDSPL , MAPK14 Q16539 DUSP22 , DUPD1 , PTPN7 , DUSP8 , DUSP1 , DUSP9 , DUSP10 , DUSP2 , PPP2CA , PPP2CB , PPM1A , PPM1D , DUSP26 , DUSP3 , DUSP14 , AKT3 Q9Y243 PHLPP1 , PHLPP2 , PPP2CA , PPP2CB ,
ChEBI ID KEGG ID ChEBIasciiName Molecule Dephosphorylated by: CHEBI:16618 C05981 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate TNS2 , FIG4 , INPP5B , INPP5E , INPP5K , OCRL , PTEN , PTPRQ , INPP5F , INPP5D , INPPL1 , SYNJ1 , SYNJ2 , TPTE2 ,
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