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TP53
Localization (UniProt annotation) Cytoplasm Nucleus Nucleus, PML bodyEndoplasmic reticulum Mitochondrion matrix Note=Interaction withBANP promotes nuclear localization Recruited into PML bodiestogether with CHEK2 Translocates to mitochondria upon oxidativestress Translocates to mitochondria in response to mitomycin Ctreatment (PubMed:27323408) Isoform 1: Nucleus CytoplasmNote=Predominantly nuclear but localizes to the cytoplasm whenexpressed with isoform 4 Isoform 2: Nucleus CytoplasmNote=Localized mainly in the nucleus with minor staining in thecytoplasm Isoform 3: Nucleus CytoplasmNote=Localized in the nucleus in most cells but found in thecytoplasm in some cells Isoform 4: Nucleus CytoplasmNote=Predominantly nuclear but translocates to the cytoplasmfollowing cell stress Isoform 7: Nucleus CytoplasmNote=Localized mainly in the nucleus with minor staining in thecytoplasm Isoform 8: Nucleus CytoplasmNote=Localized in both nucleus and cytoplasm in most cells Insome cells, forms foci in the nucleus that are different fromnucleoli Isoform 9: Cytoplasm Function (UniProt annotation) Acts as a tumor suppressor in many tumor types; inducesgrowth arrest or apoptosis depending on the physiologicalcircumstances and cell type Involved in cell cycle regulation asa trans-activator that acts to negatively regulate cell divisionby controlling a set of genes required for this process One ofthe activated genes is an inhibitor of cyclin-dependent kinasesApoptosis induction seems to be mediated either by stimulation ofBAX and FAS antigen expression, or by repression of Bcl-2expression In cooperation with mitochondrial PPIF is involved inactivating oxidative stress-induced necrosis; the function islargely independent of transcription Induces the transcription oflong intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1 LincRNA-p21 participates in TP53-dependent transcriptionalrepression leading to apoptosis and seems to have an effect oncell-cycle regulation Implicated in Notch signaling cross-overPrevents CDK7 kinase activity when associated to CAK complex inresponse to DNA damage, thus stopping cell cycle progressionIsoform 2 enhances the transactivation activity of isoform 1 fromsome but not all TP53-inducible promoters Isoform 4 suppressestransactivation activity and impairs growth suppression mediatedby isoform 1 Isoform 7 inhibits isoform 1-mediated apoptosisRegulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492) Catalytic Activity (UniProt annotation) N/A Protein Sequence MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAP
TPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAM
AIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKK
KPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
ELM Motif Motif Instance
Description Motif Regex DEG_MDM2_SWIB_1 19-FSDLWKLL-26 MDM2 binding motif F[^P]{3}W[^P]{2,3}[VIL] DOC_CYCLIN_1 381-KKLMF-385 Cyclin recognition site [RK].L.{0,1}[FYLIVMP] DOC_USP7_MATH_1 359-PGGSR-363 USP7 binding motif [PA][^P][^FYWIL]S[^P] DOC_USP7_MATH_1 364-AHSSH-368 USP7 binding motif [PA][^P][^FYWIL]S[^P] DOC_WW_Pin1_4 30-NVLSPL-35 WW domain ligands ...([ST])P. DOC_WW_Pin1_4 312-TSSSPQ-317 WW domain ligands ...([ST])P. DOC_WW_Pin1_4 78-AAPTPA-83 WW domain ligands ...([ST])P. MOD_CDK_SPxxK_3 312-TSSSPQPK-319 CDK Phosphorylation Site ...([ST])P..[RK] MOD_CK1_1 15-SQETFSD-21 CK1 Phosphorylation site S..([ST])... MOD_GSK3_1 30-NVLSPLPS-37 GSK3 phosphorylation site ...([ST])...[ST] MOD_PIKK_1 12-PPLSQET-18 PIKK phosphorylation site ...([ST])Q.. MOD_SUMO_for_1 385-FKTE-388 Sumoylation site [VILMAFP](K).E TRG_NES_CRM1_1 339-EMFRELNEALELKD-352 NES Nuclear Export Signal ([DEQ].{0,1}[LIM].{2,3}[LIVMF][^P]{2,3}[LMVF].[LMIV].{0,3}[DE])|([DE].{0,1}[LIM].{2,3}[LIVMF][^P]{2,3}[LMVF].[LMIV].{0,3}[DEQ]) TRG_NLS_Bipartite_1 305-KRALPNNTSSSPQPKKKPL-323 NLS classical Nuclear Localization Signals [KR][KR].{7,15}[^DE]((K[RK])|(RK))(([^DE][KR])|([KR][^DE]))[^DE]
TP53 is dephosphorylated by following phosphatases:
Phosphatase Gene Name Phosphatase UniProt_AC DephosphoSite and sequence (+/-5) in TP53 (P04637) Bioassay Type PubMed ID View in Europe PMC Reliability of the interaction PPP1CA P62136 Ser-15_VEPPLsQETFS, , Ser-37_LSPLPsQAMDD , In vitro and in vivo 15178317 , 16501611 , Europe PMC PPP1CB P62140 Ser-15_VEPPLsQETFS, , Ser-37_LSPLPsQAMDD , In vitro and in vivo 15178317 , 16501611 , Europe PMC PPP1CC P36873 Ser-15_VEPPLsQETFS, , Ser-37_LSPLPsQAMDD , In vitro and in vivo 15178317 , 16501611 , Europe PMC PPP2CA P67775 Ser-37_LSPLPsQAMDD, , Ser-46_DDLMLsPDDIE, , Thr-55_IEQWFtEDPGP , In vitro and in vivo 1848668 , 17245430 , 14712210 , Europe PMC PPP2CB P62714 Ser-37_LSPLPsQAMDD, , Ser-46_DDLMLsPDDIE, , Thr-55_IEQWFtEDPGP , In vitro and in vivo 1848668 , 17245430 , 14712210 , Europe PMC CDC14A Q9UNH5 Ser-315_NNTSSsPQPKK , In vitro and in vivo 10644693 , Europe PMC CDC14B O60729 Ser-315_NNTSSsPQPKK , In vitro and in vivo 10644693 , Europe PMC PPM1D O15297 Ser-15_VEPPLsQETFS , In vitro and in vivo 15870257 , Europe PMC DUSP26 Q9BV47 Ser-20_SQETFsDLWKL, , Ser-37_LSPLPsQAMDD , In vitro and in vivo 20562916 , Europe PMC
Pathway ID Pathway Name Pathway Description (KEGG) hsa01522 Endocrine resistance Endocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SERMs, e.g. tamoxifen), estrogen synthesis inhibitors (e.g. aromatase inhibitors (AIs) such as anastrozole, letrozole, and exemestane), and selective estrogen receptor down-regulators (SERDs, e.g. fulvestrant). However, resistance to these agents has become a major clinical obstacle. Mechanisms of endocrine resistance include loss of ER-alpha expression, altered expression of coactivators or coregulators that play a critical role in ER-mediated gene transcription, ligand-independent growth factor signaling cascades that activate kinases and ER-phosphorylation, altered availability of active tamoxifen metabolites regulated by drug-metabolizing enzymes, such as CYP2D6, and deregulation of the cell cycle and apoptotic machinery. hsa01524 Platinum drug resistance Platinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. The mechanism of action of Platinum-based drugs involves covalent binding to purine DNA bases, which primarily leads to cellular apoptosis. Their clinical success is, however, limited due to severe side effects and intrinsic or acquired resistance to the treatment. Platinum resistance could arise from decreased drug influx, increased drug efflux, intracellular detoxification by glutathione, etc., decreased binding (e.g., due to high intracellular pH), increased DNA repair, decreased mismatch repair, defective apoptosis, and altered oncogene expression. hsa04010 MAPK signaling pathway The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. hsa04071 Sphingolipid signaling pathway Sphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) and sphingosine-1-phosphate (S1P), have emerged as a new class of potent bioactive molecules. Ceramide can be generated de novo or by hydrolysis of membrane sphingomyelin by sphingomyelinase (SMase). Ceramide is subsequently metabolized by ceramidase to generate sphingosine (Sph) which in turn produces S1P through phosphorylation by sphingosine kinases 1 and 2 (SphK1, 2). Both ceramide and S1P regulate cellular responses to stress, with generally opposing effects. S1P functions as a growth and survival factor, acting as a ligand for a family of G protein-coupled receptors, whereas ceramide activates intrinsic and extrinsic apoptotic pathways through receptor-independent mechanisms. hsa04110 Cell cycle Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation. hsa04115 p53 signaling pathway p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways. hsa04137 Mitophagy - animal Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death. hsa04151 PI3K-Akt signaling pathway The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle. hsa04210 Apoptosis Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above. hsa04211 Longevity regulating pathway Regulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible strategy for extending lifespan. Four pathways have been implicated in mediating the CR effect. These are the insulin like growth factor (IGF-1)/insulin signaling pathway, the sirtuin pathway, the adenosine monophosphate (AMP) activated protein kinase (AMPK) pathway and the target of rapamycin (TOR) pathway. The collective response of these pathways to CR is believed to promote cellular fitness and ultimately longevity via activation of autophagy, stress defense mechanisms, and survival pathways while attenuating proinflammatory mediators and cellular growth. Furthermore, there is evidence supporting that life span extension can be achieved with pharmacologic agents that mimic the effects of caloric restriction, such as rapamycin, via mTOR signaling blockade, resveratrol, by activating SIRT1 activity, and metformin, which seems to be a robust stimulator of AMPK activity. As an aging suppressor, Klotho is an important molecule in aging processes and its overexpression results in longevity. hsa04216 Ferroptosis Ferroptosis is a regulated form of cell death and characterized by a production of reactive oxygen species (ROS) from accumulated iron and lipid peroxidation. It can be induced by experimental compounds (e.g.,erastin, RSL3) or clinical drugs(e.g., sulfasalazine, sorafenib) in cancer cell and certain normal cells. It is involved in multiple physiological and pathological processes, such as cancer cell death, neurodegenerative disease, tissue damage and acute renal failure. hsa04218 Cellular senescence Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing. hsa04310 Wnt signaling pathway Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. hsa04722 Neurotrophin signaling pathway Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory. hsa04919 Thyroid hormone signaling pathway The thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) and T3 enter the cell through transporter proteins. Although the major form of TH in the blood is T4, it is converted to the more active hormone T3 within cells. T3 binds to nuclear thyroid hormone receptors (TRs), which functions as a ligand-dependent transcription factor and controls the expression of target genes (genomic action). Nongenomic mechanisms of action is initiated at the integrin receptor. The plasma membrane alpha(v)beta(3)-integrin has distinct binding sites for T3 and T4. One binding site binds only T3 and activates the phosphatidylinositol 3-kinase (PI3K) pathway. The other binding site binds both T3 and T4 and activates the ERK1/2 MAP kinase pathway. hsa05014 Amyotrophic lateral sclerosis (ALS) Amyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord, leading to paralysis of voluntary muscles. Mutant superoxide dismutase 1 (SOD1), as seen in some familial ALS (FALS) cases, is unstable, forming aggregates in the motor neuron cytoplasm, axoplasm and mitochondria. Within mitochondria, mutant SOD1 may interfere with the anti-apoptotic function of Bcl-2, affect mitochondrial import by interfering with the translocation machinery (TOM/TIM), and generate toxic free radicals (ROS). Reactive oxygen species (ROS), produced within mitochondria, inhibit the function of EAAT2, the main glial glutamate transporter protein, responsible for most of the reuptake of synaptically released glutamate. Glutamate excess increases intracellular calcium, which enhances oxidative stress and mitochondrial damage. Mutant SOD1 can also trigger oxidative reactions , which can then cause damage through the formation of hydroxyl radicals or via nitration of tyrosine residues on proteins. Nitration may target neurofilament proteins, affecting axonal transport. Collectively, these mechanisms are predicted to disturb cellular homeostasis, ultimately triggering motor neuron death. hsa05016 Huntington disease Huntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality changes and dementia. HD is caused by a CAG repeat expansion in the IT15gene, which results in a long stretch of polyglutamine close to the amino-terminus of the HD protein huntingtin (Htt). Mutant Htt (mHtt) has effects both in the cytoplasm and in the nucleus. In the cytoplasm, full-length mHtt can interfere with BDNF vesicular transport on microtubules. This mutant protein also may lead to abnormal endocytosis and secretion in neurons, because normal Htt form a complex with the proteins Hip1, clathrin and AP2 that are involved in endocytosis. In addition, mHtt affects Ca2+ signaling by sensitizing InsP3R1 to activation by InsP3, stimulating NMDAR activity, and destabilizing mitochondrial Ca2+ handling. The mHtt translocates to the nucleus, where it forms intranuclear inclusions. Nuclear toxicity is believed to be caused by interference with gene transcription, leading to loss of transcription of neuroprotective molecules such as BDNF. While mHtt binds to p53 and upregulates levels of nuclear p53 as well as p53 transcriptional activity. Augmented p53 mediates mitochondrial dysfunction. hsa05160 Hepatitis C Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis. hsa05161 Hepatitis B Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis. hsa05162 Measles Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacterial infections. Several MV proteins have been suggested to disturb host immunity. After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems. Three proteins (P, V, and C) associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis. Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation. hsa05163 Human cytomegalovirus infection Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells. hsa05165 Human papillomavirus infection Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation. hsa05166 Human T-cell leukemia virus 1 infection Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, SRF, and NFAT. hsa05167 Kaposi sarcoma-associated herpesvirus infection Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies. hsa05168 Herpes simplex infection Herpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishment of latent infection in neuronal ganglia. HSV is the main cause of herpes infections that lead to the formation of characteristic blistering lesion. HSV express multiple viral accessory proteins that interfere with host immune responses and are indispensable for viral replication. Among these proteins, the immediate early (IE) gene ICP0, ICP4, and ICP27 are essential for regulation of HSV gene expression in productive infection. On the other hand, ORF P and ORF O gene are transcribed during latency and blocks the expression of the IE genes, thus maintaining latent infection. hsa05169 Epstein-Barr virus infection Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases. EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized. hsa05200 Pathways in cancer hsa05202 Transcriptional misregulation in cancer In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process. hsa05203 Viral carcinogenesis There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers. hsa05205 Proteoglycans in cancer Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR: 00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors. hsa05206 MicroRNAs in cancer MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article. hsa05210 Colorectal cancer Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined oncogenes and tumour suppressor genes (TSG). Two major mechanisms of genomic instability have been identified in sporadic CRC progression. The first, known as chromosomal instability (CIN), results from a series of genetic changes that involve the activation of oncogenes such as K-ras and inactivation of TSG such as p53, DCC/Smad4, and APC. The second, known as microsatellite instability (MSI), results from inactivation of the DNA mismatch repair genes MLH1 and/or MSH2 by hypermethylation of their promoter, and secondary mutation of genes with coding microsatellites, such as transforming growth factor receptor II (TGF-RII) and BAX. Hereditary syndromes have germline mutations in specific genes (mutation in the tumour suppressor gene APC on chromosome 5q in FAP, mutated DNA mismatch repair genes in HNPCC). hsa05212 Pancreatic cancer Infiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA). Normal duct epithelium progresses to infiltrating cancer through a series of histologically defined precursors (PanINs). The overexpression of HER-2/neu and activating point mutations in the K-ras gene occur early, inactivation of the p16 gene at an intermediate stage, and the inactivation of p53, SMAD4, and BRCA2 occur relatively late. Activated K-ras engages multiple effector pathways. Although EGF receptors are conventionally regarded as upstream activators of RAS proteins, they can also act as RAS signal transducers via RAS-induced autocrine activation of the EGFR family ligands. Moreover, PDA shows extensive genomic instability and aneuploidy. Telomere attrition and mutations in p53 and BRCA2 are likely to contribute to these phenotypes. Inactivation of the SMAD4 tumour suppressor gene leads to loss of the inhibitory influence of the transforming growth factor-beta signalling pathway. hsa05213 Endometrial cancer Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification. hsa05214 Glioma Gliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (astrocytomas), oligodendrocytes (oligodendrogliomas), mixtures of various glial cells (for example,oligoastrocytomas) and ependymal cells (ependymomas). The most malignant form of infiltrating astrocytoma - glioblastoma multiforme (GBM) - is one of the most aggressive human cancers. GBM may develop de novo (primary glioblastoma) or by progression from low-grade or anaplastic astrocytoma (secondary glioblastoma). Primary glioblastomas develop in older patients and typically show genetic alterations (EGFR amplification, p16/INK4a deletion, and PTEN mutations) at frequencies of 24-34%. Secondary glioblastomas develop in younger patients and frequently show overexpression of PDGF and CDK4 as well as p53 mutations (65%) and loss of Rb playing major roles in such transformations. Loss of PTEN has been implicated in both pathways, although it is much more common in the pathogenesis of primary GBM. hsa05215 Prostate cancer Prostate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. Androgen receptor (AR) is a transcription factor that is normally activated by its androgen ligand. During androgen withdrawal therapy, the AR signal transduction pathway also could be activated by amplification of the AR gene, by AR gene mutations, or by altered activity of AR coactivators. Through these mechanisms, tumor cells lead to the emergence of androgen-independent prostate cancer. hsa05216 Thyroid cancer Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells. Their behavior varies from the indolent growing, well-differentiated papillary and follicular carcinomas (PTC and FTC, respectively) to the extremely aggressive undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages. The most distinctive molecular features of FTC are the prominence of aneuploidy and the high prevalence of RAS mutations and PAX8-PPAR{gamma} rearrangements. p53 seems to play a crucial role in the dedifferentiation process of thyroid carcinoma. hsa05217 Basal cell carcinoma Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC. hsa05218 Melanoma Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes. The only known environmental risk factor is exposure to ultraviolet (UV) light and in people with fair skin the risk is greatly increased. Melanoma pathogenesis is also driven by genetic factors. Oncogenic NRAS mutations activate both effector pathways Raf-MEK-ERK and PI3K-Akt. The Raf-MEK-ERK pathway may also be activated via mutations in the BRAF gene. The PI3K-Akt pathway may be activated through loss or mutation of the inhibitory tumor suppressor gene PTEN. These mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Melanoma development has been shown to be strongly associated with inactivation of the p16INK4a/cyclin dependent kinases 4 and 6/retinoblastoma protein (p16INK4a/CDK4,6/pRb) and p14ARF/human double minute 2/p53 (p14ARF/HMD2/p53) tumor suppressor pathways. MITF and TP53 are implicated in further melanoma progression. hsa05219 Bladder cancer The urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carcinoma are bladder carcinomas, and urothelial carcinomas of the renal pelvis and ureter account for only approximately 7% of the total. Urothelial tumours arise and evolve through divergent phenotypic pathways. Some tumours progress from urothelial hyperplasia to low-grade non-invasive superficial papillary tumours. More aggressive variants arise either from flat, high-grade carcinoma in situ (CIS) and progress to invasive tumours, or they arise de novo as invasive tumours. Low-grade papillary tumors frequently show a constitutive activation of the receptor tyrosine kinase-Ras pathway, exhibiting activating mutations in the HRAS and fibroblast growth factor receptor 3 (FGFR3) genes. In contrast, CIS and invasive tumors frequently show alterations in the TP53 and RB genes and pathways. Invasion and metastases are promoted by several factors that alter the tumour microenvironment, including the aberrant expression of E-cadherins (E-cad), matrix metalloproteinases (MMPs), angiogenic factors such as vascular endothelial growth factor (VEGF). hsa05220 Chronic myeloid leukemia Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (CP), which is characterized by expansion of functionally normal myeloid cells, followed by an accelerated phase (AP) and finally a more aggressive blast phase (BP), with loss of terminal differentiation capacity. On the cellular level, CML is associated with a specific chromosome abnormality, the t(9; 22) reciprocal translocation that forms the Philadelphia (Ph) chromosome. The Ph chromosome is the result of a molecular rearrangement between the c-ABL proto-oncogene on chromosome 9 and the BCR (breakpoint cluster region) gene on chromosome 22. The BCR/ABL fusion gene encodes p210 BCR/ABL, an oncoprotein, which, unlike the normal p145 c-Abl, has constitutive tyrosine kinase activity and is predominantly localized in the cytoplasm. While fusion of c-ABL and BCR is believed to be the primary cause of the chronic phase of CML, progression to blast crisis requires other molecular changes. Common secondary abnormalities include mutations in TP53, RB, and p16/INK4A, or overexpression of genes such as EVI1. Additional chromosome translocations are also observed,such as t(3;21)(q26;q22), which generates AML1-EVI1. hsa05222 Small cell lung cancer Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control. hsa05223 Non-small cell lung cancer Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heterogeneous group of cancers, consisting mainly of squamous cell (SCC), adeno (AC) and large-cell carcinoma. Molecular mechanisms altered in NSCLC include activation of oncogenes, such as K-RAS, EGFR and EML4-ALK, and inactivation of tumorsuppressor genes, such as p53, p16INK4a, RAR-beta, and RASSF1. Point mutations within the K-RAS gene inactivate GTPase activity and the p21-RAS protein continuously transmits growth signals to the nucleus. Mutations or overexpression of EGFR leads to a proliferative advantage. EML4-ALK fusion leads to constitutive ALK activation, which causes cell proliferation, invasion, and inhibition of apoptosis. Inactivating mutation of p53 can lead to more rapid proliferation and reduced apoptosis. The protein encoded by the p16INK4a inhibits formation of CDK-cyclin-D complexes by competitive binding of CDK4 and CDK6. Loss of p16INK4a expression is a common feature of NSCLC. RAR-beta is a nuclear receptor that bears vitamin-A-dependent transcriptional activity. RASSF1A is able to form heterodimers with Nore-1, an RAS effector.Therefore loss of RASSF1A might shift the balance of RAS activity towards a growth-promoting effect. hsa05224 Breast cancer Breast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gland. The molecular subtypes of breast cancer, which are based on the presence or absence of hormone receptors (estrogen and progesterone subtypes) and human epidermal growth factor receptor-2 (HER2), include: hormone receptor positive and HER2 negative (luminal A subtype), hormone receptor positive and HER2 positive (luminal B subtype), hormone receptor negative and HER2 positive (HER2 positive), and hormone receptor negative and HER2 negative (basal-like or triple-negative breast cancers (TNBCs)). Hormone receptor positive breast cancers are largely driven by the estrogen/ER pathway. In HER2 positive breast tumours, HER2 activates the PI3K/AKT and the RAS/RAF/MAPK pathways, and stimulate cell growth, survival and differentiation. In patients suffering from TNBC, the deregulation of various signalling pathways (Notch and Wnt/beta-catenin), EGFR protein have been confirmed. In the case of breast cancer only 8% of all cancers are hereditary, a phenomenon linked to genetic changes in BRCA1 or BRCA2. Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers. hsa05225 Hepatocellular carcinoma Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways. hsa05226 Gastric cancer Gastric cancer (GC) is one of the world's most common cancers. According to Lauren's histological classification gastric cancer is divided into two distinct histological groups - the intestinal and diffuse types. Several genetic changes have been identified in intestinal-type GC. The intestinal metaplasia is characterized by mutations in p53 gene, reduced expression of retinoic acid receptor beta (RAR-beta) and hTERT expression. Gastric adenomas furthermore display mutations in the APC gene, reduced p27 expression and cyclin E amplification. In addition, amplification and overexpression of c-ErbB2, reduced TGF-beta receptor type I (TGFBRI) expression and complete loss of p27 expression are commonly observed in more advanced GC. The main molecular changes observed in diffuse-type GCs include loss of E-cadherin function by mutations in CDH1 and amplification of MET and FGFR2F. hsa05230 Central carbon metabolism in cancer Malignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamental differences in the central metabolic pathways operating in malignant tissue. He showed that cancer cells consume a large amount of glucose, maintain high rate of glycolysis and convert a majority of glucose into lactic acid even under normal oxygen concentrations (Warburg's Effects). More recently, it has been recognized that the 'Warburg effect' encompasses a similarly increased utilization of glutamine. From the intermediate molecules provided by enhanced glycolysis and glutaminolysis, cancer cells synthesize most of the macromolecules required for the duplication of their biomass and genome. These cancer-specific alterations represent a major consequence of genetic mutations and the ensuing changes of signalling pathways in cancer cells. Three transcription factors, c-MYC, HIF-1 and p53, are key regulators and coordinate regulation of cancer metabolism in different ways, and many other oncogenes and tumor suppressor genes cluster along the signaling pathways that regulate c-MYC, HIF-1 and p53. hsa05418 Fluid shear stress and atherosclerosis Shear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress of atherosclerosis. Sustained laminar flow with high shear stress upregulates expressions of endothelial cell (EC) genes and proteins that are protective against atherosclerosis. The key shear stress-induced transcription factors that govern the expression of these genes are Kruppel-like factor 2 (KLF2) and nuclear factor erythroid 2-like 2 (Nrf2). On the other hand, disturbed flow with associated reciprocating, low shear stress generally upregulates the EC genes and proteins that promote oxidative and inflammatory states in the artery wall, resulting in atherogenesis. Important transcriptional events that reflect this condition of ECs in disturbed flow include the activation of activator protein 1 (AP-1) and nuclear factor kappaB (NF-kappaB).
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-111448 Activation of NOXA and translocation to mitochondria. NOXA is transactivated in a p53-dependent manner and by E2F1. Activated NOXA is translocated to mitochondria R-HSA-139915 Activation of PUMA and translocation to mitochondria. Puma is transactivated in a p53-dependent manner and by E2F1. Activated Puma is translocated to mitochondria R-HSA-1912408 Pre-NOTCH Transcription and Translation. In humans, the NOTCH protein family has four members: NOTCH1, NOTCH2, NOTCH3 and NOTCH4. NOTCH1 protein was identified first, as the product of a chromosome 9 gene translocated in T-cell acute lymphoblastic leukemia that was homologous to Drosophila Notch (Ellisen et al. 1991). At the same time, rat Notch1 was cloned (Weinmaster et al. 1991), followed by cloning of mouse Notch1, named Motch (Del Amo et al. 1992). NOTCH2 protein is the product of a gene on chromosome 1 (Larsson et al. 1994). NOTCH2 expression is differentially regulated during B-cell development (Bertrand et al. 2000). NOTCH2 mutations are a rare cause of Alagille syndrome (McDaniell et al. 2006). NOTCH3 is the product of a gene on chromosome 19. NOTCH3 mutations are the underlying cause of CADASIL, cerebral arteriopathy with subcortical infarcts and leukoencephalopathy (Joutel et al. 1996). NOTCH4, the last NOTCH protein discovered, is the product of a gene on chromosome 6 (Li et al. 1998). MicroRNAs play an important negative role in translation and/or stability of NOTCH mRNAs. MicroRNAs miR-34 (miR-34A, miR-34B and mi-R34C), whose transcription is directly induced by the tumor suppressor protein p53 (Chang et al. 2007, Raver-Shapira et al. 2007, He et al. 2007, Corney et al. 2007) bind and negatively regulate translation of NOTCH1 mRNA (Li et al. 2009, Pang et al. 2010, Ji et al. 2009) and NOTCH2 mRNA (Li et al. 2009). NOTCH1 mRNA translation is also negatively regulated by microRNAs miR-200B and miR-200C (Kong et al. 2010), as well as miR-449A, miR-449B and miR-449C (Marcet et al. 2011). Translation of NOTCH3 mRNA is negatively regulated by microRNAs miR-150 (Ghisi et al. 2011) and miR-206 (Song et al. 2009). Translation of NOTCH4 mRNA is negatively regulated by microRNAs miR-181C (Hashimoto et al. 2010) and miR-302A (Costa et al. 2009). Nascent NOTCH peptides are co-translationally targeted to the endoplasmic reticulum for further processing, followed by modification in the Golgi apparatus, before trafficking to the plasma membrane. Endoplasmic reticulum calcium ATPases, positively regulate NOTCH trafficking, possibly by contributing to accurate folding of NOTCH precursors (Periz et al. 1999) R-HSA-2559580 Oxidative Stress Induced Senescence. Oxidative stress, caused by increased concentration of reactive oxygen species (ROS) in the cell, can happen as a consequence of mitochondrial dysfunction induced by the oncogenic RAS (Moiseeva et al. 2009) or independent of oncogenic signaling. Prolonged exposure to interferon-beta (IFNB, IFN-beta) also results in ROS increase (Moiseeva et al. 2006). ROS oxidize thioredoxin (TXN), which causes TXN to dissociate from the N-terminus of MAP3K5 (ASK1), enabling MAP3K5 to become catalytically active (Saitoh et al. 1998). ROS also stimulate expression of Ste20 family kinases MINK1 (MINK) and TNIK through an unknown mechanism, and MINK1 and TNIK positively regulate MAP3K5 activation (Nicke et al. 2005). MAP3K5 phosphorylates and activates MAP2K3 (MKK3) and MAP2K6 (MKK6) (Ichijo et al. 1997, Takekawa et al. 2005), which act as p38 MAPK kinases, as well as MAP2K4 (SEK1) (Ichijo et al. 1997, Matsuura et al. 2002), which, together with MAP2K7 (MKK7), acts as a JNK kinase.
MKK3 and MKK6 phosphorylate and activate p38 MAPK alpha (MAPK14) and beta (MAPK11) (Raingeaud et al. 1996), enabling p38 MAPKs to phosphorylate and activate MAPKAPK2 (MK2) and MAPKAPK3 (MK3) (Ben-Levy et al. 1995, Clifton et al. 1996, McLaughlin et al. 1996, Sithanandam et al. 1996, Meng et al. 2002, Lukas et al. 2004, White et al. 2007), as well as MAPKAPK5 (PRAK) (New et al. 1998 and 2003, Sun et al. 2007).
Phosphorylation of JNKs (MAPK8, MAPK9 and MAPK10) by MAP3K5-activated MAP2K4 (Deacon and Blank 1997, Fleming et al. 2000) allows JNKs to migrate to the nucleus (Mizukami et al. 1997) where they phosphorylate JUN. Phosphorylated JUN binds FOS phosphorylated by ERK1 or ERK2, downstream of activated RAS (Okazaki and Sagata 1995, Murphy et al. 2002), forming the activated protein 1 (AP-1) complex (FOS:JUN heterodimer) (Glover and Harrison 1995, Ainbinder et al. 1997).
Activation of p38 MAPKs and JNKs downstream of MAP3K5 (ASK1) ultimately converges on transcriptional regulation of CDKN2A locus. In dividing cells, nucleosomes bound to the CDKN2A locus are trimethylated on lysine residue 28 of histone H3 (HIST1H3A) by the Polycomb repressor complex 2 (PRC2), creating the H3K27Me3 (Me3K-28-HIST1H3A) mark (Bracken et al. 2007, Kotake et al. 2007). The expression of Polycomb constituents of PRC2 (Kuzmichev et al. 2002) - EZH2, EED and SUZ12 - and thereby formation of the PRC2, is positively regulated in growing cells by E2F1, E2F2 and E2F3 (Weinmann et al. 2001, Bracken et al. 2003). H3K27Me3 mark serves as a docking site for the Polycomb repressor complex 1 (PRC1) that contains BMI1 (PCGF4) and is therefore named PRC1.4, leading to the repression of transcription of p16-INK4A and p14-ARF from the CDKN2A locus, where PCR1.4 mediated repression of p14-ARF transcription in humans may be context dependent (Voncken et al. 2005, Dietrich et al. 2007, Agherbi et al. 2009, Gao et al. 2012). MAPKAPK2 and MAPKAPK3, activated downstream of the MAP3K5-p38 MAPK cascade, phosphorylate BMI1 of the PRC1.4 complex, leading to dissociation of PRC1.4 complex from the CDKN2A locus and upregulation of p14-ARF transcription (Voncken et al. 2005). AP-1 transcription factor, formed as a result of MAP3K5-JNK signaling, as well as RAS signaling, binds the promoter of KDM6B (JMJD3) gene and stimulates KDM6B expression. KDM6B is a histone demethylase that removes H3K27Me3 mark i.e. demethylates lysine K28 of HIST1H3A, thereby preventing PRC1.4 binding to the CDKN2A locus and allowing transcription of p16-INK4A (Agger et al. 2009, Barradas et al. 2009, Lin et al. 2012).
p16-INK4A inhibits phosphorylation-mediated inactivation of RB family members by CDK4 and CDK6, leading to cell cycle arrest (Serrano et al. 1993). p14-ARF inhibits MDM2-mediated degradation of TP53 (p53) (Zhang et al. 1998), which also contributes to cell cycle arrest in cells undergoing oxidative stress. In addition, phosphorylation of TP53 by MAPKAPK5 (PRAK) activated downstream of MAP3K5-p38 MAPK signaling, activates TP53 and contributes to cellular senescence (Sun et al. 2007)
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF). The process of DNA damage/telomere stress induced senescence culminates in the formation of senescence associated heterochromatin foci (SAHF). These foci represent facultative heterochromatin that is formed in senescent cells. They contribute to the repression of proliferation promoting genes and play an important role in the permanent cell cycle exit that characterizes senescence (Narita et al. 2003 and 2006). SAHF appear as compacted, punctate DAPI stained foci of DNA. Each chromosome is condensed into a single SAH focus, with telomeric and centromeric chromatin located predominantly at its periphery (Funayama et al. 2006, Zhang et al. 2007).An evolutionarily conserved protein complex of HIRA, ASF1A, UBN1 and CABIN1 plays a crucial role in the SAHF formation. As cells approach senescence, HIRA, ASF1A, UBN1 and CABIN1 accumulate at the PML bodies (Zhang et al. 2005, Banumathy et al. 2009, Rai et al. 2011). PML bodies are punctate nuclear structures that contain PML protein and numerous other proteins and are proposed to be the sites of assembly of macromolecular regulatory complexes and protein modification (Fogal et al. 2000, Guo et al. 2000, Pearson et al. 2000). Recruitment of HIRA to PML bodies coincides with altered chromatin structure and deposition of macroH2A histone H2A variant onto chromatin. As cells become senescent, HIRA, ASF1A, UBN1 and CABIN1 relocate from PML bodies to SAHF. HIRA accumulation at PML bodies is RB1 and TP53 independent, but may require phosphorylation of HIRA serine S697 by GSK3B (Ye, Zerlanko, Kennedy et al. 2007). SAHF formation itself, however, requires functional RB1 and TP53 pathways (Ye, Zerlanko, Zhang et al. 2007).
SAHF contain H3K9Me mark, characteristic of trancriptionally silent chromatin, and HP1, marcoH2A histone H2A variant and HMGA proteins are also components of SAHF (Narita et al. 2006), besides the HIRA:ASF1A:UBN1:CABIN1 complex. A yet unidentified H3K9Me histone methyltransferase may be recruited to SAHF by UBN1 (Banumathy et al. 2009). One of the functions of the HIRA:ASF1A:UBN1:CABIN1 complex is to deposit histone H3.3. variant to chromatin, which influences gene expression (Zhang et al. 2007, Rai et al. 2011).
Further studies are needed to fully elucidate the mechanism of SAHF formation and mechanism by which SAHF promote cell senescence
R-HSA-2559585 Oncogene Induced Senescence. Oncogene-induced senescence is triggered by high level of RAS/RAF/MAPK signaling that can be caused, for example, by oncogenic mutations in RAS or RAF proteins, or by oncogenic mutations in growth factor receptors, such as EGFR, that act upstream of RAS/RAF/MAPK cascade. Oncogene-induced senescence can also be triggered by high transcriptional activity of E2F1, E2F2 or E2F3 which can be caused, for example, by the loss-of-function of RB1 tumor suppressor.Oncogenic signals trigger transcription of CDKN2A locus tumor suppressor genes: p16-INK4A and p14-ARF. p16-INK4A and p14-ARF share exons 2 and 3, but are expressed from different promoters and use different reading frames (Quelle et al. 1995). Therefore, while their mRNAs are homologous and are both translationally inhibited by miR-24 microRNA (Lal et al. 2008, To et al. 2012), they share no similarity at the amino acid sequence level and perform distinct functions in the cell. p16-INK4A acts as the inhibitor of cyclin-dependent kinases CDK4 and CDK6 which phosphorylate and inhibit RB1 protein thereby promoting G1 to S transition and cell cycle progression (Serrano et al. 1993). Increased p16-INK4A level leads to hypophosphorylation of RB1, allowing RB1 to inhibit transcription of E2F1, E2F2 and E2F3-target genes that are needed for cell cycle progression, which results in cell cycle arrest in G1 phase. p14-ARF binds and destabilizes MDM2 ubiquitin ligase (Zhang et al. 1998), responsible for ubiquitination and degradation of TP53 (p53) tumor suppressor protein (Wu et al. 1993, Fuchs et al. 1998, Fang et al. 2000). Therefore, increased p14-ARF level leads to increased level of TP53 and increased expression of TP53 target genes, such as p21, which triggers p53-mediated cell cycle arrest and, depending on other factors, may also lead to p53-mediated apoptosis. CDKN2B locus, which encodes an inhibitor of CDK4 and CDK6, p15-INK4B, is located in the vicinity of CDKN2A locus, at the chromosome band 9p21. p15-INK4B, together with p16-INK4A, contributes to senescence of human T-lymphocytes (Erickson et al. 1998) and mouse fibroblasts (Malumbres et al. 2000). SMAD3, activated by TGF-beta-1 signaling, controls senescence in the mouse multistage carcinogenesis model through regulation of MYC and p15-INK4B gene expression (Vijayachandra et al. 2003). TGF-beta-induced p15-INK4B expression is also important for the senescence of hepatocellular carcinoma cell lines (Senturk et al. 2010).MAP kinases MAPK1 (ERK2) and MAPK3 (ERK1), which are activated by RAS signaling, phosphorylate ETS1 and ETS2 transcription factors in the nucleus (Yang et al. 1996, Seidel et al. 2002, Foulds et al. 2004, Nelson et al. 2010). Phosphorylated ETS1 and ETS2 are able to bind RAS response elements (RREs) in the CDKN2A locus and stimulate p16-INK4A transcription (Ohtani et al. 2004). At the same time, activated ERKs (MAPK1 i.e. ERK2 and MAPK3 i.e. ERK1) phosphorylate ERF, the repressor of ETS2 transcription, which leads to translocation of ERF to the cytosol and increased transcription of ETS2 (Sgouras et al. 1995, Le Gallic et al. 2004). ETS2 can be sequestered and inhibited by binding to ID1, resulting in inhibition of p16-INK4A transcription (Ohtani et al. 2004).Transcription of p14-ARF is stimulated by binding of E2F transcription factors (E2F1, E2F2 or E2F3) in complex with SP1 to p14-ARF promoter (Parisi et al. 2002).Oncogenic RAS signaling affects mitochondrial metabolism through an unknown mechanism, leading to increased generation of reactive oxygen species (ROS), which triggers oxidative stress induced senescence pathway. In addition, increased rate of cell division that is one of the consequences of oncogenic signaling, leads to telomere shortening which acts as another senescence trigger
R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence. Reactive oxygen species (ROS), whose concentration increases in senescent cells due to oncogenic RAS-induced mitochondrial dysfunction (Moiseeva et al. 2009) or due to environmental stress, cause DNA damage in the form of double strand breaks (DSBs) (Yu and Anderson 1997). In addition, persistent cell division fueled by oncogenic signaling leads to replicative exhaustion, manifested in critically short telomeres (Harley et al. 1990, Hastie et al. 1990). Shortened telomeres are no longer able to bind the protective shelterin complex (Smogorzewska et al. 2000, de Lange 2005) and are recognized as damaged DNA. The evolutionarily conserved MRN complex, consisting of MRE11A (MRE11), RAD50 and NBN (NBS1) subunits, binds DSBs (Lee and Paull 2005) and shortened telomeres that are no longer protected by shelterin (Wu et al. 2007). Once bound to the DNA, the MRN complex recruits and activates ATM kinase (Lee and Paull 2005, Wu et al. 2007), leading to phosphorylation of ATM targets, including TP53 (p53) (Banin et al. 1998, Canman et al. 1998, Khanna et al. 1998). TP53, phosphorylated on serine S15 by ATM, binds the CDKN1A (also known as p21, CIP1 or WAF1) promoter and induces CDKN1A transcription (El-Deiry et al. 1993, Karlseder et al. 1999). CDKN1A inhibits the activity of CDK2, leading to G1/S cell cycle arrest (Harper et al. 1993, El-Deiry et al. 1993).
SMURF2 is upregulated in response to telomere attrition in human fibroblasts and induces senecscent phenotype through RB1 and TP53, independently of its role in TGF-beta-1 signaling (Zhang and Cohen 2004). The exact mechanism of SMURF2 involvement is senescence has not been elucidated
R-HSA-3232118 SUMOylation of transcription factors. Proteins classified as transcription factors constitute a disproportionate number of SUMOylation targets. In most cases SUMOylation inhibits transcriptional activation, however in some cases such as TP53 (p53) SUMOylation can enhance activation. Inhibition of transcription by SUMOylation may be due to interference with DNA binding, re-localization to inactive nuclear bodies, or recruitment of repressive cofactors such as histone deacetylases (reviewed in Girdwood et al. 2004, Gill 2005) R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1. COP1 is one of several E3 ubiquitin ligases responsible for the tight regulation of p53 abundance. Following DNA damage, COP1 dissociates from p53 and is inactivated by autodegradation via a pathway involving ATM phosphorylation of COP1 on Ser(387), autoubiquitination and proteasome mediated degradation. Destruction of COP1 results in abrogation of the ubiquitination and degradation of p53 (Dornan et al., 2006) R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis. TRiC has broad recognition specificities, but in the cell it interacts with only a defined set of substrates (Yam et al. 2008). Many of its substrates that are targeted during biosynthesis are conserved between mammals and yeast (Yam et al. 2008) R-HSA-5628897 TP53 Regulates Metabolic Genes. While the p53 tumor suppressor protein (TP53) is known to inhibit cell growth by inducing apoptosis, senescence and cell cycle arrest, recent studies have found that p53 is also able to influence cell metabolism to prevent tumor development. TP53 regulates transcription of many genes involved in the metabolism of carbohydrates, nucleotides and amino acids, protein synthesis and aerobic respiration.TP53 stimulates transcription of TIGAR, a D-fructose 2,6-bisphosphatase. TIGAR activity decreases glycolytic rate and lowers ROS (reactive oxygen species) levels in cells (Bensaad et al. 2006). TP53 may also negatively regulate the rate of glycolysis by inhibiting the expression of glucose transporters GLUT1, GLUT3 and GLUT4 (Kondoh et al. 2005, Schwartzenberg-Bar-Yoseph et al. 2004, Kawauchi et al. 2008).
TP53 negatively regulates several key points in PI3K/AKT signaling and downstream mTOR signaling, decreasing the rate of protein synthesis and, hence, cellular growth. TP53 directly stimulates transcription of the tumor suppressor PTEN, which acts to inhibit PI3K-mediated activation of AKT (Stambolic et al. 2001). TP53 stimulates transcription of sestrin genes, SESN1, SESN2, and SESN3 (Velasco-Miguel et al. 1999, Budanov et al. 2002, Brynczka et al. 2007). One of sestrin functions may be to reduce and reactivate overoxidized peroxiredoxin PRDX1, thereby reducing ROS levels (Budanov et al. 2004, Papadia et al. 2008, Essler et al. 2009). Another function of sestrins is to bind the activated AMPK complex and protect it from AKT-mediated inactivation. By enhancing AMPK activity, sestrins negatively regulate mTOR signaling (Budanov and Karin 2008, Cam et al. 2014). The expression of DDIT4 (REDD1), another negative regulator of mTOR signaling, is directly stimulated by TP63 and TP53. DDIT4 prevents AKT-mediated inactivation of TSC1:TSC2 complex, thus inhibiting mTOR cascade (Cam et al. 2014, Ellisen et al. 2002, DeYoung et al. 2008). TP53 may also be involved, directly or indirectly, in regulation of expression of other participants of PI3K/AKT/mTOR signaling, such as PIK3CA (Singh et al. 2002), TSC2 and AMPKB (Feng et al. 2007).
TP53 regulates mitochondrial metabolism through several routes. TP53 stimulates transcription of SCO2 gene, which encodes a mitochondrial cytochrome c oxidase assembly protein (Matoba et al. 2006). TP53 stimulates transcription of RRM2B gene, which encodes a subunit of the ribonucleotide reductase complex, responsible for the conversion of ribonucleotides to deoxyribonucleotides and essential for the maintenance of mitochondrial DNA content in the cell (Tanaka et al. 2000, Bourdon et al. 2007, Kulawiec et al. 2009). TP53 also transactivates mitochondrial transcription factor A (TFAM), a nuclear-encoded gene important for mitochondrial DNA (mtDNA) transcription and maintenance (Park et al. 2009). Finally, TP53 stimulates transcription of the mitochondrial glutaminase GLS2, leading to increased mitochondrial respiration rate and reduced ROS levels (Hu et al. 2010).
The great majority of tumor cells generate energy through aerobic glycolysis, rather than the much more efficient aerobic mitochondrial respiration, and this metabolic change is known as the Warburg effect (Warburg 1956). Since the majority of tumor cells have impaired TP53 function, and TP53 regulates a number of genes involved in glycolysis and mitochondrial respiration, it is likely that TP53 inactivation plays an important role in the metabolic derangement of cancer cells such as the Warburg effect and the concomitant increased tumorigenicity (reviewed by Feng and Levine 2010). On the other hand, some mutations of TP53 in Li-Fraumeni syndrome may result in the retention of its wild-type metabolic activities while losing cell cycle and apoptosis functions (Wang et al. 2013). Consistent with such human data, some mutations of p53, unlike p53 null state, retain the ability to regulate energy metabolism while being inactive in regulating its classic gene targets involved in cell cycle, apoptosis and senescence. Retention of metabolic and antioxidant functions of p53 protects p53 mutant mice from early onset tumorigenesis (Li et al. 2012)
R-HSA-5689880 Ub-specific processing proteases. Ub-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved motifs with N- or C-terminal extensions and insertions occurring between the conserved motifs (Ye et al. 2009). Two highly conserved regions comprise the catalytic triad, the Cys-box (Cys) and His-box (His and Asp/Asn) (Nijman et al. 2005, Ye et al. 2009, Reyes-Turcu & Wilkinson 2009). They recognize their substrates by interactions of the variable regions with the substrate protein directly, or via scaffolds or adapters in multiprotein complexes R-HSA-5689896 Ovarian tumor domain proteases. Humans have 16 Overian tumour domain (OTU) family DUBs that can be evolutionally divided into three classes, the OTUs, the Otubains (OTUBs), and the A20-like OTUs (Komander et al. 2009). OTU family DUBs can be highly selective in the type of ubiquitin crosslinks they cleave. OTUB1 is specific for K48-linked chains, whereas OTUB2 can cleave K11, K63 and K48-linked poly-Ub (Wang et al. 2009, Edelmann et al. 2009, Mevissen et al. 2013). A20 prefers K48-linked chains, Cezanne is specific for K11-linked chains, and TRABID acts on both K29, K33 and K63-linked poly-Ub (Licchesi et al. 2011, Komander & Barford 2008, Bremm et al. 2010, Mevissen et al. 2013). The active site of the OTU domain contains an unusual loop not seen in other thiol-DUBs and can lack an obvious catalytic Asp/Asn (Komander & Barford 2009, Messick et al. 2008, Lin et al. 2008). A20 and OTUB1 have an unusual mode of activity, binding directly to E2 enzymes (Nakada et al. 2010, Wertz et al. 2004) R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks. Activated ATM phosphorylates a number of proteins involved in the DNA damage checkpoint and DNA repair (Thompson and Schild 2002, Ciccia and Elledge 2010), thereby triggering and coordinating accumulation of DNA DSB repair proteins in nuclear foci known as ionizing radiation-induced foci (IRIF). While IRIFs include chromatin regions kilobases away from the actual DSB site, this Reactome pathway represents simplified foci and events that happen proximal to the DNA DSB ends. In general, proteins localizing to the nuclear foci in response to ATM signaling are cooperatively retained at the DNA DSB site, forming a positive feedback loop and amplifying DNA damage response (Soutoglou and Misteli 2008).Activated ATM phosphorylates the NBN (NBS1) subunit of the MRN complex (MRE11A:RAD50:NBN) (Gatei et al. 2000), as well as the nucleosome histone H2AFX (H2AX) on serine residue S139, producing gamma-H2AFX (gamma-H2AX) containing nucleosomes (Rogakou et al. 1998, Burma et al. 2001). H2AFX is phosphorylated on tyrosine 142 (Y142) under basal conditions (Xiao et al. 2009). After ATM-mediated phosphorylation of H2AFX on S139, tyrosine Y142 has to be dephosphorylated by EYA family phosphatases in order for the DNA repair to proceed and to avoid apoptosis induced by DNA DSBs (Cook et al. 2009). Gamma-H2AFX recruits MDC1 to DNA DSBs (Stucki et al. 2005). After ATM phosphorylates MDC1 (Liu et al. 2012), the MRN complex, gamma-H2AFX nucleosomes, and MDC1 serve as a core of the nuclear focus and a platform for the recruitment of other proteins involved in DNA damage signaling and repair (Lukas et al. 2004, Soutoglou and Misteli 2008).
RNF8 ubiquitin ligase binds phosphorylated MDC1 (Kolas et al. 2007) and, in cooperation with HERC2 and RNF168 (Bekker-Jensen et al. 2010, Campbell et al. 2012), ubiquitinates H2AFX (Mailand et al. 2007, Huen et al. 2007, Stewart et al. 2009, Doil et al. 2009) and histone demethylases KDM4A and KDM4B (Mallette et al. 2012).
Ubiquitinated gamma-H2AFX recruits UIMC1 (RAP80), promoting the assembly of the BRCA1-A complex at DNA DSBs. The BRCA1-A complex consists of RAP80, FAM175A (Abraxas), BRCA1:BARD1 heterodimer, BRCC3 (BRCC36), BRE (BRCC45) and BABAM1 (MERIT40, NBA1) (Wang et al. 2007, Wang and Elledge 2007)
Ubiquitin mediated degradation of KDM4A and KDM4B allows TP53BP1 (53BP1) to associate with histone H4 dimethylated on lysine K21 (H4K20Me2 mark) by WHSC1 at DNA DSB sites (Pei et al. 2011).
Once recruited to DNA DSBs, both BRCA1:BARD1 heterodimers and TP53BP1 are phosphorylated by ATM (Cortez et al. 1999, Gatei et al. 2000, Kim et al. 2006, Jowsey et al. 2007), which triggers recruitment and activation of CHEK2 (Chk2, Cds1) (Wang et al. 2002, Wilson and Stern 2008, Melchionna et al. 2000).
Depending on the cell cycle stage, BRCA1 and TP53BP1 competitively promote either homology directed repair (HDR) or nonhomologous end joining (NHEJ) of DNA DSBs. HDR through homologous recombination repair (HRR) or single strand annealing (SSA) is promoted by BRCA1 in association with RBBP8 (CtIP), while NHEJ is promoted by TP53BP1 in association with RIF1 (Escribano-Diaz et al. 2013)
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling. Interleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand in response to Interleukin-2 (IL2), they can differentiate as Type 1 (Th1) or Type 2 (Th2) T helper cells. The outcome is influenced by IL4. Th2 cells secrete IL4, which both stimulates Th2 in an autocrine fashion and acts as a potent B cell growth factor to promote humoral immunity (Nelms et al. 1999). Interleukin-13 (IL13) is an immunoregulatory cytokine secreted predominantly by activated Th2 cells. It is a key mediator in the pathogenesis of allergic inflammation. IL13 shares many functional properties with IL4, stemming from the fact that they share a common receptor subunit. IL13 receptors are expressed on human B cells, basophils, eosinophils, mast cells, endothelial cells, fibroblasts, monocytes, macrophages, respiratory epithelial cells, and smooth muscle cells, but unlike IL4, not T cells. Thus IL13 does not appear to be important in the initial differentiation of CD4 T cells into Th2 cells, rather it is important in the effector phase of allergic inflammation (Hershey et al. 2003).\n\nIL4 and IL13 induce “alternative activation” of macrophages, inducing an anti-inflammatory phenotype by signaling through IL4R alpha in a STAT6 dependent manner. This signaling plays an important role in the Th2 response, mediating anti-parasitic effects and aiding wound healing (Gordon & Martinez 2010, Loke et al. 2002)\n\nThere are two types of IL4 receptor complex (Andrews et al. 2006). Type I IL4R (IL4R1) is predominantly expressed on the surface of hematopoietic cells and consists of IL4R and IL2RG, the common gamma chain. Type II IL4R (IL4R2) is predominantly expressed on the surface of nonhematopoietic cells, it consists of IL4R and IL13RA1 and is also the type II receptor for IL13. (Obiri et al. 1995, Aman et al. 1996, Hilton et al. 1996, Miloux et al. 1997, Zhang et al. 1997). The second receptor for IL13 consists of IL4R and Interleukin-13 receptor alpha 2 (IL13RA2), sometimes called Interleukin-13 binding protein (IL13BP). It has a high affinity receptor for IL13 (Kd = 250 pmol/L) but is not sufficient to render cells responsive to IL13, even in the presence of IL4R (Donaldson et al. 1998). It is reported to exist in soluble form (Zhang et al. 1997) and when overexpressed reduces JAK-STAT signaling (Kawakami et al. 2001). It's function may be to prevent IL13 signalling via the functional IL4R:IL13RA1 receptor. IL13RA2 is overexpressed and enhances cell invasion in some human cancers (Joshi & Puri 2012).The first step in the formation of IL4R1 (IL4:IL4R:IL2RB) is the binding of IL4 with IL4R (Hoffman et al. 1995, Shen et al. 1996, Hage et al. 1999). This is also the first step in formation of IL4R2 (IL4:IL4R:IL13RA1). After the initial binding of IL4 and IL4R, IL2RB binds (LaPorte et al. 2008), to form IL4R1. Alternatively, IL13RA1 binds, forming IL4R2. In contrast, the type II IL13 complex (IL13R2) forms with IL13 first binding to IL13RA1 followed by recruitment of IL4R (Wang et al. 2009).Crystal structures of the IL4:IL4R:IL2RG, IL4:IL4R:IL13RA1 and IL13:IL4R:IL13RA1 complexes have been determined (LaPorte et al. 2008). Consistent with these structures, in monocytes IL4R is tyrosine phosphorylated in response to both IL4 and IL13 (Roy et al. 2002, Gordon & Martinez 2010) while IL13RA1 phosphorylation is induced only by IL13 (Roy et al. 2002, LaPorte et al. 2008) and IL2RG phosphorylation is induced only by IL4 (Roy et al. 2002).Both IL4 receptor complexes signal through Jak/STAT cascades. IL4R is constitutively-associated with JAK2 (Roy et al. 2002) and associates with JAK1 following binding of IL4 (Yin et al. 1994) or IL13 (Roy et al. 2002). IL2RG constitutively associates with JAK3 (Boussiotis et al. 1994, Russell et al. 1994). IL13RA1 constitutively associates with TYK2 (Umeshita-Suyama et al. 2000, Roy et al. 2002, LaPorte et al. 2008, Bhattacharjee et al. 2013). IL4 binding to IL4R1 leads to phosphorylation of JAK1 (but not JAK2) and STAT6 activation (Takeda et al. 1994, Ratthe et al. 2007, Bhattacharjee et al. 2013). IL13 binding increases activating tyrosine-99 phosphorylation of IL13RA1 but not that of IL2RG. IL4 binding to IL2RG leads to its tyrosine phosphorylation (Roy et al. 2002). IL13 binding to IL4R2 leads to TYK2 and JAK2 (but not JAK1) phosphorylation (Roy & Cathcart 1998, Roy et al. 2002).Phosphorylated TYK2 binds and phosphorylates STAT6 and possibly STAT1 (Bhattacharjee et al. 2013). A second mechanism of signal transduction activated by IL4 and IL13 leads to the insulin receptor substrate (IRS) family (Kelly-Welch et al. 2003). IL4R1 associates with insulin receptor substrate 2 and activates the PI3K/Akt and Ras/MEK/Erk pathways involved in cell proliferation, survival and translational control. IL4R2 does not associate with insulin receptor substrate 2 and consequently the PI3K/Akt and Ras/MEK/Erk pathways are not activated (Busch-Dienstfertig & González-Rodríguez 2013) R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes. Several DNA repair genes contain p53 response elements and their transcription is positively regulated by TP53 (p53). TP53-mediated regulation probably ensures increased protein level of DNA repair genes under genotoxic stress.TP53 directly stimulates transcription of several genes involved in DNA mismatch repair, including MSH2 (Scherer et al. 2000, Warnick et al. 2001), PMS2 and MLH1 (Chen and Sadowski 2005). TP53 also directly stimulates transcription of DDB2, involved in nucleotide excision repair (Tan and Chu 2002), and FANCC, involved in the Fanconi anemia pathway that repairs DNA interstrand crosslinks (Liebetrau et al. 1997). Other p53 targets that can influence DNA repair functions are RRM2B (Kuo et al. 2012), XPC (Fitch et al. 2003), GADD45A (Amundson et al. 2002), CDKN1A (Cazzalini et al. 2010) and PCNA (Xu and Morris 1999). Interestingly, the responsiveness of some of these DNA repair genes to p53 activation has been shown in human cells but not for orthologous mouse genes (Jegga et al. 2008, Tan and Chu 2002). Contrary to the positive modulation of nucleotide excision repair (NER) and mismatch repair (MMR), p53 can negatively modulate base excision repair (BER), by down-regulating the endonuclease APEX1 (APE1), acting in concert with SP1 (Poletto et al. 2016).
Expression of several DNA repair genes is under indirect TP53 control, through TP53-mediated stimulation of cyclin K (CCNK) expression (Mori et al. 2002). CCNK is the activating cyclin for CDK12 and CDK13 (Blazek et al. 2013). The complex of CCNK and CDK12 binds and phosphorylates the C-terminal domain of the RNA polymerase II subunit POLR2A, which is necessary for efficient transcription of long DNA repair genes, including BRCA1, ATR, FANCD2, FANCI, ATM, MDC1, CHEK1 and RAD51D. Genes whose transcription is regulated by the complex of CCNK and CDK12 are mainly involved in the repair of DNA double strand breaks and/or the Fanconi anemia pathway (Blazek et al. 2011, Cheng et al. 2012, Bosken et al. 2014, Bartkowiak and Greenleaf 2015, Ekumi et al. 2015)
R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release. Apoptotic transcriptional targets of TP53 include genes that regulate the permeability of the mitochondrial membrane and/or cytochrome C release, such as BAX, BID, PMAIP1 (NOXA), BBC3 (PUMA) and probably BNIP3L, AIFM2, STEAP3, TRIAP1 and TP53AIP1 (Miyashita and Reed 1995, Oda et al. 2000, Samuels-Lev et al. 2001, Nakano and Vousden 2001, Sax et al. 2002, Passer et al. 2003, Bergamaschi et al. 2004, Li et al. 2004, Fei et al. 2004, Wu et al. 2004, Park and Nakamura 2005, Patel et al. 2008, Wang et al. 2012, Wilson et al. 2013), thus promoting the activation of the apoptotic pathway.Transcriptional activation of TP53AIP1 requires phosphorylation of TP53 at serine residue S46 (Oda et al. 2000, Taira et al. 2007). Phosphorylation of TP53 at S46 is regulated by another TP53 pro-apoptotic target, TP53INP1 (Okamura et al. 2001, Tomasini et al. 2003)
R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain. The exact mechanisms of action of several other pro-apoptotic TP53 (p53) targets, such as TP53I3 (PIG3), RABGGTA, BCL2L14, BCL6, NDRG1 and PERP, remain uncertain (Attardi et al. 2000, Guo et al. 2001, Samuels-Lev et al. 2001, Contente et al. 2002, Ihrie et al. 2003, Bergamaschi et al. 2004, Stein et al. 2004, Phan and Dalla-Favera 2004, Jen and Cheung 2005, Margalit et al. 2006, Zhang et al. 2007, Saito et al. 2009, Davies et al. 2009, Giam et al. 2012) R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases. TP53 (p53) transcriptionally regulates cytosolic caspase activators, such as APAF1, PIDD1, and NLRC4, and caspases themselves, such as CASP1, CASP6 and CASP10. These caspases and their activators are involved either in the intrinsic apoptosis pathway or in the extrinsic apoptosis pathway triggerred by death receptors or the inflammation-related cell death pyroptosis (Lin et al. 2000, Robles et al. 2001, Gupta et al. 2001, MacLachlan and El-Deiry 2002, Rikhof et al. 2003, Sadasivam et al. 2005, Brough and Rothwell 2007) R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands. Pro-apoptotic transcriptional targets of TP53 are TRAIL death receptors TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2), as well as the FASL/CD95L death receptor FAS (CD95). TRAIL receptors and FAS induce pro-apoptotic signaling in response to external stimuli via extrinsic apoptosis pathway (Wu et al. 1997, Takimoto et al. 2000, Guan et al. 2001, Liu et al. 2004, Ruiz de Almodovar et al. 2004, Liu et al. 2005, Schilling et al. 2009, Wilson et al. 2013). IGFBP3 is a transcriptional target of TP53 that may serve as a ligand for a novel death receptor TMEM219 (Buckbinder et al. 1995, Ingermann et al. 2010) R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest. TP53 contributes to the establishment of G2 arrest by inducing transcription of GADD45A and SFN, and by inhibiting transcription of CDC25C. TP53 induces GADD45A transcription in cooperation with chromatin modifying enzymes EP300, PRMT1 and CARM1 (An et al. 2004). GADD45A binds Aurora kinase A (AURKA), inhibiting its catalytic activity and preventing AURKA-mediated G2/M transition (Shao et al. 2006, Sanchez et al. 2010). GADD45A also forms a complex with PCNA. PCNA is involved in both normal and repair DNA synthesis. The effect of GADD45 interaction with PCNA, if any, on S phase progression, G2 arrest and DNA repair is not known (Smith et al. 1994, Hall et al. 1995, Sanchez et al. 2010, Kim et al. 2013). SFN (14-3-3-sigma) is induced by TP53 (Hermeking et al. 1997) and contributes to G2 arrest by binding to the complex of CDK1 and CCNB1 (cyclin B1) and preventing its translocation to the nucleus. Phosphorylation of a number of nuclear proteins by the complex of CDK1 and CCNB1 is needed for G2/M transition (Chan et al. 1999). While promoting G2 arrest, SFN can simultaneously inhibit apoptosis by binding to BAX and preventing its translocation to mitochondria, a step involved in cytochrome C release (Samuel et al. 2001). TP53 binds the promoter of the CDC25C gene in cooperation with the transcriptional repressor E2F4 and represses CDC25C transcription, thus maintaining G2 arrest (St Clair et al. 2004, Benson et al. 2014). The zinc finger transcription factor ZNF385A (HZF) is a direct transcriptional target of TP53 that can form a complex with TP53 and facilitate TP53-mediated induction of SFN transcription (Das et al. 2007) R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain. BTG2 is induced by TP53, leading to cessation of cellular proliferation (Rouault et al. 1996, Duriez et al. 2002). BTG2 binds to the CCR4-NOT complex and promotes mRNA deadenylation activity of this complex. Interaction between BTG2 and CCR4-NOT is needed for the antiproliferative activity of BTG2, but the underlying mechanism has not been elucidated (Rouault et al. 1998, Mauxion et al. 2008, Horiuchi et al. 2009, Doidge et al. 2012, Ezzeddine et al. 2012). Two polo-like kinases, PLK2 and PLK3, are direct transcriptional targets of TP53. TP53-mediated induction of PLK2 may be important for prevention of mitotic catastrophe after spindle damage (Burns et al. 2003). PLK2 is involved in the regulation of centrosome duplication through phosphorylation of centrosome-related proteins CENPJ (Chang et al. 2010) and NPM1 (Krause and Hoffmann 2010). PLK2 is frequently transcriptionally silenced through promoter methylation in B-cell malignancies (Syed et al. 2006). Induction of PLK3 transcription by TP53 (Jen and Cheung 2005) may be important for coordination of M phase events through PLK3-mediated nuclear accumulation of CDC25C (Bahassi et al. 2004). RGCC is induced by TP53 and implicated in cell cycle regulation, possibly through its association with PLK1 (Saigusa et al. 2007). PLAGL1 (ZAC1) is a zinc finger protein directly transcriptionally induced by TP53 (Rozenfeld-Granot et al. 2002). PLAGL1 expression is frequently lost in cancer (Varrault et al. 1998) and PLAGL1 has been implicated in both cell cycle arrest and apoptosis (Spengler et al. 1997), but its mechanism of action remains unknown R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest. The most prominent TP53 target involved in G1 arrest is the inhibitor of cyclin-dependent kinases CDKN1A (p21). CDKN1A is one of the earliest genes induced by TP53 (El-Deiry et al. 1993). CDKN1A binds and inactivates CDK2 in complex with cyclin A (CCNA) or E (CCNE), thus preventing G1/S transition (Harper et al. 1993). Considering its impact on the cell cycle outcome, CDKN1A expression levels are tightly regulated. For instance, under prolonged stress, TP53 can induce the transcription of an RNA binding protein PCBP4, which can bind and destabilize CDKN1A mRNA, thus alleviating G1 arrest and directing the affected cell towards G2 arrest and, possibly, apoptosis (Zhu and Chen 2000, Scoumanne et al. 2011). Expression of E2F7 is directly induced by TP53. E2F7 contributes to G1 cell cycle arrest by repressing transcription of E2F1, a transcription factor that promotes expression of many genes needed for G1/S transition (Aksoy et al. 2012, Carvajal et al. 2012). ARID3A is a direct transcriptional target of TP53 (Ma et al. 2003) that may promote G1 arrest by cooperating with TP53 in induction of CDKN1A transcription (Lestari et al. 2012). However, ARID3A may also promote G1/S transition by stimulating transcriptional activity of E2F1 (Suzuki et al. 1998, Peeper et al. 2002).TP53 has co-factors that are key determinants of transcriptional selectivity within the p53 network. For instance, the zinc finger transcription factor ZNF385A (HZF) is a direct transcriptional target of TP53 that can form a complex with TP53 and facilitate TP53-mediated induction of CDKN1A, strongly favouring cell cycle arrest over apoptosis (Das et al. 2007)
R-HSA-6804754 Regulation of TP53 Expression. Transcription of the TP53 (p53) gene is negatively regulated by the TP53 transcriptional target PRDM1 (BLIMP1), which binds to the promoter region of TP53 and probably induces repressive methylation (Yan et al. 2007).TP53 functions as a homotetramer (Jeffrey et al. 1995, Waterman et al. 1995)
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation. Phosphorylation of TP53 (p53) at the N-terminal serine residues S15 and S20 plays a critical role in protein stabilization as phosphorylation at these sites interferes with binding of the ubiquitin ligase MDM2 to TP53. Several different kinases can phosphorylate TP53 at S15 and S20. In response to double strand DNA breaks, S15 is phosphorylated by ATM (Banin et al. 1998, Canman et al. 1998, Khanna et al. 1998), and S20 by CHEK2 (Chehab et al. 1999, Chehab et al. 2000, Hirao et al. 2000). DNA damage or other types of genotoxic stress, such as stalled replication forks, can trigger ATR-mediated phosphorylation of TP53 at S15 (Lakin et al. 1999, Tibbetts et al. 1999) and CHEK1-mediated phosphorylation of TP53 at S20 (Shieh et al. 2000). In response to various types of cell stress, NUAK1 (Hou et al. 2011), CDK5 (Zhang et al. 2002, Lee et al. 2007, Lee et al. 2008), AMPK (Jones et al. 2005) and TP53RK (Abe et al. 2001, Facchin et al. 2003) can phosphorylate TP53 at S15, while PLK3 (Xie, Wang et al. 2001, Xie, Wu et al. 2001) can phosphorylate TP53 at S20.Phosphorylation of TP53 at serine residue S46 promotes transcription of TP53-regulated apoptotic genes rather than cell cycle arrest genes. Several kinases can phosphorylate S46 of TP53, including ATM-activated DYRK2, which, like TP53, is targeted for degradation by MDM2 (Taira et al. 2007, Taira et al. 2010). TP53 is also phosphorylated at S46 by HIPK2 in the presence of the TP53 transcriptional target TP53INP1 (D'Orazi et al. 2002, Hofmann et al. 2002, Tomasini et al. 2003). CDK5, in addition to phosphorylating TP53 at S15, also phosphorylates it at S33 and S46, which promotes neuronal cell death (Lee et al. 2007).
MAPKAPK5 (PRAK) phosphorylates TP53 at serine residue S37, promoting cell cycle arrest and cellular senescence in response to oncogenic RAS signaling (Sun et al. 2007).
NUAK1 phosphorylates TP53 at S15 and S392, and phosphorylation at S392 may contribute to TP53-mediated transcriptional activation of cell cycle arrest genes (Hou et al. 2011). S392 of TP53 is also phosphorylated by the complex of casein kinase II (CK2) bound to the FACT complex, enhancing transcriptional activity of TP53 in response to UV irradiation (Keller et al. 2001, Keller and Lu 2002).
The activity of TP53 is inhibited by phosphorylation at serine residue S315, which enhances MDM2 binding and degradation of TP53. S315 of TP53 is phosphorylated by Aurora kinase A (AURKA) (Katayama et al. 2004) and CDK2 (Luciani et al. 2000). Interaction with MDM2 and the consequent TP53 degradation is also increased by phosphorylation of TP53 threonine residue T55 by the transcription initiation factor complex TFIID (Li et al. 2004).
Aurora kinase B (AURKB) has been shown to phosphorylate TP53 at serine residue S269 and threonine residue T284, which is possibly facilitated by the binding of the NIR co-repressor. AURKB-mediated phosphorylation was reported to inhibit TP53 transcriptional activity through an unknown mechanism (Wu et al. 2011). A putative direct interaction between TP53 and AURKB has also been described and linked to TP53 phosphorylation and S183, T211 and S215 and TP53 degradation (Gully et al. 2012)
R-HSA-6804757 Regulation of TP53 Degradation. In unstressed cells, TP53 (p53) has a short half-life as it undergoes rapid ubiquitination and proteasome-mediated degradation. The E3 ubiquitin ligase MDM2, which is a transcriptional target of TP53, plays the main role in TP53 protein down-regulation (Wu et al. 1993). MDM2 forms homodimers and homo-oligomers, but also functions as a heterodimer/hetero-oligomer with MDM4 (MDMX) (Sharp et al. 1999, Cheng et al. 2011, Huang et al. 2011, Pant et al. 2011). The heterodimers of MDM2 and MDM4 may be especially important for downregulation of TP53 during embryonic development (Pant et al. 2011).The nuclear localization of MDM2 is positively regulated by AKT- or SGK1- mediated phosphorylation (Mayo and Donner 2001, Zhou et al. 2001, Amato et al. 2009, Lyo et al. 2010). Phosphorylation of MDM2 by CDK1 or CDK2 decreases affinity of MDM2 for TP53 (Zhang and Prives 2001). ATM and CHEK2 kinases, activated by double strand DNA breaks, phosphorylate TP53, reducing its affinity for MDM2 (Banin et al. 1998, Canman et al. 1998, Khanna et al. 1998, Chehab et al. 1999, Chehab et al. 2000). At the same time, ATM phosphorylates MDM2, preventing MDM2 dimerization (Cheng et al. 2009, Cheng et al. 2011). Both ATM and CHEK2 phosphorylate MDM4, triggering MDM2-mediated ubiquitination of MDM4 (Chen et al. 2005, Pereg et al. 2005). Cyclin G1 (CCNG1), transcriptionally induced by TP53, targets the PP2A phosphatase complex to MDM2, resulting in dephosphorylation of MDM2 at specific sites, which can have either a positive or a negative impact on MDM2 function (Okamoto et al. 2002).
In contrast to MDM2, E3 ubiquitin ligases RNF34 (CARP1) and RFFL (CARP2) can ubiquitinate phosphorylated TP53 (Yang et al. 2007).
In addition to ubiquitinating MDM4 (Pereg et al. 2005), MDM2 can also undergo auto-ubiquitination (Fang et al. 2000). MDM2 and MDM4 can be deubiquitinated by the ubiquitin protease USP2 (Stevenson et al. 2007, Allende-Vega et al. 2010). The ubiquitin protease USP7 can deubiquitinate TP53, but in the presence of DAXX deubiquitinates MDM2 (Li et al. 2002, Sheng et al. 2006, Tang et al. 2006).
The tumor suppressor p14-ARF, expressed from the CDKN2A gene in response to oncogenic or oxidative stress, forms a tripartite complex with MDM2 and TP53, sequesters MDM2 from TP53, and thus prevents TP53 degradation (Zhang et al. 1998, Parisi et al. 2002, Voncken et al. 2005).
For review of this topic, please refer to Kruse and Gu 2009
R-HSA-6804758 Regulation of TP53 Activity through Acetylation. Transcriptional activity of TP53 is positively regulated by acetylation of several of its lysine residues. BRD7 binds TP53 and promotes acetylation of TP53 lysine residue K382 by acetyltransferase EP300 (p300). Acetylation of K382 enhances TP53 binding to target promoters, including CDKN1A (p21), MDM2, SERPINE1, TIGAR, TNFRSF10C and NDRG1 (Bensaad et al. 2010, Burrows et al. 2010. Drost et al. 2010). The histone acetyltransferase KAT6A, in the presence of PML, also acetylates TP53 at K382, and, in addition, acetylates K120 of TP53. KAT6A-mediated acetylation increases transcriptional activation of CDKN1A by TP53 (Rokudai et al. 2013). Acetylation of K382 can be reversed by the action of the NuRD complex, containing the TP53-binding MTA2 subunit, resulting in inhibition of TP53 transcriptional activity (Luo et al. 2000). Acetylation of lysine K120 in the DNA binding domain of TP53 by the MYST family acetyltransferases KAT8 (hMOF) and KAT5 (TIP60) can modulate the decision between cell cycle arrest and apoptosis (Sykes et al. 2006, Tang et al. 2006). Studies with acetylation-defective knock-in mutant mice indicate that lysine acetylation in the p53 DNA binding domain acts in part by uncoupling transactivation and transrepression of gene targets, while retaining ability to modulate energy metabolism and production of reactive oxygen species (ROS) and influencing ferroptosis (Li et al. 2012, Jiang et al. 2015) R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors. Association of TP53 (p53) with various transcriptional co-factors can promote, inhibit or provide specificity towards either transcription of cell cycle arrest genes or transcription of cell death genes. Binding of the zinc finger protein ZNF385A (HZF), which is a transcriptional target of TP53, stimulates transcription of cell cycle arrest genes, such as CDKN1A (Das et al. 2007). Binding of POU4F1 (BRN3A) to TP53 also stimulates transcription of cell cycle arrest genes while inhibiting transcription of pro-apoptotic genes (Budhram-Mahadeo et al. 1999, Hudson et al. 2005).Binding of ASPP family proteins PPP1R13B (ASPP1) or TP53BP2 (ASPP2) to TP53 stimulates transcription of pro-apoptotic TP53 targets (Samuels-Lev et al. 2001, Bergamaschi et al. 2004). Binding of the ASPP family member PPP1R13L (iASSP) inhibits TP53-mediated activation of pro-apoptotic genes probably by interfering with binding of stimulatory ASPPs to TP53 (Bergamaschi et al. 2003). Transcription of pro-apoptotic genes is also stimulated by binding of TP53 to POU4F2 (BRN3B) (Budrham-Mahadeo et al. 2006, Budhram-Mahadeo et al. 2014) or to hCAS/CSE1L (Tanaka et al. 2007).
Binding of co-factors to TP53 can also affect protein stability. For example, PHF20 binds to TP53 dimethylated on lysine residues K370 and K382 by unidentified protein lysine methyltransferase(s) and interferes with MDM2 binding, resulting in prolonged TP53 half-life (Cui et al. 2012). Long noncoding RNAs can contribute to p53-dependent transcriptional responses (Huarte et al. 2010). For a general review on this topic, see Espinosa 2008, Beckerman and Prives 2010, Murray-Zmijewski et al. 2008, An et al. 2004 and Barsotti and Prives 2010
R-HSA-6804760 Regulation of TP53 Activity through Methylation. TP53 (p53) undergoes methylation on several lysine and arginine residues, which modulates its transcriptional activity.PRMT5, recruited to TP53 as part of the ATM-activated complex that includes TTC5, JMY and EP300 (p300), methylates TP53 arginine residues R333, R335 and R337. PRMT5-mediated methylation promotes TP53-stimulated expression of cell cycle arrest genes (Shikama et al. 1999, Demonacos et al. 2001, Demonacos et al. 2004, Adams et al. 2008, Adams et al. 2012). SETD9 (SET9) methylates TP53 at lysine residue K372, resulting in increased stability and activity of TP53 (Chuikov et al. 2004, Couture et al. 2006, Bai et al. 2011).
TP53 transcriptional activity is repressed by SMYD2-mediated methylation of TP53 at lysine residue K370 (Huang et al. 2006). Dimethylation of TP53 at lysine residue K373 by the complex of methyltransferases EHMT1 and EHMT2 also represses TP53-mediated transcription (Huang et al. 2010). The chromatin compaction factor L3MBTL1 binds TP53 monomethylated at lysine K382 by SETD8 (SET8) and, probably through changing local chromatin architecture, represses transcription of TP53 targets (West et al. 2010). The histone lysine-specific demethylase LSD1 interacts with TP53 and represses p53-mediated transcriptional activation (Huang et al. 2007). PRMT1 and CARM1 can also modulate p53 functions in a cooperative manner (An et al. 2004)
R-HSA-6811555 PI5P Regulates TP53 Acetylation. Under conditions of cellular stress, nuclear levels of phosphatidylinositol-5-phosphate (PI5P) increase and, through interaction with ING2, result in nuclear retention/accumulation of ING2. ING2 binds TP53 (p53) and recruits histone acetyltransferase EP300 (p300) to TP53, leading to TP53 acetylation. Increased nuclear PI5P levels positively regulate TP53 acetylation (Ciruela et al. 2000, Gozani et al. 2003, Jones et al. 2006, Zou et al. 2007, Bultsma et al. 2010) R-HSA-69473 G2/M DNA damage checkpoint. Throughout the cell cycle, the genome is constantly monitored for damage, resulting either from errors of replication, by-products of metabolism or through extrinsic sources such as ultra-violet or ionizing radiation. The different DNA damage checkpoints act to inhibit or maintain the inhibition of the relevant CDK that will control the next cell cycle transition. The G2 DNA damage checkpoint prevents mitotic entry solely through T14Y15 phosphorylation of Cdc2 (Cdk1). Failure of the G2 DNA damage checkpoint leads to catastrophic attempts to segregate unrepaired chromosomes R-HSA-69481 G2/M Checkpoints. G2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they follow normal transition to the M phase. However, if any of these checkpoints fail, mitotic entry is prevented by specific G2/M checkpoint events.The G2/M checkpoints can fail due to the presence of unreplicated DNA or damaged DNA. In such instances, the cyclin-dependent kinase, Cdc2(Cdk1), is maintained in its inactive, phosphorylated state, and mitotic entry is prevented. Events that ensure that origins of DNA replication fire once and only once per cell cycle are also an example of a G2/M checkpoint.
In the event of high levels of DNA damage, the cells may also be directed to undergo apopotosis (not covered)
R-HSA-69541 Stabilization of p53. Later studies pin-pointed that a single serine (Ser-15) was phosphorylated by ATM and phosphorylation of Ser-15 was rapidly-induced in IR-treated cells and this response was ATM-dependent (Canman et al, 1998; Banin et al, 1998 and Khanna et al, 1998). ATM also regulates the phosphorylation of p53 at other sites, especially Ser-20, by activating other serine/threonine kinases in response to IR (Chehab et al, 2000; Shieh et al, 2000; Hirao et al 2000). Phosphorylation of p53 at Ser-20 interferes with p53-MDM2 interaction. MDM2 is transcriptionally activated by p53 and is a negative regulator of p53 that targets it for degradation (Haupt et al, 1997; Kubbutat et al, 1997). In addition modification of MDM2 by ATM also affects p53 stabilization (Maya et al, 2001) R-HSA-69895 Transcriptional activation of cell cycle inhibitor p21. Both p53-independent and p53-dependent mechanisms of induction of p21 mRNA have been demonstrated. p21 is transcriptionally activated by p53 after DNA damage (el-Deiry et al., 1993) R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint. GTSE1 (B99) was identified as a microtubule-associated protein product of the mouse B99 gene, which exhibits both a cell cycle regulated expression, with highest levels in G2, and DNA damage triggered expression under direct control of TP53 (p53) (Utrera et al. 1998, Collavin et al. 2000). Human GTSE1, similar to the mouse counterpart, binds to microtubules, shows cell cycle regulated expression with a peak in G2 and plays a role in G2 checkpoint recovery after DNA damage but is not transcriptionally regulated by TP53 (Monte et al. 2003, Monte et al. 2004, Scolz et al. 2012).In G1 cells, GTSE1 is found at the microtubule lattice, likely due to direct binding to tubulin. An evolutionarily conserved interaction between GTSE1 and MAPRE1 (EB1), a microtubule plus end protein, promotes GTSE1 localization to the growing tip of the microtubules, which contributes to cell migration and is likely involved in cancer cell invasiveness. Highly invasive breast cancer cell lines exhibit high GTSE1 levels in G1, while GTSE1 levels in G1 are normally low. At the beginning of mitotic prometaphase, GTSE1 is phosphorylated by mitotic kinase(s), possibly CDK1, in proximity to the MAPRE1-binding region, causing GTSE1 dissociation from the plus end microtubule ends (Scolz et al. 2012).
During G2 checkpoint recovery (cell cycle re-entry after DNA damage induced G2 arrest), GTSE1 relocates to the nucleus where it binds TP53 and, in an MDM2-dependent manner, promotes TP53 cytoplasmic translocation and proteasome mediated degradation (Monte et al. 2003, Monte et al. 2004). Relocation of GTSE1 to the nucleus in G2 phase depends on PLK1-mediated phosphorylation of GTSE1 (Liu et al. 2010).
GTSE1-facilitated down-regulation of TP53 in G2 allows cells to avoid TP53 mediated apoptosis upon DNA damage and to re-enter cell cycle (Monte et al. 2003). While TP53 down-regulation mediated by GTSE1 in G2 correlates with decreased expression of TP53 target genes involved in apoptosis and cell cycle arrest, GTSE1 can also increase the half-life of the TP53 target p21 (CDKN1A). GTSE1-mediated stabilization of CDKN1A involves interaction of GTSE1 with CDKN1A and its chaperone complex, consisting of HSP90 and FKBPL (WISp39), and may be involved in resistance to paclitaxel treatment (Bublik et al. 2010)
R-HSA-8941855 RUNX3 regulates CDKN1A transcription. RUNX3 contributes to the upregulation of the CDKN1A (p21) gene transcription in response to TGF-beta (TGFB1) signaling. RUNX3 binds to SMAD3 and SMAD4, and cooperates with the activated SMAD3:SMAD4 complex in transactivation of CDKN1A. Runx3 knockout mice exhibit decreased sensitivity to TGF-beta and develop gastric epithelial hyperplasia (Chi et al. 2005). In response to TGF-beta signaling, the CBFB:RUNX3 complex binds to the tumor suppressor ZFHX3 (ATBF1) and, through an unknown mechanism, this complex positively regulates the CDKN1A transcription (Mabuchi et al. 2010).In addition, RUNX3 may act as a TP53 co-factor, stimulating TP53-mediated transcription of target genes, including CDKN1A (p21) (Yamada et al. 2010) R-HSA-8943724 Regulation of PTEN gene transcription. Transcription of the PTEN gene is regulated at multiple levels. Epigenetic repression involves the recruitment of Mi-2/NuRD upon SALL4 binding to the PTEN promoter (Yang et al. 2008, Lu et al. 2009) or EVI1-mediated recruitment of the polycomb repressor complex (PRC) to the PTEN promoter (Song et al. 2009, Yoshimi et al. 2011). Transcriptional regulation is also elicited by negative regulators, including NR2E1:ATN1 (atrophin-1) complex, JUN (c-Jun), SNAIL and SLUG (Zhang et al. 2006, Vasudevan et al. 2007, Escriva et al. 2008, Uygur et al. 2015) and positive regulators such as TP53 (p53), MAF1, ATF2, EGR1 or PPARG (Stambolic et al. 2001, Virolle et al. 2001, Patel et al. 2001, Shen et al. 2006, Li et al. 2016) R-HSA-983231 Factors involved in megakaryocyte development and platelet production. Megakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they undergo endoreduplication (polyploidisation) and expansion of cytoplasmic mass to cell sizes larger than 50-100 microns, and ploidy ranges up to 128 N. As MKs mature, the polyploid nucleus becomes horseshoe-shaped, the cytoplasm expands, and platelet organelles and the demarcation membrane system are amplified. Proplatelet projections form which give rise to de novo circulating platelets (Deutsch & Tomer 2006). The processes of megakaryocytopoiesis and platelet production occur within a complex microenvironment where chemokines, cytokines and adhesive interactions play major roles (Avecilla et al. 2004). Megakaryocytopoiesis is regulated at several levels including proliferation, differentiation and platelet release (Kaushansky 2003). Thrombopoietin (TPO/c-Mpl ligand) is the most potent cytokine stimulating proliferation and maturation of MK progenitors (Kaushansky 2005) but many other growth factors are involved. MK development is controlled by the action of multiple transcription factors. Many MK-specific genes are co-regulated by GATA and friend of GATA (FOG), RUNX1 and ETS proteins. Nuclear factor erythroid 2 (NF-E2), which has an MK-erythroid specific 45-kDa subunit, controls terminal MK maturation, proplatelet formation and platelet release (Schulze & Shivdasani 2004). NF-E2 deficient mice have profound thrombocytopenia (Shiraga et al. 1999). MYB (c-myb) functions with EP300 (p300) as a negative regulator of thrombopoiesis (Metcalf et al. 2005). During MK maturation, internal membrane systems, granules and organelles are assembled. Cytoplasmic fragmentation requires changes in the MK cytoskeleton and formation of organelles and channels. Individual organelles migrate from the cell body to the proplatelet ends, with approximately 30 percent of organelles/granules in motion at any given time (Richardson et al. 2005)
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ABCE1 Affinity Capture-MS physical 25659154 , (Europe PMC )NA BioGRID ABL1 Reconstituted Complex physical 10629029 , (Europe PMC )NA BioGRID ABR Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ABRAXAS2 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 25283148 , 26186194 , 28514442 , (Europe PMC )NA BioGRID ACKR3 Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID ACSL4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ACTA2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ACTB Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID ACTBL2 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID ACTL6A Affinity Capture-Western physical 17878219 , (Europe PMC )NA BioGRID ACVR1C Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ADAM28 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ADH5 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID AGBL2 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID AGO1 Affinity Capture-MS, Affinity Capture-Western physical 20308539 , 24778252 , (Europe PMC )NA BioGRID AGO2 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID AGT Two-hybrid physical 22416758 , (Europe PMC )NA BioGRID AIFM2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID AIMP2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, pull down, two hybrid direct interaction, physical, physical association 18695251 , (Europe PMC )0.59 BioGRID, IntAct AIPL1 Affinity Capture-MS, inference by socio-affinity scoring, tandem affinity purification association, physical, physical association 27173435 , (Europe PMC )0.51 BioGRID, IntAct AKAP12 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ALYREF Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID ANG Affinity Capture-Western physical 22266868 , (Europe PMC )NA BioGRID ANK2 Reconstituted Complex, display technology physical, physical association 20195357 , (Europe PMC )0.40 BioGRID, IntAct ANKRD2 Affinity Capture-Western, Reconstituted Complex physical 15136035 , (Europe PMC )NA BioGRID ANXA2 Reconstituted Complex physical 9315650 , (Europe PMC )NA BioGRID ANXA3 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct ANXA7 Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT APEX1 Affinity Capture-Western, Co-purification physical 15824742 , 9119221 , (Europe PMC )NA BioGRID APOH Two-hybrid, two hybrid physical, physical association 18624398 , (Europe PMC )0.37 BioGRID, IntAct APPL1 Two-hybrid, two hybrid array physical, physical association 25814554 , (Europe PMC )0.37 BioGRID, IntAct APTX Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down association, physical 15044383 , (Europe PMC )0.46 BioGRID, IntAct AR Phenotypic Suppression, two hybrid genetic, physical association 11504717 , 19481544 , (Europe PMC )0.37 BioGRID, IntAct, MINT ARHGEF17 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ARID1A Affinity Capture-Western, Reconstituted Complex physical 21900401 , (Europe PMC )NA BioGRID ARID3A Affinity Capture-Western physical 15017387 , (Europe PMC )NA BioGRID ARIH2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, pull down, two hybrid pooling approach association, direct interaction, physical, physical association 16169070 , 22819825 , (Europe PMC )0.69 BioGRID, IntAct, MINT ARL3 Synthetic Growth Defect, Two-hybrid, two hybrid pooling approach genetic, physical, physical association 16169070 , 23284306 , (Europe PMC )0.37 BioGRID, IntAct ARMCX5 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ARPP21 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ASF1A Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID ASH2L Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, physical 19433796 , 23870121 , (Europe PMC )0.64 BioGRID, IntAct ASPM Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID ATF3 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid pooling approach physical, physical association 11792711 , 15933712 , 16169070 , 24554706 , (Europe PMC )0.37 BioGRID, IntAct ATM Biochemical Activity, Co-localization, Phenotypic Enhancement, Protein-peptide, Reconstituted Complex, experimental interaction detection genetic, phosphorylation reaction, physical 10608806 , 10713094 , 10744722 , 10864201 , 11459832 , 14744854 , 15064416 , 15159397 , 15632067 , 15790808 , 17409407 , 19965871 , 21383020 , 23907539 , 24469230 , 25086746 , 27559048 , 9135004 , 9843217 , (Europe PMC )0.31 BioGRID, IntAct, MINT ATP5F1A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ATR Affinity Capture-Western, Biochemical Activity, Protein-peptide, Reconstituted Complex, Synthetic Growth Defect, protein kinase assay genetic, phosphorylation reaction, physical 10435622 , 10608806 , 11459832 , 15159397 , 15775976 , 16293623 , 20798688 , 23284306 , (Europe PMC )0.44 BioGRID, IntAct ATRX Affinity Capture-MS physical 23329831 , (Europe PMC )NA BioGRID ATXN3 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 27851749 , (Europe PMC )NA BioGRID AURKA Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Phenotypic Suppression, Reconstituted Complex, Two-hybrid genetic, physical 12198151 , 14702041 , 23201157 , 26186194 , 28514442 , (Europe PMC )NA BioGRID AURKB Affinity Capture-Western, protein kinase assay phosphorylation reaction, physical 20959462 , 29340707 , (Europe PMC )0.44 BioGRID, IntAct AXIN1 Affinity Capture-Western, Phenotypic Suppression, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation genetic, physical, physical association 21057547 , 23826318 , (Europe PMC )0.52 BioGRID, IntAct BABAM2 Affinity Capture-MS, Affinity Capture-Western, Co-purification physical 14636569 , (Europe PMC )NA BioGRID BACH1 Affinity Capture-Western, Reconstituted Complex physical 19011633 , (Europe PMC )NA BioGRID BAG1 Phenotypic Suppression genetic 9582267 , (Europe PMC )NA BioGRID BAG2 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , 27807478 , (Europe PMC )0.35 BioGRID, IntAct, MINT BAG5 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 25144556 , 27807478 , (Europe PMC )NA BioGRID BAIAP2L1 Affinity Capture-Western, Reconstituted Complex physical 21887275 , (Europe PMC )NA BioGRID BAK1 Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Reconstituted Complex physical 15077116 , 21712378 , 25408501 , 27818144 , (Europe PMC )NA BioGRID BANP Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation association, physical, physical association 19303885 , 20075864 , 22074660 , (Europe PMC )0.50 BioGRID, IntAct, MINT BARD1 Affinity Capture-MS, Affinity Capture-Western, Co-localization, anti bait coimmunoprecipitation physical, physical association 14636569 , 15782130 , 21742769 , 26022179 , (Europe PMC )0.40 BioGRID, IntAct BAX Affinity Capture-Western, Co-localization, Reconstituted Complex, proximity ligation assay physical, physical association 25115399 , 25241761 , (Europe PMC )0.40 BioGRID, IntAct BCL2 Affinity Capture-Western, anti bait coimmunoprecipitation association, physical, physical association 12667443 , 19521340 , 21597459 , 21624955 , (Europe PMC )0.56 BioGRID, IntAct, MINT BCL2L1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence polarization spectroscopy, isothermal titration calorimetry, nuclear magnetic resonance, pull down, surface plasmon resonance, two hybrid association, direct interaction, physical, physical association 12667443 , 14963330 , 16151013 , 20837658 , 21900206 , 24474649 , 24814347 , 25115399 , 26556313 , (Europe PMC )0.37, 0.88 BioGRID, IntAct, MINT BCL2L12 Reconstituted Complex physical 20837658 , (Europe PMC )NA BioGRID BCL2L2 Affinity Capture-Western, Protein-peptide, Reconstituted Complex physical 24491548 , 25115399 , (Europe PMC )NA BioGRID BCL6 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct BCR Co-localization, Two-hybrid, proximity ligation assay, two hybrid pooling approach physical, physical association 16169070 , 25241761 , (Europe PMC )0.57 BioGRID, IntAct BECN1 Affinity Capture-Western physical 28128446 , (Europe PMC )NA BioGRID BHLHE40 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, imaging technique, pull down association, colocalization, physical, physical association 17347673 , 22723347 , (Europe PMC )0.73 BioGRID, IntAct, MINT BIRC6 Affinity Capture-Western physical 25196217 , (Europe PMC )NA BioGRID BLM Affinity Capture-MS, Affinity Capture-Western, Co-localization, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation association, physical 11399766 , 11781842 , 12080066 , 15364958 , 22653443 , 24239288 , (Europe PMC )0.35 BioGRID, IntAct, MINT BMI1 Affinity Capture-Western physical 22907436 , 24039897 , (Europe PMC )NA BioGRID BMP1 Two-hybrid, two hybrid physical, physical association 18624398 , (Europe PMC )0.37 BioGRID, IntAct BRCA1 Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, coimmunoprecipitation, pull down direct interaction, physical, physical association 14636569 , 14710355 , 15571721 , 16677609 , 16969499 , 19509300 , 21742769 , 26140185 , 9482880 , 9582019 , 9926942 , (Europe PMC )0.54 BioGRID, IntAct, MINT BRCA2 Affinity Capture-MS, Affinity Capture-Western, Co-purification, classical fluorescence spectroscopy, isothermal titration calorimetry, nuclear magnetic resonance, pull down direct interaction, physical 14636569 , 20421506 , 9811893 , (Europe PMC )0.65 BioGRID, IntAct BRCC3 Affinity Capture-MS, Affinity Capture-Western, Co-purification physical 14636569 , (Europe PMC )NA BioGRID BRD7 Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy, pull down, two hybrid colocalization, physical, physical association 20228809 , 20660729 , (Europe PMC )0.73 BioGRID, IntAct BRD8 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID BRF1 Affinity Capture-Western physical 8943363 , (Europe PMC )NA BioGRID BRINP1 Affinity Capture-Western physical 25732823 , (Europe PMC )NA BioGRID BTBD2 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.51 BioGRID, IntAct BTRC Affinity Capture-Western, anti tag coimmunoprecipitation physical, physical association 19196987 , 21521785 , (Europe PMC )0.40 BioGRID, IntAct C10orf90 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 24240685 , 26223354 , (Europe PMC )NA BioGRID C12orf49 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID CABLES1 Affinity Capture-Western, coimmunoprecipitation physical, physical association 11706030 , 14637168 , (Europe PMC )0.40 BioGRID, IntAct CABLES2 Affinity Capture-Western physical 14637168 , (Europe PMC )NA BioGRID CAD Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID CALD1 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID CAPG Two-hybrid physical 18307271 , (Europe PMC )NA BioGRID CAPN1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID CAPZB Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID CARM1 Reconstituted Complex physical 15186775 , (Europe PMC )NA BioGRID CASP8 Affinity Capture-Western physical 17290218 , (Europe PMC )NA BioGRID CCAR1 Affinity Capture-Western physical 18382127 , (Europe PMC )NA BioGRID CCDC106 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, fluorescence microscopy, two hybrid pooling approach colocalization, physical, physical association 16169070 , 20159018 , (Europe PMC )0.61 BioGRID, IntAct, MINT CCDC8 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 22084066 , 22653443 , 23443559 , 24711643 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCL18 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct CCNA2 Reconstituted Complex physical 10884347 , (Europe PMC )NA BioGRID CCND1 Affinity Capture-Western physical 27129163 , (Europe PMC )NA BioGRID CCNG1 Affinity Capture-Western, Reconstituted Complex physical 12556559 , 12642871 , (Europe PMC )NA BioGRID CCNH Affinity Capture-Western, Far Western physical 9840937 , (Europe PMC )NA BioGRID CCT2 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT3 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT4 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT5 Affinity Capture-MS, Two-hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach association, physical, physical association 16169070 , 22653443 , 23443559 , 25144556 , (Europe PMC )0.55 BioGRID, IntAct, MINT CCT6A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT7 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT8 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CDC14A Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 10644693 , (Europe PMC )NA BioGRID CDC14B Affinity Capture-Western, Reconstituted Complex physical 10644693 , (Europe PMC )NA BioGRID CDC42 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct CDK1 Affinity Capture-Western, Biochemical Activity physical 10884347 , 11327730 , (Europe PMC )NA BioGRID CDK2 Biochemical Activity, Co-localization, proximity ligation assay physical, physical association 10884347 , 19556892 , 25241761 , (Europe PMC )0.40 BioGRID, IntAct CDK5 Affinity Capture-Western, Reconstituted Complex physical 17591690 , (Europe PMC )NA BioGRID CDK7 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 9315650 , 9372954 , 9840937 , (Europe PMC )NA BioGRID CDK8 Reconstituted Complex physical 10024883 , (Europe PMC )NA BioGRID CDK9 Affinity Capture-Western, Biochemical Activity, Phenotypic Suppression, Reconstituted Complex genetic, physical 10656684 , 16741955 , (Europe PMC )NA BioGRID CDKN1A Affinity Capture-Western, Co-localization, Two-hybrid, imaging technique, proximity ligation assay, two hybrid colocalization, physical, physical association 11896572 , 12897156 , 16616141 , 17371838 , 21900206 , 25241761 , (Europe PMC )0.65 BioGRID, IntAct, MINT CDKN1C Affinity Capture-MS physical 12665691 , (Europe PMC )NA BioGRID CDKN2A Affinity Capture-Western physical 12446718 , 14612427 , 20395212 , 9529249 , 9653180 , 9724636 , (Europe PMC )NA BioGRID CDKN2C Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct CEBPZ Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down physical, physical association 12534345 , (Europe PMC )0.52 BioGRID, IntAct, MINT CELA2B Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID CENPA Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID CEP120 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP128 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP135 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP152 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP55 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID CETP Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID CFLAR Affinity Capture-Western physical 18559494 , 21474069 , (Europe PMC )NA BioGRID CFTR Affinity Capture-MS physical 26618866 , (Europe PMC )NA BioGRID CHD3 Two-hybrid physical 10961991 , 15383276 , (Europe PMC )NA BioGRID CHD8 Affinity Capture-Western physical 19151705 , (Europe PMC )NA BioGRID CHEK1 Affinity Capture-Western, Biochemical Activity, Co-localization, protein kinase assay phosphorylation reaction, physical 10673501 , 11896572 , 12756247 , 15364958 , 16511572 , (Europe PMC )0.44 BioGRID, IntAct, MINT CHEK2 Affinity Capture-Western, Biochemical Activity, experimental interaction detection, protein kinase assay phosphorylation reaction, physical 10673501 , 10710310 , 10724175 , 12810724 , 15862297 , 18833288 , (Europe PMC )0.65 BioGRID, IntAct, MINT CHMP4B Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID CHUK Affinity Capture-Western physical 17434128 , (Europe PMC )NA BioGRID CKAP4 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID CLCA3P Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID CLK3 Affinity Capture-MS, tandem affinity purification association, physical 23602568 , (Europe PMC )0.35 BioGRID, IntAct CLTA Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID CLTB Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID CLTC Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID COP1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 15103385 , 16931761 , 21625211 , 23736031 , 27534417 , (Europe PMC )NA BioGRID COPS2 Affinity Capture-Western physical 16045761 , (Europe PMC )NA BioGRID COPS4 Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 22653443 , 24725084 , (Europe PMC )0.35 BioGRID, IntAct, MINT COPS5 Affinity Capture-Western, Far Western, Reconstituted Complex physical 11285227 , 16624822 , 16936264 , 17879958 , 24725084 , (Europe PMC )NA BioGRID CORO1C Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID COX17 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct CPA5 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID CPNE7 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID CREB1 Affinity Capture-Western, Co-localization, Reconstituted Complex, proximity ligation assay physical, physical association 10848610 , 16611888 , 21295542 , 25241761 , (Europe PMC )0.40 BioGRID, IntAct CREBBP Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-localization, FRET, Phenotypic Suppression, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, competition binding, proximity ligation assay, pull down association, genetic, physical, physical association 10196247 , 10551785 , 10823891 , 10848610 , 11782467 , 12154097 , 12426395 , 14722092 , 14759370 , 15632413 , 16537920 , 17434128 , 18485870 , 18753379 , 19166313 , 19234109 , 19357310 , 19805293 , 19880525 , 20962272 , 21390126 , 22084066 , 23908595 , 25314079 , 25451029 , 26976603 , 27618436 , 9194564 , 9288775 , (Europe PMC )0.91 BioGRID, IntAct, MINT CREBZF Affinity Capture-Western physical 24200963 , (Europe PMC )NA BioGRID CRK Two-hybrid, two hybrid array physical, physical association 25814554 , (Europe PMC )0.37 BioGRID, IntAct CRTC2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID CRYAB Affinity Capture-Western physical 19343786 , 19799611 , (Europe PMC )NA BioGRID CSNK1A1 Affinity Capture-Western physical 19759023 , 27114532 , (Europe PMC )NA BioGRID CSNK1D Affinity Capture-Western, Biochemical Activity, Co-localization, proximity ligation assay physical, physical association 16870621 , 17101137 , 18246126 , 25241761 , (Europe PMC )0.40 BioGRID, IntAct CSNK1E Co-localization, proximity ligation assay physical, physical association 25241761 , (Europe PMC )0.40 BioGRID, IntAct CSNK2A1 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, protein kinase assay, proximity ligation assay phosphorylation reaction, physical, physical association 12628923 , 15358769 , 22975381 , 23443559 , 24725084 , 25241761 , (Europe PMC )0.61 BioGRID, IntAct CSNK2B PCA physical 21675959 , (Europe PMC )NA BioGRID CTBP1 Affinity Capture-Western physical 18765668 , (Europe PMC )NA BioGRID CUL4A Affinity Capture-Western physical 16861890 , (Europe PMC )NA BioGRID CUL4B Affinity Capture-Western physical 24452595 , (Europe PMC )NA BioGRID CUL7 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, molecular sieving, nuclear magnetic resonance, tandem affinity purification association, physical, physical association 16547496 , 16875676 , 17229476 , 17298945 , 17332328 , 17942889 , 22653443 , 23443559 , 24711643 , 25003318 , 25609649 , 26186194 , 28514442 , (Europe PMC )0.72 BioGRID, IntAct, MINT CUL9 Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid association, physical, physical association 12526791 , 16875676 , 17229476 , 17332328 , 17380154 , 18230339 , 21487039 , 22653443 , 23443559 , 25609649 , 26186194 , 28514442 , (Europe PMC )0.72 BioGRID, IntAct, MINT CXCL8 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID CXXC1 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, cross-linking study, pull down association, physical, physical association 23870121 , (Europe PMC )0.60 BioGRID, IntAct CYLD Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 27561390 , (Europe PMC )NA BioGRID CYP20A1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID DAB2IP Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID DACH1 Affinity Capture-Western physical 23798621 , (Europe PMC )NA BioGRID DAPK1 Affinity Capture-Western physical 17339337 , (Europe PMC )NA BioGRID DAPK3 Biochemical Activity physical 15001356 , (Europe PMC )NA BioGRID DAXX Affinity Capture-Western, Co-localization, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy, nuclear magnetic resonance, proximity ligation assay, two hybrid association, colocalization, direct interaction, physical, physical association 12482984 , 12954772 , 14557665 , 15339933 , 15364927 , 16845383 , 21134643 , 21482821 , 23038753 , 25241761 , (Europe PMC )0.44, 0.84 BioGRID, IntAct DBN1 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID DCAF1 Reconstituted Complex physical 22184063 , (Europe PMC )NA BioGRID DCAF7 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID DCLRE1C Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID DDB1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID DDX3X Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID DDX5 Affinity Capture-MS, anti bait coimmunoprecipitation, pull down direct interaction, physical, physical association 15660129 , 20818423 , 23443559 , 24219989 , 25144556 , (Europe PMC )0.44, 0.54, 0.66 BioGRID, IntAct, MINT DDX50 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID DGKZ Affinity Capture-Western, Reconstituted Complex physical 23606744 , (Europe PMC )NA BioGRID DHCR24 Affinity Capture-Western physical 15577914 , (Europe PMC )NA BioGRID DHFR Reconstituted Complex physical 18451149 , (Europe PMC )NA BioGRID DHRS4 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID DKK2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID DLEU1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct DLST Affinity Capture-MS, cross-linking study association, physical 29128334 , (Europe PMC )0.35 BioGRID, IntAct DMTF1 Affinity Capture-Western, Reconstituted Complex physical 22331460 , 28406729 , (Europe PMC )NA BioGRID DNAJA1 Affinity Capture-MS, Affinity Capture-Western physical 23443559 , 25144556 , 27775703 , (Europe PMC )NA BioGRID DNAJA2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID DNAJB1 Affinity Capture-Western physical 24361594 , (Europe PMC )NA BioGRID DNAJB6 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID DNAJC7 Phenotypic Enhancement, Synthetic Growth Defect, Two-hybrid genetic, physical 23261415 , (Europe PMC )NA BioGRID DNMT1 Affinity Capture-Western physical 17991895 , 23038753 , (Europe PMC )NA BioGRID DNMT3L Reconstituted Complex physical 24952347 , (Europe PMC )NA BioGRID DOCK7 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID DOT1L Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID DPH1 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID DPP6 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID DTL Affinity Capture-Western, Biochemical Activity physical 16861890 , (Europe PMC )NA BioGRID DVL2 Two-hybrid, barcode fusion genetics two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid physical, physical association 16189514 , 16713569 , 27107012 , (Europe PMC )0.71 BioGRID, IntAct DZIP1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID E4F1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 10644996 , 12446718 , 16652157 , (Europe PMC )NA BioGRID EBNA1BP2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ECD Affinity Capture-Western physical 23880345 , (Europe PMC )NA BioGRID ECT2 Affinity Capture-MS physical 22990118 , (Europe PMC )NA BioGRID EEA1 Affinity Capture-MS physical 12665691 , (Europe PMC )NA BioGRID EEF1A1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID EEF2 Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 12891704 , 22653443 , (Europe PMC )0.35 BioGRID, IntAct, MINT EFEMP2 Affinity Capture-Western, Two-hybrid physical 10380882 , (Europe PMC )NA BioGRID EGFR Synthetic Growth Defect, Synthetic Lethality genetic 23284306 , 27438146 , (Europe PMC )NA BioGRID EGR1 Affinity Capture-Western, Reconstituted Complex, cosedimentation colocalization, physical 11251186 , 14744935 , 15225550 , 21325822 , (Europe PMC )0.35 BioGRID, IntAct, MINT EHMT1 Biochemical Activity physical 20118233 , 20588255 , (Europe PMC )NA BioGRID EHMT2 Biochemical Activity physical 20118233 , (Europe PMC )NA BioGRID EIF2AK2 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 10348343 , 19631745 , (Europe PMC )NA BioGRID EIF2S2 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct EIF4E2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID EIF5B Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID ELAVL1 Affinity Capture-RNA physical 14517280 , (Europe PMC )NA BioGRID ELL Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 10358050 , (Europe PMC )NA BioGRID ELL3 Affinity Capture-Western, Reconstituted Complex, Synthetic Growth Defect genetic, physical 23284306 , 26540344 , (Europe PMC )NA BioGRID ENAH Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID EP300 Affinity Capture-Luminescence, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-fractionation, Co-localization, Phenotypic Suppression, Protein-peptide, Reconstituted Complex, acetylase assay, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, atomic force microscopy, classical fluorescence spectroscopy, coimmunoprecipitation, isothermal titration calorimetry, nuclear magnetic resonance, pull down, x ray scattering acetylation reaction, association, direct interaction, genetic, physical, physical association 10490106 , 10518217 , 10942770 , 11070080 , 11359905 , 11433299 , 11782467 , 11804596 , 11907332 , 12162806 , 12501250 , 12690203 , 12724314 , 14612423 , 14759370 , 15186775 , 15295102 , 15337767 , 15509808 , 15542844 , 15558054 , 15664194 , 15965232 , 16024799 , 16135789 , 16537920 , 16543236 , 16611888 , 16678111 , 16782091 , 16928824 , 16959611 , 17189186 , 17438265 , 17452980 , 17906639 , 17977830 , 18243116 , 18391200 , 18485870 , 18612383 , 19217391 , 19218448 , 19234109 , 19339993 , 19805293 , 20234175 , 21187340 , 21471221 , 22013068 , 22074660 , 22266186 , 22731250 , 23010591 , 23307557 , 23329847 , 23402884 , 23728348 , 23796514 , 23870121 , 23880760 , 24157709 , 24821727 , 25156994 , 25288747 , 25651062 , 25753752 , 25867071 , 26229107 , 26302407 , 26625199 , 27818144 , 9194564 , 9194565 , 9288740 , 9744860 , 9809062 , 9891054 , (Europe PMC )0.40, 0.97 BioGRID, IntAct, MINT EP400 Affinity Capture-Western physical 9194565 , (Europe PMC )NA BioGRID EPG5 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID EPHA3 Reconstituted Complex physical 15355990 , (Europe PMC )NA BioGRID ERBB4 Affinity Capture-Western physical 20858735 , (Europe PMC )NA BioGRID ERCC2 Far Western, Reconstituted Complex physical 7663514 , 8612585 , (Europe PMC )NA BioGRID ERCC3 Affinity Capture-Western, Reconstituted Complex physical 12379483 , 7663514 , 8612585 , (Europe PMC )NA BioGRID ERCC6 Affinity Capture-Western, Reconstituted Complex physical 10882116 , 22032989 , 7663514 , (Europe PMC )NA BioGRID ERCC8 Affinity Capture-Western physical 22032989 , (Europe PMC )NA BioGRID ERH Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct ERN1 Affinity Capture-Western physical 26254280 , (Europe PMC )NA BioGRID ESR1 Affinity Capture-Western, Reconstituted Complex physical 10766163 , 17545634 , 26556313 , (Europe PMC )NA BioGRID ESS2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ETHE1 Affinity Capture-Western physical 17353187 , (Europe PMC )NA BioGRID ETS1 Affinity Capture-Western physical 14586398 , 18374905 , 24857950 , (Europe PMC )NA BioGRID ETS2 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down direct interaction, physical, physical association 18374905 , 26331536 , 26871468 , (Europe PMC )0.60 BioGRID, IntAct ETV1 Dosage Rescue, Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID EWSR1 Affinity Capture-Western physical 22266186 , (Europe PMC )NA BioGRID EXOSC4 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID EXOSC7 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID EXOSC8 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID FAM111A Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID FAM173A Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct FAU Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID FBL Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID FBXO11 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, enzymatic study, pull down direct interaction, neddylation reaction, physical, physical association 17098746 , (Europe PMC )0.65 BioGRID, IntAct FBXO21 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID FBXO4 Affinity Capture-Western physical 19343786 , (Europe PMC )NA BioGRID FBXO42 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 19509332 , 21127074 , (Europe PMC )NA BioGRID FBXW11 Affinity Capture-MS physical 25515538 , (Europe PMC )NA BioGRID FBXW7 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID FBXW8 Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification association, physical 22653443 , 25609649 , (Europe PMC )0.53 BioGRID, IntAct, MINT FCAMR Two-hybrid, two hybrid physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct FHIT Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID FKBP3 Affinity Capture-Western physical 19166840 , (Europe PMC )NA BioGRID FLNA Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID FOXA3 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXB1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXC1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXG1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXJ3 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXK1 Affinity Capture-MS physical 25609649 , (Europe PMC )NA BioGRID FOXK2 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXN1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXO3 Affinity Capture-RNA, Co-localization physical 25241761 , 27886165 , (Europe PMC )NA BioGRID FOXP1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXQ1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXS1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FTH1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID FXYD6 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct FZR1 Biochemical Activity physical 10922056 , (Europe PMC )NA BioGRID G3BP1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 17297477 , (Europe PMC )NA BioGRID G3BP2 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 17297477 , (Europe PMC )NA BioGRID GABRG3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID GADD45A Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT GAPDH Affinity Capture-Western physical 18552833 , (Europe PMC )NA BioGRID GFPT2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID GIGYF2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID GK2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID GLI1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT GMPS Affinity Capture-Western physical 24462112 , (Europe PMC )NA BioGRID GNB2 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID GNL3 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation physical, physical association 12464630 , 19033382 , (Europe PMC )0.40 BioGRID, IntAct GNL3L Affinity Capture-Western, anti tag coimmunoprecipitation physical, physical association 21132010 , (Europe PMC )0.40 BioGRID, IntAct GOLGA2P5 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID GPATCH8 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID GPR156 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID GPS1 Co-fractionation physical 11285227 , (Europe PMC )NA BioGRID GPS2 Affinity Capture-Western, Reconstituted Complex physical 11486030 , (Europe PMC )NA BioGRID GPSM3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID GPX2 Two-hybrid, two hybrid physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct GRIN2B Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID GRWD1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID GSK3B Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, protein kinase assay, two hybrid phosphorylation reaction, physical, physical association 12048243 , 14744935 , 21900206 , (Europe PMC )0.66 BioGRID, IntAct, MINT GSN Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID GSTM4 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct GTF2H1 Co-crystal Structure, Far Western, Reconstituted Complex, pull down direct interaction, physical 16793543 , 18160537 , 18354501 , 7935417 , 8612585 , (Europe PMC )0.44 BioGRID, IntAct, MINT GTF2H4 Far Western physical 8612585 , (Europe PMC )NA BioGRID GTF2I Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID GTF3C3 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID GTF3C4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID GTPBP4 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID GUCY1A1 Affinity Capture-Western physical 24725084 , (Europe PMC )NA BioGRID H2AFX Affinity Capture-Western physical 16322227 , (Europe PMC )NA BioGRID HABP4 Affinity Capture-Western, Reconstituted Complex physical 16455055 , (Europe PMC )NA BioGRID HADHB Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID HAUS1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID HAUS4 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID HBB Affinity Capture-MS physical 12665691 , (Europe PMC )NA BioGRID HDAC1 Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, proximity ligation assay association, physical, physical association 10521394 , 10777477 , 11099047 , 11313951 , 12426395 , 14976551 , 16107876 , 16697957 , 16959611 , 17827154 , 18765668 , 19011633 , 19303885 , 20075864 , 20633551 , 22266186 , 25241761 , 26539911 , (Europe PMC )0.73 BioGRID, IntAct, MINT HDAC2 Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 14976551 , 17805299 , 17827154 , 20190809 , 20388487 , 21344396 , 22493095 , (Europe PMC )0.35 BioGRID, IntAct HDAC5 Affinity Capture-MS physical 21081666 , (Europe PMC )NA BioGRID HDAC9 Affinity Capture-Western physical 20947501 , (Europe PMC )NA BioGRID HECTD1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID HECTD3 Two-hybrid physical 23358872 , (Europe PMC )NA BioGRID HECW1 Affinity Capture-Western, Reconstituted Complex physical 18223681 , (Europe PMC )NA BioGRID HECW2 Affinity Capture-Western physical 12890487 , (Europe PMC )NA BioGRID HERC2 Affinity Capture-Western, Reconstituted Complex physical 24722987 , 27259994 , (Europe PMC )NA BioGRID HERC5 Affinity Capture-Western physical 25071020 , (Europe PMC )NA BioGRID HEXIM1 Affinity Capture-Western physical 22948151 , (Europe PMC )NA BioGRID HEY1 Reconstituted Complex physical 27129302 , (Europe PMC )NA BioGRID HIF1A Affinity Capture-Western, Reconstituted Complex physical 10640274 , 11593383 , 12124396 , 12606552 , 27345397 , 9537326 , (Europe PMC )NA BioGRID HINFP Two-hybrid, two hybrid physical, physical association 21516116 , (Europe PMC )0.37 BioGRID, IntAct, MINT HINT3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID HIPK1 Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, two hybrid physical, physical association 12702766 , (Europe PMC )0.51 BioGRID, IntAct HIPK2 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down direct interaction, physical, physical association 11740489 , 11925430 , 15896780 , 16212962 , 17349959 , 21057547 , 25313037 , (Europe PMC )0.71 BioGRID, IntAct, MINT HIPK3 Affinity Capture-MS, Two-hybrid, tandem affinity purification physical, physical association 10961991 , 23602568 , (Europe PMC )0.40 BioGRID, IntAct HMGA1 Affinity Capture-Western physical 20335021 , (Europe PMC )NA BioGRID HMGB1 Affinity Capture-Western, Reconstituted Complex, cross-linking study, far western blotting, isothermal titration calorimetry, molecular sieving, nuclear magnetic resonance direct interaction, physical, physical association 11106654 , 11748221 , 23063560 , 9472015 , (Europe PMC )0.74 BioGRID, IntAct HNF4A Affinity Capture-MS, Reconstituted Complex physical 11818510 , 28514442 , (Europe PMC )NA BioGRID HNRNPA1 Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID HNRNPA2B1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID HNRNPF Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID HNRNPH1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID HNRNPK Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down physical, physical association 21821029 , 23092970 , 25144556 , (Europe PMC )0.52, 0.59 BioGRID, IntAct, MINT HNRNPL Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID HNRNPM Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID HNRNPU Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID HOMER3 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID HOXA9 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID HPCA Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID HR Affinity Capture-Western physical 27355563 , (Europe PMC )NA BioGRID HRAS Affinity Capture-Western physical 21041410 , (Europe PMC )NA BioGRID HSP90AA1 Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, nuclear magnetic resonance direct interaction, physical 10557093 , 11297531 , 11507088 , 12427754 , 15001357 , 15358769 , 21268072 , 21460846 , 22939624 , 23443559 , (Europe PMC )0.44 BioGRID, IntAct HSP90AB1 Affinity Capture-MS, luminescence based mammalian interactome mapping physical, physical association 22939624 , 23443559 , (Europe PMC )0.40 BioGRID, IntAct HSP90B1 Affinity Capture-Western, Reconstituted Complex physical 25637791 , (Europe PMC )NA BioGRID HSPA1A Affinity Capture-MS, Affinity Capture-Western physical 23443559 , 25144556 , 7954368 , 8729618 , (Europe PMC )NA BioGRID HSPA1B Affinity Capture-MS, Co-localization physical 25144556 , 25241761 , (Europe PMC )NA BioGRID HSPA1L Affinity Capture-MS, Co-localization, anti bait coimmunoprecipitation, proximity ligation assay physical, physical association 17184779 , 23443559 , 25241761 , (Europe PMC )0.59 BioGRID, IntAct, MINT HSPA2 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID HSPA4 Affinity Capture-Western physical 17184779 , 18223694 , 20847049 , 21268072 , 23109422 , 25144556 , (Europe PMC )NA BioGRID HSPA5 Affinity Capture-MS, Affinity Capture-Western physical 17184779 , 23443559 , (Europe PMC )NA BioGRID HSPA6 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID HSPA8 Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 11297531 , 23443559 , 25144556 , 28215707 , 7954368 , 8729618 , (Europe PMC )NA BioGRID HSPA9 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, direct interaction, physical, physical association 11900485 , 17184779 , 20153329 , 22340593 , 22366412 , 22726440 , 23443559 , 25144556 , (Europe PMC )0.81 BioGRID, IntAct, MINT HSPB1 Affinity Capture-Western, Co-localization, Two-hybrid, anti bait coimmunoprecipitation, proximity ligation assay, two hybrid pooling approach physical, physical association 16169070 , 17184779 , 25241761 , (Europe PMC )0.69 BioGRID, IntAct, MINT HTT Affinity Capture-Western, Reconstituted Complex, biochemical, pull down physical, physical association 10823891 , (Europe PMC )0.52 BioGRID, IntAct, MINT HUWE1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, pull down physical, physical association 15989956 , 22552282 , (Europe PMC )0.52 BioGRID, IntAct HYAL4 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID HYPK Affinity Capture-MS physical 23272104 , (Europe PMC )NA BioGRID ICK Affinity Capture-MS, tandem affinity purification association, physical 23602568 , (Europe PMC )0.35 BioGRID, IntAct IDH3B Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID IFI16 Affinity Capture-Western, anti bait coimmunoprecipitation, classical fluorescence spectroscopy, confocal microscopy, pull down direct interaction, physical, physical association 11146555 , 21397192 , (Europe PMC )0.49, 0.72 BioGRID, IntAct IGF1R Affinity Capture-Western physical 19165858 , (Europe PMC )NA BioGRID IGF2BP1 Affinity Capture-MS, Affinity Capture-Western physical 20308539 , 23443559 , (Europe PMC )NA BioGRID IGF2BP3 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID IKBKB Biochemical Activity, anti bait coimmunoprecipitation, protein kinase assay phosphorylation reaction, physical, physical association 19196987 , 19883646 , (Europe PMC )0.61 BioGRID, IntAct, MINT IL1A Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID IMP3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ING1 Affinity Capture-Western physical 12208736 , 19085961 , 9440695 , (Europe PMC )NA BioGRID ING2 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 16024799 , 16782091 , (Europe PMC )0.40 BioGRID, IntAct, MINT ING4 Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, coimmunoprecipitation physical, physical association 12750254 , 15251430 , 15882981 , 17954561 , 18775696 , 20053357 , 21177815 , 21454715 , 23967213 , (Europe PMC )0.40 BioGRID, IntAct, MINT ING5 Affinity Capture-Western physical 12750254 , 17954561 , 21177815 , (Europe PMC )NA BioGRID INSIG1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID IQGAP1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID IRF7 Two-hybrid physical 18307271 , (Europe PMC )NA BioGRID IRS4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID IRX1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ITCH Affinity Capture-Western, anti bait coimmunoprecipitation association, physical 16908849 , 18559494 , 21474069 , (Europe PMC )0.35 BioGRID, IntAct ITPK1 Biochemical Activity physical 12324474 , (Europe PMC )NA BioGRID ITPKC Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID JMJD8 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID KAT2A Affinity Capture-Western physical 18250150 , (Europe PMC )NA BioGRID KAT2B Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid physical 10490106 , 12068014 , 12501250 , 14614455 , 15965232 , 16537920 , 16678111 , 17189186 , 17977830 , 19680552 , 20589832 , 9744860 , 9891054 , (Europe PMC )NA BioGRID KAT5 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, anti tag coimmunoprecipitation, chromatin immunoprecipitation assay association, physical, physical association 15310756 , 16601686 , 17189186 , 17704809 , 18280244 , 18485870 , 23677994 , (Europe PMC )0.50 BioGRID, IntAct KAT6A Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 19001415 , 23431171 , (Europe PMC )NA BioGRID KAT7 Affinity Capture-Western, Reconstituted Complex physical 17954561 , (Europe PMC )NA BioGRID KAT8 Biochemical Activity, Reconstituted Complex, anti tag coimmunoprecipitation, pull down association, physical, physical association 15960975 , 16601686 , 17189187 , 19854137 , (Europe PMC )0.56 BioGRID, IntAct, MINT KCTD17 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID KDM1A Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, demethylase assay, pull down association, demethylation reaction, direct interaction, physical, physical association 17805299 , 18573881 , 22653443 , (Europe PMC )0.35, 0.66 BioGRID, IntAct, MINT KDM4D Affinity Capture-Western, Two-hybrid physical 22514644 , (Europe PMC )NA BioGRID KDM6A Affinity Capture-Western physical 24078252 , (Europe PMC )NA BioGRID KDR Synthetic Lethality genetic 27438146 , (Europe PMC )NA BioGRID KIAA0087 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct KIF2A Dosage Rescue genetic 20506231 , (Europe PMC )NA BioGRID KIT Positive Genetic genetic 28319113 , (Europe PMC )NA BioGRID KLF5 Affinity Capture-Western physical 16595680 , (Europe PMC )NA BioGRID KLHL40 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID KLRF1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID KMT2A Affinity Capture-MS, Reconstituted Complex, pull down association, physical 15960975 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct KMT2E Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 21423215 , (Europe PMC )0.52 BioGRID, IntAct KMT5A Biochemical Activity physical 17707234 , (Europe PMC )NA BioGRID KPNA4 Affinity Capture-Western, Reconstituted Complex physical 19927155 , (Europe PMC )NA BioGRID KPNB1 Affinity Capture-Western, Reconstituted Complex physical 11297531 , (Europe PMC )NA BioGRID L3MBTL1 Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex physical 20870725 , (Europe PMC )NA BioGRID LAMA4 Co-localization, Two-hybrid, proximity ligation assay, two hybrid pooling approach physical, physical association 16169070 , 25241761 , (Europe PMC )0.57 BioGRID, IntAct LAMTOR5 Affinity Capture-Western, Reconstituted Complex physical 26229107 , (Europe PMC )NA BioGRID LAP3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID LAPTM5 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID LGI4 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID LIMA1 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID LINC01194 Affinity Capture-Western physical 14612521 , (Europe PMC )NA BioGRID LMNA Affinity Capture-MS, pull down association, physical 25144556 , 29568061 , (Europe PMC )0.35 BioGRID, IntAct LRPPRC Affinity Capture-MS, Affinity Capture-Western physical 20308539 , 23443559 , (Europe PMC )NA BioGRID LRRK2 Affinity Capture-Western, Biochemical Activity, tandem affinity purification association, physical 24725412 , 26384650 , (Europe PMC )0.35 BioGRID, IntAct LSM14A Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID LY6G5B Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID LYN Affinity Capture-Western physical 12642697 , (Europe PMC )NA BioGRID LYZ Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID MAD2L1BP Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct MAFK Affinity Capture-Western physical 19011633 , (Europe PMC )NA BioGRID MAGEA2 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, ubiquitinase assay association, direct interaction, physical, physical association, ubiquitination reaction 16847267 , 20864041 , 26468294 , (Europe PMC )0.73 BioGRID, IntAct MAGEB18 Two-hybrid, two hybrid array, two hybrid pooling approach physical, physical association 16189514 , 16713569 , (Europe PMC )0.55 BioGRID, IntAct MAGED2 Affinity Capture-MS, Affinity Capture-Western physical 17912449 , 23443559 , (Europe PMC )NA BioGRID MAP1LC3B Affinity Capture-Western physical 25144556 , (Europe PMC )NA BioGRID MAP3K1 Affinity Capture-Western, Reconstituted Complex physical 20923779 , 26018553 , (Europe PMC )NA BioGRID MAP9 Affinity Capture-Western, Two-hybrid physical 22672907 , (Europe PMC )NA BioGRID MAPK1 Affinity Capture-MS, Affinity Capture-Western, Co-localization, PCA, proximity ligation assay physical, physical association 10958792 , 21147777 , 21675959 , 23443559 , 25241761 , (Europe PMC )0.40 BioGRID, IntAct MAPK10 Affinity Capture-Western physical 9393873 , (Europe PMC )NA BioGRID MAPK14 Affinity Capture-Western, Biochemical Activity, PCA physical 10581258 , 15642743 , 17172861 , 20213747 , 21050851 , 21675959 , (Europe PMC )NA BioGRID MAPK3 Affinity Capture-Western physical 10958792 , 21147777 , 21187340 , (Europe PMC )NA BioGRID MAPK7 Affinity Capture-Western physical 22869143 , (Europe PMC )NA BioGRID MAPK8 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation physical, physical association 11108663 , 12514174 , 15538975 , 15580310 , 18813780 , 19651615 , 9393873 , 9724739 , 9732264 , (Europe PMC )0.40 BioGRID, IntAct, MINT MAPK9 Affinity Capture-Western, Biochemical Activity physical 12384512 , 22366412 , 9393873 , (Europe PMC )NA BioGRID MAPKAPK5 Biochemical Activity, protein kinase assay phosphorylation reaction, physical 17254968 , (Europe PMC )0.44 BioGRID, IntAct MCL1 Affinity Capture-Western, Protein-peptide physical 24491548 , 27818144 , (Europe PMC )NA BioGRID MCM8 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID MDC1 Affinity Capture-Western physical 14519663 , (Europe PMC )NA BioGRID MDH1 Affinity Capture-Western, Reconstituted Complex physical 19229245 , (Europe PMC )NA BioGRID MDM2 Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-RNA, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-fractionation, Co-localization, FRET, Far Western, PCA, Phenotypic Suppression, Protein-RNA, Protein-peptide, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, chromatin immunoprecipitation assay, classical fluorescence spectroscopy, cosedimentation in solution, enzyme linked immunosorbent assay, fluorescence polarization spectroscopy, isothermal titration calorimetry, molecular sieving, nuclear magnetic resonance, peptide array, proximity ligation assay, pull down, surface plasmon resonance, two hybrid, ubiquitinase assay, x-ray crystallography association, direct interaction, genetic, physical, physical association, ubiquitination reaction 10196247 , 10202144 , 10347217 , 10435614 , 10488081 , 10561590 , 10562557 , 10640350 , 10681559 , 10722742 , 10766163 , 10827196 , 10889512 , 10980696 , 11046142 , 11070080 , 11094089 , 11112690 , 11178989 , 11284721 , 11285227 , 11351297 , 11384992 , 11431470 , 11486026 , 11562347 , 11572869 , 11597128 , 11697899 , 11709713 , 11713287 , 11713288 , 11714701 , 11744695 , 11839577 , 11925449 , 12167711 , 12208736 , 12381304 , 12426395 , 12552135 , 12612087 , 12620407 , 12690203 , 12842086 , 12897156 , 12915590 , 12944468 , 14499615 , 14517261 , 14559824 , 14596917 , 14612427 , 14671306 , 14702041 , 14704432 , 14741215 , 15001357 , 15013777 , 15053879 , 15058298 , 15064742 , 15094782 , 15122315 , 15144954 , 15154850 , 15210108 , 15242646 , 15247280 , 15280377 , 15295102 , 15308643 , 15313915 , 15358376 , 15542844 , 15550400 , 15558054 , 15604276 , 15824742 , 15848166 , 15908921 , 15933712 , 15950904 , 16023600 , 16055726 , 16107876 , 1614537 , 16152627 , 16159876 , 16173922 , 16201274 , 16212962 , 16215989 , 16331255 , 16338390 , 16414131 , 16432196 , 16547496 , 16579792 , 16595680 , 16624812 , 16678796 , 16751805 , 16845383 , 16857591 , 16861890 , 16866370 , 16870621 , 16905769 , 16964247 , 17056014 , 17080083 , 17098746 , 17116689 , 17139261 , 17159902 , 17268548 , 17290220 , 17297477 , 17301054 , 17302414 , 17310983 , 17318220 , 17347673 , 17363365 , 17369817 , 17380154 , 17426254 , 17438265 , 17470788 , 17525743 , 17591690 , 17616658 , 17666403 , 17848574 , 17875722 , 17908790 , 17936559 , 17989425 , 18061646 , 18172499 , 18223694 , 18234963 , 18309296 , 18316739 , 18332869 , 18467333 , 18485870 , 18541670 , 18566590 , 18604177 , 18665269 , 18813780 , 18815136 , 18981217 , 19033382 , 19071110 , 19081178 , 19085961 , 19098711 , 19106616 , 19153082 , 19160491 , 19166840 , 19188367 , 19223463 , 19234109 , 19255450 , 19303885 , 19305137 , 19332559 , 19357310 , 19411066 , 19411846 , 19483087 , 19568783 , 19590512 , 19597489 , 19656744 , 19805293 , 19816404 , 19837670 , 19857530 , 19941302 , 20047188 , 20080206 , 20124408 , 20173098 , 20174603 , 20234175 , 20235143 , 20395212 , 20479273 , 20484049 , 20542919 , 20570896 , 20588255 , 20591429 , 20591651 , 20639885 , 20657550 , 20659896 , 20660730 , 20694676 , 20705607 , 20708156 , 20837658 , 20847049 , 20959462 , 20962272 , 21060154 , 21071676 , 21075307 , 21084285 , 21084564 , 21088494 , 21098709 , 21132010 , 21149449 , 21170087 , 21261729 , 21268072 , 21316347 , 21317885 , 21454483 , 21465263 , 21471462 , 21478269 , 21561866 , 21572037 , 21584881 , 21726810 , 21750659 , 21857681 , 21887275 , 21925390 , 21965653 , 21986495 , 21988832 , 22032989 , 22083959 , 22084066 , 22085928 , 22103682 , 22124327 , 22157679 , 22227409 , 22262183 , 22266850 , 22266868 , 22301280 , 22318540 , 22331460 , 22366412 , 22374672 , 22389628 , 22391559 , 22411991 , 22444248 , 22474335 , 22487680 , 22510990 , 22525275 , 22575647 , 22588298 , 22653443 , 22659184 , 22737255 , 22807444 , 22819825 , 22912717 , 22914926 , 22916255 , 22920093 , 22948151 , 22975381 , 23134341 , 23150668 , 23169665 , 23201157 , 23246961 , 23252402 , 23261415 , 23318437 , 23370271 , 23402884 , 23443559 , 23483203 , 23572512 , 23609977 , 23671280 , 23728348 , 23776060 , 23776465 , 23802716 , 23826318 , 23880345 , 23946421 , 24127580 , 24200963 , 24207125 , 24240685 , 24314634 , 24361594 , 24413661 , 24462112 , 24488098 , 24567357 , 24621507 , 24643130 , 24659749 , 24667498 , 24842904 , 24926618 , 24980433 , 24998844 , 25103245 , 25156994 , 25168242 , 25241761 , 25277184 , 25283148 , 25312347 , 25313037 , 25362358 , 25384516 , 25417702 , 25464845 , 25512388 , 25543083 , 25609649 , 25624478 , 25637791 , 25739118 , 25954860 , 26001071 , 26186194 , 26203195 , 26238070 , 26350565 , 26475964 , 26540344 , 26556313 , 26578655 , 26673821 , 26720344 , 26876197 , 26882543 , 26883110 , 26908445 , 27031960 , 27106262 , 27129163 , 27215386 , 27282385 , 27308622 , 27336364 , 27462439 , 27543608 , 27807478 , 27811966 , 27856536 , 27886165 , 27893708 , 28082682 , 28223335 , 28362432 , 28394340 , 28514442 , 28542145 , 28549433 , 28553961 , 28605833 , 7686617 , 7689721 , 8058315 , 8875929 , 9131587 , 9223638 , 9271120 , 9278461 , 9363941 , 9450543 , 9529249 , 9582019 , 9724739 , 9809062 , 9824166 , (Europe PMC )0.99 BioGRID, IntAct, MINT MDM4 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-localization, PCA, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, enzyme linked immunosorbent assay, fluorescence microscopy, fluorescence polarization spectroscopy, isothermal titration calorimetry, nuclear magnetic resonance, pull down, tandem affinity purification, ubiquitinase assay association, colocalization, direct interaction, physical, physical association, ubiquitination reaction 10075736 , 10608892 , 10827196 , 11223036 , 12370303 , 12393902 , 12874296 , 15604276 , 15916963 , 16024788 , 16227609 , 17080083 , 17301054 , 17875722 , 18316739 , 18485870 , 18677113 , 19075013 , 19153082 , 19255450 , 19305137 , 19432880 , 19521340 , 20174603 , 20515689 , 20705607 , 20724842 , 21075307 , 21088494 , 21925390 , 21965653 , 22266850 , 22374672 , 22807444 , 23028042 , 23671280 , 23946421 , 24127580 , 24445145 , 24659749 , 24667498 , 25464845 , 25609649 , 25825738 , 26148237 , 26186194 , 26876197 , 27114532 , 28487147 , 28514442 , 9226370 , (Europe PMC )0.96 BioGRID, IntAct, MINT MED1 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down physical, physical association 11118038 , 15848166 , 9444950 , (Europe PMC )0.52 BioGRID, IntAct, MINT MED17 Reconstituted Complex physical 10198638 , (Europe PMC )NA BioGRID MED21 Reconstituted Complex physical 10024883 , (Europe PMC )NA BioGRID MED22 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID MED8 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID MEN1 Reconstituted Complex, pull down association, physical 15960975 , (Europe PMC )0.35 BioGRID, IntAct MFAP4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MFSD12 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID MIF Affinity Capture-Western physical 18815136 , (Europe PMC )NA BioGRID MKRN1 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down direct interaction, physical, physical association 19536131 , (Europe PMC )0.60 BioGRID, IntAct, MINT MNAT1 Affinity Capture-Western, Reconstituted Complex physical 9372954 , (Europe PMC )NA BioGRID MOGS Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MORN2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID MOV10 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT MPHOSPH6 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct MRPL24 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPL38 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPL39 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPL41 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS14 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS18B Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS22 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT MRPS23 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS25 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS27 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS28 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS5 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS9 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MSH2 Affinity Capture-Western physical 12101417 , 15064730 , (Europe PMC )NA BioGRID MSH6 Affinity Capture-Western physical 15064730 , (Europe PMC )NA BioGRID MSI2 Affinity Capture-Western physical 28223335 , (Europe PMC )NA BioGRID MSL2 Affinity Capture-Western, Reconstituted Complex physical 19033443 , (Europe PMC )NA BioGRID MTA1 Affinity Capture-Western, Co-localization, Reconstituted Complex physical 12920132 , 17914590 , 19837670 , 20071335 , (Europe PMC )NA BioGRID MTA2 Affinity Capture-Western, Reconstituted Complex physical 11099047 , 12920132 , (Europe PMC )NA BioGRID MTHFSD Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID MTOR Affinity Capture-Western, Synthetic Lethality, anti bait coimmunoprecipitation association, genetic, physical 19619545 , 27438146 , (Europe PMC )0.35 BioGRID, IntAct, MINT MUC1 Affinity Capture-Western, Co-localization, Reconstituted Complex physical 15710329 , (Europe PMC )NA BioGRID MUL1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 21597459 , (Europe PMC )NA BioGRID MVP Two-hybrid physical 24722188 , (Europe PMC )NA BioGRID MYBBP1A Reconstituted Complex physical 21471221 , (Europe PMC )NA BioGRID MYBPC1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID MYC Affinity Capture-MS, tandem affinity purification association, physical 21150319 , (Europe PMC )0.35 BioGRID, IntAct MYH9 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID MYL9 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID MYLK Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID MYO1C Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID MYO6 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID MYOT Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID MZT2B Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID NABP1 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct NABP2 Affinity Capture-Western, Reconstituted Complex physical 23184057 , (Europe PMC )NA BioGRID NAT10 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 26882543 , (Europe PMC )NA BioGRID NCL Affinity Capture-Western, Far Western, Reconstituted Complex, far western blotting, pull down direct interaction, physical 12138209 , 22103682 , 26238070 , (Europe PMC )0.56 BioGRID, IntAct, MINT NCOA1 Reconstituted Complex, Two-hybrid physical 10551785 , (Europe PMC )NA BioGRID NCOA2 Reconstituted Complex, display technology physical, physical association 20195357 , (Europe PMC )0.40 BioGRID, IntAct NCOA3 Reconstituted Complex physical 10551785 , (Europe PMC )NA BioGRID NCOR1 Affinity Capture-Western, Co-localization physical 19011633 , 24157709 , (Europe PMC )NA BioGRID NDN Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 10347180 , 18753379 , 23785149 , 24722188 , (Europe PMC )NA BioGRID NDRG4 Affinity Capture-Western physical 26053091 , (Europe PMC )NA BioGRID NEIL3 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct NELFCD Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID NEUROG2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID NFATC1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT NFKBIA Affinity Capture-Western, Two-hybrid physical 11799106 , (Europe PMC )NA BioGRID NFYA Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, imaging technique association, colocalization, physical, physical association 15831478 , 16959611 , 23908595 , (Europe PMC )0.54 BioGRID, IntAct NFYB Affinity Capture-Western, anti bait coimmunoprecipitation association, physical, physical association 15831478 , 16959611 , 23734815 , (Europe PMC )0.56 BioGRID, IntAct NGFR Affinity Capture-Western, Reconstituted Complex physical 27282385 , (Europe PMC )NA BioGRID NIN Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct NINL Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct NLK Affinity Capture-Western, Phenotypic Enhancement, Reconstituted Complex genetic, physical 24926618 , (Europe PMC )NA BioGRID NME4 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID NMT1 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 16530191 , (Europe PMC )0.40 BioGRID, IntAct, MINT NMT2 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 16530191 , (Europe PMC )0.40 BioGRID, IntAct, MINT NOC2L Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, tandem affinity purification association, direct interaction, physical, physical association 16322561 , 20959462 , (Europe PMC )0.63 BioGRID, IntAct NOP53 Affinity Capture-Western, Reconstituted Complex physical 22522597 , (Europe PMC )NA BioGRID NOTCH4 Affinity Capture-Western physical 21402876 , (Europe PMC )NA BioGRID NPAS3 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT NPIPB13 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID NPM1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, coimmunoprecipitation, cross-linking study, surface plasmon resonance association, direct interaction, physical, physical association 12080348 , 15144954 , 15964625 , 16376884 , 16740634 , 23443559 , (Europe PMC )0.35, 0.56, 0.68 BioGRID, IntAct, MINT NPRL3 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID NQO1 Affinity Capture-Western physical 14634213 , 26078718 , 26540344 , (Europe PMC )NA BioGRID NR0B2 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 22575647 , 22737255 , (Europe PMC )0.52 BioGRID, IntAct, MINT NR1I2 Affinity Capture-MS, Affinity Capture-Western physical 23536728 , (Europe PMC )NA BioGRID NR3C1 Affinity Capture-Western, Reconstituted Complex physical 11080152 , 11562347 , (Europe PMC )NA BioGRID NR4A1 Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down, two hybrid array physical, physical association 17139261 , (Europe PMC )0.58 BioGRID, IntAct, MINT NT5C3A Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID NUB1 Affinity Capture-Western physical 20101219 , (Europe PMC )NA BioGRID NUMB Affinity Capture-Western physical 18172499 , 22157679 , 23881403 , 27106262 , 28223335 , (Europe PMC )NA BioGRID OBSL1 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, tandem affinity purification association, physical 22653443 , 23443559 , 24711643 , 25609649 , (Europe PMC )0.53 BioGRID, IntAct, MINT OFD1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct OLIG2 Phenotypic Suppression genetic 21397859 , (Europe PMC )NA BioGRID OTUB1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, direct interaction, physical, physical association 22124327 , 24403071 , 27561390 , (Europe PMC )0.63 BioGRID, IntAct, MINT OTUD1 Affinity Capture-Western physical 28216291 , (Europe PMC )NA BioGRID OTUD5 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation physical, physical association 19615732 , 24143256 , 25499082 , (Europe PMC )0.40 BioGRID, IntAct PABPC1 Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID PACRG Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PADI1 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct PADI4 Affinity Capture-Western, Co-localization, Reconstituted Complex physical 18505818 , 20190809 , (Europe PMC )NA BioGRID PAFAH1B3 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct PAN2 Affinity Capture-MS physical 23398456 , (Europe PMC )NA BioGRID PARK7 Affinity Capture-Western physical 18042550 , 22683601 , (Europe PMC )NA BioGRID PARP1 Affinity Capture-Western, Far Western, Reconstituted Complex, anti bait coimmunoprecipitation, coimmunoprecipitation, pull down association, direct interaction, physical, physical association 12898523 , 14627987 , 15044383 , 9312059 , 9565608 , (Europe PMC )0.75 BioGRID, IntAct, MINT PATZ1 Affinity Capture-Western, Reconstituted Complex physical 24336083 , 25755280 , (Europe PMC )NA BioGRID PCBP1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PCDHA4 Two-hybrid physical 16169070 , (Europe PMC )NA BioGRID PCMT1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PCNA Affinity Capture-Western, Co-localization physical 16861890 , 27407148 , (Europe PMC )NA BioGRID PDCD5 Affinity Capture-Western, Co-localization, Reconstituted Complex physical 22914926 , 25499082 , (Europe PMC )NA BioGRID PDCD6 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PDHA1 Affinity Capture-MS, cross-linking study association, physical 29128334 , (Europe PMC )0.35 BioGRID, IntAct PDIA5 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PDLIM7 Affinity Capture-Western, Reconstituted Complex physical 21060154 , (Europe PMC )NA BioGRID PER2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 25103245 , 27834218 , (Europe PMC )NA BioGRID PES1 Affinity Capture-MS physical 25609649 , (Europe PMC )NA BioGRID PHB Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy, fluorescence microscopy colocalization, physical, physical association 14500729 , 16319068 , 20134482 , 24380853 , (Europe PMC )0.62 BioGRID, IntAct, MINT PHF1 Affinity Capture-MS, Affinity Capture-Western, tandem affinity purification association, physical 18385154 , 23150668 , 27705803 , (Europe PMC )0.35 BioGRID, IntAct PHF20 Affinity Capture-Western physical 22864287 , (Europe PMC )NA BioGRID PHKA2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PHKB Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PHKG2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PHYH Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PIAS1 Biochemical Activity, Co-localization, Reconstituted Complex, Two-hybrid, proximity ligation assay, pull down direct interaction, physical, physical association 10380882 , 11583632 , 11867732 , 15133049 , 20805487 , 25241761 , (Europe PMC )0.61 BioGRID, IntAct PIAS2 Biochemical Activity, Co-localization, Reconstituted Complex, Two-hybrid, proximity ligation assay, two hybrid physical, physical association 11867732 , 18624398 , 19339993 , 25241761 , (Europe PMC )0.57 BioGRID, IntAct PIAS4 Two-hybrid, anti bait coimmunoprecipitation, two hybrid physical, physical association 11388671 , 15383276 , (Europe PMC )0.51 BioGRID, IntAct PIN1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, chromatin immunoprecipitation assay, coimmunoprecipitation, pull down, two hybrid association, physical, physical association 12388558 , 12397362 , 17906639 , 21741598 , 21900206 , (Europe PMC )0.85 BioGRID, IntAct, MINT PIWIL1 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID PKIA Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PLAC8 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PLAGL1 Phenotypic Enhancement, Reconstituted Complex genetic, physical 11360197 , (Europe PMC )NA BioGRID PLCG2 Two-hybrid, two hybrid array, validated two hybrid physical, physical association 25814554 , (Europe PMC )0.49 BioGRID, IntAct PLK1 Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay, two hybrid association, phosphorylation reaction, physical, physical association 16753148 , 19833129 , 22653443 , (Europe PMC )0.74 BioGRID, IntAct, MINT PLK3 Affinity Capture-Western, Biochemical Activity physical 11551930 , 12242661 , (Europe PMC )NA BioGRID PML Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy, imaging technique, proximity ligation assay association, colocalization, physical, physical association 11025664 , 11080164 , 12006491 , 12915590 , 14976551 , 15375079 , 16007146 , 20972456 , 21057547 , 22869143 , 25241761 , (Europe PMC )0.49, 0.72 BioGRID, IntAct PNP Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct POLA1 Affinity Capture-Western physical 11917009 , (Europe PMC )NA BioGRID POLD3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID POLDIP2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID POLI Affinity Capture-Western, Co-localization physical 27407148 , (Europe PMC )NA BioGRID POLR1D Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID POLRMT Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT PPA1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct PPARGC1A Affinity Capture-Western, Reconstituted Complex physical 22099309 , (Europe PMC )NA BioGRID PPFIBP1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PPP1CA Two-hybrid, two hybrid physical, physical association 15231748 , (Europe PMC )0.37 BioGRID, IntAct, MINT PPP1CC Affinity Capture-Western, anti bait coimmunoprecipitation, antibody array physical, physical association 17274640 , (Europe PMC )0.52 BioGRID, IntAct PPP1R12A Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID PPP1R13B Affinity Capture-Western, Synthetic Growth Defect, anti bait coimmunoprecipitation association, genetic, physical 21513714 , 23284306 , (Europe PMC )0.35 BioGRID, IntAct, MINT PPP1R13L Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, fluorescence microscopy, pull down, solid phase assay association, colocalization, direct interaction, physical, physical association 12524540 , 17906639 , 18275817 , 20840860 , 21513714 , 23443559 , 23623661 , (Europe PMC )0.81 BioGRID, IntAct, MINT PPP2R1A Affinity Capture-MS, Co-localization, anti bait coimmunoprecipitation, proximity ligation assay, pull down physical, physical association 12665691 , 17245430 , 25241761 , (Europe PMC )0.66 BioGRID, IntAct, MINT PPP2R5C Co-localization, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, proximity ligation assay association, physical, physical association 17245430 , 21460856 , 25241761 , (Europe PMC )0.35, 0.69 BioGRID, IntAct, MINT PPP3CA Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PPP3R1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PPP4C Reconstituted Complex physical 9837938 , (Europe PMC )NA BioGRID PRAM1 Affinity Capture-Western physical 14976551 , (Europe PMC )NA BioGRID PRDM2 Affinity Capture-Western physical 20594067 , (Europe PMC )NA BioGRID PRKCD Affinity Capture-Western, anti bait coimmunoprecipitation, protein kinase assay, pull down phosphorylation reaction, physical, physical association 16314418 , 16377624 , (Europe PMC )0.60 BioGRID, IntAct PRKD1 Biochemical Activity physical 12628923 , (Europe PMC )NA BioGRID PRKDC Affinity Capture-Western, Biochemical Activity, Protein-peptide physical 10608806 , 10713094 , 12756247 , 19918261 , 25362358 , 9363941 , 9679063 , 9744860 , (Europe PMC )NA BioGRID PRKN Biochemical Activity, Reconstituted Complex physical 28395174 , (Europe PMC )NA BioGRID PRMT1 Reconstituted Complex physical 15186775 , (Europe PMC )NA BioGRID PRMT3 Affinity Capture-Western physical 21942715 , (Europe PMC )NA BioGRID PRMT5 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID PRPF6 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PRRC2A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PRRC2C Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PSD3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PSMB3 Biochemical Activity physical 20080206 , (Europe PMC )NA BioGRID PSMC3 Affinity Capture-Western physical 20479273 , (Europe PMC )NA BioGRID PSMC5 Affinity Capture-Western, Reconstituted Complex physical 17224908 , 20479273 , (Europe PMC )NA BioGRID PSMD10 Affinity Capture-Western physical 16023600 , (Europe PMC )NA BioGRID PSMD11 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct PSMD4 Affinity Capture-Western physical 20479273 , (Europe PMC )NA BioGRID PSMD6 Affinity Capture-Western physical 24258024 , (Europe PMC )NA BioGRID PSME3 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, physical, physical association 18309296 , 21084564 , (Europe PMC )0.58 BioGRID, IntAct, MINT PTCD3 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PTEN Affinity Capture-Western, Reconstituted Complex physical 12620407 , 14559824 , 18339852 , 24141722 , (Europe PMC )NA BioGRID PTGS2 Affinity Capture-Western, Co-purification, Reconstituted Complex physical 11687965 , 15707991 , 16928824 , 19465063 , 21187340 , (Europe PMC )NA BioGRID PTK2 Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy, proximity ligation assay, pull down colocalization, direct interaction, physical, physical association 15855171 , 18206965 , 19857493 , 25241761 , (Europe PMC )0.76 BioGRID, IntAct, MINT PTTG1 Affinity Capture-Western, Reconstituted Complex physical 12355087 , 19117984 , (Europe PMC )NA BioGRID PTTG1IP Affinity Capture-Western, Reconstituted Complex, Synthetic Growth Defect genetic, physical 23284306 , 24506068 , 25408419 , (Europe PMC )NA BioGRID PTX3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PURG Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID RAB4A Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct RAB7A Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID RABL6 Affinity Capture-Western physical 23572512 , (Europe PMC )NA BioGRID RAD23A Affinity Capture-Western physical 15064742 , 16105547 , (Europe PMC )NA BioGRID RAD51 Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, coimmunoprecipitation physical, physical association 14636569 , 15064730 , 16983346 , 26140185 , 8617246 , 9380510 , (Europe PMC )0.40 BioGRID, IntAct RAE1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RANBP2 Biochemical Activity physical 22194619 , (Europe PMC )NA BioGRID RANBP9 Two-hybrid, anti tag coimmunoprecipitation association, physical 18307271 , 22653443 , (Europe PMC )0.35 BioGRID, IntAct, MINT RAP1B Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT RAVER1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RB1 Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 20871633 , 8083962 , (Europe PMC )0.35 BioGRID, IntAct RB1CC1 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 20614030 , 21775823 , (Europe PMC )0.40 BioGRID, IntAct RBBP4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RBBP5 Affinity Capture-Western, Reconstituted Complex, Synthetic Growth Defect, anti tag coimmunoprecipitation, pull down association, genetic, physical 15960975 , 19433796 , 23284306 , 23870121 , (Europe PMC )0.69 BioGRID, IntAct RBBP6 Affinity Capture-Western, Reconstituted Complex physical 9010216 , (Europe PMC )NA BioGRID RBBP7 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RBM3 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RBM39 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RBPJ Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, microscale thermophoresis direct interaction, physical, physical association 26302407 , (Europe PMC )0.65 BioGRID, IntAct RBX1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT RCC1 Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT RCHY1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, imaging technique, nuclear magnetic resonance, pull down, two hybrid colocalization, direct interaction, physical, physical association 12654245 , 17568776 , 19043414 , 19483087 , 20452352 , 21084285 , 21791603 , 21988832 , 24367557 , 25116336 , (Europe PMC )0.85 BioGRID, IntAct, MINT RCN2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RDH13 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RECQL5 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID RELA Affinity Capture-Western physical 17434128 , (Europe PMC )NA BioGRID RETNLB Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID REV1 Affinity Capture-Western physical 25614517 , (Europe PMC )NA BioGRID RFC1 Affinity Capture-Western physical 12509469 , (Europe PMC )NA BioGRID RFC3 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RFC4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RFFL Affinity Capture-Western physical 17121812 , 18382127 , (Europe PMC )NA BioGRID RFWD3 Affinity Capture-Western, Reconstituted Complex physical 20173098 , (Europe PMC )NA BioGRID RING1 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy, pull down, ubiquitinase assay colocalization, physical, physical association, ubiquitination reaction 22907436 , 29187402 , (Europe PMC )0.65 BioGRID, IntAct RMDN1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID RNASE4 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID RNASEL Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT RNF125 Affinity Capture-Western, Reconstituted Complex physical 25591766 , (Europe PMC )NA BioGRID RNF128 Reconstituted Complex, Two-hybrid physical 23370271 , (Europe PMC )NA BioGRID RNF2 Affinity Capture-Western physical 22907436 , 23318437 , (Europe PMC )NA BioGRID RNF20 Affinity Capture-Western, Reconstituted Complex, pull down association, physical 16337599 , 19410543 , (Europe PMC )0.35 BioGRID, IntAct RNF34 Affinity Capture-Western physical 17121812 , (Europe PMC )NA BioGRID RNF38 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 20308539 , 23973461 , (Europe PMC )NA BioGRID RNF39 Affinity Capture-Western physical 17719541 , (Europe PMC )NA BioGRID RNF43 Affinity Capture-Western physical 21108931 , (Europe PMC )NA BioGRID RORC Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID RPA1 Affinity Capture-Western, Reconstituted Complex, enzyme linked immunosorbent assay physical, physical association 11751427 , 15489903 , 15735006 , 23267009 , (Europe PMC )0.40 BioGRID, IntAct RPA2 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT RPGRIP1L Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct RPL10A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL10L Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL11 Affinity Capture-MS, Affinity Capture-Western physical 14612427 , 15308643 , 23169665 , 23443559 , (Europe PMC )NA BioGRID RPL12 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL13 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL14 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL15 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL18 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL18A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL19 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL21 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL23 Affinity Capture-MS, Affinity Capture-Western physical 15308643 , 23443559 , (Europe PMC )NA BioGRID RPL23A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL24 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL26 Affinity Capture-MS, Affinity Capture-Western physical 20542919 , 23443559 , (Europe PMC )NA BioGRID RPL26L1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL27 Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID RPL27AP6 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL28 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RPL29P11 Affinity Capture-MS physical 25609649 , (Europe PMC )NA BioGRID RPL3 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL30 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL31 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL36P14 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID RPL37A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL4 Affinity Capture-MS, Affinity Capture-Western physical 23443559 , 26908445 , (Europe PMC )NA BioGRID RPL5 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 15308643 , 22653443 , 23169665 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT RPL6 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL7 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL7A Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID RPL8 Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID RPLP0 Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID RPLP2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPRD1A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS10 Affinity Capture-MS, Two-hybrid physical 15536084 , 23443559 , (Europe PMC )NA BioGRID RPS13 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RPS14 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS15 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS15P2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS16 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RPS17 Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID RPS18 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RPS19 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RPS2 Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID RPS24 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS25 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS26 Affinity Capture-MS, Affinity Capture-Western physical 23443559 , 23728348 , (Europe PMC )NA BioGRID RPS27 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS27A Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 21561866 , 22653443 , (Europe PMC )0.35 BioGRID, IntAct, MINT RPS3 FRET, fluorescent resonance energy transfer, proximity ligation assay, pull down association, direct interaction, physical, physical association 19656744 , (Europe PMC )0.63 BioGRID, IntAct RPS3A Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID RPS4X Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RPS6 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS7 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 17310983 , 19683495 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct RPS8 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS9 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPUSD4 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID RRM2 Affinity Capture-Western physical 12615712 , (Europe PMC )NA BioGRID RRM2B Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical, physical association 12615712 , 19015526 , (Europe PMC )0.35, 0.40 BioGRID, IntAct RRP1B Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RUNX2 Affinity Capture-Western physical 23618908 , (Europe PMC )NA BioGRID RYBP Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical, physical association 19098711 , (Europe PMC )0.50 BioGRID, IntAct, MINT RYK Affinity Capture-MS physical 21875946 , (Europe PMC )NA BioGRID S100A4 Affinity Capture-Western, Reconstituted Complex, confocal microscopy, cross-linking study, far western blotting, fluorescence polarization spectroscopy, molecular sieving, proximity ligation assay colocalization, direct interaction, physical, physical association 11527429 , 19740107 , 20070253 , 20591429 , 23752197 , (Europe PMC )0.79 BioGRID, IntAct, MINT S100A6 Reconstituted Complex, molecular sieving direct interaction, physical 20591429 , 23796514 , (Europe PMC )0.44 BioGRID, IntAct, MINT S100A8 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct S100B Affinity Capture-Western, molecular sieving direct interaction, physical 15178678 , 20591429 , (Europe PMC )0.44 BioGRID, IntAct, MINT SACS Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SAFB Affinity Capture-Western, anti bait coimmunoprecipitation, fluorescence microscopy, pull down colocalization, physical, physical association 21130767 , (Europe PMC )0.56 BioGRID, IntAct, MINT SAFB2 Affinity Capture-Western, pull down physical, physical association 21130767 , (Europe PMC )0.40 BioGRID, IntAct, MINT SAMD7 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SART1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID SAT1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct SBF2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SCAMP1 Two-hybrid, two hybrid array physical, physical association 16713569 , (Europe PMC )0.37 BioGRID, IntAct SCO2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID SEC63 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SENP1 Affinity Capture-Western physical 19339993 , (Europe PMC )NA BioGRID SENP3 Affinity Capture-Western, Co-localization physical 21316347 , (Europe PMC )NA BioGRID SERBP1 Affinity Capture-Western physical 16455055 , (Europe PMC )NA BioGRID SERPINB9 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct SERPINH1 Affinity Capture-Western physical 17977830 , (Europe PMC )NA BioGRID SET Affinity Capture-Western, Reconstituted Complex physical 21911363 , (Europe PMC )NA BioGRID SETD1A Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, physical 23870121 , (Europe PMC )0.53 BioGRID, IntAct SETD2 Affinity Capture-Western physical 18585004 , (Europe PMC )NA BioGRID SETD7 Biochemical Activity, Co-crystal Structure, Two-hybrid, competition binding, enzymatic study, methyltransferase assay, methyltransferase radiometric assay, pull down, two hybrid, x-ray crystallography direct interaction, methylation reaction, physical, physical association 15525938 , 16415881 , 17108971 , 17805299 , 21245319 , 21988832 , (Europe PMC )0.92 BioGRID, IntAct SF3B2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID SFN Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, isothermal titration calorimetry, x-ray crystallography association, direct interaction, physical 11896572 , 14517281 , 17546054 , 20206173 , 21625211 , (Europe PMC )0.67 BioGRID, IntAct, MINT SIN3A Affinity Capture-Western, Reconstituted Complex physical 10521394 , 11359905 , (Europe PMC )NA BioGRID SIN3B Affinity Capture-Western, Two-hybrid physical 22028823 , (Europe PMC )NA BioGRID SIRT1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, acetylase assay, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, deacetylase assay, pull down association, deacetylation reaction, direct interaction, physical, physical association, physical interaction 11672523 , 12006491 , 15205477 , 17964266 , 18235501 , 18235502 , 18753379 , 21149449 , 21245319 , 22389628 , 22689577 , 22735644 , (Europe PMC )0.96 BioGRID, IntAct SIRT7 Affinity Capture-MS physical 22586326 , (Europe PMC )NA BioGRID SIVA1 Affinity Capture-Western physical 19590512 , 25431847 , (Europe PMC )NA BioGRID SKI Affinity Capture-Western physical 21149449 , (Europe PMC )NA BioGRID SKP1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT SLAMF1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SLC25A5 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID SLC2A12 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID SLC7A2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SLC9A9 Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID SMAD1 Affinity Capture-Western physical 22588298 , (Europe PMC )NA BioGRID SMAD2 Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, proximity ligation assay physical, physical association 12732139 , 19345189 , 19580641 , 23687300 , 25241761 , 25670079 , (Europe PMC )0.70 BioGRID, IntAct SMAD3 Affinity Capture-Western, Co-localization, Reconstituted Complex physical 12732139 , 23687300 , 24157709 , (Europe PMC )NA BioGRID SMAD7 Affinity Capture-Western physical 17172861 , (Europe PMC )NA BioGRID SMARCA4 Affinity Capture-Western, Co-fractionation, Reconstituted Complex, anti bait coimmunoprecipitation association, physical 11950834 , 17666433 , 18303029 , 21900401 , (Europe PMC )0.35 BioGRID, IntAct SMARCA5 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT SMARCB1 Affinity Capture-Western, Co-fractionation, Reconstituted Complex physical 11950834 , (Europe PMC )NA BioGRID SMARCC1 Affinity Capture-Western, Co-fractionation, anti bait coimmunoprecipitation association, physical 11950834 , 18303029 , (Europe PMC )0.35 BioGRID, IntAct SMARCD1 Affinity Capture-Western physical 18303029 , (Europe PMC )NA BioGRID SMARCD2 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID SMG5 Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification association, physical 22653443 , 25609649 , (Europe PMC )0.53 BioGRID, IntAct, MINT SMG7 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 22653443 , 27462439 , (Europe PMC )0.35 BioGRID, IntAct, MINT SMN1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid physical, physical association 11704667 , 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT SMURF1 Affinity Capture-Western physical 20484049 , (Europe PMC )NA BioGRID SMYD2 Affinity Capture-Western, Biochemical Activity, isothermal titration calorimetry, methyltransferase assay, methyltransferase radiometric assay, tandem affinity purification, x-ray crystallography adp ribosylation reaction, direct interaction, methylation reaction, physical 17108971 , 17805299 , 18065756 , 21782458 , 25609649 , (Europe PMC )0.81 BioGRID, IntAct, MINT SNAI1 Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 20385133 , 28067227 , (Europe PMC )0.52 BioGRID, IntAct, MINT SNAI2 Affinity Capture-MS physical 23851495 , (Europe PMC )NA BioGRID SNRPD3 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID SNRPN Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct SNW1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID SNX12 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SOCS1 Affinity Capture-Western, Reconstituted Complex physical 20005840 , (Europe PMC )NA BioGRID SOX4 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down physical, physical association 19234109 , (Europe PMC )0.59 BioGRID, IntAct SP1 Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation physical, physical association 12665570 , 15574328 , 15674334 , 15710382 , 16740634 , 18765668 , 19846904 , 20570896 , 21325822 , 21831840 , 23650532 , 8463313 , 9492043 , 9685344 , (Europe PMC )0.59 BioGRID, IntAct, MINT SP3 Affinity Capture-Western physical 12665570 , (Europe PMC )NA BioGRID SPESP1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SPICE1 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct SPSB1 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID SQSTM1 Affinity Capture-Western, Reconstituted Complex physical 16793543 , 25144556 , 27031960 , (Europe PMC )NA BioGRID SRC Biochemical Activity physical 25071020 , (Europe PMC )NA BioGRID SRPK1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 21130767 , (Europe PMC )NA BioGRID SRSF1 Affinity Capture-Western, Biochemical Activity physical 20805487 , (Europe PMC )NA BioGRID SRSF6 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID SSX2IP Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct STAM2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID STAMBP Biochemical Activity physical 27561390 , (Europe PMC )NA BioGRID STARD10 Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID STAT6 Two-hybrid physical 20121258 , (Europe PMC )NA BioGRID STK11 Affinity Capture-Western, chromatin immunoprecipitation assay association, physical 11430832 , 21317932 , (Europe PMC )0.35 BioGRID, IntAct STK4 Co-localization, proximity ligation assay physical, physical association 25241761 , (Europe PMC )0.40 BioGRID, IntAct STT3B Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID STUB1 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 15001357 , 15911628 , 17666403 , 18223694 , 20618441 , 21268072 , 22254155 , 23134341 , 25144556 , 25543083 , 26330542 , 27775703 , 27807478 , (Europe PMC )NA BioGRID STX2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID STX5 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct STXBP4 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SULT1E1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct SUMO1 Two-hybrid, comigration in sds page, pull down covalent binding, direct interaction, physical, physical association 10961991 , 16732283 , 19684601 , 20534433 , (Europe PMC )0.72 BioGRID, IntAct SUPT3H Affinity Capture-Western, Synthetic Growth Defect genetic, physical 18250150 , 23284306 , (Europe PMC )NA BioGRID SUPT6H Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID SUPT7L Affinity Capture-Western physical 18250150 , (Europe PMC )NA BioGRID SYVN1 Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, imaging technique, pull down colocalization, physical, physical association 17170702 , 21903092 , 26254280 , (Europe PMC )0.61 BioGRID, IntAct, MINT TADA1 Affinity Capture-Western physical 18250150 , (Europe PMC )NA BioGRID TADA2A Affinity Capture-Western physical 18250150 , (Europe PMC )NA BioGRID TADA3 Affinity Capture-MS, Affinity Capture-Western physical 11707411 , 17272277 , 17452980 , 18250150 , 23443559 , (Europe PMC )NA BioGRID TAF1 Affinity Capture-Western, Biochemical Activity physical 10359315 , 15053879 , (Europe PMC )NA BioGRID TAF10 Affinity Capture-Western physical 18250150 , (Europe PMC )NA BioGRID TAF1A Reconstituted Complex physical 10913176 , (Europe PMC )NA BioGRID TAF1B Reconstituted Complex physical 10913176 , (Europe PMC )NA BioGRID TAF1C Reconstituted Complex physical 10913176 , (Europe PMC )NA BioGRID TAF5 Affinity Capture-Western physical 15053879 , (Europe PMC )NA BioGRID TAF5L Affinity Capture-Western physical 18250150 , (Europe PMC )NA BioGRID TAF6 Affinity Capture-Western, Reconstituted Complex physical 20096117 , (Europe PMC )NA BioGRID TAF9 Affinity Capture-Western, Reconstituted Complex physical 11278372 , 18250150 , 7761466 , (Europe PMC )NA BioGRID TBC1D24 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID TBC1D4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TBP Affinity Capture-Western, Reconstituted Complex, far western blotting, pull down direct interaction, physical, physical association 10359315 , 11313951 , 12379483 , 1465435 , 7799929 , 8083962 , 9349482 , (Europe PMC )0.40, 0.44 BioGRID, IntAct, MINT TBPL1 Affinity Capture-Western, Reconstituted Complex physical 28082682 , (Europe PMC )NA BioGRID TCEAL1 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID TCEAL4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TCF4 Affinity Capture-MS, Reconstituted Complex, pull down, tandem affinity purification association, physical, physical association 25402006 , 25609649 , (Europe PMC )0.56 BioGRID, IntAct, MINT TCP1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT TDG Two-hybrid physical 10961991 , (Europe PMC )NA BioGRID TEP1 Reconstituted Complex physical 10597287 , (Europe PMC )NA BioGRID TERT Dosage Rescue, Phenotypic Enhancement genetic 23284306 , (Europe PMC )NA BioGRID TFAP2A Affinity Capture-Western, Co-localization, Reconstituted Complex, Two-hybrid physical 12226108 , 16288208 , (Europe PMC )NA BioGRID TFAP2B Affinity Capture-Western physical 20159018 , (Europe PMC )NA BioGRID TFAP2C Reconstituted Complex physical 12226108 , (Europe PMC )NA BioGRID TFAP4 Affinity Capture-Western physical 19505873 , (Europe PMC )NA BioGRID TFDP1 Affinity Capture-Western, Reconstituted Complex physical 8816502 , (Europe PMC )NA BioGRID TFIP11 Affinity Capture-Western, Reconstituted Complex physical 26460617 , (Europe PMC )NA BioGRID TFRC Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TGM2 Affinity Capture-Western physical 27031960 , (Europe PMC )NA BioGRID THAP1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID THAP12 Reconstituted Complex physical 12384512 , (Europe PMC )NA BioGRID THAP8 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct THRAP3 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID THRB Affinity Capture-Western physical 11258898 , (Europe PMC )NA BioGRID TIMM50 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TK1 Two-hybrid, two hybrid, two hybrid pooling approach physical, physical association 16169070 , 21900206 , (Europe PMC )0.55 BioGRID, IntAct, MINT TMED9 Co-fractionation physical 9472029 , (Europe PMC )NA BioGRID TMEM200A Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID TNFAIP3 Affinity Capture-Western physical 23471665 , 24099634 , (Europe PMC )NA BioGRID TNK2 Affinity Capture-Western physical 23402884 , (Europe PMC )NA BioGRID TOM1L1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID TOP1 Affinity Capture-Western, Two-hybrid physical 10468612 , 11805286 , 18697815 , (Europe PMC )NA BioGRID TOP1MT Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct TOP2A Affinity Capture-Western, Reconstituted Complex, Synthetic Growth Defect genetic, physical 10666337 , 23284306 , (Europe PMC )NA BioGRID TOP2B Affinity Capture-Western, Reconstituted Complex physical 10666337 , (Europe PMC )NA BioGRID TOPORS Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation physical, physical association 11842245 , 15247280 , 16122737 , 17290218 , 17803295 , (Europe PMC )0.40 BioGRID, IntAct, MINT TOR1AIP2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TP53 Affinity Capture-Western, Co-crystal Structure, Co-fractionation, Co-purification, FRET, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, comigration in gel electrophoresis, comigration in non denaturing gel electrophoresis, cosedimentation in solution, cross-linking study, electron microscopy, mass spectrometry studies of complexes, molecular sieving, nuclear magnetic resonance, pull down, tandem affinity purification, transmission electron microscopy, two hybrid, ubiquitin reconstruction, x ray scattering, x-ray crystallography association, direct interaction, physical, physical association 14580323 , 14985081 , 15383276 , 16009130 , 16291740 , 16461914 , 17332328 , 17612295 , 17620598 , 18087040 , 18414054 , 19011633 , 19339993 , 19667193 , 20004160 , 20080206 , 20159469 , 20235143 , 20364130 , 21084564 , 21178074 , 21231916 , 21522129 , 21988832 , 22522597 , 22653443 , 22819825 , 22972749 , 24037342 , 24374182 , 24722987 , 25402006 , 25603536 , 25609649 , 27462439 , 8035799 , (Europe PMC )0.98 BioGRID, IntAct, MINT TP53BP1 Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure, Co-localization, Protein-peptide, Reconstituted Complex, Two-hybrid physical 11877378 , 12110597 , 12351827 , 14978302 , 15364958 , 15611139 , 20307547 , 22084066 , 25651062 , 26022179 , 27546791 , 8016121 , (Europe PMC )NA BioGRID TP53BP2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, pull down, solid phase assay, two hybrid, x-ray crystallography association, direct interaction, physical, physical association 14985081 , 18275817 , 21513714 , 8016121 , 8668206 , 8875926 , (Europe PMC )0.83 BioGRID, IntAct, MINT TP53INP1 Affinity Capture-Western, Reconstituted Complex physical 11511362 , 12851404 , (Europe PMC )NA BioGRID TP53RK Reconstituted Complex physical 12659830 , (Europe PMC )NA BioGRID TP63 Affinity Capture-Western, Synthetic Rescue, anti bait coimmunoprecipitation genetic, physical, physical association 19345189 , 21511729 , 21741598 , 22575646 , 23687300 , 24554706 , 25417702 , (Europe PMC )0.59 BioGRID, IntAct TP73 Affinity Capture-Western, Two-hybrid physical 21508668 , 25417702 , 9802988 , 9891077 , (Europe PMC )NA BioGRID TPM1 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID TPM3 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID TPM4 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID TPT1 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, two hybrid, two hybrid pooling approach physical, physical association 21081126 , 22157679 , 22451927 , (Europe PMC )0.71 BioGRID, IntAct, MINT TRAF6 Affinity Capture-Western, Biochemical Activity physical 27818144 , (Europe PMC )NA BioGRID TRAPPC11 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID TRIAP1 Affinity Capture-RNA physical 15735003 , (Europe PMC )NA BioGRID TRIM24 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 19556538 , 22389628 , 24820418 , (Europe PMC )0.52 BioGRID, IntAct TRIM27 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 20972456 , (Europe PMC )NA BioGRID TRIM28 Affinity Capture-Western, Biochemical Activity, pull down association, physical 17056014 , 20858735 , 20864041 , (Europe PMC )0.35 BioGRID, IntAct TRIM32 Affinity Capture-Western physical 25146927 , (Europe PMC )NA BioGRID TRIM39 Affinity Capture-Western, Biochemical Activity physical 23213260 , (Europe PMC )NA BioGRID TRIM45 Affinity Capture-Western physical 28542145 , (Europe PMC )NA BioGRID TRIM59 Affinity Capture-Western physical 25046164 , (Europe PMC )NA BioGRID TRIM65 Affinity Capture-Western physical 27012201 , (Europe PMC )NA BioGRID TRIM8 Affinity Capture-Western physical 22262183 , (Europe PMC )NA BioGRID TRMT10C Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TRMT11 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID TRRAP Affinity Capture-Western, Co-localization, Reconstituted Complex physical 12138177 , 18250150 , (Europe PMC )NA BioGRID TSC22D1 Affinity Capture-Western, Two-hybrid physical 22870275 , (Europe PMC )NA BioGRID TSC22D3 Affinity Capture-Western, Co-localization, Reconstituted Complex physical 25168242 , (Europe PMC )NA BioGRID TSG101 Affinity Capture-Western physical 11172000 , (Europe PMC )NA BioGRID TSNAX Dosage Rescue genetic 20506231 , (Europe PMC )NA BioGRID TTC28 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID TTK Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 19332559 , (Europe PMC )NA BioGRID TTLL5 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID TUBA1A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TUBA1C Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID TUBA4A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TUBA8 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID TUBB Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT TUBB2A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT TUBB4B Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TUBG1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TWIST1 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, filter binding, pull down association, direct interaction, physical, physical association 18504427 , 22975381 , 25402006 , (Europe PMC )0.82 BioGRID, IntAct TXN Reconstituted Complex physical 19681600 , (Europe PMC )NA BioGRID TXNIP Affinity Capture-Western physical 23880345 , (Europe PMC )NA BioGRID TXNRD1 Affinity Capture-Western physical 15824742 , (Europe PMC )NA BioGRID UBB Affinity Capture-MS, anti bait coimmunoprecipitation physical, physical association 17936559 , 23443559 , (Europe PMC )0.40 BioGRID, IntAct UBC Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, physical, physical association 17139261 , 17159902 , 17170702 , 17268548 , 17290220 , 17568776 , 18309296 , 18388957 , 18566590 , 19098711 , 19536131 , 19619542 , 19798103 , 25168242 , 25471832 , (Europe PMC )0.96 BioGRID, IntAct, MINT UBD Affinity Capture-Western physical 21396347 , (Europe PMC )NA BioGRID UBE2A Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 12640129 , 22083959 , 24506068 , 28031328 , (Europe PMC )NA BioGRID UBE2B Affinity Capture-Western physical 22083959 , (Europe PMC )NA BioGRID UBE2I Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, pull down, two hybrid direct interaction, physical, physical association 10380882 , 10562557 , 10788439 , 10961991 , 11853669 , 12565873 , 15327968 , 16122737 , 16442531 , 17060459 , 17709345 , 18624398 , 19684601 , 21829513 , 22214662 , 23202365 , 23772552 , 8921390 , (Europe PMC )0.66 BioGRID, IntAct, MINT UBE2K Affinity Capture-Western, PCA physical 23933584 , (Europe PMC )NA BioGRID UBE2M Biochemical Activity physical 15242646 , (Europe PMC )NA BioGRID UBE2N Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 17000756 , 19651615 , (Europe PMC )NA BioGRID UBE2Q1 Affinity Capture-Western, Reconstituted Complex physical 25987028 , (Europe PMC )NA BioGRID UBE2V2 Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID UBE3A Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Reconstituted Complex physical 11027293 , 15001357 , 16493710 , 1661671 , 17131388 , 19364824 , 23040663 , 26789255 , 7708685 , 7724550 , 8090726 , 8380895 , 9450543 , 9688277 , (Europe PMC )NA BioGRID UBE4B Affinity Capture-Western, Biochemical Activity, Co-fractionation, Reconstituted Complex physical 21317885 , 24587254 , 26673821 , (Europe PMC )NA BioGRID UBQLN2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID UBR4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID UBR5 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 21383020 , 23443559 , 28689657 , (Europe PMC )NA BioGRID UCHL1 Affinity Capture-Western physical 18666234 , 20395212 , 29126443 , (Europe PMC )NA BioGRID UFD1 Two-hybrid physical 21900206 , (Europe PMC )NA BioGRID UHRF1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 26102039 , (Europe PMC )NA BioGRID UHRF2 Affinity Capture-Western, Far Western, Reconstituted Complex, anti tag coimmunoprecipitation, antibody array physical, physical association 21952639 , (Europe PMC )0.52 BioGRID, IntAct UIMC1 Affinity Capture-Western, Reconstituted Complex physical 19433585 , (Europe PMC )NA BioGRID UMPS Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID USH2A Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID USO1 Affinity Capture-Western physical 21147777 , (Europe PMC )NA BioGRID USP1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID USP10 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 20096447 , 24998844 , (Europe PMC )NA BioGRID USP11 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, anti tag coimmunoprecipitation physical, physical association 19615732 , 25471832 , (Europe PMC )0.40 BioGRID, IntAct USP15 Affinity Capture-Western physical 27893708 , (Europe PMC )NA BioGRID USP21 Biochemical Activity physical 27561390 , (Europe PMC )NA BioGRID USP24 Biochemical Activity physical 25578727 , (Europe PMC )NA BioGRID USP29 Affinity Capture-Western, anti tag coimmunoprecipitation physical, physical association 21285945 , (Europe PMC )0.40 BioGRID, IntAct, MINT USP3 Affinity Capture-Western, Biochemical Activity physical 28807825 , (Europe PMC )NA BioGRID USP39 Affinity Capture-MS, anti tag coimmunoprecipitation physical, physical association 19615732 , (Europe PMC )0.40 BioGRID, IntAct USP42 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation direct interaction, physical, physical association 22085928 , (Europe PMC )0.40, 0.54 BioGRID, IntAct, MINT USP7 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, classical fluorescence spectroscopy, coimmunoprecipitation, experimental interaction detection, isothermal titration calorimetry, molecular sieving, nuclear magnetic resonance, pull down, x-ray crystallography association, deubiquitination reaction, direct interaction, physical, physical association 11923872 , 14506283 , 15916963 , 16402859 , 16474402 , 16845383 , 17268548 , 17380154 , 17525743 , 20713061 , 20816748 , 21170034 , 21845734 , 22056774 , 22084066 , 22653443 , 23382381 , 23388826 , 24462112 , 25283148 , 26238070 , 26460617 , (Europe PMC )0.97 BioGRID, IntAct, MINT UTP14A Affinity Capture-Western, Reconstituted Complex physical 21078665 , (Europe PMC )NA BioGRID VASP Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID VAT1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID VCP Affinity Capture-MS, Affinity Capture-Western physical 23383273 , 23443559 , (Europe PMC )NA BioGRID VDR Affinity Capture-Western, anti bait coimmunoprecipitation, chromatin immunoprecipitation assay, fluorescence microscopy association, colocalization, physical, physical association 20227041 , (Europe PMC )0.54 BioGRID, IntAct VHL Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 16678111 , 21942715 , (Europe PMC )NA BioGRID VIM Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID VRK1 Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy, protein kinase assay, pull down colocalization, phosphorylation reaction, physical, physical association 10951572 , 11883897 , 15542844 , 24492002 , 29340707 , (Europe PMC )0.76 BioGRID, IntAct VRK2 Affinity Capture-Western, Biochemical Activity physical 16704422 , (Europe PMC )NA BioGRID WDR33 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct WDR48 Affinity Capture-MS, anti tag coimmunoprecipitation physical, physical association 19615732 , (Europe PMC )0.40 BioGRID, IntAct WDR5 Reconstituted Complex, anti tag coimmunoprecipitation, pull down association, physical 15960975 , 19433796 , 23870121 , (Europe PMC )0.69 BioGRID, IntAct WDR77 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID WDR82 Reconstituted Complex, anti tag coimmunoprecipitation association, physical 23870121 , (Europe PMC )0.35 BioGRID, IntAct WRN Affinity Capture-Western, Reconstituted Complex, enzyme linked immunosorbent assay, far western blotting, fluorescence microscopy colocalization, direct interaction, physical 11427532 , 12080066 , 15735006 , (Europe PMC )0.65 BioGRID, IntAct WT1 Affinity Capture-Western, Reconstituted Complex physical 8389468 , 9556563 , (Europe PMC )NA BioGRID WWOX Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation physical, physical association 11058590 , 15580310 , 16219768 , (Europe PMC )0.40 BioGRID, IntAct, MINT XAF1 Affinity Capture-Western, Phenotypic Enhancement, Reconstituted Complex genetic, physical 25313037 , (Europe PMC )NA BioGRID XPC Affinity Capture-Western physical 24258024 , (Europe PMC )NA BioGRID XRCC1 Affinity Capture-Western, anti bait coimmunoprecipitation association, physical 15044383 , (Europe PMC )0.35 BioGRID, IntAct XRCC6 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 15782130 , (Europe PMC )0.40 BioGRID, IntAct YBX1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 11175333 , 15136035 , 21344396 , 23443559 , 25144556 , (Europe PMC )NA BioGRID YTHDF1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID YWHAB Affinity Capture-Western physical 17898864 , (Europe PMC )NA BioGRID YWHAE Affinity Capture-MS, fluorescence polarization spectroscopy association, physical 18812399 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT YWHAZ Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical, physical association 16376338 , 22653443 , 9620776 , (Europe PMC )0.56 BioGRID, IntAct, MINT YY1 Affinity Capture-Western, Reconstituted Complex, pull down physical, physical association 15210108 , 15295102 , 18026119 , 22440256 , 25402006 , (Europe PMC )0.40 BioGRID, IntAct YY2 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct ZBTB16 Affinity Capture-Western physical 24821727 , (Europe PMC )NA BioGRID ZBTB17 Affinity Capture-Western physical 19901969 , 21804610 , (Europe PMC )NA BioGRID ZBTB2 Affinity Capture-Western, Reconstituted Complex physical 19380588 , (Europe PMC )NA BioGRID ZBTB33 Affinity Capture-Western, Co-localization physical 25288747 , 26183023 , (Europe PMC )NA BioGRID ZBTB7A Affinity Capture-Western, Reconstituted Complex physical 19244234 , 24857950 , (Europe PMC )NA BioGRID ZBTB8A Affinity Capture-Western, Reconstituted Complex physical 23329847 , (Europe PMC )NA BioGRID ZCCHC10 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct ZHX1 Two-hybrid physical 15383276 , (Europe PMC )NA BioGRID ZIC3 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct ZMIZ1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 17584785 , (Europe PMC )NA BioGRID ZMIZ2 Two-hybrid physical 17584785 , (Europe PMC )NA BioGRID ZMYND11 Affinity Capture-Western physical 17721438 , (Europe PMC )NA BioGRID ZNF148 Affinity Capture-Western, Reconstituted Complex physical 11416144 , (Europe PMC )NA BioGRID ZNF24 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct ZNF300 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ZNF302 Two-hybrid physical 18307271 , (Europe PMC )NA BioGRID ZNF420 Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down association, direct interaction, physical, physical association 19377469 , 20713054 , (Europe PMC )0.59 BioGRID, IntAct, MINT ZNF619 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ZNF668 Affinity Capture-Western physical 21852383 , (Europe PMC )NA BioGRID ZNF679 Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID ZNF763 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ZNF839 Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID ZNHIT1 Reconstituted Complex physical 17380123 , (Europe PMC )NA BioGRID ZWINT Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source AIPL1 Affinity Capture-MS, inference by socio-affinity scoring, tandem affinity purification association, physical, physical association 27173435 , (Europe PMC )0.51 BioGRID, IntAct ANK2 Reconstituted Complex, display technology physical, physical association 20195357 , (Europe PMC )0.40 BioGRID, IntAct ANXA3 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct ANXA7 Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT APOH Two-hybrid, two hybrid physical, physical association 18624398 , (Europe PMC )0.37 BioGRID, IntAct APPL1 Two-hybrid, two hybrid array physical, physical association 25814554 , (Europe PMC )0.37 BioGRID, IntAct APTX Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down association, physical 15044383 , (Europe PMC )0.46 BioGRID, IntAct AR Phenotypic Suppression, two hybrid genetic, physical association 11504717 , 19481544 , (Europe PMC )0.37 BioGRID, IntAct, MINT ARIH2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, pull down, two hybrid pooling approach association, direct interaction, physical, physical association 16169070 , 22819825 , (Europe PMC )0.69 BioGRID, IntAct, MINT ARL3 Synthetic Growth Defect, Two-hybrid, two hybrid pooling approach genetic, physical, physical association 16169070 , 23284306 , (Europe PMC )0.37 BioGRID, IntAct ARRB1 anti bait coimmunoprecipitation association, physical association 21857681 , (Europe PMC )0.50 IntAct ASH2L Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, physical 19433796 , 23870121 , (Europe PMC )0.64 BioGRID, IntAct ATAD3A anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT ATAD3B anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT ATF3 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid pooling approach physical, physical association 11792711 , 15933712 , 16169070 , 24554706 , (Europe PMC )0.37 BioGRID, IntAct ATG7 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down physical association 22499945 , (Europe PMC )0.40, 0.52 IntAct ATM Biochemical Activity, Co-localization, Phenotypic Enhancement, Protein-peptide, Reconstituted Complex, experimental interaction detection genetic, phosphorylation reaction, physical 10608806 , 10713094 , 10744722 , 10864201 , 11459832 , 14744854 , 15064416 , 15159397 , 15632067 , 15790808 , 17409407 , 19965871 , 21383020 , 23907539 , 24469230 , 25086746 , 27559048 , 9135004 , 9843217 , (Europe PMC )0.31 BioGRID, IntAct, MINT ATR Affinity Capture-Western, Biochemical Activity, Protein-peptide, Reconstituted Complex, Synthetic Growth Defect, protein kinase assay genetic, phosphorylation reaction, physical 10435622 , 10608806 , 11459832 , 15159397 , 15775976 , 16293623 , 20798688 , 23284306 , (Europe PMC )0.44 BioGRID, IntAct AURKB Affinity Capture-Western, protein kinase assay phosphorylation reaction, physical 20959462 , 29340707 , (Europe PMC )0.44 BioGRID, IntAct AXIN1 Affinity Capture-Western, Phenotypic Suppression, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation genetic, physical, physical association 21057547 , 23826318 , (Europe PMC )0.52 BioGRID, IntAct BAG2 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , 27807478 , (Europe PMC )0.35 BioGRID, IntAct, MINT BAG6 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT BANP Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation association, physical, physical association 19303885 , 20075864 , 22074660 , (Europe PMC )0.50 BioGRID, IntAct, MINT BARD1 Affinity Capture-MS, Affinity Capture-Western, Co-localization, anti bait coimmunoprecipitation physical, physical association 14636569 , 15782130 , 21742769 , 26022179 , (Europe PMC )0.40 BioGRID, IntAct BAX Affinity Capture-Western, Co-localization, Reconstituted Complex, proximity ligation assay physical, physical association 25115399 , 25241761 , (Europe PMC )0.40 BioGRID, IntAct BCL2 Affinity Capture-Western, anti bait coimmunoprecipitation association, physical, physical association 12667443 , 19521340 , 21597459 , 21624955 , (Europe PMC )0.56 BioGRID, IntAct, MINT BCL2L1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence polarization spectroscopy, isothermal titration calorimetry, nuclear magnetic resonance, pull down, surface plasmon resonance, two hybrid association, direct interaction, physical, physical association 12667443 , 14963330 , 16151013 , 20837658 , 21900206 , 24474649 , 24814347 , 25115399 , 26556313 , (Europe PMC )0.37, 0.88 BioGRID, IntAct, MINT BCL6 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct BCR Co-localization, Two-hybrid, proximity ligation assay, two hybrid pooling approach physical, physical association 16169070 , 25241761 , (Europe PMC )0.57 BioGRID, IntAct BHLHE40 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, imaging technique, pull down association, colocalization, physical, physical association 17347673 , 22723347 , (Europe PMC )0.73 BioGRID, IntAct, MINT BLM Affinity Capture-MS, Affinity Capture-Western, Co-localization, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation association, physical 11399766 , 11781842 , 12080066 , 15364958 , 22653443 , 24239288 , (Europe PMC )0.35 BioGRID, IntAct, MINT BMP1 Two-hybrid, two hybrid physical, physical association 18624398 , (Europe PMC )0.37 BioGRID, IntAct BMX anti bait coimmunoprecipitation physical association 16186805 , (Europe PMC )0.40 IntAct BRCA1 Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, coimmunoprecipitation, pull down direct interaction, physical, physical association 14636569 , 14710355 , 15571721 , 16677609 , 16969499 , 19509300 , 21742769 , 26140185 , 9482880 , 9582019 , 9926942 , (Europe PMC )0.54 BioGRID, IntAct, MINT BRCA2 Affinity Capture-MS, Affinity Capture-Western, Co-purification, classical fluorescence spectroscopy, isothermal titration calorimetry, nuclear magnetic resonance, pull down direct interaction, physical 14636569 , 20421506 , 9811893 , (Europe PMC )0.65 BioGRID, IntAct BRD7 Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy, pull down, two hybrid colocalization, physical, physical association 20228809 , 20660729 , (Europe PMC )0.73 BioGRID, IntAct BTBD2 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.51 BioGRID, IntAct BTRC Affinity Capture-Western, anti tag coimmunoprecipitation physical, physical association 19196987 , 21521785 , (Europe PMC )0.40 BioGRID, IntAct CABLES1 Affinity Capture-Western, coimmunoprecipitation physical, physical association 11706030 , 14637168 , (Europe PMC )0.40 BioGRID, IntAct CCAR2 anti tag coimmunoprecipitation physical interaction 18235501 , (Europe PMC )0.27 IntAct CCDC106 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, fluorescence microscopy, two hybrid pooling approach colocalization, physical, physical association 16169070 , 20159018 , (Europe PMC )0.61 BioGRID, IntAct, MINT CCDC8 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 22084066 , 22653443 , 23443559 , 24711643 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCL18 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct CCT2 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT3 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT4 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT5 Affinity Capture-MS, Two-hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach association, physical, physical association 16169070 , 22653443 , 23443559 , 25144556 , (Europe PMC )0.55 BioGRID, IntAct, MINT CCT6A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT7 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT8 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CDC42 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct CDK2 Biochemical Activity, Co-localization, proximity ligation assay physical, physical association 10884347 , 19556892 , 25241761 , (Europe PMC )0.40 BioGRID, IntAct CDKN1A Affinity Capture-Western, Co-localization, Two-hybrid, imaging technique, proximity ligation assay, two hybrid colocalization, physical, physical association 11896572 , 12897156 , 16616141 , 17371838 , 21900206 , 25241761 , (Europe PMC )0.65 BioGRID, IntAct, MINT CDKN2A anti tag coimmunoprecipitation, fluorescence microscopy association, colocalization 12740913 , 22653443 , (Europe PMC )0.49 IntAct, MINT CDKN2C Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct CEBPB anti bait coimmunoprecipitation, fluorescence microscopy, pull down colocalization, physical association 16227626 , (Europe PMC )0.56 IntAct CEBPZ Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down physical, physical association 12534345 , (Europe PMC )0.52 BioGRID, IntAct, MINT CEP120 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP128 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP135 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP152 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CHEK1 Affinity Capture-Western, Biochemical Activity, Co-localization, protein kinase assay phosphorylation reaction, physical 10673501 , 11896572 , 12756247 , 15364958 , 16511572 , (Europe PMC )0.44 BioGRID, IntAct, MINT CHEK2 Affinity Capture-Western, Biochemical Activity, experimental interaction detection, protein kinase assay phosphorylation reaction, physical 10673501 , 10710310 , 10724175 , 12810724 , 15862297 , 18833288 , (Europe PMC )0.65 BioGRID, IntAct, MINT CITED1 chromatin immunoprecipitation assay association 20227041 , (Europe PMC )0.35 IntAct CLK3 Affinity Capture-MS, tandem affinity purification association, physical 23602568 , (Europe PMC )0.35 BioGRID, IntAct COLGALT1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT COPS4 Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 22653443 , 24725084 , (Europe PMC )0.35 BioGRID, IntAct, MINT COX17 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct CREB1 Affinity Capture-Western, Co-localization, Reconstituted Complex, proximity ligation assay physical, physical association 10848610 , 16611888 , 21295542 , 25241761 , (Europe PMC )0.40 BioGRID, IntAct CREBBP Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-localization, FRET, Phenotypic Suppression, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, competition binding, proximity ligation assay, pull down association, genetic, physical, physical association 10196247 , 10551785 , 10823891 , 10848610 , 11782467 , 12154097 , 12426395 , 14722092 , 14759370 , 15632413 , 16537920 , 17434128 , 18485870 , 18753379 , 19166313 , 19234109 , 19357310 , 19805293 , 19880525 , 20962272 , 21390126 , 22084066 , 23908595 , 25314079 , 25451029 , 26976603 , 27618436 , 9194564 , 9288775 , (Europe PMC )0.91 BioGRID, IntAct, MINT CRK Two-hybrid, two hybrid array physical, physical association 25814554 , (Europe PMC )0.37 BioGRID, IntAct CSE1L anti bait coimmunoprecipitation, cross-linking study direct interaction, physical association 17719542 , (Europe PMC )0.54 IntAct CSNK1D Affinity Capture-Western, Biochemical Activity, Co-localization, proximity ligation assay physical, physical association 16870621 , 17101137 , 18246126 , 25241761 , (Europe PMC )0.40 BioGRID, IntAct CSNK1E Co-localization, proximity ligation assay physical, physical association 25241761 , (Europe PMC )0.40 BioGRID, IntAct CSNK2A1 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, protein kinase assay, proximity ligation assay phosphorylation reaction, physical, physical association 12628923 , 15358769 , 22975381 , 23443559 , 24725084 , 25241761 , (Europe PMC )0.61 BioGRID, IntAct CSNK2A2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT CUL7 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, molecular sieving, nuclear magnetic resonance, tandem affinity purification association, physical, physical association 16547496 , 16875676 , 17229476 , 17298945 , 17332328 , 17942889 , 22653443 , 23443559 , 24711643 , 25003318 , 25609649 , 26186194 , 28514442 , (Europe PMC )0.72 BioGRID, IntAct, MINT CUL9 Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid association, physical, physical association 12526791 , 16875676 , 17229476 , 17332328 , 17380154 , 18230339 , 21487039 , 22653443 , 23443559 , 25609649 , 26186194 , 28514442 , (Europe PMC )0.72 BioGRID, IntAct, MINT CXXC1 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, cross-linking study, pull down association, physical, physical association 23870121 , (Europe PMC )0.60 BioGRID, IntAct DAXX Affinity Capture-Western, Co-localization, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy, nuclear magnetic resonance, proximity ligation assay, two hybrid association, colocalization, direct interaction, physical, physical association 12482984 , 12954772 , 14557665 , 15339933 , 15364927 , 16845383 , 21134643 , 21482821 , 23038753 , 25241761 , (Europe PMC )0.44, 0.84 BioGRID, IntAct DDX17 anti bait coimmunoprecipitation, pull down physical association 15660129 , (Europe PMC )0.52 IntAct DDX5 Affinity Capture-MS, anti bait coimmunoprecipitation, pull down direct interaction, physical, physical association 15660129 , 20818423 , 23443559 , 24219989 , 25144556 , (Europe PMC )0.44, 0.54, 0.66 BioGRID, IntAct, MINT DLEU1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct DLST Affinity Capture-MS, cross-linking study association, physical 29128334 , (Europe PMC )0.35 BioGRID, IntAct DROSHA anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical association 19626115 , 24219989 , (Europe PMC )0.68 IntAct, MINT DUSP26 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, phosphatase assay, pull down dephosphorylation reaction, direct interaction, physical association 20562916 , (Europe PMC )0.65 IntAct DVL2 Two-hybrid, barcode fusion genetics two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid physical, physical association 16189514 , 16713569 , 27107012 , (Europe PMC )0.71 BioGRID, IntAct DYNC1I1 anti bait coimmunoprecipitation physical association 16616141 , (Europe PMC )0.40 IntAct, MINT EAF2 barcode fusion genetics two hybrid, validated two hybrid physical association 27107012 , (Europe PMC )0.49 IntAct EBI-16429055 two hybrid array, two hybrid prey pooling approach, validated two hybrid physical association 26871637 , (Europe PMC )0.56 IntAct EBI-1782980 electrophoretic mobility supershift assay physical association 18510931 , (Europe PMC )0.40 IntAct EBI-1799539 chromatin immunoprecipitation assay, electrophoretic mobility shift assay association, direct interaction 18485870 , (Europe PMC )0.52 IntAct EBI-1800051 electrophoretic mobility shift assay, electrophoretic mobility supershift assay association 18485870 , (Europe PMC )0.46 IntAct EBI-2624319 filter binding physical association 20227041 , (Europe PMC )0.40 IntAct EBI-4399559 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, comigration in sds page, pull down association, covalent binding, direct interaction, physical association 17470788 , 17592138 , 18172499 , 18359851 , 18413597 , 18695251 , 19196987 , 19556538 , 19805293 , 20173098 , 21857681 , 22056774 , 24667498 , (Europe PMC )0.97 IntAct EBI-714308 two hybrid pooling approach physical association 16169070 , (Europe PMC )0.37 IntAct EEF2 Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 12891704 , 22653443 , (Europe PMC )0.35 BioGRID, IntAct, MINT EGLN3 anti tag coimmunoprecipitation association 26972000 , (Europe PMC )0.35 IntAct EGR1 Affinity Capture-Western, Reconstituted Complex, cosedimentation colocalization, physical 11251186 , 14744935 , 15225550 , 21325822 , (Europe PMC )0.35 BioGRID, IntAct, MINT EIF2S2 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct ENSG00000019186 chromatin immunoprecipitation assay association 20227041 , (Europe PMC )0.35 IntAct ENSG00000024526 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000026508 chromatin immunoprecipitation assay, electrophoretic mobility supershift assay association, direct interaction 18614011 , (Europe PMC )0.52 IntAct ENSG00000048392 chromatin immunoprecipitation assay association 17719542 , (Europe PMC )0.35 IntAct ENSG00000072518 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000087088 chromatin immunoprecipitation assay association 17906639 , (Europe PMC )0.35 IntAct ENSG00000095203 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000100084 chromatin immunoprecipitation assay association 20227041 , (Europe PMC )0.35 IntAct ENSG00000105327 chromatin immunoprecipitation assay association 17719542 , (Europe PMC )0.35 IntAct ENSG00000105329 chromatin immunoprecipitation assay association 20227041 , (Europe PMC )0.35 IntAct ENSG00000105486 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000106018 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000111412 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000111605 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000112964 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000115129 chromatin immunoprecipitation assay association 17719542 , 18485870 , (Europe PMC )0.53 IntAct ENSG00000115163 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000119147 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000120471 chromatin immunoprecipitation assay association 17719542 , (Europe PMC )0.35 IntAct ENSG00000121152 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000124762 chromatin immunoprecipitation assay association 17719542 , 17906639 , 18614011 , 19249676 , 19410543 , 20228809 , 21317932 , 21423215 , 23870121 , (Europe PMC )0.90 IntAct ENSG00000126549 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000129195 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000131966 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000135679 chromatin immunoprecipitation assay association 17719542 , 18485870 , 20228809 , (Europe PMC )0.64 IntAct ENSG00000137752 electrophoretic mobility shift assay physical association 11278253 , (Europe PMC )0.40 IntAct ENSG00000138759 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000145194 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000145604 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000155090 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000156787 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000159055 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000163743 chromatin immunoprecipitation assay association 18485870 , (Europe PMC )0.35 IntAct ENSG00000167553 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000169679 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000175305 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000186260 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000187601 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000204963 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000205560 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000244005 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct EP300 Affinity Capture-Luminescence, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-fractionation, Co-localization, Phenotypic Suppression, Protein-peptide, Reconstituted Complex, acetylase assay, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, atomic force microscopy, classical fluorescence spectroscopy, coimmunoprecipitation, isothermal titration calorimetry, nuclear magnetic resonance, pull down, x ray scattering acetylation reaction, association, direct interaction, genetic, physical, physical association 10490106 , 10518217 , 10942770 , 11070080 , 11359905 , 11433299 , 11782467 , 11804596 , 11907332 , 12162806 , 12501250 , 12690203 , 12724314 , 14612423 , 14759370 , 15186775 , 15295102 , 15337767 , 15509808 , 15542844 , 15558054 , 15664194 , 15965232 , 16024799 , 16135789 , 16537920 , 16543236 , 16611888 , 16678111 , 16782091 , 16928824 , 16959611 , 17189186 , 17438265 , 17452980 , 17906639 , 17977830 , 18243116 , 18391200 , 18485870 , 18612383 , 19217391 , 19218448 , 19234109 , 19339993 , 19805293 , 20234175 , 21187340 , 21471221 , 22013068 , 22074660 , 22266186 , 22731250 , 23010591 , 23307557 , 23329847 , 23402884 , 23728348 , 23796514 , 23870121 , 23880760 , 24157709 , 24821727 , 25156994 , 25288747 , 25651062 , 25753752 , 25867071 , 26229107 , 26302407 , 26625199 , 27818144 , 9194564 , 9194565 , 9288740 , 9744860 , 9809062 , 9891054 , (Europe PMC )0.40, 0.97 BioGRID, IntAct, MINT ERH Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct ETS2 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down direct interaction, physical, physical association 18374905 , 26331536 , 26871468 , (Europe PMC )0.60 BioGRID, IntAct FAM173A Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct FBXO11 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, enzymatic study, pull down direct interaction, neddylation reaction, physical, physical association 17098746 , (Europe PMC )0.65 BioGRID, IntAct FBXW8 Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification association, physical 22653443 , 25609649 , (Europe PMC )0.53 BioGRID, IntAct, MINT FCAMR Two-hybrid, two hybrid physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct FOXA3 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXB1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXC1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXG1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXJ3 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXK1 tandem affinity purification association 25609649 , (Europe PMC )0.35 IntAct, MINT FOXK2 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXN1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXO3 anti tag coimmunoprecipitation, proximity ligation assay physical association 14976264 , 25241761 , (Europe PMC )0.59 IntAct FOXP1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXQ1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXS1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FXYD6 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct GADD45A Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT GFI1 anti tag coimmunoprecipitation physical association 23410974 , (Europe PMC )0.40 IntAct GLI1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT GNL3 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation physical, physical association 12464630 , 19033382 , (Europe PMC )0.40 BioGRID, IntAct GNL3L Affinity Capture-Western, anti tag coimmunoprecipitation physical, physical association 21132010 , (Europe PMC )0.40 BioGRID, IntAct GPX2 Two-hybrid, two hybrid physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct GRB2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT GSK3B Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, protein kinase assay, two hybrid phosphorylation reaction, physical, physical association 12048243 , 14744935 , 21900206 , (Europe PMC )0.66 BioGRID, IntAct, MINT GSTM4 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct GTF2H1 Co-crystal Structure, Far Western, Reconstituted Complex, pull down direct interaction, physical 16793543 , 18160537 , 18354501 , 7935417 , 8612585 , (Europe PMC )0.44 BioGRID, IntAct, MINT GUSBP1 two hybrid pooling approach physical association 16169070 , (Europe PMC )0.37 IntAct HDAC1 Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, proximity ligation assay association, physical, physical association 10521394 , 10777477 , 11099047 , 11313951 , 12426395 , 14976551 , 16107876 , 16697957 , 16959611 , 17827154 , 18765668 , 19011633 , 19303885 , 20075864 , 20633551 , 22266186 , 25241761 , 26539911 , (Europe PMC )0.73 BioGRID, IntAct, MINT HDAC2 Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 14976551 , 17805299 , 17827154 , 20190809 , 20388487 , 21344396 , 22493095 , (Europe PMC )0.35 BioGRID, IntAct HDAC3 anti tag coimmunoprecipitation association 16847267 , (Europe PMC )0.35 IntAct HDAC8 x-ray crystallography direct interaction 17721440 , (Europe PMC )0.44 IntAct, MINT HERC2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT HINFP Two-hybrid, two hybrid physical, physical association 21516116 , (Europe PMC )0.37 BioGRID, IntAct, MINT HIPK1 Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, two hybrid physical, physical association 12702766 , (Europe PMC )0.51 BioGRID, IntAct HIPK2 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down direct interaction, physical, physical association 11740489 , 11925430 , 15896780 , 16212962 , 17349959 , 21057547 , 25313037 , (Europe PMC )0.71 BioGRID, IntAct, MINT HIPK3 Affinity Capture-MS, Two-hybrid, tandem affinity purification physical, physical association 10961991 , 23602568 , (Europe PMC )0.40 BioGRID, IntAct HMGB1 Affinity Capture-Western, Reconstituted Complex, cross-linking study, far western blotting, isothermal titration calorimetry, molecular sieving, nuclear magnetic resonance direct interaction, physical, physical association 11106654 , 11748221 , 23063560 , 9472015 , (Europe PMC )0.74 BioGRID, IntAct HNRNPK Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down physical, physical association 21821029 , 23092970 , 25144556 , (Europe PMC )0.52, 0.59 BioGRID, IntAct, MINT HNRNPUL1 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, direct interaction, physical association 15907477 , 22653443 , (Europe PMC )0.70 IntAct, MINT HSP90AA1 Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, nuclear magnetic resonance direct interaction, physical 10557093 , 11297531 , 11507088 , 12427754 , 15001357 , 15358769 , 21268072 , 21460846 , 22939624 , 23443559 , (Europe PMC )0.44 BioGRID, IntAct HSP90AB1 Affinity Capture-MS, luminescence based mammalian interactome mapping physical, physical association 22939624 , 23443559 , (Europe PMC )0.40 BioGRID, IntAct HSPA1L Affinity Capture-MS, Co-localization, anti bait coimmunoprecipitation, proximity ligation assay physical, physical association 17184779 , 23443559 , 25241761 , (Europe PMC )0.59 BioGRID, IntAct, MINT HSPA5 anti bait coimmunoprecipitation physical association 17184779 , (Europe PMC )0.40 IntAct, MINT HSPA9 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, direct interaction, physical, physical association 11900485 , 17184779 , 20153329 , 22340593 , 22366412 , 22726440 , 23443559 , 25144556 , (Europe PMC )0.81 BioGRID, IntAct, MINT HSPB1 Affinity Capture-Western, Co-localization, Two-hybrid, anti bait coimmunoprecipitation, proximity ligation assay, two hybrid pooling approach physical, physical association 16169070 , 17184779 , 25241761 , (Europe PMC )0.69 BioGRID, IntAct, MINT HSPD1 anti bait coimmunoprecipitation association 22726440 , (Europe PMC )0.35 IntAct HTT Affinity Capture-Western, Reconstituted Complex, biochemical, pull down physical, physical association 10823891 , (Europe PMC )0.52 BioGRID, IntAct, MINT HUWE1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, pull down physical, physical association 15989956 , 22552282 , (Europe PMC )0.52 BioGRID, IntAct ICK Affinity Capture-MS, tandem affinity purification association, physical 23602568 , (Europe PMC )0.35 BioGRID, IntAct IFI16 Affinity Capture-Western, anti bait coimmunoprecipitation, classical fluorescence spectroscopy, confocal microscopy, pull down direct interaction, physical, physical association 11146555 , 21397192 , (Europe PMC )0.49, 0.72 BioGRID, IntAct IKBKB Biochemical Activity, anti bait coimmunoprecipitation, protein kinase assay phosphorylation reaction, physical, physical association 19196987 , 19883646 , (Europe PMC )0.61 BioGRID, IntAct, MINT ING2 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 16024799 , 16782091 , (Europe PMC )0.40 BioGRID, IntAct, MINT ING4 Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, coimmunoprecipitation physical, physical association 12750254 , 15251430 , 15882981 , 17954561 , 18775696 , 20053357 , 21177815 , 21454715 , 23967213 , (Europe PMC )0.40 BioGRID, IntAct, MINT IP6K2 anti bait coimmunoprecipitation, pull down direct interaction, physical association 21078964 , (Europe PMC )0.60 IntAct ITCH Affinity Capture-Western, anti bait coimmunoprecipitation association, physical 16908849 , 18559494 , 21474069 , (Europe PMC )0.35 BioGRID, IntAct JMJD6 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, hydroxylase assay, pull down association, direct interaction, hydroxylation reaction, physical association 24667498 , (Europe PMC )0.64 IntAct JMY anti bait coimmunoprecipitation physical association 10518217 , (Europe PMC )0.40 IntAct JUN anti bait coimmunoprecipitation association 25609649 , (Europe PMC )0.35 IntAct, MINT KAT2B anti bait coimmunoprecipitation association 16959611 , (Europe PMC )0.35 IntAct KAT5 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, anti tag coimmunoprecipitation, chromatin immunoprecipitation assay association, physical, physical association 15310756 , 16601686 , 17189186 , 17704809 , 18280244 , 18485870 , 23677994 , (Europe PMC )0.50 BioGRID, IntAct KAT8 Biochemical Activity, Reconstituted Complex, anti tag coimmunoprecipitation, pull down association, physical, physical association 15960975 , 16601686 , 17189187 , 19854137 , (Europe PMC )0.56 BioGRID, IntAct, MINT KDM1A Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, demethylase assay, pull down association, demethylation reaction, direct interaction, physical, physical association 17805299 , 18573881 , 22653443 , (Europe PMC )0.35, 0.66 BioGRID, IntAct, MINT KDM4A pull down association 23871696 , (Europe PMC )0.35 IntAct KHDRBS1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT KIAA0087 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct KMT2A Affinity Capture-MS, Reconstituted Complex, pull down association, physical 15960975 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct KMT2C anti tag coimmunoprecipitation association 19433796 , (Europe PMC )0.35 IntAct KMT2E Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 21423215 , (Europe PMC )0.52 BioGRID, IntAct KSR1 anti tag coimmunoprecipitation association 27086506 , (Europe PMC )0.35 IntAct KSR2 anti tag coimmunoprecipitation association 27086506 , (Europe PMC )0.35 IntAct LAMA4 Co-localization, Two-hybrid, proximity ligation assay, two hybrid pooling approach physical, physical association 16169070 , 25241761 , (Europe PMC )0.57 BioGRID, IntAct LMNA Affinity Capture-MS, pull down association, physical 25144556 , 29568061 , (Europe PMC )0.35 BioGRID, IntAct LRRK2 Affinity Capture-Western, Biochemical Activity, tandem affinity purification association, physical 24725412 , 26384650 , (Europe PMC )0.35 BioGRID, IntAct MAD2L1BP Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct MAGEA2 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, ubiquitinase assay association, direct interaction, physical, physical association, ubiquitination reaction 16847267 , 20864041 , 26468294 , (Europe PMC )0.73 BioGRID, IntAct MAGEB18 Two-hybrid, two hybrid array, two hybrid pooling approach physical, physical association 16189514 , 16713569 , (Europe PMC )0.55 BioGRID, IntAct MAGEC2 pull down, ubiquitinase assay association, physical association, ubiquitination reaction 20864041 , (Europe PMC )0.59 IntAct MAP1B anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy colocalization, physical association 18656471 , (Europe PMC )0.56 IntAct, MINT MAPK1 Affinity Capture-MS, Affinity Capture-Western, Co-localization, PCA, proximity ligation assay physical, physical association 10958792 , 21147777 , 21675959 , 23443559 , 25241761 , (Europe PMC )0.40 BioGRID, IntAct MAPK11 protein kinase assay phosphorylation reaction 17254968 , (Europe PMC )0.44 IntAct MAPK8 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation physical, physical association 11108663 , 12514174 , 15538975 , 15580310 , 18813780 , 19651615 , 9393873 , 9724739 , 9732264 , (Europe PMC )0.40 BioGRID, IntAct, MINT MAPKAPK5 Biochemical Activity, protein kinase assay phosphorylation reaction, physical 17254968 , (Europe PMC )0.44 BioGRID, IntAct MDM2 Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-RNA, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-fractionation, Co-localization, FRET, Far Western, PCA, Phenotypic Suppression, Protein-RNA, Protein-peptide, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, chromatin immunoprecipitation assay, classical fluorescence spectroscopy, cosedimentation in solution, enzyme linked immunosorbent assay, fluorescence polarization spectroscopy, isothermal titration calorimetry, molecular sieving, nuclear magnetic resonance, peptide array, proximity ligation assay, pull down, surface plasmon resonance, two hybrid, ubiquitinase assay, x-ray crystallography association, direct interaction, genetic, physical, physical association, ubiquitination reaction 10196247 , 10202144 , 10347217 , 10435614 , 10488081 , 10561590 , 10562557 , 10640350 , 10681559 , 10722742 , 10766163 , 10827196 , 10889512 , 10980696 , 11046142 , 11070080 , 11094089 , 11112690 , 11178989 , 11284721 , 11285227 , 11351297 , 11384992 , 11431470 , 11486026 , 11562347 , 11572869 , 11597128 , 11697899 , 11709713 , 11713287 , 11713288 , 11714701 , 11744695 , 11839577 , 11925449 , 12167711 , 12208736 , 12381304 , 12426395 , 12552135 , 12612087 , 12620407 , 12690203 , 12842086 , 12897156 , 12915590 , 12944468 , 14499615 , 14517261 , 14559824 , 14596917 , 14612427 , 14671306 , 14702041 , 14704432 , 14741215 , 15001357 , 15013777 , 15053879 , 15058298 , 15064742 , 15094782 , 15122315 , 15144954 , 15154850 , 15210108 , 15242646 , 15247280 , 15280377 , 15295102 , 15308643 , 15313915 , 15358376 , 15542844 , 15550400 , 15558054 , 15604276 , 15824742 , 15848166 , 15908921 , 15933712 , 15950904 , 16023600 , 16055726 , 16107876 , 1614537 , 16152627 , 16159876 , 16173922 , 16201274 , 16212962 , 16215989 , 16331255 , 16338390 , 16414131 , 16432196 , 16547496 , 16579792 , 16595680 , 16624812 , 16678796 , 16751805 , 16845383 , 16857591 , 16861890 , 16866370 , 16870621 , 16905769 , 16964247 , 17056014 , 17080083 , 17098746 , 17116689 , 17139261 , 17159902 , 17268548 , 17290220 , 17297477 , 17301054 , 17302414 , 17310983 , 17318220 , 17347673 , 17363365 , 17369817 , 17380154 , 17426254 , 17438265 , 17470788 , 17525743 , 17591690 , 17616658 , 17666403 , 17848574 , 17875722 , 17908790 , 17936559 , 17989425 , 18061646 , 18172499 , 18223694 , 18234963 , 18309296 , 18316739 , 18332869 , 18467333 , 18485870 , 18541670 , 18566590 , 18604177 , 18665269 , 18813780 , 18815136 , 18981217 , 19033382 , 19071110 , 19081178 , 19085961 , 19098711 , 19106616 , 19153082 , 19160491 , 19166840 , 19188367 , 19223463 , 19234109 , 19255450 , 19303885 , 19305137 , 19332559 , 19357310 , 19411066 , 19411846 , 19483087 , 19568783 , 19590512 , 19597489 , 19656744 , 19805293 , 19816404 , 19837670 , 19857530 , 19941302 , 20047188 , 20080206 , 20124408 , 20173098 , 20174603 , 20234175 , 20235143 , 20395212 , 20479273 , 20484049 , 20542919 , 20570896 , 20588255 , 20591429 , 20591651 , 20639885 , 20657550 , 20659896 , 20660730 , 20694676 , 20705607 , 20708156 , 20837658 , 20847049 , 20959462 , 20962272 , 21060154 , 21071676 , 21075307 , 21084285 , 21084564 , 21088494 , 21098709 , 21132010 , 21149449 , 21170087 , 21261729 , 21268072 , 21316347 , 21317885 , 21454483 , 21465263 , 21471462 , 21478269 , 21561866 , 21572037 , 21584881 , 21726810 , 21750659 , 21857681 , 21887275 , 21925390 , 21965653 , 21986495 , 21988832 , 22032989 , 22083959 , 22084066 , 22085928 , 22103682 , 22124327 , 22157679 , 22227409 , 22262183 , 22266850 , 22266868 , 22301280 , 22318540 , 22331460 , 22366412 , 22374672 , 22389628 , 22391559 , 22411991 , 22444248 , 22474335 , 22487680 , 22510990 , 22525275 , 22575647 , 22588298 , 22653443 , 22659184 , 22737255 , 22807444 , 22819825 , 22912717 , 22914926 , 22916255 , 22920093 , 22948151 , 22975381 , 23134341 , 23150668 , 23169665 , 23201157 , 23246961 , 23252402 , 23261415 , 23318437 , 23370271 , 23402884 , 23443559 , 23483203 , 23572512 , 23609977 , 23671280 , 23728348 , 23776060 , 23776465 , 23802716 , 23826318 , 23880345 , 23946421 , 24127580 , 24200963 , 24207125 , 24240685 , 24314634 , 24361594 , 24413661 , 24462112 , 24488098 , 24567357 , 24621507 , 24643130 , 24659749 , 24667498 , 24842904 , 24926618 , 24980433 , 24998844 , 25103245 , 25156994 , 25168242 , 25241761 , 25277184 , 25283148 , 25312347 , 25313037 , 25362358 , 25384516 , 25417702 , 25464845 , 25512388 , 25543083 , 25609649 , 25624478 , 25637791 , 25739118 , 25954860 , 26001071 , 26186194 , 26203195 , 26238070 , 26350565 , 26475964 , 26540344 , 26556313 , 26578655 , 26673821 , 26720344 , 26876197 , 26882543 , 26883110 , 26908445 , 27031960 , 27106262 , 27129163 , 27215386 , 27282385 , 27308622 , 27336364 , 27462439 , 27543608 , 27807478 , 27811966 , 27856536 , 27886165 , 27893708 , 28082682 , 28223335 , 28362432 , 28394340 , 28514442 , 28542145 , 28549433 , 28553961 , 28605833 , 7686617 , 7689721 , 8058315 , 8875929 , 9131587 , 9223638 , 9271120 , 9278461 , 9363941 , 9450543 , 9529249 , 9582019 , 9724739 , 9809062 , 9824166 , (Europe PMC )0.99 BioGRID, IntAct, MINT MDM4 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-localization, PCA, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, enzyme linked immunosorbent assay, fluorescence microscopy, fluorescence polarization spectroscopy, isothermal titration calorimetry, nuclear magnetic resonance, pull down, tandem affinity purification, ubiquitinase assay association, colocalization, direct interaction, physical, physical association, ubiquitination reaction 10075736 , 10608892 , 10827196 , 11223036 , 12370303 , 12393902 , 12874296 , 15604276 , 15916963 , 16024788 , 16227609 , 17080083 , 17301054 , 17875722 , 18316739 , 18485870 , 18677113 , 19075013 , 19153082 , 19255450 , 19305137 , 19432880 , 19521340 , 20174603 , 20515689 , 20705607 , 20724842 , 21075307 , 21088494 , 21925390 , 21965653 , 22266850 , 22374672 , 22807444 , 23028042 , 23671280 , 23946421 , 24127580 , 24445145 , 24659749 , 24667498 , 25464845 , 25609649 , 25825738 , 26148237 , 26186194 , 26876197 , 27114532 , 28487147 , 28514442 , 9226370 , (Europe PMC )0.96 BioGRID, IntAct, MINT MED1 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down physical, physical association 11118038 , 15848166 , 9444950 , (Europe PMC )0.52 BioGRID, IntAct, MINT MEN1 Reconstituted Complex, pull down association, physical 15960975 , (Europe PMC )0.35 BioGRID, IntAct MKRN1 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down direct interaction, physical, physical association 19536131 , (Europe PMC )0.60 BioGRID, IntAct, MINT MOV10 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT MPDZ anti tag coimmunoprecipitation association, physical association 22653443 , (Europe PMC )0.50 IntAct, MINT MPHOSPH6 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct MPP5 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT MRPS22 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT MT1A anti bait coimmunoprecipitation, pull down direct interaction, physical association 16442532 , (Europe PMC )0.54 IntAct, MINT MTOR Affinity Capture-Western, Synthetic Lethality, anti bait coimmunoprecipitation association, genetic, physical 19619545 , 27438146 , (Europe PMC )0.35 BioGRID, IntAct, MINT MYC Affinity Capture-MS, tandem affinity purification association, physical 21150319 , (Europe PMC )0.35 BioGRID, IntAct NABP1 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct NAP1L1 pull down direct interaction 14966293 , (Europe PMC )0.44 IntAct, MINT NCL Affinity Capture-Western, Far Western, Reconstituted Complex, far western blotting, pull down direct interaction, physical 12138209 , 22103682 , 26238070 , (Europe PMC )0.56 BioGRID, IntAct, MINT NCOA2 Reconstituted Complex, display technology physical, physical association 20195357 , (Europe PMC )0.40 BioGRID, IntAct NCOA6 anti tag coimmunoprecipitation association 19433796 , (Europe PMC )0.35 IntAct NCOR2 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, competition binding, pull down direct interaction, physical association 24449765 , (Europe PMC )0.65 IntAct, MINT NEDD8 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT NEIL3 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct NEURL4 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT NFATC1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT NFYA Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, imaging technique association, colocalization, physical, physical association 15831478 , 16959611 , 23908595 , (Europe PMC )0.54 BioGRID, IntAct NFYB Affinity Capture-Western, anti bait coimmunoprecipitation association, physical, physical association 15831478 , 16959611 , 23734815 , (Europe PMC )0.56 BioGRID, IntAct NIN Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct NINL Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct NMT1 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 16530191 , (Europe PMC )0.40 BioGRID, IntAct, MINT NMT2 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 16530191 , (Europe PMC )0.40 BioGRID, IntAct, MINT NOC2L Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, tandem affinity purification association, direct interaction, physical, physical association 16322561 , 20959462 , (Europe PMC )0.63 BioGRID, IntAct NOL3 anti bait coimmunoprecipitation direct interaction, physical association 18087040 , (Europe PMC )0.54 IntAct NPAS3 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT NPM1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, coimmunoprecipitation, cross-linking study, surface plasmon resonance association, direct interaction, physical, physical association 12080348 , 15144954 , 15964625 , 16376884 , 16740634 , 23443559 , (Europe PMC )0.35, 0.56, 0.68 BioGRID, IntAct, MINT NR0B2 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 22575647 , 22737255 , (Europe PMC )0.52 BioGRID, IntAct, MINT NR4A1 Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down, two hybrid array physical, physical association 17139261 , (Europe PMC )0.58 BioGRID, IntAct, MINT NRDC anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical association 22653443 , (Europe PMC )0.58 IntAct, MINT NT5C2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT NUAK1 anti bait coimmunoprecipitation, chromatin immunoprecipitation assay, protein kinase assay association, phosphorylation reaction, physical association 21317932 , (Europe PMC )0.59 IntAct NUDT16L1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT NUMB anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, direct interaction 18172499 , (Europe PMC )0.63 IntAct OBSL1 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, tandem affinity purification association, physical 22653443 , 23443559 , 24711643 , 25609649 , (Europe PMC )0.53 BioGRID, IntAct, MINT OFD1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct OLA1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT OTUB1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, direct interaction, physical, physical association 22124327 , 24403071 , 27561390 , (Europe PMC )0.63 BioGRID, IntAct, MINT OTUD5 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation physical, physical association 19615732 , 24143256 , 25499082 , (Europe PMC )0.40 BioGRID, IntAct PADI1 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct PAFAH1B3 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct PAGR1 pull down physical association 19039327 , (Europe PMC )0.40 IntAct, MINT PARD3 anti tag coimmunoprecipitation association, physical association 22653443 , (Europe PMC )0.50 IntAct, MINT PARP1 Affinity Capture-Western, Far Western, Reconstituted Complex, anti bait coimmunoprecipitation, coimmunoprecipitation, pull down association, direct interaction, physical, physical association 12898523 , 14627987 , 15044383 , 9312059 , 9565608 , (Europe PMC )0.75 BioGRID, IntAct, MINT PAXIP1 anti tag coimmunoprecipitation association 19433796 , (Europe PMC )0.35 IntAct PBK anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, two hybrid physical association 17482142 , 20622899 , (Europe PMC )0.71 IntAct PCDHA4 two hybrid pooling approach physical association 16169070 , (Europe PMC )0.37 IntAct PDHA1 Affinity Capture-MS, cross-linking study association, physical 29128334 , (Europe PMC )0.35 BioGRID, IntAct PES1 tandem affinity purification association 25609649 , (Europe PMC )0.35 IntAct, MINT PHB Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy, fluorescence microscopy colocalization, physical, physical association 14500729 , 16319068 , 20134482 , 24380853 , (Europe PMC )0.62 BioGRID, IntAct, MINT PHC3 tandem affinity purification association 27705803 , (Europe PMC )0.35 IntAct PHF1 Affinity Capture-MS, Affinity Capture-Western, tandem affinity purification association, physical 18385154 , 23150668 , 27705803 , (Europe PMC )0.35 BioGRID, IntAct PIAS1 Biochemical Activity, Co-localization, Reconstituted Complex, Two-hybrid, proximity ligation assay, pull down direct interaction, physical, physical association 10380882 , 11583632 , 11867732 , 15133049 , 20805487 , 25241761 , (Europe PMC )0.61 BioGRID, IntAct PIAS2 Biochemical Activity, Co-localization, Reconstituted Complex, Two-hybrid, proximity ligation assay, two hybrid physical, physical association 11867732 , 18624398 , 19339993 , 25241761 , (Europe PMC )0.57 BioGRID, IntAct PIAS4 Two-hybrid, anti bait coimmunoprecipitation, two hybrid physical, physical association 11388671 , 15383276 , (Europe PMC )0.51 BioGRID, IntAct PIN1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, chromatin immunoprecipitation assay, coimmunoprecipitation, pull down, two hybrid association, physical, physical association 12388558 , 12397362 , 17906639 , 21741598 , 21900206 , (Europe PMC )0.85 BioGRID, IntAct, MINT PLCG2 Two-hybrid, two hybrid array, validated two hybrid physical, physical association 25814554 , (Europe PMC )0.49 BioGRID, IntAct PLK1 Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay, two hybrid association, phosphorylation reaction, physical, physical association 16753148 , 19833129 , 22653443 , (Europe PMC )0.74 BioGRID, IntAct, MINT PLOD3 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT PML Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy, imaging technique, proximity ligation assay association, colocalization, physical, physical association 11025664 , 11080164 , 12006491 , 12915590 , 14976551 , 15375079 , 16007146 , 20972456 , 21057547 , 22869143 , 25241761 , (Europe PMC )0.49, 0.72 BioGRID, IntAct PNP Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct POLRMT Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT PPA1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct PPIF anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down direct interaction, physical association 22726440 , (Europe PMC )0.64 IntAct PPM1G anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT PPP1CA Two-hybrid, two hybrid physical, physical association 15231748 , (Europe PMC )0.37 BioGRID, IntAct, MINT PPP1CC Affinity Capture-Western, anti bait coimmunoprecipitation, antibody array physical, physical association 17274640 , (Europe PMC )0.52 BioGRID, IntAct PPP1R13B Affinity Capture-Western, Synthetic Growth Defect, anti bait coimmunoprecipitation association, genetic, physical 21513714 , 23284306 , (Europe PMC )0.35 BioGRID, IntAct, MINT PPP1R13L Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, fluorescence microscopy, pull down, solid phase assay association, colocalization, direct interaction, physical, physical association 12524540 , 17906639 , 18275817 , 20840860 , 21513714 , 23443559 , 23623661 , (Europe PMC )0.81 BioGRID, IntAct, MINT PPP2R1A Affinity Capture-MS, Co-localization, anti bait coimmunoprecipitation, proximity ligation assay, pull down physical, physical association 12665691 , 17245430 , 25241761 , (Europe PMC )0.66 BioGRID, IntAct, MINT PPP2R2A anti bait coimmunoprecipitation physical association 17245430 , (Europe PMC )0.40 IntAct, MINT PPP2R5C Co-localization, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, proximity ligation assay association, physical, physical association 17245430 , 21460856 , 25241761 , (Europe PMC )0.35, 0.69 BioGRID, IntAct, MINT PRKAB2 barcode fusion genetics two hybrid, validated two hybrid physical association 27107012 , (Europe PMC )0.49 IntAct PRKCD Affinity Capture-Western, anti bait coimmunoprecipitation, protein kinase assay, pull down phosphorylation reaction, physical, physical association 16314418 , 16377624 , (Europe PMC )0.60 BioGRID, IntAct PSMC1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT PSMD11 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct PSMD2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT PSMD5 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT PSME3 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, physical, physical association 18309296 , 21084564 , (Europe PMC )0.58 BioGRID, IntAct, MINT PTBP3 anti bait coimmunoprecipitation association 22575643 , (Europe PMC )0.35 IntAct, MINT PTK2 Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy, proximity ligation assay, pull down colocalization, direct interaction, physical, physical association 15855171 , 18206965 , 19857493 , 25241761 , (Europe PMC )0.76 BioGRID, IntAct, MINT PYCR3 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT RAB4A Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct RABGAP1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT RAD51 Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, coimmunoprecipitation physical, physical association 14636569 , 15064730 , 16983346 , 26140185 , 8617246 , 9380510 , (Europe PMC )0.40 BioGRID, IntAct RANBP9 Two-hybrid, anti tag coimmunoprecipitation association, physical 18307271 , 22653443 , (Europe PMC )0.35 BioGRID, IntAct, MINT RAP1B Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT RASGRF1 anti bait coimmunoprecipitation physical association 16753148 , (Europe PMC )0.40 IntAct, MINT RB1 Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 20871633 , 8083962 , (Europe PMC )0.35 BioGRID, IntAct RB1CC1 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 20614030 , 21775823 , (Europe PMC )0.40 BioGRID, IntAct RBBP5 Affinity Capture-Western, Reconstituted Complex, Synthetic Growth Defect, anti tag coimmunoprecipitation, pull down association, genetic, physical 15960975 , 19433796 , 23284306 , 23870121 , (Europe PMC )0.69 BioGRID, IntAct RBPJ Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, microscale thermophoresis direct interaction, physical, physical association 26302407 , (Europe PMC )0.65 BioGRID, IntAct RBX1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT RCC1 Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT RCHY1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, imaging technique, nuclear magnetic resonance, pull down, two hybrid colocalization, direct interaction, physical, physical association 12654245 , 17568776 , 19043414 , 19483087 , 20452352 , 21084285 , 21791603 , 21988832 , 24367557 , 25116336 , (Europe PMC )0.85 BioGRID, IntAct, MINT RFWD2 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, experimental interaction detection, pull down association, direct interaction, physical association, ubiquitination reaction 15103385 , 21625211 , (Europe PMC )0.72 IntAct, MINT RFWD3 anti bait coimmunoprecipitation, pull down association, direct interaction, physical association 20173098 , (Europe PMC )0.62 IntAct RING1 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy, pull down, ubiquitinase assay colocalization, physical, physical association, ubiquitination reaction 22907436 , 29187402 , (Europe PMC )0.65 BioGRID, IntAct RNASEL Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT RNF20 Affinity Capture-Western, Reconstituted Complex, pull down association, physical 16337599 , 19410543 , (Europe PMC )0.35 BioGRID, IntAct RNF40 pull down association 19410543 , (Europe PMC )0.35 IntAct RPA1 Affinity Capture-Western, Reconstituted Complex, enzyme linked immunosorbent assay physical, physical association 11751427 , 15489903 , 15735006 , 23267009 , (Europe PMC )0.40 BioGRID, IntAct RPA2 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT RPGRIP1L Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct RPL5 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 15308643 , 22653443 , 23169665 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT RPS19BP1 anti bait coimmunoprecipitation association 17964266 , (Europe PMC )0.35 IntAct RPS27A Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 21561866 , 22653443 , (Europe PMC )0.35 BioGRID, IntAct, MINT RPS3 FRET, fluorescent resonance energy transfer, proximity ligation assay, pull down association, direct interaction, physical, physical association 19656744 , (Europe PMC )0.63 BioGRID, IntAct RPS7 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 17310983 , 19683495 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct RRM2B Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical, physical association 12615712 , 19015526 , (Europe PMC )0.35, 0.40 BioGRID, IntAct RYBP Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical, physical association 19098711 , (Europe PMC )0.50 BioGRID, IntAct, MINT S100A1 molecular sieving direct interaction 20591429 , (Europe PMC )0.44 IntAct, MINT S100A2 molecular sieving direct interaction 20591429 , (Europe PMC )0.44 IntAct, MINT S100A4 Affinity Capture-Western, Reconstituted Complex, confocal microscopy, cross-linking study, far western blotting, fluorescence polarization spectroscopy, molecular sieving, proximity ligation assay colocalization, direct interaction, physical, physical association 11527429 , 19740107 , 20070253 , 20591429 , 23752197 , (Europe PMC )0.79 BioGRID, IntAct, MINT S100A6 Reconstituted Complex, molecular sieving direct interaction, physical 20591429 , 23796514 , (Europe PMC )0.44 BioGRID, IntAct, MINT S100A8 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct S100B Affinity Capture-Western, molecular sieving direct interaction, physical 15178678 , 20591429 , (Europe PMC )0.44 BioGRID, IntAct, MINT SAE1 anti tag coimmunoprecipitation covalent binding 15327968 , (Europe PMC )0.44 IntAct, MINT SAFB Affinity Capture-Western, anti bait coimmunoprecipitation, fluorescence microscopy, pull down colocalization, physical, physical association 21130767 , (Europe PMC )0.56 BioGRID, IntAct, MINT SAFB2 Affinity Capture-Western, pull down physical, physical association 21130767 , (Europe PMC )0.40 BioGRID, IntAct, MINT SARS2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT SAT1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct SCAMP1 Two-hybrid, two hybrid array physical, physical association 16713569 , (Europe PMC )0.37 BioGRID, IntAct SERPINB9 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct SETD1A Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, physical 23870121 , (Europe PMC )0.53 BioGRID, IntAct SETD7 Biochemical Activity, Co-crystal Structure, Two-hybrid, competition binding, enzymatic study, methyltransferase assay, methyltransferase radiometric assay, pull down, two hybrid, x-ray crystallography direct interaction, methylation reaction, physical, physical association 15525938 , 16415881 , 17108971 , 17805299 , 21245319 , 21988832 , (Europe PMC )0.92 BioGRID, IntAct SFN Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, isothermal titration calorimetry, x-ray crystallography association, direct interaction, physical 11896572 , 14517281 , 17546054 , 20206173 , 21625211 , (Europe PMC )0.67 BioGRID, IntAct, MINT SIN3A anti bait coimmunoprecipitation, pull down physical association 10823891 , 11359905 , (Europe PMC )0.59 IntAct, MINT SIRT1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, acetylase assay, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, deacetylase assay, pull down association, deacetylation reaction, direct interaction, physical, physical association, physical interaction 11672523 , 12006491 , 15205477 , 17964266 , 18235501 , 18235502 , 18753379 , 21149449 , 21245319 , 22389628 , 22689577 , 22735644 , (Europe PMC )0.96 BioGRID, IntAct SKP1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT SMAD2 Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, proximity ligation assay physical, physical association 12732139 , 19345189 , 19580641 , 23687300 , 25241761 , 25670079 , (Europe PMC )0.70 BioGRID, IntAct SMARCA4 Affinity Capture-Western, Co-fractionation, Reconstituted Complex, anti bait coimmunoprecipitation association, physical 11950834 , 17666433 , 18303029 , 21900401 , (Europe PMC )0.35 BioGRID, IntAct SMARCA5 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT SMARCAL1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT SMARCC1 Affinity Capture-Western, Co-fractionation, anti bait coimmunoprecipitation association, physical 11950834 , 18303029 , (Europe PMC )0.35 BioGRID, IntAct SMG5 Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification association, physical 22653443 , 25609649 , (Europe PMC )0.53 BioGRID, IntAct, MINT SMG7 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 22653443 , 27462439 , (Europe PMC )0.35 BioGRID, IntAct, MINT SMN1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid physical, physical association 11704667 , 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT SMYD2 Affinity Capture-Western, Biochemical Activity, isothermal titration calorimetry, methyltransferase assay, methyltransferase radiometric assay, tandem affinity purification, x-ray crystallography adp ribosylation reaction, direct interaction, methylation reaction, physical 17108971 , 17805299 , 18065756 , 21782458 , 25609649 , (Europe PMC )0.81 BioGRID, IntAct, MINT SNAI1 Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 20385133 , 28067227 , (Europe PMC )0.52 BioGRID, IntAct, MINT SNRPN Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct SOX4 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down physical, physical association 19234109 , (Europe PMC )0.59 BioGRID, IntAct SP1 Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation physical, physical association 12665570 , 15574328 , 15674334 , 15710382 , 16740634 , 18765668 , 19846904 , 20570896 , 21325822 , 21831840 , 23650532 , 8463313 , 9492043 , 9685344 , (Europe PMC )0.59 BioGRID, IntAct, MINT SPICE1 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct SREBF1 cross-linking study physical association 22265415 , (Europe PMC )0.40 IntAct SREBF2 anti bait coimmunoprecipitation, cross-linking study physical association 22265415 , (Europe PMC )0.52 IntAct SRPK1 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down physical association 21130767 , (Europe PMC )0.59 IntAct, MINT SSX2IP Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct STK11 Affinity Capture-Western, chromatin immunoprecipitation assay association, physical 11430832 , 21317932 , (Europe PMC )0.35 BioGRID, IntAct STK4 Co-localization, proximity ligation assay physical, physical association 25241761 , (Europe PMC )0.40 BioGRID, IntAct STX5 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct SULT1E1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct SUMO1 Two-hybrid, comigration in sds page, pull down covalent binding, direct interaction, physical, physical association 10961991 , 16732283 , 19684601 , 20534433 , (Europe PMC )0.72 BioGRID, IntAct SUMO2 pull down association 20534433 , (Europe PMC )0.35 IntAct SYVN1 Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, imaging technique, pull down colocalization, physical, physical association 17170702 , 21903092 , 26254280 , (Europe PMC )0.61 BioGRID, IntAct, MINT TBP Affinity Capture-Western, Reconstituted Complex, far western blotting, pull down direct interaction, physical, physical association 10359315 , 11313951 , 12379483 , 1465435 , 7799929 , 8083962 , 9349482 , (Europe PMC )0.40, 0.44 BioGRID, IntAct, MINT TCF4 Affinity Capture-MS, Reconstituted Complex, pull down, tandem affinity purification association, physical, physical association 25402006 , 25609649 , (Europe PMC )0.56 BioGRID, IntAct, MINT TCP1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT TDRD12 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT THAP8 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct TK1 Two-hybrid, two hybrid, two hybrid pooling approach physical, physical association 16169070 , 21900206 , (Europe PMC )0.55 BioGRID, IntAct, MINT TMSB4X two hybrid pooling approach physical association 16169070 , (Europe PMC )0.37 IntAct TOE1 anti bait coimmunoprecipitation, biophysical, pull down association, direct interaction 19508870 , (Europe PMC )0.58 IntAct, MINT TOP1MT Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct TOP3A anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TOPORS Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation physical, physical association 11842245 , 15247280 , 16122737 , 17290218 , 17803295 , (Europe PMC )0.40 BioGRID, IntAct, MINT TP53 Affinity Capture-Western, Co-crystal Structure, Co-fractionation, Co-purification, FRET, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, comigration in gel electrophoresis, comigration in non denaturing gel electrophoresis, cosedimentation in solution, cross-linking study, electron microscopy, mass spectrometry studies of complexes, molecular sieving, nuclear magnetic resonance, pull down, tandem affinity purification, transmission electron microscopy, two hybrid, ubiquitin reconstruction, x ray scattering, x-ray crystallography association, direct interaction, physical, physical association 14580323 , 14985081 , 15383276 , 16009130 , 16291740 , 16461914 , 17332328 , 17612295 , 17620598 , 18087040 , 18414054 , 19011633 , 19339993 , 19667193 , 20004160 , 20080206 , 20159469 , 20235143 , 20364130 , 21084564 , 21178074 , 21231916 , 21522129 , 21988832 , 22522597 , 22653443 , 22819825 , 22972749 , 24037342 , 24374182 , 24722987 , 25402006 , 25603536 , 25609649 , 27462439 , 8035799 , (Europe PMC )0.98 BioGRID, IntAct, MINT TP53BP1 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, classical fluorescence spectroscopy, nuclear magnetic resonance, peptide array, pull down, two hybrid, x-ray crystallography association, direct interaction, physical association 11877378 , 14985081 , 17805299 , 19433796 , 22653443 , 25579814 , 25651062 , 25837623 , (Europe PMC )0.83, 0.88 IntAct, MINT TP53BP2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, pull down, solid phase assay, two hybrid, x-ray crystallography association, direct interaction, physical, physical association 14985081 , 18275817 , 21513714 , 8016121 , 8668206 , 8875926 , (Europe PMC )0.83 BioGRID, IntAct, MINT TP63 Affinity Capture-Western, Synthetic Rescue, anti bait coimmunoprecipitation genetic, physical, physical association 19345189 , 21511729 , 21741598 , 22575646 , 23687300 , 24554706 , 25417702 , (Europe PMC )0.59 BioGRID, IntAct TPT1 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, two hybrid, two hybrid pooling approach physical, physical association 21081126 , 22157679 , 22451927 , (Europe PMC )0.71 BioGRID, IntAct, MINT TRAF1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TRIM24 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 19556538 , 22389628 , 24820418 , (Europe PMC )0.52 BioGRID, IntAct TRIM28 Affinity Capture-Western, Biochemical Activity, pull down association, physical 17056014 , 20858735 , 20864041 , (Europe PMC )0.35 BioGRID, IntAct TSPAN10 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TSPYL4 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TUBB Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT TUBB2A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT TUBB3 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TWIST1 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, filter binding, pull down association, direct interaction, physical, physical association 18504427 , 22975381 , 25402006 , (Europe PMC )0.82 BioGRID, IntAct TWIST2 pull down physical association 22975381 , (Europe PMC )0.40 IntAct TWNK anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT UBA1 ubiquitinase assay ubiquitination reaction 29187402 , (Europe PMC )0.44 IntAct UBB Affinity Capture-MS, anti bait coimmunoprecipitation physical, physical association 17936559 , 23443559 , (Europe PMC )0.40 BioGRID, IntAct UBC Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, physical, physical association 17139261 , 17159902 , 17170702 , 17268548 , 17290220 , 17568776 , 18309296 , 18388957 , 18566590 , 19098711 , 19536131 , 19619542 , 19798103 , 25168242 , 25471832 , (Europe PMC )0.96 BioGRID, IntAct, MINT UBE2E1 ubiquitinase assay ubiquitination reaction 29187402 , (Europe PMC )0.44 IntAct UBE2I Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, pull down, two hybrid direct interaction, physical, physical association 10380882 , 10562557 , 10788439 , 10961991 , 11853669 , 12565873 , 15327968 , 16122737 , 16442531 , 17060459 , 17709345 , 18624398 , 19684601 , 21829513 , 22214662 , 23202365 , 23772552 , 8921390 , (Europe PMC )0.66 BioGRID, IntAct, MINT UBE3A molecular sieving, pull down, surface plasmon resonance, two hybrid array, two hybrid prey pooling approach, x-ray crystallography association, direct interaction, physical association 12620801 , 16493710 , 26789255 , 29426014 , (Europe PMC )0.49, 0.77 IntAct, MINT UFD1 two hybrid physical association 21900206 , (Europe PMC )0.37 IntAct, MINT UHRF2 Affinity Capture-Western, Far Western, Reconstituted Complex, anti tag coimmunoprecipitation, antibody array physical, physical association 21952639 , (Europe PMC )0.52 BioGRID, IntAct USP11 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, anti tag coimmunoprecipitation physical, physical association 19615732 , 25471832 , (Europe PMC )0.40 BioGRID, IntAct USP28 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT USP29 Affinity Capture-Western, anti tag coimmunoprecipitation physical, physical association 21285945 , (Europe PMC )0.40 BioGRID, IntAct, MINT USP39 Affinity Capture-MS, anti tag coimmunoprecipitation physical, physical association 19615732 , (Europe PMC )0.40 BioGRID, IntAct USP42 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation direct interaction, physical, physical association 22085928 , (Europe PMC )0.40, 0.54 BioGRID, IntAct, MINT USP7 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, classical fluorescence spectroscopy, coimmunoprecipitation, experimental interaction detection, isothermal titration calorimetry, molecular sieving, nuclear magnetic resonance, pull down, x-ray crystallography association, deubiquitination reaction, direct interaction, physical, physical association 11923872 , 14506283 , 15916963 , 16402859 , 16474402 , 16845383 , 17268548 , 17380154 , 17525743 , 20713061 , 20816748 , 21170034 , 21845734 , 22056774 , 22084066 , 22653443 , 23382381 , 23388826 , 24462112 , 25283148 , 26238070 , 26460617 , (Europe PMC )0.97 BioGRID, IntAct, MINT VDR Affinity Capture-Western, anti bait coimmunoprecipitation, chromatin immunoprecipitation assay, fluorescence microscopy association, colocalization, physical, physical association 20227041 , (Europe PMC )0.54 BioGRID, IntAct VRK1 Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy, protein kinase assay, pull down colocalization, phosphorylation reaction, physical, physical association 10951572 , 11883897 , 15542844 , 24492002 , 29340707 , (Europe PMC )0.76 BioGRID, IntAct WDR33 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct WDR48 Affinity Capture-MS, anti tag coimmunoprecipitation physical, physical association 19615732 , (Europe PMC )0.40 BioGRID, IntAct WDR5 Reconstituted Complex, anti tag coimmunoprecipitation, pull down association, physical 15960975 , 19433796 , 23870121 , (Europe PMC )0.69 BioGRID, IntAct WDR82 Reconstituted Complex, anti tag coimmunoprecipitation association, physical 23870121 , (Europe PMC )0.35 BioGRID, IntAct WRN Affinity Capture-Western, Reconstituted Complex, enzyme linked immunosorbent assay, far western blotting, fluorescence microscopy colocalization, direct interaction, physical 11427532 , 12080066 , 15735006 , (Europe PMC )0.65 BioGRID, IntAct WWOX Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation physical, physical association 11058590 , 15580310 , 16219768 , (Europe PMC )0.40 BioGRID, IntAct, MINT XPO1 anti bait coimmunoprecipitation physical association 17268548 , 18952844 , (Europe PMC )0.59 IntAct, MINT XRCC1 Affinity Capture-Western, anti bait coimmunoprecipitation association, physical 15044383 , (Europe PMC )0.35 BioGRID, IntAct XRCC6 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 15782130 , (Europe PMC )0.40 BioGRID, IntAct YTHDC2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT YWHAE Affinity Capture-MS, fluorescence polarization spectroscopy association, physical 18812399 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT YWHAG anti tag coimmunoprecipitation, coimmunoprecipitation, fluorescence polarization spectroscopy association 18812399 , 19933256 , 22653443 , (Europe PMC )0.64 IntAct, MINT YWHAQ anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT YWHAZ Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical, physical association 16376338 , 22653443 , 9620776 , (Europe PMC )0.56 BioGRID, IntAct, MINT YY1 Affinity Capture-Western, Reconstituted Complex, pull down physical, physical association 15210108 , 15295102 , 18026119 , 22440256 , 25402006 , (Europe PMC )0.40 BioGRID, IntAct YY2 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct ZCCHC10 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct ZIC3 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct ZNF24 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct ZNF385A anti bait coimmunoprecipitation physical association 17719541 , (Europe PMC )0.40 IntAct ZNF420 Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down association, direct interaction, physical, physical association 19377469 , 20713054 , (Europe PMC )0.59 BioGRID, IntAct, MINT
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source AR Phenotypic Suppression, two hybrid genetic, physical association 11504717 , 19481544 , (Europe PMC )0.37 BioGRID, IntAct, MINT ARIH2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, pull down, two hybrid pooling approach association, direct interaction, physical, physical association 16169070 , 22819825 , (Europe PMC )0.69 BioGRID, IntAct, MINT ATAD3A anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT ATAD3B anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT ATM Biochemical Activity, Co-localization, Phenotypic Enhancement, Protein-peptide, Reconstituted Complex, experimental interaction detection genetic, phosphorylation reaction, physical 10608806 , 10713094 , 10744722 , 10864201 , 11459832 , 14744854 , 15064416 , 15159397 , 15632067 , 15790808 , 17409407 , 19965871 , 21383020 , 23907539 , 24469230 , 25086746 , 27559048 , 9135004 , 9843217 , (Europe PMC )0.31 BioGRID, IntAct, MINT BAG2 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , 27807478 , (Europe PMC )0.35 BioGRID, IntAct, MINT BAG6 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT BANP Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation association, physical, physical association 19303885 , 20075864 , 22074660 , (Europe PMC )0.50 BioGRID, IntAct, MINT BCL2 Affinity Capture-Western, anti bait coimmunoprecipitation association, physical, physical association 12667443 , 19521340 , 21597459 , 21624955 , (Europe PMC )0.56 BioGRID, IntAct, MINT BCL2L1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence polarization spectroscopy, isothermal titration calorimetry, nuclear magnetic resonance, pull down, surface plasmon resonance, two hybrid association, direct interaction, physical, physical association 12667443 , 14963330 , 16151013 , 20837658 , 21900206 , 24474649 , 24814347 , 25115399 , 26556313 , (Europe PMC )0.37, 0.88 BioGRID, IntAct, MINT BHLHE40 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, imaging technique, pull down association, colocalization, physical, physical association 17347673 , 22723347 , (Europe PMC )0.73 BioGRID, IntAct, MINT BLM Affinity Capture-MS, Affinity Capture-Western, Co-localization, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation association, physical 11399766 , 11781842 , 12080066 , 15364958 , 22653443 , 24239288 , (Europe PMC )0.35 BioGRID, IntAct, MINT BRCA1 Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, coimmunoprecipitation, pull down direct interaction, physical, physical association 14636569 , 14710355 , 15571721 , 16677609 , 16969499 , 19509300 , 21742769 , 26140185 , 9482880 , 9582019 , 9926942 , (Europe PMC )0.54 BioGRID, IntAct, MINT CCDC106 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, fluorescence microscopy, two hybrid pooling approach colocalization, physical, physical association 16169070 , 20159018 , (Europe PMC )0.61 BioGRID, IntAct, MINT CCDC8 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 22084066 , 22653443 , 23443559 , 24711643 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT2 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT3 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT4 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT5 Affinity Capture-MS, Two-hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach association, physical, physical association 16169070 , 22653443 , 23443559 , 25144556 , (Europe PMC )0.55 BioGRID, IntAct, MINT CCT6A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT7 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT8 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CDKN1A Affinity Capture-Western, Co-localization, Two-hybrid, imaging technique, proximity ligation assay, two hybrid colocalization, physical, physical association 11896572 , 12897156 , 16616141 , 17371838 , 21900206 , 25241761 , (Europe PMC )0.65 BioGRID, IntAct, MINT CDKN2A anti tag coimmunoprecipitation, fluorescence microscopy association, colocalization 12740913 , 22653443 , (Europe PMC )0.49 IntAct, MINT CEBPZ Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down physical, physical association 12534345 , (Europe PMC )0.52 BioGRID, IntAct, MINT CHEK1 Affinity Capture-Western, Biochemical Activity, Co-localization, protein kinase assay phosphorylation reaction, physical 10673501 , 11896572 , 12756247 , 15364958 , 16511572 , (Europe PMC )0.44 BioGRID, IntAct, MINT CHEK2 Affinity Capture-Western, Biochemical Activity, experimental interaction detection, protein kinase assay phosphorylation reaction, physical 10673501 , 10710310 , 10724175 , 12810724 , 15862297 , 18833288 , (Europe PMC )0.65 BioGRID, IntAct, MINT COLGALT1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT COPS4 Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 22653443 , 24725084 , (Europe PMC )0.35 BioGRID, IntAct, MINT CREBBP Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-localization, FRET, Phenotypic Suppression, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, competition binding, proximity ligation assay, pull down association, genetic, physical, physical association 10196247 , 10551785 , 10823891 , 10848610 , 11782467 , 12154097 , 12426395 , 14722092 , 14759370 , 15632413 , 16537920 , 17434128 , 18485870 , 18753379 , 19166313 , 19234109 , 19357310 , 19805293 , 19880525 , 20962272 , 21390126 , 22084066 , 23908595 , 25314079 , 25451029 , 26976603 , 27618436 , 9194564 , 9288775 , (Europe PMC )0.91 BioGRID, IntAct, MINT CSNK2A2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT CUL7 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, molecular sieving, nuclear magnetic resonance, tandem affinity purification association, physical, physical association 16547496 , 16875676 , 17229476 , 17298945 , 17332328 , 17942889 , 22653443 , 23443559 , 24711643 , 25003318 , 25609649 , 26186194 , 28514442 , (Europe PMC )0.72 BioGRID, IntAct, MINT CUL9 Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid association, physical, physical association 12526791 , 16875676 , 17229476 , 17332328 , 17380154 , 18230339 , 21487039 , 22653443 , 23443559 , 25609649 , 26186194 , 28514442 , (Europe PMC )0.72 BioGRID, IntAct, MINT DDX5 Affinity Capture-MS, anti bait coimmunoprecipitation, pull down direct interaction, physical, physical association 15660129 , 20818423 , 23443559 , 24219989 , 25144556 , (Europe PMC )0.44, 0.54, 0.66 BioGRID, IntAct, MINT DROSHA anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical association 19626115 , 24219989 , (Europe PMC )0.68 IntAct, MINT DYNC1I1 anti bait coimmunoprecipitation physical association 16616141 , (Europe PMC )0.40 IntAct, MINT EEF2 Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 12891704 , 22653443 , (Europe PMC )0.35 BioGRID, IntAct, MINT EGR1 Affinity Capture-Western, Reconstituted Complex, cosedimentation colocalization, physical 11251186 , 14744935 , 15225550 , 21325822 , (Europe PMC )0.35 BioGRID, IntAct, MINT EP300 Affinity Capture-Luminescence, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-fractionation, Co-localization, Phenotypic Suppression, Protein-peptide, Reconstituted Complex, acetylase assay, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, atomic force microscopy, classical fluorescence spectroscopy, coimmunoprecipitation, isothermal titration calorimetry, nuclear magnetic resonance, pull down, x ray scattering acetylation reaction, association, direct interaction, genetic, physical, physical association 10490106 , 10518217 , 10942770 , 11070080 , 11359905 , 11433299 , 11782467 , 11804596 , 11907332 , 12162806 , 12501250 , 12690203 , 12724314 , 14612423 , 14759370 , 15186775 , 15295102 , 15337767 , 15509808 , 15542844 , 15558054 , 15664194 , 15965232 , 16024799 , 16135789 , 16537920 , 16543236 , 16611888 , 16678111 , 16782091 , 16928824 , 16959611 , 17189186 , 17438265 , 17452980 , 17906639 , 17977830 , 18243116 , 18391200 , 18485870 , 18612383 , 19217391 , 19218448 , 19234109 , 19339993 , 19805293 , 20234175 , 21187340 , 21471221 , 22013068 , 22074660 , 22266186 , 22731250 , 23010591 , 23307557 , 23329847 , 23402884 , 23728348 , 23796514 , 23870121 , 23880760 , 24157709 , 24821727 , 25156994 , 25288747 , 25651062 , 25753752 , 25867071 , 26229107 , 26302407 , 26625199 , 27818144 , 9194564 , 9194565 , 9288740 , 9744860 , 9809062 , 9891054 , (Europe PMC )0.40, 0.97 BioGRID, IntAct, MINT FBXW8 Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification association, physical 22653443 , 25609649 , (Europe PMC )0.53 BioGRID, IntAct, MINT FOXA3 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXB1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXC1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXG1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXJ3 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXK1 tandem affinity purification association 25609649 , (Europe PMC )0.35 IntAct, MINT FOXK2 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXN1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXP1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXQ1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXS1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT GADD45A Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT GLI1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT GRB2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT GSK3B Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, protein kinase assay, two hybrid phosphorylation reaction, physical, physical association 12048243 , 14744935 , 21900206 , (Europe PMC )0.66 BioGRID, IntAct, MINT GTF2H1 Co-crystal Structure, Far Western, Reconstituted Complex, pull down direct interaction, physical 16793543 , 18160537 , 18354501 , 7935417 , 8612585 , (Europe PMC )0.44 BioGRID, IntAct, MINT HDAC1 Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, proximity ligation assay association, physical, physical association 10521394 , 10777477 , 11099047 , 11313951 , 12426395 , 14976551 , 16107876 , 16697957 , 16959611 , 17827154 , 18765668 , 19011633 , 19303885 , 20075864 , 20633551 , 22266186 , 25241761 , 26539911 , (Europe PMC )0.73 BioGRID, IntAct, MINT HDAC8 x-ray crystallography direct interaction 17721440 , (Europe PMC )0.44 IntAct, MINT HERC2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT HINFP Two-hybrid, two hybrid physical, physical association 21516116 , (Europe PMC )0.37 BioGRID, IntAct, MINT HIPK2 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down direct interaction, physical, physical association 11740489 , 11925430 , 15896780 , 16212962 , 17349959 , 21057547 , 25313037 , (Europe PMC )0.71 BioGRID, IntAct, MINT HNRNPK Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down physical, physical association 21821029 , 23092970 , 25144556 , (Europe PMC )0.52, 0.59 BioGRID, IntAct, MINT HNRNPUL1 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, direct interaction, physical association 15907477 , 22653443 , (Europe PMC )0.70 IntAct, MINT HSPA1L Affinity Capture-MS, Co-localization, anti bait coimmunoprecipitation, proximity ligation assay physical, physical association 17184779 , 23443559 , 25241761 , (Europe PMC )0.59 BioGRID, IntAct, MINT HSPA5 anti bait coimmunoprecipitation physical association 17184779 , (Europe PMC )0.40 IntAct, MINT HSPA9 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, direct interaction, physical, physical association 11900485 , 17184779 , 20153329 , 22340593 , 22366412 , 22726440 , 23443559 , 25144556 , (Europe PMC )0.81 BioGRID, IntAct, MINT HSPB1 Affinity Capture-Western, Co-localization, Two-hybrid, anti bait coimmunoprecipitation, proximity ligation assay, two hybrid pooling approach physical, physical association 16169070 , 17184779 , 25241761 , (Europe PMC )0.69 BioGRID, IntAct, MINT HTT Affinity Capture-Western, Reconstituted Complex, biochemical, pull down physical, physical association 10823891 , (Europe PMC )0.52 BioGRID, IntAct, MINT IKBKB Biochemical Activity, anti bait coimmunoprecipitation, protein kinase assay phosphorylation reaction, physical, physical association 19196987 , 19883646 , (Europe PMC )0.61 BioGRID, IntAct, MINT ING2 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 16024799 , 16782091 , (Europe PMC )0.40 BioGRID, IntAct, MINT ING4 Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, coimmunoprecipitation physical, physical association 12750254 , 15251430 , 15882981 , 17954561 , 18775696 , 20053357 , 21177815 , 21454715 , 23967213 , (Europe PMC )0.40 BioGRID, IntAct, MINT JUN anti bait coimmunoprecipitation association 25609649 , (Europe PMC )0.35 IntAct, MINT KAT8 Biochemical Activity, Reconstituted Complex, anti tag coimmunoprecipitation, pull down association, physical, physical association 15960975 , 16601686 , 17189187 , 19854137 , (Europe PMC )0.56 BioGRID, IntAct, MINT KDM1A Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, demethylase assay, pull down association, demethylation reaction, direct interaction, physical, physical association 17805299 , 18573881 , 22653443 , (Europe PMC )0.35, 0.66 BioGRID, IntAct, MINT KHDRBS1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT MAP1B anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy colocalization, physical association 18656471 , (Europe PMC )0.56 IntAct, MINT MAPK8 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation physical, physical association 11108663 , 12514174 , 15538975 , 15580310 , 18813780 , 19651615 , 9393873 , 9724739 , 9732264 , (Europe PMC )0.40 BioGRID, IntAct, MINT MDM2 Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-RNA, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-fractionation, Co-localization, FRET, Far Western, PCA, Phenotypic Suppression, Protein-RNA, Protein-peptide, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, chromatin immunoprecipitation assay, classical fluorescence spectroscopy, cosedimentation in solution, enzyme linked immunosorbent assay, fluorescence polarization spectroscopy, isothermal titration calorimetry, molecular sieving, nuclear magnetic resonance, peptide array, proximity ligation assay, pull down, surface plasmon resonance, two hybrid, ubiquitinase assay, x-ray crystallography association, direct interaction, genetic, physical, physical association, ubiquitination reaction 10196247 , 10202144 , 10347217 , 10435614 , 10488081 , 10561590 , 10562557 , 10640350 , 10681559 , 10722742 , 10766163 , 10827196 , 10889512 , 10980696 , 11046142 , 11070080 , 11094089 , 11112690 , 11178989 , 11284721 , 11285227 , 11351297 , 11384992 , 11431470 , 11486026 , 11562347 , 11572869 , 11597128 , 11697899 , 11709713 , 11713287 , 11713288 , 11714701 , 11744695 , 11839577 , 11925449 , 12167711 , 12208736 , 12381304 , 12426395 , 12552135 , 12612087 , 12620407 , 12690203 , 12842086 , 12897156 , 12915590 , 12944468 , 14499615 , 14517261 , 14559824 , 14596917 , 14612427 , 14671306 , 14702041 , 14704432 , 14741215 , 15001357 , 15013777 , 15053879 , 15058298 , 15064742 , 15094782 , 15122315 , 15144954 , 15154850 , 15210108 , 15242646 , 15247280 , 15280377 , 15295102 , 15308643 , 15313915 , 15358376 , 15542844 , 15550400 , 15558054 , 15604276 , 15824742 , 15848166 , 15908921 , 15933712 , 15950904 , 16023600 , 16055726 , 16107876 , 1614537 , 16152627 , 16159876 , 16173922 , 16201274 , 16212962 , 16215989 , 16331255 , 16338390 , 16414131 , 16432196 , 16547496 , 16579792 , 16595680 , 16624812 , 16678796 , 16751805 , 16845383 , 16857591 , 16861890 , 16866370 , 16870621 , 16905769 , 16964247 , 17056014 , 17080083 , 17098746 , 17116689 , 17139261 , 17159902 , 17268548 , 17290220 , 17297477 , 17301054 , 17302414 , 17310983 , 17318220 , 17347673 , 17363365 , 17369817 , 17380154 , 17426254 , 17438265 , 17470788 , 17525743 , 17591690 , 17616658 , 17666403 , 17848574 , 17875722 , 17908790 , 17936559 , 17989425 , 18061646 , 18172499 , 18223694 , 18234963 , 18309296 , 18316739 , 18332869 , 18467333 , 18485870 , 18541670 , 18566590 , 18604177 , 18665269 , 18813780 , 18815136 , 18981217 , 19033382 , 19071110 , 19081178 , 19085961 , 19098711 , 19106616 , 19153082 , 19160491 , 19166840 , 19188367 , 19223463 , 19234109 , 19255450 , 19303885 , 19305137 , 19332559 , 19357310 , 19411066 , 19411846 , 19483087 , 19568783 , 19590512 , 19597489 , 19656744 , 19805293 , 19816404 , 19837670 , 19857530 , 19941302 , 20047188 , 20080206 , 20124408 , 20173098 , 20174603 , 20234175 , 20235143 , 20395212 , 20479273 , 20484049 , 20542919 , 20570896 , 20588255 , 20591429 , 20591651 , 20639885 , 20657550 , 20659896 , 20660730 , 20694676 , 20705607 , 20708156 , 20837658 , 20847049 , 20959462 , 20962272 , 21060154 , 21071676 , 21075307 , 21084285 , 21084564 , 21088494 , 21098709 , 21132010 , 21149449 , 21170087 , 21261729 , 21268072 , 21316347 , 21317885 , 21454483 , 21465263 , 21471462 , 21478269 , 21561866 , 21572037 , 21584881 , 21726810 , 21750659 , 21857681 , 21887275 , 21925390 , 21965653 , 21986495 , 21988832 , 22032989 , 22083959 , 22084066 , 22085928 , 22103682 , 22124327 , 22157679 , 22227409 , 22262183 , 22266850 , 22266868 , 22301280 , 22318540 , 22331460 , 22366412 , 22374672 , 22389628 , 22391559 , 22411991 , 22444248 , 22474335 , 22487680 , 22510990 , 22525275 , 22575647 , 22588298 , 22653443 , 22659184 , 22737255 , 22807444 , 22819825 , 22912717 , 22914926 , 22916255 , 22920093 , 22948151 , 22975381 , 23134341 , 23150668 , 23169665 , 23201157 , 23246961 , 23252402 , 23261415 , 23318437 , 23370271 , 23402884 , 23443559 , 23483203 , 23572512 , 23609977 , 23671280 , 23728348 , 23776060 , 23776465 , 23802716 , 23826318 , 23880345 , 23946421 , 24127580 , 24200963 , 24207125 , 24240685 , 24314634 , 24361594 , 24413661 , 24462112 , 24488098 , 24567357 , 24621507 , 24643130 , 24659749 , 24667498 , 24842904 , 24926618 , 24980433 , 24998844 , 25103245 , 25156994 , 25168242 , 25241761 , 25277184 , 25283148 , 25312347 , 25313037 , 25362358 , 25384516 , 25417702 , 25464845 , 25512388 , 25543083 , 25609649 , 25624478 , 25637791 , 25739118 , 25954860 , 26001071 , 26186194 , 26203195 , 26238070 , 26350565 , 26475964 , 26540344 , 26556313 , 26578655 , 26673821 , 26720344 , 26876197 , 26882543 , 26883110 , 26908445 , 27031960 , 27106262 , 27129163 , 27215386 , 27282385 , 27308622 , 27336364 , 27462439 , 27543608 , 27807478 , 27811966 , 27856536 , 27886165 , 27893708 , 28082682 , 28223335 , 28362432 , 28394340 , 28514442 , 28542145 , 28549433 , 28553961 , 28605833 , 7686617 , 7689721 , 8058315 , 8875929 , 9131587 , 9223638 , 9271120 , 9278461 , 9363941 , 9450543 , 9529249 , 9582019 , 9724739 , 9809062 , 9824166 , (Europe PMC )0.99 BioGRID, IntAct, MINT MDM4 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-localization, PCA, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, enzyme linked immunosorbent assay, fluorescence microscopy, fluorescence polarization spectroscopy, isothermal titration calorimetry, nuclear magnetic resonance, pull down, tandem affinity purification, ubiquitinase assay association, colocalization, direct interaction, physical, physical association, ubiquitination reaction 10075736 , 10608892 , 10827196 , 11223036 , 12370303 , 12393902 , 12874296 , 15604276 , 15916963 , 16024788 , 16227609 , 17080083 , 17301054 , 17875722 , 18316739 , 18485870 , 18677113 , 19075013 , 19153082 , 19255450 , 19305137 , 19432880 , 19521340 , 20174603 , 20515689 , 20705607 , 20724842 , 21075307 , 21088494 , 21925390 , 21965653 , 22266850 , 22374672 , 22807444 , 23028042 , 23671280 , 23946421 , 24127580 , 24445145 , 24659749 , 24667498 , 25464845 , 25609649 , 25825738 , 26148237 , 26186194 , 26876197 , 27114532 , 28487147 , 28514442 , 9226370 , (Europe PMC )0.96 BioGRID, IntAct, MINT MED1 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down physical, physical association 11118038 , 15848166 , 9444950 , (Europe PMC )0.52 BioGRID, IntAct, MINT MKRN1 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down direct interaction, physical, physical association 19536131 , (Europe PMC )0.60 BioGRID, IntAct, MINT MOV10 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT MPDZ anti tag coimmunoprecipitation association, physical association 22653443 , (Europe PMC )0.50 IntAct, MINT MPP5 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT MRPS22 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT MT1A anti bait coimmunoprecipitation, pull down direct interaction, physical association 16442532 , (Europe PMC )0.54 IntAct, MINT MTOR Affinity Capture-Western, Synthetic Lethality, anti bait coimmunoprecipitation association, genetic, physical 19619545 , 27438146 , (Europe PMC )0.35 BioGRID, IntAct, MINT NAP1L1 pull down direct interaction 14966293 , (Europe PMC )0.44 IntAct, MINT NCL Affinity Capture-Western, Far Western, Reconstituted Complex, far western blotting, pull down direct interaction, physical 12138209 , 22103682 , 26238070 , (Europe PMC )0.56 BioGRID, IntAct, MINT NCOR2 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, competition binding, pull down direct interaction, physical association 24449765 , (Europe PMC )0.65 IntAct, MINT NEDD8 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT NEURL4 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT NFATC1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT NMT1 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 16530191 , (Europe PMC )0.40 BioGRID, IntAct, MINT NMT2 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 16530191 , (Europe PMC )0.40 BioGRID, IntAct, MINT NPAS3 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT NPM1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, coimmunoprecipitation, cross-linking study, surface plasmon resonance association, direct interaction, physical, physical association 12080348 , 15144954 , 15964625 , 16376884 , 16740634 , 23443559 , (Europe PMC )0.35, 0.56, 0.68 BioGRID, IntAct, MINT NR0B2 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 22575647 , 22737255 , (Europe PMC )0.52 BioGRID, IntAct, MINT NR4A1 Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down, two hybrid array physical, physical association 17139261 , (Europe PMC )0.58 BioGRID, IntAct, MINT NRDC anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical association 22653443 , (Europe PMC )0.58 IntAct, MINT NT5C2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT NUDT16L1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT OBSL1 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, tandem affinity purification association, physical 22653443 , 23443559 , 24711643 , 25609649 , (Europe PMC )0.53 BioGRID, IntAct, MINT OLA1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT OTUB1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, direct interaction, physical, physical association 22124327 , 24403071 , 27561390 , (Europe PMC )0.63 BioGRID, IntAct, MINT PAGR1 pull down physical association 19039327 , (Europe PMC )0.40 IntAct, MINT PARD3 anti tag coimmunoprecipitation association, physical association 22653443 , (Europe PMC )0.50 IntAct, MINT PARP1 Affinity Capture-Western, Far Western, Reconstituted Complex, anti bait coimmunoprecipitation, coimmunoprecipitation, pull down association, direct interaction, physical, physical association 12898523 , 14627987 , 15044383 , 9312059 , 9565608 , (Europe PMC )0.75 BioGRID, IntAct, MINT PES1 tandem affinity purification association 25609649 , (Europe PMC )0.35 IntAct, MINT PHB Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy, fluorescence microscopy colocalization, physical, physical association 14500729 , 16319068 , 20134482 , 24380853 , (Europe PMC )0.62 BioGRID, IntAct, MINT PIN1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, chromatin immunoprecipitation assay, coimmunoprecipitation, pull down, two hybrid association, physical, physical association 12388558 , 12397362 , 17906639 , 21741598 , 21900206 , (Europe PMC )0.85 BioGRID, IntAct, MINT PLK1 Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay, two hybrid association, phosphorylation reaction, physical, physical association 16753148 , 19833129 , 22653443 , (Europe PMC )0.74 BioGRID, IntAct, MINT PLOD3 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT POLRMT Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT PPM1G anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT PPP1CA Two-hybrid, two hybrid physical, physical association 15231748 , (Europe PMC )0.37 BioGRID, IntAct, MINT PPP1R13B Affinity Capture-Western, Synthetic Growth Defect, anti bait coimmunoprecipitation association, genetic, physical 21513714 , 23284306 , (Europe PMC )0.35 BioGRID, IntAct, MINT PPP1R13L Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, fluorescence microscopy, pull down, solid phase assay association, colocalization, direct interaction, physical, physical association 12524540 , 17906639 , 18275817 , 20840860 , 21513714 , 23443559 , 23623661 , (Europe PMC )0.81 BioGRID, IntAct, MINT PPP2R1A Affinity Capture-MS, Co-localization, anti bait coimmunoprecipitation, proximity ligation assay, pull down physical, physical association 12665691 , 17245430 , 25241761 , (Europe PMC )0.66 BioGRID, IntAct, MINT PPP2R2A anti bait coimmunoprecipitation physical association 17245430 , (Europe PMC )0.40 IntAct, MINT PPP2R5C Co-localization, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, proximity ligation assay association, physical, physical association 17245430 , 21460856 , 25241761 , (Europe PMC )0.35, 0.69 BioGRID, IntAct, MINT PSMC1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT PSMD2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT PSMD5 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT PSME3 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, physical, physical association 18309296 , 21084564 , (Europe PMC )0.58 BioGRID, IntAct, MINT PTBP3 anti bait coimmunoprecipitation association 22575643 , (Europe PMC )0.35 IntAct, MINT PTK2 Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy, proximity ligation assay, pull down colocalization, direct interaction, physical, physical association 15855171 , 18206965 , 19857493 , 25241761 , (Europe PMC )0.76 BioGRID, IntAct, MINT PYCR3 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT RABGAP1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT RANBP9 Two-hybrid, anti tag coimmunoprecipitation association, physical 18307271 , 22653443 , (Europe PMC )0.35 BioGRID, IntAct, MINT RAP1B Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT RASGRF1 anti bait coimmunoprecipitation physical association 16753148 , (Europe PMC )0.40 IntAct, MINT RBX1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT RCC1 Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT RCHY1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, imaging technique, nuclear magnetic resonance, pull down, two hybrid colocalization, direct interaction, physical, physical association 12654245 , 17568776 , 19043414 , 19483087 , 20452352 , 21084285 , 21791603 , 21988832 , 24367557 , 25116336 , (Europe PMC )0.85 BioGRID, IntAct, MINT RFWD2 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, experimental interaction detection, pull down association, direct interaction, physical association, ubiquitination reaction 15103385 , 21625211 , (Europe PMC )0.72 IntAct, MINT RNASEL Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT RPA2 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT RPL5 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 15308643 , 22653443 , 23169665 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT RPS27A Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 21561866 , 22653443 , (Europe PMC )0.35 BioGRID, IntAct, MINT RYBP Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical, physical association 19098711 , (Europe PMC )0.50 BioGRID, IntAct, MINT S100A1 molecular sieving direct interaction 20591429 , (Europe PMC )0.44 IntAct, MINT S100A2 molecular sieving direct interaction 20591429 , (Europe PMC )0.44 IntAct, MINT S100A4 Affinity Capture-Western, Reconstituted Complex, confocal microscopy, cross-linking study, far western blotting, fluorescence polarization spectroscopy, molecular sieving, proximity ligation assay colocalization, direct interaction, physical, physical association 11527429 , 19740107 , 20070253 , 20591429 , 23752197 , (Europe PMC )0.79 BioGRID, IntAct, MINT S100A6 Reconstituted Complex, molecular sieving direct interaction, physical 20591429 , 23796514 , (Europe PMC )0.44 BioGRID, IntAct, MINT S100B Affinity Capture-Western, molecular sieving direct interaction, physical 15178678 , 20591429 , (Europe PMC )0.44 BioGRID, IntAct, MINT SAE1 anti tag coimmunoprecipitation covalent binding 15327968 , (Europe PMC )0.44 IntAct, MINT SAFB Affinity Capture-Western, anti bait coimmunoprecipitation, fluorescence microscopy, pull down colocalization, physical, physical association 21130767 , (Europe PMC )0.56 BioGRID, IntAct, MINT SAFB2 Affinity Capture-Western, pull down physical, physical association 21130767 , (Europe PMC )0.40 BioGRID, IntAct, MINT SARS2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT SFN Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, isothermal titration calorimetry, x-ray crystallography association, direct interaction, physical 11896572 , 14517281 , 17546054 , 20206173 , 21625211 , (Europe PMC )0.67 BioGRID, IntAct, MINT SIN3A anti bait coimmunoprecipitation, pull down physical association 10823891 , 11359905 , (Europe PMC )0.59 IntAct, MINT SKP1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT SMARCA5 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT SMARCAL1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT SMG5 Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification association, physical 22653443 , 25609649 , (Europe PMC )0.53 BioGRID, IntAct, MINT SMG7 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 22653443 , 27462439 , (Europe PMC )0.35 BioGRID, IntAct, MINT SMN1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid physical, physical association 11704667 , 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT SMYD2 Affinity Capture-Western, Biochemical Activity, isothermal titration calorimetry, methyltransferase assay, methyltransferase radiometric assay, tandem affinity purification, x-ray crystallography adp ribosylation reaction, direct interaction, methylation reaction, physical 17108971 , 17805299 , 18065756 , 21782458 , 25609649 , (Europe PMC )0.81 BioGRID, IntAct, MINT SNAI1 Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 20385133 , 28067227 , (Europe PMC )0.52 BioGRID, IntAct, MINT SP1 Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation physical, physical association 12665570 , 15574328 , 15674334 , 15710382 , 16740634 , 18765668 , 19846904 , 20570896 , 21325822 , 21831840 , 23650532 , 8463313 , 9492043 , 9685344 , (Europe PMC )0.59 BioGRID, IntAct, MINT SRPK1 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down physical association 21130767 , (Europe PMC )0.59 IntAct, MINT SYVN1 Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, imaging technique, pull down colocalization, physical, physical association 17170702 , 21903092 , 26254280 , (Europe PMC )0.61 BioGRID, IntAct, MINT TBP Affinity Capture-Western, Reconstituted Complex, far western blotting, pull down direct interaction, physical, physical association 10359315 , 11313951 , 12379483 , 1465435 , 7799929 , 8083962 , 9349482 , (Europe PMC )0.40, 0.44 BioGRID, IntAct, MINT TCF4 Affinity Capture-MS, Reconstituted Complex, pull down, tandem affinity purification association, physical, physical association 25402006 , 25609649 , (Europe PMC )0.56 BioGRID, IntAct, MINT TCP1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT TDRD12 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TK1 Two-hybrid, two hybrid, two hybrid pooling approach physical, physical association 16169070 , 21900206 , (Europe PMC )0.55 BioGRID, IntAct, MINT TOE1 anti bait coimmunoprecipitation, biophysical, pull down association, direct interaction 19508870 , (Europe PMC )0.58 IntAct, MINT TOP3A anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TOPORS Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation physical, physical association 11842245 , 15247280 , 16122737 , 17290218 , 17803295 , (Europe PMC )0.40 BioGRID, IntAct, MINT TP53 Affinity Capture-Western, Co-crystal Structure, Co-fractionation, Co-purification, FRET, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, comigration in gel electrophoresis, comigration in non denaturing gel electrophoresis, cosedimentation in solution, cross-linking study, electron microscopy, mass spectrometry studies of complexes, molecular sieving, nuclear magnetic resonance, pull down, tandem affinity purification, transmission electron microscopy, two hybrid, ubiquitin reconstruction, x ray scattering, x-ray crystallography association, direct interaction, physical, physical association 14580323 , 14985081 , 15383276 , 16009130 , 16291740 , 16461914 , 17332328 , 17612295 , 17620598 , 18087040 , 18414054 , 19011633 , 19339993 , 19667193 , 20004160 , 20080206 , 20159469 , 20235143 , 20364130 , 21084564 , 21178074 , 21231916 , 21522129 , 21988832 , 22522597 , 22653443 , 22819825 , 22972749 , 24037342 , 24374182 , 24722987 , 25402006 , 25603536 , 25609649 , 27462439 , 8035799 , (Europe PMC )0.98 BioGRID, IntAct, MINT TP53BP1 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, classical fluorescence spectroscopy, nuclear magnetic resonance, peptide array, pull down, two hybrid, x-ray crystallography association, direct interaction, physical association 11877378 , 14985081 , 17805299 , 19433796 , 22653443 , 25579814 , 25651062 , 25837623 , (Europe PMC )0.83, 0.88 IntAct, MINT TP53BP2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, pull down, solid phase assay, two hybrid, x-ray crystallography association, direct interaction, physical, physical association 14985081 , 18275817 , 21513714 , 8016121 , 8668206 , 8875926 , (Europe PMC )0.83 BioGRID, IntAct, MINT TPT1 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, two hybrid, two hybrid pooling approach physical, physical association 21081126 , 22157679 , 22451927 , (Europe PMC )0.71 BioGRID, IntAct, MINT TRAF1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TSPAN10 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TSPYL4 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TUBB Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT TUBB2A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT TUBB3 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TWNK anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT UBC Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, physical, physical association 17139261 , 17159902 , 17170702 , 17268548 , 17290220 , 17568776 , 18309296 , 18388957 , 18566590 , 19098711 , 19536131 , 19619542 , 19798103 , 25168242 , 25471832 , (Europe PMC )0.96 BioGRID, IntAct, MINT UBE2I Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, pull down, two hybrid direct interaction, physical, physical association 10380882 , 10562557 , 10788439 , 10961991 , 11853669 , 12565873 , 15327968 , 16122737 , 16442531 , 17060459 , 17709345 , 18624398 , 19684601 , 21829513 , 22214662 , 23202365 , 23772552 , 8921390 , (Europe PMC )0.66 BioGRID, IntAct, MINT UBE3A molecular sieving, pull down, surface plasmon resonance, two hybrid array, two hybrid prey pooling approach, x-ray crystallography association, direct interaction, physical association 12620801 , 16493710 , 26789255 , 29426014 , (Europe PMC )0.49, 0.77 IntAct, MINT UFD1 two hybrid physical association 21900206 , (Europe PMC )0.37 IntAct, MINT USP28 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT USP29 Affinity Capture-Western, anti tag coimmunoprecipitation physical, physical association 21285945 , (Europe PMC )0.40 BioGRID, IntAct, MINT USP42 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation direct interaction, physical, physical association 22085928 , (Europe PMC )0.40, 0.54 BioGRID, IntAct, MINT USP7 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, classical fluorescence spectroscopy, coimmunoprecipitation, experimental interaction detection, isothermal titration calorimetry, molecular sieving, nuclear magnetic resonance, pull down, x-ray crystallography association, deubiquitination reaction, direct interaction, physical, physical association 11923872 , 14506283 , 15916963 , 16402859 , 16474402 , 16845383 , 17268548 , 17380154 , 17525743 , 20713061 , 20816748 , 21170034 , 21845734 , 22056774 , 22084066 , 22653443 , 23382381 , 23388826 , 24462112 , 25283148 , 26238070 , 26460617 , (Europe PMC )0.97 BioGRID, IntAct, MINT WWOX Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation physical, physical association 11058590 , 15580310 , 16219768 , (Europe PMC )0.40 BioGRID, IntAct, MINT XPO1 anti bait coimmunoprecipitation physical association 17268548 , 18952844 , (Europe PMC )0.59 IntAct, MINT YTHDC2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT YWHAE Affinity Capture-MS, fluorescence polarization spectroscopy association, physical 18812399 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT YWHAG anti tag coimmunoprecipitation, coimmunoprecipitation, fluorescence polarization spectroscopy association 18812399 , 19933256 , 22653443 , (Europe PMC )0.64 IntAct, MINT YWHAQ anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT YWHAZ Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical, physical association 16376338 , 22653443 , 9620776 , (Europe PMC )0.56 BioGRID, IntAct, MINT ZNF420 Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down association, direct interaction, physical, physical association 19377469 , 20713054 , (Europe PMC )0.59 BioGRID, IntAct, MINT
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ABCE1 Affinity Capture-MS physical 25659154 , (Europe PMC )NA BioGRID ABL1 Reconstituted Complex physical 10629029 , (Europe PMC )NA BioGRID ABR Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ABRAXAS2 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 25283148 , 26186194 , 28514442 , (Europe PMC )NA BioGRID ACKR3 Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID ACSL4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ACTA2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ACTB Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID ACTBL2 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID ACTL6A Affinity Capture-Western physical 17878219 , (Europe PMC )NA BioGRID ACVR1C Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ADAM28 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ADH5 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID AGBL2 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID AGO1 Affinity Capture-MS, Affinity Capture-Western physical 20308539 , 24778252 , (Europe PMC )NA BioGRID AGO2 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID AGT Two-hybrid physical 22416758 , (Europe PMC )NA BioGRID AIFM2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID AIMP2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, pull down, two hybrid direct interaction, physical, physical association 18695251 , (Europe PMC )0.59 BioGRID, IntAct AIPL1 Affinity Capture-MS, inference by socio-affinity scoring, tandem affinity purification association, physical, physical association 27173435 , (Europe PMC )0.51 BioGRID, IntAct AKAP12 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ALYREF Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID ANG Affinity Capture-Western physical 22266868 , (Europe PMC )NA BioGRID ANK2 Reconstituted Complex, display technology physical, physical association 20195357 , (Europe PMC )0.40 BioGRID, IntAct ANKRD2 Affinity Capture-Western, Reconstituted Complex physical 15136035 , (Europe PMC )NA BioGRID ANXA2 Reconstituted Complex physical 9315650 , (Europe PMC )NA BioGRID ANXA3 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct ANXA7 Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT APEX1 Affinity Capture-Western, Co-purification physical 15824742 , 9119221 , (Europe PMC )NA BioGRID APOH Two-hybrid, two hybrid physical, physical association 18624398 , (Europe PMC )0.37 BioGRID, IntAct APPL1 Two-hybrid, two hybrid array physical, physical association 25814554 , (Europe PMC )0.37 BioGRID, IntAct APTX Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down association, physical 15044383 , (Europe PMC )0.46 BioGRID, IntAct AR Phenotypic Suppression, two hybrid genetic, physical association 11504717 , 19481544 , (Europe PMC )0.37 BioGRID, IntAct, MINT ARHGEF17 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ARID1A Affinity Capture-Western, Reconstituted Complex physical 21900401 , (Europe PMC )NA BioGRID ARID3A Affinity Capture-Western physical 15017387 , (Europe PMC )NA BioGRID ARIH2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, pull down, two hybrid pooling approach association, direct interaction, physical, physical association 16169070 , 22819825 , (Europe PMC )0.69 BioGRID, IntAct, MINT ARL3 Synthetic Growth Defect, Two-hybrid, two hybrid pooling approach genetic, physical, physical association 16169070 , 23284306 , (Europe PMC )0.37 BioGRID, IntAct ARMCX5 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ARPP21 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ARRB1 anti bait coimmunoprecipitation association, physical association 21857681 , (Europe PMC )0.50 IntAct ASF1A Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID ASH2L Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, physical 19433796 , 23870121 , (Europe PMC )0.64 BioGRID, IntAct ASPM Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID ATAD3A anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT ATAD3B anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT ATF3 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid pooling approach physical, physical association 11792711 , 15933712 , 16169070 , 24554706 , (Europe PMC )0.37 BioGRID, IntAct ATG7 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down physical association 22499945 , (Europe PMC )0.40, 0.52 IntAct ATM Biochemical Activity, Co-localization, Phenotypic Enhancement, Protein-peptide, Reconstituted Complex, experimental interaction detection genetic, phosphorylation reaction, physical 10608806 , 10713094 , 10744722 , 10864201 , 11459832 , 14744854 , 15064416 , 15159397 , 15632067 , 15790808 , 17409407 , 19965871 , 21383020 , 23907539 , 24469230 , 25086746 , 27559048 , 9135004 , 9843217 , (Europe PMC )0.31 BioGRID, IntAct, MINT ATP5F1A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ATR Affinity Capture-Western, Biochemical Activity, Protein-peptide, Reconstituted Complex, Synthetic Growth Defect, protein kinase assay genetic, phosphorylation reaction, physical 10435622 , 10608806 , 11459832 , 15159397 , 15775976 , 16293623 , 20798688 , 23284306 , (Europe PMC )0.44 BioGRID, IntAct ATRX Affinity Capture-MS physical 23329831 , (Europe PMC )NA BioGRID ATXN3 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 27851749 , (Europe PMC )NA BioGRID AURKA Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Phenotypic Suppression, Reconstituted Complex, Two-hybrid genetic, physical 12198151 , 14702041 , 23201157 , 26186194 , 28514442 , (Europe PMC )NA BioGRID AURKB Affinity Capture-Western, protein kinase assay phosphorylation reaction, physical 20959462 , 29340707 , (Europe PMC )0.44 BioGRID, IntAct AXIN1 Affinity Capture-Western, Phenotypic Suppression, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation genetic, physical, physical association 21057547 , 23826318 , (Europe PMC )0.52 BioGRID, IntAct BABAM2 Affinity Capture-MS, Affinity Capture-Western, Co-purification physical 14636569 , (Europe PMC )NA BioGRID BACH1 Affinity Capture-Western, Reconstituted Complex physical 19011633 , (Europe PMC )NA BioGRID BAG1 Phenotypic Suppression genetic 9582267 , (Europe PMC )NA BioGRID BAG2 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , 27807478 , (Europe PMC )0.35 BioGRID, IntAct, MINT BAG5 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 25144556 , 27807478 , (Europe PMC )NA BioGRID BAG6 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT BAIAP2L1 Affinity Capture-Western, Reconstituted Complex physical 21887275 , (Europe PMC )NA BioGRID BAK1 Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Reconstituted Complex physical 15077116 , 21712378 , 25408501 , 27818144 , (Europe PMC )NA BioGRID BANP Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation association, physical, physical association 19303885 , 20075864 , 22074660 , (Europe PMC )0.50 BioGRID, IntAct, MINT BARD1 Affinity Capture-MS, Affinity Capture-Western, Co-localization, anti bait coimmunoprecipitation physical, physical association 14636569 , 15782130 , 21742769 , 26022179 , (Europe PMC )0.40 BioGRID, IntAct BAX Affinity Capture-Western, Co-localization, Reconstituted Complex, proximity ligation assay physical, physical association 25115399 , 25241761 , (Europe PMC )0.40 BioGRID, IntAct BCL2 Affinity Capture-Western, anti bait coimmunoprecipitation association, physical, physical association 12667443 , 19521340 , 21597459 , 21624955 , (Europe PMC )0.56 BioGRID, IntAct, MINT BCL2L1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence polarization spectroscopy, isothermal titration calorimetry, nuclear magnetic resonance, pull down, surface plasmon resonance, two hybrid association, direct interaction, physical, physical association 12667443 , 14963330 , 16151013 , 20837658 , 21900206 , 24474649 , 24814347 , 25115399 , 26556313 , (Europe PMC )0.37, 0.88 BioGRID, IntAct, MINT BCL2L12 Reconstituted Complex physical 20837658 , (Europe PMC )NA BioGRID BCL2L2 Affinity Capture-Western, Protein-peptide, Reconstituted Complex physical 24491548 , 25115399 , (Europe PMC )NA BioGRID BCL6 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct BCR Co-localization, Two-hybrid, proximity ligation assay, two hybrid pooling approach physical, physical association 16169070 , 25241761 , (Europe PMC )0.57 BioGRID, IntAct BECN1 Affinity Capture-Western physical 28128446 , (Europe PMC )NA BioGRID BHLHE40 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, imaging technique, pull down association, colocalization, physical, physical association 17347673 , 22723347 , (Europe PMC )0.73 BioGRID, IntAct, MINT BIRC6 Affinity Capture-Western physical 25196217 , (Europe PMC )NA BioGRID BLM Affinity Capture-MS, Affinity Capture-Western, Co-localization, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation association, physical 11399766 , 11781842 , 12080066 , 15364958 , 22653443 , 24239288 , (Europe PMC )0.35 BioGRID, IntAct, MINT BMI1 Affinity Capture-Western physical 22907436 , 24039897 , (Europe PMC )NA BioGRID BMP1 Two-hybrid, two hybrid physical, physical association 18624398 , (Europe PMC )0.37 BioGRID, IntAct BMX anti bait coimmunoprecipitation physical association 16186805 , (Europe PMC )0.40 IntAct BRCA1 Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, coimmunoprecipitation, pull down direct interaction, physical, physical association 14636569 , 14710355 , 15571721 , 16677609 , 16969499 , 19509300 , 21742769 , 26140185 , 9482880 , 9582019 , 9926942 , (Europe PMC )0.54 BioGRID, IntAct, MINT BRCA2 Affinity Capture-MS, Affinity Capture-Western, Co-purification, classical fluorescence spectroscopy, isothermal titration calorimetry, nuclear magnetic resonance, pull down direct interaction, physical 14636569 , 20421506 , 9811893 , (Europe PMC )0.65 BioGRID, IntAct BRCC3 Affinity Capture-MS, Affinity Capture-Western, Co-purification physical 14636569 , (Europe PMC )NA BioGRID BRD7 Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy, pull down, two hybrid colocalization, physical, physical association 20228809 , 20660729 , (Europe PMC )0.73 BioGRID, IntAct BRD8 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID BRF1 Affinity Capture-Western physical 8943363 , (Europe PMC )NA BioGRID BRINP1 Affinity Capture-Western physical 25732823 , (Europe PMC )NA BioGRID BTBD2 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.51 BioGRID, IntAct BTRC Affinity Capture-Western, anti tag coimmunoprecipitation physical, physical association 19196987 , 21521785 , (Europe PMC )0.40 BioGRID, IntAct C10orf90 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 24240685 , 26223354 , (Europe PMC )NA BioGRID C12orf49 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID CABLES1 Affinity Capture-Western, coimmunoprecipitation physical, physical association 11706030 , 14637168 , (Europe PMC )0.40 BioGRID, IntAct CABLES2 Affinity Capture-Western physical 14637168 , (Europe PMC )NA BioGRID CAD Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID CALD1 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID CAPG Two-hybrid physical 18307271 , (Europe PMC )NA BioGRID CAPN1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID CAPZB Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID CARM1 Reconstituted Complex physical 15186775 , (Europe PMC )NA BioGRID CASP8 Affinity Capture-Western physical 17290218 , (Europe PMC )NA BioGRID CCAR1 Affinity Capture-Western physical 18382127 , (Europe PMC )NA BioGRID CCAR2 anti tag coimmunoprecipitation physical interaction 18235501 , (Europe PMC )0.27 IntAct CCDC106 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, fluorescence microscopy, two hybrid pooling approach colocalization, physical, physical association 16169070 , 20159018 , (Europe PMC )0.61 BioGRID, IntAct, MINT CCDC8 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 22084066 , 22653443 , 23443559 , 24711643 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCL18 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct CCNA2 Reconstituted Complex physical 10884347 , (Europe PMC )NA BioGRID CCND1 Affinity Capture-Western physical 27129163 , (Europe PMC )NA BioGRID CCNG1 Affinity Capture-Western, Reconstituted Complex physical 12556559 , 12642871 , (Europe PMC )NA BioGRID CCNH Affinity Capture-Western, Far Western physical 9840937 , (Europe PMC )NA BioGRID CCT2 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT3 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT4 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT5 Affinity Capture-MS, Two-hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach association, physical, physical association 16169070 , 22653443 , 23443559 , 25144556 , (Europe PMC )0.55 BioGRID, IntAct, MINT CCT6A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT7 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CCT8 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT CDC14A Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 10644693 , (Europe PMC )NA BioGRID CDC14B Affinity Capture-Western, Reconstituted Complex physical 10644693 , (Europe PMC )NA BioGRID CDC42 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct CDK1 Affinity Capture-Western, Biochemical Activity physical 10884347 , 11327730 , (Europe PMC )NA BioGRID CDK2 Biochemical Activity, Co-localization, proximity ligation assay physical, physical association 10884347 , 19556892 , 25241761 , (Europe PMC )0.40 BioGRID, IntAct CDK5 Affinity Capture-Western, Reconstituted Complex physical 17591690 , (Europe PMC )NA BioGRID CDK7 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 9315650 , 9372954 , 9840937 , (Europe PMC )NA BioGRID CDK8 Reconstituted Complex physical 10024883 , (Europe PMC )NA BioGRID CDK9 Affinity Capture-Western, Biochemical Activity, Phenotypic Suppression, Reconstituted Complex genetic, physical 10656684 , 16741955 , (Europe PMC )NA BioGRID CDKN1A Affinity Capture-Western, Co-localization, Two-hybrid, imaging technique, proximity ligation assay, two hybrid colocalization, physical, physical association 11896572 , 12897156 , 16616141 , 17371838 , 21900206 , 25241761 , (Europe PMC )0.65 BioGRID, IntAct, MINT CDKN1C Affinity Capture-MS physical 12665691 , (Europe PMC )NA BioGRID CDKN2A Affinity Capture-Western physical 12446718 , 14612427 , 20395212 , 9529249 , 9653180 , 9724636 , (Europe PMC )NA BioGRID CDKN2A anti tag coimmunoprecipitation, fluorescence microscopy association, colocalization 12740913 , 22653443 , (Europe PMC )0.49 IntAct, MINT CDKN2C Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct CEBPB anti bait coimmunoprecipitation, fluorescence microscopy, pull down colocalization, physical association 16227626 , (Europe PMC )0.56 IntAct CEBPZ Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down physical, physical association 12534345 , (Europe PMC )0.52 BioGRID, IntAct, MINT CELA2B Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID CENPA Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID CEP120 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP128 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP135 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP152 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CEP55 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID CETP Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID CFLAR Affinity Capture-Western physical 18559494 , 21474069 , (Europe PMC )NA BioGRID CFTR Affinity Capture-MS physical 26618866 , (Europe PMC )NA BioGRID CHD3 Two-hybrid physical 10961991 , 15383276 , (Europe PMC )NA BioGRID CHD8 Affinity Capture-Western physical 19151705 , (Europe PMC )NA BioGRID CHEK1 Affinity Capture-Western, Biochemical Activity, Co-localization, protein kinase assay phosphorylation reaction, physical 10673501 , 11896572 , 12756247 , 15364958 , 16511572 , (Europe PMC )0.44 BioGRID, IntAct, MINT CHEK2 Affinity Capture-Western, Biochemical Activity, experimental interaction detection, protein kinase assay phosphorylation reaction, physical 10673501 , 10710310 , 10724175 , 12810724 , 15862297 , 18833288 , (Europe PMC )0.65 BioGRID, IntAct, MINT CHMP4B Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID CHUK Affinity Capture-Western physical 17434128 , (Europe PMC )NA BioGRID CITED1 chromatin immunoprecipitation assay association 20227041 , (Europe PMC )0.35 IntAct CKAP4 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID CLCA3P Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID CLK3 Affinity Capture-MS, tandem affinity purification association, physical 23602568 , (Europe PMC )0.35 BioGRID, IntAct CLTA Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID CLTB Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID CLTC Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID COLGALT1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT COP1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 15103385 , 16931761 , 21625211 , 23736031 , 27534417 , (Europe PMC )NA BioGRID COPS2 Affinity Capture-Western physical 16045761 , (Europe PMC )NA BioGRID COPS4 Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 22653443 , 24725084 , (Europe PMC )0.35 BioGRID, IntAct, MINT COPS5 Affinity Capture-Western, Far Western, Reconstituted Complex physical 11285227 , 16624822 , 16936264 , 17879958 , 24725084 , (Europe PMC )NA BioGRID CORO1C Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID COX17 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct CPA5 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID CPNE7 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID CREB1 Affinity Capture-Western, Co-localization, Reconstituted Complex, proximity ligation assay physical, physical association 10848610 , 16611888 , 21295542 , 25241761 , (Europe PMC )0.40 BioGRID, IntAct CREBBP Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-localization, FRET, Phenotypic Suppression, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, competition binding, proximity ligation assay, pull down association, genetic, physical, physical association 10196247 , 10551785 , 10823891 , 10848610 , 11782467 , 12154097 , 12426395 , 14722092 , 14759370 , 15632413 , 16537920 , 17434128 , 18485870 , 18753379 , 19166313 , 19234109 , 19357310 , 19805293 , 19880525 , 20962272 , 21390126 , 22084066 , 23908595 , 25314079 , 25451029 , 26976603 , 27618436 , 9194564 , 9288775 , (Europe PMC )0.91 BioGRID, IntAct, MINT CREBZF Affinity Capture-Western physical 24200963 , (Europe PMC )NA BioGRID CRK Two-hybrid, two hybrid array physical, physical association 25814554 , (Europe PMC )0.37 BioGRID, IntAct CRTC2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID CRYAB Affinity Capture-Western physical 19343786 , 19799611 , (Europe PMC )NA BioGRID CSE1L anti bait coimmunoprecipitation, cross-linking study direct interaction, physical association 17719542 , (Europe PMC )0.54 IntAct CSNK1A1 Affinity Capture-Western physical 19759023 , 27114532 , (Europe PMC )NA BioGRID CSNK1D Affinity Capture-Western, Biochemical Activity, Co-localization, proximity ligation assay physical, physical association 16870621 , 17101137 , 18246126 , 25241761 , (Europe PMC )0.40 BioGRID, IntAct CSNK1E Co-localization, proximity ligation assay physical, physical association 25241761 , (Europe PMC )0.40 BioGRID, IntAct CSNK2A1 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, protein kinase assay, proximity ligation assay phosphorylation reaction, physical, physical association 12628923 , 15358769 , 22975381 , 23443559 , 24725084 , 25241761 , (Europe PMC )0.61 BioGRID, IntAct CSNK2A2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT CSNK2B PCA physical 21675959 , (Europe PMC )NA BioGRID CTBP1 Affinity Capture-Western physical 18765668 , (Europe PMC )NA BioGRID CUL4A Affinity Capture-Western physical 16861890 , (Europe PMC )NA BioGRID CUL4B Affinity Capture-Western physical 24452595 , (Europe PMC )NA BioGRID CUL7 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, molecular sieving, nuclear magnetic resonance, tandem affinity purification association, physical, physical association 16547496 , 16875676 , 17229476 , 17298945 , 17332328 , 17942889 , 22653443 , 23443559 , 24711643 , 25003318 , 25609649 , 26186194 , 28514442 , (Europe PMC )0.72 BioGRID, IntAct, MINT CUL9 Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid association, physical, physical association 12526791 , 16875676 , 17229476 , 17332328 , 17380154 , 18230339 , 21487039 , 22653443 , 23443559 , 25609649 , 26186194 , 28514442 , (Europe PMC )0.72 BioGRID, IntAct, MINT CXCL8 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID CXXC1 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, cross-linking study, pull down association, physical, physical association 23870121 , (Europe PMC )0.60 BioGRID, IntAct CYLD Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 27561390 , (Europe PMC )NA BioGRID CYP20A1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID DAB2IP Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID DACH1 Affinity Capture-Western physical 23798621 , (Europe PMC )NA BioGRID DAPK1 Affinity Capture-Western physical 17339337 , (Europe PMC )NA BioGRID DAPK3 Biochemical Activity physical 15001356 , (Europe PMC )NA BioGRID DAXX Affinity Capture-Western, Co-localization, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy, nuclear magnetic resonance, proximity ligation assay, two hybrid association, colocalization, direct interaction, physical, physical association 12482984 , 12954772 , 14557665 , 15339933 , 15364927 , 16845383 , 21134643 , 21482821 , 23038753 , 25241761 , (Europe PMC )0.44, 0.84 BioGRID, IntAct DBN1 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID DCAF1 Reconstituted Complex physical 22184063 , (Europe PMC )NA BioGRID DCAF7 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID DCLRE1C Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID DDB1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID DDX17 anti bait coimmunoprecipitation, pull down physical association 15660129 , (Europe PMC )0.52 IntAct DDX3X Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID DDX5 Affinity Capture-MS, anti bait coimmunoprecipitation, pull down direct interaction, physical, physical association 15660129 , 20818423 , 23443559 , 24219989 , 25144556 , (Europe PMC )0.44, 0.54, 0.66 BioGRID, IntAct, MINT DDX50 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID DGKZ Affinity Capture-Western, Reconstituted Complex physical 23606744 , (Europe PMC )NA BioGRID DHCR24 Affinity Capture-Western physical 15577914 , (Europe PMC )NA BioGRID DHFR Reconstituted Complex physical 18451149 , (Europe PMC )NA BioGRID DHRS4 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID DKK2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID DLEU1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct DLST Affinity Capture-MS, cross-linking study association, physical 29128334 , (Europe PMC )0.35 BioGRID, IntAct DMTF1 Affinity Capture-Western, Reconstituted Complex physical 22331460 , 28406729 , (Europe PMC )NA BioGRID DNAJA1 Affinity Capture-MS, Affinity Capture-Western physical 23443559 , 25144556 , 27775703 , (Europe PMC )NA BioGRID DNAJA2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID DNAJB1 Affinity Capture-Western physical 24361594 , (Europe PMC )NA BioGRID DNAJB6 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID DNAJC7 Phenotypic Enhancement, Synthetic Growth Defect, Two-hybrid genetic, physical 23261415 , (Europe PMC )NA BioGRID DNMT1 Affinity Capture-Western physical 17991895 , 23038753 , (Europe PMC )NA BioGRID DNMT3L Reconstituted Complex physical 24952347 , (Europe PMC )NA BioGRID DOCK7 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID DOT1L Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID DPH1 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID DPP6 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID DROSHA anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical association 19626115 , 24219989 , (Europe PMC )0.68 IntAct, MINT DTL Affinity Capture-Western, Biochemical Activity physical 16861890 , (Europe PMC )NA BioGRID DUSP26 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, phosphatase assay, pull down dephosphorylation reaction, direct interaction, physical association 20562916 , (Europe PMC )0.65 IntAct DVL2 Two-hybrid, barcode fusion genetics two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid physical, physical association 16189514 , 16713569 , 27107012 , (Europe PMC )0.71 BioGRID, IntAct DYNC1I1 anti bait coimmunoprecipitation physical association 16616141 , (Europe PMC )0.40 IntAct, MINT DZIP1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID E4F1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 10644996 , 12446718 , 16652157 , (Europe PMC )NA BioGRID EAF2 barcode fusion genetics two hybrid, validated two hybrid physical association 27107012 , (Europe PMC )0.49 IntAct EBI-16429055 two hybrid array, two hybrid prey pooling approach, validated two hybrid physical association 26871637 , (Europe PMC )0.56 IntAct EBI-1782980 electrophoretic mobility supershift assay physical association 18510931 , (Europe PMC )0.40 IntAct EBI-1799539 chromatin immunoprecipitation assay, electrophoretic mobility shift assay association, direct interaction 18485870 , (Europe PMC )0.52 IntAct EBI-1800051 electrophoretic mobility shift assay, electrophoretic mobility supershift assay association 18485870 , (Europe PMC )0.46 IntAct EBI-2624319 filter binding physical association 20227041 , (Europe PMC )0.40 IntAct EBI-4399559 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, comigration in sds page, pull down association, covalent binding, direct interaction, physical association 17470788 , 17592138 , 18172499 , 18359851 , 18413597 , 18695251 , 19196987 , 19556538 , 19805293 , 20173098 , 21857681 , 22056774 , 24667498 , (Europe PMC )0.97 IntAct EBI-714308 two hybrid pooling approach physical association 16169070 , (Europe PMC )0.37 IntAct EBNA1BP2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ECD Affinity Capture-Western physical 23880345 , (Europe PMC )NA BioGRID ECT2 Affinity Capture-MS physical 22990118 , (Europe PMC )NA BioGRID EEA1 Affinity Capture-MS physical 12665691 , (Europe PMC )NA BioGRID EEF1A1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID EEF2 Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 12891704 , 22653443 , (Europe PMC )0.35 BioGRID, IntAct, MINT EFEMP2 Affinity Capture-Western, Two-hybrid physical 10380882 , (Europe PMC )NA BioGRID EGFR Synthetic Growth Defect, Synthetic Lethality genetic 23284306 , 27438146 , (Europe PMC )NA BioGRID EGLN3 anti tag coimmunoprecipitation association 26972000 , (Europe PMC )0.35 IntAct EGR1 Affinity Capture-Western, Reconstituted Complex, cosedimentation colocalization, physical 11251186 , 14744935 , 15225550 , 21325822 , (Europe PMC )0.35 BioGRID, IntAct, MINT EHMT1 Biochemical Activity physical 20118233 , 20588255 , (Europe PMC )NA BioGRID EHMT2 Biochemical Activity physical 20118233 , (Europe PMC )NA BioGRID EIF2AK2 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 10348343 , 19631745 , (Europe PMC )NA BioGRID EIF2S2 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct EIF4E2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID EIF5B Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID ELAVL1 Affinity Capture-RNA physical 14517280 , (Europe PMC )NA BioGRID ELL Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 10358050 , (Europe PMC )NA BioGRID ELL3 Affinity Capture-Western, Reconstituted Complex, Synthetic Growth Defect genetic, physical 23284306 , 26540344 , (Europe PMC )NA BioGRID ENAH Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ENSG00000019186 chromatin immunoprecipitation assay association 20227041 , (Europe PMC )0.35 IntAct ENSG00000024526 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000026508 chromatin immunoprecipitation assay, electrophoretic mobility supershift assay association, direct interaction 18614011 , (Europe PMC )0.52 IntAct ENSG00000048392 chromatin immunoprecipitation assay association 17719542 , (Europe PMC )0.35 IntAct ENSG00000072518 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000087088 chromatin immunoprecipitation assay association 17906639 , (Europe PMC )0.35 IntAct ENSG00000095203 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000100084 chromatin immunoprecipitation assay association 20227041 , (Europe PMC )0.35 IntAct ENSG00000105327 chromatin immunoprecipitation assay association 17719542 , (Europe PMC )0.35 IntAct ENSG00000105329 chromatin immunoprecipitation assay association 20227041 , (Europe PMC )0.35 IntAct ENSG00000105486 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000106018 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000111412 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000111605 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000112964 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000115129 chromatin immunoprecipitation assay association 17719542 , 18485870 , (Europe PMC )0.53 IntAct ENSG00000115163 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000119147 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000120471 chromatin immunoprecipitation assay association 17719542 , (Europe PMC )0.35 IntAct ENSG00000121152 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000124762 chromatin immunoprecipitation assay association 17719542 , 17906639 , 18614011 , 19249676 , 19410543 , 20228809 , 21317932 , 21423215 , 23870121 , (Europe PMC )0.90 IntAct ENSG00000126549 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000129195 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000131966 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000135679 chromatin immunoprecipitation assay association 17719542 , 18485870 , 20228809 , (Europe PMC )0.64 IntAct ENSG00000137752 electrophoretic mobility shift assay physical association 11278253 , (Europe PMC )0.40 IntAct ENSG00000138759 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000145194 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000145604 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000155090 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000156787 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000159055 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000163743 chromatin immunoprecipitation assay association 18485870 , (Europe PMC )0.35 IntAct ENSG00000167553 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000169679 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000175305 chromatin immunoprecipitation assay association 21741598 , (Europe PMC )0.35 IntAct ENSG00000186260 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000187601 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000204963 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000205560 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct ENSG00000244005 chromatin immunoprecipitation array association 20227041 , (Europe PMC )0.35 IntAct EP300 Affinity Capture-Luminescence, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-fractionation, Co-localization, Phenotypic Suppression, Protein-peptide, Reconstituted Complex, acetylase assay, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, atomic force microscopy, classical fluorescence spectroscopy, coimmunoprecipitation, isothermal titration calorimetry, nuclear magnetic resonance, pull down, x ray scattering acetylation reaction, association, direct interaction, genetic, physical, physical association 10490106 , 10518217 , 10942770 , 11070080 , 11359905 , 11433299 , 11782467 , 11804596 , 11907332 , 12162806 , 12501250 , 12690203 , 12724314 , 14612423 , 14759370 , 15186775 , 15295102 , 15337767 , 15509808 , 15542844 , 15558054 , 15664194 , 15965232 , 16024799 , 16135789 , 16537920 , 16543236 , 16611888 , 16678111 , 16782091 , 16928824 , 16959611 , 17189186 , 17438265 , 17452980 , 17906639 , 17977830 , 18243116 , 18391200 , 18485870 , 18612383 , 19217391 , 19218448 , 19234109 , 19339993 , 19805293 , 20234175 , 21187340 , 21471221 , 22013068 , 22074660 , 22266186 , 22731250 , 23010591 , 23307557 , 23329847 , 23402884 , 23728348 , 23796514 , 23870121 , 23880760 , 24157709 , 24821727 , 25156994 , 25288747 , 25651062 , 25753752 , 25867071 , 26229107 , 26302407 , 26625199 , 27818144 , 9194564 , 9194565 , 9288740 , 9744860 , 9809062 , 9891054 , (Europe PMC )0.40, 0.97 BioGRID, IntAct, MINT EP400 Affinity Capture-Western physical 9194565 , (Europe PMC )NA BioGRID EPG5 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID EPHA3 Reconstituted Complex physical 15355990 , (Europe PMC )NA BioGRID ERBB4 Affinity Capture-Western physical 20858735 , (Europe PMC )NA BioGRID ERCC2 Far Western, Reconstituted Complex physical 7663514 , 8612585 , (Europe PMC )NA BioGRID ERCC3 Affinity Capture-Western, Reconstituted Complex physical 12379483 , 7663514 , 8612585 , (Europe PMC )NA BioGRID ERCC6 Affinity Capture-Western, Reconstituted Complex physical 10882116 , 22032989 , 7663514 , (Europe PMC )NA BioGRID ERCC8 Affinity Capture-Western physical 22032989 , (Europe PMC )NA BioGRID ERH Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct ERN1 Affinity Capture-Western physical 26254280 , (Europe PMC )NA BioGRID ESR1 Affinity Capture-Western, Reconstituted Complex physical 10766163 , 17545634 , 26556313 , (Europe PMC )NA BioGRID ESS2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID ETHE1 Affinity Capture-Western physical 17353187 , (Europe PMC )NA BioGRID ETS1 Affinity Capture-Western physical 14586398 , 18374905 , 24857950 , (Europe PMC )NA BioGRID ETS2 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down direct interaction, physical, physical association 18374905 , 26331536 , 26871468 , (Europe PMC )0.60 BioGRID, IntAct ETV1 Dosage Rescue, Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID EWSR1 Affinity Capture-Western physical 22266186 , (Europe PMC )NA BioGRID EXOSC4 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID EXOSC7 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID EXOSC8 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID FAM111A Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID FAM173A Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct FAU Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID FBL Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID FBXO11 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, enzymatic study, pull down direct interaction, neddylation reaction, physical, physical association 17098746 , (Europe PMC )0.65 BioGRID, IntAct FBXO21 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID FBXO4 Affinity Capture-Western physical 19343786 , (Europe PMC )NA BioGRID FBXO42 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 19509332 , 21127074 , (Europe PMC )NA BioGRID FBXW11 Affinity Capture-MS physical 25515538 , (Europe PMC )NA BioGRID FBXW7 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID FBXW8 Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification association, physical 22653443 , 25609649 , (Europe PMC )0.53 BioGRID, IntAct, MINT FCAMR Two-hybrid, two hybrid physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct FHIT Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID FKBP3 Affinity Capture-Western physical 19166840 , (Europe PMC )NA BioGRID FLNA Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID FOXA3 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXB1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXC1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXG1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXJ3 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXK1 Affinity Capture-MS physical 25609649 , (Europe PMC )NA BioGRID FOXK1 tandem affinity purification association 25609649 , (Europe PMC )0.35 IntAct, MINT FOXK2 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXN1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXO3 Affinity Capture-RNA, Co-localization physical 25241761 , 27886165 , (Europe PMC )NA BioGRID FOXO3 anti tag coimmunoprecipitation, proximity ligation assay physical association 14976264 , 25241761 , (Europe PMC )0.59 IntAct FOXP1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXQ1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FOXS1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FTH1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID FXYD6 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct FZR1 Biochemical Activity physical 10922056 , (Europe PMC )NA BioGRID G3BP1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 17297477 , (Europe PMC )NA BioGRID G3BP2 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 17297477 , (Europe PMC )NA BioGRID GABRG3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID GADD45A Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT GAPDH Affinity Capture-Western physical 18552833 , (Europe PMC )NA BioGRID GFI1 anti tag coimmunoprecipitation physical association 23410974 , (Europe PMC )0.40 IntAct GFPT2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID GIGYF2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID GK2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID GLI1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT GMPS Affinity Capture-Western physical 24462112 , (Europe PMC )NA BioGRID GNB2 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID GNL3 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation physical, physical association 12464630 , 19033382 , (Europe PMC )0.40 BioGRID, IntAct GNL3L Affinity Capture-Western, anti tag coimmunoprecipitation physical, physical association 21132010 , (Europe PMC )0.40 BioGRID, IntAct GOLGA2P5 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID GPATCH8 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID GPR156 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID GPS1 Co-fractionation physical 11285227 , (Europe PMC )NA BioGRID GPS2 Affinity Capture-Western, Reconstituted Complex physical 11486030 , (Europe PMC )NA BioGRID GPSM3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID GPX2 Two-hybrid, two hybrid physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct GRB2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT GRIN2B Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID GRWD1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID GSK3B Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, protein kinase assay, two hybrid phosphorylation reaction, physical, physical association 12048243 , 14744935 , 21900206 , (Europe PMC )0.66 BioGRID, IntAct, MINT GSN Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID GSTM4 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct GTF2H1 Co-crystal Structure, Far Western, Reconstituted Complex, pull down direct interaction, physical 16793543 , 18160537 , 18354501 , 7935417 , 8612585 , (Europe PMC )0.44 BioGRID, IntAct, MINT GTF2H4 Far Western physical 8612585 , (Europe PMC )NA BioGRID GTF2I Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID GTF3C3 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID GTF3C4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID GTPBP4 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID GUCY1A1 Affinity Capture-Western physical 24725084 , (Europe PMC )NA BioGRID GUSBP1 two hybrid pooling approach physical association 16169070 , (Europe PMC )0.37 IntAct H2AFX Affinity Capture-Western physical 16322227 , (Europe PMC )NA BioGRID HABP4 Affinity Capture-Western, Reconstituted Complex physical 16455055 , (Europe PMC )NA BioGRID HADHB Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID HAUS1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID HAUS4 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID HBB Affinity Capture-MS physical 12665691 , (Europe PMC )NA BioGRID HDAC1 Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, proximity ligation assay association, physical, physical association 10521394 , 10777477 , 11099047 , 11313951 , 12426395 , 14976551 , 16107876 , 16697957 , 16959611 , 17827154 , 18765668 , 19011633 , 19303885 , 20075864 , 20633551 , 22266186 , 25241761 , 26539911 , (Europe PMC )0.73 BioGRID, IntAct, MINT HDAC2 Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 14976551 , 17805299 , 17827154 , 20190809 , 20388487 , 21344396 , 22493095 , (Europe PMC )0.35 BioGRID, IntAct HDAC3 anti tag coimmunoprecipitation association 16847267 , (Europe PMC )0.35 IntAct HDAC5 Affinity Capture-MS physical 21081666 , (Europe PMC )NA BioGRID HDAC8 x-ray crystallography direct interaction 17721440 , (Europe PMC )0.44 IntAct, MINT HDAC9 Affinity Capture-Western physical 20947501 , (Europe PMC )NA BioGRID HECTD1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID HECTD3 Two-hybrid physical 23358872 , (Europe PMC )NA BioGRID HECW1 Affinity Capture-Western, Reconstituted Complex physical 18223681 , (Europe PMC )NA BioGRID HECW2 Affinity Capture-Western physical 12890487 , (Europe PMC )NA BioGRID HERC2 Affinity Capture-Western, Reconstituted Complex physical 24722987 , 27259994 , (Europe PMC )NA BioGRID HERC2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT HERC5 Affinity Capture-Western physical 25071020 , (Europe PMC )NA BioGRID HEXIM1 Affinity Capture-Western physical 22948151 , (Europe PMC )NA BioGRID HEY1 Reconstituted Complex physical 27129302 , (Europe PMC )NA BioGRID HIF1A Affinity Capture-Western, Reconstituted Complex physical 10640274 , 11593383 , 12124396 , 12606552 , 27345397 , 9537326 , (Europe PMC )NA BioGRID HINFP Two-hybrid, two hybrid physical, physical association 21516116 , (Europe PMC )0.37 BioGRID, IntAct, MINT HINT3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID HIPK1 Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, two hybrid physical, physical association 12702766 , (Europe PMC )0.51 BioGRID, IntAct HIPK2 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down direct interaction, physical, physical association 11740489 , 11925430 , 15896780 , 16212962 , 17349959 , 21057547 , 25313037 , (Europe PMC )0.71 BioGRID, IntAct, MINT HIPK3 Affinity Capture-MS, Two-hybrid, tandem affinity purification physical, physical association 10961991 , 23602568 , (Europe PMC )0.40 BioGRID, IntAct HMGA1 Affinity Capture-Western physical 20335021 , (Europe PMC )NA BioGRID HMGB1 Affinity Capture-Western, Reconstituted Complex, cross-linking study, far western blotting, isothermal titration calorimetry, molecular sieving, nuclear magnetic resonance direct interaction, physical, physical association 11106654 , 11748221 , 23063560 , 9472015 , (Europe PMC )0.74 BioGRID, IntAct HNF4A Affinity Capture-MS, Reconstituted Complex physical 11818510 , 28514442 , (Europe PMC )NA BioGRID HNRNPA1 Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID HNRNPA2B1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID HNRNPF Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID HNRNPH1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID HNRNPK Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down physical, physical association 21821029 , 23092970 , 25144556 , (Europe PMC )0.52, 0.59 BioGRID, IntAct, MINT HNRNPL Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID HNRNPM Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID HNRNPU Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID HNRNPUL1 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, direct interaction, physical association 15907477 , 22653443 , (Europe PMC )0.70 IntAct, MINT HOMER3 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID HOXA9 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID HPCA Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID HR Affinity Capture-Western physical 27355563 , (Europe PMC )NA BioGRID HRAS Affinity Capture-Western physical 21041410 , (Europe PMC )NA BioGRID HSP90AA1 Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, nuclear magnetic resonance direct interaction, physical 10557093 , 11297531 , 11507088 , 12427754 , 15001357 , 15358769 , 21268072 , 21460846 , 22939624 , 23443559 , (Europe PMC )0.44 BioGRID, IntAct HSP90AB1 Affinity Capture-MS, luminescence based mammalian interactome mapping physical, physical association 22939624 , 23443559 , (Europe PMC )0.40 BioGRID, IntAct HSP90B1 Affinity Capture-Western, Reconstituted Complex physical 25637791 , (Europe PMC )NA BioGRID HSPA1A Affinity Capture-MS, Affinity Capture-Western physical 23443559 , 25144556 , 7954368 , 8729618 , (Europe PMC )NA BioGRID HSPA1B Affinity Capture-MS, Co-localization physical 25144556 , 25241761 , (Europe PMC )NA BioGRID HSPA1L Affinity Capture-MS, Co-localization, anti bait coimmunoprecipitation, proximity ligation assay physical, physical association 17184779 , 23443559 , 25241761 , (Europe PMC )0.59 BioGRID, IntAct, MINT HSPA2 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID HSPA4 Affinity Capture-Western physical 17184779 , 18223694 , 20847049 , 21268072 , 23109422 , 25144556 , (Europe PMC )NA BioGRID HSPA5 Affinity Capture-MS, Affinity Capture-Western physical 17184779 , 23443559 , (Europe PMC )NA BioGRID HSPA5 anti bait coimmunoprecipitation physical association 17184779 , (Europe PMC )0.40 IntAct, MINT HSPA6 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID HSPA8 Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 11297531 , 23443559 , 25144556 , 28215707 , 7954368 , 8729618 , (Europe PMC )NA BioGRID HSPA9 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, direct interaction, physical, physical association 11900485 , 17184779 , 20153329 , 22340593 , 22366412 , 22726440 , 23443559 , 25144556 , (Europe PMC )0.81 BioGRID, IntAct, MINT HSPB1 Affinity Capture-Western, Co-localization, Two-hybrid, anti bait coimmunoprecipitation, proximity ligation assay, two hybrid pooling approach physical, physical association 16169070 , 17184779 , 25241761 , (Europe PMC )0.69 BioGRID, IntAct, MINT HSPD1 anti bait coimmunoprecipitation association 22726440 , (Europe PMC )0.35 IntAct HTT Affinity Capture-Western, Reconstituted Complex, biochemical, pull down physical, physical association 10823891 , (Europe PMC )0.52 BioGRID, IntAct, MINT HUWE1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, pull down physical, physical association 15989956 , 22552282 , (Europe PMC )0.52 BioGRID, IntAct HYAL4 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID HYPK Affinity Capture-MS physical 23272104 , (Europe PMC )NA BioGRID ICK Affinity Capture-MS, tandem affinity purification association, physical 23602568 , (Europe PMC )0.35 BioGRID, IntAct IDH3B Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID IFI16 Affinity Capture-Western, anti bait coimmunoprecipitation, classical fluorescence spectroscopy, confocal microscopy, pull down direct interaction, physical, physical association 11146555 , 21397192 , (Europe PMC )0.49, 0.72 BioGRID, IntAct IGF1R Affinity Capture-Western physical 19165858 , (Europe PMC )NA BioGRID IGF2BP1 Affinity Capture-MS, Affinity Capture-Western physical 20308539 , 23443559 , (Europe PMC )NA BioGRID IGF2BP3 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID IKBKB Biochemical Activity, anti bait coimmunoprecipitation, protein kinase assay phosphorylation reaction, physical, physical association 19196987 , 19883646 , (Europe PMC )0.61 BioGRID, IntAct, MINT IL1A Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID IMP3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ING1 Affinity Capture-Western physical 12208736 , 19085961 , 9440695 , (Europe PMC )NA BioGRID ING2 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 16024799 , 16782091 , (Europe PMC )0.40 BioGRID, IntAct, MINT ING4 Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, coimmunoprecipitation physical, physical association 12750254 , 15251430 , 15882981 , 17954561 , 18775696 , 20053357 , 21177815 , 21454715 , 23967213 , (Europe PMC )0.40 BioGRID, IntAct, MINT ING5 Affinity Capture-Western physical 12750254 , 17954561 , 21177815 , (Europe PMC )NA BioGRID INSIG1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID IP6K2 anti bait coimmunoprecipitation, pull down direct interaction, physical association 21078964 , (Europe PMC )0.60 IntAct IQGAP1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID IRF7 Two-hybrid physical 18307271 , (Europe PMC )NA BioGRID IRS4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID IRX1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ITCH Affinity Capture-Western, anti bait coimmunoprecipitation association, physical 16908849 , 18559494 , 21474069 , (Europe PMC )0.35 BioGRID, IntAct ITPK1 Biochemical Activity physical 12324474 , (Europe PMC )NA BioGRID ITPKC Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID JMJD6 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, hydroxylase assay, pull down association, direct interaction, hydroxylation reaction, physical association 24667498 , (Europe PMC )0.64 IntAct JMJD8 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID JMY anti bait coimmunoprecipitation physical association 10518217 , (Europe PMC )0.40 IntAct JUN anti bait coimmunoprecipitation association 25609649 , (Europe PMC )0.35 IntAct, MINT KAT2A Affinity Capture-Western physical 18250150 , (Europe PMC )NA BioGRID KAT2B Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid physical 10490106 , 12068014 , 12501250 , 14614455 , 15965232 , 16537920 , 16678111 , 17189186 , 17977830 , 19680552 , 20589832 , 9744860 , 9891054 , (Europe PMC )NA BioGRID KAT2B anti bait coimmunoprecipitation association 16959611 , (Europe PMC )0.35 IntAct KAT5 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, anti tag coimmunoprecipitation, chromatin immunoprecipitation assay association, physical, physical association 15310756 , 16601686 , 17189186 , 17704809 , 18280244 , 18485870 , 23677994 , (Europe PMC )0.50 BioGRID, IntAct KAT6A Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 19001415 , 23431171 , (Europe PMC )NA BioGRID KAT7 Affinity Capture-Western, Reconstituted Complex physical 17954561 , (Europe PMC )NA BioGRID KAT8 Biochemical Activity, Reconstituted Complex, anti tag coimmunoprecipitation, pull down association, physical, physical association 15960975 , 16601686 , 17189187 , 19854137 , (Europe PMC )0.56 BioGRID, IntAct, MINT KCTD17 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID KDM1A Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, demethylase assay, pull down association, demethylation reaction, direct interaction, physical, physical association 17805299 , 18573881 , 22653443 , (Europe PMC )0.35, 0.66 BioGRID, IntAct, MINT KDM4A pull down association 23871696 , (Europe PMC )0.35 IntAct KDM4D Affinity Capture-Western, Two-hybrid physical 22514644 , (Europe PMC )NA BioGRID KDM6A Affinity Capture-Western physical 24078252 , (Europe PMC )NA BioGRID KDR Synthetic Lethality genetic 27438146 , (Europe PMC )NA BioGRID KHDRBS1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT KIAA0087 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct KIF2A Dosage Rescue genetic 20506231 , (Europe PMC )NA BioGRID KIT Positive Genetic genetic 28319113 , (Europe PMC )NA BioGRID KLF5 Affinity Capture-Western physical 16595680 , (Europe PMC )NA BioGRID KLHL40 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID KLRF1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID KMT2A Affinity Capture-MS, Reconstituted Complex, pull down association, physical 15960975 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct KMT2C anti tag coimmunoprecipitation association 19433796 , (Europe PMC )0.35 IntAct KMT2E Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 21423215 , (Europe PMC )0.52 BioGRID, IntAct KMT5A Biochemical Activity physical 17707234 , (Europe PMC )NA BioGRID KPNA4 Affinity Capture-Western, Reconstituted Complex physical 19927155 , (Europe PMC )NA BioGRID KPNB1 Affinity Capture-Western, Reconstituted Complex physical 11297531 , (Europe PMC )NA BioGRID KSR1 anti tag coimmunoprecipitation association 27086506 , (Europe PMC )0.35 IntAct KSR2 anti tag coimmunoprecipitation association 27086506 , (Europe PMC )0.35 IntAct L3MBTL1 Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex physical 20870725 , (Europe PMC )NA BioGRID LAMA4 Co-localization, Two-hybrid, proximity ligation assay, two hybrid pooling approach physical, physical association 16169070 , 25241761 , (Europe PMC )0.57 BioGRID, IntAct LAMTOR5 Affinity Capture-Western, Reconstituted Complex physical 26229107 , (Europe PMC )NA BioGRID LAP3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID LAPTM5 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID LGI4 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID LIMA1 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID LINC01194 Affinity Capture-Western physical 14612521 , (Europe PMC )NA BioGRID LMNA Affinity Capture-MS, pull down association, physical 25144556 , 29568061 , (Europe PMC )0.35 BioGRID, IntAct LRPPRC Affinity Capture-MS, Affinity Capture-Western physical 20308539 , 23443559 , (Europe PMC )NA BioGRID LRRK2 Affinity Capture-Western, Biochemical Activity, tandem affinity purification association, physical 24725412 , 26384650 , (Europe PMC )0.35 BioGRID, IntAct LSM14A Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID LY6G5B Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID LYN Affinity Capture-Western physical 12642697 , (Europe PMC )NA BioGRID LYZ Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID MAD2L1BP Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct MAFK Affinity Capture-Western physical 19011633 , (Europe PMC )NA BioGRID MAGEA2 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, ubiquitinase assay association, direct interaction, physical, physical association, ubiquitination reaction 16847267 , 20864041 , 26468294 , (Europe PMC )0.73 BioGRID, IntAct MAGEB18 Two-hybrid, two hybrid array, two hybrid pooling approach physical, physical association 16189514 , 16713569 , (Europe PMC )0.55 BioGRID, IntAct MAGEC2 pull down, ubiquitinase assay association, physical association, ubiquitination reaction 20864041 , (Europe PMC )0.59 IntAct MAGED2 Affinity Capture-MS, Affinity Capture-Western physical 17912449 , 23443559 , (Europe PMC )NA BioGRID MAP1B anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy colocalization, physical association 18656471 , (Europe PMC )0.56 IntAct, MINT MAP1LC3B Affinity Capture-Western physical 25144556 , (Europe PMC )NA BioGRID MAP3K1 Affinity Capture-Western, Reconstituted Complex physical 20923779 , 26018553 , (Europe PMC )NA BioGRID MAP9 Affinity Capture-Western, Two-hybrid physical 22672907 , (Europe PMC )NA BioGRID MAPK1 Affinity Capture-MS, Affinity Capture-Western, Co-localization, PCA, proximity ligation assay physical, physical association 10958792 , 21147777 , 21675959 , 23443559 , 25241761 , (Europe PMC )0.40 BioGRID, IntAct MAPK10 Affinity Capture-Western physical 9393873 , (Europe PMC )NA BioGRID MAPK11 protein kinase assay phosphorylation reaction 17254968 , (Europe PMC )0.44 IntAct MAPK14 Affinity Capture-Western, Biochemical Activity, PCA physical 10581258 , 15642743 , 17172861 , 20213747 , 21050851 , 21675959 , (Europe PMC )NA BioGRID MAPK3 Affinity Capture-Western physical 10958792 , 21147777 , 21187340 , (Europe PMC )NA BioGRID MAPK7 Affinity Capture-Western physical 22869143 , (Europe PMC )NA BioGRID MAPK8 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation physical, physical association 11108663 , 12514174 , 15538975 , 15580310 , 18813780 , 19651615 , 9393873 , 9724739 , 9732264 , (Europe PMC )0.40 BioGRID, IntAct, MINT MAPK9 Affinity Capture-Western, Biochemical Activity physical 12384512 , 22366412 , 9393873 , (Europe PMC )NA BioGRID MAPKAPK5 Biochemical Activity, protein kinase assay phosphorylation reaction, physical 17254968 , (Europe PMC )0.44 BioGRID, IntAct MCL1 Affinity Capture-Western, Protein-peptide physical 24491548 , 27818144 , (Europe PMC )NA BioGRID MCM8 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID MDC1 Affinity Capture-Western physical 14519663 , (Europe PMC )NA BioGRID MDH1 Affinity Capture-Western, Reconstituted Complex physical 19229245 , (Europe PMC )NA BioGRID MDM2 Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-RNA, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-fractionation, Co-localization, FRET, Far Western, PCA, Phenotypic Suppression, Protein-RNA, Protein-peptide, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, chromatin immunoprecipitation assay, classical fluorescence spectroscopy, cosedimentation in solution, enzyme linked immunosorbent assay, fluorescence polarization spectroscopy, isothermal titration calorimetry, molecular sieving, nuclear magnetic resonance, peptide array, proximity ligation assay, pull down, surface plasmon resonance, two hybrid, ubiquitinase assay, x-ray crystallography association, direct interaction, genetic, physical, physical association, ubiquitination reaction 10196247 , 10202144 , 10347217 , 10435614 , 10488081 , 10561590 , 10562557 , 10640350 , 10681559 , 10722742 , 10766163 , 10827196 , 10889512 , 10980696 , 11046142 , 11070080 , 11094089 , 11112690 , 11178989 , 11284721 , 11285227 , 11351297 , 11384992 , 11431470 , 11486026 , 11562347 , 11572869 , 11597128 , 11697899 , 11709713 , 11713287 , 11713288 , 11714701 , 11744695 , 11839577 , 11925449 , 12167711 , 12208736 , 12381304 , 12426395 , 12552135 , 12612087 , 12620407 , 12690203 , 12842086 , 12897156 , 12915590 , 12944468 , 14499615 , 14517261 , 14559824 , 14596917 , 14612427 , 14671306 , 14702041 , 14704432 , 14741215 , 15001357 , 15013777 , 15053879 , 15058298 , 15064742 , 15094782 , 15122315 , 15144954 , 15154850 , 15210108 , 15242646 , 15247280 , 15280377 , 15295102 , 15308643 , 15313915 , 15358376 , 15542844 , 15550400 , 15558054 , 15604276 , 15824742 , 15848166 , 15908921 , 15933712 , 15950904 , 16023600 , 16055726 , 16107876 , 1614537 , 16152627 , 16159876 , 16173922 , 16201274 , 16212962 , 16215989 , 16331255 , 16338390 , 16414131 , 16432196 , 16547496 , 16579792 , 16595680 , 16624812 , 16678796 , 16751805 , 16845383 , 16857591 , 16861890 , 16866370 , 16870621 , 16905769 , 16964247 , 17056014 , 17080083 , 17098746 , 17116689 , 17139261 , 17159902 , 17268548 , 17290220 , 17297477 , 17301054 , 17302414 , 17310983 , 17318220 , 17347673 , 17363365 , 17369817 , 17380154 , 17426254 , 17438265 , 17470788 , 17525743 , 17591690 , 17616658 , 17666403 , 17848574 , 17875722 , 17908790 , 17936559 , 17989425 , 18061646 , 18172499 , 18223694 , 18234963 , 18309296 , 18316739 , 18332869 , 18467333 , 18485870 , 18541670 , 18566590 , 18604177 , 18665269 , 18813780 , 18815136 , 18981217 , 19033382 , 19071110 , 19081178 , 19085961 , 19098711 , 19106616 , 19153082 , 19160491 , 19166840 , 19188367 , 19223463 , 19234109 , 19255450 , 19303885 , 19305137 , 19332559 , 19357310 , 19411066 , 19411846 , 19483087 , 19568783 , 19590512 , 19597489 , 19656744 , 19805293 , 19816404 , 19837670 , 19857530 , 19941302 , 20047188 , 20080206 , 20124408 , 20173098 , 20174603 , 20234175 , 20235143 , 20395212 , 20479273 , 20484049 , 20542919 , 20570896 , 20588255 , 20591429 , 20591651 , 20639885 , 20657550 , 20659896 , 20660730 , 20694676 , 20705607 , 20708156 , 20837658 , 20847049 , 20959462 , 20962272 , 21060154 , 21071676 , 21075307 , 21084285 , 21084564 , 21088494 , 21098709 , 21132010 , 21149449 , 21170087 , 21261729 , 21268072 , 21316347 , 21317885 , 21454483 , 21465263 , 21471462 , 21478269 , 21561866 , 21572037 , 21584881 , 21726810 , 21750659 , 21857681 , 21887275 , 21925390 , 21965653 , 21986495 , 21988832 , 22032989 , 22083959 , 22084066 , 22085928 , 22103682 , 22124327 , 22157679 , 22227409 , 22262183 , 22266850 , 22266868 , 22301280 , 22318540 , 22331460 , 22366412 , 22374672 , 22389628 , 22391559 , 22411991 , 22444248 , 22474335 , 22487680 , 22510990 , 22525275 , 22575647 , 22588298 , 22653443 , 22659184 , 22737255 , 22807444 , 22819825 , 22912717 , 22914926 , 22916255 , 22920093 , 22948151 , 22975381 , 23134341 , 23150668 , 23169665 , 23201157 , 23246961 , 23252402 , 23261415 , 23318437 , 23370271 , 23402884 , 23443559 , 23483203 , 23572512 , 23609977 , 23671280 , 23728348 , 23776060 , 23776465 , 23802716 , 23826318 , 23880345 , 23946421 , 24127580 , 24200963 , 24207125 , 24240685 , 24314634 , 24361594 , 24413661 , 24462112 , 24488098 , 24567357 , 24621507 , 24643130 , 24659749 , 24667498 , 24842904 , 24926618 , 24980433 , 24998844 , 25103245 , 25156994 , 25168242 , 25241761 , 25277184 , 25283148 , 25312347 , 25313037 , 25362358 , 25384516 , 25417702 , 25464845 , 25512388 , 25543083 , 25609649 , 25624478 , 25637791 , 25739118 , 25954860 , 26001071 , 26186194 , 26203195 , 26238070 , 26350565 , 26475964 , 26540344 , 26556313 , 26578655 , 26673821 , 26720344 , 26876197 , 26882543 , 26883110 , 26908445 , 27031960 , 27106262 , 27129163 , 27215386 , 27282385 , 27308622 , 27336364 , 27462439 , 27543608 , 27807478 , 27811966 , 27856536 , 27886165 , 27893708 , 28082682 , 28223335 , 28362432 , 28394340 , 28514442 , 28542145 , 28549433 , 28553961 , 28605833 , 7686617 , 7689721 , 8058315 , 8875929 , 9131587 , 9223638 , 9271120 , 9278461 , 9363941 , 9450543 , 9529249 , 9582019 , 9724739 , 9809062 , 9824166 , (Europe PMC )0.99 BioGRID, IntAct, MINT MDM4 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Co-localization, PCA, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, enzyme linked immunosorbent assay, fluorescence microscopy, fluorescence polarization spectroscopy, isothermal titration calorimetry, nuclear magnetic resonance, pull down, tandem affinity purification, ubiquitinase assay association, colocalization, direct interaction, physical, physical association, ubiquitination reaction 10075736 , 10608892 , 10827196 , 11223036 , 12370303 , 12393902 , 12874296 , 15604276 , 15916963 , 16024788 , 16227609 , 17080083 , 17301054 , 17875722 , 18316739 , 18485870 , 18677113 , 19075013 , 19153082 , 19255450 , 19305137 , 19432880 , 19521340 , 20174603 , 20515689 , 20705607 , 20724842 , 21075307 , 21088494 , 21925390 , 21965653 , 22266850 , 22374672 , 22807444 , 23028042 , 23671280 , 23946421 , 24127580 , 24445145 , 24659749 , 24667498 , 25464845 , 25609649 , 25825738 , 26148237 , 26186194 , 26876197 , 27114532 , 28487147 , 28514442 , 9226370 , (Europe PMC )0.96 BioGRID, IntAct, MINT MED1 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down physical, physical association 11118038 , 15848166 , 9444950 , (Europe PMC )0.52 BioGRID, IntAct, MINT MED17 Reconstituted Complex physical 10198638 , (Europe PMC )NA BioGRID MED21 Reconstituted Complex physical 10024883 , (Europe PMC )NA BioGRID MED22 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID MED8 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID MEN1 Reconstituted Complex, pull down association, physical 15960975 , (Europe PMC )0.35 BioGRID, IntAct MFAP4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MFSD12 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID MIF Affinity Capture-Western physical 18815136 , (Europe PMC )NA BioGRID MKRN1 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down direct interaction, physical, physical association 19536131 , (Europe PMC )0.60 BioGRID, IntAct, MINT MNAT1 Affinity Capture-Western, Reconstituted Complex physical 9372954 , (Europe PMC )NA BioGRID MOGS Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MORN2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID MOV10 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT MPDZ anti tag coimmunoprecipitation association, physical association 22653443 , (Europe PMC )0.50 IntAct, MINT MPHOSPH6 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct MPP5 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT MRPL24 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPL38 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPL39 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPL41 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS14 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS18B Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS22 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT MRPS23 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS25 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS27 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS28 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS5 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MRPS9 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID MSH2 Affinity Capture-Western physical 12101417 , 15064730 , (Europe PMC )NA BioGRID MSH6 Affinity Capture-Western physical 15064730 , (Europe PMC )NA BioGRID MSI2 Affinity Capture-Western physical 28223335 , (Europe PMC )NA BioGRID MSL2 Affinity Capture-Western, Reconstituted Complex physical 19033443 , (Europe PMC )NA BioGRID MT1A anti bait coimmunoprecipitation, pull down direct interaction, physical association 16442532 , (Europe PMC )0.54 IntAct, MINT MTA1 Affinity Capture-Western, Co-localization, Reconstituted Complex physical 12920132 , 17914590 , 19837670 , 20071335 , (Europe PMC )NA BioGRID MTA2 Affinity Capture-Western, Reconstituted Complex physical 11099047 , 12920132 , (Europe PMC )NA BioGRID MTHFSD Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID MTOR Affinity Capture-Western, Synthetic Lethality, anti bait coimmunoprecipitation association, genetic, physical 19619545 , 27438146 , (Europe PMC )0.35 BioGRID, IntAct, MINT MUC1 Affinity Capture-Western, Co-localization, Reconstituted Complex physical 15710329 , (Europe PMC )NA BioGRID MUL1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 21597459 , (Europe PMC )NA BioGRID MVP Two-hybrid physical 24722188 , (Europe PMC )NA BioGRID MYBBP1A Reconstituted Complex physical 21471221 , (Europe PMC )NA BioGRID MYBPC1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID MYC Affinity Capture-MS, tandem affinity purification association, physical 21150319 , (Europe PMC )0.35 BioGRID, IntAct MYH9 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID MYL9 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID MYLK Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID MYO1C Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID MYO6 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID MYOT Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID MZT2B Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID NABP1 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct NABP2 Affinity Capture-Western, Reconstituted Complex physical 23184057 , (Europe PMC )NA BioGRID NAP1L1 pull down direct interaction 14966293 , (Europe PMC )0.44 IntAct, MINT NAT10 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 26882543 , (Europe PMC )NA BioGRID NCL Affinity Capture-Western, Far Western, Reconstituted Complex, far western blotting, pull down direct interaction, physical 12138209 , 22103682 , 26238070 , (Europe PMC )0.56 BioGRID, IntAct, MINT NCOA1 Reconstituted Complex, Two-hybrid physical 10551785 , (Europe PMC )NA BioGRID NCOA2 Reconstituted Complex, display technology physical, physical association 20195357 , (Europe PMC )0.40 BioGRID, IntAct NCOA3 Reconstituted Complex physical 10551785 , (Europe PMC )NA BioGRID NCOA6 anti tag coimmunoprecipitation association 19433796 , (Europe PMC )0.35 IntAct NCOR1 Affinity Capture-Western, Co-localization physical 19011633 , 24157709 , (Europe PMC )NA BioGRID NCOR2 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, competition binding, pull down direct interaction, physical association 24449765 , (Europe PMC )0.65 IntAct, MINT NDN Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 10347180 , 18753379 , 23785149 , 24722188 , (Europe PMC )NA BioGRID NDRG4 Affinity Capture-Western physical 26053091 , (Europe PMC )NA BioGRID NEDD8 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT NEIL3 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct NELFCD Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID NEURL4 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT NEUROG2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID NFATC1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT NFKBIA Affinity Capture-Western, Two-hybrid physical 11799106 , (Europe PMC )NA BioGRID NFYA Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, imaging technique association, colocalization, physical, physical association 15831478 , 16959611 , 23908595 , (Europe PMC )0.54 BioGRID, IntAct NFYB Affinity Capture-Western, anti bait coimmunoprecipitation association, physical, physical association 15831478 , 16959611 , 23734815 , (Europe PMC )0.56 BioGRID, IntAct NGFR Affinity Capture-Western, Reconstituted Complex physical 27282385 , (Europe PMC )NA BioGRID NIN Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct NINL Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct NLK Affinity Capture-Western, Phenotypic Enhancement, Reconstituted Complex genetic, physical 24926618 , (Europe PMC )NA BioGRID NME4 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID NMT1 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 16530191 , (Europe PMC )0.40 BioGRID, IntAct, MINT NMT2 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 16530191 , (Europe PMC )0.40 BioGRID, IntAct, MINT NOC2L Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, tandem affinity purification association, direct interaction, physical, physical association 16322561 , 20959462 , (Europe PMC )0.63 BioGRID, IntAct NOL3 anti bait coimmunoprecipitation direct interaction, physical association 18087040 , (Europe PMC )0.54 IntAct NOP53 Affinity Capture-Western, Reconstituted Complex physical 22522597 , (Europe PMC )NA BioGRID NOTCH4 Affinity Capture-Western physical 21402876 , (Europe PMC )NA BioGRID NPAS3 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT NPIPB13 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID NPM1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, coimmunoprecipitation, cross-linking study, surface plasmon resonance association, direct interaction, physical, physical association 12080348 , 15144954 , 15964625 , 16376884 , 16740634 , 23443559 , (Europe PMC )0.35, 0.56, 0.68 BioGRID, IntAct, MINT NPRL3 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID NQO1 Affinity Capture-Western physical 14634213 , 26078718 , 26540344 , (Europe PMC )NA BioGRID NR0B2 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 22575647 , 22737255 , (Europe PMC )0.52 BioGRID, IntAct, MINT NR1I2 Affinity Capture-MS, Affinity Capture-Western physical 23536728 , (Europe PMC )NA BioGRID NR3C1 Affinity Capture-Western, Reconstituted Complex physical 11080152 , 11562347 , (Europe PMC )NA BioGRID NR4A1 Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down, two hybrid array physical, physical association 17139261 , (Europe PMC )0.58 BioGRID, IntAct, MINT NRDC anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical association 22653443 , (Europe PMC )0.58 IntAct, MINT NT5C2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT NT5C3A Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID NUAK1 anti bait coimmunoprecipitation, chromatin immunoprecipitation assay, protein kinase assay association, phosphorylation reaction, physical association 21317932 , (Europe PMC )0.59 IntAct NUB1 Affinity Capture-Western physical 20101219 , (Europe PMC )NA BioGRID NUDT16L1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT NUMB Affinity Capture-Western physical 18172499 , 22157679 , 23881403 , 27106262 , 28223335 , (Europe PMC )NA BioGRID NUMB anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, direct interaction 18172499 , (Europe PMC )0.63 IntAct OBSL1 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, tandem affinity purification association, physical 22653443 , 23443559 , 24711643 , 25609649 , (Europe PMC )0.53 BioGRID, IntAct, MINT OFD1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct OLA1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT OLIG2 Phenotypic Suppression genetic 21397859 , (Europe PMC )NA BioGRID OTUB1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, direct interaction, physical, physical association 22124327 , 24403071 , 27561390 , (Europe PMC )0.63 BioGRID, IntAct, MINT OTUD1 Affinity Capture-Western physical 28216291 , (Europe PMC )NA BioGRID OTUD5 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation physical, physical association 19615732 , 24143256 , 25499082 , (Europe PMC )0.40 BioGRID, IntAct PABPC1 Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID PACRG Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PADI1 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct PADI4 Affinity Capture-Western, Co-localization, Reconstituted Complex physical 18505818 , 20190809 , (Europe PMC )NA BioGRID PAFAH1B3 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct PAGR1 pull down physical association 19039327 , (Europe PMC )0.40 IntAct, MINT PAN2 Affinity Capture-MS physical 23398456 , (Europe PMC )NA BioGRID PARD3 anti tag coimmunoprecipitation association, physical association 22653443 , (Europe PMC )0.50 IntAct, MINT PARK7 Affinity Capture-Western physical 18042550 , 22683601 , (Europe PMC )NA BioGRID PARP1 Affinity Capture-Western, Far Western, Reconstituted Complex, anti bait coimmunoprecipitation, coimmunoprecipitation, pull down association, direct interaction, physical, physical association 12898523 , 14627987 , 15044383 , 9312059 , 9565608 , (Europe PMC )0.75 BioGRID, IntAct, MINT PATZ1 Affinity Capture-Western, Reconstituted Complex physical 24336083 , 25755280 , (Europe PMC )NA BioGRID PAXIP1 anti tag coimmunoprecipitation association 19433796 , (Europe PMC )0.35 IntAct PBK anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, two hybrid physical association 17482142 , 20622899 , (Europe PMC )0.71 IntAct PCBP1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PCDHA4 Two-hybrid physical 16169070 , (Europe PMC )NA BioGRID PCDHA4 two hybrid pooling approach physical association 16169070 , (Europe PMC )0.37 IntAct PCMT1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PCNA Affinity Capture-Western, Co-localization physical 16861890 , 27407148 , (Europe PMC )NA BioGRID PDCD5 Affinity Capture-Western, Co-localization, Reconstituted Complex physical 22914926 , 25499082 , (Europe PMC )NA BioGRID PDCD6 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PDHA1 Affinity Capture-MS, cross-linking study association, physical 29128334 , (Europe PMC )0.35 BioGRID, IntAct PDIA5 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PDLIM7 Affinity Capture-Western, Reconstituted Complex physical 21060154 , (Europe PMC )NA BioGRID PER2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 25103245 , 27834218 , (Europe PMC )NA BioGRID PES1 Affinity Capture-MS physical 25609649 , (Europe PMC )NA BioGRID PES1 tandem affinity purification association 25609649 , (Europe PMC )0.35 IntAct, MINT PHB Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy, fluorescence microscopy colocalization, physical, physical association 14500729 , 16319068 , 20134482 , 24380853 , (Europe PMC )0.62 BioGRID, IntAct, MINT PHC3 tandem affinity purification association 27705803 , (Europe PMC )0.35 IntAct PHF1 Affinity Capture-MS, Affinity Capture-Western, tandem affinity purification association, physical 18385154 , 23150668 , 27705803 , (Europe PMC )0.35 BioGRID, IntAct PHF20 Affinity Capture-Western physical 22864287 , (Europe PMC )NA BioGRID PHKA2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PHKB Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PHKG2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PHYH Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PIAS1 Biochemical Activity, Co-localization, Reconstituted Complex, Two-hybrid, proximity ligation assay, pull down direct interaction, physical, physical association 10380882 , 11583632 , 11867732 , 15133049 , 20805487 , 25241761 , (Europe PMC )0.61 BioGRID, IntAct PIAS2 Biochemical Activity, Co-localization, Reconstituted Complex, Two-hybrid, proximity ligation assay, two hybrid physical, physical association 11867732 , 18624398 , 19339993 , 25241761 , (Europe PMC )0.57 BioGRID, IntAct PIAS4 Two-hybrid, anti bait coimmunoprecipitation, two hybrid physical, physical association 11388671 , 15383276 , (Europe PMC )0.51 BioGRID, IntAct PIN1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, chromatin immunoprecipitation assay, coimmunoprecipitation, pull down, two hybrid association, physical, physical association 12388558 , 12397362 , 17906639 , 21741598 , 21900206 , (Europe PMC )0.85 BioGRID, IntAct, MINT PIWIL1 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID PKIA Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PLAC8 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PLAGL1 Phenotypic Enhancement, Reconstituted Complex genetic, physical 11360197 , (Europe PMC )NA BioGRID PLCG2 Two-hybrid, two hybrid array, validated two hybrid physical, physical association 25814554 , (Europe PMC )0.49 BioGRID, IntAct PLK1 Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay, two hybrid association, phosphorylation reaction, physical, physical association 16753148 , 19833129 , 22653443 , (Europe PMC )0.74 BioGRID, IntAct, MINT PLK3 Affinity Capture-Western, Biochemical Activity physical 11551930 , 12242661 , (Europe PMC )NA BioGRID PLOD3 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT PML Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy, imaging technique, proximity ligation assay association, colocalization, physical, physical association 11025664 , 11080164 , 12006491 , 12915590 , 14976551 , 15375079 , 16007146 , 20972456 , 21057547 , 22869143 , 25241761 , (Europe PMC )0.49, 0.72 BioGRID, IntAct PNP Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct POLA1 Affinity Capture-Western physical 11917009 , (Europe PMC )NA BioGRID POLD3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID POLDIP2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID POLI Affinity Capture-Western, Co-localization physical 27407148 , (Europe PMC )NA BioGRID POLR1D Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID POLRMT Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT PPA1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct PPARGC1A Affinity Capture-Western, Reconstituted Complex physical 22099309 , (Europe PMC )NA BioGRID PPFIBP1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PPIF anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down direct interaction, physical association 22726440 , (Europe PMC )0.64 IntAct PPM1G anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT PPP1CA Two-hybrid, two hybrid physical, physical association 15231748 , (Europe PMC )0.37 BioGRID, IntAct, MINT PPP1CC Affinity Capture-Western, anti bait coimmunoprecipitation, antibody array physical, physical association 17274640 , (Europe PMC )0.52 BioGRID, IntAct PPP1R12A Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID PPP1R13B Affinity Capture-Western, Synthetic Growth Defect, anti bait coimmunoprecipitation association, genetic, physical 21513714 , 23284306 , (Europe PMC )0.35 BioGRID, IntAct, MINT PPP1R13L Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, fluorescence microscopy, pull down, solid phase assay association, colocalization, direct interaction, physical, physical association 12524540 , 17906639 , 18275817 , 20840860 , 21513714 , 23443559 , 23623661 , (Europe PMC )0.81 BioGRID, IntAct, MINT PPP2R1A Affinity Capture-MS, Co-localization, anti bait coimmunoprecipitation, proximity ligation assay, pull down physical, physical association 12665691 , 17245430 , 25241761 , (Europe PMC )0.66 BioGRID, IntAct, MINT PPP2R2A anti bait coimmunoprecipitation physical association 17245430 , (Europe PMC )0.40 IntAct, MINT PPP2R5C Co-localization, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, proximity ligation assay association, physical, physical association 17245430 , 21460856 , 25241761 , (Europe PMC )0.35, 0.69 BioGRID, IntAct, MINT PPP3CA Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PPP3R1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PPP4C Reconstituted Complex physical 9837938 , (Europe PMC )NA BioGRID PRAM1 Affinity Capture-Western physical 14976551 , (Europe PMC )NA BioGRID PRDM2 Affinity Capture-Western physical 20594067 , (Europe PMC )NA BioGRID PRKAB2 barcode fusion genetics two hybrid, validated two hybrid physical association 27107012 , (Europe PMC )0.49 IntAct PRKCD Affinity Capture-Western, anti bait coimmunoprecipitation, protein kinase assay, pull down phosphorylation reaction, physical, physical association 16314418 , 16377624 , (Europe PMC )0.60 BioGRID, IntAct PRKD1 Biochemical Activity physical 12628923 , (Europe PMC )NA BioGRID PRKDC Affinity Capture-Western, Biochemical Activity, Protein-peptide physical 10608806 , 10713094 , 12756247 , 19918261 , 25362358 , 9363941 , 9679063 , 9744860 , (Europe PMC )NA BioGRID PRKN Biochemical Activity, Reconstituted Complex physical 28395174 , (Europe PMC )NA BioGRID PRMT1 Reconstituted Complex physical 15186775 , (Europe PMC )NA BioGRID PRMT3 Affinity Capture-Western physical 21942715 , (Europe PMC )NA BioGRID PRMT5 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID PRPF6 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PRRC2A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PRRC2C Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PSD3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PSMB3 Biochemical Activity physical 20080206 , (Europe PMC )NA BioGRID PSMC1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT PSMC3 Affinity Capture-Western physical 20479273 , (Europe PMC )NA BioGRID PSMC5 Affinity Capture-Western, Reconstituted Complex physical 17224908 , 20479273 , (Europe PMC )NA BioGRID PSMD10 Affinity Capture-Western physical 16023600 , (Europe PMC )NA BioGRID PSMD11 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct PSMD2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT PSMD4 Affinity Capture-Western physical 20479273 , (Europe PMC )NA BioGRID PSMD5 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT PSMD6 Affinity Capture-Western physical 24258024 , (Europe PMC )NA BioGRID PSME3 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, physical, physical association 18309296 , 21084564 , (Europe PMC )0.58 BioGRID, IntAct, MINT PTBP3 anti bait coimmunoprecipitation association 22575643 , (Europe PMC )0.35 IntAct, MINT PTCD3 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID PTEN Affinity Capture-Western, Reconstituted Complex physical 12620407 , 14559824 , 18339852 , 24141722 , (Europe PMC )NA BioGRID PTGS2 Affinity Capture-Western, Co-purification, Reconstituted Complex physical 11687965 , 15707991 , 16928824 , 19465063 , 21187340 , (Europe PMC )NA BioGRID PTK2 Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy, proximity ligation assay, pull down colocalization, direct interaction, physical, physical association 15855171 , 18206965 , 19857493 , 25241761 , (Europe PMC )0.76 BioGRID, IntAct, MINT PTTG1 Affinity Capture-Western, Reconstituted Complex physical 12355087 , 19117984 , (Europe PMC )NA BioGRID PTTG1IP Affinity Capture-Western, Reconstituted Complex, Synthetic Growth Defect genetic, physical 23284306 , 24506068 , 25408419 , (Europe PMC )NA BioGRID PTX3 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PURG Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID PYCR3 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT RAB4A Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct RAB7A Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID RABGAP1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT RABL6 Affinity Capture-Western physical 23572512 , (Europe PMC )NA BioGRID RAD23A Affinity Capture-Western physical 15064742 , 16105547 , (Europe PMC )NA BioGRID RAD51 Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, coimmunoprecipitation physical, physical association 14636569 , 15064730 , 16983346 , 26140185 , 8617246 , 9380510 , (Europe PMC )0.40 BioGRID, IntAct RAE1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RANBP2 Biochemical Activity physical 22194619 , (Europe PMC )NA BioGRID RANBP9 Two-hybrid, anti tag coimmunoprecipitation association, physical 18307271 , 22653443 , (Europe PMC )0.35 BioGRID, IntAct, MINT RAP1B Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT RASGRF1 anti bait coimmunoprecipitation physical association 16753148 , (Europe PMC )0.40 IntAct, MINT RAVER1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RB1 Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 20871633 , 8083962 , (Europe PMC )0.35 BioGRID, IntAct RB1CC1 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 20614030 , 21775823 , (Europe PMC )0.40 BioGRID, IntAct RBBP4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RBBP5 Affinity Capture-Western, Reconstituted Complex, Synthetic Growth Defect, anti tag coimmunoprecipitation, pull down association, genetic, physical 15960975 , 19433796 , 23284306 , 23870121 , (Europe PMC )0.69 BioGRID, IntAct RBBP6 Affinity Capture-Western, Reconstituted Complex physical 9010216 , (Europe PMC )NA BioGRID RBBP7 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RBM3 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RBM39 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RBPJ Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, microscale thermophoresis direct interaction, physical, physical association 26302407 , (Europe PMC )0.65 BioGRID, IntAct RBX1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT RCC1 Two-hybrid, two hybrid physical, physical association 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT RCHY1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, imaging technique, nuclear magnetic resonance, pull down, two hybrid colocalization, direct interaction, physical, physical association 12654245 , 17568776 , 19043414 , 19483087 , 20452352 , 21084285 , 21791603 , 21988832 , 24367557 , 25116336 , (Europe PMC )0.85 BioGRID, IntAct, MINT RCN2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RDH13 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RECQL5 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID RELA Affinity Capture-Western physical 17434128 , (Europe PMC )NA BioGRID RETNLB Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID REV1 Affinity Capture-Western physical 25614517 , (Europe PMC )NA BioGRID RFC1 Affinity Capture-Western physical 12509469 , (Europe PMC )NA BioGRID RFC3 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RFC4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RFFL Affinity Capture-Western physical 17121812 , 18382127 , (Europe PMC )NA BioGRID RFWD2 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, experimental interaction detection, pull down association, direct interaction, physical association, ubiquitination reaction 15103385 , 21625211 , (Europe PMC )0.72 IntAct, MINT RFWD3 Affinity Capture-Western, Reconstituted Complex physical 20173098 , (Europe PMC )NA BioGRID RFWD3 anti bait coimmunoprecipitation, pull down association, direct interaction, physical association 20173098 , (Europe PMC )0.62 IntAct RING1 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy, pull down, ubiquitinase assay colocalization, physical, physical association, ubiquitination reaction 22907436 , 29187402 , (Europe PMC )0.65 BioGRID, IntAct RMDN1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID RNASE4 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID RNASEL Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT RNF125 Affinity Capture-Western, Reconstituted Complex physical 25591766 , (Europe PMC )NA BioGRID RNF128 Reconstituted Complex, Two-hybrid physical 23370271 , (Europe PMC )NA BioGRID RNF2 Affinity Capture-Western physical 22907436 , 23318437 , (Europe PMC )NA BioGRID RNF20 Affinity Capture-Western, Reconstituted Complex, pull down association, physical 16337599 , 19410543 , (Europe PMC )0.35 BioGRID, IntAct RNF34 Affinity Capture-Western physical 17121812 , (Europe PMC )NA BioGRID RNF38 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 20308539 , 23973461 , (Europe PMC )NA BioGRID RNF39 Affinity Capture-Western physical 17719541 , (Europe PMC )NA BioGRID RNF40 pull down association 19410543 , (Europe PMC )0.35 IntAct RNF43 Affinity Capture-Western physical 21108931 , (Europe PMC )NA BioGRID RORC Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID RPA1 Affinity Capture-Western, Reconstituted Complex, enzyme linked immunosorbent assay physical, physical association 11751427 , 15489903 , 15735006 , 23267009 , (Europe PMC )0.40 BioGRID, IntAct RPA2 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT RPGRIP1L Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct RPL10A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL10L Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL11 Affinity Capture-MS, Affinity Capture-Western physical 14612427 , 15308643 , 23169665 , 23443559 , (Europe PMC )NA BioGRID RPL12 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL13 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL14 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL15 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL18 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL18A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL19 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL21 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL23 Affinity Capture-MS, Affinity Capture-Western physical 15308643 , 23443559 , (Europe PMC )NA BioGRID RPL23A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL24 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL26 Affinity Capture-MS, Affinity Capture-Western physical 20542919 , 23443559 , (Europe PMC )NA BioGRID RPL26L1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL27 Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID RPL27AP6 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL28 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RPL29P11 Affinity Capture-MS physical 25609649 , (Europe PMC )NA BioGRID RPL3 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL30 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL31 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL36P14 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID RPL37A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL4 Affinity Capture-MS, Affinity Capture-Western physical 23443559 , 26908445 , (Europe PMC )NA BioGRID RPL5 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 15308643 , 22653443 , 23169665 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT RPL6 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL7 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPL7A Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID RPL8 Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID RPLP0 Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID RPLP2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPRD1A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS10 Affinity Capture-MS, Two-hybrid physical 15536084 , 23443559 , (Europe PMC )NA BioGRID RPS13 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RPS14 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS15 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS15P2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS16 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RPS17 Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID RPS18 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RPS19 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RPS19BP1 anti bait coimmunoprecipitation association 17964266 , (Europe PMC )0.35 IntAct RPS2 Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID RPS24 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS25 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS26 Affinity Capture-MS, Affinity Capture-Western physical 23443559 , 23728348 , (Europe PMC )NA BioGRID RPS27 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS27A Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 21561866 , 22653443 , (Europe PMC )0.35 BioGRID, IntAct, MINT RPS3 FRET, fluorescent resonance energy transfer, proximity ligation assay, pull down association, direct interaction, physical, physical association 19656744 , (Europe PMC )0.63 BioGRID, IntAct RPS3A Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID RPS4X Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID RPS6 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS7 Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation association, physical 17310983 , 19683495 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct RPS8 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPS9 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RPUSD4 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID RRM2 Affinity Capture-Western physical 12615712 , (Europe PMC )NA BioGRID RRM2B Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical, physical association 12615712 , 19015526 , (Europe PMC )0.35, 0.40 BioGRID, IntAct RRP1B Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID RUNX2 Affinity Capture-Western physical 23618908 , (Europe PMC )NA BioGRID RYBP Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation association, physical, physical association 19098711 , (Europe PMC )0.50 BioGRID, IntAct, MINT RYK Affinity Capture-MS physical 21875946 , (Europe PMC )NA BioGRID S100A1 molecular sieving direct interaction 20591429 , (Europe PMC )0.44 IntAct, MINT S100A2 molecular sieving direct interaction 20591429 , (Europe PMC )0.44 IntAct, MINT S100A4 Affinity Capture-Western, Reconstituted Complex, confocal microscopy, cross-linking study, far western blotting, fluorescence polarization spectroscopy, molecular sieving, proximity ligation assay colocalization, direct interaction, physical, physical association 11527429 , 19740107 , 20070253 , 20591429 , 23752197 , (Europe PMC )0.79 BioGRID, IntAct, MINT S100A6 Reconstituted Complex, molecular sieving direct interaction, physical 20591429 , 23796514 , (Europe PMC )0.44 BioGRID, IntAct, MINT S100A8 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct S100B Affinity Capture-Western, molecular sieving direct interaction, physical 15178678 , 20591429 , (Europe PMC )0.44 BioGRID, IntAct, MINT SACS Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SAE1 anti tag coimmunoprecipitation covalent binding 15327968 , (Europe PMC )0.44 IntAct, MINT SAFB Affinity Capture-Western, anti bait coimmunoprecipitation, fluorescence microscopy, pull down colocalization, physical, physical association 21130767 , (Europe PMC )0.56 BioGRID, IntAct, MINT SAFB2 Affinity Capture-Western, pull down physical, physical association 21130767 , (Europe PMC )0.40 BioGRID, IntAct, MINT SAMD7 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SARS2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT SART1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID SAT1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct SBF2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SCAMP1 Two-hybrid, two hybrid array physical, physical association 16713569 , (Europe PMC )0.37 BioGRID, IntAct SCO2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID SEC63 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SENP1 Affinity Capture-Western physical 19339993 , (Europe PMC )NA BioGRID SENP3 Affinity Capture-Western, Co-localization physical 21316347 , (Europe PMC )NA BioGRID SERBP1 Affinity Capture-Western physical 16455055 , (Europe PMC )NA BioGRID SERPINB9 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct SERPINH1 Affinity Capture-Western physical 17977830 , (Europe PMC )NA BioGRID SET Affinity Capture-Western, Reconstituted Complex physical 21911363 , (Europe PMC )NA BioGRID SETD1A Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, physical 23870121 , (Europe PMC )0.53 BioGRID, IntAct SETD2 Affinity Capture-Western physical 18585004 , (Europe PMC )NA BioGRID SETD7 Biochemical Activity, Co-crystal Structure, Two-hybrid, competition binding, enzymatic study, methyltransferase assay, methyltransferase radiometric assay, pull down, two hybrid, x-ray crystallography direct interaction, methylation reaction, physical, physical association 15525938 , 16415881 , 17108971 , 17805299 , 21245319 , 21988832 , (Europe PMC )0.92 BioGRID, IntAct SF3B2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID SFN Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, isothermal titration calorimetry, x-ray crystallography association, direct interaction, physical 11896572 , 14517281 , 17546054 , 20206173 , 21625211 , (Europe PMC )0.67 BioGRID, IntAct, MINT SIN3A Affinity Capture-Western, Reconstituted Complex physical 10521394 , 11359905 , (Europe PMC )NA BioGRID SIN3A anti bait coimmunoprecipitation, pull down physical association 10823891 , 11359905 , (Europe PMC )0.59 IntAct, MINT SIN3B Affinity Capture-Western, Two-hybrid physical 22028823 , (Europe PMC )NA BioGRID SIRT1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, acetylase assay, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, deacetylase assay, pull down association, deacetylation reaction, direct interaction, physical, physical association, physical interaction 11672523 , 12006491 , 15205477 , 17964266 , 18235501 , 18235502 , 18753379 , 21149449 , 21245319 , 22389628 , 22689577 , 22735644 , (Europe PMC )0.96 BioGRID, IntAct SIRT7 Affinity Capture-MS physical 22586326 , (Europe PMC )NA BioGRID SIVA1 Affinity Capture-Western physical 19590512 , 25431847 , (Europe PMC )NA BioGRID SKI Affinity Capture-Western physical 21149449 , (Europe PMC )NA BioGRID SKP1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT SLAMF1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SLC25A5 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID SLC2A12 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID SLC7A2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SLC9A9 Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID SMAD1 Affinity Capture-Western physical 22588298 , (Europe PMC )NA BioGRID SMAD2 Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, proximity ligation assay physical, physical association 12732139 , 19345189 , 19580641 , 23687300 , 25241761 , 25670079 , (Europe PMC )0.70 BioGRID, IntAct SMAD3 Affinity Capture-Western, Co-localization, Reconstituted Complex physical 12732139 , 23687300 , 24157709 , (Europe PMC )NA BioGRID SMAD7 Affinity Capture-Western physical 17172861 , (Europe PMC )NA BioGRID SMARCA4 Affinity Capture-Western, Co-fractionation, Reconstituted Complex, anti bait coimmunoprecipitation association, physical 11950834 , 17666433 , 18303029 , 21900401 , (Europe PMC )0.35 BioGRID, IntAct SMARCA5 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT SMARCAL1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT SMARCB1 Affinity Capture-Western, Co-fractionation, Reconstituted Complex physical 11950834 , (Europe PMC )NA BioGRID SMARCC1 Affinity Capture-Western, Co-fractionation, anti bait coimmunoprecipitation association, physical 11950834 , 18303029 , (Europe PMC )0.35 BioGRID, IntAct SMARCD1 Affinity Capture-Western physical 18303029 , (Europe PMC )NA BioGRID SMARCD2 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID SMG5 Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification association, physical 22653443 , 25609649 , (Europe PMC )0.53 BioGRID, IntAct, MINT SMG7 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical 22653443 , 27462439 , (Europe PMC )0.35 BioGRID, IntAct, MINT SMN1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid physical, physical association 11704667 , 21900206 , (Europe PMC )0.37 BioGRID, IntAct, MINT SMURF1 Affinity Capture-Western physical 20484049 , (Europe PMC )NA BioGRID SMYD2 Affinity Capture-Western, Biochemical Activity, isothermal titration calorimetry, methyltransferase assay, methyltransferase radiometric assay, tandem affinity purification, x-ray crystallography adp ribosylation reaction, direct interaction, methylation reaction, physical 17108971 , 17805299 , 18065756 , 21782458 , 25609649 , (Europe PMC )0.81 BioGRID, IntAct, MINT SNAI1 Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 20385133 , 28067227 , (Europe PMC )0.52 BioGRID, IntAct, MINT SNAI2 Affinity Capture-MS physical 23851495 , (Europe PMC )NA BioGRID SNRPD3 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID SNRPN Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct SNW1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID SNX12 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SOCS1 Affinity Capture-Western, Reconstituted Complex physical 20005840 , (Europe PMC )NA BioGRID SOX4 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down physical, physical association 19234109 , (Europe PMC )0.59 BioGRID, IntAct SP1 Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation physical, physical association 12665570 , 15574328 , 15674334 , 15710382 , 16740634 , 18765668 , 19846904 , 20570896 , 21325822 , 21831840 , 23650532 , 8463313 , 9492043 , 9685344 , (Europe PMC )0.59 BioGRID, IntAct, MINT SP3 Affinity Capture-Western physical 12665570 , (Europe PMC )NA BioGRID SPESP1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SPICE1 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct SPSB1 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID SQSTM1 Affinity Capture-Western, Reconstituted Complex physical 16793543 , 25144556 , 27031960 , (Europe PMC )NA BioGRID SRC Biochemical Activity physical 25071020 , (Europe PMC )NA BioGRID SREBF1 cross-linking study physical association 22265415 , (Europe PMC )0.40 IntAct SREBF2 anti bait coimmunoprecipitation, cross-linking study physical association 22265415 , (Europe PMC )0.52 IntAct SRPK1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 21130767 , (Europe PMC )NA BioGRID SRPK1 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down physical association 21130767 , (Europe PMC )0.59 IntAct, MINT SRSF1 Affinity Capture-Western, Biochemical Activity physical 20805487 , (Europe PMC )NA BioGRID SRSF6 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID SSX2IP Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct STAM2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID STAMBP Biochemical Activity physical 27561390 , (Europe PMC )NA BioGRID STARD10 Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID STAT6 Two-hybrid physical 20121258 , (Europe PMC )NA BioGRID STK11 Affinity Capture-Western, chromatin immunoprecipitation assay association, physical 11430832 , 21317932 , (Europe PMC )0.35 BioGRID, IntAct STK4 Co-localization, proximity ligation assay physical, physical association 25241761 , (Europe PMC )0.40 BioGRID, IntAct STT3B Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID STUB1 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 15001357 , 15911628 , 17666403 , 18223694 , 20618441 , 21268072 , 22254155 , 23134341 , 25144556 , 25543083 , 26330542 , 27775703 , 27807478 , (Europe PMC )NA BioGRID STX2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID STX5 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct STXBP4 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID SULT1E1 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct SUMO1 Two-hybrid, comigration in sds page, pull down covalent binding, direct interaction, physical, physical association 10961991 , 16732283 , 19684601 , 20534433 , (Europe PMC )0.72 BioGRID, IntAct SUMO2 pull down association 20534433 , (Europe PMC )0.35 IntAct SUPT3H Affinity Capture-Western, Synthetic Growth Defect genetic, physical 18250150 , 23284306 , (Europe PMC )NA BioGRID SUPT6H Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID SUPT7L Affinity Capture-Western physical 18250150 , (Europe PMC )NA BioGRID SYVN1 Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, imaging technique, pull down colocalization, physical, physical association 17170702 , 21903092 , 26254280 , (Europe PMC )0.61 BioGRID, IntAct, MINT TADA1 Affinity Capture-Western physical 18250150 , (Europe PMC )NA BioGRID TADA2A Affinity Capture-Western physical 18250150 , (Europe PMC )NA BioGRID TADA3 Affinity Capture-MS, Affinity Capture-Western physical 11707411 , 17272277 , 17452980 , 18250150 , 23443559 , (Europe PMC )NA BioGRID TAF1 Affinity Capture-Western, Biochemical Activity physical 10359315 , 15053879 , (Europe PMC )NA BioGRID TAF10 Affinity Capture-Western physical 18250150 , (Europe PMC )NA BioGRID TAF1A Reconstituted Complex physical 10913176 , (Europe PMC )NA BioGRID TAF1B Reconstituted Complex physical 10913176 , (Europe PMC )NA BioGRID TAF1C Reconstituted Complex physical 10913176 , (Europe PMC )NA BioGRID TAF5 Affinity Capture-Western physical 15053879 , (Europe PMC )NA BioGRID TAF5L Affinity Capture-Western physical 18250150 , (Europe PMC )NA BioGRID TAF6 Affinity Capture-Western, Reconstituted Complex physical 20096117 , (Europe PMC )NA BioGRID TAF9 Affinity Capture-Western, Reconstituted Complex physical 11278372 , 18250150 , 7761466 , (Europe PMC )NA BioGRID TBC1D24 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID TBC1D4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TBP Affinity Capture-Western, Reconstituted Complex, far western blotting, pull down direct interaction, physical, physical association 10359315 , 11313951 , 12379483 , 1465435 , 7799929 , 8083962 , 9349482 , (Europe PMC )0.40, 0.44 BioGRID, IntAct, MINT TBPL1 Affinity Capture-Western, Reconstituted Complex physical 28082682 , (Europe PMC )NA BioGRID TCEAL1 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID TCEAL4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TCF4 Affinity Capture-MS, Reconstituted Complex, pull down, tandem affinity purification association, physical, physical association 25402006 , 25609649 , (Europe PMC )0.56 BioGRID, IntAct, MINT TCP1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT TDG Two-hybrid physical 10961991 , (Europe PMC )NA BioGRID TDRD12 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TEP1 Reconstituted Complex physical 10597287 , (Europe PMC )NA BioGRID TERT Dosage Rescue, Phenotypic Enhancement genetic 23284306 , (Europe PMC )NA BioGRID TFAP2A Affinity Capture-Western, Co-localization, Reconstituted Complex, Two-hybrid physical 12226108 , 16288208 , (Europe PMC )NA BioGRID TFAP2B Affinity Capture-Western physical 20159018 , (Europe PMC )NA BioGRID TFAP2C Reconstituted Complex physical 12226108 , (Europe PMC )NA BioGRID TFAP4 Affinity Capture-Western physical 19505873 , (Europe PMC )NA BioGRID TFDP1 Affinity Capture-Western, Reconstituted Complex physical 8816502 , (Europe PMC )NA BioGRID TFIP11 Affinity Capture-Western, Reconstituted Complex physical 26460617 , (Europe PMC )NA BioGRID TFRC Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TGM2 Affinity Capture-Western physical 27031960 , (Europe PMC )NA BioGRID THAP1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID THAP12 Reconstituted Complex physical 12384512 , (Europe PMC )NA BioGRID THAP8 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct THRAP3 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID THRB Affinity Capture-Western physical 11258898 , (Europe PMC )NA BioGRID TIMM50 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TK1 Two-hybrid, two hybrid, two hybrid pooling approach physical, physical association 16169070 , 21900206 , (Europe PMC )0.55 BioGRID, IntAct, MINT TMED9 Co-fractionation physical 9472029 , (Europe PMC )NA BioGRID TMEM200A Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID TMSB4X two hybrid pooling approach physical association 16169070 , (Europe PMC )0.37 IntAct TNFAIP3 Affinity Capture-Western physical 23471665 , 24099634 , (Europe PMC )NA BioGRID TNK2 Affinity Capture-Western physical 23402884 , (Europe PMC )NA BioGRID TOE1 anti bait coimmunoprecipitation, biophysical, pull down association, direct interaction 19508870 , (Europe PMC )0.58 IntAct, MINT TOM1L1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID TOP1 Affinity Capture-Western, Two-hybrid physical 10468612 , 11805286 , 18697815 , (Europe PMC )NA BioGRID TOP1MT Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct TOP2A Affinity Capture-Western, Reconstituted Complex, Synthetic Growth Defect genetic, physical 10666337 , 23284306 , (Europe PMC )NA BioGRID TOP2B Affinity Capture-Western, Reconstituted Complex physical 10666337 , (Europe PMC )NA BioGRID TOP3A anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TOPORS Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation physical, physical association 11842245 , 15247280 , 16122737 , 17290218 , 17803295 , (Europe PMC )0.40 BioGRID, IntAct, MINT TOR1AIP2 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TP53 Affinity Capture-Western, Co-crystal Structure, Co-fractionation, Co-purification, FRET, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, comigration in gel electrophoresis, comigration in non denaturing gel electrophoresis, cosedimentation in solution, cross-linking study, electron microscopy, mass spectrometry studies of complexes, molecular sieving, nuclear magnetic resonance, pull down, tandem affinity purification, transmission electron microscopy, two hybrid, ubiquitin reconstruction, x ray scattering, x-ray crystallography association, direct interaction, physical, physical association 14580323 , 14985081 , 15383276 , 16009130 , 16291740 , 16461914 , 17332328 , 17612295 , 17620598 , 18087040 , 18414054 , 19011633 , 19339993 , 19667193 , 20004160 , 20080206 , 20159469 , 20235143 , 20364130 , 21084564 , 21178074 , 21231916 , 21522129 , 21988832 , 22522597 , 22653443 , 22819825 , 22972749 , 24037342 , 24374182 , 24722987 , 25402006 , 25603536 , 25609649 , 27462439 , 8035799 , (Europe PMC )0.98 BioGRID, IntAct, MINT TP53BP1 Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure, Co-localization, Protein-peptide, Reconstituted Complex, Two-hybrid physical 11877378 , 12110597 , 12351827 , 14978302 , 15364958 , 15611139 , 20307547 , 22084066 , 25651062 , 26022179 , 27546791 , 8016121 , (Europe PMC )NA BioGRID TP53BP1 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, classical fluorescence spectroscopy, nuclear magnetic resonance, peptide array, pull down, two hybrid, x-ray crystallography association, direct interaction, physical association 11877378 , 14985081 , 17805299 , 19433796 , 22653443 , 25579814 , 25651062 , 25837623 , (Europe PMC )0.83, 0.88 IntAct, MINT TP53BP2 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, pull down, solid phase assay, two hybrid, x-ray crystallography association, direct interaction, physical, physical association 14985081 , 18275817 , 21513714 , 8016121 , 8668206 , 8875926 , (Europe PMC )0.83 BioGRID, IntAct, MINT TP53INP1 Affinity Capture-Western, Reconstituted Complex physical 11511362 , 12851404 , (Europe PMC )NA BioGRID TP53RK Reconstituted Complex physical 12659830 , (Europe PMC )NA BioGRID TP63 Affinity Capture-Western, Synthetic Rescue, anti bait coimmunoprecipitation genetic, physical, physical association 19345189 , 21511729 , 21741598 , 22575646 , 23687300 , 24554706 , 25417702 , (Europe PMC )0.59 BioGRID, IntAct TP73 Affinity Capture-Western, Two-hybrid physical 21508668 , 25417702 , 9802988 , 9891077 , (Europe PMC )NA BioGRID TPM1 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID TPM3 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID TPM4 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID TPT1 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, two hybrid, two hybrid pooling approach physical, physical association 21081126 , 22157679 , 22451927 , (Europe PMC )0.71 BioGRID, IntAct, MINT TRAF1 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TRAF6 Affinity Capture-Western, Biochemical Activity physical 27818144 , (Europe PMC )NA BioGRID TRAPPC11 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID TRIAP1 Affinity Capture-RNA physical 15735003 , (Europe PMC )NA BioGRID TRIM24 Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical, physical association 19556538 , 22389628 , 24820418 , (Europe PMC )0.52 BioGRID, IntAct TRIM27 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 20972456 , (Europe PMC )NA BioGRID TRIM28 Affinity Capture-Western, Biochemical Activity, pull down association, physical 17056014 , 20858735 , 20864041 , (Europe PMC )0.35 BioGRID, IntAct TRIM32 Affinity Capture-Western physical 25146927 , (Europe PMC )NA BioGRID TRIM39 Affinity Capture-Western, Biochemical Activity physical 23213260 , (Europe PMC )NA BioGRID TRIM45 Affinity Capture-Western physical 28542145 , (Europe PMC )NA BioGRID TRIM59 Affinity Capture-Western physical 25046164 , (Europe PMC )NA BioGRID TRIM65 Affinity Capture-Western physical 27012201 , (Europe PMC )NA BioGRID TRIM8 Affinity Capture-Western physical 22262183 , (Europe PMC )NA BioGRID TRMT10C Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TRMT11 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID TRRAP Affinity Capture-Western, Co-localization, Reconstituted Complex physical 12138177 , 18250150 , (Europe PMC )NA BioGRID TSC22D1 Affinity Capture-Western, Two-hybrid physical 22870275 , (Europe PMC )NA BioGRID TSC22D3 Affinity Capture-Western, Co-localization, Reconstituted Complex physical 25168242 , (Europe PMC )NA BioGRID TSG101 Affinity Capture-Western physical 11172000 , (Europe PMC )NA BioGRID TSNAX Dosage Rescue genetic 20506231 , (Europe PMC )NA BioGRID TSPAN10 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TSPYL4 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TTC28 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID TTK Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 19332559 , (Europe PMC )NA BioGRID TTLL5 Affinity Capture-Western physical 20308539 , (Europe PMC )NA BioGRID TUBA1A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TUBA1C Affinity Capture-MS physical 23443559 , 25144556 , (Europe PMC )NA BioGRID TUBA4A Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TUBA8 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID TUBB Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT TUBB2A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22653443 , 23443559 , 25144556 , (Europe PMC )0.35 BioGRID, IntAct, MINT TUBB3 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TUBB4B Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TUBG1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID TWIST1 Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, filter binding, pull down association, direct interaction, physical, physical association 18504427 , 22975381 , 25402006 , (Europe PMC )0.82 BioGRID, IntAct TWIST2 pull down physical association 22975381 , (Europe PMC )0.40 IntAct TWNK anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT TXN Reconstituted Complex physical 19681600 , (Europe PMC )NA BioGRID TXNIP Affinity Capture-Western physical 23880345 , (Europe PMC )NA BioGRID TXNRD1 Affinity Capture-Western physical 15824742 , (Europe PMC )NA BioGRID UBA1 ubiquitinase assay ubiquitination reaction 29187402 , (Europe PMC )0.44 IntAct UBB Affinity Capture-MS, anti bait coimmunoprecipitation physical, physical association 17936559 , 23443559 , (Europe PMC )0.40 BioGRID, IntAct UBC Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down association, physical, physical association 17139261 , 17159902 , 17170702 , 17268548 , 17290220 , 17568776 , 18309296 , 18388957 , 18566590 , 19098711 , 19536131 , 19619542 , 19798103 , 25168242 , 25471832 , (Europe PMC )0.96 BioGRID, IntAct, MINT UBD Affinity Capture-Western physical 21396347 , (Europe PMC )NA BioGRID UBE2A Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 12640129 , 22083959 , 24506068 , 28031328 , (Europe PMC )NA BioGRID UBE2B Affinity Capture-Western physical 22083959 , (Europe PMC )NA BioGRID UBE2E1 ubiquitinase assay ubiquitination reaction 29187402 , (Europe PMC )0.44 IntAct UBE2I Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, pull down, two hybrid direct interaction, physical, physical association 10380882 , 10562557 , 10788439 , 10961991 , 11853669 , 12565873 , 15327968 , 16122737 , 16442531 , 17060459 , 17709345 , 18624398 , 19684601 , 21829513 , 22214662 , 23202365 , 23772552 , 8921390 , (Europe PMC )0.66 BioGRID, IntAct, MINT UBE2K Affinity Capture-Western, PCA physical 23933584 , (Europe PMC )NA BioGRID UBE2M Biochemical Activity physical 15242646 , (Europe PMC )NA BioGRID UBE2N Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 17000756 , 19651615 , (Europe PMC )NA BioGRID UBE2Q1 Affinity Capture-Western, Reconstituted Complex physical 25987028 , (Europe PMC )NA BioGRID UBE2V2 Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID UBE3A Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Reconstituted Complex physical 11027293 , 15001357 , 16493710 , 1661671 , 17131388 , 19364824 , 23040663 , 26789255 , 7708685 , 7724550 , 8090726 , 8380895 , 9450543 , 9688277 , (Europe PMC )NA BioGRID UBE3A molecular sieving, pull down, surface plasmon resonance, two hybrid array, two hybrid prey pooling approach, x-ray crystallography association, direct interaction, physical association 12620801 , 16493710 , 26789255 , 29426014 , (Europe PMC )0.49, 0.77 IntAct, MINT UBE4B Affinity Capture-Western, Biochemical Activity, Co-fractionation, Reconstituted Complex physical 21317885 , 24587254 , 26673821 , (Europe PMC )NA BioGRID UBQLN2 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID UBR4 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID UBR5 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 21383020 , 23443559 , 28689657 , (Europe PMC )NA BioGRID UCHL1 Affinity Capture-Western physical 18666234 , 20395212 , 29126443 , (Europe PMC )NA BioGRID UFD1 Two-hybrid physical 21900206 , (Europe PMC )NA BioGRID UFD1 two hybrid physical association 21900206 , (Europe PMC )0.37 IntAct, MINT UHRF1 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 26102039 , (Europe PMC )NA BioGRID UHRF2 Affinity Capture-Western, Far Western, Reconstituted Complex, anti tag coimmunoprecipitation, antibody array physical, physical association 21952639 , (Europe PMC )0.52 BioGRID, IntAct UIMC1 Affinity Capture-Western, Reconstituted Complex physical 19433585 , (Europe PMC )NA BioGRID UMPS Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID USH2A Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID USO1 Affinity Capture-Western physical 21147777 , (Europe PMC )NA BioGRID USP1 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID USP10 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex physical 20096447 , 24998844 , (Europe PMC )NA BioGRID USP11 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, anti tag coimmunoprecipitation physical, physical association 19615732 , 25471832 , (Europe PMC )0.40 BioGRID, IntAct USP15 Affinity Capture-Western physical 27893708 , (Europe PMC )NA BioGRID USP21 Biochemical Activity physical 27561390 , (Europe PMC )NA BioGRID USP24 Biochemical Activity physical 25578727 , (Europe PMC )NA BioGRID USP28 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT USP29 Affinity Capture-Western, anti tag coimmunoprecipitation physical, physical association 21285945 , (Europe PMC )0.40 BioGRID, IntAct, MINT USP3 Affinity Capture-Western, Biochemical Activity physical 28807825 , (Europe PMC )NA BioGRID USP39 Affinity Capture-MS, anti tag coimmunoprecipitation physical, physical association 19615732 , (Europe PMC )0.40 BioGRID, IntAct USP42 Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation direct interaction, physical, physical association 22085928 , (Europe PMC )0.40, 0.54 BioGRID, IntAct, MINT USP7 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Co-crystal Structure, Protein-peptide, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, classical fluorescence spectroscopy, coimmunoprecipitation, experimental interaction detection, isothermal titration calorimetry, molecular sieving, nuclear magnetic resonance, pull down, x-ray crystallography association, deubiquitination reaction, direct interaction, physical, physical association 11923872 , 14506283 , 15916963 , 16402859 , 16474402 , 16845383 , 17268548 , 17380154 , 17525743 , 20713061 , 20816748 , 21170034 , 21845734 , 22056774 , 22084066 , 22653443 , 23382381 , 23388826 , 24462112 , 25283148 , 26238070 , 26460617 , (Europe PMC )0.97 BioGRID, IntAct, MINT UTP14A Affinity Capture-Western, Reconstituted Complex physical 21078665 , (Europe PMC )NA BioGRID VASP Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID VAT1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID VCP Affinity Capture-MS, Affinity Capture-Western physical 23383273 , 23443559 , (Europe PMC )NA BioGRID VDR Affinity Capture-Western, anti bait coimmunoprecipitation, chromatin immunoprecipitation assay, fluorescence microscopy association, colocalization, physical, physical association 20227041 , (Europe PMC )0.54 BioGRID, IntAct VHL Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 16678111 , 21942715 , (Europe PMC )NA BioGRID VIM Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID VRK1 Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy, protein kinase assay, pull down colocalization, phosphorylation reaction, physical, physical association 10951572 , 11883897 , 15542844 , 24492002 , 29340707 , (Europe PMC )0.76 BioGRID, IntAct VRK2 Affinity Capture-Western, Biochemical Activity physical 16704422 , (Europe PMC )NA BioGRID WDR33 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct WDR48 Affinity Capture-MS, anti tag coimmunoprecipitation physical, physical association 19615732 , (Europe PMC )0.40 BioGRID, IntAct WDR5 Reconstituted Complex, anti tag coimmunoprecipitation, pull down association, physical 15960975 , 19433796 , 23870121 , (Europe PMC )0.69 BioGRID, IntAct WDR77 Affinity Capture-MS physical 25144556 , (Europe PMC )NA BioGRID WDR82 Reconstituted Complex, anti tag coimmunoprecipitation association, physical 23870121 , (Europe PMC )0.35 BioGRID, IntAct WRN Affinity Capture-Western, Reconstituted Complex, enzyme linked immunosorbent assay, far western blotting, fluorescence microscopy colocalization, direct interaction, physical 11427532 , 12080066 , 15735006 , (Europe PMC )0.65 BioGRID, IntAct WT1 Affinity Capture-Western, Reconstituted Complex physical 8389468 , 9556563 , (Europe PMC )NA BioGRID WWOX Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation physical, physical association 11058590 , 15580310 , 16219768 , (Europe PMC )0.40 BioGRID, IntAct, MINT XAF1 Affinity Capture-Western, Phenotypic Enhancement, Reconstituted Complex genetic, physical 25313037 , (Europe PMC )NA BioGRID XPC Affinity Capture-Western physical 24258024 , (Europe PMC )NA BioGRID XPO1 anti bait coimmunoprecipitation physical association 17268548 , 18952844 , (Europe PMC )0.59 IntAct, MINT XRCC1 Affinity Capture-Western, anti bait coimmunoprecipitation association, physical 15044383 , (Europe PMC )0.35 BioGRID, IntAct XRCC6 Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 15782130 , (Europe PMC )0.40 BioGRID, IntAct YBX1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 11175333 , 15136035 , 21344396 , 23443559 , 25144556 , (Europe PMC )NA BioGRID YTHDC2 anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT YTHDF1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID YWHAB Affinity Capture-Western physical 17898864 , (Europe PMC )NA BioGRID YWHAE Affinity Capture-MS, fluorescence polarization spectroscopy association, physical 18812399 , 23443559 , (Europe PMC )0.35 BioGRID, IntAct, MINT YWHAG anti tag coimmunoprecipitation, coimmunoprecipitation, fluorescence polarization spectroscopy association 18812399 , 19933256 , 22653443 , (Europe PMC )0.64 IntAct, MINT YWHAQ anti tag coimmunoprecipitation association 22653443 , (Europe PMC )0.35 IntAct, MINT YWHAZ Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation association, physical, physical association 16376338 , 22653443 , 9620776 , (Europe PMC )0.56 BioGRID, IntAct, MINT YY1 Affinity Capture-Western, Reconstituted Complex, pull down physical, physical association 15210108 , 15295102 , 18026119 , 22440256 , 25402006 , (Europe PMC )0.40 BioGRID, IntAct YY2 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct ZBTB16 Affinity Capture-Western physical 24821727 , (Europe PMC )NA BioGRID ZBTB17 Affinity Capture-Western physical 19901969 , 21804610 , (Europe PMC )NA BioGRID ZBTB2 Affinity Capture-Western, Reconstituted Complex physical 19380588 , (Europe PMC )NA BioGRID ZBTB33 Affinity Capture-Western, Co-localization physical 25288747 , 26183023 , (Europe PMC )NA BioGRID ZBTB7A Affinity Capture-Western, Reconstituted Complex physical 19244234 , 24857950 , (Europe PMC )NA BioGRID ZBTB8A Affinity Capture-Western, Reconstituted Complex physical 23329847 , (Europe PMC )NA BioGRID ZCCHC10 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct ZHX1 Two-hybrid physical 15383276 , (Europe PMC )NA BioGRID ZIC3 Reconstituted Complex, pull down physical, physical association 25402006 , (Europe PMC )0.40 BioGRID, IntAct ZMIZ1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 17584785 , (Europe PMC )NA BioGRID ZMIZ2 Two-hybrid physical 17584785 , (Europe PMC )NA BioGRID ZMYND11 Affinity Capture-Western physical 17721438 , (Europe PMC )NA BioGRID ZNF148 Affinity Capture-Western, Reconstituted Complex physical 11416144 , (Europe PMC )NA BioGRID ZNF24 Two-hybrid, two hybrid pooling approach physical, physical association 16169070 , (Europe PMC )0.37 BioGRID, IntAct ZNF300 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ZNF302 Two-hybrid physical 18307271 , (Europe PMC )NA BioGRID ZNF385A anti bait coimmunoprecipitation physical association 17719541 , (Europe PMC )0.40 IntAct ZNF420 Affinity Capture-Western, Reconstituted Complex, anti tag coimmunoprecipitation, pull down association, direct interaction, physical, physical association 19377469 , 20713054 , (Europe PMC )0.59 BioGRID, IntAct, MINT ZNF619 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ZNF668 Affinity Capture-Western physical 21852383 , (Europe PMC )NA BioGRID ZNF679 Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID ZNF763 Synthetic Growth Defect genetic 23284306 , (Europe PMC )NA BioGRID ZNF839 Two-hybrid physical 27229929 , (Europe PMC )NA BioGRID ZNHIT1 Reconstituted Complex physical 17380123 , (Europe PMC )NA BioGRID ZWINT Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID
Phosphorylating Kinases Phosphoresidues Detection Method PubMed IDs Source
Visualize a network of protein kinases and phosphatases phosphorylating and dephosphorylating this protein respectively
ATM S15_PSVEPPLsQETFSDL , S20_PLSQETFsDLWKLLP , S33_LPENNVLsPLPSQAM , S37_NVLSPLPsQAMDDLM , S46_AMDDLMLsPDDIEQW , S9_EEPQSDPsVEPPLSQ , LTP, in vitro, in vivo 10673501 , 10864201 , 11551930 , 11709713 , 11780126 , 11875057 , 15159397 , 16906133 , 20123963 , 9765199 , 9843217 ,(Europe PMC )HPRD, PhosphoELM , PhosphoSitePlus , ATR S15_PSVEPPLsQETFSDL , S20_PLSQETFsDLWKLLP , S37_NVLSPLPsQAMDDLM , T18_EPPLSQEtFSDLWKL , in vitro, in vivo 10673501 , 10747897 , 10951572 , 11551930 , 11709713 , 11883897 , 15159397 , 16293623 , 9765199 ,(Europe PMC )HPRD, PhosphoSitePlus , AURKA S106_SQKTYQGsYGFRLGF , S215_DRNTFRHsVVVPYEP , S315_LPNNTSSsPQPKKKP , NA NA PhosphoSitePlus , AURKB S183_CPHHERCsDSDGLAP , S215_DRNTFRHsVVVPYEP , S269_GNLLGRNsFEVRVCA , T211_EYLDDRNtFRHSVVV , T284_CPGRDRRtEEENLRK , NA NA PhosphoSitePlus , Aurora A S215_DRNTFRHsVVVPYEP , S315_LPNNTSSsPQPKKKP , LTP 14702041 , 15469940 ,(Europe PMC )PhosphoELM , BTK S15_PSVEPPLsQETFSDL , NA NA PhosphoSitePlus , CDK1 S315_LPNNTSSsPQPKKKP , NA NA PhosphoSitePlus , CDK2 S315_LPNNTSSsPQPKKKP , S392_FKTEGPDsD , in vitro, in vivo 10348343 , 10747897 , 10884347 , 12064478 , 17287340 , 19413330 , 19664995 ,(Europe PMC )HPRD, PhosphoSitePlus , CDK5 S15_PSVEPPLsQETFSDL , S20_PLSQETFsDLWKLLP , S315_LPNNTSSsPQPKKKP , S33_LPENNVLsPLPSQAM , S46_AMDDLMLsPDDIEQW , in vitro, in vivo 10884347 , 11483158 , 12064478 , 17287340 , 19413330 , 19664995 ,(Europe PMC )HPRD, PhosphoSitePlus , CDK7 S33_LPENNVLsPLPSQAM , S371_AHSSHLKsKKGQSTS , S376_LKSKKGQsTSRHKKL , S378_SKKGQSTsRHKKLMF , S392_FKTEGPDsD , LTP 9315650 , 9372954 ,(Europe PMC )PhosphoELM , PhosphoSitePlus , CDK9 S315_LPNNTSSsPQPKKKP , S33_LPENNVLsPLPSQAM , S392_FKTEGPDsD , in vitro, in vivo 10348343 , 10747897 , 10884347 , 12064478 , 16552184 , 17287340 , 19413330 , 19664995 ,(Europe PMC )HPRD, PhosphoSitePlus , CDK_group S33_LPENNVLsPLPSQAM , LTP 9372954 ,(Europe PMC )PhosphoELM , CHEK1 S15_PSVEPPLsQETFSDL , S20_PLSQETFsDLWKLLP , S378_SKKGQSTsRHKKLMF , S37_NVLSPLPsQAMDDLM , T18_EPPLSQEtFSDLWKL , T387_HKKLMFKtEGPDSD , in vitro, in vivo 10673501 , 11551930 , 11709713 , 9765199 ,(Europe PMC )HPRD, PhosphoSitePlus , CHEK2 S15_PSVEPPLsQETFSDL , S20_PLSQETFsDLWKLLP , S366_PGGSRAHsSHLKSKK , S378_SKKGQSTsRHKKLMF , S37_NVLSPLPsQAMDDLM , T18_EPPLSQEtFSDLWKL , NA NA PhosphoSitePlus , CHK1 S20_PLSQETFsDLWKLLP , LTP 17339337 ,(Europe PMC )PhosphoELM , CHK2 S20_PLSQETFsDLWKLLP , LTP 17339337 ,(Europe PMC )PhosphoELM , CK1_group T18_EPPLSQEtFSDLWKL , LTP 10606744 ,(Europe PMC )PhosphoELM , CSNK1A1 S20_PLSQETFsDLWKLLP , S6_MEEPQsDPSVEPP , S9_EEPQSDPsVEPPLSQ , T18_EPPLSQEtFSDLWKL , in vitro, in vivo 11875057 , 9765199 ,(Europe PMC )HPRD, PhosphoSitePlus , CSNK1D S20_PLSQETFsDLWKLLP , S9_EEPQSDPsVEPPLSQ , T18_EPPLSQEtFSDLWKL , in vitro 10606744 ,(Europe PMC )HPRD, PhosphoSitePlus , CSNK2A1 S149_PVQLWVDsTPPPGTR , S392_FKTEGPDsD , T150_VQLWVDStPPPGTRV , T155_DSTPPPGtRVRAMAI , T18_EPPLSQEtFSDLWKL , in vitro, in vivo 10348343 , 10747897 , 10884347 , 10951572 , 11709713 , 11883897 , 12628923 , 19413330 ,(Europe PMC )HPRD, PhosphoSitePlus , CSNK2B T18_EPPLSQEtFSDLWKL , in vitro, in vivo 10747897 , 10951572 , 11709713 , 11883897 ,(Europe PMC )HPRD, DAPK1 S20_PLSQETFsDLWKLLP , S269_GNLLGRNsFEVRVCA , T18_EPPLSQEtFSDLWKL , LTP 17339337 ,(Europe PMC )PhosphoELM , PhosphoSitePlus , DAPK3 S20_PLSQETFsDLWKLLP , NA NA PhosphoSitePlus , DNA-PK S15_PSVEPPLsQETFSDL , S37_NVLSPLPsQAMDDLM , LTP , 10446957 , 11483158 , 12959929 , 15381073 ,(Europe PMC )PhosphoELM , DYRK1A S15_PSVEPPLsQETFSDL , NA NA PhosphoSitePlus , DYRK2 S46_AMDDLMLsPDDIEQW , LTP 17349958 , 19965871 ,(Europe PMC )PhosphoELM , PhosphoSitePlus , EIF2AK2 S392_FKTEGPDsD , in vitro, in vivo 10348343 , 10747897 , 10884347 , 19413330 ,(Europe PMC )HPRD, PhosphoSitePlus , GRK5 T55_DDIEQWFtEDPGPDE , NA NA PhosphoSitePlus , GSK-3_group S33_LPENNVLsPLPSQAM , LTP 11483158 ,(Europe PMC )PhosphoELM , GSK3B S33_LPENNVLsPLPSQAM , S376_LKSKKGQsTSRHKKL , in vitro, in vivo 11483158 , 12064478 ,(Europe PMC )HPRD, PhosphoSitePlus , HIPK2 S46_AMDDLMLsPDDIEQW , LTP, in vivo 11780126 , 11875057 , 16212962 , 16729035 ,(Europe PMC )HPRD, PhosphoELM , PhosphoSitePlus , LRRK2 T304_HELPPGStKRALPNN , T377_KSKKGQStSRHKKLM , NA NA PhosphoSitePlus , MAPK1 S15_PSVEPPLsQETFSDL , T55_DDIEQWFtEDPGPDE , in vitro, in vivo 11409876 , 12091386 , 14965474 , 15116093 ,(Europe PMC )HPRD, PhosphoSitePlus , MAPK14 S15_PSVEPPLsQETFSDL , S33_LPENNVLsPLPSQAM , S392_FKTEGPDsD , S46_AMDDLMLsPDDIEQW , in vitro, in vivo 10348343 , 10747897 , 10884347 , 19413330 ,(Europe PMC )HPRD, PhosphoSitePlus , MAPK3 S15_PSVEPPLsQETFSDL , S392_FKTEGPDsD , NA NA PhosphoSitePlus , MAPK8 S20_PLSQETFsDLWKLLP , T81_APAPAAPtPAAPAPA , in vitro, in vivo 11283254 ,(Europe PMC )HPRD, PhosphoSitePlus , MAPK9 S20_PLSQETFsDLWKLLP , NA NA PhosphoSitePlus , MAPKAPK2 S20_PLSQETFsDLWKLLP , NA NA PhosphoSitePlus , MAPKAPK5 S37_NVLSPLPsQAMDDLM , LTP, in vitro 17254968 ,(Europe PMC )HPRD, PhosphoELM , PhosphoSitePlus , MAPK_group T55_DDIEQWFtEDPGPDE , LTP 11409876 ,(Europe PMC )PhosphoELM , NUAK1 S15_PSVEPPLsQETFSDL , S392_FKTEGPDsD , NA NA PhosphoSitePlus , PAK4 S215_DRNTFRHsVVVPYEP , NA NA PhosphoSitePlus , PLK3 S20_PLSQETFsDLWKLLP , in vitro, in vivo 10673501 , 11551930 , 11709713 , 12242661 , 12548019 ,(Europe PMC )HPRD, PhosphoSitePlus , PRKAA1 S20_PLSQETFsDLWKLLP , T18_EPPLSQEtFSDLWKL , NA NA PhosphoSitePlus , PRKACA S378_SKKGQSTsRHKKLMF , NA NA PhosphoSitePlus , PRKCA S371_AHSSHLKsKKGQSTS , S376_LKSKKGQsTSRHKKL , S378_SKKGQSTsRHKKLMF , T377_KSKKGQStSRHKKLM , in vitro 1454855 , 9571186 ,(Europe PMC )HPRD, PhosphoSitePlus , PRKCD S46_AMDDLMLsPDDIEQW , NA NA PhosphoSitePlus , PRKDC S15_PSVEPPLsQETFSDL , S20_PLSQETFsDLWKLLP , S33_LPENNVLsPLPSQAM , S37_NVLSPLPsQAMDDLM , S46_AMDDLMLsPDDIEQW , S9_EEPQSDPsVEPPLSQ , T18_EPPLSQEtFSDLWKL , in vitro, in vivo 10673501 , 10747897 , 10951572 , 11551930 , 11709713 , 11883897 , 9765199 ,(Europe PMC )HPRD, PhosphoSitePlus , SMG1 S15_PSVEPPLsQETFSDL , NA NA PhosphoSitePlus , STK11 S15_PSVEPPLsQETFSDL , S392_FKTEGPDsD , NA NA PhosphoSitePlus , STK17A S20_PLSQETFsDLWKLLP , NA NA PhosphoSitePlus , TAF1 T55_DDIEQWFtEDPGPDE , NA NA PhosphoSitePlus , TP53RK S15_PSVEPPLsQETFSDL , NA NA PhosphoSitePlus , TTK T18_EPPLSQEtFSDLWKL , LTP 19332559 ,(Europe PMC )PhosphoELM , Unknown S15_PSVEPPLsQETFSDL , S20_PLSQETFsDLWKLLP , S313_RALPNNTsSSPQPKK , S314_ALPNNTSsSPQPKKK , S315_LPNNTSSsPQPKKKP , S33_LPENNVLsPLPSQAM , S366_PGGSRAHsSHLKSKK , S392_FKTEGPDsD , S46_AMDDLMLsPDDIEQW , S99_PLSSSVPsQKTYQGS , S9_EEPQSDPsVEPPLSQ , T81_APAPAAPtPAAPAPA , HTP, LTP, in vitro, in vivo 10348343 , 10747897 , 10801407 , 10864201 , 10884347 , 11875057 , 12064478 , 12111733 , 12397361 , 15254178 , 15489221 , 15580310 , 16083285 , 17287340 , 17525332 , 19413330 , 1956339 , 19664995 , 9183006 ,(Europe PMC )HPRD, PhosphoELM , VRK1 T18_EPPLSQEtFSDLWKL , LTP, in vitro, in vivo 10747897 , 10951572 , 11709713 , 11883897 , 15542844 ,(Europe PMC )HPRD, PhosphoELM , PhosphoSitePlus ,