Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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KEGG Pathway - Cell cycle - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| CDC14B | O60729 | TP53, CDC25A, CDC25B, CDC25C, SKP2, MAPK6, SIRT2, KMT5A, FZR1, | Non-protein substrates of this phosphatase are not reported yet |
| CDC25A | P30304 | EGFR, RAF1, CDK1, CDK4, CDK2, MAPK3, MAPK1, CUX1, | Non-protein substrates of this phosphatase are not reported yet |
| CDC25B | P30305 | CDK1, | Non-protein substrates of this phosphatase are not reported yet |
| CDC25C | P30307 | CDK1, | Non-protein substrates of this phosphatase are not reported yet |
| CDC14A | Q9UNH5 | TP53, CDC25A, CDC25B, CDKN1B, IREB2, KIF23, MAPK6, SIRT2, USP6NL, KMT5A, INCENP, FZR1, | Non-protein substrates of this phosphatase are not reported yet |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| CHEK1 | O14757 | PPP2CA, PPP2CB, PPM1D, |
| CHEK2 | O96017 | PPP2CA, PPP2CB, PPM1D, |
| ABL1 | P00519 | PTPN18, PTPN12, |
| MYC | P01106 | PPP2CA, PPP2CB, CTDSP1, |
| TP53 | P04637 | CDC14A, CDC14B, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPM1D, DUSP26, |
| RB1 | P06400 | PPP1CA, PPP1CB, PPP1CC, CTDSPL, PPP2CA, PPP2CB, |
| CDK1 | P06493 | CDC25A, CDC25B, CDC25C, PPP2CA, PPP2CB, |
| CDK4 | P11802 | CDC25A, |
| CDK2 | P24941 | CDC25A, CDKN3, PPP2CA, PPP2CB, PPM1A, PPM1B, |
| RBL1 | P28749 | PPP2CA, PPP2CB, |
| CDC25A | P30304 | CDC14A, CDC14B, |
| CDC25B | P30305 | CDC14A, CDC14B, |
| CDC25C | P30307 | CDC14B, PPP1CA, PPP1CB, PPP1CC, |
| CDKN1B | P46527 | CDC14A, PPM1H, PPP2CB, PPP2CA, |
| GSK3B | P49841 | EPM2A, PPP3CA, PPP3CB, PPP3CC, PTPN1, |
| PLK1 | P53350 | PPP2CA, PPP2CB, |
| PRKDC | P78527 | PPP6C, |
| SMAD3 | P84022 | MTMR4, PPP2CA, PPP2CB, PPM1A, CTDSP1, CTDSP2, CTDSPL, |
| CDK6 | Q00534 | PPM1A, PPM1B, |
| MDM2 | Q00987 | PPP2CA, PPP2CB, PPM1D, |
| RBL2 | Q08999 | PPP2CA, PPP2CB, |
| SKP2 | Q13309 | CDC14B, |
| ATM | Q13315 | PPP1CC, PPP2CA, PPP2CB, PPM1D, |
| SMAD2 | Q15796 | PPM1A, CTDSP1, CTDSP2, CTDSPL, |
| FZR1 | Q9UM11 | CDC14A, CDC14B, |
| TTK | P33981 | PPP1CC, |
| Non-protein substrates in this pathway |
Non-protein substrates involved in this pathway are unknown (yet!)