Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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CDKN3
Gene Name  | CDKN3 (QuickGO) | (A quick tutorial to explore the interctive visulaization) |
| Synonyms | CDKN3, CDI1, CIP2, KAP | |
| Protein Name | CDKN3 |
|
| Alternative Name(s) |
Cyclin-dependent kinase inhibitor 3;3.1.3.16;3.1.3.48;CDK2-associated dual-specificity phosphatase;Cyclin-dependent kinase interactor 1;Cyclin-dependent kinase-interacting protein 2;Kinase-associated phosphatase; | |
| EntrezGene ID | 1033 (Comparitive Toxicogenomics) | |
| UniProt AC (Human) | Q16667 (protein sequence) | |
| Enzyme Class | EC 3.1.3.16 3.1.3.48 (BRENDA ) | |
| Molecular Weight | 23805 Dalton | |
| Protein Length | 212 amino acids (AA) | |
| Genome Browsers | NCBI | ENSG00000100526 (Ensembl) | UCSC | |
| Crosslinking annotations | Query our ID-mapping table | |
| Orthologues | Quest For Orthologues (QFO) | GeneTree | |
| Classification | Superfamily: Class I Cys-based PTPs --> Family: DSP | Historic class: Class I Cys-based PTPs --> VH1-like or DSPs --> CDC14s | CATH ID: 3.90.190.10 | SCOP Fold: CC1 | |
| Phosphatase activity | active | Catalytic signature motif: HCYGGLGR | |
| Domain organization, Expression, Diseases | (show / hide) |
| Protein Domain | InterPro | Pfam | SMART | 3D Structure | PDB | DrugPort | ModBase | SwissModel |
| Polypeptide organization (Pfam) | No Pfam domain found | ||
| Catalytic Site | Mechanism and Catalytic Site Atlas | ||
| Gene Expression | Gene Expression Atlas | Diseases | OMIM | DisGeNet | ClinVar |
| Protein-protein interactions | STRING | IntAct | MINT | BioGRID | ||
| Phosphosites | Phospho.ELM | PhosphoSitePlus | ||
| Localization, Function, Catalytic activity and Sequence | (show / hide) |
| Localization (UniProt annotation) | |||
| Cytoplasm, perinuclear region | |||
| Function (UniProt annotation) | |||
| May play a role in cell cycle regulation Dualspecificity phosphatase active toward substrates containing eitherphosphotyrosine or phosphoserine residues Dephosphorylates CDK2at 'Thr-160' in a cyclin-dependent manner | |||
| Catalytic Activity (UniProt annotation) | |||
| Protein tyrosine phosphate + H(2)O = proteintyrosine + phosphate [a protein]-serine/threonine phosphate + H(2)O= [a protein]-serine/threonine + phosphate | |||
| Protein Sequence | |||
| MKPPSSIQTSEFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLGLCALPGCKFKDVRRNVQKDTEELKSCGIQDIFVFCT RGELSKYRVPNLLDLYQQCGIITHHHPIADGGTPDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYLSD TISPEQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKLAAHLSSRDSQSRSVSR |
| Motif information from Eukaryotic Linear Motif atlas (ELM) | (show / hide) |
ELM Motif | Motif Instance | Description | Motif Regex |
| NA | NA | NA | NA |
| Gene Ontology (P: Process; F: Function and C: Component terms) | (show / hide) | |
| GO:0000079 | P:regulation of cyclin-dependent protein serine/threonine kinase activity |
| GO:0000082 | P:G1/S transition of mitotic cell cycle |
| GO:0004722 | F:protein serine/threonine phosphatase activity |
| GO:0004725 | F:protein tyrosine phosphatase activity |
| GO:0005634 | C:nucleus |
| GO:0005829 | C:cytosol |
| GO:0007050 | P:cell cycle arrest |
| GO:0008138 | F:protein tyrosine/serine/threonine phosphatase activity |
| GO:0008285 | P:negative regulation of cell proliferation |
| GO:0048471 | C:perinuclear region of cytoplasm |
