spacer
Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023

spacer

Protein substrates of human phosphatases

Protein substrates are categorized as per their similarity annotations in Uniprot

AAA ATPase family
Abd-B homeobox family
BCKDHA family
Bcl-2 family
CAS family
CD36 family
CD3Z/FCER1G family
CDC37 family
CDI family
CEF1 family
CRK family
CUT homeobox family
DEAD box helicase family DDX20subfamily
DOK family Type A subfamily
ELL/occludin family
ETS family
Ena/VASP family
FXYD family
G-protein coupled receptor 1 familyOpsin subfamily
G-protein coupled receptor 3 family
G-protein coupled receptor Fz/Smofamily
GAB family
GOLGA2 family
INCENP family
Ikaros C2H2-type zinc-finger proteinfamily
MAGUK family
MDM2/MDM4 family
MPI phosphatase family
MiT/TFE family
N-CoR nuclear receptor corepressorsfamily
NF-kappa-B inhibitor family
NOS family
NifU family
Other
PACS family
PAR3 family
PDCD10 family
PI3/PI4-kinase family
PI3/PI4-kinase family ATM subfamily
PI3K p85 subunit family
PPP phosphatase family PP-1 subfamily
PTEN phosphatase protein family
RBM38 family
RCAN family
RNA polymerase beta' chain family
Rho GDI family
SF3B1 family
SKAP family
SMN family
STAM family
TNF receptor-associated factor familyA subfamily
TRAFAC class dynamin-like GTPasesuperfamily Dynamin/Fzo/YdjA family
TRAFAC class myosin-kinesin ATPasesuperfamily Kinesin family
TRAFAC class translation factor GTPasesuperfamily Classic translation factor GTPase family EF-G/EF-2subfamily
WD repeat CDC20/Fizzy family
WD repeat G protein beta family
WD repeat coronin family
XPO2/CSE1 family
aconitase/IPM isomerase family
actin-binding proteins ADF family
adenomatous polyposis coli (APC)family
adenosylhomocysteinase family
aldolase class II family Adducinsubfamily
alpha-actinin family
alpha-casein family
anion exchanger (TC 2A31) family
bZIP family
bZIP family
bZIP family Jun subfamily
beta-casein family
beta-catenin family
bile acid:sodium symporter (BASS) (TC2A28) family
cAMP-dependent kinase regulatory chainfamily
calreticulin family
calycin superfamily Fatty-acid bindingprotein (FABP) family
caveolin family
centrin family
class V-like SAM-bindingmethyltransferase superfamily Histone-lysine methyltransferasefamily PR/SET subfamily
coilin family
cyclin-dependent kinase 5 activatorfamily
dwarfin/SMAD family
eIF-2-alpha family
eukaryotic initiation factor 4E family
filamin family
glycosyltransferase 3 family
group II decarboxylase family
hexokinase family
histone H1/H5 family
histone H2A family
histone H2B family
histone H3 family
histone H4 family
histone deacetylase family HD type 1subfamily
histone deacetylase family HD type 2subfamily
immunoglobulin superfamily SIGLEC(sialic acid binding Ig-like lectin) family
inositol 1,4,5-trisphosphate 5-phosphatase family
integrin beta chain family
intermediate filament family
lipin family
low molecular weight phosphotyrosineprotein phosphatase family
metallo-dependent hydrolases superfamily DHOase family CAD subfamily
myelin P0 protein family
myelin basic protein family
nuclear hormone receptor family NR3subfamily
nudE family
p53 family
paxillin family
peptidase C14A family
phosphatase 2A regulatory subunit B56family
potassium channel KCNN familyKCa31/KCNN4 subfamily
potassium channel family B (Shab) (TC1A12) subfamily Kv21/KCNB1 sub-subfamily
protein kinase superfamily AGC Ser/Thrprotein kinase family
protein kinase superfamily AGC Ser/Thrprotein kinase family DMPK subfamily
protein kinase superfamily AGC Ser/Thrprotein kinase family PKC subfamily
protein kinase superfamily AGC Ser/Thrprotein kinase family RAC subfamily
protein kinase superfamily AGC Ser/Thrprotein kinase family S6 kinase subfamily
protein kinase superfamily AGC Ser/Thrprotein kinase family cAMP subfamily
protein kinase superfamily AGC Ser/Thrprotein kinase family cGMP subfamily
protein kinase superfamily CAMKSer/Thr protein kinase family
protein kinase superfamily CAMKSer/Thr protein kinase family CHK2 subfamily
protein kinase superfamily CAMKSer/Thr protein kinase family CaMK subfamily
protein kinase superfamily CAMKSer/Thr protein kinase family NIM1 subfamily
protein kinase superfamily CAMKSer/Thr protein kinase family PKD subfamily
protein kinase superfamily CAMKSer/Thr protein kinase family SNF1 subfamily
protein kinase superfamily CK1 Ser/Thrprotein kinase family Casein kinase I subfamily
protein kinase superfamily CMGCSer/Thr protein kinase family CDC2/CDKX subfamily
protein kinase superfamily CMGCSer/Thr protein kinase family GSK-3 subfamily
protein kinase superfamily CMGCSer/Thr protein kinase family MAP kinase subfamily
protein kinase superfamily STE Ser/Thrprotein kinase family MAP kinase kinase kinase subfamily
protein kinase superfamily STE Ser/Thrprotein kinase family MAP kinase kinase subfamily
protein kinase superfamily STE Ser/Thrprotein kinase family STE20 subfamily
protein kinase superfamily Ser/Thrprotein kinase family
protein kinase superfamily Ser/Thrprotein kinase family Aurora subfamily
protein kinase superfamily Ser/Thrprotein kinase family CDC5/Polo subfamily
protein kinase superfamily Ser/Thrprotein kinase family GCN2 subfamily
protein kinase superfamily Ser/Thrprotein kinase family I-kappa-B kinase subfamily
protein kinase superfamily TKL Ser/Thrprotein kinase family
protein kinase superfamily TKL Ser/Thrprotein kinase family RAF subfamily
protein kinase superfamily TKL Ser/Thrprotein kinase family TGFB receptor subfamily
protein kinase superfamily Tyr proteinkinase family
protein kinase superfamily Tyr proteinkinase family ABL subfamily
protein kinase superfamily Tyr proteinkinase family BRK/PTK6/SIK subfamily
protein kinase superfamily Tyr proteinkinase family CSF-1/PDGF receptor subfamily
protein kinase superfamily Tyr proteinkinase family CSK subfamily
protein kinase superfamily Tyr proteinkinase family EGF receptor subfamily
protein kinase superfamily Tyr proteinkinase family Ephrin receptor subfamily
protein kinase superfamily Tyr proteinkinase family FAK subfamily
protein kinase superfamily Tyr proteinkinase family Fibroblast growth factor receptor subfamily
protein kinase superfamily Tyr proteinkinase family Insulin receptor subfamily
protein kinase superfamily Tyr proteinkinase family JAK subfamily
protein kinase superfamily Tyr proteinkinase family SRC subfamily
protein kinase superfamily Tyr proteinkinase family SYK/ZAP-70 subfamily
protein kinase superfamily Tyr proteinkinase family Tie subfamily
protein phosphatase inhibitor 1 family
protein-tyrosine phosphatase family
protein-tyrosine phosphatase familyNon-receptor class 1 subfamily
protein-tyrosine phosphatase familyNon-receptor class 2 subfamily
protein-tyrosine phosphatase familyNon-receptor class subfamily
protein-tyrosine phosphatase familyReceptor class 2A subfamily
protein-tyrosine phosphatase familyReceptor class 4 subfamily
replication factor A protein 2 family
retinoblastoma protein (RB) family
ryanodine receptor (TC 1A31) familyRYR1 subfamily
ryanodine receptor (TC 1A31) familyRYR2 subfamily
selectin/LECAM family
sirtuin family Class I subfamily
small heat shock protein (HSP20)family
splicing factor SR family
sprouty family
stathmin family
sulfatase family
synuclein family
transcription factor STAT family
transient receptor (TC 1A4) familyTrpV subfamily TRPV6 sub-subfamily
troponin I family
troponin T family
type I cytokine receptor family Type 1subfamily
type I cytokine receptor family Type 2subfamily
uracil-DNA glycosylase (UDG)superfamily UNG family
zyxin/ajuba family


spacer
spacer