DEPOD - human DEPhOsphorylation Database

Gene Name	TTK (QuickGO)	Interactive visualization of TTK structures (A quick tutorial to explore the interctive visulaization) Representative structure: 5O91
Synonyms	TTK, MPS1, MPS1L1,
Protein Name	TTK
Alternative Name(s)	Dual specificity protein kinase TTK;2.7.12.1;Phosphotyrosine picked threonine-protein kinase;PYT;
Protein Family	Belongs to the protein kinase superfamily Ser/Thrprotein kinase family
EntrezGene ID	7272 (Comparitive Toxicogenomics)
UniProt AC (Human)	P33981 (protein sequence)
Enzyme Class	2.7.12.1 (BRENDA )
Molecular Weight	97072 Dalton
Protein Length	857 amino acids (AA)
Genome Browsers	NCBI \|
Crosslinking annotations	Query our ID-mapping table
Orthologues	Quest For Orthologues (QFO) \| GeneTree

Protein Domain	InterPro \| Pfam \| SMART	3D Structure	PDB \| DrugPort \| ModBase \| SwissModel
Polypeptide organization (Pfam)
Gene Expression	Gene Expression Atlas The Human Protein Atlas	Disease	OMIM \| ClinVar
Protein-protein interactions	STRING \| IntAct \| MINT \| BioGRID
Phosphosites	Phospho.ELM \| PhosphoSitePlus

Localization (UniProt annotation)
N/A
Function (UniProt annotation)
Phosphorylates proteins on serine, threonine, andtyrosine Probably associated with cell proliferation Essentialfor chromosome alignment by enhancing AURKB activity (via directCDCA8 phosphorylation) at the centromere, and for the mitoticcheckpoint
Catalytic Activity (UniProt annotation)
ATP + a protein = ADP + a phosphoprotein
Protein Sequence
MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMANNPEDWLSLLLKLEKNSVPLS DALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVK KSKQLLQKAVERGAVPLEMLEIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQTSRSECRDLVVPGSKPSGND SCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNP AASSNHWQIPELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEA DNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQ HGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQ MAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGESHNSSSSKTFEKKRGKK

ELM Motif	Motif Instance	Description	Motif Regex
NA	NA	NA	NA

GO:0000776	C:kinetochore
GO:0004674	F:protein serine/threonine kinase activity
GO:0004712	F:protein serine/threonine/tyrosine kinase activity
GO:0004713	F:protein tyrosine kinase activity
GO:0005524	F:ATP binding
GO:0005737	C:cytoplasm
GO:0005819	C:spindle
GO:0007051	P:spindle organization
GO:0007052	P:mitotic spindle organization
GO:0007094	P:mitotic spindle assembly checkpoint
GO:0008284	P:positive regulation of cell proliferation
GO:0010862	P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016020	C:membrane
GO:0016321	P:female meiosis chromosome segregation
GO:0018105	P:peptidyl-serine phosphorylation
GO:0018107	P:peptidyl-threonine phosphorylation
GO:0033316	P:meiotic spindle assembly checkpoint
GO:0034501	P:protein localization to kinetochore
GO:0042803	F:protein homodimerization activity
GO:0043515	F:kinetochore binding
GO:0046777	P:protein autophosphorylation
GO:0051304	P:chromosome separation
GO:1903096	P:protein localization to meiotic spindle midzone

TTK is dephosphorylated by following phosphatases:

Phosphatase Gene Name	Phosphatase UniProt_AC	DephosphoSite and sequence (+/-5) in TTK (P33981)	Bioassay Type	PubMed ID	View in Europe PMC	Reliability of the interaction
PPP1CC	P36873	Thr-676_MQPDTtSVVKD,	in vitro and in vivo	28463114,	Europe PMC

Pathway ID	Pathway Name	Pathway Description (KEGG)
hsa04110	Cell cycle	Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.

Sorry, no REACTOME pathway information here!
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Sorry, no BioGRID interacting protein information here!
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Sorry, no IntAct interacting protein information here!
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Sorry, no MINT interacting protein information here!
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Sorry, no interacting protein information on this protein!
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Sorry, no kinases are known to phosphorylate this protein!
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