DEPOD - human DEPhOsphorylation Database

Basic Information
Phosphatases
Pathway
Interacting Proteins
Phosphorylating Kinases

Gene Name	SMAD2 (QuickGO)	Interactive visualization of SMAD2 structures (A quick tutorial to explore the interctive visulaization) Representative structure: 5XOD
Synonyms	SMAD2, MADH2, MADR2
Protein Name	SMAD2
Alternative Name(s)	Mothers against decapentaplegic homolog 2;MAD homolog 2;Mothers against DPP homolog 2;JV18-1;Mad-related protein 2;hMAD-2;SMAD family member 2;SMAD 2;Smad2;hSMAD2;
Protein Family	Belongs to the dwarfin/SMAD family
EntrezGene ID	4087 (Comparitive Toxicogenomics)
UniProt AC (Human)	Q15796 (protein sequence)
Enzyme Class	N/A
Molecular Weight	52306 Dalton
Protein Length	467 amino acids (AA)
Genome Browsers	NCBI \| ENSG00000175387 (Ensembl) \| UCSC
Crosslinking annotations	Query our ID-mapping table
Orthologues	Quest For Orthologues (QFO) \| GeneTree \| eggNOG - KOG3701 \| eggNOG - ENOG410XQKU
Phosphorylation Network	Visualize

Domain organization, Expression, Diseases

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Localization, Function, Catalytic activity and Sequence

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Motif information from Eukaryotic Linear Motif atlas (ELM)

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Gene Ontology (P: Process; F: Function and C: Component terms)

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GO:0000122	P:negative regulation of transcription by RNA polymerase II
GO:0000790	C:nuclear chromatin
GO:0000978	F:RNA polymerase II proximal promoter sequence-specific DNA binding
GO:0000981	F:RNA polymerase II transcription factor activity
GO:0001077	sequence-specific DNA binding
GO:0001228	F:transcriptional activator activity
GO:0001657	RNA polymerase II proximal promoter sequence-specific DNA binding
GO:0001701	F:transcriptional activator activity
GO:0001706	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001707	P:ureteric bud development
GO:0003682	P:in utero embryonic development
GO:0003690	P:endoderm formation
GO:0003700	P:mesoderm formation
GO:0005160	F:chromatin binding
GO:0005634	F:double-stranded DNA binding
GO:0005654	F:DNA-binding transcription factor activity
GO:0005667	F:transforming growth factor beta receptor binding
GO:0005737	C:nucleus
GO:0005829	C:nucleoplasm
GO:0007179	C:transcription factor complex
GO:0007182	C:cytoplasm
GO:0007183	C:cytosol
GO:0007352	P:transforming growth factor beta receptor signaling pathway
GO:0007369	P:common-partner SMAD protein phosphorylation
GO:0008134	P:SMAD protein complex assembly
GO:0008285	P:zygotic specification of dorsal/ventral axis
GO:0009749	P:gastrulation
GO:0009791	F:transcription factor binding
GO:0009952	P:negative regulation of cell proliferation
GO:0010718	P:response to glucose
GO:0016579	P:post-embryonic development
GO:0017015	P:anterior/posterior pattern specification
GO:0019902	P:positive regulation of epithelial to mesenchymal transition
GO:0023019	P:protein deubiquitination
GO:0030073	P:regulation of transforming growth factor beta receptor signaling pathway
GO:0030324	F:phosphatase binding
GO:0030325	P:signal transduction involved in regulation of gene expression
GO:0030512	P:insulin secretion
GO:0030513	P:lung development
GO:0030618	P:adrenal gland development
GO:0031016	P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031053	P:positive regulation of BMP signaling pathway
GO:0031625	F:transforming growth factor beta receptor
GO:0032444	pathway-specific cytoplasmic mediator activity
GO:0032924	P:pancreas development
GO:0032991	P:primary miRNA processing
GO:0033613	F:ubiquitin protein ligase binding
GO:0034713	C:activin responsive factor complex
GO:0035019	P:activin receptor signaling pathway
GO:0035265	C:protein-containing complex
GO:0035326	F:activating transcription factor binding
GO:0035556	F:type I transforming growth factor beta receptor binding
GO:0038092	P:somatic stem cell population maintenance
GO:0042060	P:organ growth
GO:0042803	F:enhancer binding
GO:0045165	P:intracellular signal transduction
GO:0045892	P:nodal signaling pathway
GO:0045893	P:wound healing
GO:0045944	F:protein homodimerization activity
GO:0046332	P:cell fate commitment
GO:0046872	P:negative regulation of transcription
GO:0046982	DNA-templated
GO:0048156	P:positive regulation of transcription
GO:0048340	DNA-templated
GO:0048617	P:positive regulation of transcription by RNA polymerase II
GO:0048701	F:SMAD binding
GO:0051098	F:metal ion binding
GO:0060039	F:protein heterodimerization activity
GO:0060395	F:tau protein binding
GO:0062009	P:paraxial mesoderm morphogenesis
GO:0070410	P:embryonic foregut morphogenesis
GO:0070411	P:embryonic cranial skeleton morphogenesis
GO:0070412	P:regulation of binding
GO:0070723	P:pericardium development
GO:0070878	P:SMAD protein signal transduction
GO:0071141	P:secondary palate development
GO:0071144	F:co-SMAD binding
GO:0097718	F:I-SMAD binding
GO:1900224	F:R-SMAD binding

KEGG Pathway
Reactome Pathway

Pathway ID	Pathway Name	Pathway Description (KEGG)
hsa04068	FoxO signaling pathway	The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
hsa04110	Cell cycle	Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
hsa04144	Endocytosis	Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
hsa04218	Cellular senescence	Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
hsa04350	TGF-beta signaling pathway	The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
hsa04371	Apelin signaling pathway	Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, cell proliferation and energy metabolism regulation. On the other hand, this ligand receptor couple is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer.
hsa04390	Hippo signaling pathway	Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor Salvador and LATS1 and LATS2. In response to high cell densities, activated LATS1/2 phosphorylates the transcriptional coactivators YAP and TAZ, promoting its cytoplasmic localization, leading to cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated at low cell density, YAP/TAZ translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. YAP/TAZ also interacts with other transcriptional factors or signaling molecules, by which Hippo pathway-mediated processes are interconnected with those of other key signaling cascades, such as those mediated by TGF-beta and Wnt growth factors.
hsa04520	Adherens junction	Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
hsa04550	Signaling pathways regulating pluripotency of stem cells	Pluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date include embryonic stem (ES) and induced pluripotent stem (iPS) cells. ES cells are derived from the inner cell mass (ICM) of blastocyst-stage embryos. iPS cells are generated by reprogramming somatic cells back to pluripotent state with defined reprogramming factors, Oct4, Sox2, Klf4 and c-Myc (also known as Yamanaka factors). PSCs including ES cells and iPS cells are categorized into two groups by their morphology, gene expression profile and external signal dependence. Conventional mouse-type ES/iPS cells are called 'naive state' cells. They are mainly maintained under the control of LIF and BMP signaling. On the other hand, human-type ES/iPS cells, which are in need of Activin and FGF signaling, are termed 'primed state'. However, these signaling pathways converge towards the activation of a core transcriptional network that is similar in both groups and involves OCt4, Nanog and Sox2. The three transcription factors and their downstream target genes coordinately promote self-renewal and pluripotency.
hsa04659	Th17 cell differentiation	Interleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the pathogenesis of autoimmune diseases. In vivo, Th17 differentiation requires antigen presentation and co-stimulation, and activation of antigen presenting-cells (APCs) to produce TGF-beta, IL-6, IL-1, IL-23 and IL-21. This initial activation results in the activation and up-regulation of STAT3, ROR(gamma)t and other transcriptional factors in CD4+ T cells, which bind to the promoter regions of the IL-17, IL-21 and IL-22 genes and induce IL-17, IL-21 and IL-22. In contrast, the differentiation of Th17 cells and their IL-17 expression are negatively regulated by IL-2, Th2 cytokine IL-4, IL-27 and Th1 cytokine IFN-gamma through STAT5, STAT6 and STAT1 activation, respectively. Retinoid acid and the combination of IL-2 and TGF-beta upregulate Foxp3, which also downregulates cytokines like IL-17 and IL-21. The inhibition of Th17 differentiation may serve as a protective strategy to 'fine-tune' the expression IL-17 so it does not cause excessive inflammation. Thus, balanced differentiation of Th cells is crucial for immunity and host protection.
hsa04926	Relaxin signaling pathway	Human relaxin-2 (relaxin), originally identified as a peptidic hormone of pregnancy, is now known to exert a range of pleiotropic effects including vasodilatory, anti-fibrotic and angiogenic effects in both males and females. It belongs to the so-called relaxin peptide family which includes the insulin-like peptides INSL3 and INSL5, and relaxin-3 (H3) as well as relaxin. INSL3 has clearly defined specialist roles in male and female reproduction, relaxin-3 is primarily a neuropeptide involved in stress and metabolic control, and INSL5 is widely distributed particularly in the gastrointestinal tract. These members of relaxin peptide family exert such effects binding to different kinds of receptors, classified as relaxin family peptide (RXFP) receptors: RXFP1, RXFP2, RXFP3, and RXFP4. These G protein-coupled receptors predominantly bind relaxin, INSL3, relaxin-3, and INSL-5, respectively. RXFP1 activates a wide spectrum of signaling pathways to generate second messengers that include cAMP and nitric oxide, whereas RXFP2 activates a subset of these pathways. Both RXFP3 and RXFP4 inhibit cAMP production, and RXFP3 activate MAP kinases.
hsa04933	AGE-RAGE signaling pathway in diabetic complications	Advanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and under certain pathologic condition such as huperglycemia. Some of the best chemically characterized AGEs include N-epsilon-carboxy-methyl-lysine (CML), N-epsilon-carboxy-ethyl-lysine (CEL), and Imidazolone. The major receptor for AGEs, known as receptor for advanced glycation end products (RAGE or AGER), belongs to the immunoglobulin superfamily and has been described as a pattern recognition receptor. AGE/RAGE signaling elicits activation of multiple intracellular signal pathways involving NADPH oxidase, protein kinase C, and MAPKs, then resulting in NF-kappaB activity. NF-kappa B promotes the expression of pro-inflammatory cytokines such as IL-1, IL-6 and TNF-alpha and a variety of atherosclerosis-related genes, including VCAM-1, tissue factor, VEGF, and RAGE. In addition, JAK-STAT-mediated and PI3K-Akt-dependent pathways are induced via RAGE, which in turn participate in cell proliferation and apoptosis respectively. Hypoxia-mediated induction of Egr-1 was also shown to require the AGE-RAGE interaction. The results of these signal transductions have been reported to be the possible mechanism that initates diabetic complications.
hsa05142	Chagas disease (American trypanosomiasis)	Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they invade diverse host cells including cardiomyocytes. Establishment of infection depends on various parasite molecules such as cruzipain, oligopeptidase B, and trans-sialidase that activate Ca2+ signaling. Internalized parasites escape from the parasitophorous vacuole using secreted pore-forming TcTOX molecule and replicate in the cytosol. Multiplied parasites eventually lyse infected host cells and are released in the circulation. During these events, the parasites manipulate host innate immunity and elicit cardiomyocyte hypertrophy. T lymphocyte responses are also disturbed.
hsa05166	Human T-cell leukemia virus 1 infection	Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, SRF, and NFAT.
hsa05200	Pathways in cancer
hsa05205	Proteoglycans in cancer	Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR: 00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
hsa05210	Colorectal cancer	Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined oncogenes and tumour suppressor genes (TSG). Two major mechanisms of genomic instability have been identified in sporadic CRC progression. The first, known as chromosomal instability (CIN), results from a series of genetic changes that involve the activation of oncogenes such as K-ras and inactivation of TSG such as p53, DCC/Smad4, and APC. The second, known as microsatellite instability (MSI), results from inactivation of the DNA mismatch repair genes MLH1 and/or MSH2 by hypermethylation of their promoter, and secondary mutation of genes with coding microsatellites, such as transforming growth factor receptor II (TGF-RII) and BAX. Hereditary syndromes have germline mutations in specific genes (mutation in the tumour suppressor gene APC on chromosome 5q in FAP, mutated DNA mismatch repair genes in HNPCC).
hsa05212	Pancreatic cancer	Infiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA). Normal duct epithelium progresses to infiltrating cancer through a series of histologically defined precursors (PanINs). The overexpression of HER-2/neu and activating point mutations in the K-ras gene occur early, inactivation of the p16 gene at an intermediate stage, and the inactivation of p53, SMAD4, and BRCA2 occur relatively late. Activated K-ras engages multiple effector pathways. Although EGF receptors are conventionally regarded as upstream activators of RAS proteins, they can also act as RAS signal transducers via RAS-induced autocrine activation of the EGFR family ligands. Moreover, PDA shows extensive genomic instability and aneuploidy. Telomere attrition and mutations in p53 and BRCA2 are likely to contribute to these phenotypes. Inactivation of the SMAD4 tumour suppressor gene leads to loss of the inhibitory influence of the transforming growth factor-beta signalling pathway.
hsa05225	Hepatocellular carcinoma	Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.
hsa05226	Gastric cancer	Gastric cancer (GC) is one of the world's most common cancers. According to Lauren's histological classification gastric cancer is divided into two distinct histological groups - the intestinal and diffuse types. Several genetic changes have been identified in intestinal-type GC. The intestinal metaplasia is characterized by mutations in p53 gene, reduced expression of retinoic acid receptor beta (RAR-beta) and hTERT expression. Gastric adenomas furthermore display mutations in the APC gene, reduced p27 expression and cyclin E amplification. In addition, amplification and overexpression of c-ErbB2, reduced TGF-beta receptor type I (TGFBRI) expression and complete loss of p27 expression are commonly observed in more advanced GC. The main molecular changes observed in diffuse-type GCs include loss of E-cadherin function by mutations in CDH1 and amplification of MET and FGFR2F.
hsa05321	Inflammatory bowel disease (IBD)	Inflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and genetic factors, infectious microbes, and the dysregulated immune system. Although many environmental factors (for example, geographic locations, smoking, etc.) affect the development of IBD, the most crucial might be the luminal (external) environment of the epithelial cells. There are pathogens that are found in increasing frequency in IBD. The microbial components such as flagellin, peptidoglycan, and lipopolysaccharide are recognized by receptors such as toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD) proteins, and also by antigen-presenting cells (APCs) in genetically susceptible host. The TLR recognition triggers the activation of NF-kappaB, leading to an inflammatory response. APC-expressed gene NOD2 has been associated with Crohn disease. In case of mutations of NOD2, negative regulation of IL-12 production is reduced with the stimulation of muramyl dipeptide (MDP), leading to CD. In addition, the APC mediates the differentiation of naive T cells into effector T cells (Th1, Th17, Th2) and natural killer T (NKT) cells. Th1 and Th17 cells produce high levels of IFN-gamma and IL-17, -22, respectively, both of which promote CD. In contrast, Th2 cells produce IL-4, -5, -10, which together with IL-13 from NKT induce UC.

Pathway ID	Pathway Name	Pathway Description (KEGG)
R-HSA-1181150	Signaling by NODAL.	Signaling by NODAL is essential for patterning of the axes of the embryo and formation of mesoderm and endoderm (reviewed in Schier 2009, Shen 2007). The NODAL proprotein is secreted and cleaved extracellularly to yield mature NODAL. Mature NODAL homodimerizes and can also form heterodimers with LEFTY1, LEFTY2, or CERBERUS, which negatively regulate NODAL signaling. NODAL also forms heterodimers with GDF1, which increases NODAL activity. NODAL dimers bind the NODAL receptor comprising a type I Activin receptor (ACVR1B or ACVR1C), a type II Activin receptor (ACVR2A or ACVR2B), and an EGF-CFC coreceptor (CRIPTO or CRYPTIC). After binding NODAL, the type II activin receptor phosphorylates the type I activin receptor which then phosphorylates SMAD2 and SMAD3 (R-SMADs). Phosphorylated SMAD2 and SMAD3 form hetero-oligomeric complexes with SMAD4 (CO-SMAD) and transit from the cytosol to the nucleus. Within the nucleus the SMAD complexes interact with transcription factors such as FOXH1 to activate transcription of target genes
R-HSA-1502540	Signaling by Activin.	Activin was initially discovered as an activator of follicle stimulating hormone in the pituitary gland. It has since been shown to be an important participant in the differentiation of embryonic cells into mesodermal and endodermal layers. Activin binds the Activin receptor and triggers downstream events: phosphorylation of SMAD2 and SMAD3 followed by activation of gene expression (reviewed in Attisano et al. 1996, Willis et al. 1996, Chen et al. 2006, Hinck 2012). Activins are dimers comprising activin A (INHBA:INHBA), activin AB (INHBA:INHBB), and activin B (INHBB:INHBB). Activin first binds the type II receptor (ACVR2A, ACVR2B) and this complex then interacts with the type I receptor (ACVR1B, ACVR1C) (Attisano et al. 1996). The type II receptor phosphorylates the type I receptor and then the phosphorylated type I receptor phosphorylates SMAD2 and SMAD3. Dimers of phosphorylated SMAD2/3 bind SMAD4 and the resulting ternary complex enters the nucleus and activates target genes
R-HSA-2173788	Downregulation of TGF-beta receptor signaling.	TGF-beta receptor signaling is downregulated by proteasome and lysosome-mediated degradation of ubiquitinated TGFBR1, SMAD2 and SMAD3, as well as by dephosphorylation of TGFBR1, SMAD2 and SMAD3. In the nucleus, SMAD2/3:SMAD4 complex stimulates transcription of SMAD7, an inhibitory SMAD (I-SMAD). SMAD7 binds phosphorylated TGFBR1 and competes with the binding of SMAD2 and SMAD3 (Hayashi et al. 1997, Nakao et al. 1997). Binding of SMAD7 to TGBR1 can be stabilized by STRAP, a protein that simultaneously binds SMAD7 and TGFBR1 (Datta et al. 2000). BAMBI simultaneously binds SMAD7 and activated TGFBR1, leading to downregulation of TGF-beta receptor complex signaling (Onichtchouk et al. 1999, Yan et al. 2009). In addition to competing with SMAD2/3 binding to TGFBR1, SMAD7 recruits protein phosphatase PP1 to phosphorylated TGFBR1, by binding to the PP1 regulatory subunit PPP1R15A (GADD34). PP1 dephosphorylates TGFBR1, preventing the activation of SMAD2/3 and propagation of TGF-beta signal (Shi et al. 2004). SMAD7 associates with several ubiquitin ligases, SMURF1 (Ebisawa et al. 2001, Suzuki et al. 2002, Tajima et al. 2003, Chong et al. 2010), SMURF2 (Kavsak et al. 2000, Ogunjimi et al. 2005), and NEDD4L (Kuratomi et al. 2005), and recruits them to phosphorylated TGFBR1 within TGFBR complex. SMURF1, SMURF2 and NEDD4L ubiquitinate TGFBR1 (and SMAD7), targeting TGFBR complex for proteasome and lysosome-dependent degradation (Ebisawa et al. 2001, Kavsak et al. 2000, Kuratomi et al. 2005). The ubiquitination of TGFBR1 can be reversed by deubiquitinating enzymes, UCHL5 (UCH37) and USP15, which may be recruited to ubiquitinated TGFBR1 by SMAD7 (Wicks et al. 2005, Eichhorn et al. 2012). Basal levels of SMAD2 and SMAD3 are maintained by SMURF2 and STUB1 ubiquitin ligases. SMURF2 is able to bind and ubiquitinate SMAD2, leading to SMAD2 degradation (Zhang et al. 2001), but this has been questioned by a recent study of Smurf2 knockout mice (Tang et al. 2011). STUB1 (CHIP) binds and ubiquitinates SMAD3, leading to SMAD3 degradation (Li et al. 2004, Xin et al. 2005). PMEPA1 can bind and sequester unphosphorylated SMAD2 and SMAD3, preventing their activation in response to TGF-beta signaling. In addition, PMEPA1 can bind and sequester phosphorylated SMAD2 and SMAD3, preventing formation of SMAD2/3:SMAD4 heterotrimer complexes (Watanabe et al. 2010). A protein phosphatase MTMR4, residing in the membrane of early endosomes, can dephosphorylate activated SMAD2 and SMAD3, preventing formation of SMAD2/3:SMAD4 complexes (Yu et al. 2010)
R-HSA-2173789	TGF-beta receptor signaling activates SMADs.	Binding of transforming growth factor beta 1 (TGF beta 1, i.e. TGFB1) to TGF beta receptor type 2 (TGFBR2) activates TGF beta receptor signaling cascade. TGFB1 is posttranslationally processed by furin (Dubois et al. 1995) to form a homodimer and secreted to the extracellular space as part of the large latent complex (LLC). After the LLC disassembles in the extracellular space, dimeric TGFB1 becomes capable of binding to TGFBR2 (Annes et al. 2003, Keski Oja et al. 2004). Formation of TGFB1:TGFBR2 complex creates a binding pocket for TGF-beta receptor type-1 (TGFBR1) and TGFBR1 is recruited to the complex by binding to both TGFB1 and TGFBR2. This results in an active heterotetrameric TGF-beta receptor complex that consists of TGFB1 homodimer bound to two heterodimers of TGFBR1 and TGFBR2 (Wrana et al. 1992, Moustakas et al. 1993, Franzen et al. 1993). TGF-beta signaling can also occur through a single heterodimer of TGFBR1 and TGFBR2, although with decreased efficiency (Huang et al. 2011). TGFBR1 and TGFBR2 interact through their extracellular domains, which brings their cytoplasmic domains together. Ligand binding to extracellular receptor domains is cooperative, but no conformational change is seen from crystal structures of either TGFB1- or TGFB3-bound heterotetrameric receptor complexes (Groppe et al. 2008, Radaev et al. 2010).Activation of TGFBR1 by TGFBR2 in the absence of ligand is prevented by FKBP1A (FKBP12), a peptidyl-prolyl cis-trans isomerase. FKBP1A forms a complex with inactive TGFBR1 and dissociates from it only after TGFBR1 is recruited by TGFB1-bound TGFBR2 (Chen et al. 1997). Both TGFBR1 and TGFBR2 are receptor serine/threonine kinases. Formation of the hetero-tetrameric TGF-beta receptor complex (TGFBR) in response to TGFB1 binding induces receptor rotation, so that TGFBR2 and TGFBR1 cytoplasmic kinase domains face each other in a catalytically favourable configuration. TGFBR2 trans-phosphorylates serine residues at the conserved Gly-Ser-rich juxtapositioned domain (GS domain) of TGFBR1 (Wrana et al. 1994, Souchelnytskyi et al. 1996), activating TGFBR1.In addition to phosphorylation, TGFBR1 may also be sumoylated in response to TGF-beta stimulation. Sumoylation enhances TGFBR1 kinase activity (Kang et al. 2008). The activated TGFBR complex is internalized by clathrin-mediated endocytosis into early endosomes. With the assistance of SARA, an early endosome membrane protein, phosphorylated TGFBR1 within TGFBR complex recruits SMAD2 and/or SMAD3 , i.e. R-SMADs (Tsukazaki et al. 1998). TGFBR1 phosphorylates recruited SMAD2/3 on two C-terminal serine residues (Souchelnytskyi et al. 2001). The phosphorylation changes the conformation of SMAD2/3 MH2 domain, promoting dissociation of SMAD2/3 from SARA and TGFBR1 (Souchelnytskyi et al. 1997, Macias-Silva et al. 1996, Nakao et al. 1997) and formation of SMAD2/3 trimers (Chacko et al. 2004). The phosphorylated C-terminal tail of SMAD2/3 has high affinity for SMAD4 (Co-SMAD), inducing formation of SMAD2/3:SMAD4 heterotrimers, composed of two phosphorylated R-SMADs (SMAD2 and/or SMAD3) and SMAD4 (Co-SMAD). SMAD2/3:SMAD4 heterotrimers are energetically favored over R-SMAD trimers (Nakao et al. 1997, Qin et al. 2001, Kawabata et al. 1998, Chacko et al. 2004). SMAD2/3:SMAD4 heterotrimers translocate to the nucleus where they act as transcriptional regulators
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity.	Transcriptional activity of SMAD2/3:SMAD4 heterotrimer can be inhibited by formation of a complex with SKI or SKIL (SNO), where SKI or SKIL recruit NCOR and possibly other transcriptional repressors to SMAD-binding promoter elements (Sun et al. 1999, Luo et al. 1999, Strochein et al. 1999). Higher levels of phosphorylated SMAD2 and SMAD3, however, may target SKI and SKIL for degradation (Strochein et al. 1999, Sun et al. 1999 PNAS, Bonni et al. 2001) through recruitment of SMURF2 (Bonni et al. 2001) or RNF111 i.e. Arkadia (Levy et al. 2007) ubiquitin ligases to SKI/SKIL by SMAD2/3. Therefore,the ratio of SMAD2/3 and SKI/SKIL determines the outcome: inhibition of SMAD2/3:SMAD4-mediated transcription or degradation of SKI/SKIL. SKI and SKIL are overexpressed in various cancer types and their oncogenic effect is connected with their ability to inhibit signaling by TGF-beta receptor complex. SMAD4 can be monoubiquitinated by a nuclear ubiquitin ligase TRIM33 (Ecto, Ectodermin, Tif1-gamma). Monoubiquitination of SMAD4 disrupts SMAD2/3:SMAD4 heterotrimers and leads to SMAD4 translocation to the cytosol. In the cytosol, SMAD4 can be deubiquitinated by USP9X (FAM), reversing TRIM33-mediated negative regulation (Dupont et al. 2009).Phosphorylation of the linker region of SMAD2 and SMAD3 by CDK8 or CDK9 primes SMAD2/3:SMAD4 complex for ubiquitination by NEDD4L and SMURF ubiquitin ligases. NEDD4L ubiquitinates SMAD2/3 and targets SMAD2/3:SMAD4 heterotrimer for degradation (Gao et al. 2009). SMURF2 monoubiquitinates SMAD2/3, leading to disruption of SMAD2/3:SMAD4 complexes (Tang et al. 2011). Transcriptional repressors TGIF1 and TGIF2 bind SMAD2/3:SMAD4 complexes and inhibit SMAD-mediated transcription by recruitment of histone deacetylase HDAC1 to SMAD-binding promoter elements (Wotton et al. 1999, Melhuish et al. 2001).PARP1 can attach poly ADP-ribosyl chains to SMAD3 and SMAD4 within SMAD2/3:SMAD4 heterotrimers. PARylated SMAD2/3:SMAD4 complexes are unable to bind SMAD-binding DNA elements (SBEs) (Lonn et al. 2010). Phosphorylated SMAD2 and SMAD3 can be dephosphorylated by PPM1A protein phosphatase, leading to dissociation of SMAD2/3 complexes and translocation of unphosphorylated SMAD2/3 to the cytosol (Lin et al. 2006)
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.	After phosphorylated SMAD2 and/or SMAD3 form a heterotrimer with SMAD4, SMAD2/3:SMAD4 complex translocates to the nucleus (Xu et al. 2000, Kurisaki et al. 2001, Xiao et al. 2003). In the nucleus, linker regions of SMAD2 and SMAD3 within SMAD2/3:SMAD4 complex can be phosphorylated by CDK8 associated with cyclin C (CDK8:CCNC) or CDK9 associated with cyclin T (CDK9:CCNT). CDK8/CDK9-mediated phosphorylation of SMAD2/3 enhances transcriptional activity of SMAD2/3:SMAD4 complex, but also primes it for ubiquitination and consequent degradation (Alarcon et al. 2009). The transfer of SMAD2/3:SMAD4 complex to the nucleus can be assisted by other proteins, such as WWTR1. In human embryonic cells, WWTR1 (TAZ) binds SMAD2/3:SMAD4 heterotrimer and mediates TGF-beta-dependent nuclear accumulation of SMAD2/3:SMAD4. The complex of WWTR1 and SMAD2/3:SMAD4 binds promoters of SMAD7 and SERPINE1 (PAI-1 i.e. plasminogen activator inhibitor 1) genes and stimulates their transcription (Varelas et al. 2008). Stimulation of SMAD7 transcription by SMAD2/3:SMAD4 represents a negative feedback loop in TGF-beta receptor signaling. SMAD7 can be downregulated by RNF111 ubiquitin ligase (Arkadia), which binds and ubiquitinates SMAD7, targeting it for degradation (Koinuma et al. 2003). SMAD2/3:SMAD4 heterotrimer also binds the complex of RBL1 (p107), E2F4/5 and TFDP1/2 (DP1/2). The resulting complex binds MYC promoter and inhibits MYC transcription. Inhibition of MYC transcription contributes to anti-proliferative effect of TGF-beta (Chen et al. 2002). SMAD2/3:SMAD4 heterotrimer also associates with transcription factor SP1. SMAD2/3:SMAD4:SP1 complex stimulates transcription of a CDK inhibitor CDKN2B (p15-INK4B), also contributing to the anti-proliferative effect of TGF-beta (Feng et al. 2000). MEN1 (menin), a transcription factor tumor suppressor mutated in a familial cancer syndrome multiple endocrine neoplasia type 1, forms a complex with SMAD2/3:SMAD4 heterotrimer, but transcriptional targets of SMAD2/3:SMAD4:MEN1 have not been elucidated (Kaji et al. 2001, Sowa et al. 2004, Canaff et al. 2012). JUNB is also an established transcriptional target of SMAD2/3:SMAD4 complex (Wong et al. 1999)
R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer.	The conserved phosphorylation motif Ser-Ser-X-Ser at the C-terminus of SMAD2 and SMAD3 is subject to disruptive mutations in cancer. The last two serine residues in this conserved motif, namely Ser465 and Ser467 in SMAD2 and Ser423 and Ser425 in SMAD3, are phosphorylated by the activated TGF beta receptor complex (Macias Silva et al. 1996, Nakao et al. 1997). Once phosphorylated, SMAD2 and SMAD3 form transcriptionally active heterotrimers with SMAD4 (Chacko et al. 2001, Chacko et al. 2004). Phosphorylation motif mutants of SMAD2 and SMAD3 cannot be activated by the TGF-beta receptor complex either because serine residues are substituted with amino acid residues that cannot be phosphorylated or because the phosphorylation motif is deleted from the protein sequence or truncated (Fleming et al. 2013)
R-HSA-3311021	SMAD4 MH2 Domain Mutants in Cancer.	The MH2 domain of SMAD4 is the most frequently mutated SMAD4 region in cancer. MH2 domain mutations result in the loss of function of SMAD4 by abrogating the formation of transcriptionally active heterotrimers of SMAD4 and TGF-beta receptor complex-activated R-SMADs - SMAD2 and SMAD3 (Shi et al. 1997, Chacko et al. 2001, Chacko et al. 2004, Fleming et al. 2013).The hotspot MH2 domain amino acid residues that are targeted by missense mutations are Asp351 (D351), Pro356 (P356) and Arg361 (R361). These three hotspot residues map to the L1 loop which is conserved in SMAD2 and SMAD3 and is involved in intermolecular interactions that contribute to the formation of SMAD heterotrimers and homotrimers (Shi et al. 1997, Fleming et al. 2013). Other frequently mutated residues in the MH2 domain of SMAD4 - Ala406 (A406), Lys428 (K428) and Arg515 (R515) - are involved in binding the phosphorylation motif (Ser-Ser-X-Ser) of SMAD2 and SMAD3, with Arg515 in the L3 loop being critical for this interaction (Chacko et al. 2001, Chacko et al. 2004, Fleming et al. 2013)
R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer.	Mutations in the MH2 domain of SMAD2 and SMAD3 affect their ability to form heterotrimers with SMAD4, thereby impairing TGF-beta signaling (Fleming et al. 2013).The SMAD2 and SMAD3 MH2 domain residues most frequently targeted by missense mutations are those that are homologous to SMAD4 MH2 domain residues shown to be involved in the formation of SMAD heterotrimers. Asp300 of SMAD2 and Asp258 of SMAD3 correspond to the frequently mutated Asp351 of SMAD4. Pro305 of SMAD2 corresponds to the frequently mutated Pro356 of SMAD4, while Ala354 of SMAD2 corresponds to Ala406 of SMAD4. Arg268 of SMAD3 corresponds to the frequently mutated Arg361 of SMAD4. SMAD2 and SMAD3 MH2 domain mutations have been examined in most detail in colorectal cancer (Fleming et al. 2013)
R-HSA-3656532	TGFBR1 KD Mutants in Cancer.	Mutations in the kinase domain (KD) of TGF-beta receptor 1 (TGFBR1) have been found in Ferguson-Smith tumor i.e. multiple self-healing squamous epithelioma - MSSE (Goudie et al. 2011), breast cancer (Chen et al. 1998), ovarian cancer (Chen et al. 2001) and head-and-neck cancer (Chen et al. 2001). KD mutations reported in MSSE are nonsense and frameshift mutations that cause premature termination of TGFBR1 translation, resulting in truncated receptors that lack substantial portions of the kinase domain, or cause nonsense-mediated decay of mutant transcripts. A splice site KD mutation c.806-2A>C is predicted to result in the skipping of exon 5 and the absence of KD amino acid residues 269-324 from the mutant receptor. The splice site mutant is expressed at the cell surface but unresponsive to TGF-beta stimulation (Goudie et al. 2004).TGFBR1 KD mutations reported in breast, ovarian and head-and-neck cancer are missense mutations, and it appears that these mutant proteins are partially functional but that their catalytic activity or protein stability is decreased (Chen et al. 1998, Chen et al. 2001a and b). These mutants are not shown
R-HSA-452723	Transcriptional regulation of pluripotent stem cells.	Pluripotent stem cells are undifferentiated cells posessing an abbreviated cell cycle (reviewed in Stein et al. 2012), a characteristic profile of gene expression (Rao et al. 2004, Kim et al. 2006, Player et al. 2006, Wang et al 2006 using mouse, International Stem Cell Initiative 2007, Assou et al. 2007, Assou et al. 2009, Ding et al. 2012 using mouse), and the ability to self-renew and generate all cell types of the body except extraembryonic lineages (Marti et al. 2013, reviewed in Romeo et al. 2012). They are a major cell type in the inner cell mass of the early embryo in vivo, and cells with the same properties, induced pluripotent stem cells, can be generated in vitro from differentiated adult cells by overexpression of a set of transcription factor genes (Takahashi and Yamanaka 2006, Takahashi et al. 2007, Yu et al. 2007, Jaenisch and Young 2008, Stein et al. 2012, reviewed in Dejosez and Zwaka 2012).Pluripotency is maintained by a self-reinforcing loop of transcription factors (Boyer et al. 2005, Rao et al. 2006, Matoba et al. 2006, Player et al. 2006, Babaie et al. 2007, Sun et al. 2008, Assou et al. 2009, reviewed in Kashyap et al. 2009, reviewed in Dejosez and Zwaka 2012). In vivo, initiation of pluripotency may depend on maternal factors transmitted through the oocyte (Assou et al. 2009) and on DNA demethylation in the zygote (recently reviewed in Seisenberger et al. 2013) and hypoxia experienced by the blastocyst in the reproductive tract before implantation (Forristal et al. 2010, reviewed in Mohyeldin et al. 2010). In vitro, induced pluripotency may initiate with demethylation and activation of the promoters of POU5F1 (OCT4) and NANOG (Bhutani et al. 2010). Hypoxia also significantly enhances conversion to pluripotent stem cells (Yoshida et al. 2009). POU5F1 and NANOG, together with SOX2, encode central factors in pluripotency and activate their own transcription (Boyer et al 2005, Babaie et al. 2007, Yu et al. 2007, Takahashi et al. 2007). The autoactivation loop maintains expression of POU5F1, NANOG, and SOX2 at high levels in stem cells and, in turn, complexes containing various combinations of these factors (Remenyi et al. 2003, Lam et al. 2012) activate the expression of a group of genes whose products are associated with rapid cell proliferation and repress the expression of a group of genes whose products are associated with cell differentiation (Boyer et al. 2005, Matoba et al. 2006, Babaie et al. 2007, Chavez et al. 2009, Forristal et al. 2010, Guenther 2011).Comparisons between human and mouse embryonic stem cells must be made with caution and for this reason inferences from mouse have been used sparingly in this module. Human ESCs more closely resemble mouse epiblast stem cells in having inactivated X chromosomes, flattened morphology, and intolerance to passaging as single cells (Hanna et al. 2010). Molecularly, human ESCs differ from mouse ESCs in being maintained by FGF and Activin/Nodal/TGFbeta signaling rather than by LIF and canonical Wnt signaling (Greber et al. 2010, reviewed in Katoh 2011). In human ESCs POU5F1 binds and directly activates the FGF2 gene, however Pou5f1 does not activate Fgf2 in mouse ESCs (reviewed in De Los Angeles et al. 2012). Differences in expression patterns of KLF2, KLF4, KLF5, ESRRB, FOXD3, SOCS3, LIN28, NODAL were observed between human and mouse ESCs (Cai et al. 2010) as were differences in expression of EOMES, ARNT and several other genes (Ginis et al.2004)
R-HSA-5689880	Ub-specific processing proteases.	Ub-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved motifs with N- or C-terminal extensions and insertions occurring between the conserved motifs (Ye et al. 2009). Two highly conserved regions comprise the catalytic triad, the Cys-box (Cys) and His-box (His and Asp/Asn) (Nijman et al. 2005, Ye et al. 2009, Reyes-Turcu & Wilkinson 2009). They recognize their substrates by interactions of the variable regions with the substrate protein directly, or via scaffolds or adapters in multiprotein complexes

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Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
ACVR1B	Affinity Capture-Western	physical	9892009, (Europe PMC)	NA	BioGRID
ACVR2B	Affinity Capture-Western	physical	11094085, (Europe PMC)	NA	BioGRID
AFDN	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
AKT1	Affinity Capture-Western, two hybrid array	physical, physical association	16362038, 24412244, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ANAPC10	Affinity Capture-Western, Reconstituted Complex	physical	15144564, (Europe PMC)	NA	BioGRID
ANAPC2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ANK3	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
ANP32B	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
ANP32E	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
ANTXR2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ARID1A	Affinity Capture-MS	physical	18003620, (Europe PMC)	NA	BioGRID
ARID1B	Affinity Capture-MS	physical	16751102, (Europe PMC)	NA	BioGRID
ATAD3B	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
ATF3	Affinity Capture-Western	physical	20930144, (Europe PMC)	NA	BioGRID
ATP5ME	Reconstituted Complex	physical	20195357, (Europe PMC)	NA	BioGRID
BAZ1A	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
BPTF	Reconstituted Complex	physical	18974875, (Europe PMC)	NA	BioGRID
BRCA2	Affinity Capture-Western	physical	12165866, (Europe PMC)	NA	BioGRID
BTBD2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
BUB3	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
C1orf116	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
C22orf46	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
CAD	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
CAMK2A	Co-localization, proximity ligation assay	physical, physical association	25241761, (Europe PMC)	0.40	BioGRID, IntAct
CAMK2G	Biochemical Activity	physical	11027280, (Europe PMC)	NA	BioGRID
CAV1	Co-fractionation	physical	11102446, (Europe PMC)	NA	BioGRID
CCT6A	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
CDC16	Affinity Capture-Western	physical	11691834, (Europe PMC)	NA	BioGRID
CDC27	Affinity Capture-Western	physical	11691834, (Europe PMC)	NA	BioGRID
CDK2	Biochemical Activity	physical	15241418, (Europe PMC)	NA	BioGRID
CDK4	Biochemical Activity	physical	15241418, (Europe PMC)	NA	BioGRID
CDK8	Biochemical Activity	physical	19914168, (Europe PMC)	NA	BioGRID
CDK9	Biochemical Activity	physical	19914168, (Europe PMC)	NA	BioGRID
CHUK	Affinity Capture-Western, anti tag coimmunoprecipitation, pull down	physical, physical association	18268325, (Europe PMC)	0.52	BioGRID, IntAct
CISH	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CITED2	Affinity Capture-Western	physical	16619037, (Europe PMC)	NA	BioGRID
COPS5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CPSF7	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
CREBBP	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	15231748, 15750622, 16751102, 17283070, 18003620, 20403362, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CSH1	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
CSH2	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
CSNK1D	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, tandem affinity purification	physical, physical association	18729074, 19139564, (Europe PMC)	0.40	BioGRID, IntAct
CTNNB1	Affinity Capture-Western	physical	12000714, 20571128, (Europe PMC)	NA	BioGRID
CUL5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CYP11A1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DAB2	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down	physical, physical association	11387212, (Europe PMC)	0.52	BioGRID, IntAct
DCAF7	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
DCUN1D1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DDX3Y	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
DGKA	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
DHX8	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
DNAJA2	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
DNAJC7	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DOCK8	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DOCK9	Affinity Capture-MS, Affinity Capture-Western	physical	18729074, (Europe PMC)	NA	BioGRID
DVL1	Reconstituted Complex	physical	12650946, (Europe PMC)	NA	BioGRID
DYNC1H1	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
EEF1A1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
EID2	Affinity Capture-Western	physical	14612439, (Europe PMC)	NA	BioGRID
EIF3L	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
ELAC2	Affinity Capture-Western, Reconstituted Complex	physical	16636667, (Europe PMC)	NA	BioGRID
ELAVL1	Affinity Capture-RNA	physical	19322201, (Europe PMC)	NA	BioGRID
EP300	Affinity Capture-Western, Two-hybrid, two hybrid	physical, physical association	10199400, 11371641, 12237408, 15623506, 21988832, (Europe PMC)	0.37	BioGRID, IntAct
EPB41L5	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
ERBIN	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex	physical	12650946, 17591701, 18003620, 18729074, (Europe PMC)	NA	BioGRID
ESR1	Affinity Capture-Western, Reconstituted Complex	physical	11555647, 20207742, (Europe PMC)	NA	BioGRID
ETV4	Affinity Capture-Western, Two-hybrid	physical	21613609, (Europe PMC)	NA	BioGRID
FAM161B	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
FAM83G	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
FHL1	Affinity Capture-Western, Reconstituted Complex	physical	19139564, (Europe PMC)	NA	BioGRID
FHL2	Affinity Capture-Western, Reconstituted Complex	physical	19139564, (Europe PMC)	NA	BioGRID
FHL3	Affinity Capture-Western, Reconstituted Complex	physical	19139564, (Europe PMC)	NA	BioGRID
FOXH1	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, affinity technology, two hybrid array, two hybrid prey pooling approach	physical, physical association	10199400, 10938097, 12732634, 15750622, 16916642, 21828274, 9288972, 9389648, 9702198, 9858566, (Europe PMC)	0.63	BioGRID, IntAct
GATAD2B	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
GFER	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
GLI1	Affinity Capture-Western	physical	24739390, (Europe PMC)	NA	BioGRID
GTF2I	Affinity Capture-Western	physical	16055724, (Europe PMC)	NA	BioGRID
GTF2IRD1	Affinity Capture-Western	physical	16055724, (Europe PMC)	NA	BioGRID
HDAC1	Affinity Capture-Western	physical	10199400, 11226163, 14699069, (Europe PMC)	NA	BioGRID
HDAC2	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
HGS	Affinity Capture-Western	physical	11094085, (Europe PMC)	NA	BioGRID
HIPK2	Reconstituted Complex	physical	12874272, (Europe PMC)	NA	BioGRID
HSPA4	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
ING2	Affinity Capture-Western	physical	18334480, (Europe PMC)	NA	BioGRID
INSR	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	9092546, (Europe PMC)	NA	BioGRID
IRF3	Affinity Capture-Western	physical	14729983, (Europe PMC)	NA	BioGRID
IRF7	Affinity Capture-Western, Reconstituted Complex	physical	14729983, (Europe PMC)	NA	BioGRID
ITCH	Affinity Capture-Western, Biochemical Activity	physical	15350225, (Europe PMC)	NA	BioGRID
ITGB4	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
JUN	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, display technology	association, physical, physical association	11371641, 20195357, 25609649, (Europe PMC)	0.56	BioGRID, IntAct, MINT
KAT2A	Affinity Capture-Western	physical	15009097, (Europe PMC)	NA	BioGRID
KAT2B	Affinity Capture-Western, Reconstituted Complex	physical	11058129, 15009097, 22995475, (Europe PMC)	NA	BioGRID
KDM6B	Affinity Capture-Western	physical	20571128, (Europe PMC)	NA	BioGRID
KHDRBS1	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
KLF5	Affinity Capture-MS, Affinity Capture-Western, tandem affinity purification	physical, physical association	18729074, 19419955, (Europe PMC)	0.40	BioGRID, IntAct
KPNB1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
LAMA5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
LCK	Reconstituted Complex	physical	16806069, (Europe PMC)	NA	BioGRID
LDLRAD4	Affinity Capture-MS	physical	26186194, 28514442, (Europe PMC)	NA	BioGRID
LEF1	Affinity Capture-Western, Reconstituted Complex	physical	10890911, 15750622, (Europe PMC)	NA	BioGRID
LEMD3	Affinity Capture-MS, Two-hybrid, tandem affinity purification	physical, physical association	15489854, 18729074, (Europe PMC)	0.40	BioGRID, IntAct
MAPT	Affinity Capture-Western	physical	24964035, (Europe PMC)	NA	BioGRID
MECOM	Reconstituted Complex	physical	15849193, (Europe PMC)	NA	BioGRID
MED15	Affinity Capture-Western, coimmunoprecipitation	physical, physical association	12167862, (Europe PMC)	0.40	BioGRID, IntAct, MINT
MED24	Affinity Capture-Western, coimmunoprecipitation	physical, physical association	12167862, (Europe PMC)	0.40	BioGRID, IntAct, MINT
MED6	Affinity Capture-Western, coimmunoprecipitation	physical, physical association	12167862, (Europe PMC)	0.40	BioGRID, IntAct, MINT
MEF2A	Affinity Capture-Western, Reconstituted Complex	physical	11160896, (Europe PMC)	NA	BioGRID
MEF2C	Reconstituted Complex	physical	11160896, (Europe PMC)	NA	BioGRID
MYC	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	11804592, (Europe PMC)	NA	BioGRID
MYOCD	Reconstituted Complex	physical	16224064, (Europe PMC)	NA	BioGRID
NAGK	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
NCOA3	Affinity Capture-MS	physical	16751102, 18003620, (Europe PMC)	NA	BioGRID
NCOA6	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
NEDD4	Affinity Capture-Western	physical	15496141, (Europe PMC)	NA	BioGRID
NEDD4L	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	15231748, 19917253, 26555259, (Europe PMC)	0.37	BioGRID, IntAct, MINT
NEDD9	Affinity Capture-Western	physical	11118211, (Europe PMC)	NA	BioGRID
NEFM	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
NFIA	Reconstituted Complex	physical	18215124, (Europe PMC)	NA	BioGRID
NFYC	Affinity Capture-Western	physical	12023901, (Europe PMC)	NA	BioGRID
NOTCH4	Affinity Capture-Western	physical	16007227, (Europe PMC)	NA	BioGRID
NUP214	Affinity Capture-Western, Reconstituted Complex	physical	12917407, (Europe PMC)	NA	BioGRID
OPA1	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
OS9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
OTUB1	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex	physical	24071738, (Europe PMC)	NA	BioGRID
PAPOLA	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PAPPA	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PARD3	Reconstituted Complex	physical	12650946, (Europe PMC)	NA	BioGRID
PAXIP1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PCID2	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
PEX19	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PIAS3	Affinity Capture-Western, Reconstituted Complex	physical	14691252, (Europe PMC)	NA	BioGRID
PIAS4	Affinity Capture-Western, Two-hybrid	physical	12815042, 12904571, (Europe PMC)	NA	BioGRID
PIK3CA	Reconstituted Complex	physical	16806069, (Europe PMC)	NA	BioGRID
PIN1	Affinity Capture-Western, Reconstituted Complex	physical	19122240, 19920136, (Europe PMC)	NA	BioGRID
PLIN3	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PML	Affinity Capture-Western	physical	15356634, (Europe PMC)	NA	BioGRID
POU2AF1	Two-hybrid	physical	20211142, (Europe PMC)	NA	BioGRID
PPARG	Affinity Capture-Western	physical	23687300, (Europe PMC)	NA	BioGRID
PPP2R1A	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PRDM16	Affinity Capture-Western	physical	19049980, (Europe PMC)	NA	BioGRID
PRKAR1A	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSAP	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSG9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSMD11	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSMD8	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSPC1	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
PTMS	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
RANBP6	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RANBP9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RARB	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RGCC	Affinity Capture-Western	physical	21990365, (Europe PMC)	NA	BioGRID
RHOA	Reconstituted Complex, display technology, tandem affinity purification	physical, physical association	20195357, (Europe PMC)	0.52	BioGRID, IntAct
RIN1	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
RNF111	Affinity Capture-Western	physical	17591695, 18451154, 23530056, (Europe PMC)	NA	BioGRID
RNF123	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RNPC3	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ROCK1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RPS14	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RPS27A	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
RUNX1	Affinity Capture-Western	physical	10531362, (Europe PMC)	NA	BioGRID
RUNX2	Affinity Capture-Western	physical	10531362, (Europe PMC)	NA	BioGRID
RUNX3	Affinity Capture-Western	physical	10531362, (Europe PMC)	NA	BioGRID
RXRA	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
S100A4	Affinity Capture-Western	physical	20070253, (Europe PMC)	NA	BioGRID
SH2D2A	Affinity Capture-Western, Reconstituted Complex	physical	16806069, (Europe PMC)	NA	BioGRID
SIK3	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
SKI	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, cosedimentation through density gradient, proximity ligation assay, tandem affinity purification	association, physical, physical association	10485843, 10575014, 12732634, 12764135, 12874272, 14699069, 17283070, 18729074, 19032343, 20959473, 21149449, 22442258, 25670202, 26977879, 28468752, (Europe PMC)	0.83	BioGRID, IntAct
SKIL	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, proximity ligation assay, tandem affinity purification, two hybrid	physical, physical association	10531062, 11691834, 12426322, 12764135, 15231748, 16959829, 18729074, 22442258, 25059663, (Europe PMC)	0.37, 0.59	BioGRID, IntAct, MINT
SLC25A3	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
SLC25A5	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
SLC25A6	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
SMAD1	Affinity Capture-MS, Two-hybrid	physical	18729074, 9111321, (Europe PMC)	NA	BioGRID
SMAD2	Affinity Capture-Western, Two-hybrid, tandem affinity purification	physical, physical association	10085121, 12700238, 18729074, 9111321, (Europe PMC)	0.40	BioGRID, IntAct
SMAD3	Affinity Capture-MS, Affinity Capture-Western, Phenotypic Enhancement, Two-hybrid, tandem affinity purification, two hybrid	genetic, physical, physical association	12543979, 12700238, 18729074, 21988832, 26186194, 28514442, 9111321, 9311995, 9892009, (Europe PMC)	0.40, 0.57	BioGRID, IntAct
SMAD4	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure, Co-fractionation, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, proximity ligation assay, tandem affinity purification, two hybrid, x-ray crystallography	association, direct interaction, physical, physical association	10085121, 10199400, 10531362, 10781087, 10878024, 11027280, 11102446, 11114293, 11264182, 11274206, 11927552, 12167862, 12419246, 12543979, 12621041, 12732634, 12794086, 12808092, 15231748, 15350224, 15467747, 15761153, 15817471, 15922743, 16751102, 16916642, 17283070, 17591701, 18511908, 18729074, 18783722, 19135894, 19139564, 19917253, 21297662, 21454478, 21532621, 21988832, 22442258, 23788427, 24157709, 24584437, 25514493, 25609649, 26555259, 28468752, 9111321, 9288972, 9311995, 9389648, 9892009, (Europe PMC)	0.96	BioGRID, IntAct, MINT
SMAD5	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
SMAD6	Affinity Capture-Western	physical	9256479, (Europe PMC)	NA	BioGRID
SMAD7	Affinity Capture-Western, Phenotypic Suppression, Reconstituted Complex	genetic, physical	17438144, 26555259, 9892009, (Europe PMC)	NA	BioGRID
SMAD9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SMARCA4	Affinity Capture-MS, Affinity Capture-Western	physical	16751102, 18003620, (Europe PMC)	NA	BioGRID
SMARCC1	Affinity Capture-MS, display technology	physical, physical association	16751102, 18003620, 20195357, (Europe PMC)	0.40	BioGRID, IntAct
SMARCC2	Affinity Capture-MS	physical	16751102, 18003620, (Europe PMC)	NA	BioGRID
SMURF1	Affinity Capture-Western, Two-hybrid, two hybrid	physical, physical association	15221015, 15231748, 20207742, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SMURF2	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, isothermal titration calorimetry, nuclear magnetic resonance, peptide array, tandem affinity purification, two hybrid	direct interaction, physical, physical association	11016919, 11158580, 11389444, 15221015, 15231748, 18729074, 19122240, 19620243, 20937913, 22045334, 28468752, 28881580, (Europe PMC)	0.81	BioGRID, IntAct, MINT
SNAPIN	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SNIP1	Two-hybrid	physical	10887155, (Europe PMC)	NA	BioGRID
SNRNP70	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SNW1	Affinity Capture-MS, Phenotypic Enhancement, Reconstituted Complex, Two-hybrid, pull down, tandem affinity purification, two hybrid	genetic, physical, physical association	11278756, 18729074, (Europe PMC)	0.65	BioGRID, IntAct
SOD1	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
SOX9	Affinity Capture-Western	physical	15623506, (Europe PMC)	NA	BioGRID
SP1	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	10878024, 11114293, 22227581, (Europe PMC)	NA	BioGRID
SPTBN1	Affinity Capture-Western	physical	12543979, (Europe PMC)	NA	BioGRID
SQOR	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
SRI	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ST13	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ST5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
STRAP	Affinity Capture-Western, Phenotypic Suppression	genetic, physical	10757800, (Europe PMC)	NA	BioGRID
STUB1	Reconstituted Complex	physical	14701756, (Europe PMC)	NA	BioGRID
SYT1	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
TBC1D1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
TCF12	Affinity Capture-Western	physical	21828274, (Europe PMC)	NA	BioGRID
TGFBR1	Affinity Capture-Western, Biochemical Activity, Co-fractionation, anti tag coimmunoprecipitation	physical, physical association	11102446, 12543979, 15350225, 18511908, 19139564, 23687300, 25872870, (Europe PMC)	0.40	BioGRID, IntAct, MINT
TGIF1	Affinity Capture-Western, Two-hybrid	physical	10199400, 11371641, (Europe PMC)	NA	BioGRID
TGM2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
TP53	Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, proximity ligation assay	physical, physical association	12732139, 19345189, 19580641, 23687300, 25241761, 25670079, (Europe PMC)	0.70	BioGRID, IntAct
TRIM33	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association, physical, physical association	16751102, 18003620, 19135894, 20603019, 22196728, 23788427, (Europe PMC)	0.66	BioGRID, IntAct
TRIM62	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
TSC2	Affinity Capture-Western	physical	15066998, (Europe PMC)	NA	BioGRID
TUBA1B	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
U2AF2	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
UBA52	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
UBR5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
UCHL5	Reconstituted Complex	physical	16027725, (Europe PMC)	NA	BioGRID
USP15	Affinity Capture-Western	physical	21947082, 22344298, 26455393, (Europe PMC)	NA	BioGRID
USP9X	Affinity Capture-Western	physical	19135894, (Europe PMC)	NA	BioGRID
WASHC4	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
WRNIP1	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
WWP1	Affinity Capture-Western	physical	15221015, 15359284, (Europe PMC)	NA	BioGRID
WWP2	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	physical, physical association	18729074, 21258410, (Europe PMC)	0.66	BioGRID, IntAct
YAP1	Affinity Capture-Western	physical	27292796, (Europe PMC)	NA	BioGRID
YY1	Affinity Capture-MS, Reconstituted Complex, tandem affinity purification	physical, physical association	12808092, 18729074, (Europe PMC)	0.40	BioGRID, IntAct
ZEB1	Affinity Capture-Western	physical	12743038, (Europe PMC)	NA	BioGRID
ZEB2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ZFYVE9	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, tandem affinity purification, two hybrid	physical, physical association	11094085, 15231748, 15356634, 16916642, 18511908, 18729074, 23687300, 9865696, (Europe PMC)	0.40, 0.57	BioGRID, IntAct, MINT
ZMYND11	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
ZNF41	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ZNHIT6	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT

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Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
AFDN	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
AKAP8L	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
AKT1	Affinity Capture-Western, two hybrid array	physical, physical association	16362038, 24412244, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ANAPC2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ANK3	display technology, two hybrid	physical association	15231748, 20195357, (Europe PMC)	0.57	IntAct, MINT
ANP32B	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
ANP32E	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
ANTXR2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ATP1A1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ATP1B1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ATP5I	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ATP6V1D	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
BAZ1A	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
BEX3	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
BTBD2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
BUB3	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
CAD	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
CAMK2A	Co-localization, proximity ligation assay	physical, physical association	25241761, (Europe PMC)	0.40	BioGRID, IntAct
CCDC25	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
CCT6A	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
CHGB	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
CHUK	Affinity Capture-Western, anti tag coimmunoprecipitation, pull down	physical, physical association	18268325, (Europe PMC)	0.52	BioGRID, IntAct
CISH	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CLTA	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
COPS5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CORO2A	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
CPSF7	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
CREBBP	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	15231748, 15750622, 16751102, 17283070, 18003620, 20403362, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CSNK1D	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, tandem affinity purification	physical, physical association	18729074, 19139564, (Europe PMC)	0.40	BioGRID, IntAct
CTDSP1	anti tag coimmunoprecipitation	physical association	16882717, (Europe PMC)	0.40	IntAct
CTDSPL	anti tag coimmunoprecipitation	physical association	16882717, (Europe PMC)	0.40	IntAct
CUL5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CYLC2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
CYP11A1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DAB2	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down	physical, physical association	11387212, (Europe PMC)	0.52	BioGRID, IntAct
DCAF7	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
DCUN1D1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DDX1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
DGKA	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
DHX8	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
DLX4	pull down	direct interaction	21297662, (Europe PMC)	0.44	IntAct
DNAJA2	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
DNAJB5	two hybrid fragment pooling approach	physical association	23414517, (Europe PMC)	0.37	IntAct
DNAJC7	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DOCK8	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DOCK9	anti tag coimmunoprecipitation, tandem affinity purification	association, physical association	18729074, (Europe PMC)	0.40, 0.58	IntAct
DPP10	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
DRAP1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
DYNC1I1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
EEF1A1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
EIF3D	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
EIF3L	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
EIF4A2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
EIF5B	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ENSG00000138764	chromatin immunoprecipitation assay	association	21532621, (Europe PMC)	0.35	IntAct
EP300	Affinity Capture-Western, Two-hybrid, two hybrid	physical, physical association	10199400, 11371641, 12237408, 15623506, 21988832, (Europe PMC)	0.37	BioGRID, IntAct
EPB41L5	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
EPHB6	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ERBIN	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
ERC1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ERCC3	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ESF1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
FAM161B	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
FAM83G	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
FBP2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
FOS	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
FOXH1	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, affinity technology, two hybrid array, two hybrid prey pooling approach	physical, physical association	10199400, 10938097, 12732634, 15750622, 16916642, 21828274, 9288972, 9389648, 9702198, 9858566, (Europe PMC)	0.63	BioGRID, IntAct
GATAD2B	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
GFAP	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
GFER	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
GFM2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
GLI2	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association	25670079, (Europe PMC)	0.46	IntAct
GNAS	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
HDAC2	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
HECTD3	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
HMGN3	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
HNRNPA3	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
HSD17B3	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
HSPD1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
IFT57	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
IL1RAP	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ITGB4	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
JUN	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, display technology	association, physical, physical association	11371641, 20195357, 25609649, (Europe PMC)	0.56	BioGRID, IntAct, MINT
KHDRBS1	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
KIAA1109	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
KIF5B	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
KLF5	Affinity Capture-MS, Affinity Capture-Western, tandem affinity purification	physical, physical association	18729074, 19419955, (Europe PMC)	0.40	BioGRID, IntAct
KPNB1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
LAMA5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
LEMD3	Affinity Capture-MS, Two-hybrid, tandem affinity purification	physical, physical association	15489854, 18729074, (Europe PMC)	0.40	BioGRID, IntAct
LRPAP1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
MAP2K1	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
MCF2L	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
MED15	Affinity Capture-Western, coimmunoprecipitation	physical, physical association	12167862, (Europe PMC)	0.40	BioGRID, IntAct, MINT
MED24	Affinity Capture-Western, coimmunoprecipitation	physical, physical association	12167862, (Europe PMC)	0.40	BioGRID, IntAct, MINT
MED6	Affinity Capture-Western, coimmunoprecipitation	physical, physical association	12167862, (Europe PMC)	0.40	BioGRID, IntAct, MINT
MFN2	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
MKS1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
MTCH1	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
MTMR4	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	physical association	20061380, (Europe PMC)	0.52	IntAct, MINT
MYO18A	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
MYO5A	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
NAGK	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
NAP1L1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
NCOA6	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
NEDD4L	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	15231748, 19917253, 26555259, (Europe PMC)	0.37	BioGRID, IntAct, MINT
NEFM	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
OLIG1	anti tag coimmunoprecipitation	physical association	18923419, (Europe PMC)	0.40	IntAct, MINT
OPA1	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
OS9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PAPOLA	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PAPPA	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PAXIP1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PBDC1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
PCID2	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
PEX19	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PLIN3	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
POLR3D	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
PPAN	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
PPM1A	anti tag coimmunoprecipitation, pull down	direct interaction, physical association	16751101, (Europe PMC)	0.54	IntAct, MINT
PPP1R9B	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
PPP2R1A	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PREX2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
PRKAR1A	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PRMT5	cosedimentation through density gradient	association	19032343, (Europe PMC)	0.35	IntAct
PSAP	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSG9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSMD11	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSMD8	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSPC1	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
PTMS	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
RAN	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
RANBP3	pull down	physical association	21960005, (Europe PMC)	0.40	IntAct, MINT
RANBP6	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RANBP9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RARB	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RASA1	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
RHOA	Reconstituted Complex, display technology, tandem affinity purification	physical, physical association	20195357, (Europe PMC)	0.52	BioGRID, IntAct
RIMS1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
RIN1	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
RNF123	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RNPC3	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ROCK1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RPL30	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
RPL9	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
RPS14	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RPS3A	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
RSF1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
RXRA	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
S100A1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SARG	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
SEMA6A	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SENP2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SF3B2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SIK3	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
SKI	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, cosedimentation through density gradient, proximity ligation assay, tandem affinity purification	association, physical, physical association	10485843, 10575014, 12732634, 12764135, 12874272, 14699069, 17283070, 18729074, 19032343, 20959473, 21149449, 22442258, 25670202, 26977879, 28468752, (Europe PMC)	0.83	BioGRID, IntAct
SKIL	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, proximity ligation assay, tandem affinity purification, two hybrid	physical, physical association	10531062, 11691834, 12426322, 12764135, 15231748, 16959829, 18729074, 22442258, 25059663, (Europe PMC)	0.37, 0.59	BioGRID, IntAct, MINT
SLC25A3	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
SLC25A5	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
SLC25A6	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
SMAD2	Affinity Capture-Western, Two-hybrid, tandem affinity purification	physical, physical association	10085121, 12700238, 18729074, 9111321, (Europe PMC)	0.40	BioGRID, IntAct
SMAD3	Affinity Capture-MS, Affinity Capture-Western, Phenotypic Enhancement, Two-hybrid, tandem affinity purification, two hybrid	genetic, physical, physical association	12543979, 12700238, 18729074, 21988832, 26186194, 28514442, 9111321, 9311995, 9892009, (Europe PMC)	0.40, 0.57	BioGRID, IntAct
SMAD4	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure, Co-fractionation, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, proximity ligation assay, tandem affinity purification, two hybrid, x-ray crystallography	association, direct interaction, physical, physical association	10085121, 10199400, 10531362, 10781087, 10878024, 11027280, 11102446, 11114293, 11264182, 11274206, 11927552, 12167862, 12419246, 12543979, 12621041, 12732634, 12794086, 12808092, 15231748, 15350224, 15467747, 15761153, 15817471, 15922743, 16751102, 16916642, 17283070, 17591701, 18511908, 18729074, 18783722, 19135894, 19139564, 19917253, 21297662, 21454478, 21532621, 21988832, 22442258, 23788427, 24157709, 24584437, 25514493, 25609649, 26555259, 28468752, 9111321, 9288972, 9311995, 9389648, 9892009, (Europe PMC)	0.96	BioGRID, IntAct, MINT
SMAD9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SMARCC1	Affinity Capture-MS, display technology	physical, physical association	16751102, 18003620, 20195357, (Europe PMC)	0.40	BioGRID, IntAct
SMURF1	Affinity Capture-Western, Two-hybrid, two hybrid	physical, physical association	15221015, 15231748, 20207742, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SMURF2	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, isothermal titration calorimetry, nuclear magnetic resonance, peptide array, tandem affinity purification, two hybrid	direct interaction, physical, physical association	11016919, 11158580, 11389444, 15221015, 15231748, 18729074, 19122240, 19620243, 20937913, 22045334, 28468752, 28881580, (Europe PMC)	0.81	BioGRID, IntAct, MINT
SNAPIN	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SNRNP200	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SNRNP70	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SNW1	Affinity Capture-MS, Phenotypic Enhancement, Reconstituted Complex, Two-hybrid, pull down, tandem affinity purification, two hybrid	genetic, physical, physical association	11278756, 18729074, (Europe PMC)	0.65	BioGRID, IntAct
SOD1	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
SORBS1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SPART	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SQOR	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
SRI	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SRSF11	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SRSF5	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ST13	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ST5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SUPT6H	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SURF6	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SYT1	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
TAF3	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TBC1D1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
TCEAL6	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TERF1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TFCP2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TGFBR1	Affinity Capture-Western, Biochemical Activity, Co-fractionation, anti tag coimmunoprecipitation	physical, physical association	11102446, 12543979, 15350225, 18511908, 19139564, 23687300, 25872870, (Europe PMC)	0.40	BioGRID, IntAct, MINT
TGM2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
TNRC6B	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TOP1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TP53	Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, proximity ligation assay	physical, physical association	12732139, 19345189, 19580641, 23687300, 25241761, 25670079, (Europe PMC)	0.70	BioGRID, IntAct
TP63	anti bait coimmunoprecipitation	physical association	19345189, 21741598, (Europe PMC)	0.59	IntAct
TPR	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TPT1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TRIM33	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association, physical, physical association	16751102, 18003620, 19135894, 20603019, 22196728, 23788427, (Europe PMC)	0.66	BioGRID, IntAct
TRIM62	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
TRMO	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
TSPYL2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TUBA1B	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
TUBA4A	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
U2AF2	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
UBA52	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
UBC	anti tag coimmunoprecipitation	physical association	22045334, (Europe PMC)	0.40	IntAct, MINT
UBR5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
WASHC4	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
WRNIP1	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
WWP2	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	physical, physical association	18729074, 21258410, (Europe PMC)	0.66	BioGRID, IntAct
XPA	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
YY1	Affinity Capture-MS, Reconstituted Complex, tandem affinity purification	physical, physical association	12808092, 18729074, (Europe PMC)	0.40	BioGRID, IntAct
ZEB2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ZFR	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ZFYVE9	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, tandem affinity purification, two hybrid	physical, physical association	11094085, 15231748, 15356634, 16916642, 18511908, 18729074, 23687300, 9865696, (Europe PMC)	0.40, 0.57	BioGRID, IntAct, MINT
ZMYND11	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
ZNF106	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ZNF41	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ZNF510	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
ZNHIT6	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT

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Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
AFDN	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
AKT1	Affinity Capture-Western, two hybrid array	physical, physical association	16362038, 24412244, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ANAPC2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ANK3	display technology, two hybrid	physical association	15231748, 20195357, (Europe PMC)	0.57	IntAct, MINT
ANTXR2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
BAZ1A	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
BTBD2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CISH	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
COPS5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CORO2A	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
CREBBP	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	15231748, 15750622, 16751102, 17283070, 18003620, 20403362, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CUL5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CYLC2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
CYP11A1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DCUN1D1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DNAJC7	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DOCK8	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
EEF1A1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
EIF3L	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
FAM161B	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
FBP2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
GATAD2B	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
HSD17B3	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
JUN	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, display technology	association, physical, physical association	11371641, 20195357, 25609649, (Europe PMC)	0.56	BioGRID, IntAct, MINT
KHDRBS1	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
KPNB1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
LAMA5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
MAP2K1	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
MED15	Affinity Capture-Western, coimmunoprecipitation	physical, physical association	12167862, (Europe PMC)	0.40	BioGRID, IntAct, MINT
MED24	Affinity Capture-Western, coimmunoprecipitation	physical, physical association	12167862, (Europe PMC)	0.40	BioGRID, IntAct, MINT
MED6	Affinity Capture-Western, coimmunoprecipitation	physical, physical association	12167862, (Europe PMC)	0.40	BioGRID, IntAct, MINT
MTMR4	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	physical association	20061380, (Europe PMC)	0.52	IntAct, MINT
NAGK	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
NCOA6	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
NEDD4L	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	15231748, 19917253, 26555259, (Europe PMC)	0.37	BioGRID, IntAct, MINT
OLIG1	anti tag coimmunoprecipitation	physical association	18923419, (Europe PMC)	0.40	IntAct, MINT
OS9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PAPOLA	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PAPPA	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PAXIP1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PEX19	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PLIN3	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PPM1A	anti tag coimmunoprecipitation, pull down	direct interaction, physical association	16751101, (Europe PMC)	0.54	IntAct, MINT
PPP2R1A	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PRKAR1A	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSAP	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSG9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSMD11	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSMD8	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RANBP3	pull down	physical association	21960005, (Europe PMC)	0.40	IntAct, MINT
RANBP6	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RANBP9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RARB	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RASA1	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
RNF123	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RNPC3	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ROCK1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RPS14	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RXRA	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SKIL	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, proximity ligation assay, tandem affinity purification, two hybrid	physical, physical association	10531062, 11691834, 12426322, 12764135, 15231748, 16959829, 18729074, 22442258, 25059663, (Europe PMC)	0.37, 0.59	BioGRID, IntAct, MINT
SMAD4	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure, Co-fractionation, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, proximity ligation assay, tandem affinity purification, two hybrid, x-ray crystallography	association, direct interaction, physical, physical association	10085121, 10199400, 10531362, 10781087, 10878024, 11027280, 11102446, 11114293, 11264182, 11274206, 11927552, 12167862, 12419246, 12543979, 12621041, 12732634, 12794086, 12808092, 15231748, 15350224, 15467747, 15761153, 15817471, 15922743, 16751102, 16916642, 17283070, 17591701, 18511908, 18729074, 18783722, 19135894, 19139564, 19917253, 21297662, 21454478, 21532621, 21988832, 22442258, 23788427, 24157709, 24584437, 25514493, 25609649, 26555259, 28468752, 9111321, 9288972, 9311995, 9389648, 9892009, (Europe PMC)	0.96	BioGRID, IntAct, MINT
SMAD9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SMURF1	Affinity Capture-Western, Two-hybrid, two hybrid	physical, physical association	15221015, 15231748, 20207742, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SMURF2	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, isothermal titration calorimetry, nuclear magnetic resonance, peptide array, tandem affinity purification, two hybrid	direct interaction, physical, physical association	11016919, 11158580, 11389444, 15221015, 15231748, 18729074, 19122240, 19620243, 20937913, 22045334, 28468752, 28881580, (Europe PMC)	0.81	BioGRID, IntAct, MINT
SNAPIN	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SNRNP70	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SRI	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ST13	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ST5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
TBC1D1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
TGFBR1	Affinity Capture-Western, Biochemical Activity, Co-fractionation, anti tag coimmunoprecipitation	physical, physical association	11102446, 12543979, 15350225, 18511908, 19139564, 23687300, 25872870, (Europe PMC)	0.40	BioGRID, IntAct, MINT
TGM2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
TRIM62	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
TRMO	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
UBA52	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
UBC	anti tag coimmunoprecipitation	physical association	22045334, (Europe PMC)	0.40	IntAct, MINT
UBR5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
WASHC4	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
XPA	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
ZEB2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ZFYVE9	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, tandem affinity purification, two hybrid	physical, physical association	11094085, 15231748, 15356634, 16916642, 18511908, 18729074, 23687300, 9865696, (Europe PMC)	0.40, 0.57	BioGRID, IntAct, MINT
ZMYND11	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
ZNF41	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ZNF510	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
ZNHIT6	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT

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Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
ABTB1	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
ACVR1B	Affinity Capture-Western	physical	9892009, (Europe PMC)	NA	BioGRID
ACVR2B	Affinity Capture-Western	physical	11094085, (Europe PMC)	NA	BioGRID
AFDN	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
AFDN	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
AKAP8L	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
AKT1	Affinity Capture-Western, two hybrid array	physical, physical association	16362038, 24412244, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ANAPC10	Affinity Capture-Western, Reconstituted Complex	physical	15144564, (Europe PMC)	NA	BioGRID
ANAPC2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ANK3	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
ANK3	display technology, two hybrid	physical association	15231748, 20195357, (Europe PMC)	0.57	IntAct, MINT
ANP32B	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
ANP32E	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
ANTXR2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ARID1A	Affinity Capture-MS	physical	18003620, (Europe PMC)	NA	BioGRID
ARID1B	Affinity Capture-MS	physical	16751102, (Europe PMC)	NA	BioGRID
ATAD3B	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
ATF3	Affinity Capture-Western	physical	20930144, (Europe PMC)	NA	BioGRID
ATP1A1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ATP1B1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ATP5I	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ATP5ME	Reconstituted Complex	physical	20195357, (Europe PMC)	NA	BioGRID
ATP6V1D	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
BAZ1A	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
BEX3	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
BPTF	Reconstituted Complex	physical	18974875, (Europe PMC)	NA	BioGRID
BRCA2	Affinity Capture-Western	physical	12165866, (Europe PMC)	NA	BioGRID
BTBD2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
BUB3	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
C1orf116	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
C22orf46	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
CAD	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
CAD	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
CAMK2A	Co-localization, proximity ligation assay	physical, physical association	25241761, (Europe PMC)	0.40	BioGRID, IntAct
CAMK2G	Biochemical Activity	physical	11027280, (Europe PMC)	NA	BioGRID
CAV1	Co-fractionation	physical	11102446, (Europe PMC)	NA	BioGRID
CCDC25	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
CCT6A	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
CDC16	Affinity Capture-Western	physical	11691834, (Europe PMC)	NA	BioGRID
CDC27	Affinity Capture-Western	physical	11691834, (Europe PMC)	NA	BioGRID
CDK2	Biochemical Activity	physical	15241418, (Europe PMC)	NA	BioGRID
CDK4	Biochemical Activity	physical	15241418, (Europe PMC)	NA	BioGRID
CDK8	Biochemical Activity	physical	19914168, (Europe PMC)	NA	BioGRID
CDK9	Biochemical Activity	physical	19914168, (Europe PMC)	NA	BioGRID
CHGB	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
CHUK	Affinity Capture-Western, anti tag coimmunoprecipitation, pull down	physical, physical association	18268325, (Europe PMC)	0.52	BioGRID, IntAct
CISH	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CITED2	Affinity Capture-Western	physical	16619037, (Europe PMC)	NA	BioGRID
CLTA	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
COPS5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CORO2A	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
CPSF7	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
CREBBP	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	15231748, 15750622, 16751102, 17283070, 18003620, 20403362, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CSH1	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
CSH2	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
CSNK1D	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, tandem affinity purification	physical, physical association	18729074, 19139564, (Europe PMC)	0.40	BioGRID, IntAct
CTDSP1	anti tag coimmunoprecipitation	physical association	16882717, (Europe PMC)	0.40	IntAct
CTDSPL	anti tag coimmunoprecipitation	physical association	16882717, (Europe PMC)	0.40	IntAct
CTNNB1	Affinity Capture-Western	physical	12000714, 20571128, (Europe PMC)	NA	BioGRID
CUL5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CYLC2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
CYP11A1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DAB2	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, pull down	physical, physical association	11387212, (Europe PMC)	0.52	BioGRID, IntAct
DCAF7	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
DCUN1D1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DDX1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
DDX3Y	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
DGKA	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
DHX8	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
DLX4	pull down	direct interaction	21297662, (Europe PMC)	0.44	IntAct
DNAJA2	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
DNAJB5	two hybrid fragment pooling approach	physical association	23414517, (Europe PMC)	0.37	IntAct
DNAJC7	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DOCK8	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DOCK9	Affinity Capture-MS, Affinity Capture-Western	physical	18729074, (Europe PMC)	NA	BioGRID
DOCK9	anti tag coimmunoprecipitation, tandem affinity purification	association, physical association	18729074, (Europe PMC)	0.40, 0.58	IntAct
DPP10	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
DRAP1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
DVL1	Reconstituted Complex	physical	12650946, (Europe PMC)	NA	BioGRID
DYNC1H1	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
DYNC1I1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
EEF1A1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
EID2	Affinity Capture-Western	physical	14612439, (Europe PMC)	NA	BioGRID
EIF3D	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
EIF3L	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
EIF3L	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
EIF4A2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
EIF5B	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ELAC2	Affinity Capture-Western, Reconstituted Complex	physical	16636667, (Europe PMC)	NA	BioGRID
ELAVL1	Affinity Capture-RNA	physical	19322201, (Europe PMC)	NA	BioGRID
ENSG00000138764	chromatin immunoprecipitation assay	association	21532621, (Europe PMC)	0.35	IntAct
EP300	Affinity Capture-Western, Two-hybrid, two hybrid	physical, physical association	10199400, 11371641, 12237408, 15623506, 21988832, (Europe PMC)	0.37	BioGRID, IntAct
EPB41L5	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
EPHB6	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ERBIN	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex	physical	12650946, 17591701, 18003620, 18729074, (Europe PMC)	NA	BioGRID
ERBIN	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
ERC1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ERCC3	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ESF1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ESR1	Affinity Capture-Western, Reconstituted Complex	physical	11555647, 20207742, (Europe PMC)	NA	BioGRID
ETV4	Affinity Capture-Western, Two-hybrid	physical	21613609, (Europe PMC)	NA	BioGRID
FAM161B	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
FAM83G	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
FBP2	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
FHL1	Affinity Capture-Western, Reconstituted Complex	physical	19139564, (Europe PMC)	NA	BioGRID
FHL2	Affinity Capture-Western, Reconstituted Complex	physical	19139564, (Europe PMC)	NA	BioGRID
FHL3	Affinity Capture-Western, Reconstituted Complex	physical	19139564, (Europe PMC)	NA	BioGRID
FOS	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
FOXH1	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, affinity technology, two hybrid array, two hybrid prey pooling approach	physical, physical association	10199400, 10938097, 12732634, 15750622, 16916642, 21828274, 9288972, 9389648, 9702198, 9858566, (Europe PMC)	0.63	BioGRID, IntAct
GATAD2B	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
GFAP	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
GFER	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
GFM2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
GLI1	Affinity Capture-Western	physical	24739390, (Europe PMC)	NA	BioGRID
GLI2	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association	25670079, (Europe PMC)	0.46	IntAct
GNAS	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
GTF2I	Affinity Capture-Western	physical	16055724, (Europe PMC)	NA	BioGRID
GTF2IRD1	Affinity Capture-Western	physical	16055724, (Europe PMC)	NA	BioGRID
HDAC1	Affinity Capture-Western	physical	10199400, 11226163, 14699069, (Europe PMC)	NA	BioGRID
HDAC2	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
HECTD3	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
HGS	Affinity Capture-Western	physical	11094085, (Europe PMC)	NA	BioGRID
HIPK2	Reconstituted Complex	physical	12874272, (Europe PMC)	NA	BioGRID
HMGN3	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
HNRNPA3	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
HSD17B3	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
HSPA4	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
HSPD1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
IFT57	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
IL1RAP	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ING2	Affinity Capture-Western	physical	18334480, (Europe PMC)	NA	BioGRID
INSR	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	9092546, (Europe PMC)	NA	BioGRID
IRF3	Affinity Capture-Western	physical	14729983, (Europe PMC)	NA	BioGRID
IRF7	Affinity Capture-Western, Reconstituted Complex	physical	14729983, (Europe PMC)	NA	BioGRID
ITCH	Affinity Capture-Western, Biochemical Activity	physical	15350225, (Europe PMC)	NA	BioGRID
ITGB4	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
JUN	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, display technology	association, physical, physical association	11371641, 20195357, 25609649, (Europe PMC)	0.56	BioGRID, IntAct, MINT
KAT2A	Affinity Capture-Western	physical	15009097, (Europe PMC)	NA	BioGRID
KAT2B	Affinity Capture-Western, Reconstituted Complex	physical	11058129, 15009097, 22995475, (Europe PMC)	NA	BioGRID
KDM6B	Affinity Capture-Western	physical	20571128, (Europe PMC)	NA	BioGRID
KHDRBS1	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
KHDRBS1	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
KIAA1109	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
KIF5B	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
KLF5	Affinity Capture-MS, Affinity Capture-Western, tandem affinity purification	physical, physical association	18729074, 19419955, (Europe PMC)	0.40	BioGRID, IntAct
KPNB1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
LAMA5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
LCK	Reconstituted Complex	physical	16806069, (Europe PMC)	NA	BioGRID
LDLRAD4	Affinity Capture-MS	physical	26186194, 28514442, (Europe PMC)	NA	BioGRID
LEF1	Affinity Capture-Western, Reconstituted Complex	physical	10890911, 15750622, (Europe PMC)	NA	BioGRID
LEMD3	Affinity Capture-MS, Two-hybrid, tandem affinity purification	physical, physical association	15489854, 18729074, (Europe PMC)	0.40	BioGRID, IntAct
LRPAP1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
MAP2K1	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
MAPT	Affinity Capture-Western	physical	24964035, (Europe PMC)	NA	BioGRID
MCF2L	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
MECOM	Reconstituted Complex	physical	15849193, (Europe PMC)	NA	BioGRID
MED15	Affinity Capture-Western, coimmunoprecipitation	physical, physical association	12167862, (Europe PMC)	0.40	BioGRID, IntAct, MINT
MED24	Affinity Capture-Western, coimmunoprecipitation	physical, physical association	12167862, (Europe PMC)	0.40	BioGRID, IntAct, MINT
MED6	Affinity Capture-Western, coimmunoprecipitation	physical, physical association	12167862, (Europe PMC)	0.40	BioGRID, IntAct, MINT
MEF2A	Affinity Capture-Western, Reconstituted Complex	physical	11160896, (Europe PMC)	NA	BioGRID
MEF2C	Reconstituted Complex	physical	11160896, (Europe PMC)	NA	BioGRID
MFN2	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
MKS1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
MTCH1	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
MTMR4	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	physical association	20061380, (Europe PMC)	0.52	IntAct, MINT
MYC	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	11804592, (Europe PMC)	NA	BioGRID
MYO18A	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
MYO5A	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
MYOCD	Reconstituted Complex	physical	16224064, (Europe PMC)	NA	BioGRID
NAGK	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
NAP1L1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
NCOA3	Affinity Capture-MS	physical	16751102, 18003620, (Europe PMC)	NA	BioGRID
NCOA6	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
NEDD4	Affinity Capture-Western	physical	15496141, (Europe PMC)	NA	BioGRID
NEDD4L	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	15231748, 19917253, 26555259, (Europe PMC)	0.37	BioGRID, IntAct, MINT
NEDD9	Affinity Capture-Western	physical	11118211, (Europe PMC)	NA	BioGRID
NEFM	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
NFIA	Reconstituted Complex	physical	18215124, (Europe PMC)	NA	BioGRID
NFYC	Affinity Capture-Western	physical	12023901, (Europe PMC)	NA	BioGRID
NOTCH4	Affinity Capture-Western	physical	16007227, (Europe PMC)	NA	BioGRID
NUP214	Affinity Capture-Western, Reconstituted Complex	physical	12917407, (Europe PMC)	NA	BioGRID
OLIG1	anti tag coimmunoprecipitation	physical association	18923419, (Europe PMC)	0.40	IntAct, MINT
OPA1	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
OS9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
OTUB1	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex	physical	24071738, (Europe PMC)	NA	BioGRID
PAPOLA	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PAPPA	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PARD3	Reconstituted Complex	physical	12650946, (Europe PMC)	NA	BioGRID
PAXIP1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PBDC1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
PCID2	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
PEX19	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PIAS3	Affinity Capture-Western, Reconstituted Complex	physical	14691252, (Europe PMC)	NA	BioGRID
PIAS4	Affinity Capture-Western, Two-hybrid	physical	12815042, 12904571, (Europe PMC)	NA	BioGRID
PIK3CA	Reconstituted Complex	physical	16806069, (Europe PMC)	NA	BioGRID
PIN1	Affinity Capture-Western, Reconstituted Complex	physical	19122240, 19920136, (Europe PMC)	NA	BioGRID
PLIN3	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PML	Affinity Capture-Western	physical	15356634, (Europe PMC)	NA	BioGRID
POLR3D	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
POU2AF1	Two-hybrid	physical	20211142, (Europe PMC)	NA	BioGRID
PPAN	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
PPARG	Affinity Capture-Western	physical	23687300, (Europe PMC)	NA	BioGRID
PPM1A	anti tag coimmunoprecipitation, pull down	direct interaction, physical association	16751101, (Europe PMC)	0.54	IntAct, MINT
PPP1R9B	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
PPP2R1A	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PRDM16	Affinity Capture-Western	physical	19049980, (Europe PMC)	NA	BioGRID
PREX2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
PRKAR1A	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PRMT5	cosedimentation through density gradient	association	19032343, (Europe PMC)	0.35	IntAct
PSAP	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSG9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSMD11	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSMD8	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PSPC1	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
PTMS	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
RAN	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
RANBP3	pull down	physical association	21960005, (Europe PMC)	0.40	IntAct, MINT
RANBP6	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RANBP9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RARB	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RASA1	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
RGCC	Affinity Capture-Western	physical	21990365, (Europe PMC)	NA	BioGRID
RHOA	Reconstituted Complex, display technology, tandem affinity purification	physical, physical association	20195357, (Europe PMC)	0.52	BioGRID, IntAct
RIMS1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
RIN1	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
RNF111	Affinity Capture-Western	physical	17591695, 18451154, 23530056, (Europe PMC)	NA	BioGRID
RNF123	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RNPC3	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ROCK1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RPL30	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
RPL9	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
RPS14	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
RPS27A	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
RPS3A	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
RSF1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
RUNX1	Affinity Capture-Western	physical	10531362, (Europe PMC)	NA	BioGRID
RUNX2	Affinity Capture-Western	physical	10531362, (Europe PMC)	NA	BioGRID
RUNX3	Affinity Capture-Western	physical	10531362, (Europe PMC)	NA	BioGRID
RXRA	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
S100A1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
S100A4	Affinity Capture-Western	physical	20070253, (Europe PMC)	NA	BioGRID
SARG	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
SEMA6A	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SENP2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SF3B2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SH2D2A	Affinity Capture-Western, Reconstituted Complex	physical	16806069, (Europe PMC)	NA	BioGRID
SIK3	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
SIK3	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
SKI	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, cosedimentation through density gradient, proximity ligation assay, tandem affinity purification	association, physical, physical association	10485843, 10575014, 12732634, 12764135, 12874272, 14699069, 17283070, 18729074, 19032343, 20959473, 21149449, 22442258, 25670202, 26977879, 28468752, (Europe PMC)	0.83	BioGRID, IntAct
SKIL	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, proximity ligation assay, tandem affinity purification, two hybrid	physical, physical association	10531062, 11691834, 12426322, 12764135, 15231748, 16959829, 18729074, 22442258, 25059663, (Europe PMC)	0.37, 0.59	BioGRID, IntAct, MINT
SLC25A3	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
SLC25A5	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
SLC25A6	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
SMAD1	Affinity Capture-MS, Two-hybrid	physical	18729074, 9111321, (Europe PMC)	NA	BioGRID
SMAD2	Affinity Capture-Western, Two-hybrid, tandem affinity purification	physical, physical association	10085121, 12700238, 18729074, 9111321, (Europe PMC)	0.40	BioGRID, IntAct
SMAD3	Affinity Capture-MS, Affinity Capture-Western, Phenotypic Enhancement, Two-hybrid, tandem affinity purification, two hybrid	genetic, physical, physical association	12543979, 12700238, 18729074, 21988832, 26186194, 28514442, 9111321, 9311995, 9892009, (Europe PMC)	0.40, 0.57	BioGRID, IntAct
SMAD4	Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure, Co-fractionation, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, proximity ligation assay, tandem affinity purification, two hybrid, x-ray crystallography	association, direct interaction, physical, physical association	10085121, 10199400, 10531362, 10781087, 10878024, 11027280, 11102446, 11114293, 11264182, 11274206, 11927552, 12167862, 12419246, 12543979, 12621041, 12732634, 12794086, 12808092, 15231748, 15350224, 15467747, 15761153, 15817471, 15922743, 16751102, 16916642, 17283070, 17591701, 18511908, 18729074, 18783722, 19135894, 19139564, 19917253, 21297662, 21454478, 21532621, 21988832, 22442258, 23788427, 24157709, 24584437, 25514493, 25609649, 26555259, 28468752, 9111321, 9288972, 9311995, 9389648, 9892009, (Europe PMC)	0.96	BioGRID, IntAct, MINT
SMAD5	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
SMAD6	Affinity Capture-Western	physical	9256479, (Europe PMC)	NA	BioGRID
SMAD7	Affinity Capture-Western, Phenotypic Suppression, Reconstituted Complex	genetic, physical	17438144, 26555259, 9892009, (Europe PMC)	NA	BioGRID
SMAD9	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SMARCA4	Affinity Capture-MS, Affinity Capture-Western	physical	16751102, 18003620, (Europe PMC)	NA	BioGRID
SMARCC1	Affinity Capture-MS, display technology	physical, physical association	16751102, 18003620, 20195357, (Europe PMC)	0.40	BioGRID, IntAct
SMARCC2	Affinity Capture-MS	physical	16751102, 18003620, (Europe PMC)	NA	BioGRID
SMURF1	Affinity Capture-Western, Two-hybrid, two hybrid	physical, physical association	15221015, 15231748, 20207742, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SMURF2	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, isothermal titration calorimetry, nuclear magnetic resonance, peptide array, tandem affinity purification, two hybrid	direct interaction, physical, physical association	11016919, 11158580, 11389444, 15221015, 15231748, 18729074, 19122240, 19620243, 20937913, 22045334, 28468752, 28881580, (Europe PMC)	0.81	BioGRID, IntAct, MINT
SNAPIN	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SNIP1	Two-hybrid	physical	10887155, (Europe PMC)	NA	BioGRID
SNRNP200	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SNRNP70	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SNW1	Affinity Capture-MS, Phenotypic Enhancement, Reconstituted Complex, Two-hybrid, pull down, tandem affinity purification, two hybrid	genetic, physical, physical association	11278756, 18729074, (Europe PMC)	0.65	BioGRID, IntAct
SOD1	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
SORBS1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SOX9	Affinity Capture-Western	physical	15623506, (Europe PMC)	NA	BioGRID
SP1	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	10878024, 11114293, 22227581, (Europe PMC)	NA	BioGRID
SPART	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SPTBN1	Affinity Capture-Western	physical	12543979, (Europe PMC)	NA	BioGRID
SQOR	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
SQOR	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
SRI	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SRSF11	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SRSF5	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ST13	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ST5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
STRAP	Affinity Capture-Western, Phenotypic Suppression	genetic, physical	10757800, (Europe PMC)	NA	BioGRID
STUB1	Reconstituted Complex	physical	14701756, (Europe PMC)	NA	BioGRID
SUPT6H	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SURF6	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SYT1	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
TAF3	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TBC1D1	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
TCEAL6	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TCF12	Affinity Capture-Western	physical	21828274, (Europe PMC)	NA	BioGRID
TERF1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TFCP2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TGFBR1	Affinity Capture-Western, Biochemical Activity, Co-fractionation, anti tag coimmunoprecipitation	physical, physical association	11102446, 12543979, 15350225, 18511908, 19139564, 23687300, 25872870, (Europe PMC)	0.40	BioGRID, IntAct, MINT
TGIF1	Affinity Capture-Western, Two-hybrid	physical	10199400, 11371641, (Europe PMC)	NA	BioGRID
TGM2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
TNRC6B	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TOP1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TP53	Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, proximity ligation assay	physical, physical association	12732139, 19345189, 19580641, 23687300, 25241761, 25670079, (Europe PMC)	0.70	BioGRID, IntAct
TP63	anti bait coimmunoprecipitation	physical association	19345189, 21741598, (Europe PMC)	0.59	IntAct
TPR	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TPT1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TRIM33	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association, physical, physical association	16751102, 18003620, 19135894, 20603019, 22196728, 23788427, (Europe PMC)	0.66	BioGRID, IntAct
TRIM62	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
TRMO	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
TSC2	Affinity Capture-Western	physical	15066998, (Europe PMC)	NA	BioGRID
TSPYL2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
TUBA1B	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
TUBA4A	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
U2AF2	Affinity Capture-MS, tandem affinity purification	physical, physical association	18729074, (Europe PMC)	0.40	BioGRID, IntAct
UBA52	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
UBC	anti tag coimmunoprecipitation	physical association	22045334, (Europe PMC)	0.40	IntAct, MINT
UBR5	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
UCHL5	Reconstituted Complex	physical	16027725, (Europe PMC)	NA	BioGRID
USP15	Affinity Capture-Western	physical	21947082, 22344298, 26455393, (Europe PMC)	NA	BioGRID
USP9X	Affinity Capture-Western	physical	19135894, (Europe PMC)	NA	BioGRID
WASHC4	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
WASHC4	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
WRNIP1	Affinity Capture-MS	physical	18729074, (Europe PMC)	NA	BioGRID
WRNIP1	tandem affinity purification	physical association	18729074, (Europe PMC)	0.40	IntAct
WWP1	Affinity Capture-Western	physical	15221015, 15359284, (Europe PMC)	NA	BioGRID
WWP2	Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	physical, physical association	18729074, 21258410, (Europe PMC)	0.66	BioGRID, IntAct
XPA	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
YAP1	Affinity Capture-Western	physical	27292796, (Europe PMC)	NA	BioGRID
YY1	Affinity Capture-MS, Reconstituted Complex, tandem affinity purification	physical, physical association	12808092, 18729074, (Europe PMC)	0.40	BioGRID, IntAct
ZEB1	Affinity Capture-Western	physical	12743038, (Europe PMC)	NA	BioGRID
ZEB2	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ZFR	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ZFYVE9	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, tandem affinity purification, two hybrid	physical, physical association	11094085, 15231748, 15356634, 16916642, 18511908, 18729074, 23687300, 9865696, (Europe PMC)	0.40, 0.57	BioGRID, IntAct, MINT
ZMYND11	Two-hybrid	physical	15231748, (Europe PMC)	NA	BioGRID
ZMYND11	two hybrid	physical association	15231748, (Europe PMC)	0.37	IntAct, MINT
ZNF106	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
ZNF41	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT
ZNF510	two hybrid array	physical association	24412244, (Europe PMC)	0.37	IntAct, MINT
ZNHIT6	Two-hybrid, two hybrid	physical, physical association	15231748, (Europe PMC)	0.37	BioGRID, IntAct, MINT

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SMAD2