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REACTOME Pathway - Downregulation of TGF-beta receptor signaling Name UniProt AC Dephosphorylates following protein substrates: Dephosphorylates following non-protein substrates: PPP1CC P36873 FXYD1 , AURKA , AXIN1 , AHCYL1 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , CASP2 , TNNT2 , CSNK1E , HIST1H3A , CENPE , GAD2 , PTK2 , PRKCD , STK4 , STK3 , ATM , IKZF1 , CAMK2G , POLD3 , PRKD1 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , POLR2A , TTK , RYR2 , Non-protein substrates of this phosphatase are not reported yet PPP1CA P62136 AURKA , AXIN1 , AHCYL1 , TBC1D4 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , PRKCB , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , EIF2AK2 , LMNB1 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , BRCA1 , CASP2 , TNNT2 , CSNK1E , CDK9 , CASP9 , PPP1CA , GAD2 , PTK2 , PRKCD , STK4 , STK3 , IKZF1 , CAMK2G , POLD3 , PRKD1 , PARD3 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , SF3B1 , POLR2A , RYR2 , SRSF1 , SLC6A3 , SENP3 , Non-protein substrates of this phosphatase are not reported yet PPP1CB P62140 AURKA , AXIN1 , AHCYL1 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , CASP2 , TNNT2 , CSNK1E , GAD2 , PTK2 , PRKCD , STK4 , STK3 , IKZF1 , CAMK2G , POLD3 , PRKD1 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , POLR2A , RYR2 , CDC5L , Non-protein substrates of this phosphatase are not reported yet MTMR4 Q9NYA4 SMAD3 , 1-phosphatidyl-1D-myo-inositol 3-phosphate ,
Name UniProt AC Dephosphorylated by: TGFBR1 P36897 PPP1CC , PPP1CA , PPP1CB , PPP1CA P62136 PPP1CA , SMAD3 P84022 MTMR4 , PPP2CA , PPP2CB , PPM1A , CTDSP1 , CTDSP2 , CTDSPL , SMAD2 Q15796 PPM1A , CTDSP1 , CTDSP2 , CTDSPL ,