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KEGG Pathway - Proteoglycans in cancer - Homo sapiens (human) Name UniProt AC Dephosphorylates following protein substrates: Dephosphorylates following non-protein substrates: PTPN6 P29350 JAK2 , CTNND1 , NFAT5 , EGFR , ESR1 , NTRK1 , LCK , LYN , ROS1 , KIT , ACTN1 , SRC , CD33 , CD22 , NOS1 , HOXA10 , KDR , CASP8 , GAB2 , ERBB2 , ERBB4 , Non-protein substrates of this phosphatase are not reported yet PPP1CC P36873 FXYD1 , AURKA , AXIN1 , AHCYL1 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , CASP2 , TNNT2 , CSNK1E , HIST1H3A , CENPE , GAD2 , PTK2 , PRKCD , STK4 , STK3 , ATM , IKZF1 , CAMK2G , POLD3 , PRKD1 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , POLR2A , TTK , RYR2 , Non-protein substrates of this phosphatase are not reported yet PPP1CA P62136 AURKA , AXIN1 , AHCYL1 , TBC1D4 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , PRKCB , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , EIF2AK2 , LMNB1 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , BRCA1 , CASP2 , TNNT2 , CSNK1E , CDK9 , CASP9 , PPP1CA , GAD2 , PTK2 , PRKCD , STK4 , STK3 , IKZF1 , CAMK2G , POLD3 , PRKD1 , PARD3 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , SF3B1 , POLR2A , RYR2 , SRSF1 , SLC6A3 , SENP3 , Non-protein substrates of this phosphatase are not reported yet PPP1CB P62140 AURKA , AXIN1 , AHCYL1 , NCOR1 , SRSF10 , MBP , RAF1 , TP53 , EIF2S1 , RB1 , MAPT , H2AFX , PRKCA , TNNI3 , RYR1 , CAD , NOS3 , CDC25C , AKT1 , PTPN7 , IRS1 , TGFBR1 , CASP2 , TNNT2 , CSNK1E , GAD2 , PTK2 , PRKCD , STK4 , STK3 , IKZF1 , CAMK2G , POLD3 , PRKD1 , BAD , MASTL , GAD1 , SMO , CEP250 , CAMK2A , SF3B1 , POLR2A , RYR2 , CDC5L , Non-protein substrates of this phosphatase are not reported yet PTPN11 Q06124 SPRY2 , SPRY1 , JAK2 , MPZL1 , EGFR , PDGFRB , SRC , SELE , IRS1 , KDR , STAT1 , STAT5A , PXN , STAT5B , SIRPA , ARHGAP5 , GAB1 , PTK2B , PAG1 , GAB2 , MAP3K4 , ERBB2 , LCK , CD28 , ERBB2 , PDCD1 , ERBB4 , Non-protein substrates of this phosphatase are not reported yet
Name UniProt AC Dephosphorylated by: EGFR P00533 CDC25A , ACP1 , PTPN1 , PTPN9 , PTPRU , PTPRJ , PTPRK , PTPRS , PTPN6 , PTPN11 , PTPN2 , DUSP3 , UBASH3B , PTPRA , PTPRB , PTPN12 , PTPRH , MYC P01106 PPP2CA , PPP2CB , CTDSP1 , ESR1 P03372 DUSP22 , PTPN1 , PTPN6 , RAF1 P04049 CDC25A , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPP5C , PTPN1 , ERBB2 P04626 ACPP , PTPN9 , DUSP3 , PTPN6 , PTPN12 , PTPN11 , PTPN18 , PTPN11 , TP53 P04637 CDC14A , CDC14B , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PPM1D , DUSP26 , ITGB1 P05556 PPP2CA , PPP2CB , PTP4A3 , PRKCB P05771 PHLPP1 , PHLPP2 , PPP1CA , PPP2CA , PPP2CB , IGF1R P08069 PTPN1 , MET P08581 PTPRF , PTPN1 , PTPRB , PTPRJ , PTPN2 , SRC P12931 PTPN23 , ACP1 , PPP2CA , PPP2CB , PTPN1 , PTPN21 , PTPN12 , PTPRA , PTPRE , PTPRJ , PTPRH , PTPN6 , PTPN11 , PTPN2 , EZR P15311 PTP4A3 , PRKCA P17252 PHLPP1 , PHLPP2 , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , PRKACA P17612 PPP2CA , PPP2CB , PLCG1 P19174 PTPN1 , PTPRJ , ELK1 P19419 PPP3CA , PPP3CB , PPP3CC , FLNA P21333 PPP3CA , PPP3CB , PPP3CC , CBL P22681 PTPRJ , UBASH3B , RPS6KB1 P23443 PPP2CA , PPP2CB , PHLPP1 , PHLPP2 , MSN P26038 PPM1A , PPM1B , MAPK3 P27361 CDC25A , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP9 , DUSP23 , PTPRE , PTPRJ , DUSP3 , PPP2CA , PTPRR , DUSP14 , PIK3R1 P27986 PPM1A , PTPRJ , MAPK1 P28482 CDC25A , DUSP22 , DUPD1 , PTPN7 , DUSP5 , DUSP1 , DUSP4 , DUSP6 , DUSP9 , DUSP7 , DUSP2 , PPP2CA , PPP2CB , PTPRE , PTPRJ , DUSP3 , PTPRR , PTPN6 P29350 PTPN1 , AKT1 P31749 ACP1 , PHLPP1 , PHLPP2 , PPP2CA , PPP2CB , PPP1CA , PPP1CB , PPP1CC , CTDSP1 , AKT2 P31751 PHLPP1 , PHLPP2 , CTNNB1 P35222 PTPN23 , PTPRF , ACP1 , PTPN14 , PTPN1 , PTPRU , PTPRK , DUSP23 , KDR P35968 ACP1 , PTPRB , PTPRJ , PTPN6 , PTPN11 , PTPN2 , STAT3 P40763 DUSP22 , PTPN1 , PTPRD , PTPRT , PTPN2 , CASP3 P42574 PPP2CA , PPP2CB , PXN P49023 PPP2CA , PPP2CB , PTPRT , PTPN11 , MAPK12 P53778 PTPN3 , PPP1CA P62136 PPP1CA , MDM2 Q00987 PPP2CA , PPP2CB , PPM1D , MAP2K1 Q02750 PPP2CA , PPP2CB , CAV1 Q03135 PTPN1 , PTPN2 , PTK2 Q05397 PTPN23 , ACP1 , PPP1CA , PPP1CB , PPP1CC , PTEN , PTPN1 , PTPN12 , UBASH3B , PTPN11 Q06124 PTPN1 , PAK1 Q13153 PPM1F , PPM1E , PPP2CA , PPP2CB , PPM1A , GAB1 Q13480 PTPN1 , PTPN11 , CAMK2B Q13554 PPP2CA , PPP2CB , CAMK2G Q13555 PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , CTDSPL , CTTN Q14247 PTPN1 , ERBB4 Q15303 ACP4 , PTPN6 , PTPN11 , SMAD2 Q15796 PPM1A , CTDSP1 , CTDSP2 , CTDSPL , MAPK14 Q16539 DUSP22 , DUPD1 , PTPN7 , DUSP8 , DUSP1 , DUSP9 , DUSP10 , DUSP2 , PPP2CA , PPP2CB , PPM1A , PPM1D , DUSP26 , DUSP3 , DUSP14 , SMO Q99835 PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , CAMK2A Q9UQM7 PPM1F , PPP1CA , PPP1CB , PPP1CC , PPP2CA , PPP2CB , AKT3 Q9Y243 PHLPP1 , PHLPP2 , PPP2CA , PPP2CB ,
Non-protein substrates involved in this pathway are unknown (yet!)
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