DEPOD - human DEPhOsphorylation Database

Basic Information
Phosphatases
Pathway
Interacting Proteins
Phosphorylating Kinases

Gene Name	MYC (QuickGO)	Interactive visualization of MYC structures (A quick tutorial to explore the interctive visulaization) Representative structure: 1EE4
Synonyms	MYC, BHLHE39
Protein Name	MYC
Alternative Name(s)	Myc proto-oncogene protein;Class E basic helix-loop-helix protein 39;bHLHe39;Proto-oncogene c-Myc;Transcription factor p64;
Protein Family	noSimilarity_annotations
EntrezGene ID	4609 (Comparitive Toxicogenomics)
UniProt AC (Human)	P01106 (protein sequence)
Enzyme Class	N/A
Molecular Weight	48804 Dalton
Protein Length	439 amino acids (AA)
Genome Browsers	NCBI \| ENSG00000136997 (Ensembl) \| UCSC
Crosslinking annotations	Query our ID-mapping table
Orthologues	Quest For Orthologues (QFO) \| GeneTree \| eggNOG - ENOG410IFSM \| eggNOG - ENOG41124Q3
Phosphorylation Network	Visualize

Domain organization, Expression, Diseases

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Localization, Function, Catalytic activity and Sequence

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Motif information from Eukaryotic Linear Motif atlas (ELM)

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Gene Ontology (P: Process; F: Function and C: Component terms)

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GO:0000082	P:G1/S transition of mitotic cell cycle
GO:0000122	P:negative regulation of transcription by RNA polymerase II
GO:0000165	P:MAPK cascade
GO:0000790	C:nuclear chromatin
GO:0000978	F:RNA polymerase II proximal promoter sequence-specific DNA binding
GO:0000981	F:RNA polymerase II transcription factor activity
GO:0001077	sequence-specific DNA binding
GO:0001658	F:transcriptional activator activity
GO:0002053	RNA polymerase II proximal promoter sequence-specific DNA binding
GO:0003677	P:branching involved in ureteric bud morphogenesis
GO:0003700	P:positive regulation of mesenchymal cell proliferation
GO:0005634	F:DNA binding
GO:0005654	F:DNA-binding transcription factor activity
GO:0005730	C:nucleus
GO:0006112	C:nucleoplasm
GO:0006338	C:nucleolus
GO:0006357	P:energy reserve metabolic process
GO:0006879	P:chromatin remodeling
GO:0006974	P:regulation of transcription by RNA polymerase II
GO:0007050	P:cellular iron ion homeostasis
GO:0007219	P:cellular response to DNA damage stimulus
GO:0008134	P:cell cycle arrest
GO:0008284	P:Notch signaling pathway
GO:0010332	F:transcription factor binding
GO:0010468	P:positive regulation of cell proliferation
GO:0010628	P:response to gamma radiation
GO:0015671	P:regulation of gene expression
GO:0016579	P:positive regulation of gene expression
GO:0019221	P:oxygen transport
GO:0032204	P:protein deubiquitination
GO:0032873	P:cytokine-mediated signaling pathway
GO:0032986	P:regulation of telomere maintenance
GO:0032991	P:negative regulation of stress-activated MAPK cascade
GO:0033613	P:protein-DNA complex disassembly
GO:0034644	C:protein-containing complex
GO:0035690	F:activating transcription factor binding
GO:0042493	P:cellular response to UV
GO:0043066	P:cellular response to drug
GO:0043280	P:response to drug
GO:0044346	P:negative regulation of apoptotic process
GO:0044877	P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045656	P:fibroblast apoptotic process
GO:0045893	F:protein-containing complex binding
GO:0045944	P:negative regulation of monocyte differentiation
GO:0046983	P:positive regulation of transcription
GO:0048146	DNA-templated
GO:0048147	P:positive regulation of transcription by RNA polymerase II
GO:0050679	F:protein dimerization activity
GO:0051276	P:positive regulation of fibroblast proliferation
GO:0051782	P:negative regulation of fibroblast proliferation
GO:0051973	P:positive regulation of epithelial cell proliferation
GO:0070371	P:chromosome organization
GO:0070491	P:negative regulation of cell division
GO:0070848	P:positive regulation of telomerase activity
GO:0070888	P:ERK1 and ERK2 cascade
GO:0071456	F:repressing transcription factor binding
GO:0090096	P:response to growth factor
GO:1904837	F:E-box binding
GO:2000573	P:cellular response to hypoxia
GO:2001022	P:positive regulation of metanephric cap mesenchymal cell proliferation

KEGG Pathway
Reactome Pathway

Pathway ID	Pathway Name	Pathway Description (KEGG)
hsa04010	MAPK signaling pathway	The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
hsa04012	ErbB signaling pathway	The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. Signaling effectors containing binding pockets for pY-containing peptides are recruited to activated receptors and induce the various signaling pathways. The Shc- and/or Grb2-activated mitogen-activated protein kinase (MAPK) pathway is a common target downstream of all ErbB receptors. Similarly, the phosphatidylinositol-3-kinase (PI-3K) pathway is directly or indirectly activated by most ErbBs. Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kinase Src, or the Cbl E3 ubiquitin protein ligase.
hsa04110	Cell cycle	Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
hsa04151	PI3K-Akt signaling pathway	The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
hsa04218	Cellular senescence	Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
hsa04310	Wnt signaling pathway	Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
hsa04350	TGF-beta signaling pathway	The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
hsa04390	Hippo signaling pathway	Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor Salvador and LATS1 and LATS2. In response to high cell densities, activated LATS1/2 phosphorylates the transcriptional coactivators YAP and TAZ, promoting its cytoplasmic localization, leading to cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated at low cell density, YAP/TAZ translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. YAP/TAZ also interacts with other transcriptional factors or signaling molecules, by which Hippo pathway-mediated processes are interconnected with those of other key signaling cascades, such as those mediated by TGF-beta and Wnt growth factors.
hsa04550	Signaling pathways regulating pluripotency of stem cells	Pluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date include embryonic stem (ES) and induced pluripotent stem (iPS) cells. ES cells are derived from the inner cell mass (ICM) of blastocyst-stage embryos. iPS cells are generated by reprogramming somatic cells back to pluripotent state with defined reprogramming factors, Oct4, Sox2, Klf4 and c-Myc (also known as Yamanaka factors). PSCs including ES cells and iPS cells are categorized into two groups by their morphology, gene expression profile and external signal dependence. Conventional mouse-type ES/iPS cells are called 'naive state' cells. They are mainly maintained under the control of LIF and BMP signaling. On the other hand, human-type ES/iPS cells, which are in need of Activin and FGF signaling, are termed 'primed state'. However, these signaling pathways converge towards the activation of a core transcriptional network that is similar in both groups and involves OCt4, Nanog and Sox2. The three transcription factors and their downstream target genes coordinately promote self-renewal and pluripotency.
hsa04630	Jak-STAT signaling pathway	The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
hsa04919	Thyroid hormone signaling pathway	The thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) and T3 enter the cell through transporter proteins. Although the major form of TH in the blood is T4, it is converted to the more active hormone T3 within cells. T3 binds to nuclear thyroid hormone receptors (TRs), which functions as a ligand-dependent transcription factor and controls the expression of target genes (genomic action). Nongenomic mechanisms of action is initiated at the integrin receptor. The plasma membrane alpha(v)beta(3)-integrin has distinct binding sites for T3 and T4. One binding site binds only T3 and activates the phosphatidylinositol 3-kinase (PI3K) pathway. The other binding site binds both T3 and T4 and activates the ERK1/2 MAP kinase pathway.
hsa05161	Hepatitis B	Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and converted into a covalently closed circular molecule cccDNA. The cccDNA is the template for transcription of all viral RNAs including the pregenomic RNA (pgRNA), encoding for 7 viral proteins: large, middle, and small envelope proteins (LHBs, MHBs, and SHBs) that form the surface antigen (HBsAg), the core antigen (HBcAg), the e antigen (HBeAg), the HBV polymerase, and the regulatory protein X (HBx). The pgRNA interacts with the viral polymerase protein to initiate the encapsidation into the core particles. Through endoplasmic reticulum, the core particles finish assembling with the envelope proteins and are released. HBV infection leads to a wide spectrum of liver diseases raging from chronic hepatitis, cirrhosis to hepatocellular carcinoma. The mechanism of liver injury is still not clear. However, HBV proteins target host proteins, involved in a variety of functions, thus regulating transcription, cellular signaling cascades, proliferation, differentiation, and apoptosis.
hsa05163	Human cytomegalovirus infection	Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
hsa05166	Human T-cell leukemia virus 1 infection	Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, SRF, and NFAT.
hsa05167	Kaposi sarcoma-associated herpesvirus infection	Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
hsa05169	Epstein-Barr virus infection	Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases. EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
hsa05200	Pathways in cancer
hsa05202	Transcriptional misregulation in cancer	In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
hsa05205	Proteoglycans in cancer	Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR: 00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
hsa05206	MicroRNAs in cancer	MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
hsa05210	Colorectal cancer	Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined oncogenes and tumour suppressor genes (TSG). Two major mechanisms of genomic instability have been identified in sporadic CRC progression. The first, known as chromosomal instability (CIN), results from a series of genetic changes that involve the activation of oncogenes such as K-ras and inactivation of TSG such as p53, DCC/Smad4, and APC. The second, known as microsatellite instability (MSI), results from inactivation of the DNA mismatch repair genes MLH1 and/or MSH2 by hypermethylation of their promoter, and secondary mutation of genes with coding microsatellites, such as transforming growth factor receptor II (TGF-RII) and BAX. Hereditary syndromes have germline mutations in specific genes (mutation in the tumour suppressor gene APC on chromosome 5q in FAP, mutated DNA mismatch repair genes in HNPCC).
hsa05213	Endometrial cancer	Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
hsa05216	Thyroid cancer	Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells. Their behavior varies from the indolent growing, well-differentiated papillary and follicular carcinomas (PTC and FTC, respectively) to the extremely aggressive undifferentiated carcinoma (UC). Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages. The most distinctive molecular features of FTC are the prominence of aneuploidy and the high prevalence of RAS mutations and PAX8-PPAR{gamma} rearrangements. p53 seems to play a crucial role in the dedifferentiation process of thyroid carcinoma.
hsa05219	Bladder cancer	The urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carcinoma are bladder carcinomas, and urothelial carcinomas of the renal pelvis and ureter account for only approximately 7% of the total. Urothelial tumours arise and evolve through divergent phenotypic pathways. Some tumours progress from urothelial hyperplasia to low-grade non-invasive superficial papillary tumours. More aggressive variants arise either from flat, high-grade carcinoma in situ (CIS) and progress to invasive tumours, or they arise de novo as invasive tumours. Low-grade papillary tumors frequently show a constitutive activation of the receptor tyrosine kinase-Ras pathway, exhibiting activating mutations in the HRAS and fibroblast growth factor receptor 3 (FGFR3) genes. In contrast, CIS and invasive tumors frequently show alterations in the TP53 and RB genes and pathways. Invasion and metastases are promoted by several factors that alter the tumour microenvironment, including the aberrant expression of E-cadherins (E-cad), matrix metalloproteinases (MMPs), angiogenic factors such as vascular endothelial growth factor (VEGF).
hsa05220	Chronic myeloid leukemia	Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (CP), which is characterized by expansion of functionally normal myeloid cells, followed by an accelerated phase (AP) and finally a more aggressive blast phase (BP), with loss of terminal differentiation capacity. On the cellular level, CML is associated with a specific chromosome abnormality, the t(9; 22) reciprocal translocation that forms the Philadelphia (Ph) chromosome. The Ph chromosome is the result of a molecular rearrangement between the c-ABL proto-oncogene on chromosome 9 and the BCR (breakpoint cluster region) gene on chromosome 22. The BCR/ABL fusion gene encodes p210 BCR/ABL, an oncoprotein, which, unlike the normal p145 c-Abl, has constitutive tyrosine kinase activity and is predominantly localized in the cytoplasm. While fusion of c-ABL and BCR is believed to be the primary cause of the chronic phase of CML, progression to blast crisis requires other molecular changes. Common secondary abnormalities include mutations in TP53, RB, and p16/INK4A, or overexpression of genes such as EVI1. Additional chromosome translocations are also observed,such as t(3;21)(q26;q22), which generates AML1-EVI1.
hsa05221	Acute myeloid leukemia	Acute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation program. AML accounts for approximately 80% of all adult leukemias and remains the most common cause of leukemia death. Two major types of genetic events have been described that are crucial for leukemic transformation. A proposed necessary first event is disordered cell growth and upregulation of cell survival genes. The most common of these activating events were observed in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sporadically in other RTKs. Alterations in myeloid transcription factors governing hematopoietic differentiation provide second necessary event for leukemogenesis. Transcription factor fusion proteins such as AML-ETO, PML-RARalpha or PLZF-RARalpha block myeloid cell differentiation by repressing target genes. In other cases, the transcription factors themselves are mutated.
hsa05222	Small cell lung cancer	Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control.
hsa05224	Breast cancer	Breast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gland. The molecular subtypes of breast cancer, which are based on the presence or absence of hormone receptors (estrogen and progesterone subtypes) and human epidermal growth factor receptor-2 (HER2), include: hormone receptor positive and HER2 negative (luminal A subtype), hormone receptor positive and HER2 positive (luminal B subtype), hormone receptor negative and HER2 positive (HER2 positive), and hormone receptor negative and HER2 negative (basal-like or triple-negative breast cancers (TNBCs)). Hormone receptor positive breast cancers are largely driven by the estrogen/ER pathway. In HER2 positive breast tumours, HER2 activates the PI3K/AKT and the RAS/RAF/MAPK pathways, and stimulate cell growth, survival and differentiation. In patients suffering from TNBC, the deregulation of various signalling pathways (Notch and Wnt/beta-catenin), EGFR protein have been confirmed. In the case of breast cancer only 8% of all cancers are hereditary, a phenomenon linked to genetic changes in BRCA1 or BRCA2. Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers.
hsa05225	Hepatocellular carcinoma	Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.
hsa05226	Gastric cancer	Gastric cancer (GC) is one of the world's most common cancers. According to Lauren's histological classification gastric cancer is divided into two distinct histological groups - the intestinal and diffuse types. Several genetic changes have been identified in intestinal-type GC. The intestinal metaplasia is characterized by mutations in p53 gene, reduced expression of retinoic acid receptor beta (RAR-beta) and hTERT expression. Gastric adenomas furthermore display mutations in the APC gene, reduced p27 expression and cyclin E amplification. In addition, amplification and overexpression of c-ErbB2, reduced TGF-beta receptor type I (TGFBRI) expression and complete loss of p27 expression are commonly observed in more advanced GC. The main molecular changes observed in diffuse-type GCs include loss of E-cadherin function by mutations in CDH1 and amplification of MET and FGFR2F.
hsa05230	Central carbon metabolism in cancer	Malignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamental differences in the central metabolic pathways operating in malignant tissue. He showed that cancer cells consume a large amount of glucose, maintain high rate of glycolysis and convert a majority of glucose into lactic acid even under normal oxygen concentrations (Warburg's Effects). More recently, it has been recognized that the 'Warburg effect' encompasses a similarly increased utilization of glutamine. From the intermediate molecules provided by enhanced glycolysis and glutaminolysis, cancer cells synthesize most of the macromolecules required for the duplication of their biomass and genome. These cancer-specific alterations represent a major consequence of genetic mutations and the ensuing changes of signalling pathways in cancer cells. Three transcription factors, c-MYC, HIF-1 and p53, are key regulators and coordinate regulation of cancer metabolism in different ways, and many other oncogenes and tumor suppressor genes cluster along the signaling pathways that regulate c-MYC, HIF-1 and p53.

Pathway ID	Pathway Name	Pathway Description (KEGG)
R-HSA-1362277	Transcription of E2F targets under negative control by DREAM complex.	DREAM complex is evolutionarily conserved and is reponsible for transcriptional repressession of cell cycle-regulated genes in G0 and early G1
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription.	NICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 displaces the NCOR corepressor complex from RBPJ (CSL). When bound to the co-repressor complex that includes NCOR proteins (NCOR1 and NCOR2) and HDAC histone deacetylases, RBPJ (CSL) represses transcription of NOTCH target genes (Kao et al. 1998, Zhou et al. 2000, Perissi et al. 2004, Perissi et al. 2008). Once the co-repressor complex is displaced, NICD1 recruits MAML (mastermind-like) to RBPJ, while MAML recruits histone acetyltransferases EP300 (p300) and PCAF, resulting in formation of the NOTCH coactivator complex that activates transcription from NOTCH regulatory elements. The minimal functional NOTCH coactivator complex that activates transcription from NOTCH regulatory elements is a heterotrimer composed of NICD, MAML and RBPJ (Fryer et al. 2002, Wallberg et al. 2002, Nam et al. 2006). NOTCH1 coactivator complex is known to activate transcription of HES1 (Jarriault et al. 1995), HES5 (Arnett et al. 2010), HEY genes (Fischer et al. 2004, Leimeister et al. 2000, Maier et al. 2000, Arnett et al. 2010) and MYC (Palomero et al. 2006) and likely regulates transcription of many other genes (Wang et al. 2011). NOTCH1 coactivator complex on any specific regulatory element may involve additional transcriptional regulatory proteins. HES1 binds TLE proteins, forming an evolutionarily conserved transcriptional corepressor involved in regulation of neurogenesis, segmentation and sex determination (Grbavec et al. 1996, Fisher et al. 1996, Paroush et al. 1994). After NOTCH1 coactivator complex is assembled on a NOTCH-responsive promoter, MAML (mastermind-like) recruits CDK8 in complex with cyclin C, triggering phosphorylation of conserved serine residues in TAD and PEST domains of NICD1 by CDK8. Phosphorylated NICD1 is recognized by the E3 ubiquitin ligase FBXW7 which ubiquitinates NICD1, leading to degradation of NICD1 and downregulation of NOTCH1 signaling. FBXW7-mediated ubiquitination and degradation of NOTCH1 depend on C-terminally located PEST domain sequences in NOTCH1 (Fryer et al. 2004, Oberg et al. 2001, Wu et al. 2001). The PEST domain of NOTCH1 and the substrate binding WD40 domain of FBXW7 are frequent targets of mutations in T-cell acute lymphoblastic leukemia - T-ALL (Welcker and Clurman 2008). NICD1, which normally has a short half-life, can be stabilized by binding to the hypoxia-inducable factor 1-alpha (HIF1A) which accumulates in the nucleus when oxygen levels are low. This results in HIF1A-induced inhibition of cellular differentiation that is NOTCH-dependent (Gustafsson et al. 2005)
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.	After phosphorylated SMAD2 and/or SMAD3 form a heterotrimer with SMAD4, SMAD2/3:SMAD4 complex translocates to the nucleus (Xu et al. 2000, Kurisaki et al. 2001, Xiao et al. 2003). In the nucleus, linker regions of SMAD2 and SMAD3 within SMAD2/3:SMAD4 complex can be phosphorylated by CDK8 associated with cyclin C (CDK8:CCNC) or CDK9 associated with cyclin T (CDK9:CCNT). CDK8/CDK9-mediated phosphorylation of SMAD2/3 enhances transcriptional activity of SMAD2/3:SMAD4 complex, but also primes it for ubiquitination and consequent degradation (Alarcon et al. 2009). The transfer of SMAD2/3:SMAD4 complex to the nucleus can be assisted by other proteins, such as WWTR1. In human embryonic cells, WWTR1 (TAZ) binds SMAD2/3:SMAD4 heterotrimer and mediates TGF-beta-dependent nuclear accumulation of SMAD2/3:SMAD4. The complex of WWTR1 and SMAD2/3:SMAD4 binds promoters of SMAD7 and SERPINE1 (PAI-1 i.e. plasminogen activator inhibitor 1) genes and stimulates their transcription (Varelas et al. 2008). Stimulation of SMAD7 transcription by SMAD2/3:SMAD4 represents a negative feedback loop in TGF-beta receptor signaling. SMAD7 can be downregulated by RNF111 ubiquitin ligase (Arkadia), which binds and ubiquitinates SMAD7, targeting it for degradation (Koinuma et al. 2003). SMAD2/3:SMAD4 heterotrimer also binds the complex of RBL1 (p107), E2F4/5 and TFDP1/2 (DP1/2). The resulting complex binds MYC promoter and inhibits MYC transcription. Inhibition of MYC transcription contributes to anti-proliferative effect of TGF-beta (Chen et al. 2002). SMAD2/3:SMAD4 heterotrimer also associates with transcription factor SP1. SMAD2/3:SMAD4:SP1 complex stimulates transcription of a CDK inhibitor CDKN2B (p15-INK4B), also contributing to the anti-proliferative effect of TGF-beta (Feng et al. 2000). MEN1 (menin), a transcription factor tumor suppressor mutated in a familial cancer syndrome multiple endocrine neoplasia type 1, forms a complex with SMAD2/3:SMAD4 heterotrimer, but transcriptional targets of SMAD2/3:SMAD4:MEN1 have not been elucidated (Kaji et al. 2001, Sowa et al. 2004, Canaff et al. 2012). JUNB is also an established transcriptional target of SMAD2/3:SMAD4 complex (Wong et al. 1999)
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants.	As NOTCH1 PEST domain is intracellular, NOTCH1 PEST domain mutants are expected to behave as the wild-type NOTCH1 with respect to ligand binding and proteolytic cleavage mediated activation of signaling. However, once the NICD1 fragment of NOTCH1 is released, PEST domain mutations prolong its half-life and transcriptional activity through interference with FBXW7 (FBW7)-mediated ubiquitination and degradation of NICD1 (Weng et al. 2004, Thompson et al. 2007, O'Neil et al. 2007). All NOTCH1 PEST domain mutants annotated here (NOTCH1 Q2395, NOTCH1 Q2440, NOTCH1 P2474Afs4 and NOTCH1 P2514Rfs4) either have a truncated PEST domain or lack the PEST domain completely
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.	When found in cis, HD and PEST domain mutations act synergistically, increasing NOTCH1 transcriptional activity up to ~40-fold, compared with up to ~10-fold and up to ~2-fold increase with HD mutations alone and PEST domain mutations alone, respectively (Weng et al. 2004). HD domain mutations enable spontaneous, ligand-independent, proteolytic release of the NICD1 fragment, although mutants remain responsive to ligand binding (Malecki et al. 2006), while PEST domain mutations prolong NICD1 half-life and transcriptional activity through interference with FBXW7 (FBW7)-mediated ubiquitination and degradation (Thompson et al. 2007, O'Neil et al. 2007). NOTCH1 HD+PEST domain mutants annotated here are NOTCH1 L1600P;P2514Rfs4, NOTCH1 L1600P;Q2440, NOTCH1 L1600P;Q2395* and NOTCH1 L1574P;P2474Afs*4
R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters.	The genes regulated by beta-catenin and TCF/LEF are involved in a diverse range of functions in cellular proliferation, differentiation, embryogenesis and tissue homeostasis, and include transcription factors, cell cycle regulators, growth factors, proteinases and inflammatory cytokines, among others (reviewed in Vlad et al, 2008). A number of WNT signaling components are themselves positively or negatively regulated targets of TCF/LEF-dependent transcription, establishing feedback loops to enhance or restrict signaling (see for instance, Khan et al 2007; Chamorro et al, 2005; Roose et al, 1999; Lustig et al, 2002). Other than a few of these general feedback targets (e.g. Axin2), most target genes are cell- and/or tissue-specific. A list of WNT/beta-catenin-dependent target genes is maintained at http://www.standford.edu/group/nusselab/cgi-bin/wnt/target_genes
R-HSA-5687128	MAPK6/MAPK4 signaling.	MAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classified as such based on their lack of activation by MAPKK family members. Unlike the conventional MAPK proteins, which contain a Thr-X-Tyr motif in the activation loop, MAPK6 and 4 have a single Ser-Glu-Gly phospho-acceptor motif (reviewed in Coulombe and Meloche, 2007; Cargnello et al, 2011). MAPK6 is also distinct in being an unstable kinase, whose turnover is mediated by ubiquitin-dependent degradation (Coulombe et al, 2003; Coulombe et al, 2004). The biological functions and pathways governing MAPK6 and 4 are not well established. MAPK6 and 4 are phosphorylated downstream of class I p21 activated kinases (PAKs) in a RAC- or CDC42-dependent manner (Deleris et al, 2008; Perander et al, 2008; Deleris et al, 2011; De La Mota-Peynado et al, 2011). One of the only well established substrates of MAPK6 and 4 is MAPKAPK5, which contributes to cell motility by promoting the HSBP1-dependent rearrangement of F-actin (Gerits et al, 2007; Kostenko et al, 2009a; reviewed in Kostenko et al, 2011b). The atypical MAPKs also contribute to cell motility and invasiveness through the NCOA3:ETV4-dependent regulation of MMP gene expression (Long et al, 2012; Yan et al, 2008; Qin et al, 2008)
R-HSA-5689880	Ub-specific processing proteases.	Ub-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved motifs with N- or C-terminal extensions and insertions occurring between the conserved motifs (Ye et al. 2009). Two highly conserved regions comprise the catalytic triad, the Cys-box (Cys) and His-box (His and Asp/Asn) (Nijman et al. 2005, Ye et al. 2009, Reyes-Turcu & Wilkinson 2009). They recognize their substrates by interactions of the variable regions with the substrate protein directly, or via scaffolds or adapters in multiprotein complexes
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling.	Interleukin-4 (IL4) is a principal regulatory cytokine during the immune response, crucially important in allergy and asthma (Nelms et al. 1999). When resting T cells are antigen-activated and expand in response to Interleukin-2 (IL2), they can differentiate as Type 1 (Th1) or Type 2 (Th2) T helper cells. The outcome is influenced by IL4. Th2 cells secrete IL4, which both stimulates Th2 in an autocrine fashion and acts as a potent B cell growth factor to promote humoral immunity (Nelms et al. 1999). Interleukin-13 (IL13) is an immunoregulatory cytokine secreted predominantly by activated Th2 cells. It is a key mediator in the pathogenesis of allergic inflammation. IL13 shares many functional properties with IL4, stemming from the fact that they share a common receptor subunit. IL13 receptors are expressed on human B cells, basophils, eosinophils, mast cells, endothelial cells, fibroblasts, monocytes, macrophages, respiratory epithelial cells, and smooth muscle cells, but unlike IL4, not T cells. Thus IL13 does not appear to be important in the initial differentiation of CD4 T cells into Th2 cells, rather it is important in the effector phase of allergic inflammation (Hershey et al. 2003).\n\nIL4 and IL13 induce “alternative activation” of macrophages, inducing an anti-inflammatory phenotype by signaling through IL4R alpha in a STAT6 dependent manner. This signaling plays an important role in the Th2 response, mediating anti-parasitic effects and aiding wound healing (Gordon & Martinez 2010, Loke et al. 2002)\n\nThere are two types of IL4 receptor complex (Andrews et al. 2006). Type I IL4R (IL4R1) is predominantly expressed on the surface of hematopoietic cells and consists of IL4R and IL2RG, the common gamma chain. Type II IL4R (IL4R2) is predominantly expressed on the surface of nonhematopoietic cells, it consists of IL4R and IL13RA1 and is also the type II receptor for IL13. (Obiri et al. 1995, Aman et al. 1996, Hilton et al. 1996, Miloux et al. 1997, Zhang et al. 1997). The second receptor for IL13 consists of IL4R and Interleukin-13 receptor alpha 2 (IL13RA2), sometimes called Interleukin-13 binding protein (IL13BP). It has a high affinity receptor for IL13 (Kd = 250 pmol/L) but is not sufficient to render cells responsive to IL13, even in the presence of IL4R (Donaldson et al. 1998). It is reported to exist in soluble form (Zhang et al. 1997) and when overexpressed reduces JAK-STAT signaling (Kawakami et al. 2001). It's function may be to prevent IL13 signalling via the functional IL4R:IL13RA1 receptor. IL13RA2 is overexpressed and enhances cell invasion in some human cancers (Joshi & Puri 2012).The first step in the formation of IL4R1 (IL4:IL4R:IL2RB) is the binding of IL4 with IL4R (Hoffman et al. 1995, Shen et al. 1996, Hage et al. 1999). This is also the first step in formation of IL4R2 (IL4:IL4R:IL13RA1). After the initial binding of IL4 and IL4R, IL2RB binds (LaPorte et al. 2008), to form IL4R1. Alternatively, IL13RA1 binds, forming IL4R2. In contrast, the type II IL13 complex (IL13R2) forms with IL13 first binding to IL13RA1 followed by recruitment of IL4R (Wang et al. 2009).Crystal structures of the IL4:IL4R:IL2RG, IL4:IL4R:IL13RA1 and IL13:IL4R:IL13RA1 complexes have been determined (LaPorte et al. 2008). Consistent with these structures, in monocytes IL4R is tyrosine phosphorylated in response to both IL4 and IL13 (Roy et al. 2002, Gordon & Martinez 2010) while IL13RA1 phosphorylation is induced only by IL13 (Roy et al. 2002, LaPorte et al. 2008) and IL2RG phosphorylation is induced only by IL4 (Roy et al. 2002).Both IL4 receptor complexes signal through Jak/STAT cascades. IL4R is constitutively-associated with JAK2 (Roy et al. 2002) and associates with JAK1 following binding of IL4 (Yin et al. 1994) or IL13 (Roy et al. 2002). IL2RG constitutively associates with JAK3 (Boussiotis et al. 1994, Russell et al. 1994). IL13RA1 constitutively associates with TYK2 (Umeshita-Suyama et al. 2000, Roy et al. 2002, LaPorte et al. 2008, Bhattacharjee et al. 2013). IL4 binding to IL4R1 leads to phosphorylation of JAK1 (but not JAK2) and STAT6 activation (Takeda et al. 1994, Ratthe et al. 2007, Bhattacharjee et al. 2013). IL13 binding increases activating tyrosine-99 phosphorylation of IL13RA1 but not that of IL2RG. IL4 binding to IL2RG leads to its tyrosine phosphorylation (Roy et al. 2002). IL13 binding to IL4R2 leads to TYK2 and JAK2 (but not JAK1) phosphorylation (Roy & Cathcart 1998, Roy et al. 2002).Phosphorylated TYK2 binds and phosphorylates STAT6 and possibly STAT1 (Bhattacharjee et al. 2013). A second mechanism of signal transduction activated by IL4 and IL13 leads to the insulin receptor substrate (IRS) family (Kelly-Welch et al. 2003). IL4R1 associates with insulin receptor substrate 2 and activates the PI3K/Akt and Ras/MEK/Erk pathways involved in cell proliferation, survival and translational control. IL4R2 does not associate with insulin receptor substrate 2 and consequently the PI3K/Akt and Ras/MEK/Erk pathways are not activated (Busch-Dienstfertig & González-Rodríguez 2013)
R-HSA-69202	Cyclin E associated events during G1/S transition.	The transition from the G1 to S phase is controlled by the Cyclin E:Cdk2 complexes. As the Cyclin E:Cdk2 complexes are formed, the Cdk2 is phosphorylated by the Wee1 and Myt1 kinases. This phosphorylation keeps the Cdk2 inactive. In yeast this control is called the cell size checkpoint control. The dephosphorylation of the Cdk2 by Cdc25A activates the Cdk2, and is coordinated with the cells reaching the proper size, and with the DNA synthesis machinery being ready. The Cdk2 then phosphorylates G1/S specific proteins, including proteins required for DNA replication initiation. The beginning of S-phase is marked by the first nucleotide being laid down on the primer during DNA replication at the early-firing origins.Failure to appropriately regulate cyclin E accumulation can lead to accelerated S phase entry, genetic instability, and tumorigenesis. The amount of\n cyclin E protein in the cell is controlled by ubiquitin-mediated proteolysis (see Woo, 2003).This pathway has not yet been annotated in Reactome
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry.	Cyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. During G1 phase of the cell cycle, cyclin A is synthesized and associates with Cdk2. After forming in the cytoplasm, the Cyclin A:Cdk2 complexes are translocated to the nucleus (Jackman et al.,2002). Prior to S phase entry, the activity of Cyclin A:Cdk2 complexes is negatively regulated through Tyr 15 phosphorylation of Cdk2 (Gu et al., 1995) and also by the association of the cyclin kinase inhibitors (CKIs), p27 and p21. Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase (CAK) is required for the activation of the CDK2 kinase activity (Aprelikova et al., 1995). The entry into S phase is promoted by the removal of inhibitory Tyr 15 phosphates from the Cdk2 subunit of Cyclin A:Cdk2 complex by the Cdc25 phosphatases (Blomberg and Hoffmann, 1999) and by SCF(Skp2)-mediated degradation of p27/p21 (see Ganoth et al., 2001). \r\nWhile Cdk2 is thought to play a primary role in regulating entry into S phase, recent evidence indicates that Cdk1 is equally capable of promoting entry into S phase and the initiation of DNA replication (see Bashir and Pagano, 2005). Thus, Cdk1 complexes may also play a significant role at this point in the cell cycle
R-HSA-8866911	TFAP2 (AP-2) family regulates transcription of cell cycle factors.	TFAP2A and TFAP2C play opposing roles in transcriptional regulation of the CDKN1A (p21) gene locus. While TFAP2A stimulates transcription of the CDKN1A cyclin-dependent kinase inhibitor (Zeng et al. 1997, Williams et al. 2009, Scibetta et al. 2010), TFAP2C, in cooperation with MYC and histone demethylase KDM5B, represses CDKN1A transcription (Williams et al. 2009, Scibetta et al. 2010, Wong et al. 2012)
R-HSA-8951430	RUNX3 regulates WNT signaling.	RUNX3 binds to complexes of beta-catenin (CTNNB1) and TCF/LEF family members. Binding of RUNX3 to CTNNB1:TCF/LEF complexes prevents their loading onto cyclin D1 (CCND1) and MYC gene promoters and interferes with WNT signaling-mediated activation of CCND1 and MYC1 transcription. RUNX3 therefore inhibits WNT-induced cellular proliferation (Ito et al. 2008)
R-HSA-9018519	Estrogen-dependent gene expression.	Estrogens mediate their transcriptional effects through interaction with the estrogen receptors, ESR1 (also known as ER alpha) and ESR2 (ER beta). ESR1 and ESR2 share overlapping but distinct functions, with ESR1 playing the primary role in transcriptional activation in most cell types (Hah and Krauss, 2014; Haldosén et al, 2014. The receptors function as ligand-dependent dimers and can activate target genes either through direct binding to an estrogen responsive element (ERE) in the target gene promoter, or indirectly through interaction with another DNA-binding protein such as RUNX1, SP1, AP1 or NF-kappa beta (reviewed in Bai and Gust, 2009; Hah and Krause, 2014). Binding of estrogen receptors to the DNA promotes the assembly of higher order transcriptional complexes containing methyltransferases, histone acetyltransferases and other transcriptional activators, which promote transcription by establishing active chromatin marks and by recruiting general transcription factors and RNA polymerase II. ESR1- and estrogen-dependent recruitment of up to hundreds of coregulators has been demonstrated by varied co-immunoprecipitation and proteomic approaches (Kittler et al, 2013; Mohammed et al, 2013; Foulds et al, 2013; Mohammed et al, 2015; Liu et al, 2014; reviewed in Magnani and Lupien, 2014; Arnal, 2017). In some circumstances, ligand-bound receptors can also promote the assembly of a repression complex at a target gene, and in some cases, heterodimers of ESR1 and ESR2 serve as repressors of ESR1-mediated target gene activation (reviewed in Hah and Kraus, 2014; Arnal et al, 2017). Phosphorylation of the estrogen receptor also modulates its activity, and provides cross-talk between nuclear estrogen-dependent signaling and non-genomic estrogen signaling from the plasma membrane (reviewed in Anbalagan and Rowan, 2015; Halodsèn et al, 2014; Schwartz et al, 2016) A number of recent genome wide studies highlight the breadth of the transcriptional response to estrogen. The number of predicted estrogen-dependent target genes ranges from a couple of hundred (based on microarray studies) to upwards of 10000, based on ChIP-chip or ChIP-seq (Cheung and Kraus, 2010; Kinnis and Kraus, 2008; Lin et al, 2004; Welboren et al, 2009; Ikeda et al, 2015; Lin et al, 2007; Carroll et al, 2006). Many of these predicted sites may not represent transcriptionally productive binding events, however. A study examining ESR1 binding by ChIP-seq in 20 primary breast cancers identified a core of 484 ESR-binding events that were conserved in at least 75% of ER+ tumors, which may represent a more realistic estimate (Ross-Innes et al, 2012). These studies also highlight the long-range effect of estrogen receptor-binding, with distal enhancer or promoter elements regulating the expression of many target genes, often through looping or other higher order chromatin structures (Kittler et al, 2013; reviewed in Dietz and Carroll, 2008; Liu and Cheung, 2014; Magnani and Lupien, 2014). Transcription from a number of estrogen-responsive target genes also appears to be primed by the binding of pioneering transcription factors such as FOXA1, GATA3, PBX1 among others

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Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
ABCA2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
ACOT8	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ACTB	Co-purification	physical	11839798, (Europe PMC)	NA	BioGRID
ACTC1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
ACTG1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
ACTL6A	Affinity Capture-MS, Affinity Capture-Western, Co-purification, tandem affinity purification	association, physical	11839798, 17314511, 25609649, (Europe PMC)	0.53	BioGRID, IntAct, MINT
ACTL8	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
ADAR	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
ADIPOR1	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
ADNP	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
AFAP1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
AIFM2	Dosage Lethality, tandem affinity purification	association, genetic	21150319, 22623531, (Europe PMC)	0.35	BioGRID, IntAct
AKAP6	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
AKAP8	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
AKAP8L	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ALDH18A1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ALDH1B1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ALDOA	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
ALPK1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
AMBRA1	Affinity Capture-Western, anti bait coimmunoprecipitation	physical, physical association	25438055, (Europe PMC)	0.40	BioGRID, IntAct
ANGPTL4	Co-purification	physical	22573825, (Europe PMC)	NA	BioGRID
ANXA2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
APP	Reconstituted Complex	physical	21244100, (Europe PMC)	NA	BioGRID
ARF4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ARFGEF2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
ARHGEF2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
ARL1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ASS1	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
ATAD2	Affinity Capture-Western, Reconstituted Complex	physical	19843847, (Europe PMC)	NA	BioGRID
ATP5F1C	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
ATP5F1D	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
ATP5MF	Affinity Capture-MS	physical	17314511, 21150319, (Europe PMC)	NA	BioGRID
ATXN10	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
AXIN1	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association, direct interaction, physical, physical association	19131971, (Europe PMC)	0.62	BioGRID, IntAct, MINT
B4GALT7	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
BCL2	Affinity Capture-Western, Co-localization	physical	15210690, (Europe PMC)	NA	BioGRID
BCR	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
BIN1	Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, nuclear magnetic resonance, two hybrid	direct interaction, physical, physical association	10380878, 15992821, (Europe PMC)	0.51, 0.59	BioGRID, IntAct, MINT
BLM	Affinity Capture-Western, Reconstituted Complex	physical	23750012, (Europe PMC)	NA	BioGRID
BMPR1A	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
BNIP2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
BOK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
BRCA1	Affinity Capture-Western, Co-localization, Reconstituted Complex, Two-hybrid	physical	11916966, 12646176, 14612409, 20215511, 9788437, (Europe PMC)	NA	BioGRID
BRD3	Reconstituted Complex, display technology, tandem affinity purification	physical, physical association	20195357, (Europe PMC)	0.52	BioGRID, IntAct
BRD4	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
BRD8	Affinity Capture-MS	physical	20946988, (Europe PMC)	NA	BioGRID
BRPF1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
BTK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
BTRC	Affinity Capture-Western, Biochemical Activity	physical	20852628, (Europe PMC)	NA	BioGRID
C17orf49	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
C1QBP	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CALM1	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
CAMK1G	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CAMK2D	Affinity Capture-MS, Dosage Lethality, tandem affinity purification	association, genetic, physical	21150319, 22623531, (Europe PMC)	0.35	BioGRID, IntAct
CAMK2G	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CARM1	Affinity Capture-Western	physical	15616592, (Europe PMC)	NA	BioGRID
CAVIN1	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
CAVIN3	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
CBFB	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
CCAR2	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, cosedimentation through density gradient, tandem affinity purification, two hybrid	association, physical, physical association	17314511, 17353931, 22190494, (Europe PMC)	0.75	BioGRID, IntAct
CCNH	Reconstituted Complex	physical	11673469, (Europe PMC)	NA	BioGRID
CCNK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CCNT1	Affinity Capture-Western, Reconstituted Complex	physical	11673469, 12944920, 17700062, 19818711, (Europe PMC)	NA	BioGRID
CCT2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CCT3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CCT4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CCT5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CCT6A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CCT8	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CD6	Affinity Capture-Western	physical	10899308, (Europe PMC)	NA	BioGRID
CDC6	Reconstituted Complex	physical	10899308, (Europe PMC)	NA	BioGRID
CDC73	Affinity Capture-Western, Protein-peptide	physical	26687678, (Europe PMC)	NA	BioGRID
CDCA7L	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation	physical, physical association	15994933, 16829576, (Europe PMC)	0.40	BioGRID, IntAct
CDH5	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CDK12	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CDK16	Synthetic Lethality	genetic	25495526, (Europe PMC)	NA	BioGRID
CDK2	Dosage Lethality, Synthetic Lethality	genetic	22623531, 25495526, (Europe PMC)	NA	BioGRID
CDK4	Biochemical Activity, Two-hybrid, protein kinase assay, two hybrid array	phosphorylation reaction, physical, physical association	21988832, 22094256, (Europe PMC)	0.59	BioGRID, IntAct
CDK6	Biochemical Activity, protein kinase assay	phosphorylation reaction, physical	22094256, (Europe PMC)	0.44	BioGRID, IntAct
CDK8	Reconstituted Complex	physical	11673469, (Europe PMC)	NA	BioGRID
CDK9	Affinity Capture-Western, Reconstituted Complex	physical	11673469, 12944920, 17700062, 19818711, 26687678, (Europe PMC)	NA	BioGRID
CDKN1B	Affinity Capture-Western, PCA	physical	26701207, (Europe PMC)	NA	BioGRID
CDKN2A	Affinity Capture-Western	physical	17289033, 20308430, 23277542, (Europe PMC)	NA	BioGRID
CDR2	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	10465786, 20383333, (Europe PMC)	NA	BioGRID
CDYL	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
CEBPA	Affinity Capture-Western	physical	12873812, (Europe PMC)	NA	BioGRID
CEBPB	Affinity Capture-Western	physical	12873812, (Europe PMC)	NA	BioGRID
CECR2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CENPF	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
CENPO	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CEP57	Reconstituted Complex, display technology, tandem affinity purification	physical, physical association	20195357, (Europe PMC)	0.52	BioGRID, IntAct
CEPT1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CHCHD3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
CHD4	Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, (Europe PMC)	0.50	BioGRID, IntAct
CHD9	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
CHTF18	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CHUK	Affinity Capture-Western, anti bait coimmunoprecipitation, confocal microscopy	colocalization, physical, physical association	21575199, (Europe PMC)	0.46	BioGRID, IntAct
CIP2A	Affinity Capture-Western, Reconstituted Complex	physical	17632056, (Europe PMC)	NA	BioGRID
CKAP4	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
CNMD	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
COPG1	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
COPG2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CPS1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CRADD	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CREBBP	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid	physical	12776737, 16878156, (Europe PMC)	NA	BioGRID
CSE1L	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CSNK1E	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CSNK2A1	Biochemical Activity	physical	12149649, (Europe PMC)	NA	BioGRID
CTNND1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
CTPS1	Affinity Capture-MS, Dosage Lethality	genetic, physical	21150319, 22623531, (Europe PMC)	NA	BioGRID
CTR9	Affinity Capture-Western, tandem affinity purification	association, physical	21150319, 26687678, (Europe PMC)	0.35	BioGRID, IntAct
CTSD	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CUL1	Affinity Capture-Western	physical	12769844, (Europe PMC)	NA	BioGRID
CUL4A	Affinity Capture-Western	physical	20551172, (Europe PMC)	NA	BioGRID
CXXC1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CYC1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
CYR61	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DCAF8	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
DDB1	Affinity Capture-Western	physical	20551172, (Europe PMC)	NA	BioGRID
DDB2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
DDX1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DDX17	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
DDX20	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
DDX24	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17353931, 21150319, (Europe PMC)	0.56	BioGRID, IntAct
DDX52	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DHX15	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DIMT1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DMAP1	Affinity Capture-Western	physical	20946988, (Europe PMC)	NA	BioGRID
DNAJA2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DNAJA3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DNAJB11	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
DNAJB12	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
DNAJB6	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DNMT3A	Affinity Capture-Western, Reconstituted Complex	physical	15616584, 19786833, (Europe PMC)	NA	BioGRID
DPM1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
DYNC1H1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ECSIT	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
EEF1G	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
EFNA5	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
EFNB1	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
EFTUD2	Affinity Capture-MS, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, cosedimentation through density gradient, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.68	BioGRID, IntAct
EIF3I	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
EIF4A1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
EIF4ENIF1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ELAVL1	Affinity Capture-RNA	physical	19322201, (Europe PMC)	NA	BioGRID
ELF3	Biochemical Activity	physical	1651323, (Europe PMC)	NA	BioGRID
ELP1	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
EP300	Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation	physical, physical association	15616592, 16126174, 16287840, 17157259, (Europe PMC)	0.40	BioGRID, IntAct
EP400	Affinity Capture-MS, Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	association, physical, physical association	11509179, 17314511, 18413597, 20946988, 21150319, (Europe PMC)	0.40, 0.67	BioGRID, IntAct
EPC1	Affinity Capture-MS, tandem affinity purification	association, physical	20946988, 21150319, (Europe PMC)	0.35	BioGRID, IntAct
EPC2	Affinity Capture-MS	physical	20946988, (Europe PMC)	NA	BioGRID
ERBIN	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
ERC1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
ERCC3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ERN1	Synthetic Lethality	genetic	25495526, (Europe PMC)	NA	BioGRID
ESR1	Affinity Capture-Western	physical	16455494, (Europe PMC)	NA	BioGRID
ETFA	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ETV3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
EXOC4	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
EYA1	Affinity Capture-Western, Biochemical Activity	physical	27795300, (Europe PMC)	NA	BioGRID
FAM131C	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
FANCD2	Affinity Capture-MS, Co-localization, tandem affinity purification	association, physical	17314511, 24658369, (Europe PMC)	0.35	BioGRID, IntAct
FANCI	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
FBL	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
FBXO5	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
FBXO8	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex	physical	20848231, (Europe PMC)	NA	BioGRID
FBXW7	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	15103331, 15150404, 15498494, 17157259, 17314511, 17646408, 17873522, 20848231, 20970423, 22524983, 23750012, 25716680, 25720964, 27795300, 28007894, 28209614, (Europe PMC)	NA	BioGRID
FBXW8	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid	association, physical, physical association	17314511, (Europe PMC)	0.57	BioGRID, IntAct
FHL2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
FLNA	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
FN1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
FOSL1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
FOXO3	Affinity Capture-Western	physical	18393360, (Europe PMC)	NA	BioGRID
FOXO6	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
FOXP1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
FOXR1	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, 26186194, 28514442, (Europe PMC)	0.35	BioGRID, IntAct, MINT
FOXR2	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, 26186194, 28514442, (Europe PMC)	0.35	BioGRID, IntAct, MINT
GALR3	Affinity Capture-MS	physical	20848231, (Europe PMC)	NA	BioGRID
GANAB	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
GCDH	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
GCHFR	Affinity Capture-MS	physical	20848231, (Europe PMC)	NA	BioGRID
GCN1	Affinity Capture-MS, Two-hybrid	physical	17314511, 17353931, 20936779, (Europe PMC)	NA	BioGRID
GEMIN4	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
GLI1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
GNRHR	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
GPX2	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
GRK1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
GRK3	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
GSK3A	Affinity Capture-Western, Reconstituted Complex	physical	14563837, (Europe PMC)	NA	BioGRID
GSK3B	Affinity Capture-Western, Split renilla luciferase complementation, Synthetic Lethality, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	association, genetic, physical, physical association	14563837, 19131971, 20713710, 21150319, 25495526, (Europe PMC)	0.37, 0.60	BioGRID, IntAct, MINT
GTF2F1	Reconstituted Complex	physical	8755740, (Europe PMC)	NA	BioGRID
GTF2H4	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
GTF2I	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, tandem affinity purification	association, physical	17314511, 8377829, (Europe PMC)	0.35	BioGRID, IntAct
GTF3C1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
GTF3C2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
GTF3C3	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
GTF3C4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
HADHA	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
HADHB	Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification	association, physical	17314511, 21150319, 26496610, (Europe PMC)	0.64	BioGRID, IntAct
HASPIN	Affinity Capture-MS, Dosage Lethality	genetic, physical	17314511, 22623531, (Europe PMC)	NA	BioGRID
HAUS7	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
HBP1	Affinity Capture-Western, Two-hybrid	physical	20008325, (Europe PMC)	NA	BioGRID
HCK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
HDAC1	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	association, physical	17314511, 18003922, 18271930, 22286234, 24951594, 26496610, (Europe PMC)	0.69	BioGRID, IntAct
HDAC2	Affinity Capture-MS, Affinity Capture-Western, display technology, tandem affinity purification	association, physical, physical association	17314511, 20195357, 22286234, (Europe PMC)	0.56	BioGRID, IntAct
HDAC3	Affinity Capture-Western, anti bait coimmunoprecipitation, chromatin immunoprecipitation assay	association, physical	18483244, 22002311, 23079660, (Europe PMC)	0.46	BioGRID, IntAct
HEATR1	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
HECTD3	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
HELLS	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
HELZ	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
HIF1A	Affinity Capture-Western	physical	15071503, (Europe PMC)	NA	BioGRID
HIGD1A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HIST1H2BL	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HNRNPA0	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HNRNPC	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17353931, 21150319, (Europe PMC)	0.56	BioGRID, IntAct
HNRNPD	Protein-RNA	physical	23603392, (Europe PMC)	NA	BioGRID
HNRNPF	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HNRNPK	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HNRNPU	Affinity Capture-Western	physical	19578763, (Europe PMC)	NA	BioGRID
HPS1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
HSD17B4	Dosage Lethality, tandem affinity purification	association, genetic	21150319, 22623531, (Europe PMC)	0.35	BioGRID, IntAct
HSP90AA1	Affinity Capture-Western	physical	12644583, (Europe PMC)	NA	BioGRID
HSPA1A	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
HSPB1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
HSPD1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HSPH1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HUWE1	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, tandem affinity purification	association, physical	16269333, 17314511, 18488021, 26279298, (Europe PMC)	0.35	BioGRID, IntAct
IDH3A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IDH3B	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IDH3G	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IGF2BP1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IGF2BP2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
IGF2BP3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
IGF2R	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
IKBKG	Affinity Capture-Western, anti tag coimmunoprecipitation, fluorescence microscopy	colocalization, physical, physical association	20970423, (Europe PMC)	0.46	BioGRID, IntAct, MINT
ILVBL	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ING4	Protein-RNA	physical	23603392, (Europe PMC)	NA	BioGRID
IPO13	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IPO4	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
IPO7	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IPO9	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
IQGAP2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
IQGAP3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IRAK1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IRS2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
IRS4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ITGB5	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
JUN	Affinity Capture-Western, tandem affinity purification	association, physical	20232342, 21150319, (Europe PMC)	0.35	BioGRID, IntAct
KAT2A	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	10611234, 12660246, 16287840, 17967894, 20691906, (Europe PMC)	NA	BioGRID
KAT2B	Biochemical Activity	physical	15572685, (Europe PMC)	NA	BioGRID
KAT5	Affinity Capture-Western, Reconstituted Complex	physical	12776177, 18003922, 20946988, (Europe PMC)	NA	BioGRID
KCTD2	Affinity Capture-Western	physical	28060381, (Europe PMC)	NA	BioGRID
KDM1A	Two-hybrid, two hybrid	physical, physical association	23455924, (Europe PMC)	0.37	BioGRID, IntAct, MINT
KDM5B	Affinity Capture-Western	physical	22371483, (Europe PMC)	NA	BioGRID
KIDINS220	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
KIF18A	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
KNDC1	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
KPNA2	Affinity Capture-MS, Two-hybrid, tandem affinity purification, two hybrid array	association, physical, physical association	17314511, 21988832, (Europe PMC)	0.55	BioGRID, IntAct
KPNA4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
KPNB1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
LATS1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
LDOC1	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
LGALS1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
LIMK2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
LMNA	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
LMTK3	Synthetic Lethality	genetic	25495526, (Europe PMC)	NA	BioGRID
LONP1	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
LRPPRC	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, 21150319, (Europe PMC)	0.67	BioGRID, IntAct
LRRC59	Affinity Capture-MS	physical	20848231, (Europe PMC)	NA	BioGRID
MAP2K1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
MAP2K3	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MAP2K7	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MAP3K13	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MAP3K20	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
MAPK1	Reconstituted Complex	physical	15210690, 7957875, (Europe PMC)	NA	BioGRID
MAPK3	Reconstituted Complex	physical	15210690, (Europe PMC)	NA	BioGRID
MAPK8	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	10551811, (Europe PMC)	NA	BioGRID
MARS	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
MATK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MAX	Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure, Co-fractionation, FRET, Reconstituted Complex, Two-hybrid	physical	10229200, 10319872, 10465786, 10593926, 10611234, 10918583, 12391307, 12553908, 12584560, 12660246, 12821782, 12824180, 14749374, 15572685, 16140957, 16287840, 16352593, 16596619, 16705173, 17289033, 17314511, 17353931, 17418410, 17471507, 17643117, 17700062, 18003922, 19578763, 19623651, 2006410, 20382893, 20936779, 20946988, 21150319, 21988832, 23816886, 25522242, 25609649, 26496610, 8224841, 9184233, 9528857, 9680483, 9708738, (Europe PMC)	NA	BioGRID
MCAT	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
MCL1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MCM7	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.73	BioGRID, IntAct
MCU	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
MED1	Reconstituted Complex	physical	17967894, (Europe PMC)	NA	BioGRID
MED16	Reconstituted Complex	physical	17967894, (Europe PMC)	NA	BioGRID
MEN1	Affinity Capture-Western, Reconstituted Complex	physical	19818711, (Europe PMC)	NA	BioGRID
METTL13	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
METTL3	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
MICALL2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
MIPEP	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
MKLN1	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
MLH1	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	12584560, (Europe PMC)	NA	BioGRID
MLH3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
MMS19	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
MNT	Affinity Capture-Western	physical	18271930, (Europe PMC)	NA	BioGRID
MOGS	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MRPL53	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
MRPL58	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MRPS22	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MRPS34	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MSH2	Affinity Capture-MS, Affinity Capture-Western, tandem affinity purification	association, physical	12584560, 17314511, (Europe PMC)	0.35	BioGRID, IntAct
MSH3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MSH6	Affinity Capture-MS	physical	17314511, 17353931, (Europe PMC)	NA	BioGRID
MYBBP1A	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
MYC	Affinity Capture-MS, tandem affinity purification	association, physical	20848231, 21150319, 25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
MYCBP	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	12223483, 9797456, (Europe PMC)	0.37	BioGRID, IntAct
MYCBP2	Affinity Capture-Western, Far Western	physical	26517351, 9689053, (Europe PMC)	NA	BioGRID
MYCN	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
MYLK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MYLK3	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MYO1B	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
MYO3B	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MYO5C	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MYO9A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MYO9B	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MZT2B	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
NABP2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
NCBP2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
NCL	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NCOR1	Synthetic Lethality, tandem affinity purification	association, genetic	21150319, 22157079, (Europe PMC)	0.35	BioGRID, IntAct
NDRG1	Affinity Capture-Western	physical	28456659, (Europe PMC)	NA	BioGRID
NDUFA5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NDUFA8	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NDUFAF3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
NDUFB10	Synthetic Lethality	genetic	22157079, (Europe PMC)	NA	BioGRID
NDUFS1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NDUFS2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
NDUFS3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NECAB3	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
NEIL1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
NEK11	Two-hybrid	physical	21988832, (Europe PMC)	NA	BioGRID
NEK2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
NEK9	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NFE2L2	Affinity Capture-Western	physical	20232342, 22942279, (Europe PMC)	NA	BioGRID
NFYB	Affinity Capture-Western, Reconstituted Complex	physical	11282029, (Europe PMC)	NA	BioGRID
NFYC	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	10446203, (Europe PMC)	NA	BioGRID
NLRX1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
NMI	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, beta galactosidase complementation	physical, physical association	10597290, 11916966, (Europe PMC)	0.37	BioGRID, IntAct
NONO	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
NOP56	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
NOTCH3	Reconstituted Complex	physical	25356737, (Europe PMC)	NA	BioGRID
NQO2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
NR1H3	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
NRXN3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
NTRK1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
NUCB1	Two-hybrid, two hybrid	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
NUP133	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
NUP153	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NUP205	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
NUP93	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17353931, 21150319, (Europe PMC)	0.56	BioGRID, IntAct
OAT	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
OPA1	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17353931, 21150319, (Europe PMC)	0.56	BioGRID, IntAct
P3H1	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
P4HA1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PACSIN1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
PAK2	Affinity Capture-Western, Biochemical Activity	physical	14749374, 16081735, (Europe PMC)	NA	BioGRID
PAK6	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PARP10	Affinity Capture-Western, Co-localization, Reconstituted Complex	physical	15674325, 22992334, (Europe PMC)	NA	BioGRID
PBK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PCBD1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PCBP1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PDCD6	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
PDK1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PDLIM7	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
PDS5A	Affinity Capture-MS	physical	17353931, (Europe PMC)	NA	BioGRID
PDZD2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
PELO	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PES1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PFDN5	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation	association, physical	11567024, 11585818, 11844794, 17728244, 22844532, 9792694, (Europe PMC)	0.35	BioGRID, IntAct
PHKG2	Synthetic Lethality	genetic	25495526, (Europe PMC)	NA	BioGRID
PHLDB2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
PI4KB	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PIAS2	Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical, physical association	17418410, 17471507, (Europe PMC)	0.50	BioGRID, IntAct
PIM1	Affinity Capture-Western	physical	17643117, (Europe PMC)	NA	BioGRID
PIN1	Affinity Capture-Western, anti bait coimmunoprecipitation, isothermal titration calorimetry, nuclear magnetic resonance, surface plasmon resonance	association, direct interaction, physical	15048125, 19131971, 26655473, (Europe PMC)	0.71	BioGRID, IntAct, MINT
PKN1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PKP1	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
PLAU	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
PLIN3	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
PLK1	Affinity Capture-MS, Biochemical Activity, tandem affinity purification	association, physical	17314511, 27773673, (Europe PMC)	0.35	BioGRID, IntAct
PLOD3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PML	Affinity Capture-Western, Reconstituted Complex, tandem affinity purification	association, physical	15735755, 17146439, 21150319, (Europe PMC)	0.35	BioGRID, IntAct
PNO1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
POLA1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
POLD1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
POLE	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
POLH	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
POLR2A	Affinity Capture-MS, chromatin immunoprecipitation assay, tandem affinity purification	association, physical	17314511, 23079660, (Europe PMC)	0.53	BioGRID, IntAct
POLR2B	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
POLR2E	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
POLR2I	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PPP1CA	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PPP2CA	Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association, physical	17632056, 19131971, 25438055, (Europe PMC)	0.46	BioGRID, IntAct, MINT
PPP2R5A	Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical	19131971, (Europe PMC)	0.35	BioGRID, IntAct, MINT
PPP6C	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PPT1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PRC1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PRDX1	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
PRKCD	Synthetic Lethality	genetic	25495526, (Europe PMC)	NA	BioGRID
PRKDC	Affinity Capture-MS, Synthetic Lethality, tandem affinity purification	association, genetic, physical	17314511, 25495526, (Europe PMC)	0.35	BioGRID, IntAct
PRPF6	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, 21150319, (Europe PMC)	0.67	BioGRID, IntAct
PRPF8	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
PSKH2	Synthetic Lethality	genetic	25495526, (Europe PMC)	NA	BioGRID
PSMA1	Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification	association, physical	17314511, 26496610, (Europe PMC)	0.53	BioGRID, IntAct
PSMA2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMA3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
PSMA4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMA5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMA7	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMB1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMB3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMB4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMB5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMC2	Affinity Capture-MS, Dosage Lethality, tandem affinity purification	association, genetic, physical	17314511, 22623531, (Europe PMC)	0.35	BioGRID, IntAct
PSMC3	Affinity Capture-MS, Two-hybrid, tandem affinity purification, two hybrid	association, physical, physical association	17314511, 21988832, (Europe PMC)	0.55	BioGRID, IntAct
PSMC4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMC5	Affinity Capture-Western	physical	12963825, (Europe PMC)	NA	BioGRID
PSMC6	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMD2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
PSMD3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSME4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PTGES2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PTP4A2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PTPN14	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
PTPN9	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
QPCTL	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RAB11FIP5	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RAD21	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
RAF1	Affinity Capture-MS, Reconstituted Complex, tandem affinity purification	association, physical	17314511, 9315742, (Europe PMC)	0.35	BioGRID, IntAct
RANBP2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RARS	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RASGRF1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
RASSF7	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
RB1	Two-hybrid	physical	7838535, (Europe PMC)	NA	BioGRID
RBL1	Affinity Capture-Western	physical	8076603, (Europe PMC)	NA	BioGRID
RBM15	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
RBMS2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RBPJ	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RCN1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RCOR3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RELA	Affinity Capture-Western	physical	12027803, 15616592, (Europe PMC)	NA	BioGRID
REV1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
RFC2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RFC3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RFC4	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17353931, 21150319, (Europe PMC)	0.56	BioGRID, IntAct
RFC5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RHOBTB1	Synthetic Lethality	genetic	22157079, (Europe PMC)	NA	BioGRID
RIF1	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
RIMS2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RIN3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RIOX1	Affinity Capture-Western	physical	17308053, (Europe PMC)	NA	BioGRID
RNF115	Affinity Capture-Western, Co-localization, Reconstituted Complex	physical	22844532, (Europe PMC)	NA	BioGRID
RNF130	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
RNF4	Reconstituted Complex	physical	27653698, (Europe PMC)	NA	BioGRID
RNGTT	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RNH1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ROBO2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RPL11	Affinity Capture-Western, anti tag coimmunoprecipitation	physical, physical association	17599065, (Europe PMC)	0.40	BioGRID, IntAct, MINT
RPL13	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RPN1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RPN2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RPP30	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
RPS27L	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
RUNX1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RUVBL1	Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, tandem affinity purification	association, physical	11509179, 11839798, 17314511, (Europe PMC)	0.35	BioGRID, IntAct
RUVBL2	Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, tandem affinity purification	association, physical	11839798, 12660246, 17314511, 20509972, (Europe PMC)	0.35	BioGRID, IntAct
SAE1	Synthetic Lethality	genetic	22157079, (Europe PMC)	NA	BioGRID
SAP130	Reconstituted Complex	physical	12660246, (Europe PMC)	NA	BioGRID
SARS	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SCO2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SCYL1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
SDC4	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
SDF4	Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification	association, physical	21150319, 26496610, (Europe PMC)	0.53	BioGRID, IntAct
SDK1	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
SEC31B	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SENP2	Biochemical Activity	physical	25895136, (Europe PMC)	NA	BioGRID
SERPINH1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SF3B1	Two-hybrid, two hybrid pooling approach	physical, physical association	20936779, (Europe PMC)	0.37	BioGRID, IntAct
SH3BP4	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SH3KBP1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
SHOC2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SIRT1	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, deacetylase assay	direct interaction, physical, physical association	21807113, 22190494, (Europe PMC)	0.60	BioGRID, IntAct
SKP1	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, tandem affinity purification, two hybrid array	association, physical, physical association	12963825, 17314511, 21988832, (Europe PMC)	0.55	BioGRID, IntAct
SKP2	Affinity Capture-Western, PCA, Reconstituted Complex, anti bait coimmunoprecipitation	physical, physical association	12769844, 12963825, 17157259, 23277542, 24259667, 26038816, (Europe PMC)	0.40	BioGRID, IntAct
SLC1A4	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
SLC25A1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SLC25A11	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SLC25A12	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SLC25A13	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SLC25A26	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
SLC25A3	Affinity Capture-MS	physical	20848231, (Europe PMC)	NA	BioGRID
SLC39A10	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SLIT2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SMAD2	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	11804592, (Europe PMC)	NA	BioGRID
SMAD3	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	11804592, (Europe PMC)	NA	BioGRID
SMAD7	Affinity Capture-Western	physical	24259667, (Europe PMC)	NA	BioGRID
SMARCA2	Reconstituted Complex	physical	14559996, (Europe PMC)	NA	BioGRID
SMARCA4	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation	physical, physical association	11839798, 14559996, 17353931, (Europe PMC)	0.40	BioGRID, IntAct
SMARCA5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
SMARCB1	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	10319872, 14559996, (Europe PMC)	NA	BioGRID
SMARCC1	Affinity Capture-MS, Reconstituted Complex, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	14559996, 17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
SMC2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
SMC4	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, 21150319, (Europe PMC)	0.67	BioGRID, IntAct
SMTN	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SNIP1	Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, two hybrid	physical, physical association	17157259, (Europe PMC)	0.63	BioGRID, IntAct
SNRNP200	Affinity Capture-MS, Dosage Lethality, anti bait coimmunoprecipitation, tandem affinity purification	association, genetic, physical, physical association	17314511, 17353931, 22623531, (Europe PMC)	0.56	BioGRID, IntAct
SNRNP70	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
SNRPC	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
SNW1	Affinity Capture-Western	physical	19818711, (Europe PMC)	NA	BioGRID
SP1	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation	association, physical, physical association	11274368, 15780936, 17418410, 18003922, (Europe PMC)	0.50	BioGRID, IntAct
SPEG	Affinity Capture-MS, Dosage Lethality, tandem affinity purification	association, genetic, physical	21150319, 22623531, (Europe PMC)	0.35	BioGRID, IntAct
SPTLC1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SQOR	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
SQSTM1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SRP9	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SSBP1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SSR1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SSR4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
STUB1	Affinity Capture-Western, Reconstituted Complex	physical	22543587, 28128329, (Europe PMC)	NA	BioGRID
SUCLG1	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
SULF2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
SULT1A2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
SUPT3H	Affinity Capture-Western, Reconstituted Complex	physical	12660246, 17967894, (Europe PMC)	NA	BioGRID
SUV39H1	Dosage Lethality, tandem affinity purification	association, genetic	22623531, 27705803, (Europe PMC)	0.35	BioGRID, IntAct
TADA2A	Reconstituted Complex	physical	12660246, (Europe PMC)	NA	BioGRID
TAF1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
TAF12	Reconstituted Complex	physical	12660246, (Europe PMC)	NA	BioGRID
TAF9	Affinity Capture-Western, Reconstituted Complex	physical	12660246, (Europe PMC)	NA	BioGRID
TARSL2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
TBP	Reconstituted Complex	physical	8755740, (Europe PMC)	NA	BioGRID
TCF12	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TCP1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TDG	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, 26496610, (Europe PMC)	0.35	BioGRID, IntAct
TF	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TFAM	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TFAP2A	Affinity Capture-Western, Reconstituted Complex	physical	7729426, (Europe PMC)	NA	BioGRID
TFAP2C	Affinity Capture-Western, Co-localization, Phenotypic Enhancement	genetic, physical	22371483, (Europe PMC)	NA	BioGRID
TIAM1	Affinity Capture-Western, Reconstituted Complex	physical	12446731, (Europe PMC)	NA	BioGRID
TIE1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
TKT	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TMEM161A	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
TMPO	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TONSL	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
TOP1	Affinity Capture-MS, display technology, tandem affinity purification	association, physical, physical association	17314511, 20195357, (Europe PMC)	0.56	BioGRID, IntAct
TOP2A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TP53	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TP73	Affinity Capture-Western, Reconstituted Complex	physical	11844794, 12080043, (Europe PMC)	NA	BioGRID
TRIB1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
TRIM21	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TRIM25	Affinity Capture-RNA	physical	29117863, (Europe PMC)	NA	BioGRID
TRIM28	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
TRIM6	Affinity Capture-Western, Two-hybrid	physical	22328504, (Europe PMC)	NA	BioGRID
TRIO	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
TRIP12	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down	association, direct interaction, physical, physical association	20208519, (Europe PMC)	0.63	BioGRID, IntAct
TRIP13	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
TRMT1L	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TRPC4AP	Affinity Capture-Western	physical	20551172, 26038816, (Europe PMC)	NA	BioGRID
TRRAP	Affinity Capture-MS, Affinity Capture-Western, Co-localization, Dosage Lethality, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, tandem affinity purification	association, genetic, physical, physical association	10611234, 11511539, 11839798, 12660246, 16705173, 17314511, 17353931, 19818711, 20946988, 21150319, 22623531, 9708738, (Europe PMC)	0.79	BioGRID, IntAct
TSN	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TTC27	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TTC5	Affinity Capture-Western	physical	23559008, (Europe PMC)	NA	BioGRID
TUBA1A	Affinity Capture-Western	physical	20691906, (Europe PMC)	NA	BioGRID
TUBA4A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
TUBB	Affinity Capture-Western	physical	20691906, (Europe PMC)	NA	BioGRID
TUBG1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TUBGCP2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TUT4	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
TXK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
TXN	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
U2SURP	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
UBA2	Synthetic Lethality	genetic	22157079, (Europe PMC)	NA	BioGRID
UBE2I	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
UBE2L3	Affinity Capture-Western	physical	11431533, (Europe PMC)	NA	BioGRID
UBE2O	Synthetic Lethality	genetic	22157079, (Europe PMC)	NA	BioGRID
UBE3C	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
UBR2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
USP2	Biochemical Activity	physical	25895136, (Europe PMC)	NA	BioGRID
USP22	Affinity Capture-Western, Co-localization, Reconstituted Complex	physical	18206973, 28160502, (Europe PMC)	NA	BioGRID
USP28	Affinity Capture-Western, Biochemical Activity	physical	17558397, 17873522, 23389829, 25716680, (Europe PMC)	NA	BioGRID
USP33	Synthetic Lethality	genetic	22157079, (Europe PMC)	NA	BioGRID
USP36	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	25775507, (Europe PMC)	NA	BioGRID
USP37	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	25284584, (Europe PMC)	NA	BioGRID
USP7	Affinity Capture-Western, Reconstituted Complex	physical	27618649, (Europe PMC)	NA	BioGRID
VDR	Affinity Capture-Western	physical	23112173, (Europe PMC)	NA	BioGRID
VHL	Affinity Capture-Western	physical	22286234, (Europe PMC)	NA	BioGRID
WDR5	Affinity Capture-Western, anti bait coimmunoprecipitation	physical, physical association	17353931, 27320920, (Europe PMC)	0.40	BioGRID, IntAct
WDR77	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
WEE1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
WEE2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
WNK1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
WWP2	Affinity Capture-Western	physical	26894970, (Europe PMC)	NA	BioGRID
XDH	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
XPO1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 26673895, (Europe PMC)	0.35	BioGRID, IntAct
XPO5	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
XPOT	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
XRCC5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
XRCC6	Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.46	BioGRID, IntAct
XRN1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
XYLT1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
YBX1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
YEATS4	Affinity Capture-MS, Reconstituted Complex	physical	22068108, 26186194, 28514442, (Europe PMC)	NA	BioGRID
YES1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
YWHAB	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
YWHAE	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
YWHAQ	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
YY1	Reconstituted Complex, Two-hybrid	physical	8266081, (Europe PMC)	NA	BioGRID
ZBTB17	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down	direct interaction, physical, physical association	11283613, 16352593, 17418410, 18923429, 19786833, 20426839, 26766587, 9312026, (Europe PMC)	0.78	BioGRID, IntAct, MINT
ZFYVE21	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
ZNF121	Affinity Capture-MS, tandem affinity purification, two hybrid	association, physical, physical association	17314511, (Europe PMC)	0.48	BioGRID, IntAct
ZNF281	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct

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Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
ABCA2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
ABCA9	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ABCB1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ABCB7	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
ABRA	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ACACA	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
ACACB	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ACOT8	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ACTC1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
ACTG1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
ACTL6A	Affinity Capture-MS, Affinity Capture-Western, Co-purification, tandem affinity purification	association, physical	11839798, 17314511, 25609649, (Europe PMC)	0.53	BioGRID, IntAct, MINT
ACTL8	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
ADAMTS20	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ADAR	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
ADIPOR1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ADNP	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
AFAP1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
AGK	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
AGPAT1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
AHNAK	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
AHNAK2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
AIFM2	Dosage Lethality, tandem affinity purification	association, genetic	21150319, 22623531, (Europe PMC)	0.35	BioGRID, IntAct
AJAP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
AKAP8	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
AKAP8L	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ALDH18A1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ALDH1B1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ALPK3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
AMBRA1	Affinity Capture-Western, anti bait coimmunoprecipitation	physical, physical association	25438055, (Europe PMC)	0.40	BioGRID, IntAct
AMOTL2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ANLN	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ANXA2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
AP2A1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
AP3D1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
AP4B1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ARCN1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
ARF1	anti bait coimmunoprecipitation	physical association	17289033, (Europe PMC)	0.40	IntAct, MINT
ARF4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ARFGAP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ARG1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ARHGEF2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
ARID4B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ARID5B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ARL1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ARMC6	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
ARSB	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ASPM	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ASS1	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
ATAD3B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ATM	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ATP1A1	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
ATP2A2	anti bait coimmunoprecipitation, tandem affinity purification	association, physical association	17314511, 17353931, (Europe PMC)	0.56	IntAct
ATP5F1C	tandem affinity purification	association	17314511, 21150319, (Europe PMC)	0.53	IntAct
ATP5J2	tandem affinity purification	association	17314511, 21150319, (Europe PMC)	0.53	IntAct
ATP5O	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ATP6V1D	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ATP6V1H	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
ATXN10	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
AXIN1	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association, direct interaction, physical, physical association	19131971, (Europe PMC)	0.62	BioGRID, IntAct, MINT
B4GALT7	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
BAHCC1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
BCO1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
BCR	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
BICRA	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
BIN1	Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, nuclear magnetic resonance, two hybrid	direct interaction, physical, physical association	10380878, 15992821, (Europe PMC)	0.51, 0.59	BioGRID, IntAct, MINT
BPTF	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
BRD3	Reconstituted Complex, display technology, tandem affinity purification	physical, physical association	20195357, (Europe PMC)	0.52	BioGRID, IntAct
BRPF1	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
BRWD1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
BTAF1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
BUB1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
C1QBP	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
C2orf16	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
C4A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CACNA1G	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CALCOCO2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CALD1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CAMK2D	Affinity Capture-MS, Dosage Lethality, tandem affinity purification	association, genetic, physical	21150319, 22623531, (Europe PMC)	0.35	BioGRID, IntAct
CAVIN1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CAVIN3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CBFB	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
CCAR2	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, cosedimentation through density gradient, tandem affinity purification, two hybrid	association, physical, physical association	17314511, 17353931, 22190494, (Europe PMC)	0.75	BioGRID, IntAct
CCM2L	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CCT2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CCT3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CCT4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CCT5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CCT6A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CCT8	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CDC26	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CDC42EP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CDCA7L	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation	physical, physical association	15994933, 16829576, (Europe PMC)	0.40	BioGRID, IntAct
CDK1	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
CDK4	Biochemical Activity, Two-hybrid, protein kinase assay, two hybrid array	phosphorylation reaction, physical, physical association	21988832, 22094256, (Europe PMC)	0.59	BioGRID, IntAct
CDK5RAP2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CDK6	Biochemical Activity, protein kinase assay	phosphorylation reaction, physical	22094256, (Europe PMC)	0.44	BioGRID, IntAct
CDV3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CDYL	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CEBPZ	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
CENPF	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
CENPV	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CEP170	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CEP55	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CEP57	Reconstituted Complex, display technology, tandem affinity purification	physical, physical association	20195357, (Europe PMC)	0.52	BioGRID, IntAct
CEPT1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CFL1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CHAF1B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CHCHD3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
CHD4	Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, (Europe PMC)	0.50	BioGRID, IntAct
CHD5	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
CHD9	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
CHTF18	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CHUK	Affinity Capture-Western, anti bait coimmunoprecipitation, confocal microscopy	colocalization, physical, physical association	21575199, (Europe PMC)	0.46	BioGRID, IntAct
CIP2A	anti tag coimmunoprecipitation, pull down	direct interaction, physical association	17632056, (Europe PMC)	0.54	IntAct
CKAP4	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
CLEC11A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CLSTN1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CNMD	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CNOT11	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CNOT4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CNTN5	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
COPB2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
COPG1	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
COPG2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CPSF1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
CPSF2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CROCC	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CSE1L	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CSF1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CSMD2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CSPP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CTBP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CTNND1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
CTPS1	anti bait coimmunoprecipitation, tandem affinity purification	association, physical association	17353931, 21150319, (Europe PMC)	0.56	IntAct
CTR9	Affinity Capture-Western, tandem affinity purification	association, physical	21150319, 26687678, (Europe PMC)	0.35	BioGRID, IntAct
CYBA	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CYC1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
CYP2U1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CYR61	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DACT1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DCLK1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
DCTN1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
DDX1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DDX17	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
DDX20	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
DDX24	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17353931, 21150319, (Europe PMC)	0.56	BioGRID, IntAct
DDX3X	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
DDX47	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DDX51	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DDX52	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DENND3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DENND6B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DHX15	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DHX37	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
DHX58	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DIAPH3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
DIMT1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DIP2B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DIRAS2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DNAAF5 {ECO:0000303\|PubMed:25232951,	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
DNAJA2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DNAJA3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DNAJB11	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
DNAJB12	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DNAJB6	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DNM2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
DOCK7	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DPM1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
DSP	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
DUSP15	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DYNC1H1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DYNC1LI1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DYNLRB1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
EBI-1058428	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058461	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058587	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058623	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058683	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058689	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058844	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058847	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058859	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1648030	pull down	association, physical association	17728244, (Europe PMC)	0.50	IntAct
EBI-1648054	pull down	association	17728244, (Europe PMC)	0.35	IntAct
EBI-3962679	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
EBI-4399559	pull down	physical association	18413597, (Europe PMC)	0.40	IntAct
ECSIT	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
ECT2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EEF1G	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
EFNB1	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
EFTUD2	Affinity Capture-MS, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, cosedimentation through density gradient, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.68	BioGRID, IntAct
EHHADH	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
EIF3E	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
EIF3I	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
EIF4A1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
EIF4ENIF1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ELFN1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ELMSAN1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ELP1	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
ENSG00000003402	chromatin immunoprecipitation assay	association	22266862, (Europe PMC)	0.35	IntAct
ENSG00000012048	chromatin immunoprecipitation assay	association	21668996, (Europe PMC)	0.35	IntAct
ENSG00000084774	chromatin immunoprecipitation assay	association	17157259, 24951594, (Europe PMC)	0.53	IntAct
ENSG00000089009	chromatin immunoprecipitation assay	association	23217706, (Europe PMC)	0.35	IntAct
ENSG00000100316	chromatin immunoprecipitation assay	association	23217706, (Europe PMC)	0.35	IntAct
ENSG00000114315	chromatin immunoprecipitation assay	association	24951594, (Europe PMC)	0.35	IntAct
ENSG00000115053	chromatin immunoprecipitation assay	association	24951594, (Europe PMC)	0.35	IntAct
ENSG00000124762	chromatin immunoprecipitation assay	association	15084259, (Europe PMC)	0.35	IntAct
ENSG00000125691	chromatin immunoprecipitation assay	association	23217706, (Europe PMC)	0.35	IntAct
ENSG00000134057	chromatin immunoprecipitation assay	association	17157259, (Europe PMC)	0.35	IntAct
ENSG00000134333	chromatin immunoprecipitation assay	association	24951594, (Europe PMC)	0.35	IntAct
ENSG00000134419	chromatin immunoprecipitation assay	association	23217706, (Europe PMC)	0.35	IntAct
ENSG00000135446	chromatin immunoprecipitation assay	association	24951594, (Europe PMC)	0.35	IntAct
ENSG00000145545	chromatin immunoprecipitation assay	association	24951594, (Europe PMC)	0.35	IntAct
ENSG00000177606	chromatin immunoprecipitation assay	association	22266862, (Europe PMC)	0.35	IntAct
EP300	Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation	physical, physical association	15616592, 16126174, 16287840, 17157259, (Europe PMC)	0.40	BioGRID, IntAct
EP400	Affinity Capture-MS, Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	association, physical, physical association	11509179, 17314511, 18413597, 20946988, 21150319, (Europe PMC)	0.40, 0.67	BioGRID, IntAct
EPC1	Affinity Capture-MS, tandem affinity purification	association, physical	20946988, 21150319, (Europe PMC)	0.35	BioGRID, IntAct
EPPK1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
ERBIN	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ERC1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
ERCC3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ERP44	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ETFA	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ETV3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
ETV6	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
EU154351.1	chromatin immunoprecipitation assay	association	23079660, (Europe PMC)	0.35	IntAct
EU154353.1	chromatin immunoprecipitation assay	association	23079660, (Europe PMC)	0.35	IntAct
EXOC1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EXOC3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EXOC4	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
EXOSC1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
EZH2	chromatin immunoprecipitation assay	association	23079660, (Europe PMC)	0.35	IntAct
FAF2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FAM117B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FAM122B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FANCD2	Affinity Capture-MS, Co-localization, tandem affinity purification	association, physical	17314511, 24658369, (Europe PMC)	0.35	BioGRID, IntAct
FANCI	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
FANCM	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FASTKD1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FASTKD2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
FBL	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
FBXW7	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	association, physical association	17157259, 17314511, 23791182, (Europe PMC)	0.67	IntAct
FBXW8	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid	association, physical, physical association	17314511, (Europe PMC)	0.57	BioGRID, IntAct
FERMT3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FHL2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
FLNA	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
FN1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
FOSL1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
FOSL2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FOXC2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FOXO3	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	physical association	18393360, (Europe PMC)	0.52	IntAct
FOXO6	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
FOXP1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
FOXR1	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, 26186194, 28514442, (Europe PMC)	0.35	BioGRID, IntAct, MINT
FOXR2	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, 26186194, 28514442, (Europe PMC)	0.35	BioGRID, IntAct, MINT
FRMD6	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FRMPD4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FZR1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
GABRR1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
GANAB	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
GCDH	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
GCN1	tandem affinity purification, two hybrid pooling approach	association, physical association	17314511, 20936779, (Europe PMC)	0.55	IntAct
GEMIN4	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
GFPT1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
GIGYF2 {ECO:0000303\|PubMed:12771153,	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
GLUD2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
GNL3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
GPR158	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
GPX2	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
GSK3B	Affinity Capture-Western, Split renilla luciferase complementation, Synthetic Lethality, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	association, genetic, physical, physical association	14563837, 19131971, 20713710, 21150319, 25495526, (Europe PMC)	0.37, 0.60	BioGRID, IntAct, MINT
GTF2I	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, tandem affinity purification	association, physical	17314511, 8377829, (Europe PMC)	0.35	BioGRID, IntAct
GTF3C1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
GTF3C2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
GTF3C3	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
GTF3C4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
H2AFZ	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
H3F3A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HADHA	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
HADHB	Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification	association, physical	17314511, 21150319, 26496610, (Europe PMC)	0.64	BioGRID, IntAct
HASPIN	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
HCFC2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HDAC1	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	association, physical	17314511, 18003922, 18271930, 22286234, 24951594, 26496610, (Europe PMC)	0.69	BioGRID, IntAct
HDAC2	Affinity Capture-MS, Affinity Capture-Western, display technology, tandem affinity purification	association, physical, physical association	17314511, 20195357, 22286234, (Europe PMC)	0.56	BioGRID, IntAct
HDAC3	Affinity Capture-Western, anti bait coimmunoprecipitation, chromatin immunoprecipitation assay	association, physical	18483244, 22002311, 23079660, (Europe PMC)	0.46	BioGRID, IntAct
HEATR1	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
HEATR3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
HELLS	anti bait coimmunoprecipitation, tandem affinity purification	association, physical association	17314511, 17353931, (Europe PMC)	0.56	IntAct
HIGD1A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HIRA	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HIST1H1A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HIST1H2AB	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HIST1H2BL	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HIST1H2BM	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HIST1H4A	chromatin immunoprecipitation assay	association	23079660, (Europe PMC)	0.35	IntAct
HK1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HNRNPA0	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HNRNPC	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17353931, 21150319, (Europe PMC)	0.56	BioGRID, IntAct
HNRNPF	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HNRNPK	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HOXA10	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HOXB5	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HSD17B4	Dosage Lethality, tandem affinity purification	association, genetic	21150319, 22623531, (Europe PMC)	0.35	BioGRID, IntAct
HSPA8	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HSPB1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
HSPD1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HSPH1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HUWE1	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, tandem affinity purification	association, physical	16269333, 17314511, 18488021, 26279298, (Europe PMC)	0.35	BioGRID, IntAct
ICA1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
IDH3A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IDH3B	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IDH3G	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IGF2BP1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IGF2BP2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
IGF2BP3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
IK	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
IKBKG	Affinity Capture-Western, anti tag coimmunoprecipitation, fluorescence microscopy	colocalization, physical, physical association	20970423, (Europe PMC)	0.46	BioGRID, IntAct, MINT
IKZF2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
IL16	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
IL1B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
IL4R	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ILVBL	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IMMT	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
INSM1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
IPO11	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
IPO13	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IPO4	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
IPO7	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IPO9	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
IQCE	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
IQGAP1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
IQGAP2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
IQGAP3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IRAK1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IRS4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ITGAL	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
JUN	Affinity Capture-Western, tandem affinity purification	association, physical	20232342, 21150319, (Europe PMC)	0.35	BioGRID, IntAct
KALRN	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KANK2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KARS	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KCNG3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KDM1A	Two-hybrid, two hybrid	physical, physical association	23455924, (Europe PMC)	0.37	BioGRID, IntAct, MINT
KIAA0319	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KIAA2026	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KIDINS220	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
KIF12	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KIF20B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KIF25	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KLF10	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KLHL5	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
KMT2A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KNDC1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KPNA2	Affinity Capture-MS, Two-hybrid, tandem affinity purification, two hybrid array	association, physical, physical association	17314511, 21988832, (Europe PMC)	0.55	BioGRID, IntAct
KPNA4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
KPNB1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
LAS1L	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
LATS1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
LBR	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
LBX2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
LCN12	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
LDOC1	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
LGALS1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
LGALS7	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
LIMS1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
LMNA	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
LMO7	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
LONP1	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
LOX	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
LRP1B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
LRPPRC	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, 21150319, (Europe PMC)	0.67	BioGRID, IntAct
MAATS1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MAGEB10	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MAGED2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
MAGI1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MAP1A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MAP2K1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
MAP3K1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MAP3K20	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
MAP3K5	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MAP3K7	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MAP7D1	anti bait coimmunoprecipitation, tandem affinity purification	association, physical association	17353931, 21150319, (Europe PMC)	0.56	IntAct
MAPKAP1	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
MARS	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
MAST4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MATN4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MATR3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
MAX	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, nuclear magnetic resonance, proximity ligation assay, tandem affinity purification, two hybrid, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach	association, direct interaction, physical association	12821782, 16352593, 16606833, 17157259, 17314511, 17353931, 17418410, 18620061, 20691906, 20936779, 21150319, 21807113, 21988832, 24951594, 25609649, 26267534, 26496610, 27705803, 9680483, (Europe PMC)	0.35, 0.98	IntAct, MINT
MBD3	anti tag coimmunoprecipitation	association, physical association	24048479, (Europe PMC)	0.50	IntAct
MCAT	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
MCF2L2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MCM3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
MCM4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MCM7	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.73	BioGRID, IntAct
MCTP2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MCU	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
MDN1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
MED12L	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
METTL13	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
METTL3	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
MFGE8	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MFHAS1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MIB1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MICALL2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
MIPEP	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
MKL1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MKLN1	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
MLH3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
MMS19	anti bait coimmunoprecipitation, tandem affinity purification	association, physical association	17314511, 17353931, (Europe PMC)	0.56	IntAct
MOGS	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MRGBP	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MRPL14	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MRPL53	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
MRPS22	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MRPS34	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MSH2	Affinity Capture-MS, Affinity Capture-Western, tandem affinity purification	association, physical	12584560, 17314511, (Europe PMC)	0.35	BioGRID, IntAct
MSH3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MSH6	anti bait coimmunoprecipitation, tandem affinity purification	association, physical association	17314511, 17353931, (Europe PMC)	0.56	IntAct
MTHFD1L	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
MTRF1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MUC3A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MUC5AC	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MYBBP1A	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
MYC	Affinity Capture-MS, tandem affinity purification	association, physical	20848231, 21150319, 25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
MYCBP	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	12223483, 9797456, (Europe PMC)	0.37	BioGRID, IntAct
MYCN	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
MYO18A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MYO1B	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
MYO1D	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MYO5A	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
MYO5C	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MYO9A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MYO9B	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MZT2B	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
NABP2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
NAIP	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NAP1L1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
NAV2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NAV3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NCAPD3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
NCAPG2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
NCBP2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
NCL	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NCOR1	Synthetic Lethality, tandem affinity purification	association, genetic	21150319, 22157079, (Europe PMC)	0.35	BioGRID, IntAct
NCOR2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NDUFA5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NDUFA8	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NDUFAF3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
NDUFS1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NDUFS2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
NDUFS3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NEK11	two hybrid array	physical association	21988832, (Europe PMC)	0.37	IntAct
NEK9	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NFIL3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NLRX1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
NMI	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, beta galactosidase complementation	physical, physical association	10597290, 11916966, (Europe PMC)	0.37	BioGRID, IntAct
NOC2L	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
NOL11	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
NOL9	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
NOMO3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NONO	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
NOP56	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
NPC1L1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NPR1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NPTX2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NRDC	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NRXN3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
NUCB1	Two-hybrid, two hybrid	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
NUP133	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
NUP153	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NUP188	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
NUP205	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
NUP93	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17353931, 21150319, (Europe PMC)	0.56	BioGRID, IntAct
NUP98	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
OAT	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
OBSCN	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
OPA1	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17353931, 21150319, (Europe PMC)	0.56	BioGRID, IntAct
OPHN1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
OTUD4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
P3H1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
P4HA1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PADI2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PALD1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PCBP1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PCBP2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PDCD11	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
PDCD6	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
PDHA2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PDLIM4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PDLIM7	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
PDS5A	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
PDS5B	anti bait coimmunoprecipitation, tandem affinity purification	association, physical association	17353931, 21150319, (Europe PMC)	0.56	IntAct
PDZD2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
PELO	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PFDN2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PFDN5	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation	association, physical	11567024, 11585818, 11844794, 17728244, 22844532, 9792694, (Europe PMC)	0.35	BioGRID, IntAct
PGAP1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
PGD	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PHF20	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PHF6	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PHLDB2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
PIAS2	Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical, physical association	17418410, 17471507, (Europe PMC)	0.50	BioGRID, IntAct
PIN1	Affinity Capture-Western, anti bait coimmunoprecipitation, isothermal titration calorimetry, nuclear magnetic resonance, surface plasmon resonance	association, direct interaction, physical	15048125, 19131971, 26655473, (Europe PMC)	0.71	BioGRID, IntAct, MINT
PITX2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PKM	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PKP1	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
PLA2G4A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PLAU	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
PLEKHH1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PLIN3	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
PLK1	Affinity Capture-MS, Biochemical Activity, tandem affinity purification	association, physical	17314511, 27773673, (Europe PMC)	0.35	BioGRID, IntAct
PLOD2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PLOD3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PML	Affinity Capture-Western, Reconstituted Complex, tandem affinity purification	association, physical	15735755, 17146439, 21150319, (Europe PMC)	0.35	BioGRID, IntAct
PNO1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
POLD1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
POLE	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
POLG	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
POLR2A	Affinity Capture-MS, chromatin immunoprecipitation assay, tandem affinity purification	association, physical	17314511, 23079660, (Europe PMC)	0.53	BioGRID, IntAct
POLR2B	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
POLR3A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
POP4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PPA2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PPIP5K2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PPP1CA	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PPP1R15A	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
PPP1R2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
PPP2CA	Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association, physical	17632056, 19131971, 25438055, (Europe PMC)	0.46	BioGRID, IntAct, MINT
PPP2R3B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PPP2R5A	Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical	19131971, (Europe PMC)	0.35	BioGRID, IntAct, MINT
PPP6C	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PPT1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PRDX1	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
PREX2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PRG4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PRKAR1B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PRKDC	Affinity Capture-MS, Synthetic Lethality, tandem affinity purification	association, genetic, physical	17314511, 25495526, (Europe PMC)	0.35	BioGRID, IntAct
PRPF6	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, 21150319, (Europe PMC)	0.67	BioGRID, IntAct
PRPF8	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
PRR11	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PRRC2A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PSMA1	Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification	association, physical	17314511, 26496610, (Europe PMC)	0.53	BioGRID, IntAct
PSMA2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMA3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
PSMA4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMA5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMA7	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMB1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMB3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMB4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMB5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMC1	tandem affinity purification	association	17314511, 21150319, (Europe PMC)	0.53	IntAct
PSMC2	Affinity Capture-MS, Dosage Lethality, tandem affinity purification	association, genetic, physical	17314511, 22623531, (Europe PMC)	0.35	BioGRID, IntAct
PSMC3	Affinity Capture-MS, Two-hybrid, tandem affinity purification, two hybrid	association, physical, physical association	17314511, 21988832, (Europe PMC)	0.55	BioGRID, IntAct
PSMC4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMC6	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMD2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
PSMD3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMD4	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
PSME4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PTBP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PTGES2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PTPN14	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
QPCTL	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RAB11FIP5	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RAD50	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RAF1	Affinity Capture-MS, Reconstituted Complex, tandem affinity purification	association, physical	17314511, 9315742, (Europe PMC)	0.35	BioGRID, IntAct
RAG1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RALGAPA1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RANBP2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RARS	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RBFA	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RBFOX2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RBM10	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RBM15	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
RBM39	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RBMS2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RBPJ	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RCN1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RCOR3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RFC1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
RFC2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RFC3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RFC4	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17353931, 21150319, (Europe PMC)	0.56	BioGRID, IntAct
RFC5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RFX7	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RIF1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RIMS2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RIN3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RNF130	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RNGTT	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RNH1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ROBO2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RPL11	Affinity Capture-Western, anti tag coimmunoprecipitation	physical, physical association	17599065, (Europe PMC)	0.40	BioGRID, IntAct, MINT
RPL13	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RPL26L1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RPN1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RPN2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RPP30	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
RPRD2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RPS16	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RPS2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RPS21	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RPS27L	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RRM1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RRP1B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RUNX1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RUNX2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RUVBL1	Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, tandem affinity purification	association, physical	11509179, 11839798, 17314511, (Europe PMC)	0.35	BioGRID, IntAct
RUVBL2	Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, tandem affinity purification	association, physical	11839798, 12660246, 17314511, 20509972, (Europe PMC)	0.35	BioGRID, IntAct
SACS	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SAMD9L	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SARS	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SBNO2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SCD	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SCO2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SDF2L1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SDF4	Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification	association, physical	21150319, 26496610, (Europe PMC)	0.53	BioGRID, IntAct
SDHA	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SDK1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SEC11C	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SEC31B	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SEC61A1	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
SERPINH1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SET	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SETX	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SF3B1	Two-hybrid, two hybrid pooling approach	physical, physical association	20936779, (Europe PMC)	0.37	BioGRID, IntAct
SGO2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SH3BP4	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SH3RF1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SHANK2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SHE	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SHOC2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SIN3B	anti bait coimmunoprecipitation, chromatin immunoprecipitation assay, confocal microscopy, proximity ligation assay	association, colocalization, physical association	24951594, (Europe PMC)	0.63	IntAct
SIPA1L3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SIRT1	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, deacetylase assay	direct interaction, physical, physical association	21807113, 22190494, (Europe PMC)	0.60	BioGRID, IntAct
SIRT2	anti tag coimmunoprecipitation	physical association	23217706, (Europe PMC)	0.40	IntAct
SIRT5	anti tag coimmunoprecipitation	physical association	23217706, (Europe PMC)	0.40	IntAct
SIRT6	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	physical association	23217706, (Europe PMC)	0.52	IntAct
SKIV2L	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
SKP1	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, tandem affinity purification, two hybrid array	association, physical, physical association	12963825, 17314511, 21988832, (Europe PMC)	0.55	BioGRID, IntAct
SKP2	Affinity Capture-Western, PCA, Reconstituted Complex, anti bait coimmunoprecipitation	physical, physical association	12769844, 12963825, 17157259, 23277542, 24259667, 26038816, (Europe PMC)	0.40	BioGRID, IntAct
SLC25A1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SLC25A10	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SLC25A11	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SLC25A12	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SLC25A13	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SLC39A10	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SLIT2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SMARCA4	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation	physical, physical association	11839798, 14559996, 17353931, (Europe PMC)	0.40	BioGRID, IntAct
SMARCA5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
SMARCAD1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
SMARCC1	Affinity Capture-MS, Reconstituted Complex, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	14559996, 17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
SMARCC2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
SMC1A	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
SMC2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
SMC3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
SMC4	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, 21150319, (Europe PMC)	0.67	BioGRID, IntAct
SMC6	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SMTN	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SMYD4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SNIP1	Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, two hybrid	physical, physical association	17157259, (Europe PMC)	0.63	BioGRID, IntAct
SNRNP200	Affinity Capture-MS, Dosage Lethality, anti bait coimmunoprecipitation, tandem affinity purification	association, genetic, physical, physical association	17314511, 17353931, 22623531, (Europe PMC)	0.56	BioGRID, IntAct
SNRNP70	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
SNRPD2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SNRPF	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SNX19	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SORBS1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SP1	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation	association, physical, physical association	11274368, 15780936, 17418410, 18003922, (Europe PMC)	0.50	BioGRID, IntAct
SPATA31E1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SPEG	Affinity Capture-MS, Dosage Lethality, tandem affinity purification	association, genetic, physical	21150319, 22623531, (Europe PMC)	0.35	BioGRID, IntAct
SPTLC1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SQOR	tandem affinity purification	association	17314511, 21150319, (Europe PMC)	0.53	IntAct
SQSTM1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SRP14	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
SRP9	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SSBP1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SSR1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SSR4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ST6GALNAC6	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
STAG2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
SUCLG1	tandem affinity purification	association	17314511, 21150319, (Europe PMC)	0.53	IntAct
SUCLG2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SUV39H1	Dosage Lethality, tandem affinity purification	association, genetic	22623531, 27705803, (Europe PMC)	0.35	BioGRID, IntAct
SUZ12	anti bait coimmunoprecipitation, chromatin immunoprecipitation assay	association	23079660, (Europe PMC)	0.46	IntAct
SYNE1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TAF2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TARSL2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
TBL2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TCF12	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TCP1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TDG	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, 26496610, (Europe PMC)	0.35	BioGRID, IntAct
TENM2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TEX2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TF	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TFAM	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TKT	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TMEM131L	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TMEM161A	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
TMEM33	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
TMPO	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TMPRSS11A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TNFRSF18	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TNPO1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TNPO3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
TNR	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TNS2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TONSL	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
TOP1	Affinity Capture-MS, display technology, tandem affinity purification	association, physical, physical association	17314511, 20195357, (Europe PMC)	0.56	BioGRID, IntAct
TOP2A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TP53	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TP53BP1	display technology, proximity-dependent biotin identification	association, physical association	20195357, 29656893, (Europe PMC)	0.56	IntAct
TPH1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TPP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TRABD2A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TRAK1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TRAP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TRIM21	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TRIM28	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
TRIO	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
TRIP12	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down	association, direct interaction, physical, physical association	20208519, (Europe PMC)	0.63	BioGRID, IntAct
TRMT1L	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TRPM1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TRRAP	Affinity Capture-MS, Affinity Capture-Western, Co-localization, Dosage Lethality, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, tandem affinity purification	association, genetic, physical, physical association	10611234, 11511539, 11839798, 12660246, 16705173, 17314511, 17353931, 19818711, 20946988, 21150319, 22623531, 9708738, (Europe PMC)	0.79	BioGRID, IntAct
TSN	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TTC27	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TTN	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TUBA4A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
TUBB3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TUBB6	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TUBG1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TUBGCP2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TUBGCP4	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
TUFM	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TXN	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
U2SURP	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
UBA1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
UBC	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	association, physical association	16996503, 19131971, 21150319, (Europe PMC)	0.69	IntAct, MINT
UBE3C	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
UBR2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
UBTF	display technology, tandem affinity purification	association, physical association	20195357, 21150319, (Europe PMC)	0.56	IntAct
UNC45A	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
UQCRFS1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
USP10	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
USP36	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
USP48	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
USP9X	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
UST	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
UTP15	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
WDFY3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
WDR5	Affinity Capture-Western, anti bait coimmunoprecipitation	physical, physical association	17353931, 27320920, (Europe PMC)	0.40	BioGRID, IntAct
WDR77	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
WIPF1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
XDH	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
XKRX	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
XPO1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 26673895, (Europe PMC)	0.35	BioGRID, IntAct
XPO5	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
XPO7	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
XPOT	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
XRCC5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
XRCC6	Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.46	BioGRID, IntAct
XRN1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
XYLT1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
YAF2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
YBX1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
YWHAB	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
YWHAE	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
YWHAQ	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ZBTB17	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down	direct interaction, physical, physical association	11283613, 16352593, 17418410, 18923429, 19786833, 20426839, 26766587, 9312026, (Europe PMC)	0.78	BioGRID, IntAct, MINT
ZBTB18	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZC3H18	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZC3H7B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZCCHC11	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZFHX3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZFYVE21	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
ZNF106	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZNF121	Affinity Capture-MS, tandem affinity purification, two hybrid	association, physical, physical association	17314511, (Europe PMC)	0.48	BioGRID, IntAct
ZNF281	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ZNF354B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZNF541	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZNF586	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZNF703	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZNF740	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZZEF1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct

Visualize Download

Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
ARF1	anti bait coimmunoprecipitation	physical association	17289033, (Europe PMC)	0.40	IntAct, MINT
AXIN1	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association, direct interaction, physical, physical association	19131971, (Europe PMC)	0.62	BioGRID, IntAct, MINT
BIN1	Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, nuclear magnetic resonance, two hybrid	direct interaction, physical, physical association	10380878, 15992821, (Europe PMC)	0.51, 0.59	BioGRID, IntAct, MINT
FOXO6	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
FOXR1	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, 26186194, 28514442, (Europe PMC)	0.35	BioGRID, IntAct, MINT
FOXR2	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, 26186194, 28514442, (Europe PMC)	0.35	BioGRID, IntAct, MINT
GSK3B	Affinity Capture-Western, Split renilla luciferase complementation, Synthetic Lethality, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	association, genetic, physical, physical association	14563837, 19131971, 20713710, 21150319, 25495526, (Europe PMC)	0.37, 0.60	BioGRID, IntAct, MINT
IKBKG	Affinity Capture-Western, anti tag coimmunoprecipitation, fluorescence microscopy	colocalization, physical, physical association	20970423, (Europe PMC)	0.46	BioGRID, IntAct, MINT
KDM1A	Two-hybrid, two hybrid	physical, physical association	23455924, (Europe PMC)	0.37	BioGRID, IntAct, MINT
MAX	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, nuclear magnetic resonance, proximity ligation assay, tandem affinity purification, two hybrid, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach	association, direct interaction, physical association	12821782, 16352593, 16606833, 17157259, 17314511, 17353931, 17418410, 18620061, 20691906, 20936779, 21150319, 21807113, 21988832, 24951594, 25609649, 26267534, 26496610, 27705803, 9680483, (Europe PMC)	0.35, 0.98	IntAct, MINT
MYC	Affinity Capture-MS, tandem affinity purification	association, physical	20848231, 21150319, 25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
MYCN	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
PIN1	Affinity Capture-Western, anti bait coimmunoprecipitation, isothermal titration calorimetry, nuclear magnetic resonance, surface plasmon resonance	association, direct interaction, physical	15048125, 19131971, 26655473, (Europe PMC)	0.71	BioGRID, IntAct, MINT
PKP1	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
PPP2CA	Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association, physical	17632056, 19131971, 25438055, (Europe PMC)	0.46	BioGRID, IntAct, MINT
PPP2R5A	Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical	19131971, (Europe PMC)	0.35	BioGRID, IntAct, MINT
RPL11	Affinity Capture-Western, anti tag coimmunoprecipitation	physical, physical association	17599065, (Europe PMC)	0.40	BioGRID, IntAct, MINT
UBC	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	association, physical association	16996503, 19131971, 21150319, (Europe PMC)	0.69	IntAct, MINT
ZBTB17	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down	direct interaction, physical, physical association	11283613, 16352593, 17418410, 18923429, 19786833, 20426839, 26766587, 9312026, (Europe PMC)	0.78	BioGRID, IntAct, MINT

Visualize Download

Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
ABCA2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
ABCA9	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ABCB1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ABCB7	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
ABRA	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ACACA	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
ACACB	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ACOT8	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ACTB	Co-purification	physical	11839798, (Europe PMC)	NA	BioGRID
ACTC1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
ACTG1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
ACTL6A	Affinity Capture-MS, Affinity Capture-Western, Co-purification, tandem affinity purification	association, physical	11839798, 17314511, 25609649, (Europe PMC)	0.53	BioGRID, IntAct, MINT
ACTL8	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
ADAMTS20	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ADAR	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
ADIPOR1	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
ADIPOR1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ADNP	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
AFAP1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
AGK	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
AGPAT1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
AHNAK	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
AHNAK2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
AIFM2	Dosage Lethality, tandem affinity purification	association, genetic	21150319, 22623531, (Europe PMC)	0.35	BioGRID, IntAct
AJAP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
AKAP6	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
AKAP8	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
AKAP8L	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ALDH18A1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ALDH1B1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ALDOA	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
ALPK1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
ALPK3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
AMBRA1	Affinity Capture-Western, anti bait coimmunoprecipitation	physical, physical association	25438055, (Europe PMC)	0.40	BioGRID, IntAct
AMOTL2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ANGPTL4	Co-purification	physical	22573825, (Europe PMC)	NA	BioGRID
ANLN	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ANXA2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
AP2A1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
AP3D1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
AP4B1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
APP	Reconstituted Complex	physical	21244100, (Europe PMC)	NA	BioGRID
ARCN1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
ARF1	anti bait coimmunoprecipitation	physical association	17289033, (Europe PMC)	0.40	IntAct, MINT
ARF4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ARFGAP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ARFGEF2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
ARG1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ARHGEF2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
ARID4B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ARID5B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ARL1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ARMC6	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
ARSB	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ASPM	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ASS1	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
ASS1	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
ATAD2	Affinity Capture-Western, Reconstituted Complex	physical	19843847, (Europe PMC)	NA	BioGRID
ATAD3B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ATM	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ATP1A1	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
ATP2A2	anti bait coimmunoprecipitation, tandem affinity purification	association, physical association	17314511, 17353931, (Europe PMC)	0.56	IntAct
ATP5F1C	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
ATP5F1C	tandem affinity purification	association	17314511, 21150319, (Europe PMC)	0.53	IntAct
ATP5F1D	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
ATP5J2	tandem affinity purification	association	17314511, 21150319, (Europe PMC)	0.53	IntAct
ATP5MF	Affinity Capture-MS	physical	17314511, 21150319, (Europe PMC)	NA	BioGRID
ATP5O	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ATP6V1D	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ATP6V1H	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
ATXN10	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
AXIN1	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association, direct interaction, physical, physical association	19131971, (Europe PMC)	0.62	BioGRID, IntAct, MINT
B4GALT7	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
BAHCC1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
BCL2	Affinity Capture-Western, Co-localization	physical	15210690, (Europe PMC)	NA	BioGRID
BCO1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
BCR	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
BICRA	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
BIN1	Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, nuclear magnetic resonance, two hybrid	direct interaction, physical, physical association	10380878, 15992821, (Europe PMC)	0.51, 0.59	BioGRID, IntAct, MINT
BLM	Affinity Capture-Western, Reconstituted Complex	physical	23750012, (Europe PMC)	NA	BioGRID
BMPR1A	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
BNIP2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
BOK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
BPTF	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
BRCA1	Affinity Capture-Western, Co-localization, Reconstituted Complex, Two-hybrid	physical	11916966, 12646176, 14612409, 20215511, 9788437, (Europe PMC)	NA	BioGRID
BRD3	Reconstituted Complex, display technology, tandem affinity purification	physical, physical association	20195357, (Europe PMC)	0.52	BioGRID, IntAct
BRD4	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
BRD8	Affinity Capture-MS	physical	20946988, (Europe PMC)	NA	BioGRID
BRPF1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
BRPF1	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
BRWD1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
BTAF1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
BTK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
BTRC	Affinity Capture-Western, Biochemical Activity	physical	20852628, (Europe PMC)	NA	BioGRID
BUB1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
C17orf49	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
C1QBP	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
C2orf16	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
C4A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CACNA1G	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CALCOCO2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CALD1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CALM1	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
CAMK1G	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CAMK2D	Affinity Capture-MS, Dosage Lethality, tandem affinity purification	association, genetic, physical	21150319, 22623531, (Europe PMC)	0.35	BioGRID, IntAct
CAMK2G	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CARM1	Affinity Capture-Western	physical	15616592, (Europe PMC)	NA	BioGRID
CAVIN1	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
CAVIN1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CAVIN3	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
CAVIN3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CBFB	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
CCAR2	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, cosedimentation through density gradient, tandem affinity purification, two hybrid	association, physical, physical association	17314511, 17353931, 22190494, (Europe PMC)	0.75	BioGRID, IntAct
CCM2L	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CCNH	Reconstituted Complex	physical	11673469, (Europe PMC)	NA	BioGRID
CCNK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CCNT1	Affinity Capture-Western, Reconstituted Complex	physical	11673469, 12944920, 17700062, 19818711, (Europe PMC)	NA	BioGRID
CCT2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CCT3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CCT4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CCT5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CCT6A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CCT8	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CD6	Affinity Capture-Western	physical	10899308, (Europe PMC)	NA	BioGRID
CDC26	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CDC42EP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CDC6	Reconstituted Complex	physical	10899308, (Europe PMC)	NA	BioGRID
CDC73	Affinity Capture-Western, Protein-peptide	physical	26687678, (Europe PMC)	NA	BioGRID
CDCA7L	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation	physical, physical association	15994933, 16829576, (Europe PMC)	0.40	BioGRID, IntAct
CDH5	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CDK1	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
CDK12	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CDK16	Synthetic Lethality	genetic	25495526, (Europe PMC)	NA	BioGRID
CDK2	Dosage Lethality, Synthetic Lethality	genetic	22623531, 25495526, (Europe PMC)	NA	BioGRID
CDK4	Biochemical Activity, Two-hybrid, protein kinase assay, two hybrid array	phosphorylation reaction, physical, physical association	21988832, 22094256, (Europe PMC)	0.59	BioGRID, IntAct
CDK5RAP2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CDK6	Biochemical Activity, protein kinase assay	phosphorylation reaction, physical	22094256, (Europe PMC)	0.44	BioGRID, IntAct
CDK8	Reconstituted Complex	physical	11673469, (Europe PMC)	NA	BioGRID
CDK9	Affinity Capture-Western, Reconstituted Complex	physical	11673469, 12944920, 17700062, 19818711, 26687678, (Europe PMC)	NA	BioGRID
CDKN1B	Affinity Capture-Western, PCA	physical	26701207, (Europe PMC)	NA	BioGRID
CDKN2A	Affinity Capture-Western	physical	17289033, 20308430, 23277542, (Europe PMC)	NA	BioGRID
CDR2	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	10465786, 20383333, (Europe PMC)	NA	BioGRID
CDV3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CDYL	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
CDYL	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CEBPA	Affinity Capture-Western	physical	12873812, (Europe PMC)	NA	BioGRID
CEBPB	Affinity Capture-Western	physical	12873812, (Europe PMC)	NA	BioGRID
CEBPZ	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
CECR2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CENPF	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
CENPO	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CENPV	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CEP170	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CEP55	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CEP57	Reconstituted Complex, display technology, tandem affinity purification	physical, physical association	20195357, (Europe PMC)	0.52	BioGRID, IntAct
CEPT1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CFL1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CHAF1B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CHCHD3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
CHD4	Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, (Europe PMC)	0.50	BioGRID, IntAct
CHD5	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
CHD9	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
CHTF18	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CHUK	Affinity Capture-Western, anti bait coimmunoprecipitation, confocal microscopy	colocalization, physical, physical association	21575199, (Europe PMC)	0.46	BioGRID, IntAct
CIP2A	Affinity Capture-Western, Reconstituted Complex	physical	17632056, (Europe PMC)	NA	BioGRID
CIP2A	anti tag coimmunoprecipitation, pull down	direct interaction, physical association	17632056, (Europe PMC)	0.54	IntAct
CKAP4	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
CLEC11A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CLSTN1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CNMD	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
CNMD	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CNOT11	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CNOT4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CNTN5	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
COPB2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
COPG1	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
COPG2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CPS1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CPSF1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
CPSF2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CRADD	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CREBBP	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, Two-hybrid	physical	12776737, 16878156, (Europe PMC)	NA	BioGRID
CROCC	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CSE1L	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
CSF1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CSMD2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CSNK1E	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CSNK2A1	Biochemical Activity	physical	12149649, (Europe PMC)	NA	BioGRID
CSPP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CTBP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CTNND1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
CTPS1	Affinity Capture-MS, Dosage Lethality	genetic, physical	21150319, 22623531, (Europe PMC)	NA	BioGRID
CTPS1	anti bait coimmunoprecipitation, tandem affinity purification	association, physical association	17353931, 21150319, (Europe PMC)	0.56	IntAct
CTR9	Affinity Capture-Western, tandem affinity purification	association, physical	21150319, 26687678, (Europe PMC)	0.35	BioGRID, IntAct
CTSD	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CUL1	Affinity Capture-Western	physical	12769844, (Europe PMC)	NA	BioGRID
CUL4A	Affinity Capture-Western	physical	20551172, (Europe PMC)	NA	BioGRID
CXXC1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
CYBA	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CYC1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
CYP2U1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
CYR61	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DACT1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DCAF8	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
DCLK1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
DCTN1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
DDB1	Affinity Capture-Western	physical	20551172, (Europe PMC)	NA	BioGRID
DDB2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
DDX1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DDX17	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
DDX20	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
DDX24	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17353931, 21150319, (Europe PMC)	0.56	BioGRID, IntAct
DDX3X	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
DDX47	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DDX51	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DDX52	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DENND3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DENND6B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DHX15	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DHX37	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
DHX58	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DIAPH3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
DIMT1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DIP2B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DIRAS2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DMAP1	Affinity Capture-Western	physical	20946988, (Europe PMC)	NA	BioGRID
DNAAF5 {ECO:0000303\|PubMed:25232951,	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
DNAJA2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DNAJA3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DNAJB11	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
DNAJB12	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
DNAJB12	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DNAJB6	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DNM2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
DNMT3A	Affinity Capture-Western, Reconstituted Complex	physical	15616584, 19786833, (Europe PMC)	NA	BioGRID
DOCK7	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DPM1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
DSP	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
DUSP15	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DYNC1H1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
DYNC1LI1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
DYNLRB1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
EBI-1058428	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058461	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058587	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058623	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058683	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058689	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058844	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058847	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1058859	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EBI-1648030	pull down	association, physical association	17728244, (Europe PMC)	0.50	IntAct
EBI-1648054	pull down	association	17728244, (Europe PMC)	0.35	IntAct
EBI-3962679	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
EBI-4399559	pull down	physical association	18413597, (Europe PMC)	0.40	IntAct
ECSIT	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
ECT2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EEF1G	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
EFNA5	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
EFNB1	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
EFTUD2	Affinity Capture-MS, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, cosedimentation through density gradient, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.68	BioGRID, IntAct
EHHADH	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
EIF3E	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
EIF3I	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
EIF3I	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
EIF4A1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
EIF4ENIF1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ELAVL1	Affinity Capture-RNA	physical	19322201, (Europe PMC)	NA	BioGRID
ELF3	Biochemical Activity	physical	1651323, (Europe PMC)	NA	BioGRID
ELFN1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ELMSAN1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ELP1	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
ELP1	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
ENSG00000003402	chromatin immunoprecipitation assay	association	22266862, (Europe PMC)	0.35	IntAct
ENSG00000012048	chromatin immunoprecipitation assay	association	21668996, (Europe PMC)	0.35	IntAct
ENSG00000084774	chromatin immunoprecipitation assay	association	17157259, 24951594, (Europe PMC)	0.53	IntAct
ENSG00000089009	chromatin immunoprecipitation assay	association	23217706, (Europe PMC)	0.35	IntAct
ENSG00000100316	chromatin immunoprecipitation assay	association	23217706, (Europe PMC)	0.35	IntAct
ENSG00000114315	chromatin immunoprecipitation assay	association	24951594, (Europe PMC)	0.35	IntAct
ENSG00000115053	chromatin immunoprecipitation assay	association	24951594, (Europe PMC)	0.35	IntAct
ENSG00000124762	chromatin immunoprecipitation assay	association	15084259, (Europe PMC)	0.35	IntAct
ENSG00000125691	chromatin immunoprecipitation assay	association	23217706, (Europe PMC)	0.35	IntAct
ENSG00000134057	chromatin immunoprecipitation assay	association	17157259, (Europe PMC)	0.35	IntAct
ENSG00000134333	chromatin immunoprecipitation assay	association	24951594, (Europe PMC)	0.35	IntAct
ENSG00000134419	chromatin immunoprecipitation assay	association	23217706, (Europe PMC)	0.35	IntAct
ENSG00000135446	chromatin immunoprecipitation assay	association	24951594, (Europe PMC)	0.35	IntAct
ENSG00000145545	chromatin immunoprecipitation assay	association	24951594, (Europe PMC)	0.35	IntAct
ENSG00000177606	chromatin immunoprecipitation assay	association	22266862, (Europe PMC)	0.35	IntAct
EP300	Affinity Capture-Western, Biochemical Activity, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation	physical, physical association	15616592, 16126174, 16287840, 17157259, (Europe PMC)	0.40	BioGRID, IntAct
EP400	Affinity Capture-MS, Affinity Capture-Western, Co-localization, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	association, physical, physical association	11509179, 17314511, 18413597, 20946988, 21150319, (Europe PMC)	0.40, 0.67	BioGRID, IntAct
EPC1	Affinity Capture-MS, tandem affinity purification	association, physical	20946988, 21150319, (Europe PMC)	0.35	BioGRID, IntAct
EPC2	Affinity Capture-MS	physical	20946988, (Europe PMC)	NA	BioGRID
EPPK1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
ERBIN	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
ERBIN	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ERC1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
ERCC3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ERN1	Synthetic Lethality	genetic	25495526, (Europe PMC)	NA	BioGRID
ERP44	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ESR1	Affinity Capture-Western	physical	16455494, (Europe PMC)	NA	BioGRID
ETFA	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ETV3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
ETV6	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
EU154351.1	chromatin immunoprecipitation assay	association	23079660, (Europe PMC)	0.35	IntAct
EU154353.1	chromatin immunoprecipitation assay	association	23079660, (Europe PMC)	0.35	IntAct
EXOC1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EXOC3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
EXOC4	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
EXOSC1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
EYA1	Affinity Capture-Western, Biochemical Activity	physical	27795300, (Europe PMC)	NA	BioGRID
EZH2	chromatin immunoprecipitation assay	association	23079660, (Europe PMC)	0.35	IntAct
FAF2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FAM117B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FAM122B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FAM131C	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
FANCD2	Affinity Capture-MS, Co-localization, tandem affinity purification	association, physical	17314511, 24658369, (Europe PMC)	0.35	BioGRID, IntAct
FANCI	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
FANCM	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FASTKD1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FASTKD2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
FBL	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
FBXO5	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
FBXO8	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex	physical	20848231, (Europe PMC)	NA	BioGRID
FBXW7	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	15103331, 15150404, 15498494, 17157259, 17314511, 17646408, 17873522, 20848231, 20970423, 22524983, 23750012, 25716680, 25720964, 27795300, 28007894, 28209614, (Europe PMC)	NA	BioGRID
FBXW7	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	association, physical association	17157259, 17314511, 23791182, (Europe PMC)	0.67	IntAct
FBXW8	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid	association, physical, physical association	17314511, (Europe PMC)	0.57	BioGRID, IntAct
FERMT3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FHL2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
FLNA	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
FN1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
FOSL1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
FOSL2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FOXC2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FOXO3	Affinity Capture-Western	physical	18393360, (Europe PMC)	NA	BioGRID
FOXO3	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	physical association	18393360, (Europe PMC)	0.52	IntAct
FOXO6	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
FOXP1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
FOXR1	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, 26186194, 28514442, (Europe PMC)	0.35	BioGRID, IntAct, MINT
FOXR2	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, 26186194, 28514442, (Europe PMC)	0.35	BioGRID, IntAct, MINT
FRMD6	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FRMPD4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
FZR1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
GABRR1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
GALR3	Affinity Capture-MS	physical	20848231, (Europe PMC)	NA	BioGRID
GANAB	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
GCDH	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
GCHFR	Affinity Capture-MS	physical	20848231, (Europe PMC)	NA	BioGRID
GCN1	Affinity Capture-MS, Two-hybrid	physical	17314511, 17353931, 20936779, (Europe PMC)	NA	BioGRID
GCN1	tandem affinity purification, two hybrid pooling approach	association, physical association	17314511, 20936779, (Europe PMC)	0.55	IntAct
GEMIN4	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
GFPT1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
GIGYF2 {ECO:0000303\|PubMed:12771153,	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
GLI1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
GLUD2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
GNL3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
GNRHR	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
GPR158	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
GPX2	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
GRK1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
GRK3	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
GSK3A	Affinity Capture-Western, Reconstituted Complex	physical	14563837, (Europe PMC)	NA	BioGRID
GSK3B	Affinity Capture-Western, Split renilla luciferase complementation, Synthetic Lethality, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	association, genetic, physical, physical association	14563837, 19131971, 20713710, 21150319, 25495526, (Europe PMC)	0.37, 0.60	BioGRID, IntAct, MINT
GTF2F1	Reconstituted Complex	physical	8755740, (Europe PMC)	NA	BioGRID
GTF2H4	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
GTF2I	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, tandem affinity purification	association, physical	17314511, 8377829, (Europe PMC)	0.35	BioGRID, IntAct
GTF3C1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
GTF3C2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
GTF3C3	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
GTF3C4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
H2AFZ	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
H3F3A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HADHA	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
HADHB	Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification	association, physical	17314511, 21150319, 26496610, (Europe PMC)	0.64	BioGRID, IntAct
HASPIN	Affinity Capture-MS, Dosage Lethality	genetic, physical	17314511, 22623531, (Europe PMC)	NA	BioGRID
HASPIN	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
HAUS7	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
HBP1	Affinity Capture-Western, Two-hybrid	physical	20008325, (Europe PMC)	NA	BioGRID
HCFC2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HCK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
HDAC1	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	association, physical	17314511, 18003922, 18271930, 22286234, 24951594, 26496610, (Europe PMC)	0.69	BioGRID, IntAct
HDAC2	Affinity Capture-MS, Affinity Capture-Western, display technology, tandem affinity purification	association, physical, physical association	17314511, 20195357, 22286234, (Europe PMC)	0.56	BioGRID, IntAct
HDAC3	Affinity Capture-Western, anti bait coimmunoprecipitation, chromatin immunoprecipitation assay	association, physical	18483244, 22002311, 23079660, (Europe PMC)	0.46	BioGRID, IntAct
HEATR1	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
HEATR3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
HECTD3	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
HELLS	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
HELLS	anti bait coimmunoprecipitation, tandem affinity purification	association, physical association	17314511, 17353931, (Europe PMC)	0.56	IntAct
HELZ	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
HIF1A	Affinity Capture-Western	physical	15071503, (Europe PMC)	NA	BioGRID
HIGD1A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HIRA	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HIST1H1A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HIST1H2AB	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HIST1H2BL	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HIST1H2BM	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HIST1H4A	chromatin immunoprecipitation assay	association	23079660, (Europe PMC)	0.35	IntAct
HK1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HNRNPA0	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HNRNPC	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17353931, 21150319, (Europe PMC)	0.56	BioGRID, IntAct
HNRNPD	Protein-RNA	physical	23603392, (Europe PMC)	NA	BioGRID
HNRNPF	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HNRNPK	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HNRNPU	Affinity Capture-Western	physical	19578763, (Europe PMC)	NA	BioGRID
HOXA10	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HOXB5	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HPS1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
HSD17B4	Dosage Lethality, tandem affinity purification	association, genetic	21150319, 22623531, (Europe PMC)	0.35	BioGRID, IntAct
HSP90AA1	Affinity Capture-Western	physical	12644583, (Europe PMC)	NA	BioGRID
HSPA1A	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
HSPA8	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
HSPB1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
HSPD1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HSPH1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
HUWE1	Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex, tandem affinity purification	association, physical	16269333, 17314511, 18488021, 26279298, (Europe PMC)	0.35	BioGRID, IntAct
ICA1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
IDH3A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IDH3B	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IDH3G	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IGF2BP1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IGF2BP2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
IGF2BP3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
IGF2R	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
IK	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
IKBKG	Affinity Capture-Western, anti tag coimmunoprecipitation, fluorescence microscopy	colocalization, physical, physical association	20970423, (Europe PMC)	0.46	BioGRID, IntAct, MINT
IKZF2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
IL16	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
IL1B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
IL4R	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ILVBL	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IMMT	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ING4	Protein-RNA	physical	23603392, (Europe PMC)	NA	BioGRID
INSM1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
IPO11	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
IPO13	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IPO4	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
IPO7	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IPO9	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
IQCE	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
IQGAP1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
IQGAP2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
IQGAP3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IRAK1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
IRS2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
IRS4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ITGAL	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ITGB5	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
JUN	Affinity Capture-Western, tandem affinity purification	association, physical	20232342, 21150319, (Europe PMC)	0.35	BioGRID, IntAct
KALRN	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KANK2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KARS	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KAT2A	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	10611234, 12660246, 16287840, 17967894, 20691906, (Europe PMC)	NA	BioGRID
KAT2B	Biochemical Activity	physical	15572685, (Europe PMC)	NA	BioGRID
KAT5	Affinity Capture-Western, Reconstituted Complex	physical	12776177, 18003922, 20946988, (Europe PMC)	NA	BioGRID
KCNG3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KCTD2	Affinity Capture-Western	physical	28060381, (Europe PMC)	NA	BioGRID
KDM1A	Two-hybrid, two hybrid	physical, physical association	23455924, (Europe PMC)	0.37	BioGRID, IntAct, MINT
KDM5B	Affinity Capture-Western	physical	22371483, (Europe PMC)	NA	BioGRID
KIAA0319	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KIAA2026	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KIDINS220	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
KIF12	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KIF18A	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
KIF20B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KIF25	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KLF10	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KLHL5	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
KMT2A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KNDC1	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
KNDC1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
KPNA2	Affinity Capture-MS, Two-hybrid, tandem affinity purification, two hybrid array	association, physical, physical association	17314511, 21988832, (Europe PMC)	0.55	BioGRID, IntAct
KPNA4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
KPNB1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
LAS1L	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
LATS1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
LATS1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
LBR	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
LBX2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
LCN12	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
LDOC1	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
LGALS1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
LGALS7	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
LIMK2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
LIMS1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
LMNA	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
LMO7	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
LMTK3	Synthetic Lethality	genetic	25495526, (Europe PMC)	NA	BioGRID
LONP1	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
LONP1	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
LOX	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
LRP1B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
LRPPRC	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, 21150319, (Europe PMC)	0.67	BioGRID, IntAct
LRRC59	Affinity Capture-MS	physical	20848231, (Europe PMC)	NA	BioGRID
MAATS1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MAGEB10	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MAGED2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
MAGI1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MAP1A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MAP2K1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
MAP2K3	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MAP2K7	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MAP3K1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MAP3K13	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MAP3K20	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
MAP3K20	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
MAP3K5	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MAP3K7	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MAP7D1	anti bait coimmunoprecipitation, tandem affinity purification	association, physical association	17353931, 21150319, (Europe PMC)	0.56	IntAct
MAPK1	Reconstituted Complex	physical	15210690, 7957875, (Europe PMC)	NA	BioGRID
MAPK3	Reconstituted Complex	physical	15210690, (Europe PMC)	NA	BioGRID
MAPK8	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	10551811, (Europe PMC)	NA	BioGRID
MAPKAP1	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
MARS	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
MAST4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MATK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MATN4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MATR3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
MAX	Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure, Co-fractionation, FRET, Reconstituted Complex, Two-hybrid	physical	10229200, 10319872, 10465786, 10593926, 10611234, 10918583, 12391307, 12553908, 12584560, 12660246, 12821782, 12824180, 14749374, 15572685, 16140957, 16287840, 16352593, 16596619, 16705173, 17289033, 17314511, 17353931, 17418410, 17471507, 17643117, 17700062, 18003922, 19578763, 19623651, 2006410, 20382893, 20936779, 20946988, 21150319, 21988832, 23816886, 25522242, 25609649, 26496610, 8224841, 9184233, 9528857, 9680483, 9708738, (Europe PMC)	NA	BioGRID
MAX	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, nuclear magnetic resonance, proximity ligation assay, tandem affinity purification, two hybrid, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach	association, direct interaction, physical association	12821782, 16352593, 16606833, 17157259, 17314511, 17353931, 17418410, 18620061, 20691906, 20936779, 21150319, 21807113, 21988832, 24951594, 25609649, 26267534, 26496610, 27705803, 9680483, (Europe PMC)	0.35, 0.98	IntAct, MINT
MBD3	anti tag coimmunoprecipitation	association, physical association	24048479, (Europe PMC)	0.50	IntAct
MCAT	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
MCF2L2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MCL1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MCM3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
MCM4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MCM7	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.73	BioGRID, IntAct
MCTP2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MCU	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
MCU	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
MDN1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
MED1	Reconstituted Complex	physical	17967894, (Europe PMC)	NA	BioGRID
MED12L	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MED16	Reconstituted Complex	physical	17967894, (Europe PMC)	NA	BioGRID
MEN1	Affinity Capture-Western, Reconstituted Complex	physical	19818711, (Europe PMC)	NA	BioGRID
METTL13	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
METTL3	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
METTL3	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
MFGE8	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MFHAS1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MIB1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MICALL2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
MIPEP	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
MKL1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MKLN1	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
MLH1	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	12584560, (Europe PMC)	NA	BioGRID
MLH3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
MMS19	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
MMS19	anti bait coimmunoprecipitation, tandem affinity purification	association, physical association	17314511, 17353931, (Europe PMC)	0.56	IntAct
MNT	Affinity Capture-Western	physical	18271930, (Europe PMC)	NA	BioGRID
MOGS	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MRGBP	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MRPL14	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MRPL53	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
MRPL58	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MRPS22	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MRPS34	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MSH2	Affinity Capture-MS, Affinity Capture-Western, tandem affinity purification	association, physical	12584560, 17314511, (Europe PMC)	0.35	BioGRID, IntAct
MSH3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MSH6	Affinity Capture-MS	physical	17314511, 17353931, (Europe PMC)	NA	BioGRID
MSH6	anti bait coimmunoprecipitation, tandem affinity purification	association, physical association	17314511, 17353931, (Europe PMC)	0.56	IntAct
MTHFD1L	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
MTRF1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MUC3A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MUC5AC	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MYBBP1A	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
MYC	Affinity Capture-MS, tandem affinity purification	association, physical	20848231, 21150319, 25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
MYCBP	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	12223483, 9797456, (Europe PMC)	0.37	BioGRID, IntAct
MYCBP2	Affinity Capture-Western, Far Western	physical	26517351, 9689053, (Europe PMC)	NA	BioGRID
MYCN	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
MYLK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MYLK3	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MYO18A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MYO1B	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
MYO1D	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
MYO3B	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
MYO5A	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
MYO5C	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MYO9A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MYO9B	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
MZT2B	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
NABP2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
NAIP	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NAP1L1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
NAV2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NAV3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NCAPD3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
NCAPG2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
NCBP2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
NCL	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NCOR1	Synthetic Lethality, tandem affinity purification	association, genetic	21150319, 22157079, (Europe PMC)	0.35	BioGRID, IntAct
NCOR2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NDRG1	Affinity Capture-Western	physical	28456659, (Europe PMC)	NA	BioGRID
NDUFA5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NDUFA8	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NDUFAF3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
NDUFB10	Synthetic Lethality	genetic	22157079, (Europe PMC)	NA	BioGRID
NDUFS1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NDUFS2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
NDUFS3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NECAB3	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
NEIL1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
NEK11	Two-hybrid	physical	21988832, (Europe PMC)	NA	BioGRID
NEK11	two hybrid array	physical association	21988832, (Europe PMC)	0.37	IntAct
NEK2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
NEK9	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NFE2L2	Affinity Capture-Western	physical	20232342, 22942279, (Europe PMC)	NA	BioGRID
NFIL3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NFYB	Affinity Capture-Western, Reconstituted Complex	physical	11282029, (Europe PMC)	NA	BioGRID
NFYC	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	10446203, (Europe PMC)	NA	BioGRID
NLRX1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
NMI	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, beta galactosidase complementation	physical, physical association	10597290, 11916966, (Europe PMC)	0.37	BioGRID, IntAct
NOC2L	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
NOL11	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
NOL9	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
NOMO3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NONO	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
NOP56	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
NOTCH3	Reconstituted Complex	physical	25356737, (Europe PMC)	NA	BioGRID
NPC1L1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NPR1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NPTX2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NQO2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
NR1H3	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
NRDC	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
NRXN3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
NTRK1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
NUCB1	Two-hybrid, two hybrid	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
NUP133	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
NUP153	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
NUP188	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
NUP205	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
NUP93	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17353931, 21150319, (Europe PMC)	0.56	BioGRID, IntAct
NUP98	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
OAT	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
OBSCN	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
OPA1	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17353931, 21150319, (Europe PMC)	0.56	BioGRID, IntAct
OPHN1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
OTUD4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
P3H1	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
P3H1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
P4HA1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PACSIN1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
PADI2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PAK2	Affinity Capture-Western, Biochemical Activity	physical	14749374, 16081735, (Europe PMC)	NA	BioGRID
PAK6	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PALD1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PARP10	Affinity Capture-Western, Co-localization, Reconstituted Complex	physical	15674325, 22992334, (Europe PMC)	NA	BioGRID
PBK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PCBD1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PCBP1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PCBP2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PDCD11	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
PDCD6	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
PDHA2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PDK1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PDLIM4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PDLIM7	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
PDS5A	Affinity Capture-MS	physical	17353931, (Europe PMC)	NA	BioGRID
PDS5A	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
PDS5B	anti bait coimmunoprecipitation, tandem affinity purification	association, physical association	17353931, 21150319, (Europe PMC)	0.56	IntAct
PDZD2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
PELO	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PES1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PFDN2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PFDN5	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation	association, physical	11567024, 11585818, 11844794, 17728244, 22844532, 9792694, (Europe PMC)	0.35	BioGRID, IntAct
PGAP1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
PGD	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PHF20	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PHF6	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PHKG2	Synthetic Lethality	genetic	25495526, (Europe PMC)	NA	BioGRID
PHLDB2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
PI4KB	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PIAS2	Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical, physical association	17418410, 17471507, (Europe PMC)	0.50	BioGRID, IntAct
PIM1	Affinity Capture-Western	physical	17643117, (Europe PMC)	NA	BioGRID
PIN1	Affinity Capture-Western, anti bait coimmunoprecipitation, isothermal titration calorimetry, nuclear magnetic resonance, surface plasmon resonance	association, direct interaction, physical	15048125, 19131971, 26655473, (Europe PMC)	0.71	BioGRID, IntAct, MINT
PITX2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PKM	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PKN1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PKP1	Affinity Capture-MS, tandem affinity purification	association, physical	25609649, (Europe PMC)	0.35	BioGRID, IntAct, MINT
PLA2G4A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PLAU	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
PLEKHH1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PLIN3	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
PLK1	Affinity Capture-MS, Biochemical Activity, tandem affinity purification	association, physical	17314511, 27773673, (Europe PMC)	0.35	BioGRID, IntAct
PLOD2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PLOD3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PML	Affinity Capture-Western, Reconstituted Complex, tandem affinity purification	association, physical	15735755, 17146439, 21150319, (Europe PMC)	0.35	BioGRID, IntAct
PNO1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
POLA1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
POLD1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
POLE	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
POLG	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
POLH	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
POLR2A	Affinity Capture-MS, chromatin immunoprecipitation assay, tandem affinity purification	association, physical	17314511, 23079660, (Europe PMC)	0.53	BioGRID, IntAct
POLR2B	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
POLR2E	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
POLR2I	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
POLR3A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
POP4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PPA2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PPIP5K2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PPP1CA	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PPP1R15A	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
PPP1R2	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
PPP2CA	Affinity Capture-Western, Biochemical Activity, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	association, physical	17632056, 19131971, 25438055, (Europe PMC)	0.46	BioGRID, IntAct, MINT
PPP2R3B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PPP2R5A	Affinity Capture-Western, anti bait coimmunoprecipitation	association, physical	19131971, (Europe PMC)	0.35	BioGRID, IntAct, MINT
PPP6C	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PPT1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PRC1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PRDX1	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
PREX2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PRG4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PRKAR1B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PRKCD	Synthetic Lethality	genetic	25495526, (Europe PMC)	NA	BioGRID
PRKDC	Affinity Capture-MS, Synthetic Lethality, tandem affinity purification	association, genetic, physical	17314511, 25495526, (Europe PMC)	0.35	BioGRID, IntAct
PRPF6	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, 21150319, (Europe PMC)	0.67	BioGRID, IntAct
PRPF8	Affinity Capture-MS, anti bait coimmunoprecipitation	physical, physical association	17353931, (Europe PMC)	0.40	BioGRID, IntAct
PRR11	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PRRC2A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PSKH2	Synthetic Lethality	genetic	25495526, (Europe PMC)	NA	BioGRID
PSMA1	Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification	association, physical	17314511, 26496610, (Europe PMC)	0.53	BioGRID, IntAct
PSMA2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMA3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
PSMA4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMA5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMA7	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMB1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMB3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMB4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMB5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMC1	tandem affinity purification	association	17314511, 21150319, (Europe PMC)	0.53	IntAct
PSMC2	Affinity Capture-MS, Dosage Lethality, tandem affinity purification	association, genetic, physical	17314511, 22623531, (Europe PMC)	0.35	BioGRID, IntAct
PSMC3	Affinity Capture-MS, Two-hybrid, tandem affinity purification, two hybrid	association, physical, physical association	17314511, 21988832, (Europe PMC)	0.55	BioGRID, IntAct
PSMC4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMC5	Affinity Capture-Western	physical	12963825, (Europe PMC)	NA	BioGRID
PSMC6	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMD2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
PSMD3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PSMD4	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
PSME4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PTBP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
PTGES2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
PTP4A2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
PTPN14	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
PTPN9	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
QPCTL	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RAB11FIP5	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RAD21	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
RAD50	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RAF1	Affinity Capture-MS, Reconstituted Complex, tandem affinity purification	association, physical	17314511, 9315742, (Europe PMC)	0.35	BioGRID, IntAct
RAG1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RALGAPA1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RANBP2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RARS	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RASGRF1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
RASSF7	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
RB1	Two-hybrid	physical	7838535, (Europe PMC)	NA	BioGRID
RBFA	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RBFOX2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RBL1	Affinity Capture-Western	physical	8076603, (Europe PMC)	NA	BioGRID
RBM10	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RBM15	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
RBM39	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RBMS2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RBPJ	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RCN1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RCOR3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RELA	Affinity Capture-Western	physical	12027803, 15616592, (Europe PMC)	NA	BioGRID
REV1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
RFC1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
RFC2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RFC3	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RFC4	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17353931, 21150319, (Europe PMC)	0.56	BioGRID, IntAct
RFC5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RFX7	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RHOBTB1	Synthetic Lethality	genetic	22157079, (Europe PMC)	NA	BioGRID
RIF1	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
RIF1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RIMS2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RIN3	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RIOX1	Affinity Capture-Western	physical	17308053, (Europe PMC)	NA	BioGRID
RNF115	Affinity Capture-Western, Co-localization, Reconstituted Complex	physical	22844532, (Europe PMC)	NA	BioGRID
RNF130	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
RNF130	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RNF4	Reconstituted Complex	physical	27653698, (Europe PMC)	NA	BioGRID
RNGTT	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RNH1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ROBO2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RPL11	Affinity Capture-Western, anti tag coimmunoprecipitation	physical, physical association	17599065, (Europe PMC)	0.40	BioGRID, IntAct, MINT
RPL13	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RPL26L1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RPN1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RPN2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
RPP30	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
RPRD2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RPS16	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RPS2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RPS21	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RPS27L	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
RPS27L	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RRM1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RRP1B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RUNX1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
RUNX2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
RUVBL1	Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, tandem affinity purification	association, physical	11509179, 11839798, 17314511, (Europe PMC)	0.35	BioGRID, IntAct
RUVBL2	Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, tandem affinity purification	association, physical	11839798, 12660246, 17314511, 20509972, (Europe PMC)	0.35	BioGRID, IntAct
SACS	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SAE1	Synthetic Lethality	genetic	22157079, (Europe PMC)	NA	BioGRID
SAMD9L	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SAP130	Reconstituted Complex	physical	12660246, (Europe PMC)	NA	BioGRID
SARS	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SBNO2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SCD	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SCO2	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SCYL1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
SDC4	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
SDF2L1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SDF4	Affinity Capture-MS, anti tag coimmunoprecipitation, tandem affinity purification	association, physical	21150319, 26496610, (Europe PMC)	0.53	BioGRID, IntAct
SDHA	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SDK1	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
SDK1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SEC11C	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SEC31B	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SEC61A1	tandem affinity purification	association	17314511, (Europe PMC)	0.35	IntAct
SENP2	Biochemical Activity	physical	25895136, (Europe PMC)	NA	BioGRID
SERPINH1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SET	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SETX	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SF3B1	Two-hybrid, two hybrid pooling approach	physical, physical association	20936779, (Europe PMC)	0.37	BioGRID, IntAct
SGO2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SH3BP4	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SH3KBP1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
SH3RF1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SHANK2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SHE	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SHOC2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SIN3B	anti bait coimmunoprecipitation, chromatin immunoprecipitation assay, confocal microscopy, proximity ligation assay	association, colocalization, physical association	24951594, (Europe PMC)	0.63	IntAct
SIPA1L3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SIRT1	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, deacetylase assay	direct interaction, physical, physical association	21807113, 22190494, (Europe PMC)	0.60	BioGRID, IntAct
SIRT2	anti tag coimmunoprecipitation	physical association	23217706, (Europe PMC)	0.40	IntAct
SIRT5	anti tag coimmunoprecipitation	physical association	23217706, (Europe PMC)	0.40	IntAct
SIRT6	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation	physical association	23217706, (Europe PMC)	0.52	IntAct
SKIV2L	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
SKP1	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, tandem affinity purification, two hybrid array	association, physical, physical association	12963825, 17314511, 21988832, (Europe PMC)	0.55	BioGRID, IntAct
SKP2	Affinity Capture-Western, PCA, Reconstituted Complex, anti bait coimmunoprecipitation	physical, physical association	12769844, 12963825, 17157259, 23277542, 24259667, 26038816, (Europe PMC)	0.40	BioGRID, IntAct
SLC1A4	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
SLC25A1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SLC25A10	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SLC25A11	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SLC25A12	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SLC25A13	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SLC25A26	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
SLC25A3	Affinity Capture-MS	physical	20848231, (Europe PMC)	NA	BioGRID
SLC39A10	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SLIT2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SMAD2	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	11804592, (Europe PMC)	NA	BioGRID
SMAD3	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	11804592, (Europe PMC)	NA	BioGRID
SMAD7	Affinity Capture-Western	physical	24259667, (Europe PMC)	NA	BioGRID
SMARCA2	Reconstituted Complex	physical	14559996, (Europe PMC)	NA	BioGRID
SMARCA4	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation	physical, physical association	11839798, 14559996, 17353931, (Europe PMC)	0.40	BioGRID, IntAct
SMARCA5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
SMARCAD1	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
SMARCB1	Affinity Capture-Western, Reconstituted Complex, Two-hybrid	physical	10319872, 14559996, (Europe PMC)	NA	BioGRID
SMARCC1	Affinity Capture-MS, Reconstituted Complex, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	14559996, 17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
SMARCC2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
SMC1A	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
SMC2	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
SMC3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
SMC4	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, 21150319, (Europe PMC)	0.67	BioGRID, IntAct
SMC6	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SMTN	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SMYD4	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SNIP1	Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, two hybrid	physical, physical association	17157259, (Europe PMC)	0.63	BioGRID, IntAct
SNRNP200	Affinity Capture-MS, Dosage Lethality, anti bait coimmunoprecipitation, tandem affinity purification	association, genetic, physical, physical association	17314511, 17353931, 22623531, (Europe PMC)	0.56	BioGRID, IntAct
SNRNP70	Reconstituted Complex, display technology	physical, physical association	20195357, (Europe PMC)	0.40	BioGRID, IntAct
SNRPC	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
SNRPD2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SNRPF	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SNW1	Affinity Capture-Western	physical	19818711, (Europe PMC)	NA	BioGRID
SNX19	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SORBS1	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
SP1	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation	association, physical, physical association	11274368, 15780936, 17418410, 18003922, (Europe PMC)	0.50	BioGRID, IntAct
SPATA31E1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SPEG	Affinity Capture-MS, Dosage Lethality, tandem affinity purification	association, genetic, physical	21150319, 22623531, (Europe PMC)	0.35	BioGRID, IntAct
SPTLC1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SQOR	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
SQOR	tandem affinity purification	association	17314511, 21150319, (Europe PMC)	0.53	IntAct
SQSTM1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
SRP14	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
SRP9	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SSBP1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SSR1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
SSR4	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ST6GALNAC6	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
STAG2	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
STUB1	Affinity Capture-Western, Reconstituted Complex	physical	22543587, 28128329, (Europe PMC)	NA	BioGRID
SUCLG1	Affinity Capture-MS	physical	17314511, (Europe PMC)	NA	BioGRID
SUCLG1	tandem affinity purification	association	17314511, 21150319, (Europe PMC)	0.53	IntAct
SUCLG2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
SULF2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
SULT1A2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
SUPT3H	Affinity Capture-Western, Reconstituted Complex	physical	12660246, 17967894, (Europe PMC)	NA	BioGRID
SUV39H1	Dosage Lethality, tandem affinity purification	association, genetic	22623531, 27705803, (Europe PMC)	0.35	BioGRID, IntAct
SUZ12	anti bait coimmunoprecipitation, chromatin immunoprecipitation assay	association	23079660, (Europe PMC)	0.46	IntAct
SYNE1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TADA2A	Reconstituted Complex	physical	12660246, (Europe PMC)	NA	BioGRID
TAF1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
TAF12	Reconstituted Complex	physical	12660246, (Europe PMC)	NA	BioGRID
TAF2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TAF9	Affinity Capture-Western, Reconstituted Complex	physical	12660246, (Europe PMC)	NA	BioGRID
TARSL2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
TBL2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TBP	Reconstituted Complex	physical	8755740, (Europe PMC)	NA	BioGRID
TCF12	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TCP1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TDG	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, 26496610, (Europe PMC)	0.35	BioGRID, IntAct
TENM2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TEX2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TF	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TFAM	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TFAP2A	Affinity Capture-Western, Reconstituted Complex	physical	7729426, (Europe PMC)	NA	BioGRID
TFAP2C	Affinity Capture-Western, Co-localization, Phenotypic Enhancement	genetic, physical	22371483, (Europe PMC)	NA	BioGRID
TIAM1	Affinity Capture-Western, Reconstituted Complex	physical	12446731, (Europe PMC)	NA	BioGRID
TIE1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
TKT	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TMEM131L	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TMEM161A	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
TMEM33	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
TMPO	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TMPRSS11A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TNFRSF18	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TNPO1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TNPO3	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
TNR	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TNS2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TONSL	Two-hybrid, two hybrid array	physical, physical association	21988832, (Europe PMC)	0.37	BioGRID, IntAct
TOP1	Affinity Capture-MS, display technology, tandem affinity purification	association, physical, physical association	17314511, 20195357, (Europe PMC)	0.56	BioGRID, IntAct
TOP2A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TP53	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TP53BP1	display technology, proximity-dependent biotin identification	association, physical association	20195357, 29656893, (Europe PMC)	0.56	IntAct
TP73	Affinity Capture-Western, Reconstituted Complex	physical	11844794, 12080043, (Europe PMC)	NA	BioGRID
TPH1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TPP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TRABD2A	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TRAK1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TRAP1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TRIB1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
TRIM21	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TRIM25	Affinity Capture-RNA	physical	29117863, (Europe PMC)	NA	BioGRID
TRIM28	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
TRIM6	Affinity Capture-Western, Two-hybrid	physical	22328504, (Europe PMC)	NA	BioGRID
TRIO	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
TRIP12	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down	association, direct interaction, physical, physical association	20208519, (Europe PMC)	0.63	BioGRID, IntAct
TRIP13	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
TRMT1L	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TRPC4AP	Affinity Capture-Western	physical	20551172, 26038816, (Europe PMC)	NA	BioGRID
TRPM1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TRRAP	Affinity Capture-MS, Affinity Capture-Western, Co-localization, Dosage Lethality, Reconstituted Complex, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation, tandem affinity purification	association, genetic, physical, physical association	10611234, 11511539, 11839798, 12660246, 16705173, 17314511, 17353931, 19818711, 20946988, 21150319, 22623531, 9708738, (Europe PMC)	0.79	BioGRID, IntAct
TSN	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
TTC27	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TTC5	Affinity Capture-Western	physical	23559008, (Europe PMC)	NA	BioGRID
TTN	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TUBA1A	Affinity Capture-Western	physical	20691906, (Europe PMC)	NA	BioGRID
TUBA4A	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 21150319, (Europe PMC)	0.53	BioGRID, IntAct
TUBB	Affinity Capture-Western	physical	20691906, (Europe PMC)	NA	BioGRID
TUBB3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TUBB6	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TUBG1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TUBGCP2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
TUBGCP4	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
TUFM	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
TUT4	Affinity Capture-MS	physical	21150319, (Europe PMC)	NA	BioGRID
TXK	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
TXN	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
U2SURP	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
UBA1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
UBA2	Synthetic Lethality	genetic	22157079, (Europe PMC)	NA	BioGRID
UBC	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, tandem affinity purification	association, physical association	16996503, 19131971, 21150319, (Europe PMC)	0.69	IntAct, MINT
UBE2I	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
UBE2L3	Affinity Capture-Western	physical	11431533, (Europe PMC)	NA	BioGRID
UBE2O	Synthetic Lethality	genetic	22157079, (Europe PMC)	NA	BioGRID
UBE3C	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
UBR2	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
UBTF	display technology, tandem affinity purification	association, physical association	20195357, 21150319, (Europe PMC)	0.56	IntAct
UNC45A	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
UQCRFS1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
USP10	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
USP2	Biochemical Activity	physical	25895136, (Europe PMC)	NA	BioGRID
USP22	Affinity Capture-Western, Co-localization, Reconstituted Complex	physical	18206973, 28160502, (Europe PMC)	NA	BioGRID
USP28	Affinity Capture-Western, Biochemical Activity	physical	17558397, 17873522, 23389829, 25716680, (Europe PMC)	NA	BioGRID
USP33	Synthetic Lethality	genetic	22157079, (Europe PMC)	NA	BioGRID
USP36	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	25775507, (Europe PMC)	NA	BioGRID
USP36	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
USP37	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	25284584, (Europe PMC)	NA	BioGRID
USP48	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
USP7	Affinity Capture-Western, Reconstituted Complex	physical	27618649, (Europe PMC)	NA	BioGRID
USP9X	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
UST	display technology	physical association	20195357, (Europe PMC)	0.40	IntAct
UTP15	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
VDR	Affinity Capture-Western	physical	23112173, (Europe PMC)	NA	BioGRID
VHL	Affinity Capture-Western	physical	22286234, (Europe PMC)	NA	BioGRID
WDFY3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
WDR5	Affinity Capture-Western, anti bait coimmunoprecipitation	physical, physical association	17353931, 27320920, (Europe PMC)	0.40	BioGRID, IntAct
WDR77	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
WEE1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
WEE2	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
WIPF1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
WNK1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
WWP2	Affinity Capture-Western	physical	26894970, (Europe PMC)	NA	BioGRID
XDH	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
XKRX	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
XPO1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, 26673895, (Europe PMC)	0.35	BioGRID, IntAct
XPO5	Affinity Capture-MS, anti bait coimmunoprecipitation, tandem affinity purification	association, physical, physical association	17314511, 17353931, (Europe PMC)	0.56	BioGRID, IntAct
XPO7	anti bait coimmunoprecipitation	physical association	17353931, (Europe PMC)	0.40	IntAct
XPOT	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
XRCC5	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
XRCC6	Affinity Capture-MS, Affinity Capture-Western, anti tag coimmunoprecipitation, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.46	BioGRID, IntAct
XRN1	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
XYLT1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
YAF2	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
YBX1	Affinity Capture-MS, tandem affinity purification	association, physical	21150319, (Europe PMC)	0.35	BioGRID, IntAct
YEATS4	Affinity Capture-MS, Reconstituted Complex	physical	22068108, 26186194, 28514442, (Europe PMC)	NA	BioGRID
YES1	Dosage Lethality	genetic	22623531, (Europe PMC)	NA	BioGRID
YWHAB	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
YWHAE	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
YWHAQ	Affinity Capture-MS, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
YY1	Reconstituted Complex, Two-hybrid	physical	8266081, (Europe PMC)	NA	BioGRID
ZBTB17	Affinity Capture-Western, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down	direct interaction, physical, physical association	11283613, 16352593, 17418410, 18923429, 19786833, 20426839, 26766587, 9312026, (Europe PMC)	0.78	BioGRID, IntAct, MINT
ZBTB18	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZC3H18	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZC3H7B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZCCHC11	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZFHX3	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZFYVE21	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
ZNF106	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZNF121	Affinity Capture-MS, tandem affinity purification, two hybrid	association, physical, physical association	17314511, (Europe PMC)	0.48	BioGRID, IntAct
ZNF281	Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, tandem affinity purification	association, physical	17314511, (Europe PMC)	0.35	BioGRID, IntAct
ZNF354B	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZNF541	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZNF586	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZNF703	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZNF740	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct
ZZEF1	tandem affinity purification	association	21150319, (Europe PMC)	0.35	IntAct

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