Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - Central carbon metabolism in cancer - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| PGAM2 | P15259 | Protein substrates of this phosphatase are not reported yet | 2,3-bisphospho-D-glyceric acid, |
| PGAM1 | P18669 | Protein substrates of this phosphatase are not reported yet | 2,3-bisphospho-D-glyceric acid, |
| PTEN | P60484 | PDGFRB, CREB1, SHC1, PTEN, PTK2, PTK6, | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate, 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate, 1D-myo-inositol 1,3,4,5-tetrakisphosphate, 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate, 1-phosphatidyl-1D-myo-inositol 3-phosphate, |
| PGAM4 | Q8N0Y7 | Protein substrates of this phosphatase are not reported yet | 2,3-bisphospho-D-glyceric acid, |
| TIGAR | Q9NQ88 | Protein substrates of this phosphatase are not reported yet | keto-D-fructose 1,6-bisphosphate, beta-D-fructofuranose 2,6-bisphosphate, D-fructofuranose 1,6-bisphosphate, |
| Protein substrates in this pathway |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:15946 | C00085 | keto-D-fructose 6-phosphate |  | MDP1, |
| CHEBI:61553 | C00085 | D-fructofuranose 6-phosphate | | MDP1, |
| CHEBI:16905 | C00354 | keto-D-fructose 1,6-bisphosphate |  | FBP1, FBP2, NANP, TIGAR, |
| CHEBI:37736 | C00354 | D-fructofuranose 1,6-bisphosphate | | FBP1, FBP2, NANP, TIGAR, |
| CHEBI:28602 | C00665 | beta-D-fructofuranose 2,6-bisphosphate |  | PFKFB1, PFKFB2, PFKFB3, PFKFB4, TIGAR, |