Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
299 KEGG pathways;
876 Reactome pathways;
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023




Gene Name PFKFB3 (QuickGO)
Interactive visualization PFKFB3 structures
(A quick tutorial to explore the interctive visulaization)

Synonyms PFKFB3
Protein Name PFKFB3
Alternative Name(s)
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3;6PF-2-K/Fru-2,6-P2ase 3;PFK/FBPase 3;6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme;Renal carcinoma antigen NY-REN-56;iPFK-2;6-phosphofructo-2-kinase;;Fructose-2,6-bisphosphatase;;
EntrezGene ID5209   (Comparitive Toxicogenomics)
UniProt AC (Human) Q16875 (protein sequence)
Enzyme ClassEC (BRENDA )
Molecular Weight59609 Dalton
Protein Length520 amino acids (AA)
Genome Browsers NCBI | ENSG00000170525 (Ensembl) | UCSC
Crosslinking annotations Query our ID-mapping table
Orthologues Quest For Orthologues (QFO) | GeneTree
Classification Superfamily: histidine phosphatase (HP) --> Family: PFKFB | Historic class: Phosphoglycerate mutase | CATH ID: | SCOP Fold: HP
Phosphatase activityactive | Catalytic signature motif: unknown
Phosphorylation Network Visualize
Domain organization, Expression, Diseases(show / hide)
Localization, Function, Catalytic activity and Sequence(show / hide)
Motif information from Eukaryotic Linear Motif atlas (ELM)(show / hide)
Gene Ontology (P: Process; F: Function and C: Component terms)(show / hide)