Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - AMPK signaling pathway - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| MAP3K7 | O43318 | PPP2CA, PPP2CB, PPM1B, PPM1L, PPP6C, |
| INSR | P06213 | PTPRF, ACP1, PTPN1, PTPRE, PTPN2, DUSP3, |
| IGF1R | P08069 | PTPN1, |
| EEF2 | P13639 | PPP2CA, PPP2CB, PPM1A, |
| GYS1 | P13807 | ALPP, |
| CREB1 | P16220 | PPP2CA, PPP2CB, PTEN, |
| CD36 | P16671 | ALPI, |
| RPS6KB1 | P23443 | PPP2CA, PPP2CB, PHLPP1, PHLPP2, |
| PIK3R1 | P27986 | PPM1A, PTPRJ, |
| AKT1 | P31749 | ACP1, PHLPP1, PHLPP2, PPP2CA, PPP2CB, PPP1CA, PPP1CB, PPP1CC, CTDSP1, |
| AKT2 | P31751 | PHLPP1, PHLPP2, |
| IRS1 | P35568 | PTPN1, PTPN13, PTPN11, PPP1CA, PPP1CB, PPP1CC, |
| PRKAA1 | Q13131 | PPP2CA, PPP2CB, |
| PPP2R5A | Q15172 | PPP2CA, PPP2CB, |
| AKT3 | Q9Y243 | PHLPP1, PHLPP2, PPP2CA, PPP2CB, |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:16027 | C00020 | adenosine 5'-monophosphate |  | ACPP, ALPL, NT5E, NT5C1A, |
| CHEBI:15946 | C00085 | keto-D-fructose 6-phosphate |  | MDP1, |
| CHEBI:61553 | C00085 | D-fructofuranose 6-phosphate | | MDP1, |
| CHEBI:16905 | C00354 | keto-D-fructose 1,6-bisphosphate |  | FBP1, FBP2, NANP, TIGAR, |
| CHEBI:37736 | C00354 | D-fructofuranose 1,6-bisphosphate | | FBP1, FBP2, NANP, TIGAR, |
| CHEBI:28602 | C00665 | beta-D-fructofuranose 2,6-bisphosphate |  | PFKFB1, PFKFB2, PFKFB3, PFKFB4, TIGAR, |
| CHEBI:17665 | C00668 | alpha-D-glucose 6-phosphate |  | G6PC, G6PC2, G6PC3, IMPA1, |
| CHEBI:17719 | C01172 | beta-D-glucose 6-phosphate |  | G6PC, G6PC2, G6PC3, IMPA1, |
| CHEBI:16618 | C05981 | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate |  | TNS2, FIG4, INPP5B, INPP5E, INPP5K, OCRL, PTEN, PTPRQ, INPP5F, INPP5D, INPPL1, SYNJ1, SYNJ2, TPTE2, |