Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
299 KEGG pathways;
876 Reactome pathways;
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023




Gene Name MAP2K4 (QuickGO)
Interactive visualization of MAP2K4 structures
(A quick tutorial to explore the interctive visulaization)

Representative structure: 3ALN

SynonymsMAP2K4, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1
Protein NameMAP2K4
Alternative Name(s)
Dual specificity mitogen-activated protein kinase kinase 4;MAP kinase kinase 4;MAPKK 4;;JNK-activating kinase 1;MAPK/ERK kinase 4;MEK 4;SAPK/ERK kinase 1;SEK1;Stress-activated protein kinase kinase 1;SAPK kinase 1;SAPKK-1;SAPKK1;c-Jun N-terminal kinase kinase 1;JNKK;
Protein FamilyBelongs to the protein kinase superfamily STE Ser/Thrprotein kinase family MAP kinase kinase subfamily
EntrezGene ID6416   (Comparitive Toxicogenomics)
UniProt AC (Human)P45985 (protein sequence)
Enzyme Class2.7.12.2 (BRENDA )
Molecular Weight44288 Dalton
Protein Length399 amino acids (AA)
Genome Browsers NCBI | ENSG00000065559 (Ensembl) | UCSC
Crosslinking annotations Query our ID-mapping table
Orthologues Quest For Orthologues (QFO) | GeneTree | eggNOG - KOG0984 | eggNOG - ENOG410XT3F
Phosphorylation Network Visualize
Domain organization, Expression, Diseases(show / hide)
Localization, Function, Catalytic activity and Sequence(show / hide)
Motif information from Eukaryotic Linear Motif atlas (ELM)(show / hide)
Gene Ontology (P: Process; F: Function and C: Component terms)(show / hide)