Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
299 KEGG pathways;
876 Reactome pathways;
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023




Gene Name PFKFB4 (QuickGO)
Interactive visualization PFKFB4 structures
(A quick tutorial to explore the interctive visulaization)

Synonyms PFKFB4
Protein Name PFKFB4
Alternative Name(s)
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4;6PF-2-K/Fru-2,6-P2ase 4;PFK/FBPase 4;6PF-2-K/Fru-2,6-P2ase testis-type isozyme;6-phosphofructo-2-kinase;;Fructose-2,6-bisphosphatase;;
EntrezGene ID5210   (Comparitive Toxicogenomics)
UniProt AC (Human) Q16877 (protein sequence)
Enzyme ClassEC (BRENDA )
Molecular Weight54040 Dalton
Protein Length469 amino acids (AA)
Genome Browsers NCBI | ENSG00000114268 (Ensembl) | UCSC
Crosslinking annotations Query our ID-mapping table
Orthologues Quest For Orthologues (QFO) | GeneTree
Classification Superfamily: histidine phosphatase (HP) --> Family: PFKFB | Historic class: Phosphoglycerate mutase | CATH ID: | SCOP Fold: HP
Phosphatase activityactive | Catalytic signature motif: unknown
Domain organization, Expression, Diseases(show / hide)
Localization, Function, Catalytic activity and Sequence(show / hide)
Motif information from Eukaryotic Linear Motif atlas (ELM)(show / hide)
Gene Ontology (P: Process; F: Function and C: Component terms)(show / hide)