DEPOD - human DEPhOsphorylation Database

Basic Information
Phosphatases
Pathway
Interacting Proteins
Phosphorylating Kinases

Gene Name	SNCA (QuickGO)	Interactive visualization of SNCA structures (A quick tutorial to explore the interctive visulaization) Representative structure: 4ZNN
Synonyms	SNCA, NACP, PARK1
Protein Name	SNCA
Alternative Name(s)	Alpha-synuclein;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;NACP;
Protein Family	Belongs to the synuclein family
EntrezGene ID	6622 (Comparitive Toxicogenomics)
UniProt AC (Human)	P37840 (protein sequence)
Enzyme Class	N/A
Molecular Weight	14460 Dalton
Protein Length	140 amino acids (AA)
Genome Browsers	NCBI \| ENSG00000145335 (Ensembl) \| UCSC
Crosslinking annotations	Query our ID-mapping table
Orthologues	Quest For Orthologues (QFO) \| GeneTree \| eggNOG - ENOG410IWI2 \| eggNOG - ENOG4111TDZ
Phosphorylation Network	Visualize

Domain organization, Expression, Diseases

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Localization, Function, Catalytic activity and Sequence

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Motif information from Eukaryotic Linear Motif atlas (ELM)

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Gene Ontology (P: Process; F: Function and C: Component terms)

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GO:0000122	P:negative regulation of transcription by RNA polymerase II
GO:0000287	F:magnesium ion binding
GO:0001774	P:microglial cell activation
GO:0001921	P:positive regulation of receptor recycling
GO:0001933	P:negative regulation of protein phosphorylation
GO:0001956	P:positive regulation of neurotransmitter secretion
GO:0003779	F:actin binding
GO:0005507	F:copper ion binding
GO:0005509	F:calcium ion binding
GO:0005543	F:phospholipid binding
GO:0005576	C:extracellular region
GO:0005615	C:extracellular space
GO:0005634	C:nucleus
GO:0005640	C:nuclear outer membrane
GO:0005737	C:cytoplasm
GO:0005739	C:mitochondrion
GO:0005741	C:mitochondrial outer membrane
GO:0005743	C:mitochondrial inner membrane
GO:0005758	C:mitochondrial intermembrane space
GO:0005759	C:mitochondrial matrix
GO:0005764	C:lysosome
GO:0005791	C:rough endoplasmic reticulum
GO:0005794	C:Golgi apparatus
GO:0005829	C:cytosol
GO:0005840	C:ribosome
GO:0005886	C:plasma membrane
GO:0005938	C:cell cortex
GO:0006631	P:fatty acid metabolic process
GO:0006638	P:neutral lipid metabolic process
GO:0006644	P:phospholipid metabolic process
GO:0006919	P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007006	P:mitochondrial membrane organization
GO:0007568	P:aging
GO:0008017	F:microtubule binding
GO:0008198	F:ferrous iron binding
GO:0008270	F:zinc ion binding
GO:0008344	P:adult locomotory behavior
GO:0010040	P:response to iron(II) ion
GO:0010517	P:regulation of phospholipase activity
GO:0010642	P:negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014048	P:regulation of glutamate secretion
GO:0014059	P:regulation of dopamine secretion
GO:0015629	C:actin cytoskeleton
GO:0016020	C:membrane
GO:0016234	C:inclusion body
GO:0016491	F:oxidoreductase activity
GO:0019894	F:kinesin binding
GO:0019904	F:protein domain specific binding
GO:0022898	P:regulation of transmembrane transporter activity
GO:0030054	C:cell junction
GO:0030424	C:axon
GO:0030426	C:growth cone
GO:0030544	F:Hsp70 protein binding
GO:0030672	C:synaptic vesicle membrane
GO:0031115	P:negative regulation of microtubule polymerization
GO:0031623	P:receptor internalization
GO:0031648	P:protein destabilization
GO:0032026	P:response to magnesium ion
GO:0032410	P:negative regulation of transporter activity
GO:0032496	P:response to lipopolysaccharide
GO:0032769	P:negative regulation of monooxygenase activity
GO:0033138	P:positive regulation of peptidyl-serine phosphorylation
GO:0034341	P:response to interferon-gamma
GO:0034599	P:cellular response to oxidative stress
GO:0035067	P:negative regulation of histone acetylation
GO:0040012	P:regulation of locomotion
GO:0042393	F:histone binding
GO:0042416	P:dopamine biosynthetic process
GO:0042775	P:mitochondrial ATP synthesis coupled electron transport
GO:0042802	F:identical protein binding
GO:0043014	F:alpha-tubulin binding
GO:0043025	C:neuronal cell body
GO:0043027	F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043030	P:regulation of macrophage activation
GO:0043065	P:positive regulation of apoptotic process
GO:0043066	P:negative regulation of apoptotic process
GO:0043154	P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043195	C:terminal bouton
GO:0043274	F:phospholipase binding
GO:0043524	P:negative regulation of neuron apoptotic process
GO:0044212	F:transcription regulatory region DNA binding
GO:0044267	P:cellular protein metabolic process
GO:0044344	P:cellular response to fibroblast growth factor stimulus
GO:0045807	P:positive regulation of endocytosis
GO:0045920	P:negative regulation of exocytosis
GO:0045963	P:negative regulation of dopamine metabolic process
GO:0047485	F:protein N-terminus binding
GO:0048148	P:behavioral response to cocaine
GO:0048156	F:tau protein binding
GO:0048169	P:regulation of long-term neuronal synaptic plasticity
GO:0048471	C:perinuclear region of cytoplasm
GO:0048487	F:beta-tubulin binding
GO:0048488	P:synaptic vesicle endocytosis
GO:0048489	P:synaptic vesicle transport
GO:0050729	P:positive regulation of inflammatory response
GO:0050808	P:synapse organization
GO:0050812	P:regulation of acyl-CoA biosynthetic process
GO:0051219	F:phosphoprotein binding
GO:0051281	P:positive regulation of release of sequestered calcium ion into cytosol
GO:0051583	P:dopamine uptake involved in synaptic transmission
GO:0051585	P:negative regulation of dopamine uptake involved in synaptic transmission
GO:0051612	P:negative regulation of serotonin uptake
GO:0051621	P:regulation of norepinephrine uptake
GO:0051622	P:negative regulation of norepinephrine uptake
GO:0055114	P:oxidation-reduction process
GO:0060079	P:excitatory postsynaptic potential
GO:0060291	P:long-term synaptic potentiation
GO:0060732	P:positive regulation of inositol phosphate biosynthetic process
GO:0070495	P:negative regulation of thrombin-activated receptor signaling pathway
GO:0070555	P:response to interleukin-1
GO:0070840	F:dynein complex binding
GO:0071280	P:cellular response to copper ion
GO:0071872	P:cellular response to epinephrine stimulus
GO:0071902	P:positive regulation of protein serine/threonine kinase activity
GO:0097435	P:supramolecular fiber organization
GO:0098794	C:postsynapse
GO:0099512	C:supramolecular fiber
GO:1901215	P:negative regulation of neuron death
GO:1901216	P:positive regulation of neuron death
GO:1902957	P:negative regulation of mitochondrial electron transport
GO:1903136	NADH to ubiquinone
GO:1903284	F:cuprous ion binding
GO:1903285	P:positive regulation of glutathione peroxidase activity
GO:1903421	P:positive regulation of hydrogen peroxide catabolic process
GO:1903426	P:regulation of synaptic vesicle recycling
GO:1904307	P:regulation of reactive oxygen species biosynthetic process
GO:1904715	P:response to desipramine
GO:1905606	P:negative regulation of chaperone-mediated autophagy

KEGG Pathway
Reactome Pathway

Pathway ID	Pathway Name	Pathway Description (KEGG)
hsa05010	Alzheimer disease	Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. The extracellular Abeta oligomers may activate caspases through activation of cell surface death receptors. Alternatively, intracellular Abeta may contribute to pathology by facilitating tau hyper-phosphorylation, disrupting mitochondria function, and triggering calcium dysfunction. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
hsa05012	Parkinson disease	Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations in alpha-synuclein, UCHL1 (a ubiquitin carboxy-terminal hydrolase L1), parkin, DJ1 (a parkin-associated protein involved with oxidative stress), and PINK1 (a putative serine threonine kinase) are known to cause early-onset PD. Mutations or altered expression of these proteins contributes to the damage and subsequent loss of DA neurons through common mechanisms that result in proteasome dysfunction, mitochondrial impairment, and oxidative stress. The demise of DA neurons located in the SNc leads to a drop in the dopaminergic input to the striatum. This results in a reduced activation of the direct pathway and in a disinhibition of the indirect pathway, which is associated with the elevation of adenosine A2A receptor transmission. Such unbalanced activity of the striatal output pathway is at the basis of the motor impairment observed in PD.

Pathway ID	Pathway Name	Pathway Description (KEGG)
R-HSA-977225	Amyloid fiber formation.	Amyloid is a term used to describe deposits of fibrillar proteins, typically extracellular. The abnormal accumulation of amyloid, amyloidosis, is a term associated with tissue damage caused by amyloid deposition, seen in numerous diseases including neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's. Amyloid deposits consist predominantly of amyloid fibrils, rigid, non-branching structures that form ordered assemblies, characteristically with a cross beta-sheet structure where the sheets run parallel to the direction of the fibril (Sawaya et al. 2007). Often the fibril has a left-handed twist (Nelson & Eisenberg 2006). At least 27 human proteins form amyloid fibrils (Sipe et al. 2010). Many of these proteins have non-pathological functions; the trigger that leads to abnormal aggregations differs between proteins and is not well understood but in many cases the peptides are abnormal fragments or mutant forms arising from polymorphisms, suggesting that the initial event may be aggregation of misfolded or unfolded peptides. Early studies of Amyloid-beta assembly led to a widely accepted model that assembly was a nucleation-dependent polymerization reaction (Teplow 1998) but it is now understood to be more complex, with multiple 'off-pathway' events leading to a variety of oligomeric structures in addition to fibrils (Roychaudhuri et al. 2008), though it is unclear whether these intermediate steps are required in vivo. An increasing body of evidence suggests that these oligomeric forms are primarily responsible for the neurotoxic effects of Amyloid-beta (Roychaudhuri et al. 2008), alpha-synuclein (Winner et al. 2011) and tau (Dance & Strobel 2009, Meraz-Rios et al. 2010). Amyloid oligomers are believed to have a common structural motif that is independent of the protein involved and not present in fibrils (Kayed et al. 2003). Conformation dependent, aggregation specific antibodies suggest that there are 3 general classes of amyloid oligomer structures (Glabe 2009) including annular structures which may be responsible for the widely reported membrane permeabilization effect of amyloid oligomers. Toxicity of amyloid oligomers preceeds the appearance of plaques in mouse models (Ferretti et al. 2011). Fibrils are often associated with other molecules, notably heparan sulfate proteoglycans and Serum Amyloid P-component, which are universally associated and seem to stabilize fibrils, possibly by protecting them from degradation

BioGRID
IntAct
MINT
ALL

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Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
ACTA1	Reconstituted Complex	physical	19553474, (Europe PMC)	NA	BioGRID
ACTB	Affinity Capture-Western	physical	18331289, (Europe PMC)	NA	BioGRID
ADAP2	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
AKAP17A	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
AKT1	Affinity Capture-Western, Far Western	physical	21474915, (Europe PMC)	NA	BioGRID
ANXA6	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
AP1B1	Affinity Capture-Western	physical	18614564, (Europe PMC)	NA	BioGRID
APLP1	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
APP	Affinity Capture-Western, Co-localization, Reconstituted Complex, proximity ligation assay	physical, physical association	18769546, 21832049, 25241761, 7568089, 9163350, (Europe PMC)	0.40	BioGRID, IntAct
ARHGAP15	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
ARPP19	Reconstituted Complex	physical	17893145, (Europe PMC)	NA	BioGRID
ARRB1	Affinity Capture-Western	physical	20448034, (Europe PMC)	NA	BioGRID
BAD	Affinity Capture-Western	physical	15978696, (Europe PMC)	NA	BioGRID
BAG5	Affinity Capture-Western, Reconstituted Complex	physical	21358815, (Europe PMC)	NA	BioGRID
BAX	Co-localization, proximity ligation assay	physical, physical association	25241761, (Europe PMC)	0.40	BioGRID, IntAct
BDH2	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
CALM1	Affinity Capture-Western, Reconstituted Complex	physical	12358748, 12610000, (Europe PMC)	NA	BioGRID
CAV1	Reconstituted Complex	physical	21693152, (Europe PMC)	NA	BioGRID
CBX4	Affinity Capture-Western	physical	21256122, (Europe PMC)	NA	BioGRID
CDC42EP2	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
CDC42EP3	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
CDC42SE1	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
CDK4	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CEP295	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
CGRRF1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
CHMP5	Co-fractionation	physical	22863883, (Europe PMC)	NA	BioGRID
CLTC	Affinity Capture-Western	physical	18614564, (Europe PMC)	NA	BioGRID
CMBL	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
COL7A1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
COX1	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
CRYAB	Co-crystal Structure, Co-fractionation, Reconstituted Complex	physical	15236975, 20197038, 21905118, (Europe PMC)	NA	BioGRID
CSNK1A1	Biochemical Activity	physical	10617630, 16959772, (Europe PMC)	NA	BioGRID
CSNK1D	Biochemical Activity, Co-localization, proximity ligation assay	physical, physical association	16618118, 25241761, (Europe PMC)	0.40	BioGRID, IntAct
CSNK2A1	Biochemical Activity, protein kinase assay	phosphorylation reaction, physical	10617630, 15033366, 19576176, (Europe PMC)	0.44	BioGRID, IntAct
CTNND1	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
CTSD	Biochemical Activity	physical	25617759, (Europe PMC)	NA	BioGRID
DGUOK	Affinity Capture-MS	physical	26186194, (Europe PMC)	NA	BioGRID
DHCR24	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
DMTN	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
DNAAF2	Affinity Capture-MS	physical	26186194, 28514442, (Europe PMC)	NA	BioGRID
DNAJB1	Affinity Capture-Western	physical	17012257, (Europe PMC)	NA	BioGRID
DOCK7	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DYNC1H1	Affinity Capture-MS, Protein-peptide, anti tag coimmunoprecipitation	association, physical	17893145, 26496610, (Europe PMC)	0.35	BioGRID, IntAct
DYNLL1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
DYRK1A	Affinity Capture-Western, Biochemical Activity	physical	16959772, (Europe PMC)	NA	BioGRID
EEF1A1	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
EFTUD2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
EGFR	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
EIF3G	Two-hybrid	physical	21900206, (Europe PMC)	NA	BioGRID
ELK1	Affinity Capture-Western	physical	11279280, (Europe PMC)	NA	BioGRID
ENC1	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
ENSA	Protein-peptide, Reconstituted Complex	physical	17893145, 18973346, (Europe PMC)	NA	BioGRID
FBXW7	Affinity Capture-Western	physical	26033182, (Europe PMC)	NA	BioGRID
FKBP4	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
FMR1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
FSD1	Affinity Capture-MS	physical	26186194, (Europe PMC)	NA	BioGRID
FXR1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
FXR2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
FYN	Biochemical Activity	physical	11078745, 11162638, 15033366, (Europe PMC)	NA	BioGRID
GABARAPL1	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
GAPDH	Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	15673432, 21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
GBA	Affinity Capture-Western, Reconstituted Complex	physical	21653695, 23266198, (Europe PMC)	NA	BioGRID
GRK1	Biochemical Activity	physical	10852916, (Europe PMC)	NA	BioGRID
GRK2	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
GRK5	Biochemical Activity	physical	10852916, (Europe PMC)	NA	BioGRID
GRK6	Biochemical Activity	physical	10852916, (Europe PMC)	NA	BioGRID
GSK3B	Reconstituted Complex, pull down	direct interaction, physical, physical association	21985244, (Europe PMC)	0.54	BioGRID, IntAct, MINT
HAX1	Affinity Capture-MS	physical	26186194, (Europe PMC)	NA	BioGRID
HCLS1	Affinity Capture-MS	physical	28514442, (Europe PMC)	NA	BioGRID
HERC5	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
HERPUD1	Affinity Capture-Western	physical	20604806, (Europe PMC)	NA	BioGRID
HIST2H3C	Affinity Capture-Western, Co-localization	physical	16959795, (Europe PMC)	NA	BioGRID
HK1	Affinity Capture-MS	physical	28514442, (Europe PMC)	NA	BioGRID
HPRT1	Co-fractionation	physical	22863883, (Europe PMC)	NA	BioGRID
HSD17B4	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
HSP90AA1	Reconstituted Complex	physical	19759002, (Europe PMC)	NA	BioGRID
HSPA1A	FRET, Reconstituted Complex	physical	19875982, (Europe PMC)	NA	BioGRID
HSPA1L	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
HSPA4	Affinity Capture-Western, Reconstituted Complex	physical	14711827, 17010992, 17012257, 21358815, 21832061, 21985244, (Europe PMC)	NA	BioGRID
HSPA8	Affinity Capture-Western, Protein-peptide, Reconstituted Complex	physical	17893145, 21832061, 22776201, 22843682, (Europe PMC)	NA	BioGRID
HSPB1	Affinity Capture-MS, Reconstituted Complex	physical	19651786, 21905118, (Europe PMC)	NA	BioGRID
HSPB2	Reconstituted Complex	physical	21905118, (Europe PMC)	NA	BioGRID
HSPB6	Reconstituted Complex	physical	21905118, (Europe PMC)	NA	BioGRID
HSPB8	Reconstituted Complex	physical	21905118, (Europe PMC)	NA	BioGRID
IARS	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
ILF3	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
KIAA1191	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
KLC1	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
KLK6	Biochemical Activity	physical	12928483, (Europe PMC)	NA	BioGRID
LAMP2	Affinity Capture-Western	physical	15333840, (Europe PMC)	NA	BioGRID
LAMTOR4	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
LCMT2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
LRRK2	Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy	colocalization, physical, physical association	19878656, 23183827, (Europe PMC)	0.56	BioGRID, IntAct
MAN2C1	Affinity Capture-MS	physical	28514442, (Europe PMC)	NA	BioGRID
MAP1B	Reconstituted Complex	physical	10764738, (Europe PMC)	NA	BioGRID
MAP1LC3A	Co-localization	physical	22411133, (Europe PMC)	NA	BioGRID
MAPK1	Affinity Capture-Western, Reconstituted Complex	physical	11279280, 12121974, (Europe PMC)	NA	BioGRID
MAPK3	Affinity Capture-Western	physical	12121974, (Europe PMC)	NA	BioGRID
MAPK8	Affinity Capture-Western	physical	12121974, (Europe PMC)	NA	BioGRID
MAPT	Affinity Capture-Western, Co-localization, Co-purification, Reconstituted Complex, pull down	direct interaction, physical, physical association	10464279, 15904919, 17408955, 21127069, 21985244, (Europe PMC)	0.54	BioGRID, IntAct, MINT
MCM5	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
MEF2D	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
MTREX	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
NCBP1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
NCBP2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
NDFIP1	Affinity Capture-Western	physical	27173227, (Europe PMC)	NA	BioGRID
NDUFB6	Affinity Capture-Western	physical	18614564, (Europe PMC)	NA	BioGRID
NEDD4	Affinity Capture-Western, Biochemical Activity	physical	21953697, 24831002, (Europe PMC)	NA	BioGRID
NEDD4L	Biochemical Activity	physical	24831002, (Europe PMC)	NA	BioGRID
NOS1AP	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
NUFIP1	Affinity Capture-MS	physical	26186194, (Europe PMC)	NA	BioGRID
P3H1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
PAK3	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
PARK7	Affinity Capture-Western	physical	15502874, 15935068, (Europe PMC)	NA	BioGRID
PATJ	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
PDE4DIP	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PDIA2	Reconstituted Complex	physical	27142583, (Europe PMC)	NA	BioGRID
PELP1	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
PFDN2	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
PIN1	Affinity Capture-Western, Co-localization	physical	16365047, (Europe PMC)	NA	BioGRID
PINK1	Affinity Capture-Western, Reconstituted Complex	physical	19167501, 27334109, (Europe PMC)	NA	BioGRID
PLCB2	Reconstituted Complex	physical	15641770, (Europe PMC)	NA	BioGRID
PLD1	Affinity Capture-Western, Reconstituted Complex	physical	11821392, (Europe PMC)	NA	BioGRID
PLK1	Biochemical Activity	physical	19889641, (Europe PMC)	NA	BioGRID
PLK2	Biochemical Activity	physical	19889641, 22988096, (Europe PMC)	NA	BioGRID
PLK3	Biochemical Activity	physical	19889641, (Europe PMC)	NA	BioGRID
POLR2H	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
POLR2L	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
PPIL3	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
PRDX1	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
PRDX3	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
PREP	PCA, Reconstituted Complex	physical	25555914, (Europe PMC)	NA	BioGRID
PRKCD	Affinity Capture-Western	physical	15978696, (Europe PMC)	NA	BioGRID
PRKN	Affinity Capture-MS, Affinity Capture-Western, Phenotypic Suppression	genetic, physical	11588587, 12670421, 12963044, 16714300, 18195004, 19651786, 25861987, (Europe PMC)	NA	BioGRID
PRPF19	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
PRSS1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
PSAP	Co-fractionation	physical	22939629, (Europe PMC)	NA	BioGRID
PSMC3	Affinity Capture-Western	physical	12551928, 15591046, (Europe PMC)	NA	BioGRID
RAB3A	Affinity Capture-Western	physical	15207266, 15854772, (Europe PMC)	NA	BioGRID
RAB5A	Affinity Capture-Western	physical	15207266, (Europe PMC)	NA	BioGRID
RAB8A	Affinity Capture-Western, fluorescence microscopy	colocalization, physical	15207266, 24983211, (Europe PMC)	0.27	BioGRID, IntAct
RABAC1	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, fluorescence microscopy, phage display, pull down	colocalization, direct interaction, physical, physical association	21798244, (Europe PMC)	0.63	BioGRID, IntAct
RALGDS	Affinity Capture-Western	physical	20448034, (Europe PMC)	NA	BioGRID
RNF10	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
RRAS2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
RREB1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SAP30BP	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
SDF4	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SEPT2	Affinity Capture-Western	physical	12695511, (Europe PMC)	NA	BioGRID
SEPT4	Affinity Capture-Western, Protein-peptide	physical	12695511, 17893145, (Europe PMC)	NA	BioGRID
SERPINB13	Affinity Capture-MS	physical	28514442, (Europe PMC)	NA	BioGRID
SGSM3	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
SIAH1	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	18065497, 18070888, 19224863, 27334109, (Europe PMC)	NA	BioGRID
SIAH2	Affinity Capture-Western, Biochemical Activity	physical	15064394, 18070888, 19224863, 22065755, (Europe PMC)	NA	BioGRID
SIN3A	Phenotypic Suppression	genetic	16959795, (Europe PMC)	NA	BioGRID
SLC6A2	Affinity Capture-Western	physical	17156375, 18331289, (Europe PMC)	NA	BioGRID
SLC6A3	Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, proximity ligation assay	association, physical, physical association	11292651, 12672538, 14550771, 14756560, 16216085, 22163275, (Europe PMC)	0.58	BioGRID, IntAct
SLC6A4	Affinity Capture-Western, Co-localization	physical	16882008, 19429025, (Europe PMC)	NA	BioGRID
SMU1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SNCA	Affinity Capture-MS, Affinity Capture-Western, Co-purification, FRET, PCA, Reconstituted Complex, atomic force microscopy, bimolecular fluorescence complementation, biophysical, circular dichroism, classical fluorescence spectroscopy, comigration in non denaturing gel electrophoresis, comigration in sds page, confocal microscopy, cosedimentation, cross-linking study, detection by mass spectrometry, dynamic light scattering, electron microscopy, electron tomography, fluorescence polarization spectroscopy, fluorescence technology, molecular sieving, nuclear magnetic resonance, proximity ligation assay, pull down, solid state nmr, transmission electron microscopy, x-ray fiber diffraction	association, colocalization, direct interaction, physical, physical association	11502187, 12928483, 15502874, 16330551, 16764865, 18055555, 18179253, 18221373, 18505736, 18550842, 18614564, 19651786, 19745811, 19875982, 20849899, 21358815, 21443877, 22119730, 23927048, 24374342, 24895406, 24983211, 25484190, 25555914, 25617759, 25643172, 25732184, 27018801, 27341336, (Europe PMC)	0.89, 0.98	BioGRID, IntAct, MINT
SNCAIP	Affinity Capture-Western, Co-crystal Structure, FRET, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, confocal microscopy, cross-linking study, fluorescence correlation spectroscopy, nuclear magnetic resonance, pull down, two hybrid	colocalization, direct interaction, physical, physical association	10319874, 11331421, 11742726, 12044636, 14645218, 15894486, 15944382, 16365047, 16595633, 19762560, 25861987, (Europe PMC)	0.52, 0.83	BioGRID, IntAct
SNCB	Affinity Capture-Western	physical	11683992, (Europe PMC)	NA	BioGRID
SNRNP200	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SPTBN1	Affinity Capture-Western, Co-localization, Reconstituted Complex, pull down	association, physical	18614564, 22771809, (Europe PMC)	0.35	BioGRID, IntAct
SQSTM1	Co-localization	physical	22411133, (Europe PMC)	NA	BioGRID
SRC	Biochemical Activity	physical	11078745, (Europe PMC)	NA	BioGRID
SRI	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
SRRM1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
SRRT	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SRSF4	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SSB	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
STUB1	Affinity Capture-Western, Biochemical Activity	physical	18436529, 21358815, (Europe PMC)	NA	BioGRID
SYN1	Protein-peptide, anti bait coimmunoprecipitation, proximity ligation assay	association, physical, physical association	17893145, 22163275, (Europe PMC)	0.50	BioGRID, IntAct
TAF7	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
TGM1	Biochemical Activity	physical	19651786, (Europe PMC)	NA	BioGRID
TGS1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
TMPRSS12	Affinity Capture-MS	physical	28514442, (Europe PMC)	NA	BioGRID
TOR1A	FRET	physical	11438481, (Europe PMC)	NA	BioGRID
TPPP	Affinity Capture-Western, imaging technique	colocalization, physical	17027006, 20849899, (Europe PMC)	0.27	BioGRID, IntAct, MINT
TRAF6	Affinity Capture-Western	physical	20634198, (Europe PMC)	NA	BioGRID
TUBA1B	Affinity Capture-MS, Affinity Capture-Western, Protein-peptide	physical	11698390, 16216085, 17893145, (Europe PMC)	NA	BioGRID
TUBB	Affinity Capture-MS	physical	11698390, (Europe PMC)	NA	BioGRID
TUBB1	Affinity Capture-Western	physical	16216085, (Europe PMC)	NA	BioGRID
TUBG1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
UBC	Affinity Capture-MS, FRET	physical	11603807, 19651786, (Europe PMC)	NA	BioGRID
UQCRC2	Affinity Capture-Western	physical	18614564, (Europe PMC)	NA	BioGRID
USP47	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
USP7	Biochemical Activity	physical	27444016, (Europe PMC)	NA	BioGRID
USP8	Affinity Capture-Western, Biochemical Activity, PCA	physical	27444016, (Europe PMC)	NA	BioGRID
USP9X	Affinity Capture-Western	physical	22065755, (Europe PMC)	NA	BioGRID
VDAC1	Affinity Capture-Western, pull down	association, physical	18614564, (Europe PMC)	0.35	BioGRID, IntAct
VDAC2	Affinity Capture-Western, pull down	association, physical	18614564, (Europe PMC)	0.35	BioGRID, IntAct
VIRMA	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
YWHAQ	Affinity Capture-Western	physical	15280438, (Europe PMC)	NA	BioGRID
ZCCHC8	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct

Visualize Download

Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
ABL1	anti bait coimmunoprecipitation, confocal microscopy, nuclear magnetic resonance, protein kinase assay	colocalization, phosphorylation reaction, physical association	24412932, (Europe PMC)	0.46, 0.56	IntAct
AKAP17A	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
APLP1	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
APP	Affinity Capture-Western, Co-localization, Reconstituted Complex, proximity ligation assay	physical, physical association	18769546, 21832049, 25241761, 7568089, 9163350, (Europe PMC)	0.40	BioGRID, IntAct
ATG5	anti tag coimmunoprecipitation	association	20417604, (Europe PMC)	0.35	IntAct
BAX	Co-localization, proximity ligation assay	physical, physical association	25241761, (Europe PMC)	0.40	BioGRID, IntAct
CDK4	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CEP295	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
CGRRF1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
CMBL	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
COL7A1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
CSNK1D	Biochemical Activity, Co-localization, proximity ligation assay	physical, physical association	16618118, 25241761, (Europe PMC)	0.40	BioGRID, IntAct
CSNK2A1	Biochemical Activity, protein kinase assay	phosphorylation reaction, physical	10617630, 15033366, 19576176, (Europe PMC)	0.44	BioGRID, IntAct
DHCR24	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
DOCK7	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DYNC1H1	Affinity Capture-MS, Protein-peptide, anti tag coimmunoprecipitation	association, physical	17893145, 26496610, (Europe PMC)	0.35	BioGRID, IntAct
DYNLL1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
EEF1A1	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
EFTUD2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
EGFR	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
EIF3G	two hybrid	physical association	21900206, (Europe PMC)	0.37	IntAct, MINT
FMR1	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
FXR2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
GAPDH	Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	15673432, 21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
GSK3B	Reconstituted Complex, pull down	direct interaction, physical, physical association	21985244, (Europe PMC)	0.54	BioGRID, IntAct, MINT
HERC5	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
HSPA1L	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
HTT	bimolecular fluorescence complementation, comigration in non denaturing gel electrophoresis, fluorescence microscopy	colocalization, physical association	22119730, (Europe PMC)	0.54	IntAct, MINT
ILF3	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
LAMTOR4	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
LCMT2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
LRRK2	Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy	colocalization, physical, physical association	19878656, 23183827, (Europe PMC)	0.56	BioGRID, IntAct
MAP1LC3B	anti tag coimmunoprecipitation	association	20417604, (Europe PMC)	0.35	IntAct
MAPT	Affinity Capture-Western, Co-localization, Co-purification, Reconstituted Complex, pull down	direct interaction, physical, physical association	10464279, 15904919, 17408955, 21127069, 21985244, (Europe PMC)	0.54	BioGRID, IntAct, MINT
MCM5	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
MT-CO3	anti tag coimmunoprecipitation, two hybrid	physical association	12059041, (Europe PMC)	0.51	IntAct
MTREX	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
NCBP1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
NCBP2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
NOS1AP	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
P3H1	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
PARK7	anti tag coimmunoprecipitation	physical association	15502874, (Europe PMC)	0.40	IntAct
PATJ	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
PDE4DIP	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
POLR2L	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
PPIL3	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
PRDX3	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
PRPF19	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
RAB8A	Affinity Capture-Western, fluorescence microscopy	colocalization, physical	15207266, 24983211, (Europe PMC)	0.27	BioGRID, IntAct
RABAC1	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, fluorescence microscopy, phage display, pull down	colocalization, direct interaction, physical, physical association	21798244, (Europe PMC)	0.63	BioGRID, IntAct
RRAS2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
RREB1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SDF4	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SLC6A3	Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, proximity ligation assay	association, physical, physical association	11292651, 12672538, 14550771, 14756560, 16216085, 22163275, (Europe PMC)	0.58	BioGRID, IntAct
SMU1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SNCA	Affinity Capture-MS, Affinity Capture-Western, Co-purification, FRET, PCA, Reconstituted Complex, atomic force microscopy, bimolecular fluorescence complementation, biophysical, circular dichroism, classical fluorescence spectroscopy, comigration in non denaturing gel electrophoresis, comigration in sds page, confocal microscopy, cosedimentation, cross-linking study, detection by mass spectrometry, dynamic light scattering, electron microscopy, electron tomography, fluorescence polarization spectroscopy, fluorescence technology, molecular sieving, nuclear magnetic resonance, proximity ligation assay, pull down, solid state nmr, transmission electron microscopy, x-ray fiber diffraction	association, colocalization, direct interaction, physical, physical association	11502187, 12928483, 15502874, 16330551, 16764865, 18055555, 18179253, 18221373, 18505736, 18550842, 18614564, 19651786, 19745811, 19875982, 20849899, 21358815, 21443877, 22119730, 23927048, 24374342, 24895406, 24983211, 25484190, 25555914, 25617759, 25643172, 25732184, 27018801, 27341336, (Europe PMC)	0.89, 0.98	BioGRID, IntAct, MINT
SNCAIP	Affinity Capture-Western, Co-crystal Structure, FRET, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, confocal microscopy, cross-linking study, fluorescence correlation spectroscopy, nuclear magnetic resonance, pull down, two hybrid	colocalization, direct interaction, physical, physical association	10319874, 11331421, 11742726, 12044636, 14645218, 15894486, 15944382, 16365047, 16595633, 19762560, 25861987, (Europe PMC)	0.52, 0.83	BioGRID, IntAct
SNRNP200	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SPTBN1	Affinity Capture-Western, Co-localization, Reconstituted Complex, pull down	association, physical	18614564, 22771809, (Europe PMC)	0.35	BioGRID, IntAct
SRRT	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SRSF4	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SSB	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SYN1	Protein-peptide, anti bait coimmunoprecipitation, proximity ligation assay	association, physical, physical association	17893145, 22163275, (Europe PMC)	0.50	BioGRID, IntAct
TAF7	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
TGS1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
TPPP	Affinity Capture-Western, imaging technique	colocalization, physical	17027006, 20849899, (Europe PMC)	0.27	BioGRID, IntAct, MINT
TUBG1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
VDAC1	Affinity Capture-Western, pull down	association, physical	18614564, (Europe PMC)	0.35	BioGRID, IntAct
VDAC2	Affinity Capture-Western, pull down	association, physical	18614564, (Europe PMC)	0.35	BioGRID, IntAct
VIM	fluorescence microscopy	colocalization	16678164, (Europe PMC)	0.27	IntAct, MINT
VIRMA	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
WDFY3	anti tag coimmunoprecipitation	association	20417604, (Europe PMC)	0.35	IntAct
YWHAH	atomic force microscopy, circular dichroism, confocal microscopy, electrophoretic mobility-based method, fluorescence polarization spectroscopy, transmission electron microscopy	colocalization, direct interaction, physical association	24895406, (Europe PMC)	0.27, 0.64	IntAct
ZCCHC8	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct

Visualize Download

Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
APLP1	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CDK4	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DOCK7	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
EEF1A1	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
EIF3G	two hybrid	physical association	21900206, (Europe PMC)	0.37	IntAct, MINT
GAPDH	Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	15673432, 21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
GSK3B	Reconstituted Complex, pull down	direct interaction, physical, physical association	21985244, (Europe PMC)	0.54	BioGRID, IntAct, MINT
HTT	bimolecular fluorescence complementation, comigration in non denaturing gel electrophoresis, fluorescence microscopy	colocalization, physical association	22119730, (Europe PMC)	0.54	IntAct, MINT
MAPT	Affinity Capture-Western, Co-localization, Co-purification, Reconstituted Complex, pull down	direct interaction, physical, physical association	10464279, 15904919, 17408955, 21127069, 21985244, (Europe PMC)	0.54	BioGRID, IntAct, MINT
PDE4DIP	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SDF4	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SNCA	Affinity Capture-MS, Affinity Capture-Western, Co-purification, FRET, PCA, Reconstituted Complex, atomic force microscopy, bimolecular fluorescence complementation, biophysical, circular dichroism, classical fluorescence spectroscopy, comigration in non denaturing gel electrophoresis, comigration in sds page, confocal microscopy, cosedimentation, cross-linking study, detection by mass spectrometry, dynamic light scattering, electron microscopy, electron tomography, fluorescence polarization spectroscopy, fluorescence technology, molecular sieving, nuclear magnetic resonance, proximity ligation assay, pull down, solid state nmr, transmission electron microscopy, x-ray fiber diffraction	association, colocalization, direct interaction, physical, physical association	11502187, 12928483, 15502874, 16330551, 16764865, 18055555, 18179253, 18221373, 18505736, 18550842, 18614564, 19651786, 19745811, 19875982, 20849899, 21358815, 21443877, 22119730, 23927048, 24374342, 24895406, 24983211, 25484190, 25555914, 25617759, 25643172, 25732184, 27018801, 27341336, (Europe PMC)	0.89, 0.98	BioGRID, IntAct, MINT
TPPP	Affinity Capture-Western, imaging technique	colocalization, physical	17027006, 20849899, (Europe PMC)	0.27	BioGRID, IntAct, MINT
VIM	fluorescence microscopy	colocalization	16678164, (Europe PMC)	0.27	IntAct, MINT

Visualize Download

Interacting partner	Detection method	Interaction type	PubMed IDs	Interaction Score	Source
ABL1	anti bait coimmunoprecipitation, confocal microscopy, nuclear magnetic resonance, protein kinase assay	colocalization, phosphorylation reaction, physical association	24412932, (Europe PMC)	0.46, 0.56	IntAct
ACTA1	Reconstituted Complex	physical	19553474, (Europe PMC)	NA	BioGRID
ACTB	Affinity Capture-Western	physical	18331289, (Europe PMC)	NA	BioGRID
ADAP2	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
AKAP17A	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
AKT1	Affinity Capture-Western, Far Western	physical	21474915, (Europe PMC)	NA	BioGRID
ANXA6	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
AP1B1	Affinity Capture-Western	physical	18614564, (Europe PMC)	NA	BioGRID
APLP1	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
APP	Affinity Capture-Western, Co-localization, Reconstituted Complex, proximity ligation assay	physical, physical association	18769546, 21832049, 25241761, 7568089, 9163350, (Europe PMC)	0.40	BioGRID, IntAct
ARHGAP15	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
ARPP19	Reconstituted Complex	physical	17893145, (Europe PMC)	NA	BioGRID
ARRB1	Affinity Capture-Western	physical	20448034, (Europe PMC)	NA	BioGRID
ATG5	anti tag coimmunoprecipitation	association	20417604, (Europe PMC)	0.35	IntAct
BAD	Affinity Capture-Western	physical	15978696, (Europe PMC)	NA	BioGRID
BAG5	Affinity Capture-Western, Reconstituted Complex	physical	21358815, (Europe PMC)	NA	BioGRID
BAX	Co-localization, proximity ligation assay	physical, physical association	25241761, (Europe PMC)	0.40	BioGRID, IntAct
BDH2	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
CALM1	Affinity Capture-Western, Reconstituted Complex	physical	12358748, 12610000, (Europe PMC)	NA	BioGRID
CAV1	Reconstituted Complex	physical	21693152, (Europe PMC)	NA	BioGRID
CBX4	Affinity Capture-Western	physical	21256122, (Europe PMC)	NA	BioGRID
CDC42EP2	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
CDC42EP3	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
CDC42SE1	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
CDK4	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
CEP295	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
CEP295	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
CGRRF1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
CHMP5	Co-fractionation	physical	22863883, (Europe PMC)	NA	BioGRID
CLTC	Affinity Capture-Western	physical	18614564, (Europe PMC)	NA	BioGRID
CMBL	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
COL7A1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
COX1	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
CRYAB	Co-crystal Structure, Co-fractionation, Reconstituted Complex	physical	15236975, 20197038, 21905118, (Europe PMC)	NA	BioGRID
CSNK1A1	Biochemical Activity	physical	10617630, 16959772, (Europe PMC)	NA	BioGRID
CSNK1D	Biochemical Activity, Co-localization, proximity ligation assay	physical, physical association	16618118, 25241761, (Europe PMC)	0.40	BioGRID, IntAct
CSNK2A1	Biochemical Activity, protein kinase assay	phosphorylation reaction, physical	10617630, 15033366, 19576176, (Europe PMC)	0.44	BioGRID, IntAct
CTNND1	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
CTSD	Biochemical Activity	physical	25617759, (Europe PMC)	NA	BioGRID
DGUOK	Affinity Capture-MS	physical	26186194, (Europe PMC)	NA	BioGRID
DHCR24	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
DMTN	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
DNAAF2	Affinity Capture-MS	physical	26186194, 28514442, (Europe PMC)	NA	BioGRID
DNAJB1	Affinity Capture-Western	physical	17012257, (Europe PMC)	NA	BioGRID
DOCK7	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
DYNC1H1	Affinity Capture-MS, Protein-peptide, anti tag coimmunoprecipitation	association, physical	17893145, 26496610, (Europe PMC)	0.35	BioGRID, IntAct
DYNLL1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
DYRK1A	Affinity Capture-Western, Biochemical Activity	physical	16959772, (Europe PMC)	NA	BioGRID
EEF1A1	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
EFTUD2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
EGFR	Affinity Capture-Luminescence, PCA, Two-hybrid, ubiquitin reconstruction	physical, physical association	24658140, 25402006, (Europe PMC)	0.37	BioGRID, IntAct
EIF3G	Two-hybrid	physical	21900206, (Europe PMC)	NA	BioGRID
EIF3G	two hybrid	physical association	21900206, (Europe PMC)	0.37	IntAct, MINT
ELK1	Affinity Capture-Western	physical	11279280, (Europe PMC)	NA	BioGRID
ENC1	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
ENSA	Protein-peptide, Reconstituted Complex	physical	17893145, 18973346, (Europe PMC)	NA	BioGRID
FBXW7	Affinity Capture-Western	physical	26033182, (Europe PMC)	NA	BioGRID
FKBP4	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
FMR1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
FMR1	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
FSD1	Affinity Capture-MS	physical	26186194, (Europe PMC)	NA	BioGRID
FXR1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
FXR2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
FYN	Biochemical Activity	physical	11078745, 11162638, 15033366, (Europe PMC)	NA	BioGRID
GABARAPL1	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
GAPDH	Reconstituted Complex, Two-hybrid, two hybrid	physical, physical association	15673432, 21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
GBA	Affinity Capture-Western, Reconstituted Complex	physical	21653695, 23266198, (Europe PMC)	NA	BioGRID
GRK1	Biochemical Activity	physical	10852916, (Europe PMC)	NA	BioGRID
GRK2	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
GRK5	Biochemical Activity	physical	10852916, (Europe PMC)	NA	BioGRID
GRK6	Biochemical Activity	physical	10852916, (Europe PMC)	NA	BioGRID
GSK3B	Reconstituted Complex, pull down	direct interaction, physical, physical association	21985244, (Europe PMC)	0.54	BioGRID, IntAct, MINT
HAX1	Affinity Capture-MS	physical	26186194, (Europe PMC)	NA	BioGRID
HCLS1	Affinity Capture-MS	physical	28514442, (Europe PMC)	NA	BioGRID
HERC5	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
HERPUD1	Affinity Capture-Western	physical	20604806, (Europe PMC)	NA	BioGRID
HIST2H3C	Affinity Capture-Western, Co-localization	physical	16959795, (Europe PMC)	NA	BioGRID
HK1	Affinity Capture-MS	physical	28514442, (Europe PMC)	NA	BioGRID
HPRT1	Co-fractionation	physical	22863883, (Europe PMC)	NA	BioGRID
HSD17B4	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
HSP90AA1	Reconstituted Complex	physical	19759002, (Europe PMC)	NA	BioGRID
HSPA1A	FRET, Reconstituted Complex	physical	19875982, (Europe PMC)	NA	BioGRID
HSPA1L	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
HSPA4	Affinity Capture-Western, Reconstituted Complex	physical	14711827, 17010992, 17012257, 21358815, 21832061, 21985244, (Europe PMC)	NA	BioGRID
HSPA8	Affinity Capture-Western, Protein-peptide, Reconstituted Complex	physical	17893145, 21832061, 22776201, 22843682, (Europe PMC)	NA	BioGRID
HSPB1	Affinity Capture-MS, Reconstituted Complex	physical	19651786, 21905118, (Europe PMC)	NA	BioGRID
HSPB2	Reconstituted Complex	physical	21905118, (Europe PMC)	NA	BioGRID
HSPB6	Reconstituted Complex	physical	21905118, (Europe PMC)	NA	BioGRID
HSPB8	Reconstituted Complex	physical	21905118, (Europe PMC)	NA	BioGRID
HTT	bimolecular fluorescence complementation, comigration in non denaturing gel electrophoresis, fluorescence microscopy	colocalization, physical association	22119730, (Europe PMC)	0.54	IntAct, MINT
IARS	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
ILF3	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
KIAA1191	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
KLC1	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
KLK6	Biochemical Activity	physical	12928483, (Europe PMC)	NA	BioGRID
LAMP2	Affinity Capture-Western	physical	15333840, (Europe PMC)	NA	BioGRID
LAMTOR4	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
LCMT2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
LRRK2	Affinity Capture-Western, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy	colocalization, physical, physical association	19878656, 23183827, (Europe PMC)	0.56	BioGRID, IntAct
MAN2C1	Affinity Capture-MS	physical	28514442, (Europe PMC)	NA	BioGRID
MAP1B	Reconstituted Complex	physical	10764738, (Europe PMC)	NA	BioGRID
MAP1LC3A	Co-localization	physical	22411133, (Europe PMC)	NA	BioGRID
MAP1LC3B	anti tag coimmunoprecipitation	association	20417604, (Europe PMC)	0.35	IntAct
MAPK1	Affinity Capture-Western, Reconstituted Complex	physical	11279280, 12121974, (Europe PMC)	NA	BioGRID
MAPK3	Affinity Capture-Western	physical	12121974, (Europe PMC)	NA	BioGRID
MAPK8	Affinity Capture-Western	physical	12121974, (Europe PMC)	NA	BioGRID
MAPT	Affinity Capture-Western, Co-localization, Co-purification, Reconstituted Complex, pull down	direct interaction, physical, physical association	10464279, 15904919, 17408955, 21127069, 21985244, (Europe PMC)	0.54	BioGRID, IntAct, MINT
MCM5	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
MEF2D	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
MT-CO3	anti tag coimmunoprecipitation, two hybrid	physical association	12059041, (Europe PMC)	0.51	IntAct
MTREX	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
MTREX	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
NCBP1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
NCBP2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
NDFIP1	Affinity Capture-Western	physical	27173227, (Europe PMC)	NA	BioGRID
NDUFB6	Affinity Capture-Western	physical	18614564, (Europe PMC)	NA	BioGRID
NEDD4	Affinity Capture-Western, Biochemical Activity	physical	21953697, 24831002, (Europe PMC)	NA	BioGRID
NEDD4L	Biochemical Activity	physical	24831002, (Europe PMC)	NA	BioGRID
NOS1AP	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
NUFIP1	Affinity Capture-MS	physical	26186194, (Europe PMC)	NA	BioGRID
P3H1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
P3H1	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
PAK3	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
PARK7	Affinity Capture-Western	physical	15502874, 15935068, (Europe PMC)	NA	BioGRID
PARK7	anti tag coimmunoprecipitation	physical association	15502874, (Europe PMC)	0.40	IntAct
PATJ	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
PATJ	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
PDE4DIP	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
PDIA2	Reconstituted Complex	physical	27142583, (Europe PMC)	NA	BioGRID
PELP1	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
PFDN2	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
PIN1	Affinity Capture-Western, Co-localization	physical	16365047, (Europe PMC)	NA	BioGRID
PINK1	Affinity Capture-Western, Reconstituted Complex	physical	19167501, 27334109, (Europe PMC)	NA	BioGRID
PLCB2	Reconstituted Complex	physical	15641770, (Europe PMC)	NA	BioGRID
PLD1	Affinity Capture-Western, Reconstituted Complex	physical	11821392, (Europe PMC)	NA	BioGRID
PLK1	Biochemical Activity	physical	19889641, (Europe PMC)	NA	BioGRID
PLK2	Biochemical Activity	physical	19889641, 22988096, (Europe PMC)	NA	BioGRID
PLK3	Biochemical Activity	physical	19889641, (Europe PMC)	NA	BioGRID
POLR2H	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
POLR2L	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
PPIL3	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
PRDX1	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
PRDX3	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
PREP	PCA, Reconstituted Complex	physical	25555914, (Europe PMC)	NA	BioGRID
PRKCD	Affinity Capture-Western	physical	15978696, (Europe PMC)	NA	BioGRID
PRKN	Affinity Capture-MS, Affinity Capture-Western, Phenotypic Suppression	genetic, physical	11588587, 12670421, 12963044, 16714300, 18195004, 19651786, 25861987, (Europe PMC)	NA	BioGRID
PRPF19	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
PRPF19	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
PRSS1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
PSAP	Co-fractionation	physical	22939629, (Europe PMC)	NA	BioGRID
PSMC3	Affinity Capture-Western	physical	12551928, 15591046, (Europe PMC)	NA	BioGRID
RAB3A	Affinity Capture-Western	physical	15207266, 15854772, (Europe PMC)	NA	BioGRID
RAB5A	Affinity Capture-Western	physical	15207266, (Europe PMC)	NA	BioGRID
RAB8A	Affinity Capture-Western, fluorescence microscopy	colocalization, physical	15207266, 24983211, (Europe PMC)	0.27	BioGRID, IntAct
RABAC1	Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation, fluorescence microscopy, phage display, pull down	colocalization, direct interaction, physical, physical association	21798244, (Europe PMC)	0.63	BioGRID, IntAct
RALGDS	Affinity Capture-Western	physical	20448034, (Europe PMC)	NA	BioGRID
RNF10	Reconstituted Complex	physical	18541383, (Europe PMC)	NA	BioGRID
RRAS2	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
RREB1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SAP30BP	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
SDF4	Two-hybrid, two hybrid	physical, physical association	21900206, (Europe PMC)	0.37	BioGRID, IntAct, MINT
SEPT2	Affinity Capture-Western	physical	12695511, (Europe PMC)	NA	BioGRID
SEPT4	Affinity Capture-Western, Protein-peptide	physical	12695511, 17893145, (Europe PMC)	NA	BioGRID
SERPINB13	Affinity Capture-MS	physical	28514442, (Europe PMC)	NA	BioGRID
SGSM3	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
SIAH1	Affinity Capture-Western, Biochemical Activity, Reconstituted Complex	physical	18065497, 18070888, 19224863, 27334109, (Europe PMC)	NA	BioGRID
SIAH2	Affinity Capture-Western, Biochemical Activity	physical	15064394, 18070888, 19224863, 22065755, (Europe PMC)	NA	BioGRID
SIN3A	Phenotypic Suppression	genetic	16959795, (Europe PMC)	NA	BioGRID
SLC6A2	Affinity Capture-Western	physical	17156375, 18331289, (Europe PMC)	NA	BioGRID
SLC6A3	Affinity Capture-Western, Two-hybrid, anti bait coimmunoprecipitation, proximity ligation assay	association, physical, physical association	11292651, 12672538, 14550771, 14756560, 16216085, 22163275, (Europe PMC)	0.58	BioGRID, IntAct
SLC6A4	Affinity Capture-Western, Co-localization	physical	16882008, 19429025, (Europe PMC)	NA	BioGRID
SMU1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SNCA	Affinity Capture-MS, Affinity Capture-Western, Co-purification, FRET, PCA, Reconstituted Complex, atomic force microscopy, bimolecular fluorescence complementation, biophysical, circular dichroism, classical fluorescence spectroscopy, comigration in non denaturing gel electrophoresis, comigration in sds page, confocal microscopy, cosedimentation, cross-linking study, detection by mass spectrometry, dynamic light scattering, electron microscopy, electron tomography, fluorescence polarization spectroscopy, fluorescence technology, molecular sieving, nuclear magnetic resonance, proximity ligation assay, pull down, solid state nmr, transmission electron microscopy, x-ray fiber diffraction	association, colocalization, direct interaction, physical, physical association	11502187, 12928483, 15502874, 16330551, 16764865, 18055555, 18179253, 18221373, 18505736, 18550842, 18614564, 19651786, 19745811, 19875982, 20849899, 21358815, 21443877, 22119730, 23927048, 24374342, 24895406, 24983211, 25484190, 25555914, 25617759, 25643172, 25732184, 27018801, 27341336, (Europe PMC)	0.89, 0.98	BioGRID, IntAct, MINT
SNCAIP	Affinity Capture-Western, Co-crystal Structure, FRET, Reconstituted Complex, Two-hybrid, anti tag coimmunoprecipitation, confocal microscopy, cross-linking study, fluorescence correlation spectroscopy, nuclear magnetic resonance, pull down, two hybrid	colocalization, direct interaction, physical, physical association	10319874, 11331421, 11742726, 12044636, 14645218, 15894486, 15944382, 16365047, 16595633, 19762560, 25861987, (Europe PMC)	0.52, 0.83	BioGRID, IntAct
SNCB	Affinity Capture-Western	physical	11683992, (Europe PMC)	NA	BioGRID
SNRNP200	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SPTBN1	Affinity Capture-Western, Co-localization, Reconstituted Complex, pull down	association, physical	18614564, 22771809, (Europe PMC)	0.35	BioGRID, IntAct
SQSTM1	Co-localization	physical	22411133, (Europe PMC)	NA	BioGRID
SRC	Biochemical Activity	physical	11078745, (Europe PMC)	NA	BioGRID
SRI	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
SRRM1	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
SRRT	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SRSF4	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
SSB	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
STUB1	Affinity Capture-Western, Biochemical Activity	physical	18436529, 21358815, (Europe PMC)	NA	BioGRID
SYN1	Protein-peptide, anti bait coimmunoprecipitation, proximity ligation assay	association, physical, physical association	17893145, 22163275, (Europe PMC)	0.50	BioGRID, IntAct
TAF7	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
TGM1	Biochemical Activity	physical	19651786, (Europe PMC)	NA	BioGRID
TGS1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
TMPRSS12	Affinity Capture-MS	physical	28514442, (Europe PMC)	NA	BioGRID
TOR1A	FRET	physical	11438481, (Europe PMC)	NA	BioGRID
TPPP	Affinity Capture-Western, imaging technique	colocalization, physical	17027006, 20849899, (Europe PMC)	0.27	BioGRID, IntAct, MINT
TRAF6	Affinity Capture-Western	physical	20634198, (Europe PMC)	NA	BioGRID
TUBA1B	Affinity Capture-MS, Affinity Capture-Western, Protein-peptide	physical	11698390, 16216085, 17893145, (Europe PMC)	NA	BioGRID
TUBB	Affinity Capture-MS	physical	11698390, (Europe PMC)	NA	BioGRID
TUBB1	Affinity Capture-Western	physical	16216085, (Europe PMC)	NA	BioGRID
TUBG1	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct
UBC	Affinity Capture-MS, FRET	physical	11603807, 19651786, (Europe PMC)	NA	BioGRID
UQCRC2	Affinity Capture-Western	physical	18614564, (Europe PMC)	NA	BioGRID
USP47	Protein-peptide	physical	17893145, (Europe PMC)	NA	BioGRID
USP7	Biochemical Activity	physical	27444016, (Europe PMC)	NA	BioGRID
USP8	Affinity Capture-Western, Biochemical Activity, PCA	physical	27444016, (Europe PMC)	NA	BioGRID
USP9X	Affinity Capture-Western	physical	22065755, (Europe PMC)	NA	BioGRID
VDAC1	Affinity Capture-Western, pull down	association, physical	18614564, (Europe PMC)	0.35	BioGRID, IntAct
VDAC2	Affinity Capture-Western, pull down	association, physical	18614564, (Europe PMC)	0.35	BioGRID, IntAct
VIM	fluorescence microscopy	colocalization	16678164, (Europe PMC)	0.27	IntAct, MINT
VIRMA	Affinity Capture-MS	physical	26496610, (Europe PMC)	NA	BioGRID
VIRMA	anti tag coimmunoprecipitation	association	26496610, (Europe PMC)	0.35	IntAct
WDFY3	anti tag coimmunoprecipitation	association	20417604, (Europe PMC)	0.35	IntAct
YWHAH	atomic force microscopy, circular dichroism, confocal microscopy, electrophoretic mobility-based method, fluorescence polarization spectroscopy, transmission electron microscopy	colocalization, direct interaction, physical association	24895406, (Europe PMC)	0.27, 0.64	IntAct
YWHAQ	Affinity Capture-Western	physical	15280438, (Europe PMC)	NA	BioGRID
ZCCHC8	Affinity Capture-MS, anti tag coimmunoprecipitation	association, physical	26496610, (Europe PMC)	0.35	BioGRID, IntAct

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SNCA