Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - Alzheimer disease - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| PPP3CB | P16298 | DNM1L, CRYAA, HSPB1, JUN, MAPT, NEFH, PRKAR2A, ELK1, FLNA, CANX, CSNK1E, GSK3B, VASP, DNM2, RCAN1, DNM1, GAD2, NFATC2, PPP1R1A, SLC10A1, KSR2, SSH1, BAD, GAD1, PPP1R1B, TFEB, NFKBIA, LASP1, | Non-protein substrates of this phosphatase are not reported yet |
| PPP3CC | P48454 | DNM1L, CRYAA, HSPB1, JUN, MAPT, NEFH, PRKAR2A, ELK1, FLNA, CANX, CSNK1E, GSK3B, VASP, DNM2, RCAN1, DNM1, GAD2, NFATC2, PPP1R1A, SLC10A1, KSR2, SSH1, BAD, GAD1, PPP1R1B, TFEB, NFKBIA, LASP1, | Non-protein substrates of this phosphatase are not reported yet |
| PPP3CA | Q08209 | DNM1L, CRYAA, HSPB1, JUN, MAPT, NEFH, PRKAR2A, ELK1, FLNA, CANX, CSNK1E, GSK3B, VASP, DNM2, RCAN1, DNM1, GAD2, NFATC2, PPP1R1A, SLC10A1, KSR2, SSH1, BAD, GAD1, PPP1R1B, TFEB, NFKBIA, LASP1, TRPM3, ORAI1, | Non-protein substrates of this phosphatase are not reported yet |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| MAPT | P10636 | PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPP3CA, PPP3CB, PPP3CC, PPP5C, |
| MAPK3 | P27361 | CDC25A, DUPD1, PTPN7, DUSP5, DUSP1, DUSP4, DUSP9, DUSP23, PTPRE, PTPRJ, DUSP3, PPP2CA, PTPRR, DUSP14, |
| MAPK1 | P28482 | CDC25A, DUSP22, DUPD1, PTPN7, DUSP5, DUSP1, DUSP4, DUSP6, DUSP9, DUSP7, DUSP2, PPP2CA, PPP2CB, PTPRE, PTPRJ, DUSP3, PTPRR, |
| NOS1 | P29475 | PTPN6, |
| SNCA | P37840 | PPP2CA, PPP2CB, |
| CASP3 | P42574 | PPP2CA, PPP2CB, |
| GSK3B | P49841 | EPM2A, PPP3CA, PPP3CB, PPP3CC, PTPN1, |
| CASP9 | P55211 | PPP1CA, |
| CASP8 | Q14790 | PTPN6, |
| CDK5R1 | Q15078 | PPP2CA, PPP2CB, |
| BAD | Q92934 | ALPL, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPP3CA, PPP3CB, PPP3CC, PPM1B, PPP5C, |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:16595 | C01245 | 1D-myo-inositol 1,4,5-trisphosphate |  | INPP5B, INPP5A, INPP5E, INPP5J, INPP5K, OCRL, SYNJ1, SYNJ2, |