Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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INPP5J
Gene Name  | INPP5J (QuickGO) | (A quick tutorial to explore the interctive visulaization) |
| Synonyms | INPP5J, PIB5PA, PIPP | |
| Protein Name | INPP5J |
|
| Alternative Name(s) |
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A;3.1.3.56;Inositol polyphosphate 5-phosphatase J; | |
| EntrezGene ID | 27124 (Comparitive Toxicogenomics) | |
| UniProt AC (Human) | Q15735 (protein sequence) | |
| Enzyme Class | EC 3.1.3.56 (BRENDA ) | |
| Molecular Weight | 107197 Dalton | |
| Protein Length | 1006 amino acids (AA) | |
| Genome Browsers | NCBI | ENSG00000185133 (Ensembl) | UCSC | |
| Crosslinking annotations | Query our ID-mapping table | |
| Orthologues | Quest For Orthologues (QFO) | GeneTree | |
| Classification | Superfamily: inositol-5-phosphatases (IP) | Historic class: Inositol-1,4,5-trisphosphate 5-phosphatase | CATH ID: 3.60.10.10 | SCOP Fold: DNase I | |
| Phosphatase activity | active | Catalytic signature motif: unknown | |
| Phosphorylation Network | Visualize | |
| Domain organization, Expression, Diseases | (show / hide) |
| Protein Domain | InterPro | Pfam | SMART | 3D Structure | PDB | DrugPort | ModBase | SwissModel |
| Polypeptide organization (Pfam) | No Pfam domain found | ||
| Catalytic Site | Mechanism and Catalytic Site Atlas | ||
| Gene Expression | Gene Expression Atlas | Diseases | OMIM | DisGeNet | ClinVar |
| Protein-protein interactions | STRING | IntAct | MINT | BioGRID | ||
| Phosphosites | Phospho.ELM | PhosphoSitePlus | ||
| Localization, Function, Catalytic activity and Sequence | (show / hide) |
| Localization (UniProt annotation) | |||
| Cytoplasm Note=Predominantlylocalized to membrane ruffles | |||
| Function (UniProt annotation) | |||
| Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate Also convertsphosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol1,3,4-trisphosphate in vitro May be involved in modulation of thefunction of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (Bysimilarity) | |||
| Catalytic Activity (UniProt annotation) | |||
| D-myo-inositol 1,4,5-trisphosphate + H(2)O =myo-inositol 1,4-bisphosphate + phosphate 1D-myo-inositol 1,3,4,5-tetrakisphosphate +H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate | |||
| Protein Sequence | |||
| MEGQSSRGSRRPGTRAGLGSLPMPQGVAQTGAPSKVDSSFQLPAKKNAALGPSEPRLALAPVGPRAAMSASSEGPRLALA SPRPILAPLCTPEGQKTATAHRSSSLAPTSVGQLVMSASAGPKPPPATTGSVLAPTSLGLVMPASAGPRSPPVTLGPNLA PTSRDQKQEPPASVGPKPTLAASGLSLALASEEQPPELPSTPSPVPSPVLSPTQEQALAPASTASGAASVGQTSARKRDA PAPRPLPASEGHLQPPAQTSGPTGSPPCIQTSPDPRLSPSFRARPEALHSSPEDPVLPRPPQTLPLDVGQGPSEPGTHSP GLLSPTFRPGAPSGQTVPPPLPKPPRSPSRSPSHSPNRSPCVPPAPDMALPRLGTQSTGPGRCLSPNLQAQEAPAPVTTS SSTSTLSSSPWSAQPTWKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGGGDDSDGADMIAIGLQEVNSMLNKRLKDALFT DQWSELFMDALGPFNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCH LPAHMDKAEQRKDNFQTILSLQQFQGPGAQGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNT WPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYTVSD HKPVAAQFLLQFAFRDDMPLVRLEVADEWVRPEQAVVRYRMETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEDVDGN TYQVTFSEESLPKGHGDFILGYYSHNHSILIGITEPFQISLPSSELASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGK SKRHRSRSPGLARFPGLALRPSSRERRGASRSPSPQSRRLSRVAPDRSSNGSSRGSSEEGPSGLPGPWAFPPAVPRSLGL LPALRLETVDPGGGGSWGPDREALAPNSLSPSPQGHRGLEEGGLGP |
| Motif information from Eukaryotic Linear Motif atlas (ELM) | (show / hide) |
ELM Motif | Motif Instance | Description | Motif Regex |
| NA | NA | NA | NA |
| Gene Ontology (P: Process; F: Function and C: Component terms) | (show / hide) | |
| GO:0001726 | C:ruffle |
| GO:0004439 | F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity |
| GO:0004445 | F:inositol-polyphosphate 5-phosphatase activity |
| GO:0005737 | C:cytoplasm |
| GO:0005829 | C:cytosol |
| GO:0005886 | C:plasma membrane |
| GO:0006661 | P:phosphatidylinositol biosynthetic process |
| GO:0010977 | P:negative regulation of neuron projection development |
| GO:0017124 | F:SH3 domain binding |
| GO:0030426 | C:growth cone |
| GO:0031115 | P:negative regulation of microtubule polymerization |
| GO:0033137 | P:negative regulation of peptidyl-serine phosphorylation |
| GO:0034485 | F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity |
| GO:0043198 | C:dendritic shaft |
| GO:0043647 | P:inositol phosphate metabolic process |
| GO:0046856 | P:phosphatidylinositol dephosphorylation |
| GO:0052658 | F:inositol-1,4,5-trisphosphate 5-phosphatase activity |
| GO:0052659 | F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity |
