Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
299 KEGG pathways;
876 Reactome pathways;
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023




Gene Name CASP8 (QuickGO)
Interactive visualization of CASP8 structures
(A quick tutorial to explore the interctive visulaization)

Representative structure: 3H11

SynonymsCASP8, MCH5
Protein NameCASP8
Alternative Name(s)
Caspase-8;CASP-8;;Apoptotic cysteine protease;Apoptotic protease Mch-5;CAP4;FADD-homologous ICE/ced-3-like protease;FADD-like ICE;FLICE;ICE-like apoptotic protease 5;MORT1-associated ced-3 homolog;MACH;Caspase-8 subunit p18;Caspase-8 subunit p10;
Protein FamilyBelongs to the peptidase C14A family
EntrezGene ID841   (Comparitive Toxicogenomics)
UniProt AC (Human)Q14790 (protein sequence)
Enzyme Class3.4.22.61 (BRENDA )
Molecular Weight55391 Dalton
Protein Length479 amino acids (AA)
Genome Browsers NCBI | ENSG00000064012 (Ensembl) | UCSC
Crosslinking annotations Query our ID-mapping table
Orthologues Quest For Orthologues (QFO) | GeneTree | eggNOG - KOG3573 | eggNOG - ENOG410ZQIE
Phosphorylation Network Visualize
Domain organization, Expression, Diseases(show / hide)
Localization, Function, Catalytic activity and Sequence(show / hide)
Motif information from Eukaryotic Linear Motif atlas (ELM)(show / hide)
Gene Ontology (P: Process; F: Function and C: Component terms)(show / hide)