Collapse Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
299 KEGG pathways;
876 Reactome pathways;
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023




Gene Name DUSP4 (QuickGO)
Interactive visualization DUSP4 structures
(A quick tutorial to explore the interctive visulaization)

Synonyms DUSP4, MKP2, VH2
Protein Name DUSP4
Alternative Name(s)
Dual specificity protein phosphatase 4;;;Dual specificity protein phosphatase hVH2;Mitogen-activated protein kinase phosphatase 2;MAP kinase phosphatase 2;MKP-2;
EntrezGene ID1846   (Comparitive Toxicogenomics)
UniProt AC (Human) Q13115 (protein sequence)
Enzyme ClassEC (BRENDA )
Molecular Weight42953 Dalton
Protein Length394 amino acids (AA)
Genome Browsers NCBI | ENSG00000120875 (Ensembl) | UCSC
Crosslinking annotations Query our ID-mapping table
Orthologues Quest For Orthologues (QFO) | GeneTree
Classification Superfamily: Class I Cys-based PTPs --> Family: DSP | Historic class: Class I Cys-based PTPs --> VH1-like or DSPs --> MKPs | CATH ID: | SCOP Fold: CC1
Phosphatase activityactive | Catalytic signature motif: HCQAGISR
Domain organization, Expression, Diseases(show / hide)
Localization, Function, Catalytic activity and Sequence(show / hide)
Motif information from Eukaryotic Linear Motif atlas (ELM)(show / hide)
Gene Ontology (P: Process; F: Function and C: Component terms)(show / hide)