Top PTPRJ
Gene Name PTPRJ (QuickGO )Interactive visualization PTPRJ structures tutorial to explore the interctive visulaization)
Synonyms PTPRJ, DEP1
Protein Name PTPRJ
Alternative Name(s) Receptor-type tyrosine-protein phosphatase eta;Protein-tyrosine phosphatase eta;R-PTP-eta;3.1.3.48;Density-enhanced phosphatase 1;DEP-1;HPTP eta;Protein-tyrosine phosphatase receptor type J;R-PTP-J;CD148;
EntrezGene ID 5795 (Comparitive Toxicogenomics)
UniProt AC (Human) Q12913 (protein sequence )
Enzyme Class EC 3.1.3.48 (BRENDA Molecular Weight 145941 Dalton Protein Length 1337 amino acids (AA) Genome Browsers NCBI | ENSG00000149177 (Ensembl) | UCSC Crosslinking annotations Query our ID-mapping tableOrthologues Quest For Orthologues (QFO) | GeneTree Classification Superfamily: Class I Cys-based PTPs --> Family: R-PTP | Historic class: Class I Cys-based PTPs --> Classical PTPs --> Receptor-type PTPs (R-PTPs) | CATH ID: 3.90.190.10 | SCOP Fold: CC1 Phosphatase activity active | Catalytic signature motif: HCSAGVGR Phosphorylation Network Visualize
Localization (UniProt annotation) Cell membrane; Single-pass type I membraneprotein Cell projection, ruffle membrane Celljunction Note=After T-cell stimulation, it is temporarilyexcluded from immunological synapses Function (UniProt annotation) Tyrosine phosphatase which dephosphorylates orcontributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET,RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1,OCLN, PIK3R1 and PIK3R2 Plays a role in cell adhesion, migration,proliferation and differentiation Involved in vasculardevelopment Regulator of macrophage adhesion and spreadingPositively affects cell-matrix adhesion Positive regulator ofplatelet activation and thrombosis Negative regulator of cellproliferation Negative regulator of PDGF-stimulated cellmigration; through dephosphorylation of PDGFR Positive regulatorof endothelial cell survival, as well as of VEGF-induced SRC andAKT activation; through KDR dephosphorylation Negative regulatorof EGFR signaling pathway; through EGFR dephosphorylationEnhances the barrier function of epithelial junctions duringreassembly Negatively regulates T-cell receptor (TCR) signalingUpon T-cell TCR activation, it is up-regulated and excluded fromthe immunological synapses, while upon T-cell-antigen presentingcells (APC) disengagement, it is no longer excluded and candephosphorylate PLCG1 and LAT to down-regulate prolongation ofsignaling Catalytic Activity (UniProt annotation) Protein tyrosine phosphate + H(2)O = proteintyrosine + phosphate Protein Sequence MKPAAREARLPPRSPGLRWALPLLLLLLRLGQILCAGGTPSPIPDPSVATVATGENGITQISSTAESFHKQNGTGTPQVE
TNTSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTGPSPVFDIKAVSISPTNVILTWKSNDTAASEYKYVVKHKMENE
KTITVVHQPWCNITGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVALTGVRKAALSWSNGNGTASCRVLL
ESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSRAGSPTAPVHDESLVGPVDPS
SGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWKVSDNESSSNYTYK
IHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAE
SFQMHITQEGAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDW
KSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTA
ATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTDPA
SMASFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRTEVTYLNFSTSYNISITTVSCGK
MAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAVILTTGEAGHPSADVLKYTYEDFKKGASD
TYVTYLIRTEEKGRSQSLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSRY
SDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKRKDAKNNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCG
FAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTL
KDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHF
TSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPL
MVQTEDQYVFLNQCVLDIVRSQKDSKVDLIYQNTTAMTIYENLAPVTTFGKTNGYIA
ELM Motif Motif Instance Description Motif Regex NA NA NA NA
Download FASTA sequences of PTPRJ-substrates in HumansSubstrate Gene Name Substrate UniProt_AC DephosphoSite and sequence (+/-5) Bioassay Type PubMed ID View in Europe PMC Reliability of the interaction SRC P12931 Tyr-530 _STEPQyQPGEN In vitro and in vivo 15735685 , 20345711 , Europe PMC OCLN Q16625 NA In vitro and in vivo 19332538 , Europe PMC TJP1 Q07157 NA In vitro and in vivo 19332538 , Europe PMC KDR P35968 Tyr-1054_LARDIyKDPDY, Tyr-1059_YKDPDyVRKGD In vitro and in vivo 18936167 , Europe PMC MAPK1 P28482 Tyr-185_GFLTEyVATRW In vitro and in vivo 19494114 , Europe PMC PIK3R1 P27986 NA In vitro and in vivo 18348712 , Europe PMC MAPK3 P27361 Tyr-204_GFLTEyVATRW In vitro and in vivo 19494114 , Europe PMC PDGFRB P09619 Tyr-751_DESVDyVPMLD, Tyr-1021 _EGDNDyIIPLP In vitro and in vivo 12062403 , 10821867 , Europe PMC MET P08581 Tyr-1349_FIGEHyVHVNA, Tyr-1365 _KCVAPyPSLLS In vitro and in vivo 12475979 , Europe PMC RET P07949 Tyr-905_YEEDSyVKRSQ, Tyr-1062_IENKLyGMSDP In vitro and in vivo 16778204 , Europe PMC PLCG1 P19174 NA In vitro 11259588 , Europe PMC CBL P22681 Tyr-731_IDSCTyEAMYN In vivo 19836242 , Europe PMC LYN P07948 Tyr-508 _ATEGQyQQQP- In vitro 20345711 , Europe PMC FYN P06241 Tyr-531 _ATEPQyQPGEN In vitro 20345711 , Europe PMC EGFR P00533 Tyr-1069_SFLQRySSDPT, Tyr-1092_LPVPEyINQSV, Tyr-1197 _AENAEyLRVAP In vivo 19836242 , Europe PMC CTNND1 O60716 NA In vitro 12370829 , Europe PMC LAT O43561 NA In vitro 11259588 , Europe PMC
Pathway ID Pathway Name Pathway Description (KEGG) hsa04520 Adherens junction Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains. Prior to T cell receptor (TCR) stimulation, CD4/CD8 associated Lck remains seperated from the TCR and is maintained in an inactive state by the action of Csk. Csk phosphorylates the negative regulatory tyrosine of Lck and inactivates the Lck kinase domain. Upon TCR stimulation, CD4/CD8 associated Lck co-localizes with the TCR leading to the phosphorylation of the CD3 and TCR subunit. Lck becomes activated by way of CD45-mediated dephosphorylation of negative regulatory tyrosine residues. The presence to PAG-bound Csk is further reduced via the dephosphorylation of PAG (step 1).
Lck is further activated by trans-autophosphorylation on the tyrosine residue on its activation loop (step 2). Active Lck further phosphorylates the tyrosine residues on CD3 chains. The signal-transducing CD3 delta/epsilon/gamma and TCR zeta chains contain a critical signaling motif known as the immunoreceptor tyrosine-based activation motif (ITAM). The two critical tyrosines of each ITAM motif are phosphorylated by Lck (step 3)
R-HSA-6798695 Neutrophil degranulation. Neutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and migrate towards the inflammatory focus. They contain several subsets of granules that are mobilized to fuse with the cell membrane or phagosomal membrane, resulting in the exocytosis or exposure of membrane proteins. Traditionally, neutrophil granule constituents are described as antimicrobial or proteolytic, but granules also introduce membrane proteins to the cell surface, changing how the neutrophil responds to its environment (Borregaard et al. 2007). Primed neutrophils actively secrete cytokines and other inflammatory mediators and can present antigens via MHC II, stimulating T-cells (Wright et al. 2010).Granules form during neutrophil differentiation. Granule subtypes can be distinguished by their content but overlap in structure and composition. The differences are believed to be a consequence of changing protein expression and differential timing of granule formation during the terminal processes of neutrophil differentiation, rather than sorting (Le Cabec et al. 1996). The classical granule subsets are Azurophil or primary granules (AG), secondary granules (SG) and gelatinase granules (GG). Neutrophils also contain exocytosable storage cell organelles, storage vesicles (SV), formed by endocytosis they contain many cell-surface markers and extracellular, plasma proteins (Borregaard et al. 1992). Ficolin-1-rich granules (FG) are like GGs highly exocytosable but gelatinase-poor (Rorvig et al. 2009) R-HSA-6807004 Negative regulation of MET activity. Signaling by MET receptor is negatively regulated mainly by MET receptor dephosphorylation or MET receptor degradation. Protein tyrosine phosphatase PTPRJ dephosphorylates MET tyrosine residue Y1349, thus removing the docking site for the GAB1 adapter (Palka et al. 2003). Protein tyrosine phosphatases PTPN1 and PTPN2 dephosphorylate MET tyrosines Y1234 and Y1235 in the kinase activation loop, thus attenuating catalytic activity of MET (Sangwan et al. 2008). The E3 ubiquitin ligase CBL promotes ubiquitination of the activated MET receptor and subsequent MET degradation. CBL contains a RING finger domain that engages E2 protein ubiquitin ligases to mediate ubiquitination of MET, which may occur at the cell membrane or in the early endocytic compartment. Ubiquitinated MET is degraded in a late endosomal or lysosomal compartment in a proteasome-dependent manner. The involvement of proteasome in MET degradation seems to be indirect, through an effect on MET endocytic trafficking (Jeffers et al. 1997, Peschard et al. 2001, Hammond et al. 2001, Petrelli et al. 2002). LRIG1 promotes lysosome-dependent degradation of MET in the absence of HGF-mediated activation (Lee et al. 2014, Oh et al. 2014).MET-mediated activation of RAS signaling is inhibited by MET receptor binding to MUC20 (Higuchi et al. 2004) or RANBP10 (Wang et al. 2004)
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source C19orf25 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID C1orf226 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID CASC3 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT CDH1 Proximity Label-MS physical 25468996 , (Europe PMC )NA BioGRID CTNNB1 Affinity Capture-Western, phosphatase assay, pull down dephosphorylation reaction, physical, physical association 12370829 , 19167335 , (Europe PMC )0.61 BioGRID, IntAct, MINT CTNND1 Affinity Capture-Western, Biochemical Activity, biochemical, coimmunoprecipitation, fluorescence technology, pull down colocalization, dephosphorylation reaction, physical, physical association 12370829 , 12475979 , (Europe PMC )0.72 BioGRID, IntAct, MINT CYP17A1 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT EGFR Affinity Capture-Western, FRET, phosphatase assay dephosphorylation reaction, physical 19167335 , 19836242 , (Europe PMC )0.44 BioGRID, IntAct EPSTI1 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT FBXO6 Affinity Capture-MS physical 22268729 , (Europe PMC )NA BioGRID GRB2 Affinity Capture-MS physical 21706016 , (Europe PMC )NA BioGRID HNRNPL Affinity Capture-RNA physical 28611215 , (Europe PMC )NA BioGRID HOXC6 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT KLK7 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT KLK9 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT LAT Biochemical Activity, biochemical dephosphorylation reaction, physical 11259588 , (Europe PMC )0.44 BioGRID, IntAct, MINT LGALS3 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID LGALS8 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID LGALS9 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID LYPD3 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT NOS1AP Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PLCG1 Biochemical Activity physical 11259588 , (Europe PMC )NA BioGRID PRDM14 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT PTPRJ Co-crystal Structure, biochemical, comigration in sds page, tox-r dimerization assay association, dephosphorylation reaction, direct interaction, physical 11526512 , 15978577 , 19167335 , (Europe PMC )0.66 BioGRID, IntAct, MINT RAB11FIP1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID RINT1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID SDCBP Two-hybrid physical 12403354 , (Europe PMC )NA BioGRID TRIM25 Affinity Capture-RNA, Two-hybrid, two hybrid array physical, physical association 25640309 , 29117863 , (Europe PMC )0.37 BioGRID, IntAct, MINT
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ANP32B two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT BAAT two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT BAP1 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT CASC3 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT CBL phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct CDH2 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct CSK phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct CTNNB1 Affinity Capture-Western, phosphatase assay, pull down dephosphorylation reaction, physical, physical association 12370829 , 19167335 , (Europe PMC )0.61 BioGRID, IntAct, MINT CTNND1 Affinity Capture-Western, Biochemical Activity, biochemical, coimmunoprecipitation, fluorescence technology, pull down colocalization, dephosphorylation reaction, physical, physical association 12370829 , 12475979 , (Europe PMC )0.72 BioGRID, IntAct, MINT CYP17A1 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT EGFR Affinity Capture-Western, FRET, phosphatase assay dephosphorylation reaction, physical 19167335 , 19836242 , (Europe PMC )0.44 BioGRID, IntAct EPOR phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct EPSTI1 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT ERBB2 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct FANCC two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT FBP1 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT FLT1 biochemical dephosphorylation reaction 12771128 , 16893970 , (Europe PMC )0.62 IntAct, MINT FLT3 proximity ligation assay physical association 23650535 , (Europe PMC )0.40 IntAct GAB1 phosphatase assay, pull down dephosphorylation reaction, physical association 12475979 , 19167335 , (Europe PMC )0.61 IntAct, MINT GHR phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct GRIN2B phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct HEMGN two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT HOXC6 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT HRAS two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT INSR phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct JAK2 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct JUP pull down physical association 12370829 , (Europe PMC )0.40 IntAct, MINT KDR biochemical, coimmunoprecipitation, phosphatase assay, pull down dephosphorylation reaction, physical association 18936167 , (Europe PMC )0.65 IntAct, MINT KIT phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct KLK7 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT KLK9 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT LAT Biochemical Activity, biochemical dephosphorylation reaction, physical 11259588 , (Europe PMC )0.44 BioGRID, IntAct, MINT LCK phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct LEPR phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct LYPD3 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT MAP2K1 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT MAPK1 anti tag coimmunoprecipitation, peptide array, phosphatase assay, pull down association 19494114 , (Europe PMC )0.58 IntAct, MINT MAPK3 anti tag coimmunoprecipitation, peptide array, phosphatase assay, pull down association, dephosphorylation reaction, direct interaction 19167335 , 19494114 , (Europe PMC )0.70 IntAct, MINT MET affinity chromatography technology, biochemical, coimmunoprecipitation, phosphatase assay, pull down dephosphorylation reaction, physical association 12475979 , 19167335 , (Europe PMC )0.73 IntAct, MINT NANS two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT NSF phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct NTRK1 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct PDGFRB biochemical, coimmunoprecipitation, phosphatase assay dephosphorylation reaction, physical association 10821867 , 19167335 , (Europe PMC )0.72 IntAct, MINT PDPK1 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct PKP4 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct PPP1R12A phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct PPP2CB two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT PPP3R2 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT PRDM14 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT PTPRJ Co-crystal Structure, biochemical, comigration in sds page, tox-r dimerization assay association, dephosphorylation reaction, direct interaction, physical 11526512 , 15978577 , 19167335 , (Europe PMC )0.66 BioGRID, IntAct, MINT PXN phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct RASA1 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT SFRP4 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT TEC phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct TEK phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct TIE1 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct TMEFF1 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT TNK2 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct TRIM25 Affinity Capture-RNA, Two-hybrid, two hybrid array physical, physical association 25640309 , 29117863 , (Europe PMC )0.37 BioGRID, IntAct, MINT TRMO two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT TSTD2 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT WAS phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct ZNF510 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source BAAT two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT BAP1 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT CASC3 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT CTNNB1 Affinity Capture-Western, phosphatase assay, pull down dephosphorylation reaction, physical, physical association 12370829 , 19167335 , (Europe PMC )0.61 BioGRID, IntAct, MINT CTNND1 Affinity Capture-Western, Biochemical Activity, biochemical, coimmunoprecipitation, fluorescence technology, pull down colocalization, dephosphorylation reaction, physical, physical association 12370829 , 12475979 , (Europe PMC )0.72 BioGRID, IntAct, MINT CYP17A1 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT EPSTI1 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT FANCC two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT FBP1 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT FLT1 biochemical dephosphorylation reaction 12771128 , 16893970 , (Europe PMC )0.62 IntAct, MINT GAB1 phosphatase assay, pull down dephosphorylation reaction, physical association 12475979 , 19167335 , (Europe PMC )0.61 IntAct, MINT HEMGN two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT HOXC6 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT HRAS two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT JUP pull down physical association 12370829 , (Europe PMC )0.40 IntAct, MINT KDR biochemical, coimmunoprecipitation, phosphatase assay, pull down dephosphorylation reaction, physical association 18936167 , (Europe PMC )0.65 IntAct, MINT KLK7 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT KLK9 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT LAT Biochemical Activity, biochemical dephosphorylation reaction, physical 11259588 , (Europe PMC )0.44 BioGRID, IntAct, MINT LYPD3 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT MAP2K1 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT MAPK1 anti tag coimmunoprecipitation, peptide array, phosphatase assay, pull down association 19494114 , (Europe PMC )0.58 IntAct, MINT MAPK3 anti tag coimmunoprecipitation, peptide array, phosphatase assay, pull down association, dephosphorylation reaction, direct interaction 19167335 , 19494114 , (Europe PMC )0.70 IntAct, MINT MET affinity chromatography technology, biochemical, coimmunoprecipitation, phosphatase assay, pull down dephosphorylation reaction, physical association 12475979 , 19167335 , (Europe PMC )0.73 IntAct, MINT NANS two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT PDGFRB biochemical, coimmunoprecipitation, phosphatase assay dephosphorylation reaction, physical association 10821867 , 19167335 , (Europe PMC )0.72 IntAct, MINT PPP2CB two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT PPP3R2 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT PRDM14 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT PTPRJ Co-crystal Structure, biochemical, comigration in sds page, tox-r dimerization assay association, dephosphorylation reaction, direct interaction, physical 11526512 , 15978577 , 19167335 , (Europe PMC )0.66 BioGRID, IntAct, MINT RASA1 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT SFRP4 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT TMEFF1 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT TRIM25 Affinity Capture-RNA, Two-hybrid, two hybrid array physical, physical association 25640309 , 29117863 , (Europe PMC )0.37 BioGRID, IntAct, MINT TRMO two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT TSTD2 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT ZNF510 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ANP32B two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT BAAT two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT BAP1 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT C19orf25 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID C1orf226 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID CASC3 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT CBL phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct CDH1 Proximity Label-MS physical 25468996 , (Europe PMC )NA BioGRID CDH2 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct CSK phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct CTNNB1 Affinity Capture-Western, phosphatase assay, pull down dephosphorylation reaction, physical, physical association 12370829 , 19167335 , (Europe PMC )0.61 BioGRID, IntAct, MINT CTNND1 Affinity Capture-Western, Biochemical Activity, biochemical, coimmunoprecipitation, fluorescence technology, pull down colocalization, dephosphorylation reaction, physical, physical association 12370829 , 12475979 , (Europe PMC )0.72 BioGRID, IntAct, MINT CYP17A1 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT EGFR Affinity Capture-Western, FRET, phosphatase assay dephosphorylation reaction, physical 19167335 , 19836242 , (Europe PMC )0.44 BioGRID, IntAct EPOR phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct EPSTI1 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT ERBB2 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct FANCC two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT FBP1 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT FBXO6 Affinity Capture-MS physical 22268729 , (Europe PMC )NA BioGRID FLT1 biochemical dephosphorylation reaction 12771128 , 16893970 , (Europe PMC )0.62 IntAct, MINT FLT3 proximity ligation assay physical association 23650535 , (Europe PMC )0.40 IntAct GAB1 phosphatase assay, pull down dephosphorylation reaction, physical association 12475979 , 19167335 , (Europe PMC )0.61 IntAct, MINT GHR phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct GRB2 Affinity Capture-MS physical 21706016 , (Europe PMC )NA BioGRID GRIN2B phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct HEMGN two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT HNRNPL Affinity Capture-RNA physical 28611215 , (Europe PMC )NA BioGRID HOXC6 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT HRAS two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT INSR phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct JAK2 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct JUP pull down physical association 12370829 , (Europe PMC )0.40 IntAct, MINT KDR biochemical, coimmunoprecipitation, phosphatase assay, pull down dephosphorylation reaction, physical association 18936167 , (Europe PMC )0.65 IntAct, MINT KIT phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct KLK7 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT KLK9 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT LAT Biochemical Activity, biochemical dephosphorylation reaction, physical 11259588 , (Europe PMC )0.44 BioGRID, IntAct, MINT LCK phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct LEPR phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct LGALS3 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID LGALS8 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID LGALS9 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID LYPD3 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT MAP2K1 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT MAPK1 anti tag coimmunoprecipitation, peptide array, phosphatase assay, pull down association 19494114 , (Europe PMC )0.58 IntAct, MINT MAPK3 anti tag coimmunoprecipitation, peptide array, phosphatase assay, pull down association, dephosphorylation reaction, direct interaction 19167335 , 19494114 , (Europe PMC )0.70 IntAct, MINT MET affinity chromatography technology, biochemical, coimmunoprecipitation, phosphatase assay, pull down dephosphorylation reaction, physical association 12475979 , 19167335 , (Europe PMC )0.73 IntAct, MINT NANS two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT NOS1AP Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID NSF phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct NTRK1 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct PDGFRB biochemical, coimmunoprecipitation, phosphatase assay dephosphorylation reaction, physical association 10821867 , 19167335 , (Europe PMC )0.72 IntAct, MINT PDPK1 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct PKP4 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct PLCG1 Biochemical Activity physical 11259588 , (Europe PMC )NA BioGRID PPP1R12A phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct PPP2CB two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT PPP3R2 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT PRDM14 Two-hybrid, two hybrid array physical, physical association 25640309 , (Europe PMC )0.37 BioGRID, IntAct, MINT PTPRJ Co-crystal Structure, biochemical, comigration in sds page, tox-r dimerization assay association, dephosphorylation reaction, direct interaction, physical 11526512 , 15978577 , 19167335 , (Europe PMC )0.66 BioGRID, IntAct, MINT PXN phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct RAB11FIP1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID RASA1 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT RINT1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID SDCBP Two-hybrid physical 12403354 , (Europe PMC )NA BioGRID SFRP4 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT TEC phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct TEK phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct TIE1 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct TMEFF1 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT TNK2 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct TRIM25 Affinity Capture-RNA, Two-hybrid, two hybrid array physical, physical association 25640309 , 29117863 , (Europe PMC )0.37 BioGRID, IntAct, MINT TRMO two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT TSTD2 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT WAS phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct ZNF510 two hybrid array physical association 24412244 , (Europe PMC )0.37 IntAct, MINT
Phosphorylating Kinases Phosphoresidues Detection Method PubMed IDs Source
Visualize a network of protein kinases and phosphatases phosphorylating and dephosphorylating this protein respectively
FYN Y1311_DSKVDLIyQNTTAMT , Y1320_NTTAMTIyENLAPVT , NA NA PhosphoSitePlus , SRC Y1311_DSKVDLIyQNTTAMT , Y1320_NTTAMTIyENLAPVT , NA NA PhosphoSitePlus , Unknown S1009_DAKNNEVsFSQIKPK , S1011_KNNEVSFsQIKPKKS , T1201_PLRQFHFtSWPDHGV , in vivo 19651622 , 20068231 ,(Europe PMC )HPRD,
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