Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
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INPP5F
Gene Name  | INPP5F (QuickGO) | (A quick tutorial to explore the interctive visulaization) |
| Synonyms | INPP5F , KIAA0966, SAC2 | |
| Protein Name | INPP5F |
|
| Alternative Name(s) |
Phosphatidylinositide phosphatase SAC2;3.1.3.25;Inositol polyphosphate 5-phosphatase F;Sac domain-containing inositol phosphatase 2;Sac domain-containing phosphoinositide 4-phosphatase 2;hSAC2; | |
| EntrezGene ID | 22876 (Comparitive Toxicogenomics) | |
| UniProt AC (Human) | Q9Y2H2 (protein sequence) | |
| Enzyme Class | EC 3.1.3.25 (BRENDA ) | |
| Molecular Weight | 128407 Dalton | |
| Protein Length | 1132 amino acids (AA) | |
| Genome Browsers | NCBI | ENSG00000198825 (Ensembl) | UCSC | |
| Crosslinking annotations | Query our ID-mapping table | |
| Orthologues | Quest For Orthologues (QFO) | GeneTree | |
| Classification | Superfamily: SAC domain phosphatases | Historic class: SAC domain family | CATH ID: NA | SCOP Fold: CC1 | |
| Phosphatase activity | active | Catalytic signature motif: NCMDCLDR | |
| Phosphorylation Network | Visualize | |
| Domain organization, Expression, Diseases | (show / hide) |
| Protein Domain | InterPro | Pfam | SMART | 3D Structure | PDB | DrugPort | ModBase | SwissModel |
| Polypeptide organization (Pfam) | No Pfam domain found | ||
| Catalytic Site | Mechanism and Catalytic Site Atlas | ||
| Gene Expression | Gene Expression Atlas | Diseases | OMIM | DisGeNet | ClinVar |
| Protein-protein interactions | STRING | IntAct | MINT | BioGRID | ||
| Phosphosites | Phospho.ELM | PhosphoSitePlus | ||
| Localization, Function, Catalytic activity and Sequence | (show / hide) |
| Localization (UniProt annotation) | |||
| Membrane, clathrin-coated pit Early endosome Recycling endosome Note=Also found on macropinosomes | |||
| Function (UniProt annotation) | |||
| Inositol 4-phosphatase which mainly acts onphosphatidylinositol 4-phosphate May be functionally linked toOCRL, which converts phosphatidylinositol 4,5-bisphosphate tophosphatidylinositol, for a sequential dephosphorylation ofphosphatidylinositol 4,5-bisphosphate at the 5 and 4 position ofinositol, thus playing an important role in the endocyticrecycling (PubMed:25869669) Regulator of TF:TFRC and integrinsrecycling pathway, is also involved in cell migration mechanisms(PubMed:25869669) Modulates AKT/GSK3B pathway by decreasing AKTand GSK3B phosphorylation (PubMed:17322895) Negatively regulatesSTAT3 signaling pathway through inhibition of STAT3phosphorylation and translocation to the nucleus(PubMed:25476455) Functionally important modulator of cardiacmyocyte size and of the cardiac response to stress (Bysimilarity) May play a role as negative regulator of axonregeneration after central nervous system injuries (Bysimilarity) | |||
| Catalytic Activity (UniProt annotation) | |||
| Myo-inositol phosphate + H(2)O = myo-inositol+ phosphate | |||
| Protein Sequence | |||
| MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPICLGLVEGVIGKIQLHSDLPWWLILIRQKALVGKLPGD HEVCKVTKIAVLSLSEMEPQDLELELCKKHHFGINKPEKIIPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESKEKEKLER RLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQDLTEIGTPDVDFWIIPMIQGFVQ IEELVVNYTESSDDEKSSPETPPQESTCVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHT LSFVQTRGSVPVFWSQVGYRYNPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKIIGDAYLKQVLLFNN SHLTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWCWVDEAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQ LKKLGVMPPEQPLPVKCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQA VIDLMQGIPVTEDLYSIFTKEKEHEALHKENQRSHQELISQLLQSYMKLLLPDDEKFHGGWALIDCDPSLIDATHRDVDV LLLLSNSAYYVAYYDDEVDKVNQYQRLSLENLEKIEIGPEPTLFGKPKFSCMRLHYRYKEASGYFHTLRAVMRNPEEDGK DTLQCIAEMLQITKQAMGSDLPIIEKKLERKSSKPHEDIIGIRSQNQGSLAQGKNFLMSKFSSLNQKVKQTKSNVNIGNL RKLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETMENTGVMDKVQAESDGDMSSDNDSYHSDEFLTNSKSDEDRQLANSLE SVGPIDYVLPSCGIIASAPRLGSRSQSLSSTDSSVHAPSEITVAHGSGLGKGQESPLKKSPSAGDVHILTGFAKPMDIYC HRFVQDAQNKVTHLSETRSVSQQASQERNQMTNQVSNETQSESTEQTPSRPSQLDVSLSATGPQFLSVEPAHSVASQKTP TSASSMLELETGLHVTPSPSESSSSRAVSPFAKIRSSMVQVASITQAGLTHGINFAVSKVQKSPPEPEIINQVQQNELKK MFIQCQTRIIQI |
| Motif information from Eukaryotic Linear Motif atlas (ELM) | (show / hide) |
ELM Motif | Motif Instance | Description | Motif Regex |
| DOC_MAPK_JIP1_4 | 1010-RPSQLDV-1016 | MAPK docking motifs | [RK]P[^P][^P]L.[LIVMF] |
| Gene Ontology (P: Process; F: Function and C: Component terms) | (show / hide) | |
| GO:0001921 | P:positive regulation of receptor recycling |
| GO:0005769 | C:early endosome |
| GO:0005905 | C:clathrin-coated pit |
| GO:0006661 | P:phosphatidylinositol biosynthetic process |
| GO:0008344 | P:adult locomotory behavior |
| GO:0008934 | F:inositol monophosphate 1-phosphatase activity |
| GO:0014898 | P:cardiac muscle hypertrophy in response to stress |
| GO:0030424 | C:axon |
| GO:0030425 | C:dendrite |
| GO:0031161 | P:phosphatidylinositol catabolic process |
| GO:0031901 | C:early endosome membrane |
| GO:0033137 | P:negative regulation of peptidyl-serine phosphorylation |
| GO:0034595 | F:phosphatidylinositol phosphate 5-phosphatase activity |
| GO:0034596 | F:phosphatidylinositol phosphate 4-phosphatase activity |
| GO:0042532 | P:negative regulation of tyrosine phosphorylation of STAT protein |
| GO:0042803 | F:protein homodimerization activity |
| GO:0043025 | C:neuronal cell body |
| GO:0045334 | C:clathrin-coated endocytic vesicle |
| GO:0046856 | P:phosphatidylinositol dephosphorylation |
| GO:0048015 | P:phosphatidylinositol-mediated signaling |
| GO:0048681 | P:negative regulation of axon regeneration |
| GO:0051896 | P:regulation of protein kinase B signaling |
| GO:0052832 | F:inositol monophosphate 3-phosphatase activity |
| GO:0052833 | F:inositol monophosphate 4-phosphatase activity |
| GO:0055037 | C:recycling endosome |
| GO:0072583 | P:clathrin-dependent endocytosis |
| GO:2000145 | P:regulation of cell motility |
| GO:2001135 | P:regulation of endocytic recycling |
