Top PTPN9
Download FASTA sequences of PTPN9-substrates in Humans
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-9008059 Interleukin-37 signaling. Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL37), also known as IL 1F7, is a member of the IL 1 family (Sharma et al. 2008). Isoform b of IL37 (referred just as IL37) is synthesized as a precursor that requires processing (primarily by caspase 1) to attain full receptor agonist or antagonist function (Kumar et al. 2002). Both full length and processed IL37 can bind to the IL 18 binding protein (IL 18BP) and the Interleukin 18 receptor 1 (IL 18R1) (Shi et al. 2003). Upon binding to the IL18R1, IL37 recruits Single Ig IL 1 related receptor (SIGIRR) (Nold-Petry et al. 2015). The IL37:IL18R1 complex can activate phosphorylation of Signal transducer and activator of transcription 3 (STAT3), Tyrosine protein kinase Mer and Phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN and can also inhibit Nuclear factor NF kappa B p105 subunit (NFKB) (Nold-Petry et al. 2015). Processed IL37 can be secreted from the cytosol to the extracellular space or translocated into the nucleus (Bulau et al. 2014). Full length IL37 can also be secreted from the cytosol to the extracellular space (Bulau et al. 2014). Processed IL37 can bind with Mothers against decapentaplegic homolog 3 (SMAD3) in the cytosol and then translocate to the nucleus, where it facilitates transcription of Tyrosine protein phosphatase non receptors (PTPNs) (Nold et al. 2010, Luo et al. 2017). These events ultimately lead to suppression of cytokine production in several types of immune cells resulting in reduced inflammation
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source AGTRAP Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 21516116 , 25416956 , Europe PMC )0.49, 0.67 BioGRID, IntAct, MINT C5AR2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CALHM4 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CMTM5 Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 21516116 , 25416956 , Europe PMC )0.49, 0.67 BioGRID, IntAct, MINT CREB3 Two-hybrid, two hybrid physical, physical association 21516116 , (Europe PMC )0.37 BioGRID, IntAct, MINT DDX20 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID ENO1 Affinity Capture-RNA physical 22658674 , (Europe PMC )NA BioGRID EYA1 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID FSIP1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID GEMIN4 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID GEMIN8 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID GHR Far Western, Reconstituted Complex, array technology, phosphatase assay dephosphorylation reaction, direct interaction, physical 12907755 , (Europe PMC )0.56 BioGRID, IntAct LMNA Two-hybrid physical 24623722 , (Europe PMC )NA BioGRID LZTR1 Affinity Capture-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID MAL2 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct MDK Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MOV10 Affinity Capture-RNA physical 22658674 , (Europe PMC )NA BioGRID MYC Dosage Lethality genetic 22623531 , (Europe PMC )NA BioGRID NTRK1 Affinity Capture-MS physical 25921289 , (Europe PMC )NA BioGRID NXF1 Affinity Capture-RNA physical 22658674 , (Europe PMC )NA BioGRID PC Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID PDCD1 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PMPCA Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID PTPN9 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID RAD51C Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID REEP6 Two-hybrid, two hybrid array, two hybrid prey pooling approach physical, physical association 25416956 , Europe PMC )0.49 BioGRID, IntAct RTN3 Two-hybrid, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach, validated two hybrid physical, physical association 16189514 , 25416956 , Europe PMC )0.49, 0.67 BioGRID, IntAct SLC39A7 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SMN1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SMN2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID STRAP Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TP53BP1 Affinity Capture-MS physical 22990118 , (Europe PMC )NA BioGRID TUBA3C Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TUBA3D Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID VCP Affinity Capture-MS physical 23383273 , (Europe PMC )NA BioGRID VSIG8 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source CMTM5 Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 21516116 , 25416956 , Europe PMC )0.49, 0.67 BioGRID, IntAct, MINT CREB3 Two-hybrid, two hybrid physical, physical association 21516116 , (Europe PMC )0.37 BioGRID, IntAct, MINT GAB1 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct GHR Far Western, Reconstituted Complex, array technology, phosphatase assay dephosphorylation reaction, direct interaction, physical 12907755 , (Europe PMC )0.56 BioGRID, IntAct MAL2 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct NSF phosphatase assay, pull down dephosphorylation reaction, physical association 15322554 , (Europe PMC )0.54 IntAct, MINT REEP6 Two-hybrid, two hybrid array, two hybrid prey pooling approach physical, physical association 25416956 , Europe PMC )0.49 BioGRID, IntAct RTN3 Two-hybrid, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach, validated two hybrid physical, physical association 16189514 , 25416956 , Europe PMC )0.49, 0.67 BioGRID, IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source CMTM5 Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 21516116 , 25416956 , Europe PMC )0.49, 0.67 BioGRID, IntAct, MINT CREB3 Two-hybrid, two hybrid physical, physical association 21516116 , (Europe PMC )0.37 BioGRID, IntAct, MINT NSF phosphatase assay, pull down dephosphorylation reaction, physical association 15322554 , (Europe PMC )0.54 IntAct, MINT
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source AGTRAP Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 21516116 , 25416956 , Europe PMC )0.49, 0.67 BioGRID, IntAct, MINT C5AR2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CALHM4 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CMTM5 Two-hybrid, two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 21516116 , 25416956 , Europe PMC )0.49, 0.67 BioGRID, IntAct, MINT CREB3 Two-hybrid, two hybrid physical, physical association 21516116 , (Europe PMC )0.37 BioGRID, IntAct, MINT DDX20 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID ENO1 Affinity Capture-RNA physical 22658674 , (Europe PMC )NA BioGRID EYA1 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID FSIP1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID GAB1 phosphatase assay dephosphorylation reaction 19167335 , (Europe PMC )0.44 IntAct GEMIN4 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID GEMIN8 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID GHR Far Western, Reconstituted Complex, array technology, phosphatase assay dephosphorylation reaction, direct interaction, physical 12907755 , (Europe PMC )0.56 BioGRID, IntAct LMNA Two-hybrid physical 24623722 , (Europe PMC )NA BioGRID LZTR1 Affinity Capture-MS physical 27432908 , 27880917 , (Europe PMC )NA BioGRID MAL2 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct MDK Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MOV10 Affinity Capture-RNA physical 22658674 , (Europe PMC )NA BioGRID MYC Dosage Lethality genetic 22623531 , (Europe PMC )NA BioGRID NSF phosphatase assay, pull down dephosphorylation reaction, physical association 15322554 , (Europe PMC )0.54 IntAct, MINT NTRK1 Affinity Capture-MS physical 25921289 , (Europe PMC )NA BioGRID NXF1 Affinity Capture-RNA physical 22658674 , (Europe PMC )NA BioGRID PC Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID PDCD1 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PMPCA Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID PTPN9 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID RAD51C Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID REEP6 Two-hybrid, two hybrid array, two hybrid prey pooling approach physical, physical association 25416956 , Europe PMC )0.49 BioGRID, IntAct RTN3 Two-hybrid, two hybrid array, two hybrid pooling approach, two hybrid prey pooling approach, validated two hybrid physical, physical association 16189514 , 25416956 , Europe PMC )0.49, 0.67 BioGRID, IntAct SLC39A7 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SMN1 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID SMN2 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID STRAP Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TP53BP1 Affinity Capture-MS physical 22990118 , (Europe PMC )NA BioGRID TUBA3C Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID TUBA3D Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID VCP Affinity Capture-MS physical 23383273 , (Europe PMC )NA BioGRID VSIG8 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID
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