Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - Small cell lung cancer - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| PTEN | P60484 | PDGFRB, CREB1, SHC1, PTEN, PTK2, PTK6, | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate, 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate, 1D-myo-inositol 1,3,4,5-tetrakisphosphate, 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate, 1-phosphatidyl-1D-myo-inositol 3-phosphate, |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| IKBKB | O14920 | PPP2CA, PPP2CB, PPM1A, PPM1B, PPM1M, |
| CHUK | O15111 | PPP2CA, PPP2CB, |
| MYC | P01106 | PPP2CA, PPP2CB, CTDSP1, |
| TP53 | P04637 | CDC14A, CDC14B, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, PPM1D, DUSP26, |
| ITGB1 | P05556 | PPP2CA, PPP2CB, PTP4A3, |
| RB1 | P06400 | PPP1CA, PPP1CB, PPP1CC, CTDSPL, PPP2CA, PPP2CB, |
| BCL2 | P10415 | PPP2CA, PPP2CB, |
| CDK4 | P11802 | CDC25A, |
| CDK2 | P24941 | CDC25A, CDKN3, PPP2CA, PPP2CB, PPM1A, PPM1B, |
| NFKBIA | P25963 | PTPN1, PTPN13, PPP3CB, PPP3CC, PPP2CB, PPP2CA, PPP3CA, |
| PIK3R1 | P27986 | PPM1A, PTPRJ, |
| AKT1 | P31749 | ACP1, PHLPP1, PHLPP2, PPP2CA, PPP2CB, PPP1CA, PPP1CB, PPP1CC, CTDSP1, |
| AKT2 | P31751 | PHLPP1, PHLPP2, |
| CASP3 | P42574 | PPP2CA, PPP2CB, |
| CDKN1B | P46527 | CDC14A, PPM1H, PPP2CB, PPP2CA, |
| CASP9 | P55211 | PPP1CA, |
| PTEN | P60484 | PTEN, PPP2CA, |
| CDK6 | Q00534 | PPM1A, PPM1B, |
| RELA | Q04206 | PPP2CA, PPP4C, PPP2CB, |
| PTK2 | Q05397 | PTPN23, ACP1, PPP1CA, PPP1CB, PPP1CC, PTEN, PTPN1, PTPN12, UBASH3B, |
| BAX | Q07812 | PPP2CA, PPP2CB, |
| TRAF2 | Q12933 | PPP2CA, PPP2CB, |
| SKP2 | Q13309 | CDC14B, |
| BAK1 | Q16611 | PTPN5, |
| AKT3 | Q9Y243 | PHLPP1, PHLPP2, PPP2CA, PPP2CB, |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:16618 | C05981 | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate |  | TNS2, FIG4, INPP5B, INPP5E, INPP5K, OCRL, PTEN, PTPRQ, INPP5F, INPP5D, INPPL1, SYNJ1, SYNJ2, TPTE2, |