Top PTPN23
Download FASTA sequences of PTPN23-substrates in Humans
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-9008059 Interleukin-37 signaling. Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL37), also known as IL 1F7, is a member of the IL 1 family (Sharma et al. 2008). Isoform b of IL37 (referred just as IL37) is synthesized as a precursor that requires processing (primarily by caspase 1) to attain full receptor agonist or antagonist function (Kumar et al. 2002). Both full length and processed IL37 can bind to the IL 18 binding protein (IL 18BP) and the Interleukin 18 receptor 1 (IL 18R1) (Shi et al. 2003). Upon binding to the IL18R1, IL37 recruits Single Ig IL 1 related receptor (SIGIRR) (Nold-Petry et al. 2015). The IL37:IL18R1 complex can activate phosphorylation of Signal transducer and activator of transcription 3 (STAT3), Tyrosine protein kinase Mer and Phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN and can also inhibit Nuclear factor NF kappa B p105 subunit (NFKB) (Nold-Petry et al. 2015). Processed IL37 can be secreted from the cytosol to the extracellular space or translocated into the nucleus (Bulau et al. 2014). Full length IL37 can also be secreted from the cytosol to the extracellular space (Bulau et al. 2014). Processed IL37 can bind with Mothers against decapentaplegic homolog 3 (SMAD3) in the cytosol and then translocate to the nucleus, where it facilitates transcription of Tyrosine protein phosphatase non receptors (PTPNs) (Nold et al. 2010, Luo et al. 2017). These events ultimately lead to suppression of cytokine production in several types of immune cells resulting in reduced inflammation
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ARMH3 Synthetic Lethality genetic 26472760 , (Europe PMC )NA BioGRID AURKA Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID CEP55 Two-hybrid physical 25416956 , (Europe PMC )NA BioGRID CHMP4B Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, pull down, two hybrid direct interaction, physical, physical association 17174262 , 18434552 , (Europe PMC )0.66 BioGRID, IntAct, MINT CLINT1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID CLTA Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID CLTB Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID CLTC Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , 27880917 , (Europe PMC )0.35 BioGRID, IntAct DIAPH1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID EGFR Affinity Capture-Western physical 23477725 , (Europe PMC )NA BioGRID FGL1 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID GRAP2 Affinity Capture-MS, anti bait coimmunoprecipitation, far western blotting, fluorescence microscopy, pull down, two hybrid colocalization, physical, physical association 21179510 , 26186194 , 28514442 , (Europe PMC )0.64 BioGRID, IntAct GRB2 Affinity Capture-MS, Co-fractionation, Two-hybrid, anti bait coimmunoprecipitation, far western blotting, fluorescence microscopy, pull down, two hybrid, two hybrid pooling approach colocalization, physical, physical association 20936779 , 21179510 , 26344197 , 28514442 , (Europe PMC )0.72 BioGRID, IntAct HGS Affinity Capture-Western physical 23477725 , 26456826 , (Europe PMC )NA BioGRID ITGA4 Affinity Capture-MS physical 22623428 , (Europe PMC )NA BioGRID KIF20A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct KIF5B Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID KLC1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID KLC2 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID LAGE3 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID LGR4 Affinity Capture-MS physical 24639526 , (Europe PMC )NA BioGRID LRRK2 Two-hybrid physical 19001729 , (Europe PMC )NA BioGRID NOTCH2NLA Two-hybrid physical 25416956 , (Europe PMC )NA BioGRID NTRK1 Affinity Capture-MS physical 25921289 , (Europe PMC )NA BioGRID P3H1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID PDCD6IP Affinity Capture-Western physical 17174262 , (Europe PMC )NA BioGRID PPP4R3B Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PRDX5 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PSMA3 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct SH3GL2 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, two hybrid physical, physical association 17174262 , (Europe PMC )0.51 BioGRID, IntAct, MINT STAM Affinity Capture-Western physical 26456826 , (Europe PMC )NA BioGRID STAM2 Affinity Capture-Western physical 23477725 , (Europe PMC )NA BioGRID TRIM27 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct TSG101 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, two hybrid physical, physical association 17174262 , 26456826 , (Europe PMC )0.51 BioGRID, IntAct, MINT TUBG1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID UBAP1 Affinity Capture-Western, Co-crystal Structure, Protein-peptide, Reconstituted Complex, Two-hybrid physical 21757351 , 26456826 , 27839950 , (Europe PMC )NA BioGRID UBC Reconstituted Complex physical 26456826 , (Europe PMC )NA BioGRID USP8 Affinity Capture-Western physical 23477725 , (Europe PMC )NA BioGRID VCP Affinity Capture-MS physical 23383273 , (Europe PMC )NA BioGRID VPS26A Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID VWA5A Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ZFYVE16 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source CAD pull down association 28330616 , (Europe PMC )0.35 IntAct CALR pull down association 28330616 , (Europe PMC )0.35 IntAct CEP55 two hybrid array, two hybrid prey pooling approach, validated two hybrid physical association 25416956 , (Europe PMC )0.56 IntAct CHMP4B Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, pull down, two hybrid direct interaction, physical, physical association 17174262 , 18434552 , (Europe PMC )0.66 BioGRID, IntAct, MINT CLTC Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , 27880917 , (Europe PMC )0.35 BioGRID, IntAct DDX24 two hybrid pooling approach physical association 16169070 , (Europe PMC )0.37 IntAct EEA1 proximity-dependent biotin identification association 29568061 , (Europe PMC )0.35 IntAct ESR2 cosedimentation through density gradient association 21182203 , (Europe PMC )0.35 IntAct GLUD1 pull down association 28330616 , (Europe PMC )0.35 IntAct GRAP2 Affinity Capture-MS, anti bait coimmunoprecipitation, far western blotting, fluorescence microscopy, pull down, two hybrid colocalization, physical, physical association 21179510 , 26186194 , 28514442 , (Europe PMC )0.64 BioGRID, IntAct GRB2 Affinity Capture-MS, Co-fractionation, Two-hybrid, anti bait coimmunoprecipitation, far western blotting, fluorescence microscopy, pull down, two hybrid, two hybrid pooling approach colocalization, physical, physical association 20936779 , 21179510 , 26344197 , 28514442 , (Europe PMC )0.72 BioGRID, IntAct HSPA4 pull down association 28330616 , (Europe PMC )0.35 IntAct HSPH1 pull down association 28330616 , (Europe PMC )0.35 IntAct KIF20A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct NME2 pull down association 28330616 , (Europe PMC )0.35 IntAct NOTCH2NL two hybrid array, two hybrid prey pooling approach, validated two hybrid physical association 25416956 , (Europe PMC )0.56 IntAct NTPCR pull down association 28330616 , (Europe PMC )0.35 IntAct PDCD6 anti tag coimmunoprecipitation, two hybrid physical association 17174262 , (Europe PMC )0.51 IntAct, MINT PSMA3 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct PTK2 anti bait coimmunoprecipitation, fluorescence technology, protein kinase assay, pull down colocalization, direct interaction, phosphorylation reaction, physical association 18835089 , (Europe PMC )0.64 IntAct, MINT RPN1 pull down association 28330616 , (Europe PMC )0.35 IntAct SH3GL2 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, two hybrid physical, physical association 17174262 , (Europe PMC )0.51 BioGRID, IntAct, MINT SHMT2 pull down association 28330616 , (Europe PMC )0.35 IntAct SRC anti bait coimmunoprecipitation, fluorescence technology colocalization, physical association 18835089 , (Europe PMC )0.50 IntAct, MINT STIP1 pull down association 28330616 , (Europe PMC )0.35 IntAct TGOLN2 proximity-dependent biotin identification association 29568061 , (Europe PMC )0.35 IntAct TRIM27 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct TSG101 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, two hybrid physical, physical association 17174262 , 26456826 , (Europe PMC )0.51 BioGRID, IntAct, MINT TUBB4A pull down association 28330616 , (Europe PMC )0.35 IntAct VCAM1 cross-linking study association 22623428 , (Europe PMC )0.35 IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source PDCD6 anti tag coimmunoprecipitation, two hybrid physical association 17174262 , (Europe PMC )0.51 IntAct, MINT PTK2 anti bait coimmunoprecipitation, fluorescence technology, protein kinase assay, pull down colocalization, direct interaction, phosphorylation reaction, physical association 18835089 , (Europe PMC )0.64 IntAct, MINT SH3GL2 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, two hybrid physical, physical association 17174262 , (Europe PMC )0.51 BioGRID, IntAct, MINT SRC anti bait coimmunoprecipitation, fluorescence technology colocalization, physical association 18835089 , (Europe PMC )0.50 IntAct, MINT TSG101 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, two hybrid physical, physical association 17174262 , 26456826 , (Europe PMC )0.51 BioGRID, IntAct, MINT
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ARL1 pull down association 28330616 , (Europe PMC )0.35 IntAct ARMH3 Synthetic Lethality genetic 26472760 , (Europe PMC )NA BioGRID AURKA Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID CAD pull down association 28330616 , (Europe PMC )0.35 IntAct CALR pull down association 28330616 , (Europe PMC )0.35 IntAct CEP55 Two-hybrid physical 25416956 , (Europe PMC )NA BioGRID CEP55 two hybrid array, two hybrid prey pooling approach, validated two hybrid physical association 25416956 , (Europe PMC )0.56 IntAct CHMP4B Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, pull down, two hybrid direct interaction, physical, physical association 17174262 , 18434552 , (Europe PMC )0.66 BioGRID, IntAct, MINT CLINT1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID CLTA Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID CLTB Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID CLTC Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , 27880917 , (Europe PMC )0.35 BioGRID, IntAct DDX24 two hybrid pooling approach physical association 16169070 , (Europe PMC )0.37 IntAct DIAPH1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID EEA1 proximity-dependent biotin identification association 29568061 , (Europe PMC )0.35 IntAct EGFR Affinity Capture-Western physical 23477725 , (Europe PMC )NA BioGRID ESR2 cosedimentation through density gradient association 21182203 , (Europe PMC )0.35 IntAct FGL1 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID GLUD1 pull down association 28330616 , (Europe PMC )0.35 IntAct GRAP2 Affinity Capture-MS, anti bait coimmunoprecipitation, far western blotting, fluorescence microscopy, pull down, two hybrid colocalization, physical, physical association 21179510 , 26186194 , 28514442 , (Europe PMC )0.64 BioGRID, IntAct GRB2 Affinity Capture-MS, Co-fractionation, Two-hybrid, anti bait coimmunoprecipitation, far western blotting, fluorescence microscopy, pull down, two hybrid, two hybrid pooling approach colocalization, physical, physical association 20936779 , 21179510 , 26344197 , 28514442 , (Europe PMC )0.72 BioGRID, IntAct HGS Affinity Capture-Western physical 23477725 , 26456826 , (Europe PMC )NA BioGRID HSPA4 pull down association 28330616 , (Europe PMC )0.35 IntAct HSPH1 pull down association 28330616 , (Europe PMC )0.35 IntAct ITGA4 Affinity Capture-MS physical 22623428 , (Europe PMC )NA BioGRID KIF20A Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct KIF5B Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID KLC1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID KLC2 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID LAGE3 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID LGR4 Affinity Capture-MS physical 24639526 , (Europe PMC )NA BioGRID LRRK2 Two-hybrid physical 19001729 , (Europe PMC )NA BioGRID NME2 pull down association 28330616 , (Europe PMC )0.35 IntAct NOTCH2NL two hybrid array, two hybrid prey pooling approach, validated two hybrid physical association 25416956 , (Europe PMC )0.56 IntAct NOTCH2NLA Two-hybrid physical 25416956 , (Europe PMC )NA BioGRID NTPCR pull down association 28330616 , (Europe PMC )0.35 IntAct NTRK1 Affinity Capture-MS physical 25921289 , (Europe PMC )NA BioGRID P3H1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID PDCD6 anti tag coimmunoprecipitation, two hybrid physical association 17174262 , (Europe PMC )0.51 IntAct, MINT PDCD6IP Affinity Capture-Western physical 17174262 , (Europe PMC )NA BioGRID PPP4R3B Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PRDX5 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID PSMA3 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct PTK2 anti bait coimmunoprecipitation, fluorescence technology, protein kinase assay, pull down colocalization, direct interaction, phosphorylation reaction, physical association 18835089 , (Europe PMC )0.64 IntAct, MINT RPN1 pull down association 28330616 , (Europe PMC )0.35 IntAct SH3GL2 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, two hybrid physical, physical association 17174262 , (Europe PMC )0.51 BioGRID, IntAct, MINT SHMT2 pull down association 28330616 , (Europe PMC )0.35 IntAct SRC anti bait coimmunoprecipitation, fluorescence technology colocalization, physical association 18835089 , (Europe PMC )0.50 IntAct, MINT STAM Affinity Capture-Western physical 26456826 , (Europe PMC )NA BioGRID STAM2 Affinity Capture-Western physical 23477725 , (Europe PMC )NA BioGRID STIP1 pull down association 28330616 , (Europe PMC )0.35 IntAct TGOLN2 proximity-dependent biotin identification association 29568061 , (Europe PMC )0.35 IntAct TRIM27 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.56 BioGRID, IntAct TSG101 Affinity Capture-Western, Two-hybrid, anti tag coimmunoprecipitation, two hybrid physical, physical association 17174262 , 26456826 , (Europe PMC )0.51 BioGRID, IntAct, MINT TUBB4A pull down association 28330616 , (Europe PMC )0.35 IntAct TUBG1 Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID UBAP1 Affinity Capture-Western, Co-crystal Structure, Protein-peptide, Reconstituted Complex, Two-hybrid physical 21757351 , 26456826 , 27839950 , (Europe PMC )NA BioGRID UBC Reconstituted Complex physical 26456826 , (Europe PMC )NA BioGRID USP8 Affinity Capture-Western physical 23477725 , (Europe PMC )NA BioGRID VCAM1 cross-linking study association 22623428 , (Europe PMC )0.35 IntAct VCP Affinity Capture-MS physical 23383273 , (Europe PMC )NA BioGRID VPS26A Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID VWA5A Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID ZFYVE16 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID
Phosphorylating Kinases Phosphoresidues Detection Method PubMed IDs Source
Visualize a network of protein kinases and phosphatases phosphorylating and dephosphorylating this protein respectively
Unknown S1121_AAAADLLsSSPESQH , S1122_AAADLLSsSPESQHG , S1123_AADLLSSsPESQHGG , S1126_LLSSSPEsQHGGTQS , S1133_SQHGGTQsPGGGQPL , T1131_PESQHGGtQSPGGGQ , T587_LIQKDDItASLVTTD , Y679_SQEGRDFyADLESKV , HTP, in vivo 17081983 , 17525332 , 18669648 , 20068231 ,(Europe PMC )HPRD, PhosphoELM ,
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