Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last scientific update:
11 Mar, 2019
last maintenance update:
01 Sep, 2023
Top
KEGG Pathway - TGF-beta signaling pathway - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| MYC | P01106 | PPP2CA, PPP2CB, CTDSP1, |
| RPS6KB1 | P23443 | PPP2CA, PPP2CB, PHLPP1, PHLPP2, |
| MAPK3 | P27361 | CDC25A, DUPD1, PTPN7, DUSP5, DUSP1, DUSP4, DUSP9, DUSP23, PTPRE, PTPRJ, DUSP3, PPP2CA, PTPRR, DUSP14, |
| MAPK1 | P28482 | CDC25A, DUSP22, DUPD1, PTPN7, DUSP5, DUSP1, DUSP4, DUSP6, DUSP9, DUSP7, DUSP2, PPP2CA, PPP2CB, PTPRE, PTPRJ, DUSP3, PTPRR, |
| RBL1 | P28749 | PPP2CA, PPP2CB, |
| BMPR1A | P36894 | CTDNEP1, |
| TGFBR1 | P36897 | PPP1CC, PPP1CA, PPP1CB, |
| SMAD3 | P84022 | MTMR4, PPP2CA, PPP2CB, PPM1A, CTDSP1, CTDSP2, CTDSPL, |
| BMPR2 | Q13873 | PPP2CA, PPP2CB, |
| SMAD2 | Q15796 | PPM1A, CTDSP1, CTDSP2, CTDSPL, |
| SMAD1 | Q15797 | PDP1, PDP2, PPP2CA, PPP2CB, PPM1A, CTDSP1, CTDSP2, CTDSPL, |
| Non-protein substrates in this pathway |
Non-protein substrates involved in this pathway are unknown (yet!)