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CTDNEP1
Localization (UniProt annotation) Endoplasmic reticulum membrane; Single-passmembrane protein Nucleus membrane; Single-pass membrane protein Function (UniProt annotation) Serine/threonine protein phosphatase forming withCNEP1R1 an active phosphatase complex that dephosphorylates andmay activate LPIN1 and LPIN2 LPIN1 and LPIN2 are phosphatidatephosphatases that catalyze the conversion of phosphatidic acid todiacylglycerol and control the metabolism of fatty acids atdifferent levels May indirectly modulate the lipid composition ofnuclear and/or endoplasmic reticulum membranes and be required forproper nuclear membrane morphology and/or dynamics May alsoindirectly regulate the production of lipid droplets andtriacylglycerol May antagonize BMP signaling Catalytic Activity (UniProt annotation) [a protein]-serine/threonine phosphate + H(2)O= [a protein]-serine/threonine + phosphate Protein Sequence MMRTQCLLGLRTFVAFAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPLSPVSRNRLAQVKRKILVLDLDETLIHSHHDGV
LRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQH
CTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQ
HRLW
ELM Motif Motif Instance Description Motif Regex NA NA NA NA
Download FASTA sequences of CTDNEP1-substrates in Humans
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-4419969 Depolymerisation of the Nuclear Lamina. The nuclear envelope breakdown in mitotic prophase involves depolymerisation of lamin filaments, the main constituents of the nuclear lamina. The nuclear lamina is located at the nuclear face of the inner nuclear membrane and plays and important role in the structure and function of the nuclear envelope (reviewed by Burke and Stewart 2012). Depolymerisation of lamin filaments, which consist of lamin homodimers associated through electrostatic interactions in head-to-tail molecular strings, is triggered by phosphorylation of lamins. While CDK1 phosphorylates the N-termini of lamins (Heald and McKeon 1990, Peter et al. 1990, Ward and Kirschner 1990, Mall et al. 2012), PKCs (PRKCA and PRKCB) phosphorylate the C-termini of lamins (Hocevar et al. 1993, Goss et al. 1994, Mall et al. 2012). PKCs are activated by lipid-mediated signaling, where lipins, activated by CTDNEP1:CNEP1R1 serine/threonine protein phosphatase complex, catalyze the formation of DAG (Gorjanacz et al. 2009, Golden et al. 2009, Wu et al. 2011, Han et al. 2012, Mall et al. 2012)
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ABCD3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID ACBD5 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID ALDH3A2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID ATP2A2 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID ATP6AP1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID CCDC107 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CCDC47 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID CDCA3 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID CNEP1R1 Affinity Capture-Western, anti tag coimmunoprecipitation, fluorescence microscopy colocalization, physical, physical association 22134922 , (Europe PMC )0.46 BioGRID, IntAct EMC1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID EMC3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID EVA1C Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID FAM189A2 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID FAM189B Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID GNAI1 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID GRAMD1A Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID HAX1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID HLA-DRB1 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID IL20RB Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID ITPR1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID ITPR2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID ITPR3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID LEMD3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID MOV10 Affinity Capture-RNA physical 22658674 , (Europe PMC )NA BioGRID NDC1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID NXF1 Affinity Capture-RNA physical 22658674 , (Europe PMC )NA BioGRID OCIAD1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID OLFM2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PDGFRB Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PDZD8 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PGRMC2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PLXDC2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID POR Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PTPN1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID SENP2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID SLC17A2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID SMPD4 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID SRPRB Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID SUN1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID SUN2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID SYNE2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID TEX264 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID TGFBR2 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID TLR5 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID TMEM92 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID TRIM13 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID TRIM25 Affinity Capture-RNA physical 29117863 , (Europe PMC )NA BioGRID TUBB6 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID VEZT Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID VPS13A Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID VRK2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ABCD3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID ACBD5 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID ALDH3A2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID ATP2A2 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID ATP6AP1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID CCDC107 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CCDC47 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID CDCA3 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID CNEP1R1 Affinity Capture-Western, anti tag coimmunoprecipitation, fluorescence microscopy colocalization, physical, physical association 22134922 , (Europe PMC )0.46 BioGRID, IntAct EMC1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID EMC3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID EVA1C Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID FAM189A2 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID FAM189B Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID GNAI1 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID GRAMD1A Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID HAX1 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID HLA-DRB1 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID IL20RB Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID ITPR1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID ITPR2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID ITPR3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID LEMD3 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID MOV10 Affinity Capture-RNA physical 22658674 , (Europe PMC )NA BioGRID NDC1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID NXF1 Affinity Capture-RNA physical 22658674 , (Europe PMC )NA BioGRID OCIAD1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID OLFM2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PDGFRB Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID PDZD8 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PGRMC2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PLXDC2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID POR Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID PTPN1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID SENP2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID SLC17A2 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID SMPD4 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID SRPRB Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID SUN1 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID SUN2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID SYNE2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID TEX264 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID TGFBR2 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID TLR5 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID TMEM92 Affinity Capture-MS physical 26186194 , (Europe PMC )NA BioGRID TRIM13 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID TRIM25 Affinity Capture-RNA physical 29117863 , (Europe PMC )NA BioGRID TUBB6 Affinity Capture-MS physical 27880917 , (Europe PMC )NA BioGRID VEZT Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID VPS13A Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID VRK2 Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID