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Localization (UniProt annotation) Cell membrane Cytoplasm,cytoskeleton Apical cell membrane Cell projection, microvillusmembrane Cell projection, microvillus Note=Phosphorylated form isenriched in microvilli-like structures at apical membraneIncreased cell membrane localization of both phosphorylated andnon-phosphorylated forms seen after thrombin treatment (Bysimilarity) Function (UniProt annotation) Probably involved in connections of major cytoskeletalstructures to the plasma membrane May inhibit herpes simplexvirus 1 infection at an early stage Plays a role in regulatingthe proliferation, migration, and adhesion of human lymphoid cellsand participates in immunologic synapse formation(PubMed:27405666) Catalytic Activity (UniProt annotation) N/A Protein Sequence MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRKESPLLFKF
RAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQ
HKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGF
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQMER
AMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAK
EALLQASRDQKKTQEQLALEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENEQ
DEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDESKKTANDMIHAENMRLGRDKYKTLR
QIRQGNTKQRIDEFESM
ELM Motif Motif Instance Description Motif Regex NA NA NA NA
MSN is dephosphorylated by following phosphatases:
Pathway ID Pathway Name Pathway Description (KEGG) hsa04530 Tight junction Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways. hsa04670 Leukocyte transendothelial migration Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. In this process, alphaL /beta2 integrin activates through Vav1, RhoA, which subsequently activates the kinase p160ROCK. ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton. Moreover, Leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. VCAM-1 is involved in the opening of the endothelial passagethrough which leukocytes can extravasate. In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metallopoteinases and loss of VE-cadherin-mediated adhesion. hsa04810 Regulation of actin cytoskeleton hsa05162 Measles Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacterial infections. Several MV proteins have been suggested to disturb host immunity. After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems. Three proteins (P, V, and C) associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis. Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation. hsa05205 Proteoglycans in cancer Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR: 00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-437239 Recycling pathway of L1. L1 functions in many aspects of neuronal development including axon outgrowth and neuronal migration. These functions require coordination between L1 and the actin cytoskeleton. F-actin continuously moves in a retrograde direction from the P-(peripheral) domain of the growth cone towards the growth cone's C-(central) domain. L1, attached to the actin cytoskeleton via membrane cytoskeletal linkers (MCKs) such as ankyrins (Ankyrin-G, -B and -R) and members of the ERMs (ezrin, radixin, and moesin) family, link this retrograde F-actin flow with extracellular immobile ligands.Forward translocation of growth cone requires not only the CAM-actin linkage but also a gradient of cell substrate adhesion (strong adhesion at the front and weak adhesion at the rear) so that the cytoskeletal machinery is able to pull the cell forward as attachments at the rear are released. This asymmetry is achieved in part by internalizing L1 molecules as they are moved to the rear of the growth cone coupled to retrograde F-actin flow and recycling them to the leading edge plasma membrane.L1 internalization is mediated by phosphorylation and dephosphorylation. The L1 cytoplasmic domain (L1CD) carries an endocytic or sorting motif, YRSLE, that is recognized by the clathrin associated adaptor protein-2 (AP-2). AP-2 binds the YRSLE motif only when its tyrosine is not phosphorylated and triggers L1 endocytosis. SRC kinase associated with lipid rafts in the P-domain membrane phosphorylates L1 molecules on tyrosine-1176, stabilizing them in the plasma membrane. L1 endocytosis is triggered by the dephosphorylation of Y1176 within the C domain. Some of these internalized L1 molecules are transported in an anterograde direction along microtubules for reuse in the leading edge R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation. Experiments using human cord blood CD4(+) T cells show 22 protein spots and 20 protein spots, upregulated and downregulated proteins respectively, following Interleukin-12 stimulation (Rosengren et.al, 2005).\n The identified upregulated proteins are: BOLA2, PSME2, MTAP, CA1, GSTA2, RALA, CNN2, CFL1, TCP1, HNRNPDL, MIF, AIP, SOD1, PPIA and PDCD4.And the identified downregulated proteins are:ANXA2, RPLP0, CAPZA1, SOD2, SNRPA1, LMNB1, LCP1, HSPA9, SERPINB2, HNRNPF, TALDO1, PAK2, TCP1, HNRNPA2B1, MSN, PITPNA, ARF1, SOD2, ANXA2, CDC42, RAP1B and GSTO1
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ACAA2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID AHCY Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID AKR1B1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ARHGDIA Co-fractionation, Co-purification physical 15659383 , 26344197 , (Europe PMC )NA BioGRID ASNS Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID ATIC Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID BID Co-purification physical 15659383 , (Europe PMC )NA BioGRID BRCA1 Affinity Capture-MS physical 21282464 , (Europe PMC )NA BioGRID CALR Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CALU Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CAPN2 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID CASP10 Co-purification physical 15659383 , (Europe PMC )NA BioGRID CASP8 Co-purification physical 15659383 , (Europe PMC )NA BioGRID CD2AP Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CD44 Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy colocalization, physical, physical association 23855374 , 9472040 , (Europe PMC )0.46 BioGRID, IntAct CD46 Affinity Capture-Western physical 7884872 , (Europe PMC )NA BioGRID CD81 Affinity Capture-MS, Affinity Capture-Western physical 23463506 , (Europe PMC )NA BioGRID CDC73 Affinity Capture-MS physical 27462432 , (Europe PMC )NA BioGRID CDK11B Two-hybrid, two hybrid physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct CDK2 Affinity Capture-MS, anti bait coimmunoprecipitation physical, physical association 17353931 , 21319273 , (Europe PMC )0.40 BioGRID, IntAct CFTR Affinity Capture-MS physical 26618866 , (Europe PMC )NA BioGRID CTNNB1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID DCPS Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID DHX15 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID DUT Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID EIF5AL1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ELAVL1 Affinity Capture-RNA physical 19322201 , (Europe PMC )NA BioGRID ENO1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ENO2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID EWSR1 Affinity Capture-MS physical 24999758 , (Europe PMC )NA BioGRID EZR Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, anti tag coimmunoprecipitation, proximity-dependent biotin identification, pull down association, physical 15659383 , 26496610 , 29568061 , 7579708 , 8248180 , (Europe PMC )0.60 BioGRID, IntAct FABP5 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID FADD Co-purification physical 15659383 , (Europe PMC )NA BioGRID FAS Co-purification physical 15659383 , (Europe PMC )NA BioGRID FASLG Co-purification physical 15659383 , (Europe PMC )NA BioGRID FAXC Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID FH Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID FKBP2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID FN1 Affinity Capture-MS, cross-linking study association, physical 19738201 , (Europe PMC )0.35 BioGRID, IntAct GDI1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID GINS3 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID GSS Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID GTF3C4 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID H2AFX Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 20000738 , (Europe PMC )0.35 BioGRID, IntAct HADHA Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID HLA-B Affinity Capture-MS, anti bait coimmunoprecipitation physical, physical association 17353931 , (Europe PMC )0.40 BioGRID, IntAct HNRNPA1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HSD17B10 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HSPA4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HSPA4L Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HSPA5 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID HSPB1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HSPE1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HSPH1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ICAM1 Affinity Capture-Western physical 23463506 , (Europe PMC )NA BioGRID ICAM2 Reconstituted Complex physical 9472040 , (Europe PMC )NA BioGRID ICAM3 Affinity Capture-Western, Reconstituted Complex physical 11784723 , 23463506 , 9298994 , (Europe PMC )NA BioGRID IGSF8 Affinity Capture-Western physical 23463506 , (Europe PMC )NA BioGRID IMPA2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ISG15 Affinity Capture-MS, Affinity Capture-Western physical 16009940 , (Europe PMC )NA BioGRID ISYNA1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ITGA4 Affinity Capture-MS physical 22623428 , (Europe PMC )NA BioGRID JUP Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID LCP1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID MAPK10 Affinity Capture-MS, tandem affinity purification association, physical 23602568 , (Europe PMC )0.35 BioGRID, IntAct MAPK8 Co-purification physical 15659383 , (Europe PMC )NA BioGRID MCM2 Affinity Capture-MS physical 25963833 , (Europe PMC )NA BioGRID ME1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID MISP Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MRPL12 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MSN Co-crystal Structure physical 10847681 , (Europe PMC )NA BioGRID MYH9 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct MYO19 Affinity Capture-MS physical 26496610 , (Europe PMC )NA BioGRID NAE1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID NCF1 Affinity Capture-Western, Reconstituted Complex physical 11716484 , (Europe PMC )NA BioGRID NCF4 Affinity Capture-Western, Reconstituted Complex physical 11716484 , (Europe PMC )NA BioGRID NOTCH2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID NSFL1C Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID P4HB Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PAFAH1B1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PAFAH1B2 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PAPSS1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PDHA1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PDIA4 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PFAS Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PGD Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PGK1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PGK2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PLS1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PLS3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PPP1R2 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PTMA Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PTPN1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct RAP1GDS1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID RCN1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID RHOA Co-purification physical 15659383 , (Europe PMC )NA BioGRID S100A16 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SELL Reconstituted Complex physical 11706008 , (Europe PMC )NA BioGRID SELPLG Reconstituted Complex physical 12115638 , (Europe PMC )NA BioGRID SIRT7 Affinity Capture-MS physical 22586326 , (Europe PMC )NA BioGRID SLC9A3R1 Reconstituted Complex, affinity chromatography technology, fluorescence microscopy, pull down, x-ray crystallography colocalization, direct interaction, physical, physical association 15020681 , 9430655 , (Europe PMC )0.68 BioGRID, IntAct SMURF1 Biochemical Activity physical 20804422 , (Europe PMC )NA BioGRID SPN Affinity Capture-Western, Reconstituted Complex physical 9472040 , 9616160 , (Europe PMC )NA BioGRID SPTAN1 Affinity Capture-Western physical 11441066 , (Europe PMC )NA BioGRID SRCAP Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID STIP1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID STK24 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID TAGLN2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TATDN1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID TERF1 Two-hybrid, bimolecular fluorescence complementation, pull down physical, physical association 21044950 , (Europe PMC )0.51 BioGRID, IntAct TKT Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TNFRSF10B Co-purification physical 15659383 , (Europe PMC )NA BioGRID TNFRSF1A Co-purification physical 15659383 , (Europe PMC )NA BioGRID TRIM15 PCA physical 25450970 , (Europe PMC )NA BioGRID TSC1 Two-hybrid physical 12226091 , (Europe PMC )NA BioGRID TSPAN33 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID TUBB3 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID U2AF2 Affinity Capture-MS physical 26641092 , (Europe PMC )NA BioGRID UCHL3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID VCAM1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, cross-linking study association, physical 12082081 , 19738201 , 22623428 , 23463506 , (Europe PMC )0.53 BioGRID, IntAct VCL Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID VPS11 Reconstituted Complex physical 21148287 , (Europe PMC )NA BioGRID WDR1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source CDK11B Two-hybrid, two hybrid physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct CDK2 Affinity Capture-MS, anti bait coimmunoprecipitation physical, physical association 17353931 , 21319273 , (Europe PMC )0.40 BioGRID, IntAct EBI-1059081 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct ELF3 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct EZR Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, anti tag coimmunoprecipitation, proximity-dependent biotin identification, pull down association, physical 15659383 , 26496610 , 29568061 , 7579708 , 8248180 , (Europe PMC )0.60 BioGRID, IntAct FN1 Affinity Capture-MS, cross-linking study association, physical 19738201 , (Europe PMC )0.35 BioGRID, IntAct H2AFX Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 20000738 , (Europe PMC )0.35 BioGRID, IntAct HLA-B Affinity Capture-MS, anti bait coimmunoprecipitation physical, physical association 17353931 , (Europe PMC )0.40 BioGRID, IntAct HLA-C anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct IKBKE anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct LRRK2 protein kinase assay phosphorylation reaction 20642453 , 22363216 , 22952686 , 23241358 , 24351927 , 24695735 , 24904275 , 25009464 , 26824392 , 27357661 , (Europe PMC )0.95 IntAct MAPK10 Affinity Capture-MS, tandem affinity purification association, physical 23602568 , (Europe PMC )0.35 BioGRID, IntAct MYBPC2 two hybrid fragment pooling approach physical association 23414517 , (Europe PMC )0.37 IntAct MYH9 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct MYO19 anti tag coimmunoprecipitation association 26496610 , (Europe PMC )0.35 IntAct PLEK anti bait coimmunoprecipitation, pull down association 19722192 , (Europe PMC )0.46 IntAct PRKAB1 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct PTPN1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct SLC9A3R1 Reconstituted Complex, affinity chromatography technology, fluorescence microscopy, pull down, x-ray crystallography colocalization, direct interaction, physical, physical association 15020681 , 9430655 , (Europe PMC )0.68 BioGRID, IntAct SNCG anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct SYK pull down association 12387735 , (Europe PMC )0.35 IntAct, MINT TERF1 Two-hybrid, bimolecular fluorescence complementation, pull down physical, physical association 21044950 , (Europe PMC )0.51 BioGRID, IntAct TRAF6 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct VCAM1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, cross-linking study association, physical 12082081 , 19738201 , 22623428 , 23463506 , (Europe PMC )0.53 BioGRID, IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source ACAA2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID AHCY Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID AKR1B1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ARHGDIA Co-fractionation, Co-purification physical 15659383 , 26344197 , (Europe PMC )NA BioGRID ASNS Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID ATIC Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID BID Co-purification physical 15659383 , (Europe PMC )NA BioGRID BRCA1 Affinity Capture-MS physical 21282464 , (Europe PMC )NA BioGRID CALR Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CALU Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CAPN2 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID CASP10 Co-purification physical 15659383 , (Europe PMC )NA BioGRID CASP8 Co-purification physical 15659383 , (Europe PMC )NA BioGRID CD2AP Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID CD44 Reconstituted Complex, anti bait coimmunoprecipitation, confocal microscopy colocalization, physical, physical association 23855374 , 9472040 , (Europe PMC )0.46 BioGRID, IntAct CD46 Affinity Capture-Western physical 7884872 , (Europe PMC )NA BioGRID CD81 Affinity Capture-MS, Affinity Capture-Western physical 23463506 , (Europe PMC )NA BioGRID CDC73 Affinity Capture-MS physical 27462432 , (Europe PMC )NA BioGRID CDK11B Two-hybrid, two hybrid physical, physical association 21988832 , (Europe PMC )0.37 BioGRID, IntAct CDK2 Affinity Capture-MS, anti bait coimmunoprecipitation physical, physical association 17353931 , 21319273 , (Europe PMC )0.40 BioGRID, IntAct CFTR Affinity Capture-MS physical 26618866 , (Europe PMC )NA BioGRID CTNNB1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID DCPS Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID DHX15 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID DUT Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID EBI-1059081 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct EIF5AL1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ELAVL1 Affinity Capture-RNA physical 19322201 , (Europe PMC )NA BioGRID ELF3 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct ENO1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ENO2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID EWSR1 Affinity Capture-MS physical 24999758 , (Europe PMC )NA BioGRID EZR Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, anti tag coimmunoprecipitation, proximity-dependent biotin identification, pull down association, physical 15659383 , 26496610 , 29568061 , 7579708 , 8248180 , (Europe PMC )0.60 BioGRID, IntAct FABP5 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID FADD Co-purification physical 15659383 , (Europe PMC )NA BioGRID FAS Co-purification physical 15659383 , (Europe PMC )NA BioGRID FASLG Co-purification physical 15659383 , (Europe PMC )NA BioGRID FAXC Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID FH Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID FKBP2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID FN1 Affinity Capture-MS, cross-linking study association, physical 19738201 , (Europe PMC )0.35 BioGRID, IntAct GDI1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID GINS3 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID GSS Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID GTF3C4 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID H2AFX Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 20000738 , (Europe PMC )0.35 BioGRID, IntAct HADHA Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID HLA-B Affinity Capture-MS, anti bait coimmunoprecipitation physical, physical association 17353931 , (Europe PMC )0.40 BioGRID, IntAct HLA-C anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct HNRNPA1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HSD17B10 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HSPA4 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HSPA4L Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HSPA5 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID HSPB1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HSPE1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID HSPH1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ICAM1 Affinity Capture-Western physical 23463506 , (Europe PMC )NA BioGRID ICAM2 Reconstituted Complex physical 9472040 , (Europe PMC )NA BioGRID ICAM3 Affinity Capture-Western, Reconstituted Complex physical 11784723 , 23463506 , 9298994 , (Europe PMC )NA BioGRID IGSF8 Affinity Capture-Western physical 23463506 , (Europe PMC )NA BioGRID IKBKE anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct IMPA2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ISG15 Affinity Capture-MS, Affinity Capture-Western physical 16009940 , (Europe PMC )NA BioGRID ISYNA1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID ITGA4 Affinity Capture-MS physical 22623428 , (Europe PMC )NA BioGRID JUP Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID LCP1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID LRRK2 protein kinase assay phosphorylation reaction 20642453 , 22363216 , 22952686 , 23241358 , 24351927 , 24695735 , 24904275 , 25009464 , 26824392 , 27357661 , (Europe PMC )0.95 IntAct MAPK10 Affinity Capture-MS, tandem affinity purification association, physical 23602568 , (Europe PMC )0.35 BioGRID, IntAct MAPK8 Co-purification physical 15659383 , (Europe PMC )NA BioGRID MCM2 Affinity Capture-MS physical 25963833 , (Europe PMC )NA BioGRID ME1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID MISP Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MRPL12 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID MSN Co-crystal Structure physical 10847681 , (Europe PMC )NA BioGRID MYBPC2 two hybrid fragment pooling approach physical association 23414517 , (Europe PMC )0.37 IntAct MYH9 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct MYO19 Affinity Capture-MS physical 26496610 , (Europe PMC )NA BioGRID MYO19 anti tag coimmunoprecipitation association 26496610 , (Europe PMC )0.35 IntAct NAE1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID NCF1 Affinity Capture-Western, Reconstituted Complex physical 11716484 , (Europe PMC )NA BioGRID NCF4 Affinity Capture-Western, Reconstituted Complex physical 11716484 , (Europe PMC )NA BioGRID NOTCH2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID NSFL1C Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID P4HB Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PAFAH1B1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PAFAH1B2 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PAPSS1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PDHA1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PDIA4 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PFAS Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PGD Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PGK1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PGK2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PLEK anti bait coimmunoprecipitation, pull down association 19722192 , (Europe PMC )0.46 IntAct PLS1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PLS3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID PPP1R2 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PRKAB1 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct PTMA Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID PTPN1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct RAP1GDS1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID RCN1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID RHOA Co-purification physical 15659383 , (Europe PMC )NA BioGRID S100A16 Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID SELL Reconstituted Complex physical 11706008 , (Europe PMC )NA BioGRID SELPLG Reconstituted Complex physical 12115638 , (Europe PMC )NA BioGRID SIRT7 Affinity Capture-MS physical 22586326 , (Europe PMC )NA BioGRID SLC9A3R1 Reconstituted Complex, affinity chromatography technology, fluorescence microscopy, pull down, x-ray crystallography colocalization, direct interaction, physical, physical association 15020681 , 9430655 , (Europe PMC )0.68 BioGRID, IntAct SMURF1 Biochemical Activity physical 20804422 , (Europe PMC )NA BioGRID SNCG anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct SPN Affinity Capture-Western, Reconstituted Complex physical 9472040 , 9616160 , (Europe PMC )NA BioGRID SPTAN1 Affinity Capture-Western physical 11441066 , (Europe PMC )NA BioGRID SRCAP Co-fractionation physical 22939629 , (Europe PMC )NA BioGRID STIP1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID STK24 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID SYK pull down association 12387735 , (Europe PMC )0.35 IntAct, MINT TAGLN2 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TATDN1 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID TERF1 Two-hybrid, bimolecular fluorescence complementation, pull down physical, physical association 21044950 , (Europe PMC )0.51 BioGRID, IntAct TKT Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID TNFRSF10B Co-purification physical 15659383 , (Europe PMC )NA BioGRID TNFRSF1A Co-purification physical 15659383 , (Europe PMC )NA BioGRID TRAF6 anti bait coimmunoprecipitation physical association 17353931 , (Europe PMC )0.40 IntAct TRIM15 PCA physical 25450970 , (Europe PMC )NA BioGRID TSC1 Two-hybrid physical 12226091 , (Europe PMC )NA BioGRID TSPAN33 Affinity Capture-MS physical 26186194 , 28514442 , (Europe PMC )NA BioGRID TUBB3 Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID U2AF2 Affinity Capture-MS physical 26641092 , (Europe PMC )NA BioGRID UCHL3 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID VCAM1 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, cross-linking study association, physical 12082081 , 19738201 , 22623428 , 23463506 , (Europe PMC )0.53 BioGRID, IntAct VCL Co-fractionation physical 22863883 , (Europe PMC )NA BioGRID VPS11 Reconstituted Complex physical 21148287 , (Europe PMC )NA BioGRID WDR1 Co-fractionation physical 26344197 , (Europe PMC )NA BioGRID
Phosphorylating Kinases Phosphoresidues Detection Method PubMed IDs Source
Visualize a network of protein kinases and phosphatases phosphorylating and dephosphorylating this protein respectively
GRK2 T558_LGRDKYKtLRQIRQG , NA NA PhosphoSitePlus , LOK T558_LGRDKYKtLRQIRQG , LTP 19255442 ,(Europe PMC )PhosphoELM , LRRK2 T558_LGRDKYKtLRQIRQG , LTP 17447891 ,(Europe PMC )PhosphoELM , PhosphoSitePlus , MAP3K8 T558_LGRDKYKtLRQIRQG , NA NA PhosphoSitePlus , MAP4K4 T558_LGRDKYKtLRQIRQG , NA NA PhosphoSitePlus , PKA_group T558_LGRDKYKtLRQIRQG , LTP 15634677 ,(Europe PMC )PhosphoELM , PRKACA T558_LGRDKYKtLRQIRQG , NA NA PhosphoSitePlus , PRKCQ T558_LGRDKYKtLRQIRQG , in vitro 9516463 , 9856983 ,(Europe PMC )HPRD, PhosphoSitePlus , ROCK1 T558_LGRDKYKtLRQIRQG , in vitro 9516463 , 9856983 ,(Europe PMC )HPRD, PhosphoSitePlus , ROCK_group T558_LGRDKYKtLRQIRQG , LTP 19255442 , 9516463 ,(Europe PMC )PhosphoELM , STK10 T558_LGRDKYKtLRQIRQG , NA NA PhosphoSitePlus , Unknown S407_KEALLQAsRDQKKTQ , S468_AELKTAMsTPHVAEP , S527_KHLKALTsELANARD , S576_QRIDEFEsM , T465_KTRAELKtAMSTPHV , T469_ELKTAMStPHVAEPA , T558_LGRDKYKtLRQIRQG , LTP, in vivo 18212344 , 18669648 , 19651622 , 20068231 , 20166139 , 9856983 ,(Europe PMC )HPRD, PhosphoELM ,
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